Advanced Science最新文献_第7页

Top-Down Strategy Enabling Elastic Wood Nanocarbon Sponges with Wrinkled Multilayer Structure and High Compressive Strength for High-Performance Compressible Supercapacitors.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-29 DOI: 10.1002/advs.202410397

Song Wei, Caichao Wan, Xingong Li, Shanshan Jia, Ruwei Chen, Guanjie He, Yiqiang Wu

{"title":"Top-Down Strategy Enabling Elastic Wood Nanocarbon Sponges with Wrinkled Multilayer Structure and High Compressive Strength for High-Performance Compressible Supercapacitors.","authors":"Song Wei, Caichao Wan, Xingong Li, Shanshan Jia, Ruwei Chen, Guanjie He, Yiqiang Wu","doi":"10.1002/advs.202410397","DOIUrl":"https://doi.org/10.1002/advs.202410397","url":null,"abstract":"3D porous carbon electrodes have attracted significant attention for advancing compressible supercapacitors (SCs) in flexible electronics. The micro- and nanoscale architecture critically influences the mechanical and electrochemical performance of these electrodes. However, achieving a balance between high compressive strength, electrochemical stability, and cost-effective sustainable production remains challenging. Here, a superelastic wood nanocarbon sponge (WNCS) with a wrinkled multilayer structure is developed via a facile \"top-down\" design on natural wood. These unique wrinkled nanolayers effectively alleviate stress concentration through elastic deformation, resulting in a high compressive strength of 580.6 kPa at 70% reversible strain. The significantly increased specific surface area, coupled with abundant micro-mesopores and highly graphitized nanocarbon, promotes rapid ion/electron transport, enabling the WNCS to achieve an ultrahigh capacitance of 4.21 F cm-2 at 1 mA cm-2, along with excellent cyclic stability and rate capability. Furthermore, an asymmetric supercapacitor (ASC) using a WNCS anode and a NiCo-layered double hydroxide cathode retains 71.8% of its initial capacitance after 1000 compression cycles and withstands stress up to 1.03 MPa without capacitance degradation. This sustainable, cost-effective WNCS shows great promise for flexible, compressible, and wearable electrochemical energy systems.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2410397"},"PeriodicalIF":14.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable Stapling Peptide Based on Sulfonium as Universal Vaccine Adjuvants for Multiple Types of Vaccines.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-29 DOI: 10.1002/advs.202409567

Yaping Zhang, Chenshan Lian, Wenlong Lai, Leying Jiang, Yun Xing, Huiting Liang, Jin Li, Xinming Zhang, Jianhui Gan, Zigang Li, Feng Yin

{"title":"Programmable Stapling Peptide Based on Sulfonium as Universal Vaccine Adjuvants for Multiple Types of Vaccines.","authors":"Yaping Zhang, Chenshan Lian, Wenlong Lai, Leying Jiang, Yun Xing, Huiting Liang, Jin Li, Xinming Zhang, Jianhui Gan, Zigang Li, Feng Yin","doi":"10.1002/advs.202409567","DOIUrl":"https://doi.org/10.1002/advs.202409567","url":null,"abstract":"Adjuvants are non-specific immune enhancers commonly used to improve the responsiveness and persistence of the immune system toward antigens. However, due to the undefined chemical structure, toxicity, non-biodegradability, and lack of design technology in many existing adjuvants, it remains difficult to achieve substantive breakthroughs in the adjuvant research field. Here, a novel adjuvant development strategy based on stapling peptides is reported to overcome this challenge. The nano-vaccine incorporating peptide adjuvant and recombinant HBsAg protein not only induced strong antibody titers that are equivalent to aluminum adjuvanted vaccines but also simultaneously activated T-cell immune response. Similar results are also observed in herpes zoster vaccine and more complex influenza vaccine. The mechanism analysis demonstrates that antigen is efficiently carried into antigen-presenting cells (APCs) by peptide, further promoting the secretion of cytokines and activation of APCs. In addition, by redesigning the adjuvant, it is found that the sulfonium centers, rather than the sequence of peptide played an important role in immune activation. This discovery may provide a new paradigm for the rational design of peptide-based adjuvants. In brief, this study demonstrates that stapling peptides with sulfonium centers can provide a well-defined, programmable, biocompatible, and effective adjuvant for multiple types of vaccines.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2409567"},"PeriodicalIF":14.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Insights into the Substrate Recognition of Ginsenoside Glycosyltransferase Pq3-O-UGT2.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-29 DOI: 10.1002/advs.202413185

