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Accurate Diagnosis of Lower Respiratory Infections Using Host Response and Respiratory Microbiome from a Single Metatranscriptome Test of Bronchoalveolar Lavage Fluid.
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202405087
Xiaohui Zou, Mengwei Yan, Yeming Wang, Yawen Ni, Jiankang Zhao, Binghuai Lu, Bo Liu, Bin Cao
{"title":"Accurate Diagnosis of Lower Respiratory Infections Using Host Response and Respiratory Microbiome from a Single Metatranscriptome Test of Bronchoalveolar Lavage Fluid.","authors":"Xiaohui Zou, Mengwei Yan, Yeming Wang, Yawen Ni, Jiankang Zhao, Binghuai Lu, Bo Liu, Bin Cao","doi":"10.1002/advs.202405087","DOIUrl":"https://doi.org/10.1002/advs.202405087","url":null,"abstract":"<p><p>Lower respiratory tract infections (LRTIs) diagnosis is challenging because noninfectious diseases mimic its clinical features. The altered host response and respiratory microbiome following LRTIs have the potential to differentiate LRTIs from noninfectious respiratory diseases (non-LRTIs). Patients suspected of having LRTIs are retrospectively enrolled and a clinical metatranscriptome test is performed on bronchoalveolar lavage fluid (BALF). Transcriptomic and metagenomic analysis profiled the host response and respiratory microbiome in patients with confirmed LRTI (n = 126) or non-LRTIs (n = 75). Patients with evidenced LRTIs exhibited enhanced pathways on chemokine and cytokine response, neutrophile recruitment and activation, along with specific gene modules linked to LRTIs status and key blood markers. Moreover, LRTIs patients exhibited reduced diversity and evenness in the lower respiratory microbiome, likely driven by an increased abundance of bacterial pathogens. Host marker genes are selected, and classifiers are developed to distinguish patients with LRTIs, non-LRTIs, and indeterminate status, achieving an area under the receiver operating characteristic curve of 0.80 to 0.86 and validated in a subsequently enrolled cohort. Incorporating respiratory microbiome features further enhanced the classifier's performance. In summary, a single metatranscriptome test of BALF proved detailed profiles of host response and respiratory microbiome, enabling accurate LRTIs diagnosis.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2405087"},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Actuation-Mediated Compression of a Mechanoresponsive Hydrogel by Soft Robotics to Control Release of Therapeutic Proteins.
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202401744
Eimear J Wallace, Joanne O'Dwyer, Eimear B Dolan, Liam P Burke, Robert Wylie, Gabriella Bellavia, Stefania Straino, Francesca Cianfarani, Gabriella Ciotti, Simona Serini, Gabriella Calviello, Ellen T Roche, Tapas Mitra, Garry P Duffy
{"title":"Actuation-Mediated Compression of a Mechanoresponsive Hydrogel by Soft Robotics to Control Release of Therapeutic Proteins.","authors":"Eimear J Wallace, Joanne O'Dwyer, Eimear B Dolan, Liam P Burke, Robert Wylie, Gabriella Bellavia, Stefania Straino, Francesca Cianfarani, Gabriella Ciotti, Simona Serini, Gabriella Calviello, Ellen T Roche, Tapas Mitra, Garry P Duffy","doi":"10.1002/advs.202401744","DOIUrl":"https://doi.org/10.1002/advs.202401744","url":null,"abstract":"<p><p>Therapeutic proteins, the fastest growing class of pharmaceuticals, are subject to rapid proteolytic degradation in vivo, rendering them inactive. Sophisticated drug delivery systems that maintain protein stability, prolong therapeutic effects, and reduce administration frequency are urgently required. Herein, a mechanoresponsive hydrogel is developed contained within a soft robotic drug delivery (SRDD) device. In a step-change from previously reported systems, pneumatic actuation of this system releases the cationic therapeutic protein Vascular Endothelial Growth Factor (VEGF) in a bioactive form which is required for therapeutic angiogenesis, the growth of new blood vessels, in numerous clinical conditions. The ability of the SRDD device to release bioactive VEGF in a spatiotemporal manner from the hydrogel is tested in diabetic rats - a model in which angiogenesis is difficult to stimulate. Daily actuation of the SRDD device in the diabetic rat model significantly increased cluster of differentiation 31+ (CD31+) blood vessel number (p = 0.0335) and the diameter of alpha-smooth muscle actin+ (α-SMA+) blood vessels (p = 0.0025) compared to passive release of VEGF from non-actuated devices. The SRDD device combined with the mechanoresponsive hydrogel offers the potential to deliver an array of bioactive therapeutics in a spatiotemporal manner to mimic their natural release in vivo.