Advanced SciencePub Date : 2025-01-31DOI: 10.1002/advs.202416053
Kaibin Chu, Bo Weng, Zhaorui Lu, Yang Ding, Wei Zhang, Rui Tan, Yu-Ming Zheng, Ning Han
{"title":"Exploration of Multidimensional Structural Optimization and Regulation Mechanisms: Catalysts and Reaction Environments in Electrochemical Ammonia Synthesis.","authors":"Kaibin Chu, Bo Weng, Zhaorui Lu, Yang Ding, Wei Zhang, Rui Tan, Yu-Ming Zheng, Ning Han","doi":"10.1002/advs.202416053","DOIUrl":"https://doi.org/10.1002/advs.202416053","url":null,"abstract":"<p><p>Ammonia (NH<sub>3</sub>) is esteemed for its attributes as a carbon-neutral fuel and hydrogen storage material, due to its high energy density, abundant hydrogen content, and notably higher liquefaction temperature in comparison to hydrogen gas. The primary method for the synthetic generation of NH<sub>3</sub> is the Haber-Bosch process, involving rigorous conditions and resulting in significant global energy consumption and carbon dioxide emissions. To tackle energy and environmental challenges, the exploration of innovative green and sustainable technologies for NH<sub>3</sub> synthesis is imperative. Rapid advances in electrochemical technology have created fresh prospects for researchers in the realm of environmentally friendly NH<sub>3</sub> synthesis. Nevertheless, the intricate intermediate products and sluggish kinetics in the reactions impede the progress of green electrochemical NH<sub>3</sub> synthesis (EAS) technologies. To improve the activity and selectivity of the EAS, which encompasses the electrocatalytic reduction of nitrogen gas, nitrate, and nitric oxide, numerous electrocatalysts and design strategies have been meticulously investigated. Here, this review primarily delves into recent progress and obstacles in EAS pathways, examining methods to boost the yield rate and current efficiency of NH<sub>3</sub> synthesis via multidimensional structural optimization, while also exploring the challenges and outlook for EAS.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2416053"},"PeriodicalIF":14.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Piezoelectric Biomaterial with Advanced Design for Tissue Infection Repair.","authors":"Siyuan Shang, Fuyuan Zheng, Wen Tan, Zhengyi Xing, Siyu Chen, Fuli Peng, Xiang Lv, Duan Wang, Xiangdong Zhu, Jiagang Wu, Zongke Zhou, Xingdong Zhang, Xiao Yang","doi":"10.1002/advs.202413105","DOIUrl":"https://doi.org/10.1002/advs.202413105","url":null,"abstract":"<p><p>Bacterial infection has become the most dangerous factor in tissue repair, which strongly affects the tissue regeneration efficiency and wellness of patients. Piezoelectric materials exhibit the outstanding advantage of producing electrons without external power supply. The ability of electron enrichment and reactive oxygen species generation through noninvasive stimulations enables piezoelectric materials the potential applications of antibacterial. Many studies have proved the feasibility of piezoelectric materials as a functional addition in antibacterial biomaterial. In fact, numerous piezoelectric materials with ingenious designs are reported to be effective in antibacterial processes. This review summarizes the antibacterial mechanisms of piezoelectric, illuminating their potential in combating bacteria. Recent advancement in the design and construction of piezoelectric biomaterial including defect engineering, heterojunction, synergy with metal and the composite scaffold configuration are thoroughly reviewed. Moreover, the applications and therapeutic effects of piezoelectric materials in common tissues with antibacterial requirements are introduced, such as orthopedics, dental, and wound healing. Finally, the development prospects and points deserving further exploration are listed. This review is expected to provide valuable insight into the relationship between antibacterial processes and piezoelectric materials, further inspiring constructive development in this emerging scientific discipline.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413105"},"PeriodicalIF":14.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-01-31DOI: 10.1002/advs.202411994
Haijie Zhang, Xia Xiao, Chenlong Wang, Yurong Zhao, Bo Chen, Xinyuan Ji, Lina Gu, Jie Wang, Zhiqiang Wang, Yuan Liu
