Advanced Science最新文献_第7页

SLC25A4^high Hepatocytes Enhance Lifestyle Intervention Response in MASLD by Recruiting Eating Macrophages. slc25a4高水平肝细胞通过招募进食巨噬细胞增强MASLD生活方式干预反应

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-15 DOI: 10.1002/advs.78004

Yiting Qian, Linying Lai, Yu Zhang, Yan Meng, Ziping Song, Baoyuan Huang, Guisheng Song, Bo Sun, Wenzhuo Yang

{"title":"SLC25A4high Hepatocytes Enhance Lifestyle Intervention Response in MASLD by Recruiting Eating Macrophages.","authors":"Yiting Qian, Linying Lai, Yu Zhang, Yan Meng, Ziping Song, Baoyuan Huang, Guisheng Song, Bo Sun, Wenzhuo Yang","doi":"10.1002/advs.78004","DOIUrl":"10.1002/advs.78004","url":null,"abstract":"While lifestyle interventions (LSI) are the cornerstone of metabolic dysfunction-associated steatotic liver disease (MASLD) management, the molecular mechanisms driving the histological and metabolic regression in LSI-responsive patients remain unclear. C57BL/6N mice were hydrodynamically injected with Slc25a4 and Sleeping Beauty transposon. Single-cell RNA sequencing (scRNA-seq) profiled the hepatic immune landscape. Metabolomics and co-culture assays analyzed intercellular crosstalk. Responsive MASLD patients had high SLC25A4 expression, correlating with exercise-induced hepatic steatosis improvement. Slc25a4 overexpression augmented exercise effects. scRNA-seq identified a distinct population of Clec4f+Timd4+P2ry12+ macrophages, defined as lipid-eating macrophages, in livers of Slc25a4-overexpressing mice. Macrophage depletion reinstated hepatosteatosis in high-fat, high-fructose, and high-cholesterol diet-fed exercised mice with Slc25a4 overexpression. Mechanistically, SLC25A4 mediates mitochondrial ATP exchange and selective ATP efflux. Ectopically overexpressed Slc25a4 activates Pannexin 1 to release ATP, which recruits eating macrophages via P2ry12, clearing lipid-laden hepatocytes. The GDF15-PPARα axis between macrophages and hepatocytes was activated. Macrophage Gdf15 knockdown abrogated Slc25a4-mediated enhanced hepatic fatty acid oxidation (FAO), and hepatic PPARα knockdown abolished this effect as well. Slc25a4 orchestrates an LSI-responsive hepatocyte-macrophage axis: Pannexin 1-mediated ATP release recruits lipid-eating macrophages, whose GDF15 activates PPARα-driven FAO, establishing Slc25a4 as a therapeutic target to restore exercise response in MASLD.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78004"},"PeriodicalIF":14.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved Skills for Predicting Sub-Seasonal to Seasonal Global Sea Surface Temperature. 预测亚季节到季节性全球海面温度的改进技术。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-15 DOI: 10.1002/advs.78271

Longhao Wang, Xuanze Zhang, Ruby L Leung, Francis H S Chiew, Amir AghaKouchak, Kairan Ying, Yongqiang Zhang

{"title":"Improved Skills for Predicting Sub-Seasonal to Seasonal Global Sea Surface Temperature.","authors":"Longhao Wang, Xuanze Zhang, Ruby L Leung, Francis H S Chiew, Amir AghaKouchak, Kairan Ying, Yongqiang Zhang","doi":"10.1002/advs.78271","DOIUrl":"10.1002/advs.78271","url":null,"abstract":"Accurate prediction of global sea surface temperature at sub-seasonal to seasonal (S2S) timescales is critical for drought and flood forecasting, as well as for improving disaster preparedness in human society. Operational physics-based numerical models are run to predict S2S sea surface temperature and corresponding climate indices, such as El Niño-Southern Oscillation. However, these models are hampered by computational inefficiencies, rapidly dissipating ocean-atmosphere initial conditions, and significant uncertainty and biases. Here, we introduce a novel spatiotemporal deep learning neural network to model the nonlinear and complex coupled atmosphere-ocean weather systems. This model, named as CAS-Canglong, incorporates climatic and temporal features and employs a self-attention mechanism to enhance the prediction of global S2S sea surface temperature pattern. Compared to the physics-based models, it shows higher computational efficiency and more predictive capability, improving one to three months sea surface temperature predictive skill by 55.6 ± 14.1% to 63.4 ± 15.5% in six ocean regions with dominant influence on S2S variability over land. This achievement underscores the huge potential of deep learning for largely improving forecasting skills at the S2S timescales over land.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78271"},"PeriodicalIF":14.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atlas-Guided CD55-Enriched Neutrophil Extracellular Vesicles for Complement-Macrophage Modulation in Diabetic Wounds. atlas引导的cd55富集中性粒细胞胞外泡对糖尿病伤口补体-巨噬细胞调节的影响。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-15 DOI: 10.1002/advs.78320

