Advanced Science最新文献_第8页

Correction to "Inhibition of CDH11 Activates cGAS-STING by Stimulating Branched Chain Amino Acid Catabolism and Mitigates Lung Metastasis of Adenoid Cystic Carcinoma". 更正“抑制CDH11通过刺激支链氨基酸分解代谢激活cGAS-STING，减轻腺样囊性癌肺转移”。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202504992

引用次数: 0

Kinetically Limited Growth of Dendritic Tin Oxide Thin Films: a Machine Learning Study beyond the Structure Zone Diagram. 枝晶氧化锡薄膜的动力学受限生长：结构区图以外的机器学习研究。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202504627

Denis Music, Xuelian Xiao, Rami Naser, Keke Chang, Grzegorz Sadowski, Pär A T Olsson

{"title":"Kinetically Limited Growth of Dendritic Tin Oxide Thin Films: a Machine Learning Study beyond the Structure Zone Diagram.","authors":"Denis Music, Xuelian Xiao, Rami Naser, Keke Chang, Grzegorz Sadowski, Pär A T Olsson","doi":"10.1002/advs.202504627","DOIUrl":"https://doi.org/10.1002/advs.202504627","url":null,"abstract":"Even after fifty years since its introduction, the empirical Thornton's structure zone diagram remains a valuable tool for predicting thin film microstructure. This diagram is essential for understanding the correlation between synthesis, composition, structure, and physical properties in emerging applications. In this work, we critically appraise this diagram by examining Sn─O thin films grown at room temperature using reactive magnetron sputtering. Based on transmission electron microscopy, Sn0.6O0.4 thin films form dendrites featuring nanosized Sn and SnO grains, rather than columns, which are not captured by the structure zone diagram. Using density functional theory and machine learning, we constructed a model to explain this unusual microstructure on the atomic scale. Kinetically limited surface diffusion yields SnO islands on Sn(001), which constitute the initial stage of dendrite formation. This study provides the potential to devise models for thin film microstructure evolution, enhancing performance in advanced applications, such as green energy generation and storage.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e04627"},"PeriodicalIF":14.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecularly Engineered Hydrogel Electrolyte Embedded with Multifunctional Oxygen-Rich Macrocyclic Units for Uniform Zinc Deposition. 嵌入多功能富氧大环单元的分子工程水凝胶电解质用于均匀锌沉积。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202507377

Miao Sun, Guochen Ji, Meizhi Li, Junping Zheng

{"title":"Molecularly Engineered Hydrogel Electrolyte Embedded with Multifunctional Oxygen-Rich Macrocyclic Units for Uniform Zinc Deposition.","authors":"Miao Sun, Guochen Ji, Meizhi Li, Junping Zheng","doi":"10.1002/advs.202507377","DOIUrl":"https://doi.org/10.1002/advs.202507377","url":null,"abstract":"Hydrogel electrolyte has emerged as an effective strategy for stabilizing zinc anode. Despite certain advancements in network design, solely relying on simple combinations of traditional polymer chains or single-function monomers is far from satisfactory in overcoming multiple challenges faced by zinc-ion battery. Herein, a novel multifunctional monomer, benzo-15-crown-5-acrylamide (BCAm), is designed and introduced into hydrogel network (PBCM-HE), aiming to regulate solvation sheath structure with supramolecular macrocyclic units. Specifically, rigid benzene rings in BCAm units can stabilize conformation of crown ether and bestow PBCM-HE excellent mechanical properties with tensile-strength of 105 kPa and compressive-strength of 0.6 MPa. Critically, the locally electron-rich ether bonds in supramolecular macrocycle can optimize solvation structure of hydrated zinc ions and promote ion transport, stabilizing interface interaction between electrolyte and Zn anode. Given this, PBCM-HE possesses outstanding ionic conductivity (61.7 mS cm-1) and remarkable transference number (0.86). Besides, the Zn||PBCM-HE||MnO2 full cells show excellent discharge specific capacity of 290.9 mAh g-1 at 0.1 C with Zn uniform deposition. This work innovatively develops a novel hydrogel electrolyte network with multifunctional monomer through one-step polymerization, providing new insights and possibilities for monomer design and selection in hydrogel electrolytes, further paving the way for exploring high-performance electrolytes in zinc-based devices.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e07377"},"PeriodicalIF":14.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tunable Polariton Rabi Oscillation in Phase-Changing Perovskite Microcavities (Adv. Sci. 20/2025) 相变钙钛矿微腔的可调谐极化激元拉比振荡（Sci. 20/2025）

