Advanced SciencePub Date : 2025-07-28DOI: 10.1002/advs.202509287
Van Truc Ngo, Karan Gulati, Cheryl Suwen Law, Nguyen Que Huong Tran, Jingkai Lin, Damian L Stachura, Andrew D Abell, Huayang Zhang, Abel Santos
{"title":"Titania Nanopores as Photoelectrocatalysts for Coupling Hydrogen Production with Plastic Reformation.","authors":"Van Truc Ngo, Karan Gulati, Cheryl Suwen Law, Nguyen Que Huong Tran, Jingkai Lin, Damian L Stachura, Andrew D Abell, Huayang Zhang, Abel Santos","doi":"10.1002/advs.202509287","DOIUrl":"https://doi.org/10.1002/advs.202509287","url":null,"abstract":"<p><p>Photoelectrochemical (PEC) water splitting offers a sustainable pathway for solar-to-chemical energy conversion, yet its efficiency is often limited by sluggish water oxidation and the generation of low-value oxygen. Here, the use of engineered titania nanopore (TNP) films is reported, fabricated via anodization and thermal annealing, as co-catalyst-free photoanodes for coupling hydrogen evolution reaction (HER) with polyethylene terephthalate (PET) reformation into high-value formate. By tuning the crystallographic phase of TiO<sub>2</sub> from amorphous to anatase and rutile, the optimized anatase-phase electrode exhibits excellent PEC performance in a two-electrode configuration, achieving a high steady-state photocurrent density of [2.34 ± 0.67] mA cm<sup>-2</sup>, a hydrogen evolution output of 1771 ± 30 µL cm<sup>-2</sup>, a formate yield of 1.68 ± 0.05 mmol L<sup>-1</sup>, and a Faradaic efficiency of 85 ± 9.0%. Notably, despite the absence of noble metals or complex heterostructures, the PEC performance of the TNP films is comparable to, or even surpasses, that of reported systems employing additional co-catalysts. This study establishes a simple and scalable PEC platform for simultaneous green hydrogen production and plastic waste valorization, offering new opportunities for sustainable energy and environmental technologies.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e09287"},"PeriodicalIF":14.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-07-28DOI: 10.1002/advs.202502793
Tao Wang, Li Wang, Jian Sun, Yan Chen, Waseem Ali, Yonggang Ma, Ruilong Song, Xishuai Tong, Jiaqiao Zhu, Yan Yuan, Jianhong Gu, Jianchun Bian, Zongping Liu, Hui Zou
{"title":"Tunneling Nanotube-Mediated Transcellular Autophagy Alleviates Cadmium Induced Hepatocyte Injury.","authors":"Tao Wang, Li Wang, Jian Sun, Yan Chen, Waseem Ali, Yonggang Ma, Ruilong Song, Xishuai Tong, Jiaqiao Zhu, Yan Yuan, Jianhong Gu, Jianchun Bian, Zongping Liu, Hui Zou","doi":"10.1002/advs.202502793","DOIUrl":"https://doi.org/10.1002/advs.202502793","url":null,"abstract":"<p><p>Cadmium (Cd) exposure is strongly linked to various diseases and dysregulation of autophagy is a pivotal mechanism in Cd toxicity. Targeted autophagy strategies are promising for the treatment of autophagy dysregulation-related diseases, including Cd poisoning. However, the current understanding of autophagy mechanisms remains limited, hindering the development of effective strategies. Herein, a novel autophagy pathway, transcellular autophagy. Cd triggers this process in hepatocytes, facilitating the transfer of autophagosomes from damaged to healthy cells for degradation. Mechanistically, reactive oxygen species accumulation is a key driver of transcellular autophagy activation, while the disruption of autophagy fusion mechanisms triggers its activation. Notably, Cd-induced transcellular autophagy relies on the tumor necrosis factor, alpha-induced protein 2 (TNFAIP2)-tunneling nanotube (TNT) system. Blocking this system prevents autophagosome transfer and exacerbates Cd-induced autophagosome overload and apoptosis. The findings offer a novel perspective on autophagy, and provide new insights for targeted autophagy strategies to treat Cd poisoning and autophagy dysregulation-related diseases.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e02793"},"PeriodicalIF":14.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Decoding Handwriting Trajectories from Intracortical Brain Signals for Brain-to-Text Communication.","authors":"Guangxiang Xu, Zebin Wang, Kedi Xu, Junming Zhu, Jianmin Zhang, Yueming Wang, Yaoyao Hao","doi":"10.1002/advs.202505492","DOIUrl":"https://doi.org/10.1002/advs.202505492","url":null,"abstract":"<p><p>The potential to decode handwriting trajectories from brain signals has yet to be fully explored in clinical brain-computer interfaces (BCIs). Here, intracortical neural signals are recorded from a paralyzed individual during attempted handwriting of complex characters. An innovative decoding framework is introduced to address both shape and temporal distortions between neural activity and movement, effectively resolving the misalignment issue commonly encountered in clinical BCIs due to the lack of accurate movement labels. The results demonstrated the reconstruction of highly accurate and human-recognizable handwriting trajectories, significantly outperforming conventional methods. Furthermore, the new framework enabled effective multi-day data