Advanced Science最新文献

{"title":"Nickel Intercalation in Epitaxial Graphene on SiC(0001): A Novel Platform for Engineering Two-Dimensional Heterostructures.","authors":"Ylea Vlamidis, Stiven Forti, Antonio Rossi, Arrigo Calzolari, Carmela Marinelli, Camilla Coletti, Stefan Heun, Stefano Veronesi","doi":"10.1002/advs.77456","DOIUrl":"10.1002/advs.77456","url":null,"abstract":"<p><p>Two-dimensional (2D) magnetic materials integrated with graphene offer a compelling platform for next-generation spintronic devices. Yet nickel in its 2D form remains largely unexplored, due to fundamental synthesis limitations. Here, we report the controlled intercalation of Ni beneath epitaxial graphene on the Si-face of SiC(0001), achieved through a scalable colloidal nanoparticle deposition route. Chemically synthesized Ni nanoparticles ( <math><mo>∼</mo></math> 10 nm diameter) are uniformly deposited onto graphene via immersion in colloidal solution at room temperature; subsequent thermal annealing at 650 <math> <mrow><msup><mrow></mrow> <mo>∘</mo></msup> <mi>C</mi></mrow> </math> drives intercalation, yielding well-ordered Ni islands at the graphene/buffer-layer interface with morphology dictated by annealing conditions. Scanning tunneling microscopy (STM) and angle-resolved photoemission spectroscopy (ARPES), supported by density functional theory (DFT) calculations, elucidate the atomic and electronic structure of the intercalated layers. DFT simulations further confirm the thermodynamic stability of the 2D nanostructures as a function of shape and lateral size, predicting a robust average magnetic moment of 0.9 <math><msub><mi>μ</mi> <mi>B</mi></msub> </math> per atom. The resulting Ni-intercalated graphene on SiC constitutes a well-defined 2D heterostructure combining preserved graphene band structure with robust interfacial magnetism, stable under ambient conditions. These findings establish a reproducible, scalable pathway to engineer magnetic graphene-based heterostructures and open new avenues for their integration into spintronic architectures.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77456"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DyProL: Dynamic Ensemble Representation Learning for Protein-Nucleic Acid Binding Site Prediction.","authors":"Pengpai Li, Yiman Liu, Liya Liang, Rongming Liu","doi":"10.1002/advs.77501","DOIUrl":"10.1002/advs.77501","url":null,"abstract":"<p><p>Protein-nucleic acid interactions play central roles in gene regulation and cellular function, and extensive efforts have been devoted to predicting nucleic acid binding sites from protein structures. However, protein-nucleic acid recognition is inherently dynamic, whereas most existing computational approaches rely on single static conformations, limiting their ability to capture conformational heterogeneity underlying binding. Here, we present DyProL, an ensemble-based conformational representation learning framework that models proteins as ensembles of conformations sampled from equilibrium-like structural distributions. DyProL learns dynamic structural features through iterative aggregation of intra- and inter-conformation geometric information, enabling representation of both local structural context and global conformational variability. Across multiple benchmarks, DyProL consistently outperforms state-of-the-art methods in nucleic acid binding site prediction, with particularly pronounced improvements under realistic settings using predicted or apo-like structures, where static methods degrade substantially. These results establish dynamic ensemble-based representations as a general and scalable paradigm for structure-based protein modeling, providing a foundation for improving a broad range of protein function prediction tasks.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77501"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Hermitian Stealthy Hyperuniformity","authors":"Gitae Lee,&nbsp;Seungmok Youn,&nbsp;Ikbeom Lee,&nbsp;Kunwoo Park,&nbsp;Duhwan Hwang,&nbsp;Seungkyun Park,&nbsp;Xianji Piao,&nbsp;Namkyoo Park,&nbsp;Sunkyu Yu","doi":"10.1002/advs.77054","DOIUrl":"10.1002/advs.77054","url":null,"abstract":"<p>Symmetry-driven wave physics in open systems, exemplified by parity-time (PT) symmetry, has extended the landscape of crystalline phases in materials science to include gain-loss media. Given the growing interest in engineering disorder for wave manipulation, such non-Hermitian crystals motivate the