Advanced Science最新文献_第3页

Surface Coordination-Dependent Oxygen Evolution Pathways in Rutile IrO₂. 金红石IrO2表面配位依赖的析氧途径。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-05 DOI: 10.1002/advs.78589

Gahee Noh, Seong-Sik Kim, Hyungwoo Lee, Jaejin Hwang, Michael Patton, Owen Ericksen, Tae Gyu Yun, Seung-Hyun Heo, Suho Lee, Yurim Hong, In Su Lee, Daesu Lee, Chang-Beom Eom, Jaekwang Lee, Minseok Choi, Sung-Yoon Chung, Si-Young Choi

{"title":"Surface Coordination-Dependent Oxygen Evolution Pathways in Rutile IrO2.","authors":"Gahee Noh, Seong-Sik Kim, Hyungwoo Lee, Jaejin Hwang, Michael Patton, Owen Ericksen, Tae Gyu Yun, Seung-Hyun Heo, Suho Lee, Yurim Hong, In Su Lee, Daesu Lee, Chang-Beom Eom, Jaekwang Lee, Minseok Choi, Sung-Yoon Chung, Si-Young Choi","doi":"10.1002/advs.78589","DOIUrl":"10.1002/advs.78589","url":null,"abstract":"Rutile iridium dioxide (IrO2) is renowned as an effective catalyst for the oxygen evolution reaction (OER), yet how its atomic structure governs orientation-dependent activity remains unclear. Here, we investigate epitaxial rutile IrO2 thin films with crystallographically well-defined (110), (101), and (001) orientations and show that their OER activity follows the order: (110) > (101) > (001). Atomic-resolution scanning transmission electron microscopy (STEM) analysis identifies distinct surface terminations and Ir-O coordination motifs that differ from commonly assumed idealized surface models. Experimentally informed electronic-structure calculations reveal that the (110) and (101) surfaces exhibit enhanced O 2p states near the Fermi level, favoring oxygen-involved charge transfer, whereas the (001) surface shows a more Ir-centered electronic character. Reaction-barrier calculations further indicate an energetic preference for the quadruple oxygen coupling mechanism (QOCM) on the (110) and (101) surfaces, whereas the (001) surface is more consistent with an Ir-centered adsorbate evolution mechanism (AEM)-like pathway. These results establish surface coordination as a key descriptor linking atomic termination, electronic structure, reaction pathway, and OER activity, providing a basis for designing high-performance IrO2 catalysts through surface-structure engineering.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13735428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular MRI Reveals Macrophage-Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer. 分子MRI显示肝癌不完全消融后肿瘤周围巨噬细胞富集的免疫重构。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-05 DOI: 10.1002/advs.78490

Yubei He, Han Xu, Julian M M Rogasch, Nikolaus Berndt, Jing Guo, Eyk Schellenberger, Akvile Häckel, Luisa Heidemann, Friederike Hesse, Yu Liu, Justus Ramtke, Nicola Beindorff, Frank Hofheinz, Avan Kader, Michael Mülleder, Kathrin Textoris-Taube, Bernd Hamm, Dominik N Müller, Robin Schmidt, Ralf Hauptmann, Heike Traub, Mathias Schannor, Lynn Jeanette Savic

