Advanced Science最新文献_第8页

Cyclo-N₉ ^-: a Novel 5/6 Fused Polynitrogen Anion for High Energy Density Materials.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202414394

Xiaofeng Yuan, Ze Xu, Haolin Gu, Tongwei Zhang, Yuangang Xu, Ming Lu

{"title":"Cyclo-N9 -: a Novel 5/6 Fused Polynitrogen Anion for High Energy Density Materials.","authors":"Xiaofeng Yuan, Ze Xu, Haolin Gu, Tongwei Zhang, Yuangang Xu, Ming Lu","doi":"10.1002/advs.202414394","DOIUrl":"https://doi.org/10.1002/advs.202414394","url":null,"abstract":"After cyclo-pentazolate anion, a 5/6 fused structure of N9 - is constructed, and four novel nitrogen-rich ionic compounds are assembled on its basis. The results of the quantum calculations revealed an uneven distribution of electrons on cyclo-N9 -, with significant charge density near the N5/N9 atoms and an ADCH charge of -0.425. The relative strength of chemical bonds is assessed through bond order analysis, which is further supplemented by transition state theory and ab initio molecular dynamics, ultimately leading to the identification of the decomposition pathways of cyclo-N9 -. The aromaticity of cyclo-N9 - and its individual sub-rings is cleverly validated through a combination of NICS_ZZ and ICSS methods. Among the eight systems, cyclo-N9 - forms hydrogen bonds with other cations, and IGMH analysis revealed significant LP-π and π-π stacking interactions between [N7H4 +] and cyclo-N9 -, both of which enhance system stability. The theoretical energy densities in all systems are at the forefront in the currently emerging nitrogen-rich compounds. Attributed to its extraordinarily high enthalpy of formation, the detonation performance of [N7H4 +] [N9 -] is particularly excellent. However, [NH3OH+] [N9 -] exhibits better stability and most exciting performance, making it a highly promising candidate with application potential.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2414394"},"PeriodicalIF":14.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Conductivity, Self-Healing, and Adhesive Ionic Hydrogels for Health Monitoring and Human-Machine Interactions Under Extreme Cold Conditions.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202412726

Fei Han, Shumeng Chen, Fei Wang, Mei Liu, Jiahui Li, Hao Liu, Yanshen Yang, Haoqing Zhang, Dong Liu, Rongyan He, Wentao Cao, Xiaochuan Qin, Feng Xu

{"title":"High-Conductivity, Self-Healing, and Adhesive Ionic Hydrogels for Health Monitoring and Human-Machine Interactions Under Extreme Cold Conditions.","authors":"Fei Han, Shumeng Chen, Fei Wang, Mei Liu, Jiahui Li, Hao Liu, Yanshen Yang, Haoqing Zhang, Dong Liu, Rongyan He, Wentao Cao, Xiaochuan Qin, Feng Xu","doi":"10.1002/advs.202412726","DOIUrl":"https://doi.org/10.1002/advs.202412726","url":null,"abstract":"Ionic conductive hydrogels (ICHs) are emerging as key materials for advanced human-machine interactions and health monitoring systems due to their unique combination of flexibility, biocompatibility, and electrical conductivity. However, a major challenge remains in developing ICHs that simultaneously exhibit high ionic conductivity, self-healing, and strong adhesion, particularly under extreme low-temperature conditions. In this study, a novel ICH composed of sulfobetaine methacrylate, methacrylic acid, TEMPO-oxidized cellulose nanofibers, sodium alginate, and lithium chloride is presented. The hydrogel is designed with a hydrogen-bonded and chemically crosslinked network, achieving excellent conductivity (0.49 ± 0.05 S m-1), adhesion (36.73 ± 2.28 kPa), and self-healing capacity even at -80 °C. Furthermore, the ICHs maintain functionality for over 45 days, showcasing outstanding anti-freezing properties. This material demonstrates significant potential for non-invasive, continuous health monitoring, adhering conformally to the skin without signal crosstalk, and enabling real-time, high-fidelity signal transmission in human-machine interactions under cryogenic conditions. These ICHs offer transformative potential for the next generation of multimodal sensors, broadening application possibilities in harsh environments, including extreme weather and outer space.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2412726"},"PeriodicalIF":14.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging Network Target Theory for Efficient Prediction of Drug-Disease Interactions: A Transfer Learning Approach.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202409130