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2401744"},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microfluidic Electrospinning Core-Shell Nanofibers for Anti-Corrosion Coatings With Efficient Self-Healing Properties. 微流体电纺丝核壳纳米纤维用于具有高效自愈合性能的防腐蚀涂层
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202409751
Qingqing Tang, Cuiping Ji, Guoying Wei, Jing Hu, Feifan Chang, Benfeng Zhu, Li Ren, Dongliang Peng
{"title":"Microfluidic Electrospinning Core-Shell Nanofibers for Anti-Corrosion Coatings With Efficient Self-Healing Properties.","authors":"Qingqing Tang, Cuiping Ji, Guoying Wei, Jing Hu, Feifan Chang, Benfeng Zhu, Li Ren, Dongliang Peng","doi":"10.1002/advs.202409751","DOIUrl":"https://doi.org/10.1002/advs.202409751","url":null,"abstract":"<p><p>Self-healing materials have been extensively explored in metal anti-corrosion fields. However, improving the self-healing efficiency remains a significant work that severely limits their further development. Here, a strategy to fabricate anti-corrosion coatings with efficient self-healing properties based on microfluidic electrospinning technologies and UV-curable healing agents is reported. The damaged composite coating contains core-shell nanofibers that can be completely healed within only 30 min, indicating an outstanding healing efficiency. The corrosion current density (I<sub>corr</sub>) of the composite coatings containing core-shell nanofibers (abbreviated as composite coatings) is lower than the coatings without any fibers (abbreviated as pure resin coatings) during the test of repeated damage and healing cycles, showing superior resistance to corrosion and repeated self-healing property. The composite coating has even better mechanical properties such as tensile strength, bending strength, and impact strength than the pure resin coating, which are explained by simulating the deformation process. These excellent properties greatly improve the practicability of self-healing coatings in the application of anti-corrosion, especially in some special fields.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2409751"},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nature's All-in-One: Multitasking Robots Inspired by Dung Beetles (Adv. Sci. 47/2024)
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202470287
Binggwong Leung, Stanislav Gorb, Poramate Manoonpong
{"title":"Nature's All-in-One: Multitasking Robots Inspired by Dung Beetles (Adv. Sci. 47/2024)","authors":"Binggwong Leung,&nbsp;Stanislav Gorb,&nbsp;Poramate Manoonpong","doi":"10.1002/advs.202470287","DOIUrl":"https://doi.org/10.1002/advs.202470287","url":null,"abstract":"<p><b>Multitasking Robots Inspired by Dung Beetles</b></p><p>Learning from nature can lead to groundbreaking robotics technology. In article number 2408080, Binggwong Leung, Stanislav Gorb, and Poramate Manoonpong draw inspiration from dung beetles' remarkable ability to transport large objects. They propose a neural control method that encodes this complex animal behavior for multitasking robots. This innovative approach can potentially revolutionize future missions in space exploration, search and rescue, construction, inspection, and agriculture. This neural control solution also provides a potential explanation of the intricate sensory-motor coordination involved in biological ball rolling by dung beetles.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"11 47","pages":""},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202470287","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Printing Untethered Self-Reconfigurable, Self-Amputating Soft Robots from Recyclable Self-Healing Fibers. 用可回收的自愈纤维打印出不受约束、可自我重构、自我输出的软体机器人。