{"title":"Molecular MRI Reveals Macrophage-Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer.","authors":"Yubei He, Han Xu, Julian M M Rogasch, Nikolaus Berndt, Jing Guo, Eyk Schellenberger, Akvile Häckel, Luisa Heidemann, Friederike Hesse, Yu Liu, Justus Ramtke, Nicola Beindorff, Frank Hofheinz, Avan Kader, Michael Mülleder, Kathrin Textoris-Taube, Bernd Hamm, Dominik N Müller, Robin Schmidt, Ralf Hauptmann, Heike Traub, Mathias Schannor, Lynn Jeanette Savic","doi":"10.1002/advs.78490","DOIUrl":"10.1002/advs.78490","url":null,"abstract":"Incomplete image-guided ablation can promote local tumor progression by reshaping the residual tumor microenvironment toward immunosuppression, yet noninvasive biomarkers of this process remain limited. Here, a translational multiparametric PET/MRI strategy was developed to monitor macrophage-associated microenvironmental remodeling after incomplete microwave ablation (iMWA) in orthotopic VX2 liver tumors. Twenty-four tumor-bearing rabbits were assigned to untreated control, early post-iMWA (short-term), or late post-iMWA (long-term) groups and underwent clinical 3 T PET/MRI, including diffusion-weighted imaging, dynamic contrast-enhanced MRI, [1 8F]FDG PET, and T2-weighted MRI before and after administration of Eu-VSOP. Eu-VSOP-enhanced MRI revealed a hypointense peritumoral rim after iMWA, with the largest rim-to-liver signal decrease and rim thickness observed in the long-term group. Prussian blue staining and LA-ICP-ToF-MS demonstrated preferential iron and europium enrichment in macrophage-rich, CD206-associated peritumoral regions. Histology and proteomics further demonstrated increased CD206 and MMP-9 expression, extracellular matrix remodeling, immunosuppressive myeloid-associated changes, and metabolic reprogramming in viable residual tumors, accompanied by altered [1 8F]FDG uptake. Together, these findings indicate that incomplete ablation induces a temporally evolving, macrophage-rich immunosuppressive peritumoral niche and support the potential of Eu-VSOP-enhanced multiparametric PET/MRI for noninvasive monitoring of post-ablation microenvironmental remodeling.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13735433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amyloid-Guided Assembly of Magnetically Recyclable Enzymatic Nanofibers Toward Sustainable Biocatalysis. 淀粉样蛋白引导的磁性可回收酶纳米纤维的可持续生物催化组装。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-05 DOI: 10.1002/advs.78579

Shuangping Liu, Qilin Yang, Qian Zhang, Tiantian Liu, Xiao Han, Jian Mao

{"title":"Amyloid-Guided Assembly of Magnetically Recyclable Enzymatic Nanofibers Toward Sustainable Biocatalysis.","authors":"Shuangping Liu, Qilin Yang, Qian Zhang, Tiantian Liu, Xiao Han, Jian Mao","doi":"10.1002/advs.78579","DOIUrl":"10.1002/advs.78579","url":null,"abstract":"The rational construction of recyclable protein-based catalytic materials requires connecting molecular enzyme design with higher-order supramolecular organization and functional recovery interfaces. This study establishes a hierarchical design strategy that integrates fusion-enzyme engineering, amyloid-guided self-assembly, and magnetic immobilization. The primary amine oxidase DPAO4 and the flavin-containing amine oxidase DMAO7 were joined through flexible or rigid linkers, and the rigid (EAAAK)3 variant provided broad substrate coverage, greater tolerance to process-relevant stresses, and lower interdomain fluctuations in molecular dynamics simulations. N-terminal Sup351-61 or Ure21-80 domains promoted the formation of ThT-responsive fibrillar assembly, and the resulting enzymatic nanofibers were coupled to amino-functionalized Fe3O4@SiO2-NH2 nanoparticles. The composites enabled magnetic separation within 30 s, catalyzed the degradation of eight biogenic amines under acidic, thermal, saline, and ethanol-containing conditions, and retained an average of 53.2% of their initial activity after four recovery cycles. As proof-of-concept evaluation in complex matrices, selected systems removed up to 70.6% of total biogenic amines from fermented beverages and 69.7% from soy sauce. The distinct responses of the Sup35- and Ure2-based composites suggest an association between assembly-domain identity and catalytic performance in complex matrices. This work demonstrates a hierarchical design approach for recyclable protein-based catalytic materials and sustainable biocatalysis.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13735435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanically-Gated Stochastic Resonance for All-Optical Acoustic Sensing in Noisy Environments. 噪声环境下全光声传感的机械门控随机共振。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-05 DOI: 10.1002/advs.78634