Tairong Cui, Jieying Li, Jibing He, Jia Wang, Yun Qian, Yilin Jin, Liuqing Yang, Zaijin Tao, Ziyun Li, Zhengsheng Chen, Wenjing Wang, Xin Ma, Jinglei Wu

{"title":"Atlas-Guided CD55-Enriched Neutrophil Extracellular Vesicles for Complement-Macrophage Modulation in Diabetic Wounds.","authors":"Tairong Cui, Jieying Li, Jibing He, Jia Wang, Yun Qian, Yilin Jin, Liuqing Yang, Zaijin Tao, Ziyun Li, Zhengsheng Chen, Wenjing Wang, Xin Ma, Jinglei Wu","doi":"10.1002/advs.78320","DOIUrl":"10.1002/advs.78320","url":null,"abstract":"Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single-cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic-wound single-cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of differentiation 55 (CD55) with complement-regulatory and reparative features. Guided by this atlas-derived signature, activated neutrophil-derived extracellular vesicles (aNEVs) enriched in CD55 are generated under high-glucose and lipopolysaccharide stimulation and incorporated into a microbial transglutaminase-crosslinked gelatin hydrogel for localized delivery and protease-sensitive matrix remodeling. The resulting gelatin/aNEV composite hydrogel (Gel/aNEV) attenuates complement-associated inflammatory signaling, C3a production, oxidative stress, and pro-inflammatory cytokine expression, while promoting reparative macrophage reprogramming and endothelial migration. In diabetic wounds, a single application of Gel/aNEV accelerates wound closure and enhances angiogenesis, collagen remodeling, and tissue regeneration. Integrated transcriptomic-proteomic analyses further reveal coordinated changes in complement, inflammatory, redox, extracellular-matrix, and regenerative programs, supporting a multicomponent therapeutic model. Collectively, this study establishes an atlas-to-therapy framework that uses disease-associated neutrophil states to guide extracellular-vesicle engineering, integrating complement regulation, immune reprogramming, and biomaterial-assisted delivery for diabetic wound repair.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78320"},"PeriodicalIF":14.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly-Time-Resolved Measurements of Tryptophan's Distribution and Homeostatic Regulation in Live, Intact Animals. 活体完整动物中色氨酸分布和稳态调节的高时间分辨测量。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-15 DOI: 10.1002/advs.77595

Yuyang Wu, Chelsea N Brown, Zeki Duman, Rose Mery Bakestani, Carl M Kirkpatrick, Joao Hespanha, Tod Kippin, Kevin W Plaxco

{"title":"Highly-Time-Resolved Measurements of Tryptophan's Distribution and Homeostatic Regulation in Live, Intact Animals.","authors":"Yuyang Wu, Chelsea N Brown, Zeki Duman, Rose Mery Bakestani, Carl M Kirkpatrick, Joao Hespanha, Tod Kippin, Kevin W Plaxco","doi":"10.1002/advs.77595","DOIUrl":"10.1002/advs.77595","url":null,"abstract":"Current theories regarding tryptophan's homeostatic regulation, which are derived from in vitro, post-mortem, and cell-culture studies, lack any direct evidence supporting their occurrence in living subjects. In response, here we have used 20 s resolution, multi-hour plasma measurements to confirm, for the first time, that the cooperativity and tryptophan-induced stabilization of tryptophan 2,3-dioxygenase (TDO) seen in vitro and in cell culture hold in live, intact animals. For example, a model coupling these regulatory mechanisms with a constant tryptophan production rate from tissue reservoirs describes our in vivo measurements quantitatively, and provides high-precision estimates of tryptophan flux and tryptophan-induced TDO up-regulation in individual subjects. In bridging a longstanding gap between ex vivo, post-mortem, and cell culture investigations and the physiology of live, intact animals, an advance that had previously only been reported for glucose, our results highlight the transformative power of applying only-recently-available, seconds-resolved metabolite measurements to the study of metabolic regulation.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77595"},"PeriodicalIF":14.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stretchable h-BN/TPU Fibers for Passive-Active Dual-Mode Thermal Management and Wearable Haptic Interfaces. 无源-主动式双模热管理和可穿戴触觉接口的可拉伸h-BN/TPU纤维。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-15 DOI: 10.1002/advs.78162

