Advanced Science最新文献_第9页

Ubc9-Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9-p16 Axis. ubc9介导的RPL3的SUMOylation，通过抑制DHX9-p16轴抑制肝细胞衰老的未被认识的机制。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-10-20 DOI: 10.1002/advs.202510240

Hao Xie, Zhichao Gao, Xin Liu, Shiyi Zhang, Yuhan Wang, Jia Gao, Ping Qi, Lu Zhang, Jiawei Zhao, Tian Xiong, Teng Huang, Jia Song, Qilin Yu, Shu Zhang, Yanjun Liu, Ping Yang, Maryam S Al-Motawa, Quan Gong, Junfeng Dong, Hao Yin, Fei Sun, Shiwei Liu, Cong-Yi Wang

{"title":"Ubc9-Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9-p16 Axis.","authors":"Hao Xie, Zhichao Gao, Xin Liu, Shiyi Zhang, Yuhan Wang, Jia Gao, Ping Qi, Lu Zhang, Jiawei Zhao, Tian Xiong, Teng Huang, Jia Song, Qilin Yu, Shu Zhang, Yanjun Liu, Ping Yang, Maryam S Al-Motawa, Quan Gong, Junfeng Dong, Hao Yin, Fei Sun, Shiwei Liu, Cong-Yi Wang","doi":"10.1002/advs.202510240","DOIUrl":"https://doi.org/10.1002/advs.202510240","url":null,"abstract":"Although Ubc9-mediated SUMOylation are recognized to regulate the multiple aspects of hepatic biological processes, its impact on hepatic senescence and metabolic dysfunction-associated steatotic liver disease (MASLD), however, is yet to be fully addressed. Herein noted an age-dependent decrease of hepatic Ubc9 expression is first noted along with an escalated decrease of protein SUMOylation, which is coupled with enhanced senescent marker expressions both in humans and mice. Interestingly, Ubc9 is dispensable for liver development at the embryonic stage. However, Ubc9 deficiency in hepatocytes rendered mice with an exacerbated hepatic aging phenotype and more susceptible to fatty liver disease and steatohepatitis following the challenge of a methionine- and choline-deficient (MCD)-diet. Ii is further demonstrated that nuclear ribosomal protein L3 (RPL3) interacts with DExD/H-box (DDX/DHX) helicases (DHX9), which then recruits RNA polymerase II to the p16 promoter to transcribe its expression, thereby exacerbating the hepatocyte aging process. However, Ubc9-mediated SUMOylation prevents RPL3 nuclear translocation, by which it represses the expression of senescent markers such as p16 to attenuate the hepatic aging process. Together, the study highlights that Ubc9-mediated SUMOylation of RPL3 could be an unappreciated mechanism against hepatic aging in clinical settings.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e10240"},"PeriodicalIF":14.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145327896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constructing Dual-Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration. 构建双原子铁─铁位点纳米酶通过减轻氧化应激和软骨退变靶向治疗骨关节炎。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-10-20 DOI: 10.1002/advs.202508073

Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu

{"title":"Constructing Dual-Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration.","authors":"Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu","doi":"10.1002/advs.202508073","DOIUrl":"https://doi.org/10.1002/advs.202508073","url":null,"abstract":"Osteoarthritis progression is driven by excessive reactive oxygen species (ROS), which causes significant secondary damage to chondrocytes and articular cartilage. Herein, the concept of holding desired dual-site nanozymes is proposed through developing Fe─Fe dimers on nitrogen-doped porous carbon (Fe2-NCs) to eliminate excessive ROS through the co-adsorption mechanism of superoxide radical. The Fe2-NCs present an enhanced ROS performance, effectively mimicking key antioxidant enzymes. Density functional theory calculations indicate that the synergistic effects of the Fe─Fe dimer can modulate oxygen adsorption configurations and accelerating O─O bond-cleavage. In vitro and in vivo results show that Fe2-NCs effectively mitigate ROS, protecting chondrocytes from oxidative stress-induced apoptosis. The mitochondrial function can be strengthened over Fe2-NCs by inhibiting NOX4 expression, restoring ATP levels, and normalizing COXIV expression. Additionally, Fe2-NCs significantly downregulate the pro-inflammatory mediator COX-2, inhibit MMP-13-mediated cartilage degradation, and slow down the type II collagen (COL2) breakdown through the inhibition of NF-κB signaling pathway.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e08073"},"PeriodicalIF":14.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145327914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