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202410167
Yidan Gao, Wei Tang, Yiding Zhong, Xinyu Guo, Kecheng Qin, Yonghao Wang, Elena Yu Kramarenko, Jun Zou
{"title":"Printing Untethered Self-Reconfigurable, Self-Amputating Soft Robots from Recyclable Self-Healing Fibers.","authors":"Yidan Gao, Wei Tang, Yiding Zhong, Xinyu Guo, Kecheng Qin, Yonghao Wang, Elena Yu Kramarenko, Jun Zou","doi":"10.1002/advs.202410167","DOIUrl":"https://doi.org/10.1002/advs.202410167","url":null,"abstract":"<p><p>Regarding the challenge of self-reconfiguration and self-amputation of soft robots, existing studies mainly focus on modular soft robots and connection methods between modules. Different from these studies, this study focus on the behavior of individual soft robots from a material perspective. Here, a kind of soft fibers, which consist of hot melt adhesive particles, magnetizable microparticles, and ferroferric oxide microparticles embedded in a thermoplastic polyurethane matrix are proposed. The soft fibers can achieve wireless self-healing and reversible bonding of the fibers by eddy current heating and can be actuated by magnetic fields. Moreover, the soft fibers are recyclable and printable. Building on this material foundation, an integrated material-structure-actuation printing strategy using soft fibers for the design and fabrication of soft robots are reported. The robots printed by this strategy can achieve their untethered motions and wireless self-healing. Soft gripper, soft crawling robot, and soft multi-legged robot, are then fabricated which demonstrates the self-healing, self-reconfigurable, self-amputating, and sustainable performances of soft robots so as to adapt to different environments and tasks. This integrated material-structure-actuation printing strategy using soft fibers is universal, easy to implement, and mass-manufactured, opening a door for sustainable, eco-friendly, untethered, self-reconfigurable, self-amputating soft robots.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2410167"},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs-Mediated Mitochondrial Transfer (Adv. Sci. 47/2024)
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202470293
Xin He, Li Zhong, Nan Wang, Baiwei Zhao, Yannan Wang, Xinxiang Wu, Changyu Zheng, Yueheng Ruan, Jianfeng Hou, Yusheng Luo, Yuehan Yin, Yulong He, Andy Peng Xiang, Jiancheng Wang
{"title":"Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs-Mediated Mitochondrial Transfer (Adv. Sci. 47/2024)","authors":"Xin He,&nbsp;Li Zhong,&nbsp;Nan Wang,&nbsp;Baiwei Zhao,&nbsp;Yannan Wang,&nbsp;Xinxiang Wu,&nbsp;Changyu Zheng,&nbsp;Yueheng Ruan,&nbsp;Jianfeng Hou,&nbsp;Yusheng Luo,&nbsp;Yuehan Yin,&nbsp;Yulong He,&nbsp;Andy Peng Xiang,&nbsp;Jiancheng Wang","doi":"10.1002/advs.202470293","DOIUrl":"https://doi.org/10.1002/advs.202470293","url":null,"abstract":"<p><b>Gastric Cancer</b></p><p>The cover image shows Earth representing a gastric cancer (GC) cell, surrounded by multiple satellites symbolizing mesenchymal stromal cells (MSCs) in the tumor microenvironment. Numerous meteors, representing the chemotherapy drug oxaliplatin (OXA), are heading toward Earth. However, spacecraft from the satellites (mitochondrial transfer) create a protective shield, altering the path of the meteors and preventing the collision. This artwork vividly captures Yulong He, Andy Peng Xiang, Jiancheng Wang, and co-workers' discovery that mitochondrial transfer from MSCs to GC cells restores mitochondrial function, reduces mitophagy, and leads to OXA resistance. More details can be found in article number 2404994. The cover art was created by Coloring Guangzhou.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"11 47","pages":""},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202470293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain-Computer Interfaces Using Flexible Electronics: An a-IGZO Front-End for Active ECoG Electrodes.
