Advanced Science最新文献_第3页

Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy 利用微生理系统促进以中性粒细胞为基础的癌症免疫治疗。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-19 Epub Date: 2026-09-13 DOI: 10.1002/advs.77572

Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones

{"title":"Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy","authors":"Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones","doi":"10.1002/advs.77572","DOIUrl":"10.1002/advs.77572","url":null,"abstract":"Neutrophils are the most abundant immune cells in human blood and serve as the first line of defense against infection. However, the role of neutrophils in cancer progression is complex and context-dependent, and they are underexplored as therapeutic targets for cancer compared with other immune cell types. Microphysiological systems, also known as complex in vitro models, have emerged as powerful tools for deciphering immune cell-cancer interactions and preclinical drug testing due to the advantages of real-time visualization of cell behaviors, precise control of microenvironments, and incorporation of human cells over in vivo animal models. This review first summarizes the multifaceted roles of neutrophils in cancer as defined by in vivo animal models and highlights recently developed strategies to mobilize neutrophils for cancer treatment. Next, current applications of different types of microphysiological systems, including 3D spheroids, organoids, and microfluidic organ-on-a-chip platforms, for investigating the role of human neutrophils in cancer and evaluating neutrophil-based cancer immunotherapies are surveyed. Lastly, future opportunities for microphysiological systems to address key challenges in the clinical translation of neutrophil-based cancer immunotherapy are discussed.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 58","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13572835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing Methylselenol (CH₃SeH): A Highly Effective Platform for Stimuli-Responsive Delivery With Therapeutic Potential. 甲基硒醇（CH3SeH）：一种具有治疗潜力的刺激反应递送的高效平台。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78356

Wenfang Liang, Liyue Wang, Xuan Wang, Xinran Li, Hao Xing, Lu Sun, Zhen Xi, Long Yi

{"title":"Harnessing Methylselenol (CH3SeH): A Highly Effective Platform for Stimuli-Responsive Delivery With Therapeutic Potential.","authors":"Wenfang Liang, Liyue Wang, Xuan Wang, Xinran Li, Hao Xing, Lu Sun, Zhen Xi, Long Yi","doi":"10.1002/advs.78356","DOIUrl":"10.1002/advs.78356","url":null,"abstract":"Methylselenol (CH3SeH) is not only a key selenium (Se) metabolite but also a potent therapeutic molecule. Chemical tools for stimulus-responsive delivery of CH3SeH should be crucial for exploring Se-related biomedicine. Nevertheless, the classical 1,6-self-immolation is inefficient in releasing the poorly leaving selenol, and donation platforms for triggerable release of the CH3SeH remain lacking. Herein, we report the first general responsive platform (Triggered Donation for MethylSelenol, termed TD-MSe) via fast intramolecular amino-activated methylselenocarbamates (t1/2 = 5 s at pH 7.4), enabling the efficient cyclization release of CH3SeH without electrophilic byproducts. We leverage the caged TD-MSe motifs to successfully create triggered donors that are stable before activation but can liberate CH3SeH under different stimulus conditions in vitro and in live cells. Additionally, we demonstrate that the tumor-associated oxidoreductase (hNQO1)-triggered CH3SeH donor was activated in hNQO1-positive HT-29 cells but not in hNQO1-negative cells. Moreover, we can use the CH3SeH prodrug to selectively kill metastatic cells of hNQO1-overexpressing cancer types, providing a promising therapeutic strategy for difficult-to-treat diseases. We anticipate that the new-release chemistry will be widely applied for developing advanced tools toward smart selenol delivery and therapy.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78356"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

qcGEM: A Graph-Based Molecular Representation With Quantum Chemistry Awareness. qcGEM：具有量子化学意识的基于图的分子表示。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.77997

