Advanced Science最新文献_第4页

Acinar-Derived Organoids Reveal Stage-Specific Control of Acinar Plasticity. 腺泡衍生的类器官揭示了腺泡可塑性的阶段性控制。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78350

Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin

{"title":"Acinar-Derived Organoids Reveal Stage-Specific Control of Acinar Plasticity.","authors":"Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin","doi":"10.1002/advs.78350","DOIUrl":"10.1002/advs.78350","url":null,"abstract":"Adult pancreatic acinar cells undergo ordered metaplastic conversion during injury and tumor initiation. Whether individual cells retain redifferentiation capacity after metaplastic expansion, and what signals each transition requires, remains unknown. Here, using organoids derived from single acinar cells, we show that expanded acinar-lineage organoids can reacquire acinar features under stage-specific culture conditions. We defined conditions that preserve acinar identity ex vivo and showed that epidermal growth factor (EGF)/EGF receptor (EGFR) signaling initiates conversion from this maintained state. The expansion trajectory recapitulates injury- and oncogene-associated acinar-to-ductal metaplasia (ADM) programs in vivo. After expansion, the conditions that preserved acinar identity could not restore it; a staged regimen containing transient insulin-like growth factor 1 receptor (IGF1R) inhibition and dexamethasone promoted redifferentiation. The KrasG12D;Trp53R172H;Pdx1-Cre (KPC) genotype reduced EGFR dependence during initiation but destabilized post-expansion redifferentiation; Kras-pathway inhibition increased endpoint acinar-marker expression. These findings demonstrate that acinar plasticity is organized by stage-specific signals, and that the KPC genotype disrupts this control at specific transition points.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78350"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Foundation Model-Enabled Pathology-Informed MRI Model for Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Resectable Hepatocellular Carcinoma: A Multicenter Retrospective Study. 基于基础模型的病理信息MRI模型用于可切除肝细胞癌中血管包裹肿瘤簇的术前预测：一项多中心回顾性研究。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78135

Zhehan Shen, Wanmin Liu, Xiaoming Li, Wenjie Zou, Yiman Li, Jie Yuan, Yasen Yimit, Shihang Wang, Linhao Qu, Hui Dong, Wei Chen, Ningyang Jia, Peijun Wang

{"title":"Foundation Model-Enabled Pathology-Informed MRI Model for Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Resectable Hepatocellular Carcinoma: A Multicenter Retrospective Study.","authors":"Zhehan Shen, Wanmin Liu, Xiaoming Li, Wenjie Zou, Yiman Li, Jie Yuan, Yasen Yimit, Shihang Wang, Linhao Qu, Hui Dong, Wei Chen, Ningyang Jia, Peijun Wang","doi":"10.1002/advs.78135","DOIUrl":"10.1002/advs.78135","url":null,"abstract":"Vessels encapsulating tumor clusters (VETC) are an aggressive vascular phenotype of hepatocellular carcinoma that is usually determined after surgery. A foundation model-enabled framework for pathology-informed VETC prediction on pretreatment magnetic resonance imaging (MRI), termed PIVOT, uses paired preoperative multiparametric MRI, postoperative hematoxylin and eosin whole-slide images, and CD34 immunohistochemistry during model development, while inference requires only preoperative MRI. PIVOT-MRI uses morphologic and vascular embedding alignment, and PIVOT-Clinical combines the PIVOT-MRI score with tumor size and alpha-fetoprotein. The multicenter retrospective study includes 2052 patients in a training cohort, an internal test cohort, and four external validation cohorts. PIVOT-MRI achieves an area under the receiver operating characteristic curve of 0.887 in the internal test cohort and 0.839-0.861 across external cohorts. PIVOT-Clinical increases the internal-test area under the curve to 0.904 and PIVOT-Clinical-defined groups are associated with different two-year recurrence risks. Removing both histopathologic alignment branches results in the largest ablation-related performance decrease. Exploratory radiotranscriptomic analyses showed that higher PIVOT-MRI scores were associated with angiogenesis-related, endothelial, and proliferative transcriptional programs. PIVOT enables noninvasive preoperative assessment of pathology-defined vascular aggressiveness in resectable hepatocellular carcinoma while preserving an MRI-only clinical inference pathway.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78135"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent Photoluminescence Superlinearity Beyond Static Recombination Physics in Metal Halide Perovskites. 金属卤化物钙钛矿的持续光致发光超线性超越静态复合物理。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78378

