Advanced SciencePub Date : 2025-07-21DOI: 10.1002/advs.202501694
Ying-Ying Jiao, Tian Tian, Zhu Zhu, Lei Cao, Yang Liu, Rui-An Wang, Zhi-Yong Zhou, Cong Wang, Ke-Zhong Zhang, Xiao Lu, Wen-Wei Yun, Ying-Mei Lu, Gang Hu, Ren-Hong Du, Ming Lu
{"title":"Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α-Synuclein Endocytosis in Parkinson's Disease.","authors":"Ying-Ying Jiao, Tian Tian, Zhu Zhu, Lei Cao, Yang Liu, Rui-An Wang, Zhi-Yong Zhou, Cong Wang, Ke-Zhong Zhang, Xiao Lu, Wen-Wei Yun, Ying-Mei Lu, Gang Hu, Ren-Hong Du, Ming Lu","doi":"10.1002/advs.202501694","DOIUrl":"https://doi.org/10.1002/advs.202501694","url":null,"abstract":"<p><p>The spread or transmission of pathologic α-synuclein (α-Syn) is emerging as potentially important driver of Parkinson's disease (PD) pathogenesis. Emerging evidence suggests that astrocytes play an important role in uptake/clearance of extracellular α-Syn. However, underlying mechanisms and molecular entities responsible for uptake/clearance of extracellular α-Syn by astrocytes are not known. Here, it is shown that lipocalin-2 (LCN2) is upregulated in astrocytes of MPTP-treated mice by RNA-Seq analysis and positively correlates with pathologic α-Syn level in α-Syn PFF model. Strikingly, deletion of astrocytic LCN2 significantly prevents the pathologic α-Syn accumulation and neurodegeneration. Moreover, 24p3R as a crucial receptor of α-Syn uptake by astrocytes is identified, as well as an important mediator of α-Syn spread in the brain. 24p3R specifically binds to α-Syn and then mediates α-Syn uptake. LCN2 prevents astrocytic uptake of α-Syn by impeding the binding of 24p3R and α-Syn. The identification of LCN2/24p3R as a key regulator of α-Syn by astrocytes provides a new target for the treatment of PD and related α-synucleinopathies.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e01694"},"PeriodicalIF":14.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lutetium-Based Nanoprobes for Radiosensitization with Immune Microenvironment Remodeling and NIR-II Fluorescence Imaging-Guided Surgery in Colorectal Cancer.","authors":"Yongying Dang, Xianzhi Liu, Zifan Zheng, Ao Wang, Ying Huang, Zhong Luo, Haina Tian, Siyaqi Li, Qiang Luo, Peiyuan Wang, Weiling He","doi":"10.1002/advs.202510136","DOIUrl":"https://doi.org/10.1002/advs.202510136","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is among the top five leading cancers worldwide. Preoperative concurrent chemoradiotherapy is recommended for locally advanced CRC. Radiotherapy (RT), a traditional cancer treatment, not only controls local tumor growth but also potentially induces immunogenic cell death, initiating systemic immune responses. Given the poor radiosensitivity of CRC, improving RT sensitization is a critical unmet need. Despite advances in intraoperative imaging, achieving complete resection of colorectal tumors with clear margins in real time remains a significant clinical challenge. This study introduces RVLu@ICG, a novel multifunctional fluorescent nanoprobe emitting in the second near-infrared (NIR-II) range. It's demonstrated that RVLu@ICG has tumor-specific targeting due to modification with cyclic arginine-glycine-aspartic acid (c(RGDfK)) pentapeptide and induces augmented reactive oxygen species (ROS) production under ionizing radiation exposure. This synergistic mechanism not only potentiates radiosensitization efficacy but also facilitates radiation-induced remodeling of the tumor immune microenvironment. Additionally, NIR-II fluorescence image guidance facilitates precise surgical navigation in microtumor models, intramuscular tumor invasion models, and peritoneal metastasis models. Notably, the nanoprobe demonstrates excellent biocompatibility both in vitro and in vivo. Thus, RVLu@ICG establishes a robust precision therapy platform for the treatment of CRC.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e10136"},"PeriodicalIF":14.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-07-21DOI: 10.1002/advs.202506251
Florin Adler, Sebastián Pinto-Bautista, Christoph Lorenz, Lars Hinrichs, Marcel Weil, Birgit Esser