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202570154

Hyeon-Seo Choi, Minjee Ko, Taejin Lee, Jin-Woo Jung, Young-Jun Lee, Hyeonjong Jeong, Youngjae Kim, Dongha Kim, Jinhee Heo, Shinbuhm Lee, JaeDong Lee, Chang-Hee Cho

引用次数: 0

Bi-Functional Diaminopropane Additive Enables Stable Li Anodes and Highly Efficient Cathodes for High-Performance Li-Air Batteries. 双功能二氨基丙烷添加剂为高性能锂空气电池提供稳定的锂阳极和高效的阴极。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-29 DOI: 10.1002/advs.202505539

Honghao Hu, Qingxu Zhang, Jiucong Liu, Junjie Li, Pingli Wu, Caicai Li, Peipei Du, Huiqiao Li, Xizheng Liu

{"title":"Bi-Functional Diaminopropane Additive Enables Stable Li Anodes and Highly Efficient Cathodes for High-Performance Li-Air Batteries.","authors":"Honghao Hu, Qingxu Zhang, Jiucong Liu, Junjie Li, Pingli Wu, Caicai Li, Peipei Du, Huiqiao Li, Xizheng Liu","doi":"10.1002/advs.202505539","DOIUrl":"https://doi.org/10.1002/advs.202505539","url":null,"abstract":"Low round-trip efficiency and limited cycle durability remain significant challenges for commercial of Lithium-air batteries (LABs). This study introduces a novel electrolyte additive, diaminopropane (DAP), that simultaneously addresses anode stability and cathode reaction kinetics in ambient LABs. The proposed mechanism involves a bi-function approach: 1) at the anode, DAP spontaneously reacts with metallic Li to form Li-DAP, which subsequently cross-links with ether solvents to create a protective gel layer. This layer effectively mitigates Li dendrite formation and shields the anode from ambient moisture and CO2 corrosion. 2) At the cathode, DAP modifies the oxygen reduction pathway from surface-mediated to solution-mediated, while simultaneously acting as an efficient redox mediator during charging. This dual functionality results in a remarkable reduction of the initial charging potential from 4.2 to 3.4 V, accompanied by observed singlet oxygen quenching. The implemented DAP additive enables LABs to achieve unprecedented cycling stability, demonstrating continuous operation for 1000 h in ambient air while maintaining energy efficiency exceeding 70%. This work establishes an effective electrolyte additive strategy for developing high-performance ambient LABs through simultaneous anode protection and enhanced cathode reaction reversibility.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e05539"},"PeriodicalIF":14.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery. 靶向肿瘤定殖和局部治疗递送的自我调节工程益生菌。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-28 DOI: 10.1002/advs.202406486

Zhen-Ping Zou, Xin-Ge Wang, Xuan-Ren Shi, Shu-Ting Sun, Jing Mi, Xiao-Peng Zhang, Bin-Cheng Yin, Ying Zhou, Bang-Ce Ye

{"title":"Self-Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery.","authors":"Zhen-Ping Zou, Xin-Ge Wang, Xuan-Ren Shi, Shu-Ting Sun, Jing Mi, Xiao-Peng Zhang, Bin-Cheng Yin, Ying Zhou, Bang-Ce Ye","doi":"10.1002/advs.202406486","DOIUrl":"https://doi.org/10.1002/advs.202406486","url":null,"abstract":"Engineered bacteria have demonstrated great potential for treating a broad array of tumors. However, the precision and safety of controlling the performance of engineered bacteria in vivo remains a central challenge. Here, genetic circuit programming strategy is utilized to construct an engineered Escherichia coli Nissle 1917 with accurate targeted colonizing and on-demand payloads releasing ability. The engineered probiotic survives only in the presence of more than 5 mM L-lactate by employing an improved lactate-sensing system, which leads to preventing the growth outside the permissive environments in mice. Meanwhile an expressing α-hemolysin (SAH) circuit based on quorum-sensing system is introduced to augment anti-tumor effect. Furthermore, coagulase (Coa) induced by high-level lactate creates the closure to deprive tumor of nutrients and oxygen and may help prevent the leakage of bacteria and SAH, which enhances the therapeutic effectiveness and biosafety. This self-adjusting living biotherapeutics significantly inhibits tumor proliferation and prolongs the survival time of colorectal tumor-bearing mice. Together, this work takes a step toward safer and more effective application of living bacteria for tumor treatment in practice.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e06486"},"PeriodicalIF":14.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum-infected Colorectal Cancer via Ecological Control. 定制功能性合成微生物群落通过生态控制缓解核梭杆菌感染的结直肠癌。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-28 DOI: 10.1002/advs.202414232