fusion, leading to additional improvements in trajectory quality. By employing a dynamic time warping approach to translate trajectories into text, a recognition rate up to 91.1% is achieved within a 1000-character database. Additionally, the framework is applied to reconstruct single-trial trajectories of English letters using a previously published dataset, achieving similarly high recognition rates. Collectively, these findings present a novel BCI decoding scheme capable of accurately reconstructing handwriting trajectories, demonstrating its applicability to both alphabetic and logographic brain-to-text translation. This approach has the potential to revolutionize communication for individuals with motor impairments by enabling accurate brain-to-text translation across diverse languages.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e05492"},"PeriodicalIF":14.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-07-28DOI: 10.1002/advs.202500320
Deepthy Kavungal, Enzo Morro, Senthil T Kumar, Berkay Dagli, Hilal A Lashuel, Hatice Altug
{"title":"Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker-Based Drug Screening for Neurodegenerative Diseases.","authors":"Deepthy Kavungal, Enzo Morro, Senthil T Kumar, Berkay Dagli, Hilal A Lashuel, Hatice Altug","doi":"10.1002/advs.202500320","DOIUrl":"https://doi.org/10.1002/advs.202500320","url":null,"abstract":"<p><p>The misfolding of proteins from native monomers into β-sheet-rich fibrils via oligomers is a key hallmark of neurodegenerative diseases (NDDs). Identifying and screening drugs that inhibit protein aggregation for early disease intervention remains challenging due to the limitations of existing methods. This work introduces a novel nanoplasmonic infrared microarray sensor for label-free and high-throughput drug screening based on structural protein biomarkers in NDDs. The sensor employs 2D arrays of nanoplasmonic units compartmentalized in micropatterned polymeric microwells for high-throughput protein sensing and secondary structural analysis. The flexibility of the on-chip integrated microarray sensor is showcased through ultra-compact 48, 96, and 384 microwell designs, enabling detection from as low as 2 nL of sample volume and with a 100 pg/mL sensitivity in under a minute of in situ measurement. The drug screening capability is validated by assessing multiple drug compounds in a multiplexed manner for their inhibiting effect on aSyn aggregation, an important NDDs protein biomarker. The microarray sensor successfully quantified the secondary structural changes in drug-treated protein samples, detecting both oligomers and fibrils, which the conventional fluorescence-based assays failed to do. Thus, the nanoplasmonic microarray sensor is a promising advancement in the NDDs and pharmaceutical research for drug screening.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e00320"},"PeriodicalIF":14.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice.","authors":"Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J Kenny, Zuxin Chen, Xin-An Liu","doi":"10.1002/advs.202415311","DOIUrl":"https://doi.org/10.1002/advs.202415311","url":null,"abstract":"<p><p>The effects of nicotine on aging-related motor and cognitive decline remain controversial due to limited empirical evidence. Here, mice are permitted to orally consume nicotine over a 22-month period and observed attenuated motor decline without pathological alterations in major metabolism-related peripheral organs or immune system dysfunction. Multi-organ metabolomic profiling and network analysis of aged mice (24 months old) identified nicotine-responsive pathways related to glycolipid metabolism and energy homeostasis. Dynamic gut microbiota profiling via series expression miner-based longitudinal analysis reveals that nicotine consumption preserved microbiota composition and altered microbial-derived metabolites associated with the sphingolipid pathway, known to regulate age-related muscle dysfunction and sarcopenia. Assays in aged mice and C2C12 cells confirmed that nicotine regulates sphingolipid turnover, particularly via sphingomyelin synthases and neutral sphingomyelinases, to enhance nicotinamide adenine dinucleotide availability and energy metabolism. These metabolic adaptations correlated with reduced ceramide accumulation and improved motor function. Behavior-Metabolome Age (BMAge) score confirmed a biologically younger phenotype in the nicotine-treated mice. Together, these findings suggest that life-long oral nicotine consumption reprograms aging-associated metabolism through regulation of systemic sphingolipid homeostasis, conferring resilience against age-related motor decline.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e15311"},"PeriodicalIF":14.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-07-28DOI: 10.1002/advs.202508335
Kaidong Song, Qian Wu, Ashley M Compaan, Junting Shen, Chuanshen Zhou, Mingwei Chen, Marc Sole-Gras, John-Thomas T Robinson, Bing Ren, Huayong Yang, Yong Huang, Jun Yin