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202408576
Kyle van Oosterhout, Ashley Chilundo, Mariana P Branco, Erik J Aarnoutse, Martijn Timmermans, Marco Fattori, Nick F Ramsey, Eugenio Cantatore
{"title":"Brain-Computer Interfaces Using Flexible Electronics: An a-IGZO Front-End for Active ECoG Electrodes.","authors":"Kyle van Oosterhout, Ashley Chilundo, Mariana P Branco, Erik J Aarnoutse, Martijn Timmermans, Marco Fattori, Nick F Ramsey, Eugenio Cantatore","doi":"10.1002/advs.202408576","DOIUrl":"https://doi.org/10.1002/advs.202408576","url":null,"abstract":"<p><p>Brain-computer interfaces (BCIs) are evolving toward higher electrode count and fully implantable solutions, which require extremely low power densities (<15mW cm<sup>-2</sup>). To achieve this target, and allow for a large and scalable number of channels, flexible electronics can be used as a multiplexing interface. This work introduces an active analog front-end fabricated with amorphous Indium-Gallium-Zinx-Oxide (a-IGZO) Thin-Film Transistors (TFTs) on foil capable of active matrix multiplexing. The circuit achieves only 70nV per sqrt(Hz) input referred noise, consuming 46µW, or 3.5mW cm<sup>-2</sup>. It demonstrates for the first time in literature a flexible front-end with a noise efficiency factor comparable with Silicon solutions (NEF = 9.8), which is more than 10X lower compared to previously reported flexible front-ends. These results have been achieved using a modified bootstrap-load amplifier. The front end is tested by playing through it recordings obtained from a conventional BCI system. A gesture classification based on the flexible front-end outputs achieves 94% accuracy. Using a flexible active front end can improve the state-of-the-art in high channel count BCI systems by lowering the multiplexer noise and enabling larger areas of the brain to be monitored while reducing power density. Therefore, this work enables a new generation of high channel-count active BCI electrode grids.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2408576"},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Na+,K+,2Cl- Cotransporter, Not Aquaporin 1, Sustains Cerebrospinal Fluid Secretion While Controlling Brain K+ Homeostasis.
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202409120
Dennis Bo Jensen, Trine L Toft-Bertelsen, Dagne Barbuskaite, Jane Stubbe, Sandor Nietzsche, Tenna Capion, Nicolas H Norager, Markus H Olsen, Andreas T Sørensen, Henrik Dimke, Christian A Hübner, Marianne Juhler, Nanna MacAulay
{"title":"The Na<sup>+</sup>,K<sup>+</sup>,2Cl<sup>-</sup> Cotransporter, Not Aquaporin 1, Sustains Cerebrospinal Fluid Secretion While Controlling Brain K<sup>+</sup> Homeostasis.","authors":"Dennis Bo Jensen, Trine L Toft-Bertelsen, Dagne Barbuskaite, Jane Stubbe, Sandor Nietzsche, Tenna Capion, Nicolas H Norager, Markus H Olsen, Andreas T Sørensen, Henrik Dimke, Christian A Hübner, Marianne Juhler, Nanna MacAulay","doi":"10.1002/advs.202409120","DOIUrl":"https://doi.org/10.1002/advs.202409120","url":null,"abstract":"<p><p>Disturbances in the brain fluid balance can lead to life-threatening elevation in intracranial pressure (ICP), which represents a vast clinical challenge. Targeted and efficient pharmaceutical therapy of elevated ICP is not currently available, as the molecular mechanisms governing cerebrospinal fluid (CSF) secretion are largely unresolved. To resolve the quantitative contribution of key choroid plexus transport proteins, this study employs mice with genetic knockout and/or viral choroid plexus-specific knockdown of aquaporin 1 (AQP1) and the Na<sup>+</sup>, K<sup>+</sup>, 2Cl<sup>-</sup> cotransporter 1 (NKCC1) for in vivo determinations of CSF dynamics, ex vivo choroid plexus for transporter-mediated clearance of a CSF K<sup>+</sup> load, and patient CSF for [K<sup>+</sup>] quantification. CSF secretion and ICP management occur independently of choroid plexus AQP1 expression, whereas both parameters are reduced by 40% upon choroid plexus NKCC1 knockdown. Elevation of [K<sup>+</sup>]<sub>CSF</sub> increases the choroid plexus Na<sup>+</sup>/K<sup>+</sup>-ATPase activity, and favors inwardly-directed net NKCC1 transport, which, together, promote CSF K<sup>+</sup> clearance, while maintaining undisturbed CSF secretion rates. CSF from patients with post-hemorrhagic hydrocephalus does not display elevated [K<sup>+</sup>]<sub>CSF</sub>, suggesting that NKCC1 maintains net outward transport direction during post-hemorrhagic hydrocephalus formation. Direct or indirect therapeutic modulation of choroid plexus NKCC1 can thus be a potential promising pharmacological approach against brain pathologies associated with elevated ICP.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2409120"},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Photothermal Nociceptor Using Mott Oscillators.