Haoyu Wang, Ziyan Zhang, Swee Hong Ng, Haipeng Gong

{"title":"qcGEM: A Graph-Based Molecular Representation With Quantum Chemistry Awareness.","authors":"Haoyu Wang, Ziyan Zhang, Swee Hong Ng, Haipeng Gong","doi":"10.1002/advs.77997","DOIUrl":"10.1002/advs.77997","url":null,"abstract":"The advancement of artificial intelligence (AI) has reshaped drug discovery. AI-based models typically rely on molecular representations for prediction. However, the absence of physically grounded information in mainstream molecular representations not only limits the model performance in practical applications but also hinders mechanistic understanding and exploitation by humans. To overcome this issue, we introduce qcGEM, a quantum-chemistry-aware graph-based embedding of molecules that incorporates physical priors into molecular representation learning. Through a specially designed model architecture to adequately process quantum chemistry information, qcGEM provides a compact, physics-informed molecular representation that supports a diverse range of downstream applications. Particularly, qcGEM demonstrates state-of-the-art performance across a broad range of molecule-related benchmarks, as evidenced by comprehensive evaluations on 83 tasks including molecular property prediction, activity cliff detection, protein-ligand interaction modeling, and opioid drug regression, and simultaneously offers strong interpretability at multiple representation levels. We additionally propose a simplified variant, qcGEM-Hybrid, with substantially accelerated embedding generation and robust performance. Overall, our method provides an advanced molecular representation that will benefit molecule-related modeling and prediction, supporting further progress in AI-aided drug discovery.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77997"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation-Induced Turbostratic Ordering in pDCPD-Derived Hard Carbon Enables Stable Carbonate-Based Sodium-Ion Storage. 在pdcpd衍生的硬碳中激活诱导的涡轮有序使稳定的碳酸盐基钠离子存储成为可能。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78311

David Schuster, Glen J Smales, Max Schmallegger, Julian M Rosalie, Konstantin Kraushaar, Andreas Lißner, Julia Bohdal, Pia Winter, Bernd Fuchsbichler, Stefan Koller, Sebastijan Kovačič, Christian Slugovc

{"title":"Activation-Induced Turbostratic Ordering in pDCPD-Derived Hard Carbon Enables Stable Carbonate-Based Sodium-Ion Storage.","authors":"David Schuster, Glen J Smales, Max Schmallegger, Julian M Rosalie, Konstantin Kraushaar, Andreas Lißner, Julia Bohdal, Pia Winter, Bernd Fuchsbichler, Stefan Koller, Sebastijan Kovačič, Christian Slugovc","doi":"10.1002/advs.78311","DOIUrl":"10.1002/advs.78311","url":null,"abstract":"Sodium-ion batteries are widely considered a promising alternative to lithium-ion batteries, due to the abundance and low cost of their raw materials. However, the development of high-performance and cost-effective electrode materials remains a significant challenge, particularly when competing with lithium iron phosphate systems. Herein, we present a hard carbon material derived from readily available poly(dicyclopentadiene) for use as a negative electrode in SIBs. This study investigates the influence of carbonization temperature and subsequent <math><msub><mi>CO</mi> <mn>2</mn></msub> </math> activation on the hard carbon structure and electrochemical performance. The impact of activation proved to be dependent upon the first stage carbonization temperature, creating greater local ordering for samples carbonized at higher temperatures. The removal of defects and increase in interlayer distance resulted in a turbostratic structure that enhanced rate performance and capacity retention when compared with non-activated samples. The optimized hard carbon exhibits a reversible capacity of 352 mAh <math><msup><mi>g</mi> <mrow><mo>-</mo> <mn>1</mn></mrow> </msup> </math> at 0.1 C and a capacity retention of 88.1% after 500 cycles with a carbonate based electrolyte. This work introduces a cost-effective approach for producing hard carbon materials with distinctive nanostructure and provides valuable insights into achieving long cycle life in sodium-ion batteries.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78311"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55-ESCRT-Associated Vesicular Damage Clearance. Tubocapsenolide A通过靶向PLK1损害cep55 - escrt相关的水泡损伤清除来克服结直肠癌的奥沙利铂耐药

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78310

Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen

{"title":"Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55-ESCRT-Associated Vesicular Damage Clearance.","authors":"Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen","doi":"10.1002/advs.78310","DOIUrl":"10.1002/advs.78310","url":null,"abstract":"Oxaliplatin (L-OHP) is a first-line chemotherapeutic agent for advanced colorectal cancer (CRC) and postoperative adjuvant therapy. However, acquired L-OHP resistance remains a clinical obstacle. Here, we identify Tubocapsenolide A (TA), a natural withanolide isolated from Tubocapsicum anomalum, as a promising antitumor agent that suppresses CRC growth and sensitizes L-OHP-resistant CRC to L-OHP. Using a PROTAC-based target deconvolution strategy, we identify PLK1 as a direct molecular target of TA. PLK1 is elevated in L-OHP-resistant CRC and is associated with reduced patient sensitivity to L-OHP. Mechanistically, elevated PLK1 promotes CEP55 Ser436 phosphorylation and facilitates ESCRT recruitment to nuclear and mitochondrial budding sites. This process facilitates the clearance of L-OHP-induced damaged components through nuclear budding and TOM20-/PDH+ mitochondrial-derived vesicles, thereby contributing to organelle homeostasis and cell survival. By inhibiting PLK1, TA interferes with this vesicle-associated damage clearance process, leading to intracellular accumulation of damaged components. This damage accumulation is accompanied by nucleolar stress and mitochondrial dysfunction, ultimately contributing to cell death. Collectively, our findings identify a previously unappreciated role of the PLK1-CEP55-ESCRT axis in vesicle-associated damage clearance during L-OHP resistance and support this axis as a potential therapeutic target. TA represents a promising lead compound for overcoming L-OHP resistance in CRC.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78310"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Peptide-Programmed Liquid-Crystalline Topology Switching for pH-Gated Postoperative Cancer Immunotherapy. 治疗肽编程液晶拓扑切换用于ph门控术后癌症免疫治疗。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78360