Yiwei Zhou, Shanshan Long, Bo Chen, Maohua Li, Linhong Li, Yue Qin, Rongjie Yang, Hanxi Chen, Cheng-Te Lin, Yixiang Xu, Kean How Cheah, Nan Jiang, Jinhong Yu

{"title":"Stretchable h-BN/TPU Fibers for Passive-Active Dual-Mode Thermal Management and Wearable Haptic Interfaces.","authors":"Yiwei Zhou, Shanshan Long, Bo Chen, Maohua Li, Linhong Li, Yue Qin, Rongjie Yang, Hanxi Chen, Cheng-Te Lin, Yixiang Xu, Kean How Cheah, Nan Jiang, Jinhong Yu","doi":"10.1002/advs.78162","DOIUrl":"10.1002/advs.78162","url":null,"abstract":"Wearable thermal interfaces require rapid, spatially confined thermal feedback together with mechanical compliance, yet existing passive thermal-management textiles and active thermal-haptic devices remain largely separate. Here, a stretchable h-BN/TPU composite fiber is developed by coupling microfluidic spinning with non-solvent-induced phase separation. Rectangular-channel confinement aligns hexagonal boron nitride plates within a microporous thermoplastic polyurethane matrix, constructing directional heat-conduction pathways while preserving large deformation. The optimized 30 wt.% h-BN/TPU fiber achieves a dry-state thermal conductivity of 2.08 and 4.14 W·m-1·K-1 under humid conditions, together with 9.67 MPa tensile strength and 422% elongation at break. Pareto-front analysis identifies the 30 wt.% composition as the thermal-mechanical knee, arising from the coupled effects of filler orientation, low void fraction, and deformable TPU domains. Woven h-BN/TPU fabrics provide passive thermal management, reducing surface temperature by 5.7°C under simulated solar irradiation and maintaining performance after 2000 bending cycles. When integrated into a thermal feedback glove, the fabric enables localized fingertip actuation with a heating rate of +29.55°C·s-1 and a thermal relaxation time of ∼20 s (returning below the warm perception threshold of 35°C). This fiber platform bridges passive heat regulation and active thermal haptics for next-generation thermally interactive wearables.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78162"},"PeriodicalIF":14.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlling Epitaxial Zn Growth via Guided Laser Patterning toward High-Performance 6Ah Aqueous Zn||I₂ Batteries. 利用激光导图技术控制高性能6Ah水锌bb| I2电池的外延锌生长。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-15 DOI: 10.1002/advs.78252

Suyeon Kim, Dongjae Kim, Youngeun Kim, Chaejeong Kim, Myunghyun Ryu, Wooyoung Jin, Hyeokjin Kwon, Kyu-Nam Jung, Ki Jae Kim, Jong-Won Lee, Jinhong Lee

{"title":"Controlling Epitaxial Zn Growth via Guided Laser Patterning toward High-Performance 6Ah Aqueous Zn||I2 Batteries.","authors":"Suyeon Kim, Dongjae Kim, Youngeun Kim, Chaejeong Kim, Myunghyun Ryu, Wooyoung Jin, Hyeokjin Kwon, Kyu-Nam Jung, Ki Jae Kim, Jong-Won Lee, Jinhong Lee","doi":"10.1002/advs.78252","DOIUrl":"10.1002/advs.78252","url":null,"abstract":"Aqueous zinc-ion batteries (AZIBs) are attractive for grid-scale energy storage because of their safety, low cost, and environmental benignity. However, their practical use is limited by interfacial instability at the Zn anode, which induces nonuniform Zn2+ flux, dendritic growth, and parasitic H2 evolution. Herein, we present a laser-induced surface patterning stategy that guides Zn epitaxial growth through a resistance-gradient-driven mechanism. Laser ablation forms periodic concave micro-holes, selectively removes the resistive carbonate-based surface layer from the exposed regions, and reconstructs the Zn texture from the (101) plane to the (002) basal plane. This surface-resistance contrast directs Zn2+ flux into the patterned holes, which serve as uniform nucleation sites and three-dimensional deposition reservoirs, enabling bottom-up Zn filling and compact homogeneous surface growth. Consequently, the patterned Zn||Zn symmetric cells achieve an exceptional lifespan of 972 cycles under high-rate conditions (10 mA cm-2, 2 mAh cm-2). Furthermore, a 6.5 Ah Zn||I2 pouch cell operating at 2C (10 × 18 cm2, areal capacity of 3.0 mAh cm-2) and employing the laser-patterned Zn anode exhibits stable cycling for over 440 cycles, a Coulombic efficiency of 99.9%, and a capacity retention of 90.7%.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78252"},"PeriodicalIF":14.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biobased Boston Ivy-Inspired Cryogel Integrating Radiative Cooling and Phase Change Energy Storage for Adaptive Thermal Regulation. 生物基波士顿常青藤冷冻凝胶集成辐射冷却和相变储能自适应热调节。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-15 DOI: 10.1002/advs.78323