Qingyuan Liu, Zizhen Chen, Boyang Wang, Boyu Pan, Zhuoyu Zhang, Miaomiao Shen, Weibo Zhao, Tingyu Zhang, Shao Li, Liren Liu

{"title":"Leveraging Network Target Theory for Efficient Prediction of Drug-Disease Interactions: A Transfer Learning Approach.","authors":"Qingyuan Liu, Zizhen Chen, Boyang Wang, Boyu Pan, Zhuoyu Zhang, Miaomiao Shen, Weibo Zhao, Tingyu Zhang, Shao Li, Liren Liu","doi":"10.1002/advs.202409130","DOIUrl":"https://doi.org/10.1002/advs.202409130","url":null,"abstract":"Efficient virtual screening methods can expedite drug discovery and facilitate the development of innovative therapeutics. This study presents a novel transfer learning model based on network target theory, integrating deep learning techniques with diverse biological molecular networks to predict drug-disease interactions. By incorporating network techniques that leverage vast existing knowledge, the approach enables the extraction of more precise and informative drug features, resulting in the identification of 88,161 drug-disease interactions involving 7,940 drugs and 2,986 diseases. Furthermore, this model effectively addresses the challenge of balancing large-scale positive and negative samples, leading to improved performance across various evaluation metrics such as an Area under curve (AUC) of 0.9298 and an F1 score of 0.6316. Moreover, the algorithm accurately predicts drug combinations and achieves an F1 score of 0.7746 after fine-tuning. Additionally, it identifies two previously unexplored synergistic drug combinations for distinct cancer types in disease-specific biological network environments. These findings are further validated through in vitro cytotoxicity assays, demonstrating the potential of the model to enhance drug development and identify effective treatment regimens for specific diseases.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2409130"},"PeriodicalIF":14.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal Neutron Spectrum Database for In-reactor ²³⁸Pu Production.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202410995

Qingquan Pan, Xiaojing Liu, Yun Cai

{"title":"Optimal Neutron Spectrum Database for In-reactor 238Pu Production.","authors":"Qingquan Pan, Xiaojing Liu, Yun Cai","doi":"10.1002/advs.202410995","DOIUrl":"https://doi.org/10.1002/advs.202410995","url":null,"abstract":"Plutonium-238 (238Pu) is a scarce heat-source radioisotope used in nuclear batteries, which is produced by in-reactor irradiation of Americium-241 (241Am) or Neptunium-237 (237Np). Optimizing the neutron spectrum can improve the production efficiency of 238Pu, but currently, it is still a lack of knowledge about the optimal neutron spectrum for 238Pu production. Genetic algorithms and burnup algorithms are combined to identify optimal neutron spectra for 238Pu production under various irradiation times and flux levels, and build an optimal neutron spectrum database, which answers the questions \"What is the optimal neutron spectrum for 238Pu production?\" and \"What is the maximum efficiency for 238Pu production\" once and for all. This database can be referred to for determining the optimal neutron spectrum, guiding the neutron spectrum regulation process to improve the yield of 238Pu. Moreover, these results find that the production method of in-reactor irradiation 237Np not only has a higher yield but also achieves a higher purity of 238Pu than that of in-reactor irradiation 241Am, which conflicts with the traditional experiences, providing with previously unknown insights and helping break through the efficiency limit of traditional methods, maximizing 238Pu production.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2410995"},"PeriodicalIF":14.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspartate Metabolism-Driven Gut Microbiota Dynamics and RIP-Dependent Mitochondrial Function Counteract Oxidative Stress.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202404697