{"title":"DNA Polymerase IV dinB Favors the Adaptive Fitness of mcr-carrying Bacteria Through a Negative Feedback Regulatory Mechanism.","authors":"Haijie Zhang, Xia Xiao, Chenlong Wang, Yurong Zhao, Bo Chen, Xinyuan Ji, Lina Gu, Jie Wang, Zhiqiang Wang, Yuan Liu","doi":"10.1002/advs.202411994","DOIUrl":"https://doi.org/10.1002/advs.202411994","url":null,"abstract":"<p><p>The plasmid-borne resistance gene mcr drastically undermines the effectiveness of colistin, posing a substantial threat to public health. Although several key plasmid elements that balance mcr-1 persistence and bacterial growth are identified, the regulatory interactions between mcr-1 and host bacteria remain poorly understood. Using a genome-wide CRISPRi crRNA library, it is identified that DNA polymerase IV, dinB, is essential for controlling the fitness cost associated with mcr-1 in Escherichia coli. The absence of dinB operon enhances mcr-1-mediated colistin resistance but simultaneously compromises bacterial growth and competitiveness. Meanwhile, dinB deficiency mitigates inflammatory response in RAW267.4 cells and enhances bacterial colonization in murine tissues. Further investigation reveals that mcr-1 actively upregulates dinB expression, with the increased reactive oxygen species induced by mcr-1 being crucial for this activation. These findings suggest that dinB modulates mcr expression and bacterial fitness via a negative feedback regulatory mechanism. Leveraging this regulatory relationship, a Toxin-Intein is engineered under the control of dinB promoter to selectively target and kill mcr-positive E. coli both in vitro and in vivo. Overall, the work uncovers a novel adaptive mechanism underlying mcr persistence and provides a precise antimicrobial strategy to combat antibiotic-resistant pathogens.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2411994"},"PeriodicalIF":14.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Temporal Association Cortex Gates Sound-Evoked Arousal from NREM Sleep.","authors":"Haipeng Yu, Jincheng Wang, Ruiqi Pang, Penghui Chen, Tiantian Luo, Xuan Zhang, Yatao Liao, Chao Hu, Miaoqing Gu, Bingmin Luo, Zhiyue Shi, Mengyao Li, Yueting Zhang, Qiaoqian Wei, Wei Yuan, Hui Xie, Zhiyi Chen, Hongbang Liu, Shuancheng Ren, Xiaowei Chen, Yi Zhou","doi":"10.1002/advs.202414271","DOIUrl":"https://doi.org/10.1002/advs.202414271","url":null,"abstract":"<p><p>Sound-evoked wakefulness from sleep is crucial in daily life, yet its neural mechanisms remain poorly understood. It is found that CaMKIIα+ neurons in the temporal association cortex (TeA) of mice are not essential for natural awakening from sleep. However, optogenetic activation of these neurons reliably induces wakefulness from non-rapid eye movement (NREM) sleep but not from rapid eye movement (REM) sleep. In vivo electrophysiological and calcium recordings further demonstrated that TeA neurons are monotonically tuned to sound intensity but not frequency. More importantly, it is found that the activity of CaMKIIα+ neurons in TeA can gate sound-evoked arousal from NREM sleep, which is further confirmed by optogenetic manipulations. Further investigation reveals that the baseline excitability of TeA CaMKIIα+ neurons and the delta oscillations in the electroencephalogram are particularly important in regulating the evoked activity of TeA neurons. Anatomical and functional screening of downstream targets of TeA reveals that excitatory projections from TeA glutamatergic neurons to glutamatergic neurons in the basolateral/lateral amygdala are critical for modulating sound-evoked arousal from NREM sleep. These findings uncover a top-down regulatory circuit that selectively governs sound-evoked arousal from NREM sleep, with the TeA functioning as a key connecting cortex to subcortical regions.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2414271"},"PeriodicalIF":14.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-01-31DOI: 10.1002/advs.202415260
Yu An, Zhaocun Shen, Fang Zhang, Qiuya Yang, Zihan Han, Mingjie Wang, Hongze Ma, Linjie Yu, Wei Yuan, Kunyan Sui
{"title":"Inversion of Circularly Polarized Luminescence in the Left-Handed Chitosan-Templated Co-assemblies.","authors":"Yu An, Zhaocun Shen, Fang Zhang, Qiuya Yang, Zihan Han, Mingjie Wang, Hongze Ma, Linjie Yu, Wei Yuan, Kunyan Sui","doi":"10.1002/advs.202415260","DOIUrl":"https://doi.org/10.1002/advs.202415260","url":null,"abstract":"<p><p>Circularly polarized luminescence (CPL) materials are attractive due to their unique applications in fields such as 3D displays, information encryption, and chiroptical switches. Natural biomolecules-based CPL materials are gaining plenty of attention due to their chiral diversity and sustainability. However, it is still challenging to construct CPL materials with opposite CPL signs from a single natural biomolecule due to its inherent chirality. Here, chiral assemblies with opposite CPL signs using chitosan oligosaccharide (COS) and achiral luminescent dyes are successfully prepared. It is found that COS can serve as a chiral template to induce the ordered assembly of the dyes along the polymer chain through electrostatic attraction interaction. It is demonstrated experimentally that the structural planarity of the dye molecules is crucial for the formation of chiral co-assemblies. Interestingly, the left-handed COS-templated co-assemblies can emit CPL with opposite handedness, which is controlled by the helicity degree of the co-assemblies. This study not only deepens the understanding of the complex assembly of natural biomacromolecules but also provides new insights into the design and construction of CPL materials.