Sining Huang, Zhiguo Li, Yang Liu, Chengyu Wang, Yi Lu, Erlantz Lizundia, Siqi Huan

{"title":"Biobased Boston Ivy-Inspired Cryogel Integrating Radiative Cooling and Phase Change Energy Storage for Adaptive Thermal Regulation.","authors":"Sining Huang, Zhiguo Li, Yang Liu, Chengyu Wang, Yi Lu, Erlantz Lizundia, Siqi Huan","doi":"10.1002/advs.78323","DOIUrl":"10.1002/advs.78323","url":null,"abstract":"Boston ivy is a traditional plant for building heat management through shading and transpiration. Inspired by its \"vine-leaf\" system, we design a bionic cryogel that functionalizes daytime cooling and nighttime thermal buffering, promoting sustainable and comfortable housing and living environments. The aligned channels mimic vine tendrils, delivering an ultralow radial thermal conductivity (0.035 W m-1·K-1), high solar reflectance (95.28%), and high infrared emissivity (97.04%). Embedded phase-change materials (PCMs) present leaf-like, functionalized structures that store excess solar energy during the daytime and release latent heat at night, achieving 6.2°C sub-ambient cooling under sunlight. In darkness, the stored latent heat is released, keeping the cryogel 2.4°C above ambient and preventing nocturnal overcooling. This spatiotemporal synergy between daytime radiative cooling and nighttime heat release enables climate-adaptive thermal management, reducing the urban heat buildup with no need for electricity consumption. Our bionic design shifts thermal regulation from passive adaptation to active thermal planning using low carbon footprint materials as proven by life cycle assessment (LCA), offering a more sustainable pathway for energy-efficient buildings.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78323"},"PeriodicalIF":14.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward Sustainable Separation and Recovery of Critical Metals From Discarded Industrial Perovskite Solar Modules. 从废弃的工业钙钛矿太阳能组件中可持续分离和回收关键金属。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-15 DOI: 10.1002/advs.78351

Guang Hu, Zhaoyang Li, Shifa Zhou, Jie Qin, Sha Liang, Huabo Duan, Liang Huang, Jingping Hu, Huijie Hou, Hongjie Zhou, Ling Xu, Chao Chen, Jiang Tang, Jiakuan Yang

{"title":"Toward Sustainable Separation and Recovery of Critical Metals From Discarded Industrial Perovskite Solar Modules.","authors":"Guang Hu, Zhaoyang Li, Shifa Zhou, Jie Qin, Sha Liang, Huabo Duan, Liang Huang, Jingping Hu, Huijie Hou, Hongjie Zhou, Ling Xu, Chao Chen, Jiang Tang, Jiakuan Yang","doi":"10.1002/advs.78351","DOIUrl":"10.1002/advs.78351","url":null,"abstract":"The rapid deployment of perovskite solar modules (PSMs) raises an urgent need for recycling strategies that can selectively recover critical metals from their complex multilayer architectures. Here, an architecture-guided sequential recycling strategy is developed by coupling interfacial accessibility with calcination-induced phase transformation. Ultrasonic water leaching removes >99.8% of Pb from the perovskite layer without detectable dissolution of other target metals. During subsequent HCl leaching, the polymer encapsulant functions as a physical barrier, enabling >99.9% In leaching while protecting the Sn-coated Cu ribbon from acid attack. Air calcination then removes the encapsulant and promotes the formation of CuO and chemically stable SnO2, creating a strong contrast in leaching behavior that enables selective Cu dissolution in an acetic acid-hydrogen peroxide system. Overall, recovery ratios of In and Cu exceed 99.7% and 96.1%, respectively, while most of the initial Sn is retained in a Sn-rich residue. The process further achieves a net economic benefit of about 4.735 USD/m2 module, demonstrating an economically promising and architecture-enabled route for selective multi-metal recovery from discarded industrial PSMs.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78351"},"PeriodicalIF":14.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative Approach Reveals How Receptors Control G Protein State Equilibria. 创新方法揭示受体如何控制G蛋白状态平衡。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-15 DOI: 10.1002/advs.77969