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2024-12-18 DOI: 10.1002/advs.202409353
Pyeongkang Hur, Daseob Yoon, Minwook Yoon, Yunkyu Park, Junwoo Son
{"title":"Artificial Photothermal Nociceptor Using Mott Oscillators.","authors":"Pyeongkang Hur, Daseob Yoon, Minwook Yoon, Yunkyu Park, Junwoo Son","doi":"10.1002/advs.202409353","DOIUrl":"https://doi.org/10.1002/advs.202409353","url":null,"abstract":"<p><p>Bioinspired sensory systems based on spike neural networks have received considerable attention in resolving high energy consumption and limited bandwidth in current sensory systems. To efficiently produce spike signals upon exposure to external stimuli, compact neuron devices are required for signal detection and their encoding into spikes in a single device. Herein, it is demonstrated that Mott oscillative spike neurons can integrate sensing and ceaseless spike generation in a compact form, which emulates the process of evoking photothermal sensing in the features of biological photothermal nociceptors. Interestingly, frequency-tunable and repetitive spikes are generated above the threshold value (P<sub>th</sub> = 84 mW cm<sup>-2</sup>) as a characteristic of \"threshold\" in leaky-integrate-and-fire (LIF) neurons; the neuron devices successfully mimic a crucial feature of biological thermal nociceptors, including modulation of frequency coding and startup latency depending on the intensity of photothermal stimuli. Furthermore, Mott spike neurons are self-adapted after sensitization upon exposure to high-intensity electromagnetic radiation, which can replicate allodynia and hyperalgesia in a biological sensory system. Thus, this study presents a unique approach to capturing and encoding environmental source data into spikes, enabling efficient sensing of environmental sources for the application of adaptive sensory systems.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2409353"},"PeriodicalIF":14.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carbon Nanocage-in-Microcage Structure With Tunable Carbon-Coated Nickel as a Microwave Absorber With Infrared Stealth Property.
IF 14.3 1区 材料科学
Advanced Science Pub Date : 2024-12-17 DOI: 10.1002/advs.202412890
Zhaoyang Li, Yang Xu, Lihong Wu, Yu Sun, Mingnan Zhang, Zhifeng Dou, Jinchuan Zhao, Yongzhu Yan, Guizhen Wang
{"title":"Carbon Nanocage-in-Microcage Structure With Tunable Carbon-Coated Nickel as a Microwave Absorber With Infrared Stealth Property.","authors":"Zhaoyang Li, Yang Xu, Lihong Wu, Yu Sun, Mingnan Zhang, Zhifeng Dou, Jinchuan Zhao, Yongzhu Yan, Guizhen Wang","doi":"10.1002/advs.202412890","DOIUrl":"https://doi.org/10.1002/advs.202412890","url":null,"abstract":"<p><p>The rational design of microwave absorption (MA) material featuring light weight, wide absorption bandwidth, and infrared stealth property is crucial for military stealth and health protection but remains challenging. Herein, an innovative N-doped carbon nanocage-in-microcage structure with tunable carbon-coated Ni (NC/Ni(HS)) is reported via a reliable Ni-catalyzed and Ni-templated method. The hierarchically hollow structure of nanocage-in-microcage composites can optimize the impedance matching and respond to multiple reflections and scattering of incident microwaves and infrared waves. Moreover, the magnetic Ni nanoparticles improve the synergistic interactions between confined heterointerfaces and promote interfacial polarization. Such an ingenious structure endows NC/Ni(HS) with outstanding MA performance and infrared stealth properties. Specifically, NC/Ni(HS)-10 with an optimal dielectric property, exhibits excellent MA performance. At an ultralow fill loading of 4 wt.%, a wide absorption bandwidth of 6.16 GHz is achieved at a thickness of 2.63 mm, and a strong reflection loss of -63.67 dB is obtained at a thickness of 2.00 mm. In addition, NC/Ni(HS)-10 shows a low infrared emissivity in the range of 3‒14 µm, which is the key to compatibility with infrared stealth. This work paves the way for the design of advanced MA materials that meet the requirements of multispectral-compatible stealth.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2412890"},"PeriodicalIF":14.3,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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