METTL10-Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression. mettl10介导的PIAS3甲基化将嘌呤代谢与胃癌进展联系起来。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-10-20 DOI: 10.1002/advs.202507054

Jinshui Tan, Huiwen Zhou, Jingsong Ma, Chensong Zhang, Yuhua Tan, Baoding Zhang, Jiabao Zhao, Ao Cheng, Chengyu Yang, Meijuan Xu, Shengyi Zhou, Yubo Xiong, Zeyang Lin, Guangchao Pan, Wenjie Ye, Mengya Zhong, Yang Yang, Yifan Zhuang, Shao-Wei Li, Xianming Deng, Xuehui Hong

{"title":"METTL10-Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression.","authors":"Jinshui Tan, Huiwen Zhou, Jingsong Ma, Chensong Zhang, Yuhua Tan, Baoding Zhang, Jiabao Zhao, Ao Cheng, Chengyu Yang, Meijuan Xu, Shengyi Zhou, Yubo Xiong, Zeyang Lin, Guangchao Pan, Wenjie Ye, Mengya Zhong, Yang Yang, Yifan Zhuang, Shao-Wei Li, Xianming Deng, Xuehui Hong","doi":"10.1002/advs.202507054","DOIUrl":"https://doi.org/10.1002/advs.202507054","url":null,"abstract":"Metabolic dysregulation plays a significant role in the development of gastric cancer (GC). However, the mechanisms that control this change and its impact on GC progression remain poorly understood. In this study, it is demonstrated that methyltransferase-like 10 (METTL10) is a key regulator of gastric tumor formation by enhancing purine metabolism in GC cells. It is discovered that METTL10 methylates the protein inhibitor of activated STAT3 (PIAS3) at the lysine 442 (K442) residue, which interferes with the interaction of PIAS3 with microphthalmia-associated transcription factor (MITF). As a result, the sumoylation and ubiquitination of MITF by PIAS3 are reduced, leading to MITF stabilization and activation of purine metabolism. Importantly, both the accumulation of MITF and the methylation of K442 in PIAS3 are required for the oncogenic effects of METTL10, and both factors are closely linked to poor clinical outcomes in GC. Furthermore, this study identified a compound, LZQ-02-023-01, which effectively induces the METTL10-mediated ubiquitination and degradation of MITF, thereby reducing the oncogenic activity of METTL10. The findings suggest that METTL10 plays an important role in reprogramming purine metabolism, which promotes GC, highlighting it as a potential therapeutic target for GC treatment.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e07054"},"PeriodicalIF":14.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145327927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Directed Self-Assembly of Magnetic Bioceramic Deep Inside Dentinal Tubules May Alleviate Dental Hypersensitivity (Adv. Sci. 39/2025) 磁性生物陶瓷在牙本质小管深处的定向自组装可能减轻牙齿过敏（Sci. 39/2025）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.71952

Shanmukh Peddi, Prajwal Hegde, Prannay Reddy, Anaxee Barman, Arnab Barik, Debayan Dasgupta, Ambarish Ghosh

引用次数: 0

Piezoelectric-Metal Phononic Crystal Enabling GHz Tunable Ultrahigh Q Quasi-BIC Mode. 实现GHz可调谐超高Q准bic模式的压电-金属声子晶体。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.202513664

Xuankai Xu, Jiawei Li, Ruoyu Wang, Ruihong Xiong, Yiwei Wang, Xiaoqin Shen, Tao Wu

