Advanced Science最新文献_第3页

Bioprinted Organoids: An Innovative Engine in Biomedicine. 生物打印类器官：生物医学的创新引擎。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202507317

Zhengwei Li, Kai Li, Cheng Zhang, Yingying Zhao, Yiyuan Guo, Jia He, Shiyuan Chang, Xinyi Fang, Kaizheng Liu, Pingping Zhu, Zhenzhen Chen, Changshun Ruan

{"title":"Bioprinted Organoids: An Innovative Engine in Biomedicine.","authors":"Zhengwei Li, Kai Li, Cheng Zhang, Yingying Zhao, Yiyuan Guo, Jia He, Shiyuan Chang, Xinyi Fang, Kaizheng Liu, Pingping Zhu, Zhenzhen Chen, Changshun Ruan","doi":"10.1002/advs.202507317","DOIUrl":"https://doi.org/10.1002/advs.202507317","url":null,"abstract":"Bioprinted organoids integrate bioprinting technology with organoid research, enabling the simultaneous reconstruction of human tissue morphology and physiological function in vitro. This approach offers distinct advantages in organoid fabrication, particularly in terms of structural precision, tissue mimicry, and functional fidelity. By leveraging the complementary strengths of both technologies, bioprinted organoids allow for the fabrication of personalized, architecturally engineered models that more accurately replicate organogenesis, physiological processes, and disease progression. Herein, this review outlines the key advantages of bioprinted organoids, with a focus on their ability to precisely control morphology, dimensions, and spatial organization. Bioprinted organoids are further categorized into three types based on their cellular origins and summarize recent progress in their application for human tissue modeling. Finally, ongoing challenges and future possibilities are sketched out, offering insights for potential innovation and research directions in the field. Bioprinted organoids not only propel the advancement of organoid research but also drive the evolution of bioprinting technologies. This integrated approach represents a powerful synergy between biomanufacturing and clinical medicine to pave the way for a new era in biomedical science and personalized healthcare.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e07317"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca²⁺ Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium. 溶酶体逆行运输的激活触发溶酶体-内质网MCSs的TPC1-IP3R1 Ca2+串扰，导致内质网钙的致命消耗。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202415313

Meng-Yuan Zhu, Yong-Jian Guo, Yu-Qi Zhu, Hong-Zheng Wang, Hai-di Wang, Hong-Yu Chen, Yue-Xin Jiang, Hui Li, Hui Hui

{"title":"Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca2+ Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.","authors":"Meng-Yuan Zhu, Yong-Jian Guo, Yu-Qi Zhu, Hong-Zheng Wang, Hai-di Wang, Hong-Yu Chen, Yue-Xin Jiang, Hui Li, Hui Hui","doi":"10.1002/advs.202415313","DOIUrl":"https://doi.org/10.1002/advs.202415313","url":null,"abstract":"Inter-organellar signaling linkages in oncology are increasingly elucidated. However, the impact of lysosome-endoplasmic reticulum (ER) interaction on tumor cell fate remains relatively unexplored. A novel interaction between lysosomes and the ER, mediated by the flavonoid LW-213 through targeting LIMP2 (lysosomal integral membrane protein type 2)to activate a lysosomal repair pathway, is identified in acute myeloid leukemia (AML). This leads to activated RAB7A activity, enhancing lysosomal retrograde transport to the perinuclear region and increasing contact at lysosome-ER membrane contact sites (MCSs). Close proximity of TPC1 to IP3R1 at these sites generates a concentrated calcium microdomain, triggering Ca2+-induced Ca2+ release, which causes cytoplasmic calcium turbulence and two distinct calcium tides. This excessive calcium efflux depletes ER calcium stores, triggering lethal ER stress-induced apoptosis. Interestingly, altering TPC1 expression levels in HeLa cells affected these calcium dynamics, replicating AML-specific mechanisms when overexpressed. Subsequent studies using BALB/c xenograft models with wild-type and LIMP2-knockout THP1 cells, along with ICR mice toxicity models, confirmed LW-213's significant tumor growth inhibition with minimal toxicity. These findings underscore the potential of targeting lysosomal-ER calcium crosstalk as an innovative approach to cancer treatment, highlighting the therapeutic promise of LW-213 in managing tumor cell fate through modulating organellar interactions.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e15313"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast Li₂O₂ Electrochemistry Enabled by Co-N_x/Co (111) with Optimized Intermediate Adsorption. 优化中间吸附的Co- nx /Co（111）实现Li₂O₂快速电化学