{"title":"Synthesis of Poly(1,4-anthraquinone) Using Catalytic Amounts of Nickel.","authors":"Florin Adler, Sebastián Pinto-Bautista, Christoph Lorenz, Lars Hinrichs, Marcel Weil, Birgit Esser","doi":"10.1002/advs.202506251","DOIUrl":"https://doi.org/10.1002/advs.202506251","url":null,"abstract":"<p><p>Multivalent metal batteries are attractive options to diversify energy storage options offering higher sustainability, but the high charge density of multivalent ions poses challenges to electrode materials. Organic electrode materials are currently the best-performing candidates, and among them, poly(1,4-anthraquinone) (P14AQ) shows excellent electrochemical properties. This holds in particular for magnesium-ion batteries, where the polymer displays reversible insertion of Mg<sup>2+</sup> ions with high cycling stability. The conventional synthesis of P14AQ, however, employs stoichiometric amounts of bis(cycloocta-1,5-diene)nickel(0) (Ni(COD)<sub>2</sub>), which is an air- and light-sensitive and expensive chemical, and therefore lacks sustainability. Herein a synthetic route to P14AQ is presented that uses only catalytic amounts of dibromobis(triphenylphosphine)nickel(II) (NiBr<sub>2</sub>(PPh<sub>3</sub>)<sub>2</sub>). This route - in addition to being more cost-efficient and less toxic - results in higher yields and polymer molecular weights. A life-cycle assessment (LCA) comparing the new and conventional polymerization methods shows that regarding the environmental impact categories climate change, human toxicity, and cumulative energy demand, the new method brings significant improvement.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e06251"},"PeriodicalIF":14.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MXene/Carboxymethyl Chitosan Moisture Responsive Soft Actuator with Diode-Like Actuation for Versatile Applications Driven by Human Metabolism.","authors":"Liangliang Xu, Yangyang Ling, Ziqing Li, Xinyu Xu, Xiaoxia Li, Longfei Chang, Qingyu Peng, Ying Hu","doi":"10.1002/advs.202507845","DOIUrl":"https://doi.org/10.1002/advs.202507845","url":null,"abstract":"<p><p>Moisture responsive soft actuators are receiving increasing attention due to their unique potential in reducing external energy dependence and carbon footprint. For the conventional moisture responsive soft actuators, their bending deformation under moisture stimulation is usually bidirectional, and the orientation of the bending axis is random. Achieving a moisture responsive monolithic actuator with controllable unidirectional deformation remains a challenge. Here, a Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene/carboxymethyl chitosan composite film actuator with thickness gradient along length direction is fabricated via a vacuum-assisted \"tilt-filtration\" approach. The actuator exhibits a \"diode-like\" controllable unidirectional deformation behavior under moisture gradient, and its deformation direction is strictly correlated to its thickness gradient direction and moisture source direction. Based on this highly correlated actuation behavior with internal structural asymmetry, a self-sustained oscillator under a constant moisture gradient is achieved. Besides, various multifunctional applications based on this actuator driven by human metabolism are also demonstrated, including non-contact switch with unidirectional conductivity, intelligent keyboard for non-contact character input, biomimetic crawling robot, wearable intelligent thermal management clothing, and a self-powered respiratory sensor. This work paves the way for the realization of moisture responsive soft actuators with unidirectional controllable deformation, and further promotes the development of sustainable intelligent materials in soft robotics and electronics.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e07845"},"PeriodicalIF":14.