{"title":"Solvent-Rich Pre-Coagulation Bath for Tunable Liquid-State Fusion Enables Robust Two-Step Polymer Embedded Printing.","authors":"Kaidong Song, Qian Wu, Ashley M Compaan, Junting Shen, Chuanshen Zhou, Mingwei Chen, Marc Sole-Gras, John-Thomas T Robinson, Bing Ren, Huayong Yang, Yong Huang, Jun Yin","doi":"10.1002/advs.202508335","DOIUrl":"https://doi.org/10.1002/advs.202508335","url":null,"abstract":"<p><p>Effective interlayer fusion is a critical step enabling a 3D printing process. For engineering polymer printing, interlayer fusion is usually either heat-enabled or binder-based, which may introduce thermal residual stress, warpage, and undesirable impurities. To overcome such challenges, a two-step immersion phase separation (IPS)-based room-temperature polymer fusion and solidification approach for self-supported engineering polymer printing, termed IPS-embedded 3D printing (IPS-E3DP) is introduced. IPS-E3DP is implemented by first depositing polymer inks in a solvent-rich yield-stress pre-coagulation support bath to have an intermediate green part and then immersing the intermediate green part in a non-solvent coagulation bath for complete solidification. During the first critical step, dissolved polymer ink holds its deposited shape and fuses with a previously deposited polymeric feature in the pre-coagulation support bath. Specifically, it is the high-concentration solvent bath (usually 80% or higher) that enables tunable liquid-state fusion of polymers when the deposited polymer solidifies, and it is the yield-stress support bath that prevents the deposited polymer ink from spreading and deformation during fusion. IPS-E3DP enables the self-supported room-temperature high-fidelity printing of a wide range of engineering polymers, blends, and composites with superior geometric complexity. The process can be tailored as a polymer binder-based printing approach for versatile material printing.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e08335"},"PeriodicalIF":14.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"m<sup>6</sup>A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control.","authors":"Lisha Yin, Yuting Zhang, Bingqian Zhang, Jin Zhang, Mengneng Xiong, Nan Jiang, Jinxin Xiao, Huihui Gao, Wenjing Xiong, Xiaoli Wang, Fengli Wang, Shuiqiao Yuan","doi":"10.1002/advs.202506600","DOIUrl":"https://doi.org/10.1002/advs.202506600","url":null,"abstract":"<p><p>N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) reader proteins have been demonstrated to be involved in numerous biological processes. However, the regulatory mechanism of specific m<sup>6</sup>A reader proteins during mammalian meiotic processes remains largely elusive. Here, this study identified hnRNPA2B1 as an m<sup>6</sup>A reader protein that plays a critical role in meiotic pachytene progression using a tamoxifen-induced knockout mouse model. Deletion of hnRNPA2B1 in spermatocytes disrupts homologous recombination and synapsis, with the mislocalization of double-strand break (DSB) repair proteins beyond the chromosome axes in pachytene spermatocytes. Multi-omics analyses revealed extensive dysregulation of the transcriptome and proteome in hnRNPA2B1-deficient spermatocytes, particularly affecting genes involved in chromosome organization, meiotic cell cycle, and DNA damage response, thereby triggering the pachytene checkpoint for cell elimination. In vitro luciferase assays confirmed that hnRNPA2B1 directly targets several meiosis-related transcripts (e.g., Ep400, Rrs1, etc.) in an m<sup>6</sup>A-dependent manner to regulate their expression. Furthermore, this finding demonstrates that hnRNPA2B1 biologically interacts with mRNA processing regulators and translation factors (e.g., eIF4G3, RPS3, RPL13, DDX5, YTHDC2) and functions as a post-transcriptional factor essential for pachytene progression during male meiosis. Collectively, this study underscores the critical role of the m<sup>6</sup>A reader hnRNPA2B1 in the pachytene checkpoint and advances our understanding of the regulatory mechanisms underlying male meiosis.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e06600"},"PeriodicalIF":14.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-07-28DOI: 10.1002/advs.202500102
Wei-Peng Hu, Ze-Yu Cai, Qing-Le Li, Tao Zhang, Xiang-Yu Chu, Chang Wang, Qing-Yi Zhang, Rong Qi
{"title":"PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination.","authors":"Wei-Peng Hu, Ze-Yu Cai, Qing-Le Li, Tao Zhang, Xiang-Yu Chu, Chang Wang, Qing-Yi Zhang, Rong Qi","doi":"10.1002/advs.202500102","DOIUrl":"https://doi.org/10.1002/advs.202500102","url":null,"abstract":"<p><p>Aortic aneurysm and dissection (AAD) are life-threatening cardiovascular diseases with limited effective medical treatments. Protein phosphatase 2A (PP2A), the most abundant serine/threonine phosphatase in eukaryotes, is pivotal in regulating intracellular signaling. This study investigates the role of PP2A in the pathogenesis of AAD. Analysis of available datasets revealed that PP2Acα is the most significantly downregulated PP2A subunit in human and mouse aneurysm tissues. Vascular smooth muscle cell (VSMC)-specific PP2Acα knockout exacerbates β-Aminopropionitrile (BAPN)-induced aortic dissection and elastase-induced abdominal aortic aneurysm in mice. Collagen-based contraction assays, Western blot, and gelatin zymography confirmed that the deficiency of PP2Acα results in decreased contractility, contractile markers, and elevated production of matrix metallopeptidase 2 (MMP2) in VSMCs. Furthermore, PP2Acα deficiency promoted VSMC phenotypic switching through stabilizing Kruppel-like factor 4 (KLF4). Mechanistically, PP2Acα binds to and dephosphorylates protein kinase B 1 (AKT1), thereby reducing phosphorylation of the AKT1 substrate KLF4 at Thr398. The deficiency of PP2Acα diminishes KLF4 phosphorylation-dependent ubiquitination and degradation, leading to the suppression of VSMC contractile gene transcription. The findings underscore a critical role for PP2Acα in regulating VSMC phenotypic switching and AAD progression by controlling KLF4 phosphorylation and ubiquitination, offering novel insights into the molecular pathogenesis underlying AAD.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e00102"},"PeriodicalIF":14.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surface-Exposed Pd Nanocluster Confined within a Ring-Shaped Polyoxometalate for Selective Hydrogenation.","authors":"Rui Xi, Kentaro Yonesato, Takafumi Yatabe, Yoshihiro Koizumi, Soichi Kikkawa, Seiji Yamazoe, Koji Harano, Kazuya Yamaguchi, Kosuke Suzuki","doi":"10.1002/advs.202509418","DOIUrl":"https://doi.org/10.1002/advs.202509418","url":null,"abstract":"<p><p>Developing efficient catalysts for selective hydrogenation of molecules bearing multiple reducible functional groups remains a major challenge. Palladium (Pd) nanoclusters are promising candidates owing to their strong H<sub>2</sub> activation ability, broad substrate compatibility, and unique surface properties. However, the controlled synthesis of small Pd nanoclusters with accessible, coordinatively unsaturated active sites remains difficult as they are prone to aggregation. In this study, a strategy is presented to fabricate surface-exposed Pd nanoclusters confined within a ring-shaped polyoxometalate (POM) via a mild solid-state reduction process (1 atm H<sub>2</sub>, ≈25 °C). The resulting Pd nanocluster exhibits exceptional chemoselectivity in the hydrogenation of multifunctional substrates by preferentially adsorbing C═C and C≡C bonds on its discrete, exposed Pd surface with a well-defined coordination environment. Importantly, the rigid POM framework considerably stabilizes Pd nanocluster, enabling excellent reusability over multiple catalytic cycles. This study demonstrates a molecular templating approach for constructing robust and chemoselective metal nanocluster catalysts, offering new opportunities in the design of hydrogenation systems.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e09418"},"PeriodicalIF":14.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-07-28DOI: 10.1002/advs.202506557
Yue Zhao, Xiaopeng Cheng, Ran Zhao, Xipeng Li, Jingxin Meng, Shutao Wang
{"title":"Recent Advances of Microcapsule-based Intelligent Coatings: From Bioinspired Designs, Material Selections, to Potential Applications.","authors":"Yue Zhao, Xiaopeng Cheng, Ran Zhao, Xipeng Li, Jingxin Meng, Shutao Wang","doi":"10.1002/advs.202506557","DOIUrl":"https://doi.org/10.1002/advs.202506557","url":null,"abstract":"<p><p>Coating technology is widely used in diverse fields such as energy, healthcare, and aerospace because of the advantages of simple fabrication, low cost, stability, and customized functions. However, conventional coatings fall short in meeting the emerging demands due to their single functionality and non-responsiveness. Inspired by natural prototypes, microcapsule-based intelligent coatings (MICs) that exhibit remarkable responsiveness to external stimuli have been developed and used in various fields such as corrosion protection and anti-fouling. Comprehensively understanding the responsive mechanisms and optimization strategies of MICs can maximize their adaptability and flexibility, which are highly desired for their precise preparation and actual applications. Therefore, this review focuses on recent progress of MICs, varying from bioinspired designs, material selections, stimulus responses, and diverse applications, providing more inspiration to design advanced MICs. First, biological prototypes used in the fabrication of MICs are briefly introduced. Then, the material selections and stimulus responses of MICs, as well as their advantages and disadvantages are emphasized. Later, applications are focused according to their functions, including anti-corrosion, anti-fouling, self-lubricating, and temperature regulation. Finally, the scientific challenges and prospects in designing MICs, focusing on the requirements of developing new structures using machine learning and achieving new applications, are highlighted.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e06557"},"PeriodicalIF":14.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}