Qiushuang Ji, Yirong Liu, Huanyu Zhang, Yan Gao, Yixin Ding, Yuanyuan Ding, Jing Xie, Jianyu Zhang, Xinghua Jin, Bin Lai, Cheng Chen, Juan Wang, Wenyuan Gao, Kunrong Mei

{"title":"Structural Insights into the Substrate Recognition of Ginsenoside Glycosyltransferase Pq3-O-UGT2.","authors":"Qiushuang Ji, Yirong Liu, Huanyu Zhang, Yan Gao, Yixin Ding, Yuanyuan Ding, Jing Xie, Jianyu Zhang, Xinghua Jin, Bin Lai, Cheng Chen, Juan Wang, Wenyuan Gao, Kunrong Mei","doi":"10.1002/advs.202413185","DOIUrl":"https://doi.org/10.1002/advs.202413185","url":null,"abstract":"Ginsenosides are a group of tetracyclic triterpenoids with promising health benefits, consisting of ginseng aglycone attached to various glycans. Pq3-O-UGT2, an important UDP-dependent glycosyltransferase (UGT), catalyzes the production of Ginsenoside Rg3 and Rd by extending the glycan chain of Ginsenoside Rh2 and F2, respectively, with higher selectivity for F2. However, the mechanism underlying its substrate recognition remains unclear. In this study, the crystal structures of Pq3-O-UGT2 in complex with its acceptor substrates are solved. The structures revealed a Nα5-oriented acceptor binding pocket in Pq3-O-UGT2, shaped by the unique conformation of the Nα5-Nα6 linker. Hydrophobic interactions play a pivotal role in the recognition of both Rh2 and F2, while hydrogen bonds specifically aid in F2 recognition due to its additional glucose moiety. The hydrophobic nature of the acceptor binding pocket also enables Pq3-O-UGT2 to recognize flavonoids. Overall, this study provides novel insights into the substrate recognition mechanisms of ginsenoside UGTs, advancing the understanding of their function and specificity.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413185"},"PeriodicalIF":14.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melamine-Copolymerization Strategy Engineered Fluorinated Polyimides for Membrane-Based Sour Natural Gas Separation.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-29 DOI: 10.1002/advs.202416109

Yi Ren, Patrick T Wright, Zhongyun Liu, Shijie Yang, Lu Lu, John Yang, Xuezhen Wang, Sheng Guo

{"title":"Melamine-Copolymerization Strategy Engineered Fluorinated Polyimides for Membrane-Based Sour Natural Gas Separation.","authors":"Yi Ren, Patrick T Wright, Zhongyun Liu, Shijie Yang, Lu Lu, John Yang, Xuezhen Wang, Sheng Guo","doi":"10.1002/advs.202416109","DOIUrl":"https://doi.org/10.1002/advs.202416109","url":null,"abstract":"Membrane-based gas separation provides an energy-efficient approach for the simultaneous CO2 and H2S removal from sour natural gas. The fluorinated polyimide (PI) membranes exhibited a promising balance between permeability and permselectivity for sour natural gas separation. To further improve the separation efficiency of fluorinated PI membranes, a melamine-copolymerization synthetic approach is devised that aims to incorporate melamine motifs with high sour gas affinity into the structure of the PI membranes. The fluorinated copolyimide membranes that are structurally engineered exhibited excellent solution-processability and enhanced sweet-mixed gas selectivity compared to their original PI membranes. Additionally, under a five-component sour mixed-gas feed, these melamine-copolymerized fluorinated PI membranes provided superior combined H2S and CO2 removal efficiency in comparison to conventional glassy polymer membranes. The melamine-copolymerization strategy provides an easily operable and generally effective approach to developing performance-enhancing PI membranes for sour natural gas separation.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2416109"},"PeriodicalIF":14.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beam Scanning with Ultra-Low Sidelobes and In-Band Ultra-Low Scattering Characteristics Empowered by Single Space-Time-Coding Radiation-Scattering Metasurface.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-29 DOI: 10.1002/advs.202413429