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2415260"},"PeriodicalIF":14.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Redox-Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3-Mediated NRF2 Deubiquitination.","authors":"Weimin Xu, Zhebin Hua, Yaosheng Wang, Wenbo Tang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Yubei Gu, Chen-Ying Liu, Peng Du","doi":"10.1002/advs.202411320","DOIUrl":"https://doi.org/10.1002/advs.202411320","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) is associated with oxidative stress and redox signaling disruption. It is recently reported that proautophagic autophagy/beclin-1 regulator 1 (AMBRA1) is a positive modulator of the NF-κB pathway that promotes intestinal inflammation. However, its effect on intestinal redox state and whether AMBRA1 is regulated by oxidative stress remain unknown. In this study, it is found that AMBRA1 functions as a pro-oxidative factor that increases oxidative stress in intestinal epithelial cells (IECs) in vitro and in vivo. Mechanistically, the N-terminal F1 domain is required for AMBRA1 to competitively interact with the N-terminal domain of NRF2, thereby antagonizing the interaction between deubiquitinating protein 3 (DUB3) and NRF2, suppressing DUB3-mediated NRF2 deubiquitination, and leading to NRF2 degradation. In response to H<sub>2</sub>O<sub>2</sub> stimulation, the interaction between AMBRA1 and ubiquitin-specific protease 7 (USP7) is enhanced, facilitating USP7 to deubiquitinate AMBRA1 at K83 and K86 and stabilize AMBRA1. Notably, the USP7 inhibitor, P5091, inhibits oxidative stress and colitis in vivo. Elevated AMBRA1 expression in inflamed colon tissues from ulcerative colitis patients is negatively correlated with decreased NRF2 protein levels. Overall, this study identifies AMBRA1 as a pro-oxidative factor in IECs and provides a redox-modulating therapeutic strategy for targeting USP7/AMBRA1 in IBD.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2411320"},"PeriodicalIF":14.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Transformative Wearable Corneal Microneedle Patch for Efficient Therapy of Ocular Injury and Infection.","authors":"Xue Jiang, Shuhua Liu, Jiayi Chen, Jiapeng Lei, Wenjing Meng, Xueyang Wang, Zhigang Chu, Wei Li","doi":"10.1002/advs.202414548","DOIUrl":"https://doi.org/10.1002/advs.202414548","url":null,"abstract":"<p><p>Ocular injury and infection are significant causes of vision impairment and blindness globally. Effective treatment is, however, challenging due to the physical barrier of the cornea, which restricts drug penetration in the eye, as well as the presence of eye injury that necessitates continuous delivery of growth factors on the ocular surface for cornea healing. Here, we introduce a transformative wearable corneal microneedle (MN) patch designed for efficient therapy of ocular injury and infection. The MN patch comprises water-soluble tips that encapsulate antibacterial nanoparticles (NPs), along with a transformative backing layer that contains epidermal growth factor (EGF). Upon insertion into the eye, the MN tips dissolve swiftly within the cornea stroma, resulting in the release of the antimicrobial NPs to efficiently eradicate bacteria. Meanwhile, the residual backing layer undergoes rapid in situ transformation upon contact with mildly acidic fluid from infected corneal edema, converting into a contact lens that conforms to the eye's surface, which facilitates sustained release of EGF on the ocular surface over 8 h to promote corneal healing. Benefiting from these features, the designed transformative corneal MN patch demonstrates superior efficacy in treating ocular injuries and infections in vivo, offering a promising therapeutic strategy to manage eye diseases.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2414548"},"PeriodicalIF":14.