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202510256

Lili Liu, Chen Wang, Luxin Zhao, Yayun Xiao, Weiwei Fang, Lanling Zhao, Faxing Wang, Yuping Wu

{"title":"Fast Li₂O₂ Electrochemistry Enabled by Co-Nx/Co (111) with Optimized Intermediate Adsorption.","authors":"Lili Liu, Chen Wang, Luxin Zhao, Yayun Xiao, Weiwei Fang, Lanling Zhao, Faxing Wang, Yuping Wu","doi":"10.1002/advs.202510256","DOIUrl":"https://doi.org/10.1002/advs.202510256","url":null,"abstract":"The practical development of Li-O2 batteries (LOBs) urgently needs to explore robust cathode catalysts to boost the sluggish Li2O2 reaction kinetics and parasitic reactions despite their theoretically high specific energy. Profound understanding of the cathode properties and the battery performance is rather critical in developing rational-designed electrocatalysts. In this study, a Co-Nx/Co (111) decorated N-doped hierarchical carbon framework (Co-Nx/Co@NHCF) is proposed as an efficient cathode in LOBs. Spectroscopic analysis coupled with experimental results suggests that the Co-Nx/Co (111) catalytic center can significantly reduce the battery overpotential, and meanwhile, the hierarchical carbon framework ensures rapid mass transportation and provides sufficient space to accommodate Li2O2 deposition. Density functional theory calculations reveal that the incorporated Co (111) facet can effectively regulate the electronic distribution of N-carbon, optimize the adsorption of desirable intermediates, and eventually facilitate oxygen reduction reaction/oxygen evolution reaction kinetics. As expected, the Co-Nx/Co@NHCF catalyzed LOBs deliver a high discharge/charge capacity of 6.15/ 6.22 mAh cm-2 with a columbic efficiency of 98.9%, along with a high rate cycling of 700 h at 0.3 mA cm-2. This work provides valuable instruction for the rational design of efficient catalysts for high-performance LOBs via optimization of the crystal structure and the adsorption of intermediates.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e10256"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia. 血浆代谢谱与机器学习揭示病理性近视的独特诊断和生物学特征。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202505861

Ziheng Qi, Jiao Qi, Ye Zhang, Yanhui Wang, Yuchen Feng, Zifan Yang, Yating Wang, Weikang Shu, Dongling Guo, Ching Kang, Keke Zhang, Yi Lu, Jingjing Wan, Xiangjia Zhu

{"title":"Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia.","authors":"Ziheng Qi, Jiao Qi, Ye Zhang, Yanhui Wang, Yuchen Feng, Zifan Yang, Yating Wang, Weikang Shu, Dongling Guo, Ching Kang, Keke Zhang, Yi Lu, Jingjing Wan, Xiangjia Zhu","doi":"10.1002/advs.202505861","DOIUrl":"https://doi.org/10.1002/advs.202505861","url":null,"abstract":"Pathologic myopia (PM), characterized by serious myopic macular degeneration (MMD), is a detrimental subtype of high myopia (HM) and has become one of the leading causes of blindness worldwide. In this concern, precise and high-throughput molecular diagnosis and further pathologic insights are urgently needed. Here, through the combined strategy of nanoparticle-enhanced laser desorption/ionization mass spectrometry-based rapid metabolic analysis (<30 s) and machine learning, a precise molecular diagnostic approach of PM (HM with MMD grade ≥ 2) is proposed, which achieves areas under the curve of 0.874 and 0.889 for diagnosing PM and early-stage PM, respectively. Further, the biomarkers indicate the PM-associated systemic metabolic reprogramming of amino acid and lipid metabolism, which may mediate dysfunctional oxidative stress, inflammation, hormone/neurotransmitter systems, and energy metabolism. Notably, MMD grade 4, featuring characteristic macula atrophy, exhibits specificity in this metabolic reprogramming. Of these biomarkers, azelaic acid shows a significant protective effect in the ARPE-19 cells under abnormal oxidative stress, which may be involved in PM development as a key antioxidative active metabolite. This work will contribute to PM molecular diagnosis and pathology exploration.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e05861"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Oxygen Vacancies in LiCoO₂ on the Electrochemical Performance of Garnet-Based All-Solid-State Li-Metal Batteries. LiCoO2中氧空位对石榴石基全固态锂金属电池电化学性能的影响