Lixin Jiang, Yongfeng Li, Hao Yang, Mingbao Yan, Jinming Jiang, Yunwei Zhang, Zhe Qin, Wanwan Yang, Hongya Chen, Yongqiang Pang, Zhihao Guo, Lin Zheng, Jiafu Wang, Shaobo Qu

{"title":"Beam Scanning with Ultra-Low Sidelobes and In-Band Ultra-Low Scattering Characteristics Empowered by Single Space-Time-Coding Radiation-Scattering Metasurface.","authors":"Lixin Jiang, Yongfeng Li, Hao Yang, Mingbao Yan, Jinming Jiang, Yunwei Zhang, Zhe Qin, Wanwan Yang, Hongya Chen, Yongqiang Pang, Zhihao Guo, Lin Zheng, Jiafu Wang, Shaobo Qu","doi":"10.1002/advs.202413429","DOIUrl":"https://doi.org/10.1002/advs.202413429","url":null,"abstract":"The integrated modulation of radiation and scattering provides an unprecedented opportunity to reduce the number of electromagnetic (EM) apertures in the platform while simultaneously enhancing communication and stealth performance. Nevertheless, achieving full-polarization, arbitrary amplitude, and phase modulation of radiation scattering remains a challenge. In this paper, a strategy that realizes space-time coding of radiation scattering within the same frequency band, which enables the simultaneous and independent modulation of amplitude and phase, is proposed. To address the limitations of the high sideband levels (SBLs) of conventional space-time-coding metasurfaces, a strategy comprising nonuniform modulation periods and stochastic coding is proposed. Consequently, beam scanning with ultra-low sidelobe levels (SLLs) and suppressed SBLs is achieved in the radiation mode (RM). In scattering mode (SM), in-band low scattering characteristics are achieved within the same operating frequency band as RM. A prototype of a space-time-coding radiation-scattering metasurface (STCRSM) is fabricated and the aforementioned functionalities are validated by measurements. Furthermore, the proposed strategy does not necessitate the utilization of optimization algorithms and exhibits low SLLs and low SBLs, which will make it flourish in RF stealth applications, such as covert communication systems.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413429"},"PeriodicalIF":14.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Electromechanical Response and Field-Induced Shape Memory Effect in Ferroelectric Ceramics.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-29 DOI: 10.1002/advs.202410580

Menglu Li, Weili Li, Wenping Cao, Nuo Xu, Wenqi Li, Weidong Fei

引用次数: 0

Micro-Scale Topography Triggers Dynamic 3D Nuclear Deformations.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202410052

Claire Leclech, Giulia Cardillo, Bettina Roellinger, Xingjian Zhang, Joni Frederick, Kamel Mamchaoui, Catherine Coirault, Abdul I Barakat