Mehri Ghasemi, Qi Li, Baohua Jia, Xiaoming Wen

{"title":"Persistent Photoluminescence Superlinearity Beyond Static Recombination Physics in Metal Halide Perovskites.","authors":"Mehri Ghasemi, Qi Li, Baohua Jia, Xiaoming Wen","doi":"10.1002/advs.78378","DOIUrl":"10.1002/advs.78378","url":null,"abstract":"Persistent intermediate power-law exponent (β) values in metal halide perovskites commonly occur across excitation regimes in which assignment to a single carrier-population recombination limit becomes ambiguous. Their strong dependence on excitation conditions further indicates that excitation-dependent photoluminescence cannot always be interpreted uniquely through a static Shockley-Read-Hall (SRH)-bimolecular-Auger recombination picture. Here, power-dependent and time-resolved photoluminescence measurements on methylammonium lead iodide (MAPbI3, MA = CH3NH3) thin films reveal correlated evolution of excitation scaling, delayed emission, and illumination-history response under conditions that systematically modify vibrational dissipation and carrier-relaxation pathways. These behaviors are described using a dual-channel framework in which transient vibrational energy retention contributes to delayed radiative response. The results support an interpretation of PL superlinearity as an emergent, condition-dependent response associated with coupled carrier-lattice relaxation dynamics, rather than a simple transition between fixed recombination-order limits. More broadly, these results show that β and photoluminescence quantum yield (PLQY) should not be treated as fixed intrinsic material constants, but as excitation-conditioned observables shaped by the evolving relaxation environment, highlighting limitations in interpreting PL scaling laws as direct indicators of recombination pathways in soft semiconductors.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78378"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thioredoxin-2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation. 硫氧还蛋白-2通过抑制FOXO3a核易位缓解骨质疏松症。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78304

Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He

{"title":"Thioredoxin-2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation.","authors":"Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He","doi":"10.1002/advs.78304","DOIUrl":"10.1002/advs.78304","url":null,"abstract":"Osteoporosis is a prevalent age- and disease-associated skeletal disorder characterized by bone loss, remodeling imbalance, and vascular niche deterioration, yet how endothelial redox dysfunction drives this process remains unclear. Here, we identify mitochondrial thioredoxin-2 (TRX2) as an endothelial safeguard against osteoporotic bone loss. TRX2 was markedly reduced in aging bone vascular endothelial cells, and endothelial Trx2 deficiency accelerated skeletal degeneration by suppressing osteogenic activity and enhancing osteoclastogenesis. Mechanistically, TRX2 directly bound FOXO3a through a redox-sensitive Cys90-Cys31 disulfide interaction, retaining FOXO3a at the mitochondrial outer membrane and limiting its nuclear translocation. TRX2 loss or oxidative stress disrupted this complex, enabling FOXO3a-dependent transcriptional activation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and generating a pro-osteoclastogenic vascular niche. TRAIL neutralization or endothelial TRX2 restoration attenuated ovariectomy-induced osteoporosis by preserving angiogenic-osteogenic coupling. These findings establish the endothelial TRX2-FOXO3a-TRAIL axis as a vascular redox checkpoint and potential therapeutic target for osteoporosis.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78304"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astrocyte-Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis. 星形胶质细胞相关的ABCA1/APOE反应伴随癫痫发生期间海马脂质重塑和异位神经元积累。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78329

Lu Chen, Xiao-Rui Shi, Jia-Yi Chen, Ying-Ting Wang, Le Du, Yang Ni, Jun-Min Chen, An-Chen Guo, Qian Wu, Jian-Ping Wu, Qun Wang

{"title":"Astrocyte-Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis.","authors":"Lu Chen, Xiao-Rui Shi, Jia-Yi Chen, Ying-Ting Wang, Le Du, Yang Ni, Jun-Min Chen, An-Chen Guo, Qian Wu, Jian-Ping Wu, Qun Wang","doi":"10.1002/advs.78329","DOIUrl":"10.1002/advs.78329","url":null,"abstract":"Temporal lobe epilepsy (TLE) is characterized by progressive hippocampal remodeling, including reactive astrogliosis and aberrant neuronal positioning. Although lipid disturbances are implicated in epileptogenesis, how astrocyte-associated lipid responses relate to hippocampal remodeling remains poorly understood. Here, human TLE and kainic acid (KA)-treated mouse transcriptomic datasets identified ATP-binding cassette transporter A1 (ABCA1)/Abca1 as a nominal astrocyte-associated candidate, while KA- and pilocarpine-induced status epilepticus (SE) elicited astrocyte-associated ABCA1/apolipoprotein E (APOE) responses. Ectopic granule cells and immature neurons accumulated in the hilus and were spatially associated with ABCA1-positive cells, including astrocytic profiles; perilipin 2 (PLIN2)-positive puncta were nearby. Pretreatment with the retinoid X receptor (RXR) agonist bexarotene increased hippocampal ABCA1 expression, delayed severe KA-induced behavioral seizure onset, and was associated with fewer chronic spontaneous seizures and reduced ectopic neuronal accumulation. Post-SE bexarotene administration was associated with lower seizure frequency, ectopic neuronal accumulation, and astrocytic marker-positive cell densities. Multi-omic profiling identified bexarotene-associated metabolic and lipidomic changes; transmission electron microscopy (TEM) showed a smaller mean hilar neuronal lipid-droplet area per image, and protein analyses identified early changes in p38 and extracellular signal-regulated kinase 1/2 (Erk1/2) phosphorylation. Together, these findings warrant further investigation of astrocyte-associated lipid pathways as potential therapeutic targets in epilepsy-associated hippocampal remodeling.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78329"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intelligent Field-Adaptive Electrohydrodynamic Printing for Curved Conformal Electronics. 曲面保形电子的智能场自适应电液动力打印。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78343