Yan Yan, Bin Chen, Yanqing Wang, Yuxi Hou, Zhenlin Ma, Zini Yang, Xia Yin, Yiling Chen, Litao Huang, Menghan Cai, Xinlin Liu, Yi Zhun Zhu, Li Ye

{"title":"Therapeutic Peptide-Programmed Liquid-Crystalline Topology Switching for pH-Gated Postoperative Cancer Immunotherapy.","authors":"Yan Yan, Bin Chen, Yanqing Wang, Yuxi Hou, Zhenlin Ma, Zini Yang, Xia Yin, Yiling Chen, Litao Huang, Menghan Cai, Xinlin Liu, Yi Zhun Zhu, Li Ye","doi":"10.1002/advs.78360","DOIUrl":"10.1002/advs.78360","url":null,"abstract":"Stimuli-responsive depots for postoperative cancer therapy often treat therapeutic payloads as passive cargo, resulting in premature leakage and limited on-demand activation. Herein, we report a therapeutic peptide-programmed liquid-crystalline depot in which the Vpr-derived antitumor peptide (VDAP) functions simultaneously as an immunotherapeutic effector and a supramolecular topology regulator. At physiological pH, cationic α-helical VDAP was electrostatically anchored by oleic acid-containing lipid domains, reinforcing a compact inverse hexagonal (HII) topology associated with reduced peptide diffusion. In the acidic postoperative tumor microenvironment, protonation of oleic acid could disrupt anionic anchoring, whereas histidine protonation within VDAP amplified intrachannel electrostatic repulsion. This cooperative peptide-lipid charge reprogramming could drive graded liquid-crystalline topology remodeling from a diffusion-restrictive HII organization to a more interconnected bicontinuous cubic Im3̄m network, consistent with increased pH-responsive peptide release. In an orthotopic incomplete-resection breast tumor model, the depot induced immunogenic tumor destruction, enhanced damage-associated molecular pattern release, promoted dendritic cell maturation and CD8+ T cell infiltration, and reshaped the immunosuppressive surgical bed. These results demonstrate that electrostatic-topology-gated VDAP-enabled supramolecular topology switching provides effective adaptive local cancer immunotherapy, effectively suppressing postoperative tumor recurrence and attenuating pulmonary metastasis.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78360"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poloxamer-Enabled Thermoresponsive Biobased Controlled-Release Fertilizer for On-Demand Nutrient Delivery. 波洛莫热响应生物基控释肥料，用于按需养分输送。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78371

Jiahui Liu, Junyin Li, Ziyao Li, Xiangjie Zhao, Fengyan Fang, Yan Liu, Songyuan Wang, Boning Su, Yuanyuan Yao, Bin Gao, Shugang Zhang, Yuechao Yang

{"title":"Poloxamer-Enabled Thermoresponsive Biobased Controlled-Release Fertilizer for On-Demand Nutrient Delivery.","authors":"Jiahui Liu, Junyin Li, Ziyao Li, Xiangjie Zhao, Fengyan Fang, Yan Liu, Songyuan Wang, Boning Su, Yuanyuan Yao, Bin Gao, Shugang Zhang, Yuechao Yang","doi":"10.1002/advs.78371","DOIUrl":"10.1002/advs.78371","url":null,"abstract":"Synchronizing nutrient release of fertilizers with crop uptake remains a central challenge in precision agriculture. Here, we present a novel temperature-responsive biobased controlled-release fertilizer (TRBFs) incorporating Poloxamer 407 (F127) as a thermal switch within a castor oil-derived polyurethane coating. The optimized TRBF10 (3 wt.% coating rate, 10 wt.% F127 in coating) exhibits a sharp, reversible phase transition at ∼20°C, matching the phenological requirements of overwintering crops. As quantified by digital refractometry, the 30-day cumulative nitrogen release is suppressed to 9.22% at 10°C (crop dormancy) and increases 8.7-fold to 80.32% at 30°C (active growth). This scalable technology overcomes intrinsic limitations of conventional diffusion-controlled coated fertilizers and offers potential for on-demand nutrient delivery with reduced environmental loss. Our work establishes sustainable strategies for climate-adaptive precision agriculture and offers new insights and design paradigms for intelligent controlled-release materials.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78371"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Data-Driven and Physics-Informed Modeling Perspectives for Soft Manipulators: From SINDy to Hybrid Intelligence. 软机械臂的数据驱动和物理信息建模视角：从SINDy到混合智能。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78334