Xuyu Zhang, Minzheng Sun, Cunzheng Fan, Shuolong Zhu, Qilin Hong, Pan Xu, Min Zhu, Zhengliang Hu, Yongchao Zou, Qizhen Sun

{"title":"Mechanically-Gated Stochastic Resonance for All-Optical Acoustic Sensing in Noisy Environments.","authors":"Xuyu Zhang, Minzheng Sun, Cunzheng Fan, Shuolong Zhu, Qilin Hong, Pan Xu, Min Zhu, Zhengliang Hu, Yongchao Zou, Qizhen Sun","doi":"10.1002/advs.78634","DOIUrl":"10.1002/advs.78634","url":null,"abstract":"Weak signal detection in harsh and noisy environments remains a critical challenge across diverse fields. Stochastic resonance (SR) offers a counterintuitive strategy by exploiting noise to enhance, rather than suppress, weak signals, yet its practical deployment is severely limited by poor frequency selectivity, inadequate adaptability to fluctuating noise levels, and reliance on offline post-processing. Here we report the discovery and experimental demonstration of mechanically-gated stochastic resonance (MGSR), a novel physical mechanism that couples stochastic resonance with intrinsic mechanical resonance. By using mechanical resonance to actively modulate the bistable potential, MGSR achieves targeted frequency-line selection, robust adaptation to variable noise conditions, and markedly improved signal-to-noise ratio (SNR) gain for weak signal detection. We further realize a real-time, electromagnetic-interference-immune all-optical bistable system through a fiber Bragg grating feedback mechanism, enabling hardware-level MGSR free of computational latency. In tests conducted under realistic ocean ambient noise, our system attains a substantial SNR gain of 19.26 dB at the designed frequency, representing a clear advance for hardware-based stochastic resonance acoustic sensors. This work deepens the understanding of SR, establishes a robust all-optical architecture, and opens a scalable pathway toward high-performance, noise-resilient acoustic and vibration sensing for environmental monitoring, structural health diagnosis, and underwater safety.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13735441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CKMT1 Counteracts VDAC1 Oligomerization-Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke. CKMT1通过空间位阻抵消缺血性卒中中VDAC1寡聚化诱导的神经元焦亡。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-05 DOI: 10.1002/advs.78611

Xiaoyu Wang, Sai Shi, Jianghui Wu, Jingge Zhang, Shuqin Li, Yuyan Hu, Haifeng Yin, Chenguang Zhao, Dong Ma, Xiaohui Xian, Lizhe Liu, Ling Zhao, Xiyun Liu, Zhikai Yu, Lihua Dong, Wenbin Li, Lingyan Zhang, Min Zhang

{"title":"CKMT1 Counteracts VDAC1 Oligomerization-Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke.","authors":"Xiaoyu Wang, Sai Shi, Jianghui Wu, Jingge Zhang, Shuqin Li, Yuyan Hu, Haifeng Yin, Chenguang Zhao, Dong Ma, Xiaohui Xian, Lizhe Liu, Ling Zhao, Xiyun Liu, Zhikai Yu, Lihua Dong, Wenbin Li, Lingyan Zhang, Min Zhang","doi":"10.1002/advs.78611","DOIUrl":"10.1002/advs.78611","url":null,"abstract":"Ischemic stroke is one of the leading causes of death and disability worldwide; yet effective therapeutic options remain limited. Cytosolic leakage of mitochondrial DNA (mtDNA) is a critical driver of ischemic brain injury. Voltage-dependent anion channel 1 (VDAC1), embedded in the mitochondrial outer membrane, promotes mtDNA leakage through oligomerization. However, the regulatory mechanisms underlying VDAC1 oligomerization in ischemic stroke remain poorly understood. This study demonstrates that ischemic stroke promotes VDAC1 oligomerization, leading to mtDNA leakage, activating the absent in melanoma 2 (AIM2) inflammasome, and subsequent neuronal pyroptosis. Pharmacological inhibition of VDAC1 oligomerization using VBIT-4 effectively disrupts this cascade. Creatine kinase mitochondrial 1 (CKMT1) is identified as a novel endogenous inhibitor of VDAC1 oligomerization. CKMT1 inhibits VDAC1 oligomerization through a dual-region synergistic mechanism. Specifically, the N-terminal domain of CKMT1 (residues R75 and E121) forms a stable interface with the C-terminal domain of VDAC1 (residues R218 and E189), whereas the CKMT1 signal peptide (residues 1-39) sterically hinders VDAC1 dimerization, thereby blocking oligomerization. Moreover, neuronal overexpression of CKMT1 significantly attenuates neuronal apoptosis, whereas CKMT1 knockdown aggravates neuronal injury. Collectively, these findings demonstrate that CKMT1 protects against cerebral ischemic injury by suppressing the VDAC1-mtDNA-AIM2 axis and identify CKMT1 as a novel therapeutic target for ischemic stroke.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13735431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piezoelectric Amino Acid Salts with Halogen-Based Coformers Produce Exceptional Force-Generated Voltage Output. 具有卤素基共形的压电氨基酸盐产生特殊的力产生的电压输出。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-05 DOI: 10.1002/advs.78588