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models.","authors":"Zhixiong Cai, Zhenli Li, Wenting Zhong, Fangzhou Lin, Xiuqing Dong, Honghao Ye, Yutong Guo, Geng Chen, Xiaoling Yu, Haijun Yu, Ruijing Tang, Xiaolong Liu","doi":"10.1002/advs.202407976","DOIUrl":"https://doi.org/10.1002/advs.202407976","url":null,"abstract":"<p><p>The immunosuppressive microenvironment in pancreatic cancer, characterized by low tumor-specific T cells and excessive fibrosis, limits the effectiveness of immunotherapy. Here, three datasets and multi-immunofluorescence staining of tissue microarrays in pancreatic cancer indicate that mesothelin (MSLN) expression negatively correlates with cytotoxic T cells in tumor. Anti-MSLN antibody (αMSLN) treatment of pancreatic cancer in vivo can significantly increase T cell infiltration. Meanwhile, the combination of αMSLN and neoantigen peptide vaccine identified from pancreatic cancer cell lines is demonstrated to be more effective in inducing neoantigen-specific T cell generation and infiltration at subcutaneous and orthotopic pancreatic cancer models for enhancing antitumor efficacy. Single-cell transcriptome analysis shows that the combined treatment significantly reduces the proportion of fibroblasts, improves the infiltration of IFN-γ<sup>+</sup>CD4<sup>+</sup> and GZMK<sup>+</sup>CD8<sup>+</sup> T cells, as well as reduces the interaction of antigen presentation-associated ligands and receptors between antigen-presenting Cancer-Associated Fibroblasts (apCAFs) and naive CD4<sup>+</sup> T cells. The negative correlations between apCAFs and CD8<sup>+</sup> T cells/IFN-γ<sup>+</sup>CD4<sup>+</sup> T cells are further confirmed in human pancreatic cancer tissues. Overall, this study demonstrates that targeting MSLN can improve neoantigen vaccine induced immune efficacy by reducing apCAFs to interrupt the conversion of naive CD4<sup>+</sup> T cells to Tregs, and therefore increase the infiltration of tumor-specific T cells.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2407976"},"PeriodicalIF":14.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-01-31DOI: 10.1002/advs.202407262
Nadia Rouatbi, Adam A Walters, Alaa Zam, Yau Mun Lim, Alessia Marrocu, Revadee Liam-Or, Joanne E Anstee, James N Arnold, Julie Tzu-Wen Wang, Steven M Pollard, Khuloud T Al-Jamal
{"title":"CD47 Knock-Out Using CRISPR-Cas9 RNA Lipid Nanocarriers Results in Reduced Mesenchymal Glioblastoma Growth In Vivo.","authors":"Nadia Rouatbi, Adam A Walters, Alaa Zam, Yau Mun Lim, Alessia Marrocu, Revadee Liam-Or, Joanne E Anstee, James N Arnold, Julie Tzu-Wen Wang, Steven M Pollard, Khuloud T Al-Jamal","doi":"10.1002/advs.202407262","DOIUrl":"https://doi.org/10.1002/advs.202407262","url":null,"abstract":"<p><p>Immune checkpoint (ICP) blockade has shown limited effectiveness in glioblastoma (GBM), particularly in the mesenchymal subtype, where interactions between immune cells and glioblastoma cancer stem cells (GSCs) drive immunosuppression and therapy resistance. Tailoring ICPs specific to GSCs can enhance the antitumor immune response. This study proposes the use of lipid nanoparticles (LNPs) encapsulating CRISPR RNAs as an in vivo screening tool for ICPs in a syngeneic model of mesenchymal GSCs. Using PD-L1 and CD47 to validate the proof of concept, intratumoral administration of LNPs in orthotopic tumors achieved efficient editing of ICPs, leading to enhanced immune cell infiltration within the tumor microenvironment. Targeting CD47 reduced tumor growth, suggesting improved cancer cell sensitization to the immune system post-ICP editing. The study positions LNPs as a robust tool for in vivo validation of ICPs as therapeutic targets in clinically relevant GBM models. LNPs could serve as a screening tool in patient-derived xenografts to identify and optimize ICP combinations, potentially expediting ICP translation and enhancing personalized GBM immunotherapies.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2407262"},"PeriodicalIF":14.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced SciencePub Date : 2025-01-31DOI: 10.1002/advs.202500579
Haeyong Shin, Sang-Mun Jung, Young Jin Lim, O-Jung Yim, Byung-Jo Lee, Kyu-Su Kim, In-Ho Baek, Jinwoo Baek, Jinhyeon Lee, Yong-Tae Kim
{"title":"Highly Efficient and Durable Ammonia Electrolysis Cell Using Zirfon Separator.","authors":"Haeyong Shin, Sang-Mun Jung, Young Jin Lim, O-Jung Yim, Byung-Jo Lee, Kyu-Su Kim, In-Ho Baek, Jinwoo Baek, Jinhyeon Lee, Yong-Tae Kim","doi":"10.1002/advs.202500579","DOIUrl":"https://doi.org/10.1002/advs.202500579","url":null,"abstract":"<p><p>Most studies on ammonia electrolysis have focused on anion exchange membranes (AEMs), which face limitations in operating conditions, such as pH and ammonia concentration. This study introduces a novel concept of an ammonia electrolysis cell (AEC) utilizing a Zirfon separator capable of operating under high pH and ammonia concentrations. The Zirfon-based AECs achieve a peak current density of 915 mA cm<sup>-2</sup>, representing the highest reported value in AEC literature. Additionally, the Zirfon separator exhibits less conductivity degradation than AEMs during cycling tests (Zirfon 14.1%, AEMs 30.2%), demonstrating superior durability of the Zirfon-based AEC.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2500579"},"PeriodicalIF":14.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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