Wenbo Hui, Yunyi Wang, Teng Zhang, Yang Chen, Min Pan

{"title":"Data-Driven and Physics-Informed Modeling Perspectives for Soft Manipulators: From SINDy to Hybrid Intelligence.","authors":"Wenbo Hui, Yunyi Wang, Teng Zhang, Yang Chen, Min Pan","doi":"10.1002/advs.78334","DOIUrl":"10.1002/advs.78334","url":null,"abstract":"Soft manipulators offer a route to safer, more adaptive and physically intelligent robots, but their compliant bodies remain difficult to model, predict and control. Large deformation, distributed actuation, hysteresis, material variability and contact-rich interaction challenge both classical mechanics-based models and purely data-driven approaches. Here, we examine emerging modeling perspectives for soft manipulators through a conceptual progression from sparse identification of nonlinear dynamics to hybrid intelligence. We discuss how sparse identification of nonlinear dynamics (SINDy), Koopman learning, neural ordinary differential equations, physics-informed neural networks, and hybrid physics machine learning models contribute complementary capabilities, including interpretable reduced-order dynamics, control-ready prediction, continuous-time latent modeling, physics-constrained field reconstruction, and residual correction. We present that no single modeling approach is sufficient for the next generation of soft robotic systems. Instead, progress requires integrated modeling ecosystems that combine mechanical structure, data-driven discovery and task-aware adaptation. Such hybrid-intelligence frameworks can transform models from passive descriptions of deformation into active components of sensing, control, design and decision-making, enabling soft manipulators that are more interpretable, robust and deployable in real-world environments.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78334"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lewis Acid-Catalyzed Strain-Enabled (3+3) Annulation of Bicyclo[1.1.0]Butanes With Indolylalcohols: Synthesis of Indole-Fused Aza-Bicyclo[3.1.1]Heptanes. Lewis酸催化菌株使双环[1.1.0]丁烷与吲哚醇（3+3）环化：吲哚-偶氮-双环[3.1.1]庚烷的合成

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78354

Mainak Dey, Tuhin Subhra Das Mahapatra, Pragya Sharma, Manoj V Mane, Chinmoy Kumar Hazra

引用次数: 0

Magnetoelectric Multiferroics for the Next-Generation Ultralow-Power Electronics. 用于下一代超低功率电子器件的磁电多铁体。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78344

Yang Liu, Yunlong Sun, Hao Luo, Duoduo Zhao, Yuhan Zeng, Xuzihan Zhang, Zhewei Liu, Hao Peng, Zhijing Zhang, Jack Yang, Ji Zhang, Danyang Wang, Junjie Shi, Sean Li

{"title":"Magnetoelectric Multiferroics for the Next-Generation Ultralow-Power Electronics.","authors":"Yang Liu, Yunlong Sun, Hao Luo, Duoduo Zhao, Yuhan Zeng, Xuzihan Zhang, Zhewei Liu, Hao Peng, Zhijing Zhang, Jack Yang, Ji Zhang, Danyang Wang, Junjie Shi, Sean Li","doi":"10.1002/advs.78344","DOIUrl":"10.1002/advs.78344","url":null,"abstract":"Magnetoelectric multiferroics enable voltage control of magnetic states for low-energy, non-volatile memory and logic. Their practical value, however, depends on the complete device pathway, not coupling strength alone. This Review evaluates materials, switching mechanisms, and devices against these requirements, distinguishing measured performance from projected targets. We compare three magnetoelectric random-access memory (MeRAM) routes with ferroelectric RAM and spin-transfer torque magnetic RAM, and assess magnetoelectric spin-orbit (MESO) logic alongside complementary metal-oxide-semiconductor (CMOS) technology and current-driven spintronics. MeRAM combines electric-field writing, magnetic storage, and nondestructive readout, with prospects for low write energy and closer memory-logic integration. However, no integrated device has yet combined these benefits with competitive speed, retention, endurance, read margin, and density. For magnetoelectric logic, projected low-voltage, non-volatile operation has yet to be matched by experimental demonstrations of the full conversion path, gain and fan-out. Results from BiFeO3, room-temperature hexaferrites and other platforms identify deterministic switching, interface quality and thin-film integration as central to closing the gap between projections and experiments. Magnetoelectric devices are therefore more likely to complement CMOS than replace it, particularly in logic-in-memory, compute-near-memory and normally-off systems, where non-volatility and reduced data movement could support next-generation ultralow-power electronics.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78344"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0