Krishna Hari, Shubham Vishnoi, Sarah Guerin

{"title":"Piezoelectric Amino Acid Salts with Halogen-Based Coformers Produce Exceptional Force-Generated Voltage Output.","authors":"Krishna Hari, Shubham Vishnoi, Sarah Guerin","doi":"10.1002/advs.78588","DOIUrl":"10.1002/advs.78588","url":null,"abstract":"Hierarchical self-assemblies of bio-inspired materials combine structural tunability with biocompatibility and environmental sustainability for multifunctional applications. Within this area of applied research, minimalistic building units such as amino acids and their derivatives have evolved as next-generation piezoelectric materials. Their tendency towards chiral nature, polar molecular structure, asymmetric crystal packing, and designability enable efficient linear voltage generation under mechanical stress, yet their technological translation is at formative stages. Amino acid-based multicomponent crystals (MCCs) are an emerging class of sustainable piezoelectrics, which benefit from an integrated experimental-theoretical approach for commercial advancement. In this work, the piezoelectric properties of nine non-centrosymmetric amino acid salt crystals were confirmed experimentally using both piezoresponse force microscopy (PFM) and quasi-static piezoelectric measurements (d33 = 7.8 pC/N) and calculated using density functional theory (DFT), with a maximum predicted longitudinal piezoelectric coefficient of 7.5 pC/N. A large open-circuit voltage of 12.9 V was obtained for polycrystalline L-histidinium trifluoroacetate under direct ambient mechanical stimuli, exceeding the open-circuit voltage of ~6 V of a commercial ceramic disc. The close agreement between measured and computed electromechanical properties allows for correlations to be drawn between the MCC molecular structures and their macroscopic properties, facilitating the rational design of sustainable organic piezoelectrics.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13735429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Learning for AD Risk Screening and Progression Prediction. 深度学习用于AD风险筛选和进展预测。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-05 DOI: 10.1002/advs.78537

Bin Lu, Yan-Rong Chen, Rui-Xian Li, Ming-Kai Zhang, Shao-Zhen Yan, Guan-Qun Chen, Jing-Hua Wang, Wen-Hui Chai, Francisco Xavier Castellanos, Paul M Thompson, Jie Lu, Ying Han, Chao-Gan Yan

