Advanced Science最新文献_第9页

Superior-Selective and Complete Recycling of Trace Precious Metals From Wastewater by Magnetic Trilayer Carbon-Aerogels. 磁性三层碳气凝胶超选择性完全回收废水中痕量贵金属。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-28 DOI: 10.1002/advs.202500858

Jianzheng Yang, Yan Zhou, Shang Du, Bing Wu, Jianying Zhang, Shanjun Song, Tao Zhou, Jinming Zhang

{"title":"Superior-Selective and Complete Recycling of Trace Precious Metals From Wastewater by Magnetic Trilayer Carbon-Aerogels.","authors":"Jianzheng Yang, Yan Zhou, Shang Du, Bing Wu, Jianying Zhang, Shanjun Song, Tao Zhou, Jinming Zhang","doi":"10.1002/advs.202500858","DOIUrl":"https://doi.org/10.1002/advs.202500858","url":null,"abstract":"It is a considerable challenge to selectively recycle precious metals from industrial wastewater and natural waters. Herein, carbon aerogels embedded with magnetic Fe@FeS@C nanoparticles (CFeS aerogels) were constructed from natural carrageenan. The unique redox potential of FeS, coupled with the barrier effect and the electron conduction property of the carbon layer, made the Fe@FeS@C nanoparticles exhibited the ultra-high ion selectivity. The resultant CFeS aerogels can selectively adsorb and reduce trace Au(III), Ag(I), and Pd(II) ions at ppb level in an aqueous solution with 29 coexisting cations. Even if the concentration of competing metal ions is 100-fold higher than those of the precious metal ions, the selectivity for Au(III), Ag(I), and Pd(II) ions remained above 99.2%. Moreover, the 3D carbon network immobilizing the Fe@FeS@C nanoparticles prevented the aggregation and detachment of the recycled precious metals, thereby enhancing the adsorption rate and capacity. CFeS aerogels rapidly achieved adsorption equilibrium for Au(III), Ag(I), and Pd(II) ions in 5-10 min, and have the saturated adsorption capacities of 321.2 mg·g-1, 150.6 mg·g-1, and 70.1 mg·g-1, respectively. Such aerogels with ultra-high selectivity, high efficiency, and easy separation provided a practical strategy for the enrichment and recovery of the precious metals.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e00858"},"PeriodicalIF":14.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Human Engineered Heart Tissue-Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin. 人类工程化心脏组织源性脂毒性糖尿病心肌病模型揭示了恩格列净的早期益处。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-28 DOI: 10.1002/advs.202503173

Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang

{"title":"A Human Engineered Heart Tissue-Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin.","authors":"Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang","doi":"10.1002/advs.202503173","DOIUrl":"https://doi.org/10.1002/advs.202503173","url":null,"abstract":"Diabetic cardiomyopathy (DbCM) is increasingly prevalent, but intervention targets remain unclear due to the lack of appropriate models and the complexity of risk factors. Here, this work establishes an in vitro assessment system for DbCM function using cardiomyocytes derived from human pluripotent stem cells and engineered heart tissue. This work finds high-fat status in complex diabetes risk factors majorly contributes most to cardiomyocyte death and contractile dysfunction. Notably, PA induced early electrophysiological abnormalities, and lately is associated with cardiac fibrosis, mitochondrial fission, and systolic and diastolic dysfunction at tissue level. Using this in vitro assessment system, this work finds that empagliflozin (EMPA), a first-line glucose-lowering drug, effectively alleviated early PA-induced cardiomyocyte injury. Treatment with EMPA enhanced abnormal diastolic and electrophysiological functions in the PA-hEHT model and significantly reduced endoplasmic reticulum stress, and apoptosis. Furthermore, these promising results are confirmed in a type 2 diabetes mellitus mouse model, reinforcing the potential of EMPA as a therapeutic option to alleviate cardiomyocyte injury under diabetic conditions. These findings suggest that this work has developed an engineered model of diabetic cardiomyopathy that mimics the various stages of lipotoxic myocardial injury and support the use of EMPA as a potential therapeutic option for diabetic or lipotoxic cardiomyopathy.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e03173"},"PeriodicalIF":14.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomal CMTM4 Induces Immunosuppressive Macrophages to Promote Ovarian Cancer Progression and Attenuate Anti-PD-1 Immunotherapy. 外泌体CMTM4诱导免疫抑制巨噬细胞促进卵巢癌进展和减弱抗pd -1免疫治疗

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-28 DOI: 10.1002/advs.202504436

Bo Yin, Jianyi Ding, Jie Liu, Haoran Hu, Yashi Zhu, Meiqin Yang, Huijuan Zhou, Baoyou Huang, Tiefeng Huang, Mengjie Li, Yinyan He, Ang Li, Lingfei Han