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sleep Deprivation Activates a Conserved Lactate-H3K18la-RORα Axis Driving Neutrophilic Inflammation Across Species.","authors":"Ren Zhou, Keyun Li, Xiezong Hu, Shuhao Fan, Yuxuan Gao, Xiaoshu Xue, Yu Bu, Haoyi Zhang, Yili Wang, Chunjiao Wei, Shangrong Zhang, Zhongwen Xie, Chao Liu, Peng Chen, Zongjun Yin, Dalong Ren","doi":"10.1002/advs.202504028","DOIUrl":"https://doi.org/10.1002/advs.202504028","url":null,"abstract":"<p><p>Sleep deprivation critically disrupts physiological homeostasis, impairing development, metabolic balance, and immune regulation, with excessive neutrophil activation being a hallmark consequence. However, the molecular mechanisms underlying sleep deprivation-induced neutrophilic inflammation remain elusive. Here, it is shown that acute sleep deprivation in mice triggers neutrophil hyperactivation, resulting in aberrant peripheral accumulation and a systemic cytokine storm. Mechanistically, this pathology is driven by metabolic dysregulation, specifically, increased glycolytic flux, which elevates tissue lactate levels and enhances histone H3K18 lactylation. Through H3K18 lactylation-specific CUT&Tag profiling, pronounced lactylation enrichment is identified at the promoter of the Rorα gene, directly activating its transcription. Genetic ablation of Rorα or pharmacological inhibition of glycolysis attenuate neutrophil recruitment and mitigated inflammation in sleep-deprived zebrafish. Strikingly, this metabolic‒epigenetic axis is evolutionarily conserved, as demonstrated by the recapitulation of key findings in diurnal zebrafish and pigs. The study reveals a lactate-H3K18 lactylation-Rorα signaling cascade that links sleep deprivation to immune dysregulation, suggesting actionable targets for combating sleep-related inflammatory disorders.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e04028"},"PeriodicalIF":14.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-07-21DOI: 10.1002/advs.202500950
Dijun Ouyang, Tong Xiang, Yuanyuan Chen, Mengjia Song, Jingjing Zhao, Hao Chen, Si Li, Lifeng Zhang, Chi Xu, Yan Ren, Yong Tao, Qijing Wang, Jia He, Yongqiang Li, Sisi Xie, Yuanyuan Liu, Yan Wang, Xinyi Yang, Jinqi You, Songzuo Xie, Yingzi Li, Desheng Weng, Qiuzhong Pan, Qi Yang, Jianchuan Xia
{"title":"The CXCL10-CXCR3 Axis Induces Tumor-Associated Neutrophils to Interfere with CTLs-Mediated Antitumor Activity in EBV-Associated Epithelial Cancers.","authors":"Dijun Ouyang, Tong Xiang, Yuanyuan Chen, Mengjia Song, Jingjing Zhao, Hao Chen, Si Li, Lifeng Zhang, Chi Xu, Yan Ren, Yong Tao, Qijing Wang, Jia He, Yongqiang Li, Sisi Xie, Yuanyuan Liu, Yan Wang, Xinyi Yang, Jinqi You, Songzuo Xie, Yingzi Li, Desheng Weng, Qiuzhong Pan, Qi Yang, Jianchuan Xia","doi":"10.1002/advs.202500950","DOIUrl":"https://doi.org/10.1002/advs.202500950","url":null,"abstract":"<p><p>Although Epstein-Barr virus (EBV)-associated epithelial cancers are categorized as immunologically \"hot\" tumors, they have unsatisfactory responses to immunotherapy. Increasing evidence has shown that therapeutic failure is due to an immunosuppressive tumor microenvironment established by EBV. In this study, a negative correlation is found between the infiltration of neutrophils and that of cytotoxic T lymphocytes (CTLs) containing granzyme B in EBV-associated epithelial cancers. The CXCL10-CXCR3 axis in EBV-associated epithelial cancer cells controls the extrusion of neutrophil extracellular traps (NETs), which interferes with the antitumor activity of EBV antigen-specific T cells in vitro and in vivo. NETs are positively correlated with the number of dysfunctional CTLs in EBV-associated epithelial cancers, and are confirmed to be an independent prognostic factor for patients with EBV-associated epithelial cancers. In conclusion, these findings reveal a novel mechanism of immunosuppression of tumor-associated neutrophils (TANs) in EBV-associated epithelial cancers. Targeting NETs formation in TANs may be a potential strategy for improving the efficacy of immunotherapy against EBV-associated epithelial cancers.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e00950"},"PeriodicalIF":14.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-07-21DOI: 10.1002/advs.202505206