extension of non-Hermitian frameworks into the realm of correlated disorder. Here, we propose hyperuniformity and stealthiness in non-Hermitian systems as a generalization of PT-symmetric crystals to correlated disorder in the weak-scattering limit. We extend the scattering-microstructure correspondence to open systems, formulating non-Hermitian hyperuniformity and stealthiness that encompass their Hermitian counterparts. This approach—incorporating a statistical crystallography framework for non-Hermitian materials—demonstrates that real-imaginary cross-correlations of the material potential are irrelevant for achieving hyperuniformity but essential for characterizing stealthiness, revealing unidirectional scattering phases that are inaccessible in both Hermitian materials and non-Hermitian crystals. Our non-Hermitian extension also reveals unique band coalescence in the strong scattering regime, suggesting stochastic exceptional-point dynamics. By analyzing the microstructural statistics of the resulting materials, our results—building on non-Hermitian wave physics—establish a connection to materials science, encompassing conventional descriptors of correlated disorder.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 49","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics-Based Optimization with Limited Activity Data.","authors":"Maximilian Krebs, Herre Jelger Risselada","doi":"10.1002/advs.76899","DOIUrl":"10.1002/advs.76899","url":null,"abstract":"<p><p>Membrane-targeting peptide motifs recognize characteristic features of biological membrane targets through specific interactions with their lipid composition. To elucidate the complex relationship between binding sequences and lipid composition, an alternative computational framework to leverage limited sequence activity data by combining genetic algorithms with coarse-grained molecular dynamics simulations is proposed. As demonstrated through evolutionary optimization of model membranes containing mammalian lipid compositions, four true-positive and four false-positive antimicrobial peptide sequences contain sufficient signal to tune membrane properties that maximize the separation in insertion behavior between true positives (deep insertion) and false positives (shallow insertion) in coarse-grained molecular dynamics simulations. This yields a robust discriminative performance comparable to that of large data-driven classification methods on the balanced, small dataset tested. This finding reveals how subtle differences in lipid composition precisely control the selective binding of membrane-associated proteins, thereby regulating their trafficking, aggregation, and function within living cells. The used methodology reconstructs lipidomic profiles from limited sequence data, uniquely revealing targeting patterns for therapeutic peptides and the selectivity mechanisms of membrane-associated proteins.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e76899"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer”","authors":"","doi":"10.1002/advs.76845","DOIUrl":"10.1002/advs.76845","url":null,"abstract":"<p>M. Tang, F. Zhou, Q. Sun, H. Shi, et al. “Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer,” <i>Adv</i><i>anced</i> <i>Sci</i><i>ence</i> 9 no. 29, (2022): 2201992, https://doi.org/10.1002/advs.202201992.</p><p>During the preparation of figures for the original publication, inappropriate cropping, resizing, and layout adjustment of Western blot images for Figure 4D,M led to visual similarities between partial bands of the two panels, which caused misunderstanding of the experimental data.</p><p>Figure 4D presents the basal expression of metabolic-related proteins in three colon cancer cell lines (HT29, SW620, SW480). Figure 4M validates the protein knockdown efficiency of OXCT1 in SW480 cells using two independent shRNA sequences (shRNA1, shRNA3) and a negative control (NC). These two panels correspond to distinct experimental samples. In the original laboratory workflow, the two groups of samples were loaded onto the same gel and detected simultaneously on one Western blot membrane to ensure consistent experimental conditions and reliable comparison of basal protein expression. When preparing the composite figure, improper horizontal and vertical resizing and cropping of the original full Western blot image resulted in overlapping visual features between the two panels.