{"title":"Exosomal CMTM4 Induces Immunosuppressive Macrophages to Promote Ovarian Cancer Progression and Attenuate Anti-PD-1 Immunotherapy.","authors":"Bo Yin, Jianyi Ding, Jie Liu, Haoran Hu, Yashi Zhu, Meiqin Yang, Huijuan Zhou, Baoyou Huang, Tiefeng Huang, Mengjie Li, Yinyan He, Ang Li, Lingfei Han","doi":"10.1002/advs.202504436","DOIUrl":"https://doi.org/10.1002/advs.202504436","url":null,"abstract":"Exosomes shape the tumor microenvironment (TME) by modulating tumor-associated macrophages (TAMs) and promoting ovarian cancer (OC) progression. This study reveals that exosomal CKLF Like MARVEL Transmembrane Domain Containing 4 (CMTM4) enhances OC malignancy and orchestrates immune evasion. Excessive macrophage infiltration in the TME, particularly in the presence of CMTM4, is strongly associated with poor prognosis. Within the TME, exosomal CMTM4 is actively internalized by macrophages, promoting M2 polarization and subsequently initiating immunosuppressive signaling. Exosomal CMTM4 activates the NF-κB pathway in TAMs, suppressing immune function through enhanced secretion of cytokines, including TGF-β1 and CXCL12, while simultaneously upregulating intercellular adhesion molecule-1 (ICAM1) expression to further promote M2 polarization and facilitate cancer metastasis. Depletion of CMTM4 increases sensitivity to anti-PD-1 therapy by reversing immunosuppression. Notably, eltrombopag is identified as a CMTM4 inhibitor that attenuates OC progression in vivo and modulates the tumor immune microenvironment, synergizing with PD-1 blockade immunotherapy to enhance therapeutic efficacy. The exosomal CMTM4-ICAM1-CD206 axis exacerbates disease risk in patients with OC. Collectively, the study highlights the critical role of tumor-derived exosomal CMTM4 in immune suppression, emphasizing its potential as both a prognostic biomarker and a therapeutic target in OC immunotherapy.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e04436"},"PeriodicalIF":14.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Sequential Targeting Chondroitin Sulfate-Bilirubin Nanomedicine Attenuates Osteoarthritis via Reprogramming Lipid Metabolism in M1 Macrophages". 对“顺序靶向硫酸软骨素-胆红素纳米药物通过重编程M1巨噬细胞脂质代谢减轻骨关节炎”的修正。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-26 DOI: 10.1002/advs.202507227

引用次数: 0

Intracellular Formation of Synthetic Peptide Nanostructures Causes Mitochondrial Disruption and Cell Death in Tumor Spheroids. 细胞内合成肽纳米结构的形成导致肿瘤球体的线粒体破坏和细胞死亡。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-26 DOI: 10.1002/advs.202412606

Sarah Chagri, Konrad Maxeiner, Maria J S A Silva, Lisa Förch, Julian Link, Patrick Roth, Raphael Meyer, Jana Fetzer, Anke Kaltbeitzel, Ingo Lieberwirth, Katharina Landfester, Manfred Wagner, David Y W Ng, Tanja Weil

{"title":"Intracellular Formation of Synthetic Peptide Nanostructures Causes Mitochondrial Disruption and Cell Death in Tumor Spheroids.","authors":"Sarah Chagri, Konrad Maxeiner, Maria J S A Silva, Lisa Förch, Julian Link, Patrick Roth, Raphael Meyer, Jana Fetzer, Anke Kaltbeitzel, Ingo Lieberwirth, Katharina Landfester, Manfred Wagner, David Y W Ng, Tanja Weil","doi":"10.1002/advs.202412606","DOIUrl":"https://doi.org/10.1002/advs.202412606","url":null,"abstract":"Supramolecular assemblies found in nature demonstrate the concept of creating functionality through structure formation. In recent years, these complex natural architectures have inspired the development of materials for the formation of synthetic nanostructures within living cells. These intracellular assemblies have the potential to modulate cellular processes, yet their specific effects on cellular metabolism and 3D cell networks, such as tumor spheroids, still remain underexplored. Herein, the study correlates the glutathione-induced formation of synthetic nanostructures inside MDA-MB-231 triple-negative breast cancer cells to the metabolic disruption and mitochondrial degradation observed in 2D cell culture, as well as to cell death and size decrease in a 3D tumor spheroid model. In 2D cell culture, material-cell interactions are examined through live-cell imaging and by quantifying changes in mitochondrial respiration. By studying the interplay between glutathione-responsive cytosolic peptide assembly and the implications on the integrity of the mitochondrial network, as well as on 3D cell networks, the work advances the understanding of how synthetic intracellular nanofibers impact vital functions of living cells.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2412606"},"PeriodicalIF":14.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

deepTFBS: Improving within- and Cross-Species Prediction of Transcription Factor Binding Using Deep Multi-Task and Transfer Learning. deepTFBS：利用深度多任务和迁移学习改进转录因子结合的物种内和物种间预测。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-24 DOI: 10.1002/advs.202503135