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202508750

Zhizhen Qin, Jehad Ahmed, Sebastian Speer, Dmitri L Danilov, Anna Windmüller, Shicheng Yu, Chih-Long Tsai, Hermann Tempel, Josef Granwehr, Wen-Wei Wu, Jeng-Kuei Chang, Rüdiger-A Eichel, Peter H L Notten

{"title":"Impact of Oxygen Vacancies in LiCoO2 on the Electrochemical Performance of Garnet-Based All-Solid-State Li-Metal Batteries.","authors":"Zhizhen Qin, Jehad Ahmed, Sebastian Speer, Dmitri L Danilov, Anna Windmüller, Shicheng Yu, Chih-Long Tsai, Hermann Tempel, Josef Granwehr, Wen-Wei Wu, Jeng-Kuei Chang, Rüdiger-A Eichel, Peter H L Notten","doi":"10.1002/advs.202508750","DOIUrl":"https://doi.org/10.1002/advs.202508750","url":null,"abstract":"Garnet-structured Li7La3Zr2O7 (LLZO) is considered as one of the most promising solid electrolytes for high safety all-solid-state Li batteries (SSLBs) applications. However, this type of SSLB utilizing LiCoO2/LLZO as composite cathode faces high capacity degradation because of delamination between LiCoO2 (LCO) and LLZO and possible oxygen vacancy-driven microcrack formation within LCO. Herein, a pure oxygen atmosphere is used for sintering the composite cathode to limit oxygen vacancy formation in LCO. Different sintering temperatures are also used to reduce the effect of sintering atmospheres, which suggests the non-reversible oxidation peak at ∼3.8 V is not related to Li2CO3 formation. Although the Coulombic efficiencies of the first electrochemical cycle of SSLBs sintered in pure oxygen atmosphere are improved, their electrochemical performances are lower than that of air-sintered SSLB due to higher cell resistances from the reduction of oxygen vacancies in LCO and possible higher volume change during electrochemical cycling. Also, the lower electrochemical cycling performance and observing tens of micrometers long inter-granular cracks in the highly dense composite cathode suggests that microstructural optimization is more important than a high relative density. These observations provide guidelines for further improving the electrochemical cycling performance of garnet-structure-based SSLBs toward practical applications.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e08750"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene. 聚四氟乙烯致精子质量下降的治疗修复。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202505148

Shiming Gan, Shumin Zhou, Jiaming Zhou, Guanghui Zhang, Jingshou Chen, Rui Liu, Kuan Sun, Sisi Li, Wenjing Xiong, Yujiao Wen, Jianzhong Sheng, Yu Zhang, Jingchao Ren, Youjiang Li, Hefeng Huang, Chen Zhang