Michael J Rupar, Hannah M Hanson, Brianna L Botlick, Narasimhan Sriram, Stephanie Rogers, Justin Zuniga, Zhanhe Liu, Steven J Trimmer, Joseph M Ciurca, Christopher J Long, Christopher W McAleer, Stephan Schmidt, Paola Favuzza, Philip Lowe, Nathalie Gobeau, James J Hickman
{"title":"Translation of a Human-Based Malaria-on-a-Chip Phenotypic Disease Model for In Vivo Applications.","authors":"Michael J Rupar, Hannah M Hanson, Brianna L Botlick, Narasimhan Sriram, Stephanie Rogers, Justin Zuniga, Zhanhe Liu, Steven J Trimmer, Joseph M Ciurca, Christopher J Long, Christopher W McAleer, Stephan Schmidt, Paola Favuzza, Philip Lowe, Nathalie Gobeau, James J Hickman","doi":"10.1002/advs.202505206","DOIUrl":"https://doi.org/10.1002/advs.202505206","url":null,"abstract":"<p><p>In 2023 malaria claimed ≈600000 lives, with 90% of those deaths attributed to the Plasmodium falciparum parasite. This resurgence in mortality emphasizes the necessity of adopting alternative models to accelerate therapeutic development. The Malaria-on-a-Chip model used here incorporated human liver, spleen, and endothelium with P. falciparum-infected blood, and was maintained for 7 days using serum-free medium. This model sustained all stages of the intraerythrocytic life cycle and allowed for organ-organ interaction, providing advantageous preclinical insight into malaria pathophysiology. Chloroquine, lumefantrine, or artesunate were delivered as monotherapies to 3D7 or W2-infected systems. Dose-dependent parasite clearance was observed in both strains for all compounds. Recrudescence occurred in the 3D7-infected model following treatment with chloroquine or lumefantrine, but not artesunate. In W2-infected systems, chloroquine and lumefantrine treatment resulted in parasitemia stabilization by day 7, while artesunate further reduced parasitemia. Population dynamics modeling of pharmacokinetic and pharmacodynamic (PK/PD) outcomes were utilized to predict human in vivo parameters for efficacy and off-target toxicity using in vitro results.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e05206"},"PeriodicalIF":14.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-07-21DOI: 10.1002/advs.202500942
Tian-Xiang Zhang, Xiaoxiao Yang, Xue Gao, Xiaoshan Du, Xuegan Lian, Naiyuan Shao, Ye Liu, Zhenning Huang, Dongmei Jia, Alexander Y L Lau, Zhiguo Li, Zaal Kokaia, Fu-Dong Shi, Chao Zhang
{"title":"Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder.","authors":"Tian-Xiang Zhang, Xiaoxiao Yang, Xue Gao, Xiaoshan Du, Xuegan Lian, Naiyuan Shao, Ye Liu, Zhenning Huang, Dongmei Jia, Alexander Y L Lau, Zhiguo Li, Zaal Kokaia, Fu-Dong Shi, Chao Zhang","doi":"10.1002/advs.202500942","DOIUrl":"https://doi.org/10.1002/advs.202500942","url":null,"abstract":"<p><p>Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease characterized by anti-aquaporin 4 (AQP4) antibody-mediated astrocyte damage and subsequent demyelination. Prior attempts to treat NMOSD with interferon-beta (IFN-β), a disease-modifying therapy for multiple sclerosis, resulted in worsening of disease activity, with an unknown mechanism. Here, robust activation of the cGAS-STING-IFN-I signaling pathway is identified in myeloid cells in both the periphery and central nervous system. The abnormal IFN-I response gives rise to an increase in the number of AQP4 antigen-specific autoreactive T cells. Sting deficiency can significantly blunt the activation of AQP4-specific T cells, as well as the IFN-I activity in microglia, and attenuate astrocyte damage. Consequently, the clinical manifestation of NMOSD is ameliorated in a passive transfer mouse model of NMOSD. Further, treatment with STING inhibitor H151 alleviates the severity of NMOSD mouse models. These findings uncover the cGAS-STING-IFN-I pathway in promoting autoreactive T cells and establish a foundation for inhibiting this pathway as a new therapeutic revenue for NMOSD.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e00942"},"PeriodicalIF":14.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-07-21DOI: 10.1002/advs.202505214
