Advanced Science最新文献_第4页

IL-7R-Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation (Adv. Sci. 49/2026) 胸腺中富含il - 7r的细胞外囊泡通过促进中性粒细胞胞外陷阱的形成来驱动结肠炎（ad . Sci. 49/2026）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.77257

Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang

{"title":"IL-7R-Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation (Adv. Sci. 49/2026)","authors":"Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang","doi":"10.1002/advs.77257","DOIUrl":"https://doi.org/10.1002/advs.77257","url":null,"abstract":"Inflammatory Bowel DiseaseThis cover illustrates the thymus-gut axis in inflammatory bowel disease (IBD). Disorders in neutrophil extracellular trap (NET) formation can contribute to the development of IBD. During colitis, elevated circulating lipopolysaccharide stimulates the thymus to release IL-7R-enriched extracellular vesicles, which travel to the colon via the thymus-gut axis and promote NET formation in colonic tissues. Targeting this axis may offer novel therapeutic strategies for IBD management. More details can be found in the Research Article by Jie Wei, Yi Yang, Lifu Wang, and co-workers (DOI: 10.1002/advs.202520331).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 49","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.77257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148871903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterostructured Materials for Room-Temperature Na-S Batteries: Directional Design Strategies and Multifaceted Applications 室温钠硫电池异质结构材料：定向设计策略和多方面应用。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 Epub Date: 2026-08-06 DOI: 10.1002/advs.76019

Yeqing Yang, Xue Li, Kunjie Zhu, Xiang-Long Huang, Yun-Xiao Wang

{"title":"Heterostructured Materials for Room-Temperature Na-S Batteries: Directional Design Strategies and Multifaceted Applications","authors":"Yeqing Yang, Xue Li, Kunjie Zhu, Xiang-Long Huang, Yun-Xiao Wang","doi":"10.1002/advs.76019","DOIUrl":"10.1002/advs.76019","url":null,"abstract":"The development of room-temperature sodium-sulfur (RT Na-S) batteries is fundamentally constrained by many severe challenges, including the polysulfide shuttle effect, sluggish sulfur conversion kinetics, and unstable sodium metal anode. This comprehensive review systematically presents a universal and versatile materials design methodology, heterostructure engineering, to concurrently address these interlinked challenges. The electrochemical mechanisms of RT Na-S batteries based on different redox pathways are elaborated, with their corresponding key challenges. Followed by that, the multifunctional advantages and fundamental design principles of heterostructured materials are summarized. It is of greater importance that we pioneer to comprehensively elucidate various real applications of these tailored heterostructured materials in advanced RT Na-S batteries, involving host materials for sulfur and sodium, interface layer materials for sulfur cathode and sodium anode, solid-state electrolytes, and current collectors, etc. We conclude with critical perspectives on the unresolved scientific questions and practical hurdles, charting a pathway from laboratory-scale innovation to the realization of high-energy, long-cycle-life, and safe devices. By demonstrating how tailored heterointerfaces can regulate sulfur speciation, guide sodium electrodeposition, and accelerate reaction kinetics, this review establishes heterostructure engineering as a cornerstone for advancing RT Na-S batteries.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 49","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage-driven Inflammation” 修正“血管链球菌的细胞外囊泡通过上皮屏障破坏和巨噬细胞驱动的炎症介导胃炎”。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 Epub Date: 2026-08-06 DOI: 10.1002/advs.76534

引用次数: 0

RHINO: An Integrative Multi-Omics Framework Linking Circadian Physiology to Precision Medicine (Adv. Sci. 49/2026) RHINO：结合昼夜生理学与精准医学的整合多组学框架（Adv. Sci. 49/2026）

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.77254

Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López-Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan

{"title":"RHINO: An Integrative Multi-Omics Framework Linking Circadian Physiology to Precision Medicine (Adv. Sci. 49/2026)","authors":"Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López-Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan","doi":"10.1002/advs.77254","DOIUrl":"https://doi.org/10.1002/advs.77254","url":null,"abstract":"Rhythmic Interacting Network for Multi-OmicsCircadian rhythms shape human physiology, and their disruption influences disease risk and therapeutic response. However, the rhythmic and druggable genome remains largely unexplored. In their Research Article (DOI: 10.1002/advs.76371), Leng Han, Dongyin Guan, and co-workers present RHINO (RHythmic Interacting Network for multi-Omics), an AI-powered web portal that integrates ten multi-omic layers, disease, and drug-target data across tissues and species to expand the landscape of rhythmic therapeutic targets. On the cover, a luminous rhinoceros stands at the boundary of day and night, as warm and cool streams of circadian multi-omics data converge and crystallize across its honeycombed body. The artwork symbolizes RHINO as an integrated, living network attuned to the oscillations of the biological clock. Cover credit: Lan-Tao Gou (Shanghai BioPaint Studio).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 49","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.77254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148871902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micro/Nanoscale Acoustic Manipulation: From Particle Control to Autonomous Microswimmers. 微/纳米尺度声学操作：从粒子控制到自主微游泳者。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.77557