</p><p>To address the above issues thoroughly, the authors have completed two independent new replicate experiments for all assays shown in Figure 4M–Q, including repeated Western blot verification of OXCT1 knockdown efficiency and repeated detection of ketone body utilization capacity. All raw uncropped Western blot scans, original quantification data and detailed laboratory records of the new replicates are retained for verification.</p><p>The fully corrected Figure 4, with standardized cropping, complete panel labels and data from newly repeated experiments, is provided below as it should have appeared in the original publication. All core experimental results and scientific conclusions described in the original article are fully supported and reproducible by the new replicate data.</p><p></p><p>The authors apologize for these errors and for the inconvenience and confusion they may have caused to the journal, editors, reviewers, and readers.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 49","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13426091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148628887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-7R-Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation","authors":"Yao Liao,&nbsp;Yuheng Liu,&nbsp;Ruibing Yang,&nbsp;Zifeng Zhu,&nbsp;Junwei Wu,&nbsp;Dinghao Li,&nbsp;Jin Su,&nbsp;Yingxin He,&nbsp;Shiqi Luo,&nbsp;Feiyang Cao,&nbsp;Haiyi Deng,&nbsp;Lanmengxi Yang,&nbsp;Ling Zhong,&nbsp;Peiying Peng,&nbsp;Xinyi Wu,&nbsp;Chunmei Cai,&nbsp;Zhen Li,&nbsp;Yujin Wu,&nbsp;Shuofeng Zhu,&nbsp;Jie Wei,&nbsp;Yi Yang,&nbsp;Lifu Wang","doi":"10.1002/advs.202520331","DOIUrl":"10.1002/advs.202520331","url":null,"abstract":"<p>Mounting evidence highlights the involvement of extra-intestinal organs in inflammatory bowel disease (IBD) progression, yet the mechanisms underlying gut-extraintestinal organ crosstalk remain poorly understood. Extracellular vesicles (EVs) serve as pivotal mediators of inter-organ communication. Here, this study demonstrates that circulating EVs from colitis exacerbate colitis severity by inducing neutrophil extracellular trap (NET) formation. Inhibition of circulating EV secretion or NET formation alleviates colitis severity. Mechanistically, EVs enriched with interleukin-7 receptor (IL-7R) are identified as critical drivers of NET-mediated colitis exacerbation. Downregulation of IL-7R ameliorates colitis symptoms, whereas IL-7R upregulation worsens disease progression. IL-7R is found to induce NETs via the protein-arginine deiminase type 4 (PAD4) pathway to aggravate colitis. Furthermore, this study establishes that thymus-derived EVs are the primary source of IL-7R-enriched circulating EVs. During colitis, elevated circulating lipopolysaccharide (LPS) stimulates the thymus to release IL-7R-enriched EVs, which then migrate via the thymus-gut axis and promote NET formation in colonic tissues. This study reveals a previously unrecognized thymus-gut communication axis mediated by IL-7R-enriched EVs in IBD pathogenesis and provides an explanation for why IBD predominantly affects children and young adults. Targeting this axis may offer novel therapeutic strategies for IBD management.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 49","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13335758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orientation Engineering in Flexible Ag2Se-Based Thermoelectric Films","authors":"Hao Wu,&nbsp;Xiao-Lei Shi,&nbsp;Qingfeng Liu,&nbsp;Zhi-Gang Chen","doi":"10.1002/advs.76925","DOIUrl":"10.1002/advs.76925","url":null,"abstract":"<p>Flexible thermoelectrics convert body heat into electricity, offering a promising route towards self-powered wearable electronics while overcoming the limitations of conventional batteries. Among emerging flexible thermoelectric materials, silver selenide (Ag₂Se) has attracted widespread attention because it combines outstanding near-room-temperature thermoelectric performance with low cost, excellent mechanical flexibility, and superior biocompatibility. Over the past five years, orientation engineering has emerged as an effective strategy for simultaneously enhancing carrier transport and suppressing carrier scattering, leading to remarkable improvements in both material properties and device performance. In this Perspective, we systematically review recent progress in highly oriented Ag₂Se films, including deposited, nanowire-based, selenized, and free-standing architectures. We further propose film thickness together with near-room-temperature power factor as practical metrics for benchmarking their application potential. By correlating fabrication strategies, microstructural evolution, crystallographic orientation, and thermoelectric performance, we establish a unified framework for understanding orientation-dependent charge transport in Ag₂Se films. Finally, we discuss the remaining scientific and technological challenges and highlight future opportunities for developing scalable, mechanically robust, and high-performance Ag₂Se films for next-generation wearable thermoelectric energy harvesters and self-powered physiological monitoring systems.