Shunshun Jin, Jian Wu, Chenyu Wang, Yiwen He, Yulong Tang, Le Huang, Hui Zhou, Di Liu, Ziping Wu, Yanzhong Feng, Heshu Chen, Xinmiao He, Guan Yang, Can Peng, Jiazhang Qiu, Tiejun Li, Yulong Yin, Liuqin He

{"title":"Aspartate Metabolism-Driven Gut Microbiota Dynamics and RIP-Dependent Mitochondrial Function Counteract Oxidative Stress.","authors":"Shunshun Jin, Jian Wu, Chenyu Wang, Yiwen He, Yulong Tang, Le Huang, Hui Zhou, Di Liu, Ziping Wu, Yanzhong Feng, Heshu Chen, Xinmiao He, Guan Yang, Can Peng, Jiazhang Qiu, Tiejun Li, Yulong Yin, Liuqin He","doi":"10.1002/advs.202404697","DOIUrl":"https://doi.org/10.1002/advs.202404697","url":null,"abstract":"Aspartate (Asp) metabolism-mediated antioxidant functions have important implications for neonatal growth and intestinal health; however, the antioxidant mechanisms through which Asp regulates the gut microbiota and influences RIP activation remain elusive. This study reports that chronic oxidative stress disrupts gut microbiota and metabolite balance and that such imbalance is intricately tied to the perturbation of Asp metabolism. Under normal conditions, in vivo and in vitro studies reveal that exogenous Asp improves intestinal health by regulating epithelial cell proliferation, nutrient uptake, and apoptosis. During oxidative stress, Asp reduces Megasphaera abundance while increasing Ruminococcaceae. This reversal effect depends on the enhanced production of the antioxidant eicosapentaenoic acid mediated through Asp metabolism and microbiota. Mechanistically, the application of exogenous Asp orchestrates the antioxidant responses in enterocytes via the modulation of the RIP3-MLKL and RIP1-Nrf2-NF-κB pathways to eliminate excessive reactive oxygen species and maintain mitochondrial functionality and cellular survival. These results demonstrate that Asp signaling alleviates oxidative stress by dynamically modulating the gut microbiota and RIP-dependent mitochondrial function, providing a potential therapeutic strategy for oxidative stress disease treatment.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2404697"},"PeriodicalIF":14.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observations of Cherenkov-Like Radial Wake in Water Waves.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202412638

Zijian Qin, Lian Shen, Yihao Yang, Hongsheng Chen, Huaping Wang

引用次数: 0

Peptide-Perovskite Based Bio-Inspired Materials for Optoelectronics Applications.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202408919

Samrana Kazim, M P U Haris, Shahzada Ahmad

{"title":"Peptide-Perovskite Based Bio-Inspired Materials for Optoelectronics Applications.","authors":"Samrana Kazim, M P U Haris, Shahzada Ahmad","doi":"10.1002/advs.202408919","DOIUrl":"https://doi.org/10.1002/advs.202408919","url":null,"abstract":"The growing demand for environmentally friendly semiconductors that can be tailored and developed easily is compelling researchers and technologists to design inherently bio-compatible, self-assembling nanostructures with tunable semiconducting characteristics. Peptide-based bioinspired materials exhibit a variety of supramolecular morphologies and have the potential to function as organic semiconductors. Such biologically or naturally derived peptides with intrinsic semiconducting characteristics create new opportunities for sustainable biomolecule-based optoelectronics devices. Affably, halide perovskite nanocrystals are emerging as potentially attractive nano-electronic analogs, in this vein creating synergies and probing peptide-perovskite-based bio-electronics are of paramount interest. The physical properties and inherent aromatic short-peptide assemblies that can stabilize, and passivate the defects at surfaces assist in improving the charge transport in halide perovskite devices. This review sheds light on how these peptide-perovskite nano-assemblies can be developed for optical sensing, optoelectronics, and imaging for biomedical and healthcare applications. The charge transfer mechanism in peptides along with as an outlook the electron transfer mechanism between perovskite and short peptide chains, which is paramount to facilitate their entry into molecular electronics is discussed. Future aspects, prevailing challenges, and research directions in the field of perovskite-peptides are also presented.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2408919"},"PeriodicalIF":14.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonlinear Harmonics: A Gateway to Enhanced Image Contrast and Material Discrimination.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202411556