{"title":"Deep Learning for AD Risk Screening and Progression Prediction.","authors":"Bin Lu, Yan-Rong Chen, Rui-Xian Li, Ming-Kai Zhang, Shao-Zhen Yan, Guan-Qun Chen, Jing-Hua Wang, Wen-Hui Chai, Francisco Xavier Castellanos, Paul M Thompson, Jie Lu, Ying Han, Chao-Gan Yan","doi":"10.1002/advs.78537","DOIUrl":"10.1002/advs.78537","url":null,"abstract":"The rise of Alzheimer's disease (AD) immunotherapies underscores the need for accessible, time-efficient biomarkers for early diagnosis. MRI-based deep learning shows promise in this regard, yet few models have undergone comprehensive clinical validation. Using the SILCODE cohort (722 Chinese participants, 1,105 scans), we test the transportability of our classifier (pretrained on Western samples) to an independent Chinese cohort without retraining. The associations between risk scores and disease progression, cognitive performance, and plasma biomarkers are examined. In addition, an interpretable framework is developed to generate individualized brain risk maps and identify subtypes. The model classifies AD with an AUC of 0.913 and 95.2% sensitivity, identifying 90.5% of high-risk individuals 2-3 years before clinical diagnosis. Risk scores correlate significantly with cognitive and plasma indices, particularly p-tau 217. Brain risk maps reveal AD subtypes, including a subgroup with rapid cognitive decline. These findings establish a population-robust, clinically relevant MRI-based model for early AD detection and risk stratification.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13735437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Novel Viral Non-Coding RNA LMP2A-IT1 Promotes the Lytic Replication of EBV. 新型病毒非编码RNA LMP2A-IT1促进EBV的裂解复制。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-05 DOI: 10.1002/advs.78488

Zheng-Zhou Lu, Jun-Fei Wu, Nannan Zhu, Ming-Hui Yang, Le-Le Zhang, Yuan-Tao Liu, Wei-Jun Chen, Jin-Kun Tang, Jia-Wei Ge, Chao-Bo Lei, Tao Zhang, Yu Wang, Chao-Yun Huang, Qian Zhong, Mu-Sheng Zeng, Yan Li

{"title":"The Novel Viral Non-Coding RNA LMP2A-IT1 Promotes the Lytic Replication of EBV.","authors":"Zheng-Zhou Lu, Jun-Fei Wu, Nannan Zhu, Ming-Hui Yang, Le-Le Zhang, Yuan-Tao Liu, Wei-Jun Chen, Jin-Kun Tang, Jia-Wei Ge, Chao-Bo Lei, Tao Zhang, Yu Wang, Chao-Yun Huang, Qian Zhong, Mu-Sheng Zeng, Yan Li","doi":"10.1002/advs.78488","DOIUrl":"10.1002/advs.78488","url":null,"abstract":"The Epstein-Barr virus (EBV) is recognized as the first human tumor virus and etiologically linked to a spectrum of malignancies and autoimmune diseases. EBV lytic replication contributes substantially to pathogenesis, but the viral components that enable efficient replication within host cells remain incompletely understood. Here, we identified a previously unknown EBV non-coding RNA (ncRNA) from glycoRNA samples and designated it LMP2A-IT1. This viral ncRNA was consistently detected across multiple EBV-infected cell lines, in exosomes, and in EBV-positive nasopharyngeal carcinoma tissues, exhibiting a predominantly cytoplasmic distribution. Functional analyses reveal that the induction of LMP2A-IT1 during EBV lytic replication actively drives the lytic cycle, resulting in a self-amplifying positive feedback loop. Mechanistically, LMP2A-IT1 appears to activate an inflammatory response, which subsequently upregulates BZLF1, a master regulator of the EBV lytic cascade, to facilitate lytic progression. Together, our findings suggest that LMP2A-IT1 represents a previously unrecognized viral factor that EBV deploys to achieve robust replication. To our best knowledge, this is the first report of a viral RNA harboring glycosylation modifications, thereby expanding the glycoRNA landscape. Moreover, this study offers new mechanistic insights into EBV replication as well as a potential biomarker and therapeutic target for EBV-associated diseases.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13735861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strain-Enhanced Ultrastretchable Semiconducting Polymer Fibers for Organic Electrochemical Transistors. 用于有机电化学晶体管的应变增强超可拉伸半导体聚合物纤维。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-05 DOI: 10.1002/advs.78666