Minjeong Cho, Su Min Kim, Jiyeon Lee, Oh Chan Kwon, Wonjin Woo, Eunji Lee, Hyo Jin Park, Yeongun Lee, So Hee Dho, Tae-Kyung Kim, Min-Chan Park, Richard A Flavell, Lark Kyun Kim
{"title":"Targeting eRNA-Producing Super-Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient-Derived Immune Cells.","authors":"Minjeong Cho, Su Min Kim, Jiyeon Lee, Oh Chan Kwon, Wonjin Woo, Eunji Lee, Hyo Jin Park, Yeongun Lee, So Hee Dho, Tae-Kyung Kim, Min-Chan Park, Richard A Flavell, Lark Kyun Kim","doi":"10.1002/advs.202505214","DOIUrl":"https://doi.org/10.1002/advs.202505214","url":null,"abstract":"<p><p>Chronic inflammatory diseases are driven by immune cell dysregulation and overproduction of pro-inflammatory molecules, such as tumor necrosis factor alpha (TNFα). Super-enhancers (SEs) and their enhancer RNAs (eRNAs) are critical gene expression regulators and offer therapeutic potential beyond protein-targeting approaches. This work hypothesizes that targeting eRNAs could reduce chronic inflammation by modulating TNFα expression. This work generates TNF-9 knockout (KO) mice by deleting a Tnfα-regulating enhancer region. These mice exhibit significantly reduced Tnfα levels, improved disease outcomes, and diminished immune cell activation in models of rheumatoid arthritis (RA), psoriasis, and lipopolysaccharide (LPS)-induced sepsis. Integrative epigenomic and transcriptomic analysis identify additional LPS-responsive, eRNA-producing enhancers as therapeutic targets. Antisense oligonucleotide (ASO)-mediated knockdown of TNF-9 eRNA in mouse macrophages demonstrate decreased Tnfα expression and alleviated RA symptoms. Furthermore, ASO-mediated inhibition of the eRNA of the human homolog of TNF-9 similarly reduce TNFα levels. These findings support eRNA-targeted interventions as potential treatment for chronic inflammatory diseases.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e05214"},"PeriodicalIF":14.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Liquid Metal-Embedded Sheath-Core Fiber with Internal Helical Structure for Strain-Insensitive Electronics.","authors":"Mengying Luo, Wanru Wei, Qiye Guo, Weibing Zhong, Kangyu Jia, Kangqi Chang, Ying Lu, Mufang Li, Dong Wang","doi":"10.1002/advs.202509547","DOIUrl":"https://doi.org/10.1002/advs.202509547","url":null,"abstract":"<p><p>Stable conductivity is crucial for flexible wearable devices, ensuring reliable signal transmission, sensing accuracy, optimal display performance, and overall device reliability. However, simultaneously achieving high elasticity, superior conductivity, and robust stability remains a formidable challenge. This study presents a novel core-sheath fiber with an internal helical structure as the core layer and an intrinsic elastic material as the sheath layer, which combines the intrinsic elastic material and extensile spiral structure to realize high stretchability, ultra-conductivity, and strain-insensitivity. The hollow fiber with helical channel is fabricated via coaxial wet-spinning technology by adjusting the flow velocity, with an elongation at break of ≈1440%. Subsequent infusion of liquid metal into the channel endows the fiber with outstanding conductivity, reaching 1.94 × 10<sup>5</sup> S m<sup>-1</sup>. Benefiting from the helical structure, the obtained fibers exhibit outstanding strain-insensitivity with a high Q value of 62.5 (resistance variation <1.6%) under 100% strain and show only 30% resistance change even at 600% elongation. The fibers exhibit superior stability against bending, twisting, and compressive deformations. The PU sheath provides excellent waterproof properties, enabling reliable operation in aqueous environments. Moreover, these fibers can be woven into fabrics, exhibiting outstanding performance in joule heaters, near-field communication, and wireless charging applications.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e09547"},"PeriodicalIF":14.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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