Alexandre Bouyssou, Mélanie Da Silva, Julien Soulé, Ludovic Fabre, Laurent Lamarque, Rémy Sounier, Thierry Durroux, Sébastien Granier, Thomas Roux, Elodie Dupuis, Eric Trinquet, Philippe Rondard, Jean-Philippe Pin

{"title":"Innovative Approach Reveals How Receptors Control G Protein State Equilibria.","authors":"Alexandre Bouyssou, Mélanie Da Silva, Julien Soulé, Ludovic Fabre, Laurent Lamarque, Rémy Sounier, Thierry Durroux, Sébastien Granier, Thomas Roux, Elodie Dupuis, Eric Trinquet, Philippe Rondard, Jean-Philippe Pin","doi":"10.1002/advs.77969","DOIUrl":"10.1002/advs.77969","url":null,"abstract":"G protein-coupled receptors (GPCRs) constitute the largest family of drug targets, acting through heterotrimeric G proteins. Agonist bound GPCRs promote GDP release from G proteins allowing their activation upon GTP binding. Here, we analyze this process with innovative tools that detect the main states of native Gi proteins: the GDP-bound, the open nucleotide-free and the active GTP-bound states. We show that receptor activation increases the amount of open-state Gi proteins, consistent with GDP release from inactive Gi proteins. We also observe that the active receptor can release GTP from the active Gi protein, to return to an inactive open state. Consistently, receptor activation also promotes the formation of the Gαβγ complex from the GTP-bound state in cells, in agreement with the formation of the receptor-G protein ternary complex. These data suggest that the amount of active GTP-bound form produced upon GPCR activation can be controlled by the receptor-induced GTP release. This control of G protein state equilibrium that depends on the receptor subtype may affect coupling efficacy. These data reveal receptor-dependent G-protein state equilibria and identify GTP release as an additional, context-dependent control point that can shape apparent coupling efficacy.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77969"},"PeriodicalIF":14.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interfacial Reconstruction Enables Enhanced Thermoelectric Performance in Bismuth Telluride-Based Alloys. 界面重建增强了碲化铋基合金的热电性能。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-15 DOI: 10.1002/advs.78266

Wenyi Chen, Xiao-Lei Shi, Meng Li, Chao Zhang, Konstantin Faershteyn, Siqi Liu, Yongqi Chen, Chengjiong He, Wanyu Lyu, Jun Pei, Nanhai Li, Zhi-Gang Chen

{"title":"Interfacial Reconstruction Enables Enhanced Thermoelectric Performance in Bismuth Telluride-Based Alloys.","authors":"Wenyi Chen, Xiao-Lei Shi, Meng Li, Chao Zhang, Konstantin Faershteyn, Siqi Liu, Yongqi Chen, Chengjiong He, Wanyu Lyu, Jun Pei, Nanhai Li, Zhi-Gang Chen","doi":"10.1002/advs.78266","DOIUrl":"10.1002/advs.78266","url":null,"abstract":"Bismuth telluride-based alloys are the benchmark thermoelectric materials for near-room-temperature power generation and solid-state cooling, yet further performance improvements through conventional optimization strategies remain challenging. Here, we introduce an interfacial reconstruction strategy by incorporating SnSe into Bi0.4Sb1.6Te3. Interdiffusion and chemical reconstruction at the Bi0.4Sb1.6Te3/SnSe heterointerfaces synergistically regulate charge-carrier transport and phonon scattering. As a result, the optimized composite achieves a peak dimensionless figure of merit (ZT) of ∼1.38 at 363 K and an average ZT of ∼1.25 across 303-423 K. Moreover, a single-leg thermoelectric device fabricated from this material delivers an energy conversion efficiency of ∼6.47% under a temperature difference of 200 K. These results establish interfacial reconstruction as a simple and effective approach to improving the thermoelectric performance of bismuth telluride-based alloys.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78266"},"PeriodicalIF":14.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0