Jiahui Chu, Lemin Zhang, Xu Wang, Wenzong Li, Yahua Liu

{"title":"Micro/Nanoscale Acoustic Manipulation: From Particle Control to Autonomous Microswimmers.","authors":"Jiahui Chu, Lemin Zhang, Xu Wang, Wenzong Li, Yahua Liu","doi":"10.1002/advs.77557","DOIUrl":"10.1002/advs.77557","url":null,"abstract":"Acoustic manipulation and propulsion technologies have emerged as powerful platforms for micro/nanoscale control, enabled by their non-contact operation, label-free compatibility, biocompatibility, and strong penetration capability. This review systematically examines the physical mechanisms and recent advances in acoustically enabled passive particle manipulation and autonomous microswimmer propulsion. First, this article outlines the generation and propagation of acoustic waves and their fundamental interactions with matter, with emphasis on acoustic radiation forces and acoustic streaming. It then classifies representative device architectures and acoustic field modulation strategies based on bulk acoustic wave and surface acoustic wave systems. Building on this framework, recent progress in precise target manipulation across diverse media is synthesized, encompassing trapping, transport, enrichment, separation, and patterning. Furthermore, the review highlights the rapidly evolving field of acoustically driven microswimmers, analyzing autonomous propulsion mechanisms arising from shape- and density-induced asymmetries, cavitation phenomena, and sharp-edge oscillations, as well as recent advances in collective behavior, swarm coordination, and intelligent navigation. By delineating the developmental trajectory and key challenges of acoustic manipulation and propulsion, this review establishes a comprehensive knowledge framework for interdisciplinary researchers and highlights future opportunities in precision medicine, smart materials, micro/nano-fabrication, and cross-scale biological manipulation.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77557"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Mechanisms and Pathophysiological Significance of Insulin Resistance in Offspring With Intrauterine Growth Restriction Mediated by Hepatic GR/miR-1224 Programming” “肝脏GR/miR-1224编程介导的宫内生长受限子代胰岛素抵抗的机制和病理生理意义”的更正。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 Epub Date: 2026-08-05 DOI: 10.1002/advs.76952

引用次数: 0

Imperfect Oriented Attachment of Gold Nanoparticles. 金纳米颗粒的不完全定向附着。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.77335

Fangjie Meng, Peng Hu, Yongzhao Zhang, Gengshuo Zhang, Jiaqi Zhang, Ronghan Wei, Wen Wang, Shaobo Cheng

{"title":"Imperfect Oriented Attachment of Gold Nanoparticles.","authors":"Fangjie Meng, Peng Hu, Yongzhao Zhang, Gengshuo Zhang, Jiaqi Zhang, Ronghan Wei, Wen Wang, Shaobo Cheng","doi":"10.1002/advs.77335","DOIUrl":"10.1002/advs.77335","url":null,"abstract":"Particle coalescence is a fundamental pathway of nanoparticle growth, directly governing structural reconstruction, defect formation, and morphological evolution. However, the underlying driving forces behind imperfect oriented attachment, including what initiates the coalescence of misoriented crystals and determines the resulting structures remain unclear, particularly in liquid environments. This study combines in situ liquid-phase transmission electron microscopy with molecular dynamics calculations to investigate the coalescence dynamics of misoriented gold nanoparticles. Our findings reveal that misoriented nanoparticles can coalesce into a single crystal via a kinetically driven jump-to-coalescence process triggered by instantaneous hydration layer collapse. This coalescence is accompanied by a significant potential energy reduction, and the released energy enhances atomic mobility, particularly in small nanoparticles, enabling rapid structural rearrangement into a single crystal. Moreover, the initial contact position relative to the twin boundary determines the atomic diffusion pathway during the coalescence process of twin nanoparticles, while the twin boundary exhibits high stability during the merging process. These findings clarify the regulatory role of the kinetic factor in nanoparticle coalescence behavior and offer guidance for controlling crystal structure and designing twinned nanostructures in the liquid phase synthesis.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77335"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organic Nanozyme-Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression. 有机纳米酶包埋生物治疗热敏水凝胶用于细胞外谷胱甘肽消耗和术后肿瘤抑制。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.77309

Cong Jiang, Zifan Yang, Rong Guo, Meng Suo, Guowei Wang, Dong Chen, Lilin Su, Fuhuan Wang, Shipeng Ning, Kelong Fan, Xuan Wang