{"title":"Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene.","authors":"Shiming Gan, Shumin Zhou, Jiaming Zhou, Guanghui Zhang, Jingshou Chen, Rui Liu, Kuan Sun, Sisi Li, Wenjing Xiong, Yujiao Wen, Jianzhong Sheng, Yu Zhang, Jingchao Ren, Youjiang Li, Hefeng Huang, Chen Zhang","doi":"10.1002/advs.202505148","DOIUrl":"https://doi.org/10.1002/advs.202505148","url":null,"abstract":"The alarming prevalence of environmental microplastics has raised global concerns about fertility. However, the detriment of polytetrafluoroethylene (PTFE, Teflon), a widely used microplastic in non-stick cookware, to sperm quality remains unclear. Here, a high detection rate (46.62%) and bioaccumulation of PTFE in the male urogenital system are reported and the mechanisms of PTFE exposure on male fertility are investigated in both humans and mice and potential therapeutic strategies are explored. These findings reveal that PTFE exposure delays the development of spermatogonia and spermatocytes, disrupts chromosomal synapsis and the DNA damage response, and promotes the apoptosis of spermatocytes. Interestingly, PTFE exposure specifically targets SKAP2 in the haploid spermatid, leading to disruption of the sperm cytoskeleton, abnormal sperm morphology, and decreased sperm motility. Strikingly, therapy targeting SKAP2 remodels sperm cytoskeleton and morphology and restores sperm motility and male fertility in humans and mice. Collectively, these works illustrate the mechanisms of PTFE exposure impairing spermatogenesis and highlight SKAP2 targeting as a promising therapeutic strategy for treating asthenoteratozoospermia in humans.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e05148"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Domain-Wall Driven Suppression of Thermal Conductivity in a Ferroelectric Polycrystal. 畴壁驱动对铁电多晶热导率的抑制。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202506931

Rachid Belrhiti-Nejjar, Manuel Zahn, Patrice Limelette, Max Haas, Lucile Féger, Isabelle Monot-Laffez, Nicolas Horny, Dennis Meier, Fabien Giovannelli, Jan Schultheiß, Guillaume F Nataf

{"title":"Domain-Wall Driven Suppression of Thermal Conductivity in a Ferroelectric Polycrystal.","authors":"Rachid Belrhiti-Nejjar, Manuel Zahn, Patrice Limelette, Max Haas, Lucile Féger, Isabelle Monot-Laffez, Nicolas Horny, Dennis Meier, Fabien Giovannelli, Jan Schultheiß, Guillaume F Nataf","doi":"10.1002/advs.202506931","DOIUrl":"https://doi.org/10.1002/advs.202506931","url":null,"abstract":"A common strategy for reducing the thermal conductivity of polycrystalline systems is to increase the number of grain boundaries. Indeed, grain boundaries enhance the probability of phonon scattering events, which has been applied to control the thermal transport in a wide range of materials, including hard metals, diamond, oxides, and two-dimensional (2D) systems such as graphene. Here, the opposite behavior in improper ferroelectric ErMnO3 polycrystals is reported, where the thermal conductivity decreases with increasing grain size. This unusual relationship between heat transport and microstructure is attributed to phonon scattering at ferroelectric domain walls. The domain walls are more densely packed in larger grains, leading to an inversion of the classical grain-boundary-dominated transport behavior. The findings open additional avenues for microstructural engineering of materials for thermoelectric and thermal management applications, enabling simultaneous control over mechanical, electronic, and thermal properties.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e06931"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics. RAB5A通过重编程乳腺癌球体力学促进主动润湿。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202503569

Grégoire Lemahieu, Paulina Moreno-Layseca, Tobias Hub, Carlo Bevilacqua, Manuel Gómez-González, Federica Pennarola, Federico Colombo, Andrew E Massey, Leonardo Barzaghi, Andrea Palamidessi, Leon-Luca Homagk, Samuel F H Barnett, Alexander X Cartagena-Rivera, Christine Selhuber-Unkel, Robert Prevedel, Xavier Trepat, Joachim P Spatz, Johanna Ivaska, Giorgio Scita, Elisabetta Ada Cavalcanti-Adam