Zhongkun Zhou, Mengyue Yang, Hong Fang, Baizhuo Zhang, Yunhao Ma, Yongyuan Li, Yingjie Liu, Zeying Cheng, Yuanchun Zhao, Zhenzhen Si, Hongmei Zhu, Peng Chen

{"title":"Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum-infected Colorectal Cancer via Ecological Control.","authors":"Zhongkun Zhou, Mengyue Yang, Hong Fang, Baizhuo Zhang, Yunhao Ma, Yongyuan Li, Yingjie Liu, Zeying Cheng, Yuanchun Zhao, Zhenzhen Si, Hongmei Zhu, Peng Chen","doi":"10.1002/advs.202414232","DOIUrl":"https://doi.org/10.1002/advs.202414232","url":null,"abstract":"Polymorphic microbiomes play important roles in colorectal cancer (CRC) occurrence and development. In particular, Fusobacterium nucleatum (F. nucleatum) is prevalent in patients with CRC, and eliminating it is beneficial for treatment. Here, multiple metagenomic sequencing cohorts are combined with multiomics to analyze the microbiome and related functional alterations. Furthermore, local human metagenome and metabolomics are used to discover commensal consortia. A synthetic microbial community (SynCom) is then designed by metabolic network reconstruction, and its performance is validated using coculture experiments and an AOM-DSS induced mouse CRC model. The sequencing result shows that F. nucleatum is more abundant in both the feces and tumor tissues of CRC patients. It causes alterations through various pathways, including microbial dysbiosis, lipid metabolism, amino acid metabolism, and bile acid metabolism disorders. The designed SynCom contains seven species with low competition interrelationship. Furthermore, the SynCom successfully inhibits F. nucleatum growth in vitro and achieves colonization in vivo. Additionally, it promotes F. nucleatum decolonization, and enhances tryptophan metabolism and secondary bile acid conversion, leading to reduced lipid accumulation, decreased inflammatory reaction, and enhanced tumor inhibition effect. Overall, the bottom-up designed SynCom is a controllable and promising approach for treating F. nucleatum-positive CRC.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e14232"},"PeriodicalIF":14.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-Freezing-Temperature Golgi Neuronal Staining for X-ray Imaging of Human Brain. 近冰点温度高尔基神经元染色在人脑x射线成像中的应用。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-28 DOI: 10.1002/advs.202504468

Feng Zhou, Qiaowei Tang, Xin Yan, Chao Ma, Yu Zhang, Jichao Zhang, Qian Li, Lihua Wang, Jun Hu, Xiaoqing Cai, Jiang Li, Ying Zhu, Chunhai Fan

{"title":"Near-Freezing-Temperature Golgi Neuronal Staining for X-ray Imaging of Human Brain.","authors":"Feng Zhou, Qiaowei Tang, Xin Yan, Chao Ma, Yu Zhang, Jichao Zhang, Qian Li, Lihua Wang, Jun Hu, Xiaoqing Cai, Jiang Li, Ying Zhu, Chunhai Fan","doi":"10.1002/advs.202504468","DOIUrl":"https://doi.org/10.1002/advs.202504468","url":null,"abstract":"Achieving detailed neuronal structural information in large-volume brain tissue has been a longstanding challenge in human brain imaging. A key obstacle arises from the trade-off between staining efficiency and tissue autolysis. Traditional Golgi staining, typically conducted at room temperature or 37 °C to optimize staining efficiency, leads to rapid autolysis of brain tissue, resulting in the loss of fine structural details. Here, a near-freezing temperature (NFT) staining strategy in post-mortem frozen (PMF) human brain samples are presented, using a mercury chloride-based method under ice-water bath conditions. In contrast to the 37 °C Golgi staining, this NFT-based method significantly reduces tissue autolysis, preserving fine neuronal structures. Notably, neuronal counts in the same field of view increased by 5.5-fold, and dendritic spine density increases by 22-fold. Using this approach, uniform staining of millimeter-thick is achieved, centimeter-scale human brain slices and integrated it with synchrotron-based X-ray microscopy to perform micrometer resolution 3D reconstructions of the cerebellum and frontal lobe. This novel technique offers a powerful tool for the fine-structural imaging of large-volume brain tissue, providing new insights into the intricate organization of neural networks.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e04468"},"PeriodicalIF":14.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil-Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer. 模拟中性粒细胞的纳米药物消除肿瘤细胞内细菌，增强结直肠癌肝转移的化疗效果。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-28 DOI: 10.1002/advs.202504188