{"title":"Micro-Scale Topography Triggers Dynamic 3D Nuclear Deformations.","authors":"Claire Leclech, Giulia Cardillo, Bettina Roellinger, Xingjian Zhang, Joni Frederick, Kamel Mamchaoui, Catherine Coirault, Abdul I Barakat","doi":"10.1002/advs.202410052","DOIUrl":"https://doi.org/10.1002/advs.202410052","url":null,"abstract":"Navigating complex extracellular environments requires extensive deformation of cells and their nuclei. Most in vitro systems used to study nuclear deformations impose whole-cell confinement that mimics the physical crowding experienced by cells during 3D migration through tissues. Such systems, however, do not reproduce the types of nuclear deformations expected to occur in cells that line tissues such as endothelial or epithelial cells whose physical confinement stems principally from the topography of their underlying basement membrane. Here, it is shown that endothelial cells and myoblasts cultured on microgroove substrates that mimic the anisotropic topography of the basement membrane exhibit large-scale 3D nuclear deformations, with partial to complete nuclear penetration into the microgrooves. These deformations do not lead to significant DNA damage and are dynamic with nuclei cyclically entering and exiting the microgrooves. Atomic force microscopy measurements show that these deformation cycles are accompanied by transient changes in perinuclear stiffness. Interestingly, nuclear penetration into the grooves is driven principally by cell-substrate adhesion stresses, with a limited need for cytoskeleton-associated forces. Finally, it is demonstrated that myoblasts from laminopathy patients exhibit abnormal nuclear deformations on microgrooves, raising the possibility of using microgroove substrates as a novel functional diagnostic platform for pathologies that involve abnormal nuclear mechanics.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2410052"},"PeriodicalIF":14.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

(NH₄)₂Cd₂Cl₃F₃ and (NH₄)₂Cd₂Br₃F₃: The First Fluoride-Containing d¹⁰ Metal Mixed Halides Exhibiting Superior Ultraviolet Nonlinear Optical Properties.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202414503

Seunghun Choi, Yang Li, Yunseung Kuk, Kang Min Ok

{"title":"(NH4)2Cd2Cl3F3 and (NH4)2Cd2Br3F3: The First Fluoride-Containing d10 Metal Mixed Halides Exhibiting Superior Ultraviolet Nonlinear Optical Properties.","authors":"Seunghun Choi, Yang Li, Yunseung Kuk, Kang Min Ok","doi":"10.1002/advs.202414503","DOIUrl":"https://doi.org/10.1002/advs.202414503","url":null,"abstract":"In the search for new ultraviolet (UV) nonlinear optical (NLO) materials, two novel cadmium mixed halide compounds, (NH4)2Cd2Cl3F3 and (NH4)2Cd2Br3F3, are successfully synthesized via hydrothermal methods. These compounds crystallize in the noncentrosymmetric (NCS) space group, R32, and are composed of distorted octahedral [CdX3F3] (X═Cl or Br) units, which extend into a 3D framework. Remarkably, both compounds demonstrate strong second-harmonic generation (SHG) efficiencies-3.0 and 8.0 times that of KH2PO4 for the Cl- and Br-containing analogs, respectively-with phase-matching behavior observed. The SHG efficiency is attributed to the highly distorted coordination environment of the polarizable d10 Cd2+ ions, with (NH4)2Cd2Br3F3 benefiting further from Br's greater polarizability. Furthermore, these compounds exhibit wide bandgaps exceeding 4.2 eV, making them the first d10 metal mixed halide systems incorporating fluoride that are suitable for UV NLO applications. With UV absorption cut-off edges as short as 203 nm for (NH4)2Cd2Cl3F3 and 243 nm for (NH4)2Cd2Br3F3, these materials represent a significant advancement in the development of UV-transparent NLO materials. This study introduces a novel synthetic strategy for the design of d10 mixed halide systems with enhanced optical properties, offering promising candidates for future UV NLO technologies.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2414503"},"PeriodicalIF":14.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Characterization of an Aldol Condensation Synthase PheG for the Formation of Hispidin from Phellinus Igniarius.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202413192