Jingjing Zhai, Yuzhou Zhang, Chujun Zhang, Xiaotong Yin, Minggui Song, Chenglong Tang, Pengjun Ding, Zenglin Li, Chuang Ma

{"title":"deepTFBS: Improving within- and Cross-Species Prediction of Transcription Factor Binding Using Deep Multi-Task and Transfer Learning.","authors":"Jingjing Zhai, Yuzhou Zhang, Chujun Zhang, Xiaotong Yin, Minggui Song, Chenglong Tang, Pengjun Ding, Zenglin Li, Chuang Ma","doi":"10.1002/advs.202503135","DOIUrl":"https://doi.org/10.1002/advs.202503135","url":null,"abstract":"The precise prediction of transcription factor binding sites (TFBSs) is crucial in understanding gene regulation. In this study, deepTFBS, a comprehensive deep learning (DL) framework that builds a robust DNA language model of TF binding grammar for accurately predicting TFBSs within and across plant species is presented. Taking advantages of multi-task DL and transfer learning, deepTFBS is capable of leveraging the knowledge learned from large-scale TF binding profiles to enhance the prediction of TFBSs under small-sample training and cross-species prediction tasks. When tested using available information on 359 Arabidopsis TFs, deepTFBS outperformed previously described prediction strategies, including position weight matrix, deepSEA and DanQ, with a 244.49%, 49.15%, and 23.32% improvement of the area under the precision-recall curve (PRAUC), respectively. Further cross-species prediction of TFBS in wheat showed that deepTFBS yielded a significant PRAUC improvement of 30.6% over these three baseline models. deepTFBS can also utilize information from gene conservation and binding motifs, enabling efficient TFBS prediction in species where experimental data availability is limited. A case study, focusing on the WUSCHEL (WUS) transcription factor, illustrated the potential use of deepTFBS in cross-species applications, in our example between Arabidopsis and wheat. deepTFBS is publically available at https://github.com/cma2015/deepTFBS.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e03135"},"PeriodicalIF":14.3,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine. 神经类器官的生成及其在疾病建模和再生医学中的应用。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-24 DOI: 10.1002/advs.202501198

Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu

{"title":"Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine.","authors":"Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu","doi":"10.1002/advs.202501198","DOIUrl":"https://doi.org/10.1002/advs.202501198","url":null,"abstract":"The complexity and precision of the human nervous system have posed significant challenges for researchers seeking suitable models to elucidate refractory neural disorders. Traditional approaches, including monolayer cell cultures and animal models, often fail to replicate the intricacies of human neural tissue. The advent of organoid technology derived from stem cells has addressed many of these limitations, providing highly representative platforms for studying the structure and function of the human embryonic brain and spinal cord. Researchers have induced neural organoids with regional characteristics by mimicking morphogen gradients in neural development. Recent advancements have demonstrated the utility of neural organoids in disease modeling, offering insights into the pathophysiology of various neural disorders, as well as in the field of neural regeneration. Developmental defects in neural organoids due to the lack of microglia or vascular systems are addressed. In addition to induction methods, microfluidics is used to simulate the dynamic physiological environment; bio-manufacturing technologies are employed to regulate physical signaling and shape the structure of complex organs. These technologies further expand the construction strategies and application scope of neural organoids. With the emergence of new material paradigms and advances in AI, new possibilities in the realm of neural organoids are witnessed.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e01198"},"PeriodicalIF":14.3,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterojunction Derived Efficient Charge Separation for High Sensitivity Self-Powered Flexible Photodetectors toward Real-Time Heart Rate Monitoring. 用于实时心率监测的高灵敏度自供电柔性光电探测器的异质结衍生高效电荷分离。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-24 DOI: 10.1002/advs.202505945

Nan Ding, Ge Zhu, Xiaotao Zhang, Wen Xu, Hailong Liu, Yanan Ji, Yuanzheng Chen, Bin Dong