{"title":"RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics.","authors":"Grégoire Lemahieu, Paulina Moreno-Layseca, Tobias Hub, Carlo Bevilacqua, Manuel Gómez-González, Federica Pennarola, Federico Colombo, Andrew E Massey, Leonardo Barzaghi, Andrea Palamidessi, Leon-Luca Homagk, Samuel F H Barnett, Alexander X Cartagena-Rivera, Christine Selhuber-Unkel, Robert Prevedel, Xavier Trepat, Joachim P Spatz, Johanna Ivaska, Giorgio Scita, Elisabetta Ada Cavalcanti-Adam","doi":"10.1002/advs.202503569","DOIUrl":"https://doi.org/10.1002/advs.202503569","url":null,"abstract":"Unjamming transitions from a solid-like to a fluid-like state are a gateway to breast epithelial cancer invasion. However, the mechanical interplay between phase transitions and dimension transitions, in particular wetting, remains elusive, despite being critical for understanding the onset of metastatic dissemination. This study shows that unjamming, mediated by the RAB5A GTPase, alters carcinoma spheroid fluidity, rigidity, and rewires adhesion mechanics to drive supracellular active wetting as a new mode of tumor expansion. Spheroid fluidification enhances the selective expression of integrin subunits and increases focal adhesion dynamics, inducing a fluid-like spreading behavior on specific matrix ligands. Notably, nanoscale regulation of integrin clustering can select for distinct phase transitions at the collective scale upon wetting. In this framework, fluidized spheroids polarize into cohesive \"supracells\", and maintain a stiff peripheral actin bundle as measured by nanomechanical mapping. Furthermore, a combination of Brillouin microscopy and 2.5D traction force analysis reveals a mechanical switch within the spheroid core, characterized by significant cell softening and a reduction in compressive forces exerted on the substrate, thereby mimicking the wetting of a liquid droplet. These findings establish unjamming-driven active wetting as a key mechanism to comprehend the molecular and biophysical underpinnings of solid tumor invasion.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e03569"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Bacteria-Based Cancer Immunotherapy: Comment on "Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics". 探索以细菌为基础的癌症免疫治疗：对“肿瘤内溶瘤细菌靶向抗癌治疗的发现”的评论。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202506869

Chen-Xi Li, Zhong-Cheng Gong

引用次数: 0

Glucose Deprivation-Induced Disulfidptosis via the SLC7A11-INF2 Axis: Pan-Cancer Prognostic Exploration and Therapeutic Validation. 通过SLC7A11-INF2轴诱导的葡萄糖剥夺诱导的双侧下垂：泛癌症预后探索和治疗验证。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202408556

Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu

{"title":"Glucose Deprivation-Induced Disulfidptosis via the SLC7A11-INF2 Axis: Pan-Cancer Prognostic Exploration and Therapeutic Validation.","authors":"Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu","doi":"10.1002/advs.202408556","DOIUrl":"https://doi.org/10.1002/advs.202408556","url":null,"abstract":"Disulfidptosis, a novel form of regulated cell death, involves cytoskeletal collapse due to excessive disulfide bond formation, linking metabolism and reactive oxygen species to potential cancer therapy targets. Recent multi-omics studies highlight the prognostic value of disulfidptosis-related gene (DRG) signatures in pan-cancers; however, the molecular mechanisms underlying their biological functions and therapeutic relevance remain poorly defined. Herein, a DRG score model is constructed using LASSO Cox regression across 33 cancer types, and a nomogram incorporating the DRG score is developed for prognostic prediction. The tumor microenvironment, mutation profiles, and immunotherapy responses are analyzed. The DRG score serves as an independent prognostic factor across cancers, correlating with poor outcomes and malignant features. Glucose deprivation induces disulfidptosis in SLC7A11high cells (high SLC7A11 expression), especially in cancers with a high DRG score, such as ovarian cancer. Silencing INF2 prevents disulfidptosis and decreases susceptibility to irofulven, which can be reversed by GLUT inhibitors. SLC7A11 knockdown reduces disulfidptosis, restores ATP/NADPH levels, and protects the cytoskeleton under glucose deprivation, whereas INF2 knockdown impairs cell migration. Moreover, the DRG scores predict prognosis and therapeutic responses. The SLC7A11-INF2 axis regulates disulfidptosis, migration, and drug sensitivity, highlighting its potential as a marker of metabolic vulnerability in ovarian cancer.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e08556"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0