{"title":"Organic Nanozyme-Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression.","authors":"Cong Jiang, Zifan Yang, Rong Guo, Meng Suo, Guowei Wang, Dong Chen, Lilin Su, Fuhuan Wang, Shipeng Ning, Kelong Fan, Xuan Wang","doi":"10.1002/advs.77309","DOIUrl":"10.1002/advs.77309","url":null,"abstract":"Postoperative tumor recurrence remains a major challenge in solid tumor treatment, largely attributed to an immunosuppressive tumor microenvironment and the enrichment of extracellular glutathione (GSH) in the tumor bed, which supports tumor cell survival and proliferation. To address these issues, we designed a multifunctional hydrogel (named SEH) loaded with a novel cyanine nanozyme and Escherichia coli (E. coli). The cyanine nanozyme integrates efficient photothermal therapy (PTT), photodynamic therapy (PDT), and peroxidase-like enzyme activity. SEH is a temperature-sensitive agarose hydrogel. Upon light irradiation, PTT and PDT are simultaneously triggered, inducing hydrogel degradation to release the encapsulated nanozymes and E. coli. PTT and PDT jointly kill residual tumor cells and E. coli, and the death of the latter leads to the release of pathogen-associated molecular patterns (PAMPs). The nanozymes combined with PDT cyclically produce more reactive oxygen species to deplete extracellular GSH, which disrupts the redox balance of residual tumor cells. Furthermore, released PAMPs recruit immune cells to the tumor site, thereby activating anti-tumor immune responses and establishing long-term immune protection. This study provides a novel and effective strategy for postoperative tumor therapy and recurrence inhibition.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77309"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd-Immunity-on-a-Chip Platform. 利用微流控芯片上群体免疫平台解码结构群体中的病毒传播动力学。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 DOI: 10.1002/advs.77383

Jiande Zhang, Narina Jung, Min-Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park

{"title":"Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd-Immunity-on-a-Chip Platform.","authors":"Jiande Zhang, Narina Jung, Min-Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park","doi":"10.1002/advs.77383","DOIUrl":"10.1002/advs.77383","url":null,"abstract":"Understanding how population structure shapes viral transmission remains challenging because most in vitro models assume well-mixed conditions and lack spatial structure. We present a Herd-Immunity-on-a-Chip (HIC) platform-a 444-chamber microfluidic network that recreates structured populations-and apply it to human coronavirus 229E infecting MRC-5 fibroblasts. By varying initial inoculum (I0), susceptible density (S0), cell motility, and the fraction of non-susceptible cells (U0), we decode how seeding, density, immunity and movement reshape outbreak trajectories. Increasing S0 or I0 raised local contact rates, reduced effective intercellular spacing, and increased the reproduction number (R0), accelerating spread. In contrast, higher U0 suppressed transmission; with U0 ≥ 80% of the fixed uninfected population (S0 + U0), outbreaks collapsed (herd immunity). Independently, lowering S0 slowed early spread but did not, alone, prevent eventual transmission. We integrate the data with mathematical modelling of spatial, contact-structured transmission to quantify changes in R0 and apparent herd-immunity thresholds. HIC offers a generalizable, bench-top framework for outbreak forecasting and intervention testing.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77383"},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Multimodal Haptic Feedback Interface with Thin-Film Compliant Mechanism 一种具有薄膜柔性机构的多模态触觉反馈界面。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-09-03 Epub Date: 2026-07-08 DOI: 10.1002/advs.76412

Jingjing Wan, Emanuele Nicotra, James Davies, Kefan Zhu, Quang Anh Nguyen, Sinuo Zhao, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Hermione Truong, Patrick Pruscino, Tan Huynh, Phuoc Thien Phan, Hoang-Phuong Phan, Nigel Hamilton Lovell, Thanh Nho Do

{"title":"A Multimodal Haptic Feedback Interface with Thin-Film Compliant Mechanism","authors":"Jingjing Wan, Emanuele Nicotra, James Davies, Kefan Zhu, Quang Anh Nguyen, Sinuo Zhao, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Hermione Truong, Patrick Pruscino, Tan Huynh, Phuoc Thien Phan, Hoang-Phuong Phan, Nigel Hamilton Lovell, Thanh Nho Do","doi":"10.1002/advs.76412","DOIUrl":"10.1002/advs.76412","url":null,"abstract":"Multimodal cutaneous haptic interfaces can deliver multiple forms of mechanical stimulation and trigger different mechanoreceptors, enabling richer haptic information and realistic tactile sensations. Such interfaces have broad potential in healthcare, entertainment, and education. Electromagnetic (EM) actuators are particularly attractive for multimodal haptic systems due to their compact size, high controllability, and fast dynamic response. However, existing EM-based multimodal haptic devices struggle to simultaneously achieve large displacement, high output force, and effective constraint of unwanted degrees of freedom. To address this research gap, this paper presents a new thin-film compliant mechanism that exhibits high flexibility in translational motion along the X, Y, and Z axes while maintaining high stiffness against rotations about the X and Y axes. The new design enables the development of an electromagnetic multimodal haptic module capable of delivering indentation, stretch, and vibration stimuli, with the ability to superimpose vibration onto skin stretch. By integrating such two haptic modules into a wearable haptic array and employing a spatiotemporal encoding strategy, four-directional haptic cues can be effectively conveyed on hairy forearm skin, achieving a mean discrimination accuracy of 79.5%. Finally, a vision-guided human-in-the-loop haptic assistance system is implemented to demonstrate feasibility in assisting visually impaired users with daily tasks.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"13 49","pages":""},"PeriodicalIF":14.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13346363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148409764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0