{"title":"Heterojunction Derived Efficient Charge Separation for High Sensitivity Self-Powered Flexible Photodetectors toward Real-Time Heart Rate Monitoring.","authors":"Nan Ding, Ge Zhu, Xiaotao Zhang, Wen Xu, Hailong Liu, Yanan Ji, Yuanzheng Chen, Bin Dong","doi":"10.1002/advs.202505945","DOIUrl":"https://doi.org/10.1002/advs.202505945","url":null,"abstract":"Real-time and accurate heart rate monitoring is crucial in the field of disease prevention and early diagnosis. Compared with the conventional rigid heart rate sensors, wearable flexible devices have unique advantages, such as convenient, high comfortable to the skin, and low data extraction errors. Currently, the available flexible electronic devices encounter with large power consumption, low detectivity, and slow response time, restricting their further commercial applications. Herein, flexible self-powered photodetectors (PDs) are developed by the synergistic strategy of engineering CsPbI3:Ho3+@SnS quantum dots (QDs) p-n heterojunctions and doping SnS QDs into spiro-OMeTAD hole transport layer (HTL). The designing CsPbI3:Ho3+@SnS QDs p-n heterojunctions as the photosensitive layer to effectively enhance the built-in field, reduce defect density, and boost the charge separation efficiency. Meanwhile, the high hole mobility and suitable energy band structure of p-type SnS QDs are doped into spiro-OMeTAD HTL, which can improve the hole extraction, and balance electron and hole mobilities. Such flexible self-powered PDs exhibit excellent sensitivity and stability with high responsivity (0.58 A W-1) and detectivity (1.13×1013 Jones), and fast response time (98.8 µs). The flexible self-powered PDs are further integrated with the light-emitting diodes (LEDs) as a photoplethysmography (PPG) system, realizing real-time and accurate heart rate monitoring.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2505945"},"PeriodicalIF":14.3,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Omics and -Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset. 脓毒症早期发病的多组学和器官能量代谢适应研究。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-24 DOI: 10.1002/advs.202504418

Lin-Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou

{"title":"Multi-Omics and -Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset.","authors":"Lin-Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou","doi":"10.1002/advs.202504418","DOIUrl":"https://doi.org/10.1002/advs.202504418","url":null,"abstract":"Systemic metabolic dysregulation in sepsis critically impacts patient survival. To better understand its onset, untargeted serum metabolomics and lipidomics are analyzed from 152 presymptomatic patients undergoing major elective surgery, and identified key metabolites, including serine and aminoadipic acid, that differentiate postoperative uncomplicated infection from sepsis. Using single-nucleus RNA sequencing data from an in vivo mouse model of sepsis, tissue-independent down-regulation and tissue-specific differences of serine and energy-related genes including key module roles for the mitochondria-linked genes, Cox4i1, Cox8a, and Ndufa4 are identified. Finally, serine-dependent metabolic shifts, especially in the liver, are revealed by using 12C/13C murine data with labeled serine, and link altered activity of the serine hydroxymethyltransferase (SHMT) cycle with perturbed purine metabolism during sepsis. This study demonstrates the close interrelationship between early metabolite changes and mitochondrial dysfunction in sepsis, improves the understanding of the underlying pathophysiology, and highlights metabolic targets to prospectively treat presymptomatic, but at-risk, patients.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e04418"},"PeriodicalIF":14.3,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2D Conductive MOFs Intercalated in MXene Interlayer for Fast and Trace Detection of Triethylamine at Room Temperature. MXene夹层中嵌入二维导电mof用于室温下快速痕量检测三乙胺。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-24 DOI: 10.1002/advs.202500786

Hao Zhang, Wei Cao, Jingfeng Wang, Lei Guo, Pu-Hong Wang, Zhi-Jun Ding, Lingmin Yu

{"title":"2D Conductive MOFs Intercalated in MXene Interlayer for Fast and Trace Detection of Triethylamine at Room Temperature.","authors":"Hao Zhang, Wei Cao, Jingfeng Wang, Lei Guo, Pu-Hong Wang, Zhi-Jun Ding, Lingmin Yu","doi":"10.1002/advs.202500786","DOIUrl":"https://doi.org/10.1002/advs.202500786","url":null,"abstract":"Metal-organic frameworks (MOFs) are newly developed materials for gas sensing applications currently. However, the prolonged response time limits their future applications because of their poor electrical conductivity. In this context, alternating stacked MXene@Cu-HHTP heterostructures characterized by a sandwich-type architecture comprised of Cu-HHTP (copper-catecholate frameworks), 2D conductive MOFs, and layered MXene achieve high-performance triethylamine (TEA) sensing. The unique interlayer pore architecture within the MXene@Cu-HHTP composites facilitates efficient mass transfer of gas molecules while retaining the large surface area and porosity characteristics of the MOFs, leading to rapid TEA response. MXene@Cu-HHTP composites respond to 50 ppm TEA in only 4 s and low detection limit (1 ppm). Demonstrated higher sensitivity compared to the original Cu-HHTP sensor (≈21 times at 200 ppm TEA). At room temperature and atmospheric conditions, the value of moisture resistance of MXene@Cu-HHTP composites can reach 80% through continuous real-time dynamic testing.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2500786"},"PeriodicalIF":14.3,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0