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 49","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13423508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148628943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multimodal Haptic Feedback Interface with Thin-Film Compliant Mechanism (Adv. Sci. 49/2026)","authors":"Jingjing Wan,&nbsp;Emanuele Nicotra,&nbsp;James Davies,&nbsp;Kefan Zhu,&nbsp;Quang Anh Nguyen,&nbsp;Sinuo Zhao,&nbsp;Chi Cong Nguyen,&nbsp;Bibhu Sharma,&nbsp;Adrienne Ji,&nbsp;Hermione Truong,&nbsp;Patrick Pruscino,&nbsp;Tan Huynh,&nbsp;Phuoc Thien Phan,&nbsp;Hoang-Phuong Phan,&nbsp;Nigel Hamilton Lovell,&nbsp;Thanh Nho Do","doi":"10.1002/advs.77256","DOIUrl":"https://doi.org/10.1002/advs.77256","url":null,"abstract":"<p><b>Electromagnetic Multimodal Haptic Device</b></p><p>In this work, Thanh Nho Do, Jingjing Wan, and co-workers have developed an electromagnetic multimodal haptic device capable of delivering indentation, stretch, and vibration stimuli to enrich tactile perception. The device incorporates a novel polymer thin-film compliant mechanism that enables high translational compliance along the X, Y, and Z axes while maintaining high rotational stiffness, supporting versatile and precise multimodal haptic feedback. More details can be found in the Research Article (DOI: 10.1002/advs.76412).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 49","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.77256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148871904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information: (Adv. Sci. 49/2026)","authors":"","doi":"10.1002/advs.77258","DOIUrl":"https://doi.org/10.1002/advs.77258","url":null,"abstract":"","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 49","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.77258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148871905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nrsn1-Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic-phase Recovery After Ischemic Stroke.","authors":"Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong","doi":"10.1002/advs.77547","DOIUrl":"10.1002/advs.77547","url":null,"abstract":"<p><p>Stroke remains a leading cause of long-term neurological disability worldwide, largely due to irreversible neuronal loss and the limited regenerative capacity of the adult mammalian brain. Neural stem cells (NSCs) in the adult brain possess the potential to generate new neurons after injury, yet the molecular mechanisms regulating their neuronal differentiation following ischemic insult remain incompletely understood. Here, integrating single-cell multi-omics analyses with spatial transcriptomics, we systematically delineated cell type-specific spatiotemporal dynamics in the striatum of a mouse model of ischemia-reperfusion injury. We identified Neurensin 1 (Nrsn1) as a gene markedly upregulated during NSC-derived neuronal differentiation in the recovery phase. Mechanistically, Foxa2 directly activates Nrsn1 transcription, whereas Nrsn1 promotes neuronal differentiation by facilitating the nuclear translocation of the chromatin-remodeling factor Smarcc1 in vitro. In vivo, both endogenous NSCs and transplanted NSCs overexpressing Nrsn1 significantly enhanced neuronal regeneration and improved functional recovery in mice subjected to middle cerebral artery occlusion and reperfusion (MCAO/R). Collectively, these findings identify Nrsn1 as a key regulator of NSC neuronal differentiation and uncover a Nrsn1-Smarcc1 coupling mechanism that promotes neural regeneration after ischemic brain injury, highlighting a potential molecular target for strategies aimed at enhancing post-stroke recovery.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77547"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}