{"title":"Piezoelectric-Metal Phononic Crystal Enabling GHz Tunable Ultrahigh Q Quasi-BIC Mode.","authors":"Xuankai Xu, Jiawei Li, Ruoyu Wang, Ruihong Xiong, Yiwei Wang, Xiaoqin Shen, Tao Wu","doi":"10.1002/advs.202513664","DOIUrl":"https://doi.org/10.1002/advs.202513664","url":null,"abstract":"The integration of GHz-frequency, high-quality factor (Q), and electrically tunable acoustic resonators holds significant potential for advancing applications in quantum information technologies, microwave photonics, and reconfigurable RF systems. However, simultaneously achieving these three characteristics within a single, scalable platform remains a fundamental challenge. Here, the experimental demonstration of a GHz quasi-BIC resonator in a piezoelectric thin-film shear horizontal (SH) wave system, achieved through a structurally simple piezoelectric-metal phononic crystal (PnC) architecture on a LiNbO3 thin film, is reported. This approach enables leaky Fabry-Perot coupling mode and localized trapping quasi-BIC mode. Without the need for deep etching or intricate patterning, a high room-temperature quality factor of ≈6.5 × 104 at ≈1 GHz in ambient air is achieved, corresponding to an f × Q product of ≈6.4 × 1013 Hz at quasi-BIC mode. Furthermore, efficient electrical tunability is demonstrated via low-voltage (0.6 V) electrothermal modulation of the PnC structure, enabling a reversible transition between trapped and transmission states and yielding a high-contrast amplitude modulation of 47.75 dB. This work opens new directions for scalable on-chip phononic circuits in quantum acoustics, reconfigurable RF systems, and signal processing applications.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e13664"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface Adhesion Engineering for Armored Metasurfaces and Beyond. 装甲超表面及其他表面的表面粘附工程。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.202514000

Lianwei Chen, Chengjun Zhang, Ahai Zhou, Qingsong Wang, Yao Fang, Jiangning Zhou, Xiong Li, Yinghui Guo, Yizhe Zhao, Mingbo Pu, Xiangang Luo

引用次数: 0

Symmetry Breaking in Chemical Systems: Engineering Complexity Through Self-Organization and Marangoni Flows. 化学系统中的对称性破缺：自组织和马兰戈尼流的工程复杂性。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.202515672

Sangram Gore, Binaya R Paudyal, Duarte Rocha, Mohamed Ali, Nader Masmoudi, Albert J Bae, Christian Diddens, Detlef Lohse, Oliver Steinbock, Azam Gholami

{"title":"Symmetry Breaking in Chemical Systems: Engineering Complexity Through Self-Organization and Marangoni Flows.","authors":"Sangram Gore, Binaya R Paudyal, Duarte Rocha, Mohamed Ali, Nader Masmoudi, Albert J Bae, Christian Diddens, Detlef Lohse, Oliver Steinbock, Azam Gholami","doi":"10.1002/advs.202515672","DOIUrl":"https://doi.org/10.1002/advs.202515672","url":null,"abstract":"Far from equilibrium, chemical and biological systems can form complex patterns and waves through reaction-diffusion coupling. Fluid motion often interferes with these self-organized concentration patterns. This study examines the influence of Marangoni-driven flows inside a thin layer of fluid ascending the outer surfaces of hydrophilic obstacles on the spatio-temporal dynamics of chemical waves in the modified Belousov-Zhabotinsky reaction. These observations reveal that circular waves originate nearly simultaneously at the obstacles and propagate outward. In a covered setup, where evaporation is minimal, the wavefronts maintain their circular shape. However, in an uncovered setup with significant evaporation and resulting Marangoni flows, the interplay between surface tension-driven Marangoni flows and gravity destabilizes the wavefronts, creating distinctive flower-like patterns around the obstacles. Experiments further show that the number of petals increases linearly with obstacle diameter, though a minimum diameter is required for these instabilities to appear. Our complementary numerical analysis indicates that solutal Marangoni forces dominate thermal ones in this system. These findings demonstrate the potential to \"engineer\" specific wave patterns, offering a method to control and direct reaction dynamics. This capability is especially important for developing microfluidic devices requiring precise control over chemical wave propagation.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e15672"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: (Adv. Sci. 39/2025) 发布信息：（ad . Sci. 39/2025）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.71953