Chang Liu, Yiwen Feng, Xu Chen, Kaiwen Chen, Ran Zhang, Xiaopeng Zhang, Liujia Suo, Xiangji Chen, Zefei Li, Fengshu Wang, Ruixuan Xu, Shuaiwu Liu, Shiwen Liang, Lingjie Kong, Dazhi Wang

{"title":"Intelligent Field-Adaptive Electrohydrodynamic Printing for Curved Conformal Electronics.","authors":"Chang Liu, Yiwen Feng, Xu Chen, Kaiwen Chen, Ran Zhang, Xiaopeng Zhang, Liujia Suo, Xiangji Chen, Zefei Li, Fengshu Wang, Ruixuan Xu, Shuaiwu Liu, Shiwen Liang, Lingjie Kong, Dazhi Wang","doi":"10.1002/advs.78343","DOIUrl":"10.1002/advs.78343","url":null,"abstract":"Curved conformal electronics are increasingly important for wearable devices, biosensing, and advanced communication systems, requiring high-resolution and high-precision manufacturing on complex surfaces. Electrohydrodynamic printing is a promising method for fabricating conformal electronics, but its application on curved insulating substrates is hindered by local electric-field disturbances arising from residual charge accumulation and spatial variations, leading to poor dimensional control. To address this challenge, an intelligent field-adaptive electrohydrodynamic printing framework is established, in which alternating-electric-field modulation reduces the effects of residual charge, the equivalent electrical gap quantitatively characterizes spatially varying electric-field conditions, and machine learning-based parameter regulation compensates for local electric-field variations. Based on this framework, a machine-learning and alternating-electric-field synergistic modulated electrohydrodynamic printing approach is developed to achieve stable printing and precise line-width control on curved substrates. The approach rapidly optimizes parameters for target line widths, achieving average relative errors around 10% or lower at the initial printing position, and further reduces average relative line-width errors by up to 7.24 percentage points through adaptive regulation during curved-substrate printing. Diverse high-precision patterns are printed, and the conformal frequency-selective surface and antenna with excellent electromagnetic performance are fabricated, demonstrating the potential of this framework for advancing curved conformal electronics manufacturing.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78343"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI-EXAFS: Physics-Informed Prediction of EXAFS from Atomic Structure. AI-EXAFS：基于原子结构的EXAFS物理预测。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78226

Javier Heras-Domingo, Andrea Ruiz-Ferrando, Adam H Clark, Stephan Pollitt, Sharon Mitchell, Javier Pérez-Ramírez, Núria López

{"title":"AI-EXAFS: Physics-Informed Prediction of EXAFS from Atomic Structure.","authors":"Javier Heras-Domingo, Andrea Ruiz-Ferrando, Adam H Clark, Stephan Pollitt, Sharon Mitchell, Javier Pérez-Ramírez, Núria López","doi":"10.1002/advs.78226","DOIUrl":"10.1002/advs.78226","url":null,"abstract":"Understanding atomic structure across chemical systems relies heavily on extended X-ray absorption fine structure (EXAFS) because of its sensitivity to local atomic environments. However, quantitative interpretation remains inherently iterative, requiring structural parameters or models to be fitted against experimental spectra using explicit multiple-scattering calculations. Machine-learning approaches have accelerated EXAFS analysis, yet direct prediction of full spectra from atomistic structure across diverse chemical environments remains challenging. Here, we introduce AI-EXAFS, a physics-informed graph neural network that predicts spectra directly from three-dimensional atomic coordinates. Combining an absorber-centered graph representation with distance-modulated message passing and an EXAFS-specific training objective enables direct learning of structure-spectrum relationships without predefined structural descriptors or manual parameter selection. Trained and evaluated across a dataset of 85,991 transition-metal complexes with FEFF-generated spectra, AI-EXAFS achieves average held-out test-set R-factors of 0.043 in <math><mi>k</mi></math> -space and 0.019 in <math><mi>R</mi></math> -space, demonstrating accurate structure-to-spectrum prediction across a broad range of local chemical environments. AI-EXAFS establishes a scalable structure-to-spectrum framework for EXAFS, enabling direct inference across large sets of candidate structures and providing a foundation for data-driven prediction across increasingly complex and experimentally relevant environments.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78226"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HECTD1 Directs HIF-1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis. hecd1通过促进Th17分化和糖酵解介导HIF-1α促进肠道炎症和癌变。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78339

Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao

{"title":"HECTD1 Directs HIF-1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis.","authors":"Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao","doi":"10.1002/advs.78339","DOIUrl":"10.1002/advs.78339","url":null,"abstract":"Targeting glucose metabolism in Th17 cells may be beneficial for treating inflammatory bowel disease (IBD) and colitis-associated cancer (CAC), however, the molecular mechanisms orchestrating Th17 cell metabolism remain unclear. Here, we revealed that HECTD1 regulates IGF2BP3-dependent HIF-1α translation to promote Th17 cell glycolysis and differentiation and that HECTD1 expression correlates with IBD and CAC pathogenesis. T-cell-specific deletion of HECTD1 mitigated the severity of colitis and CAC in murine models. RNA-seq revealed enrichment of Th17 differentiation, glycolysis/gluconeogenesis, and HIF-1 signaling pathways among differentially expressed genes between HECTD1-sufficient and HECTD1-deficient CD4+ T cells. Consistently, loss of HECTD1 suppressed Th17 cell differentiation both in vitro and in vivo, and suppressed glycolytic metabolism and HIF-1α activity, revealing the mechanism underlying its protective effects against IBD and CAC. Mechanistically, HECTD1 potentiates m6A-based HIF-1α translation by mediating IGF2BP3 K63-linked ubiquitination to promote the binding of IGF2BP3 with the translation initiation machinery of Hif1a mRNA. Reciprocally, HIF-1α acts as a key transcription factor that promotes Hectd1 gene expression, establishing a distinct positive feedback loop. Our findings highlight a self-reinforcing feedback mechanism in which HECTD1 and HIF-1α engage in mutual regulation to dictate Th17 cell fate and metabolic reprogramming, providing novel potential IBD and CAC treatments targeting HECTD1.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78339"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

H-Bonding-Induced Repulsion Between Small Groups Toward a Highly Puckered Benzene. 氢键诱导的小基团间对高度起皱苯的斥力。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78352

Chaofeng Zhao, Qi Sun, Ning Ding, Xiaoting Ren, Jinxuan He, Shenghua Li, Siping Pang

引用次数: 0

CeO₂-Based Electrocatalysts for the Oxygen Evolution Reaction: Design, Dynamic Mechanisms, and Electrolyte Adaptability. 基于ceo2的析氧反应电催化剂：设计、动力学机制和电解质适应性。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78316

Zhen Cui, Ailing Song, Zirui Cui, Manman Duanmu, Zhipeng Ma, Hao Liu, Guangjie Shao, Xinyi Tan, Guoxiu Wang, Hao Tian

{"title":"CeO2-Based Electrocatalysts for the Oxygen Evolution Reaction: Design, Dynamic Mechanisms, and Electrolyte Adaptability.","authors":"Zhen Cui, Ailing Song, Zirui Cui, Manman Duanmu, Zhipeng Ma, Hao Liu, Guangjie Shao, Xinyi Tan, Guoxiu Wang, Hao Tian","doi":"10.1002/advs.78316","DOIUrl":"10.1002/advs.78316","url":null,"abstract":"CeO2-based electrocatalysts are promising for the oxygen evolution reaction (OER) owing to their distinctive Ce3+/Ce4+ redox flexibility, large oxygen-storage capacity, and lattice adaptability. More importantly, CeO2 can dynamically regulate catalyst surface reconstruction and electronic structure while significantly enhancing catalytic activity and long-term stability. In this review, we first focus on CeO2-based electrocatalysts for OER from structural characteristics, design principles and strategies, structure-property relationships, interfacial structure, as well as critical evaluation of design strategies and selection principles. The mechanistic roles of CeO2 in OER are highlighted, including redox chemistry and oxygen-vacancy (Ov) dynamics, electronic-structure modulation and charge transfer, interfacial coupling and surface reconstruction, as well as operando evidence and the controversy over lattice-oxygen participation. The performance of CeO2-based OER electrocatalysts in different electrolytes, including alkaline, acidic, and seawater media, is also summarized to demonstrate their applicability under diverse operating conditions. Finally, from the perspectives of electronic-structure evolution, redox-state transitions, lattice evolution, and catalytic pathways, this review summarizes the underlying mechanisms by which CeO2 regulates the dynamic catalytic behavior of OER and provides an outlook on future design strategies for developing highly efficient and durable CeO2-based electrocatalysts.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78316"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0