Zixu Chang, Ziao Xu, Qi Tang, Mingjuan Du, Faqiang Wang, Jiexun Zhu, Jianyong Yu, Bin Ding, Zhaoling Li

{"title":"Strain-Enhanced Ultrastretchable Semiconducting Polymer Fibers for Organic Electrochemical Transistors.","authors":"Zixu Chang, Ziao Xu, Qi Tang, Mingjuan Du, Faqiang Wang, Jiexun Zhu, Jianyong Yu, Bin Ding, Zhaoling Li","doi":"10.1002/advs.78666","DOIUrl":"10.1002/advs.78666","url":null,"abstract":"Wearable electronics and soft bioelectronics require stretchable devices with steady performance under deformation. However, the balance between electrical performance and stretchability remains a critical obstacle, and most approaches sacrifice charge transport mobility to achieve stretchability. Herein, we present a material design concept that utilizes a wet-spinning strategy to fabricate highly stretchable semiconducting polymer fibers, enabling high-performance organic electrochemical transistors (OECTs) with stable or even enhanced charge transport mobility under large strains. The polymer chains are ordered within the fibers under the shear effects of the spinning fluid and can reorient during stretching to dissipate strain energy, further forming a more compact and ordered molecular arrangement. As a result, the fabricated semiconductor fiber can be stretched to over 250% strain and exhibit an ultrahigh normalized transconductance of 276.4 S cm-1, far exceeding thin-film polymer semiconductors. More importantly, the fiber OECTs possess unique strain-enhanced electrical performance, with substantially improved charge carrier mobility after strain-induced ordered arrangement of molecular chains. The skin-like fully stretchable OECTs have been successfully applied for recording electrocardiogram signals. This work provides more possibilities for the further development of stretchable semiconducting polymer materials with high electrical performance.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13735436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-State-Driven Selectivity of Electrocatalytic Glucose Oxidation: Metallic Au, Au─OH, and CuO. 电催化葡萄糖氧化的表面态驱动选择性：金属Au、Au─OH和CuO。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-11-05 DOI: 10.1002/advs.78627

Myeonghwan Oh, Hoeun Seong, Ga Eun Jo, Jiyoung Hwang, Yurim Sohn, Kyoungsuk Jin, Jong Hyeok Park, Wooyul Kim, Seok Ki Kim, Dong Ki Lee

{"title":"Surface-State-Driven Selectivity of Electrocatalytic Glucose Oxidation: Metallic Au, Au─OH, and CuO.","authors":"Myeonghwan Oh, Hoeun Seong, Ga Eun Jo, Jiyoung Hwang, Yurim Sohn, Kyoungsuk Jin, Jong Hyeok Park, Wooyul Kim, Seok Ki Kim, Dong Ki Lee","doi":"10.1002/advs.78627","DOIUrl":"10.1002/advs.78627","url":null,"abstract":"The electrochemical glucose oxidation reaction (GLUOR) offers a sustainable route for biomass valorization, yet its reaction mechanisms and the factors governing product selectivity remain poorly understood. Herein, we present a comprehensive mechanistic investigation of GLUOR on Au and CuO catalysts. Au catalysts preserve the C6 carbon backbone while exhibiting surface-state-dependent oxidation of terminal functional groups of glucose (GLU), whereas CuO catalysts preferentially promote C─C bond cleavage reactions. Theoretical investigation reveals that C─C bond cleavage is energetically unfavorable on Au surfaces, in either the metallic or the hydroxylated state, but it is thermodynamically preferred on CuO surfaces. Furthermore, we provide spectroscopic and computational evidence that pyranose glucose undergoes ring opening on metallic Au surfaces, while ring-retained pathways dominate on Au─OH and CuO surfaces, leading to gluconolactone formation and C─C bond cleavage, respectively. These findings provide a fundamental framework for interpreting product selectivity in glucose oxidation and offer mechanistic insights applicable to a broad range of biomass valorization processes.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13735442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0