引用次数: 0

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury. 药理小胶质细胞抑制重塑瘢痕微环境以支持脊髓损伤后网状脊髓回路重建。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.202503966

Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang

{"title":"Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury.","authors":"Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang","doi":"10.1002/advs.202503966","DOIUrl":"https://doi.org/10.1002/advs.202503966","url":null,"abstract":"Due to an inhibitory scar microenvironment that prevents neural circuit reconstruction, spinal cord injury (SCI) often leads to persistent neurological dysfunction. Although neonatal murine models demonstrate that microglial inhibition enables scar remodeling to support neuroregeneration and functional recovery, effective pharmacological suppression of microglial activation in adult SCI remain elusive. Here, this work demonstrates that early β2-adrenergic receptor agonist treatment drives microglial transition to a homeostatic phenotype within the post-SCI scar. This intervention reduces inhibitory extracellular matrix deposition and transforms the inhibitory microenvironments into permissive substrates for axonal regrowth. Anatomical analyses reveal regeneration of the reticulospinal tract, which establishes synaptic connectivity with thoracolumbar circuits to mediate motor recovery in a complete SCI. These findings elucidate the therapeutic potential and neural circuit mechanisms underlying pharmacological microglial modulation for SCI repair, establishing a glial-neural circuit reparative paradigm.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e03966"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BRIGHT Enables High-SNR Live-Cell Imaging of Non-Repetitive Sequences via Bivalent Fluorescent Nanobody-Mediated Cascade-Dependent Illumination. BRIGHT通过二价荧光纳米体介导的级联依赖照明实现非重复序列的高信噪比活细胞成像。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2025-10-17 DOI: 10.1002/advs.202513014

Lei Feng, Tao Huang, Yanxi Han, Meng Tian, Duo Wang, Zilong Mei, Yu Ma, Yingshuo Ma, Jinming Li, Rui Zhang

{"title":"BRIGHT Enables High-SNR Live-Cell Imaging of Non-Repetitive Sequences via Bivalent Fluorescent Nanobody-Mediated Cascade-Dependent Illumination.","authors":"Lei Feng, Tao Huang, Yanxi Han, Meng Tian, Duo Wang, Zilong Mei, Yu Ma, Yingshuo Ma, Jinming Li, Rui Zhang","doi":"10.1002/advs.202513014","DOIUrl":"https://doi.org/10.1002/advs.202513014","url":null,"abstract":"Genomic loci and genome-independent DNA exhibit heterogeneous dynamics related to physiological function. Live-cell imaging of non-repetitive sequences is essential but limited by low signal-to-noise ratio (SNR), restricting accurate identification and dynamic tracking. Here, the development of a BRIGHT (bivalent near-infrared nanobody-mediated cascade illumination of genomic loci for high-SNR tracking) system for non-repetitive sequence live imaging is reported. BRIGHT employs dCas9-n×ALFA to target genomic loci and realizes high SNR by triggering cascade-dependent illumination via bivalent binding and antigen-dependent illumination of a bivalent near-infrared fluorescent nanobody targeting ALFA tags (Bi-NIR-FbALFA). BRIGHT achieves ≈6.26-fold and ≈6.76-fold higher SNR than SunTag and PP7-PCP in telomere labeling, and enables non-repetitive DNA imaging with SNR up to 284.84. Furthermore, BRIGHT tracks chromatin dynamics comparably to previous tools, links dynamics and nuclear positioning to transcriptional activity, and detects the distribution and dynamic heterogeneity of extrachromosomal circular DNA (eccDNA). Overall, BRIGHT dramatically improves the SNR of non-repetitive sequence imaging and offers an innovative tool for studying genomic dynamics and gene regulation.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e13014"},"PeriodicalIF":14.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0