Pardis Biglarbeigi, Gourav Bhattacharya, Dewar Finlay, Amir Farokh Payam

{"title":"Nonlinear Harmonics: A Gateway to Enhanced Image Contrast and Material Discrimination.","authors":"Pardis Biglarbeigi, Gourav Bhattacharya, Dewar Finlay, Amir Farokh Payam","doi":"10.1002/advs.202411556","DOIUrl":"https://doi.org/10.1002/advs.202411556","url":null,"abstract":"Recent advancements in atomic force microscopy (AFM) have enabled detailed exploration of materials at the molecular and atomic levels. These developments, however, pose a challenge: the data generated by microscopic and spectroscopic experiments are increasing rapidly in both size and complexity. Extracting meaningful physical insights from these datasets is challenging, particularly for multilayer heterogeneous nanoscale structures. In this paper, an unsupervised approach is presented to enhance AFM image contrast by analyzing the nonlinear response of a cantilever interacting with a material's surface using a wavelet-based AFM. This method simultaneously measures different frequencies and harmonics in a single scan, without the need for additional hardware and exciting multiple cantilevers' eigenmodes. This developed AFM image contrast enhancement (AFM-ICE) approach employs unsupervised learning, image processing, and image fusion techniques. The method is applied to interpret complex multilayer structures consist of defects, deposited nanoparticles and heterogeneities. Its substantial capability is demonstrated to improve image contrast and differentiate between various components. This methodology can pave the way for rapid and precise determination of material properties with enhanced resolution.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2411556"},"PeriodicalIF":14.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to [Tumor-Associated Macrophage-Derived Exosomes LINC01232 Induce the Immune Escape of Glioma by Decreasing MHC-I Surface Expression].

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202500268

引用次数: 0

Large-Area Conductor-Loaded PDMS Flexible Composites for Wireless and Chipless Electromagnetic Multiplexed Temperature Sensors.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202412066

Benjamin King, Nikolas Bruce, Mahmoud Wagih

{"title":"Large-Area Conductor-Loaded PDMS Flexible Composites for Wireless and Chipless Electromagnetic Multiplexed Temperature Sensors.","authors":"Benjamin King, Nikolas Bruce, Mahmoud Wagih","doi":"10.1002/advs.202412066","DOIUrl":"https://doi.org/10.1002/advs.202412066","url":null,"abstract":"Capacitive dielectric temperature sensors based on polydimethylsiloxane (PDMS) loaded with 10 vol% of inexpensive, commercially-available conductive fillers including copper, graphite, and milled carbon fiber (PDMS-CF) powders are reported. The sensors are tested in the range of 20-110 °C and from 0.5 to 200 MHz, with enhanced sensitivity from 20 to 60 °C, and a relative response of 85.5% at 200 MHz for PDMS-CF capacitors. PDMS-CF capacitors are interrogated as a sensing element in wirelessly coupled chipless resonant coils tuned to 6.78 MHz with a response in the resonant frequency (fr) of the sensor, demonstrating an average sensitivity of 0.38% °C-1, a 40x improvement over a pristine PDMS capacitive sensor and outperforms state-of-the-art frequency-domain radio frequency temperature sensors. Exploiting its high sensitivity, the wireless sensing platform is interrogated using a low-cost, portable, and open-source NanoVNA demonstrating a relative response in fr of 48.5%, good agreement with instrumentation-grade vector network analyzers (VNAs) and negligible change in performance at a range of reading distances and humidities. Finally, a wireless tag is demonstrated with rapid, reversible dynamic response to changes in temperature, as well as the in the first scalable, multiplexed array of chipless sensors for spatial temperature detection.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2412066"},"PeriodicalIF":14.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0