Yanan Niu, Xu Zhao, Yong Li, Xiaoya Ma, Weifeng Yang, Jie Ma, Wanglin Li, Wei Yuan

{"title":"Neutrophil-Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer.","authors":"Yanan Niu, Xu Zhao, Yong Li, Xiaoya Ma, Weifeng Yang, Jie Ma, Wanglin Li, Wei Yuan","doi":"10.1002/advs.202504188","DOIUrl":"https://doi.org/10.1002/advs.202504188","url":null,"abstract":"Fusobacterium nucleatum (Fn) enrichment has been identified in colorectal cancer and its liver metastases. In this study, we found that Fn predominantly accumulated within colorectal cancer cells, correlating with colorectal cancer liver metastasis. Clinically, the administration of high doses of antibiotics and chemotherapeutic agents can disrupt the balance of the host microbiota. To address this clinical challenge, metronidazole (MTI) and oxaliplatin (OXA) are encapsulated within poly (lactic-co-glycolic acid) (PLGA) nanoparticles. Neutrophil membrane vesicles are extracted from murine bone marrow and coated with these nanoparticles (NM@PLGA-MTI-OXA), creating neutrophil-mimetic nanoparticles with dual targeting capabilities for antibacterial and anticancer purposes. The neutrophil membrane coating, compared with free drugs, is found to enhance nanoparticle uptake by tumor cells, facilitating intracellular bacterial elimination and tumor cell death. Further experiments reveal that NM@PLGA-MTI-OXA reverses the Fn-induced epithelial-mesenchymal transition (EMT) in tumor cells during metastasis and remodels the immunosuppressive microenvironment, suppressing colorectal cancer and liver metastasis development while minimizing broad-spectrum damage to the commensal microbiota.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e04188"},"PeriodicalIF":14.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accurate Delivery of Mesenchymal Stem Cell Spheroids With Platelet-Rich Fibrin Shield: Enhancing Survival and Repair Functions of Sp-MSCs in Diabetic Wound Healing. 具有富血小板纤维蛋白屏蔽的间充质干细胞球体的准确递送：增强Sp-MSCs在糖尿病伤口愈合中的存活和修复功能。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-05-28 DOI: 10.1002/advs.202413430

Jinglve Zhang, Wenqing Xu, Yutian Xiao, Dingheng Su, Yusheng He, Huohong Yang, Yixin Xie, Xiaofang Wang, Ren-He Xu, Shaorong Lei, Dingyu Wu

{"title":"Accurate Delivery of Mesenchymal Stem Cell Spheroids With Platelet-Rich Fibrin Shield: Enhancing Survival and Repair Functions of Sp-MSCs in Diabetic Wound Healing.","authors":"Jinglve Zhang, Wenqing Xu, Yutian Xiao, Dingheng Su, Yusheng He, Huohong Yang, Yixin Xie, Xiaofang Wang, Ren-He Xu, Shaorong Lei, Dingyu Wu","doi":"10.1002/advs.202413430","DOIUrl":"https://doi.org/10.1002/advs.202413430","url":null,"abstract":"Diabetic wound is a significant clinical challenge, and stem cell therapy has shown great potential. This study explores the role of mesenchymal stem cell (MSC) spheroids (Sp-MSCs) in healing diabetic wounds and the use of autologous plasma-rich platelet fibrin (PRF) as a scaffold for Sp-MSCs. Through activation of the coagulation system, PRF offers a protective fibrin shield for Sp-MSCs to promote the rapid recovery migration and proliferation of MSCs while maintaining the activity of Sp-MSCs in an inflammatory overload environment by activating the related genes of Integrin-β1-vascular endothelial growth factor (VEGF), and Wnt/β-catenin pathways. The inclusion of Sp-MSCs accelerates the gelation of PRF and results in improved mechanical strength. Additionally, PRF enhances the repair function of Sp-MSCs, creating a favorable microenvironment for angiogenesis. In the wound model of diabetic mice, the combination of PRF with Sp-MSCs accelerates wound healing. Results show that this combination significantly promotes wound repair and regulates the immune microenvironment. The study suggests that PRF is a promising bio-derived scaffold for stem cell applications in diabetic wounds, offering new directions for stem cell therapy and biomimetic scaffold material development.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413430"},"PeriodicalIF":14.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0