Wanting Zhang, Ruliang Zheng, Weiling Geng, Xinyuan Wu, Xiaojuan Gao, Li Zhou, Zhenyu An, Cheng Liu, Zhijun Song, Hongyan Ji, Hao Yang, Xiuli Wu

{"title":"Functional Characterization of an Aldol Condensation Synthase PheG for the Formation of Hispidin from Phellinus Igniarius.","authors":"Wanting Zhang, Ruliang Zheng, Weiling Geng, Xinyuan Wu, Xiaojuan Gao, Li Zhou, Zhenyu An, Cheng Liu, Zhijun Song, Hongyan Ji, Hao Yang, Xiuli Wu","doi":"10.1002/advs.202413192","DOIUrl":"https://doi.org/10.1002/advs.202413192","url":null,"abstract":"Hispidin (1) is a polyphenolic compound with a wide range of pharmacological activities that is distributed in both plants and fungi. In addition to natural extraction, hispidin can be obtained by chemical or enzymatic synthesis. In this study, the identification and characterization of an undescribed enzyme, PheG, from Phellinus igniarius (P. igniarius), which catalyzes the construction of a key C─C bond in the enzymatic synthesis of hispidin are reported. It is demonstrated in vitro that PheG generates hispidin by catalyzing C─C bond formation in the aldol condensation reaction. Based on these results, a plausible pathway for hispidin biosynthesis is proposed by utilizing the primary triacetic acid lactone (TAL, 2) and 3,4-dihydroxybenzaldehyde (3). The mechanisms for the aldol condensation reaction of PheG are investigated using molecular dynamics (MD) simulations, molecular mechanics/generalized Born surface area (MM/GBSA) binding free energy calculations, density functional theory, and site-specific mutations. The locations of the key amino acid residues that catalyze the conversion of substrates 2 and 3 to hispidin at the active site of PheG-1 are identified. This study provides a new method for preparing hispidin with high efficiency and low cost.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413192"},"PeriodicalIF":14.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Microalgae-Based Biosystem to Enhance Irreversible Electroporation Immunotherapy in Hepatocellular Carcinoma.

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-01-28 DOI: 10.1002/advs.202409381

Cheng Zeng, Shiyuan Hua, Jiayu Zhou, Tangye Zeng, Jianke Chen, Lijian Su, Angfeng Jiang, Min Zhou, Zhe Tang

{"title":"Oral Microalgae-Based Biosystem to Enhance Irreversible Electroporation Immunotherapy in Hepatocellular Carcinoma.","authors":"Cheng Zeng, Shiyuan Hua, Jiayu Zhou, Tangye Zeng, Jianke Chen, Lijian Su, Angfeng Jiang, Min Zhou, Zhe Tang","doi":"10.1002/advs.202409381","DOIUrl":"https://doi.org/10.1002/advs.202409381","url":null,"abstract":"Irreversible electroporation (IRE) is a novel local tumor ablation technique that can potentially stimulate immune responses. However, IRE alone cannot effectively activate the immune system or prevent distant metastases. Therefore, this study utilized the biocompatibility of Chlorella vulgaris (C. vulgaris) and polydopamine (PDA) adhesive properties to encapsulate a PD-1 inhibitor (PI). The PDA coating protects the drug from degradation by stomach acid and enhances its intestinal absorption. This carrier demonstrates excellent in vivo drug release control and biodistribution, significantly increasing the oral bioavailability of PI. Combining IRE with this natural carrier significantly improves the therapeutic efficacy, which increases the local drug concentration and activates the immune system. This system demonstrates significantly improved therapeutic efficacy against local tumors compared with PI or IRE alone and significantly reduces PI-associated side effects. A convenient oral delivery system is developed using this readily available natural micro-carrier that not only improves the therapeutic effect of IRE but also mitigates its adverse effects, indicating significant potential for clinical applications. This discovery offers a new strategy for hepatocellular carcinoma treatment with the potential to improve patient outcomes.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2409381"},"PeriodicalIF":14.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0