Advanced Science最新文献_第4页

High Electron Charge Carrier Mobility in the Nematic Phase of a Roof-Shaped Nematogen with Optimum Molecular Biaxiality. 具有最佳分子双轴性的屋顶状线虫的向列相中高载流子迁移率。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202510009

Matthias Lehmann, Nikolai Scheuring, Loïc Mager, Dharmendra Pratap Singh, Richard Mandle, Alexey Eremin

引用次数: 0

Observation of Magnetic Pseudogap Behavior in Phosphorus-Doped Silicon. 掺磷硅中磁赝隙行为的观察。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202502789

Suheon Lee, Sangeun Cho, Yongcheol Jo, Wonjun Lee, Jae Min Kim, Hong Gu Lee, Yugo Oshima, Taku Matsushita, Hiroki Ikegami, Jonas A Krieger, Christoper Baines, Thomas J Hicken, Hubertus Luetkens, Eundeok Mun, Jungseek Hwang, Hyunsik Im, Kwang-Yong Choi

{"title":"Observation of Magnetic Pseudogap Behavior in Phosphorus-Doped Silicon.","authors":"Suheon Lee, Sangeun Cho, Yongcheol Jo, Wonjun Lee, Jae Min Kim, Hong Gu Lee, Yugo Oshima, Taku Matsushita, Hiroki Ikegami, Jonas A Krieger, Christoper Baines, Thomas J Hicken, Hubertus Luetkens, Eundeok Mun, Jungseek Hwang, Hyunsik Im, Kwang-Yong Choi","doi":"10.1002/advs.202502789","DOIUrl":"https://doi.org/10.1002/advs.202502789","url":null,"abstract":"The recent discovery of a Kondo condensate in phosphorus-doped silicon (Si:P) presents its significant potential for achieving novel many-body quantum states. Si:P exhibits Kondo condensation, characterized by an energy gap in the electronic density of states, while the precise nature of its magnetic state has yet to be determined. Here, we utilize electron and muon spin resonance (ESR and µSR) techniques, optical spectroscopy, and specific heat measurements to unravel the magnetic ground state and spin dynamics of Si:P. Both optical and ESR spectroscopy reveal the onset of spin correlations below 150 K. Furthermore, the muon spin relaxation rate exhibits a power-law increase, λZF∼T-0.26(5), below TKC ≈ 0.2 K, indicating the emergence of critical spin fluctuations within the Kondo condensate state. Strikingly, the concomitant occurrence of a Bardeen-Cooper-Schrieffer-like charge gap and power-law magnetic fluctuations closely parallels the pseudogap phases observed in doped Mott insulators. These findings evince that the critical spin fluctuations of the Kondo condensate state act as a driving force for pseudogap formation within inhomogeneous Kondo clouds.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e02789"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing Biomaterial-Based mRNA Delivery System for Lung Disease Treatment. 基于生物材料的肺疾病mRNA传递系统的研究

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202505413

Qiancheng Gu, Huaqian Xue, Zhiyun Liu, Jiameng Rao, Lingyao Zeng, Chen Zhang, Lanjie Lei, Liyun Shi

{"title":"Developing Biomaterial-Based mRNA Delivery System for Lung Disease Treatment.","authors":"Qiancheng Gu, Huaqian Xue, Zhiyun Liu, Jiameng Rao, Lingyao Zeng, Chen Zhang, Lanjie Lei, Liyun Shi","doi":"10.1002/advs.202505413","DOIUrl":"https://doi.org/10.1002/advs.202505413","url":null,"abstract":"Lung disease remains a persistent global health challenge. Advances in medical research have led to innovative strategies to combat these conditions, with biomaterials emerging as a promising platform for targeted drug delivery. Various biomaterials-including nanoparticles such as liposomes, polymers, hybrid systems, dendritic polymers, gold nanoparticles, mesoporous silica, calcium carbonate, and exosomes-exhibit excellent biocompatibility. These materials protect therapeutic agents from nuclease degradation, stabilize drug carriers, and enhance cellular uptake via mechanisms such as endocytosis. Chemical modifications further improve biomaterials by facilitating endosomal escape and conjugation with targeting ligands, thereby enabling precise delivery to specific cells or tissues. As a therapeutic modality, mRNA offers high biosafety, notable controllability, efficient translation, and immunomodulatory properties. This review evaluates the impact of lung structure on drug absorption, examines delivery mechanisms associated with various biomaterial types, and presents application examples. It also summarizes recent research developments, discusses clinical limitations, and explores future research directions for biomaterials in lung disease therapy. Additionally, it highlights the role of biomaterials in stabilizing and protecting mRNA, providing insights into the advancement of mRNA-based therapeutics. This review aims to establish a robust theoretical foundation and offer practical guidance for biomaterial-based mRNA therapies in treating lung diseases.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e05413"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to ""Cicada Out of the Shell" Deep Penetration and Blockage of the HSP90 Pathway by ROS-Responsive Supramolecular Gels to Augment Trimodal Synergistic Therapy". “破壳蝉”ros反应性超分子凝胶深度穿透和阻断HSP90通路以增强三模态协同治疗”的更正。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202512868

引用次数: 0

A Human Immuno-Lung Organoid Model to Study Macrophage-Mediated Lung Cell Senescence Upon SARS-CoV-2 Infection. 研究SARS-CoV-2感染后巨噬细胞介导的肺细胞衰老的人免疫-肺类器官模型

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202503932

Yuling Han, Dongliang Leng, Tuo Zhang, Jian Ge, Yinshan Fang, Tiankun Lu, Xue Dong, Manoj S Nair, Neranjan de Silva, Zhaowei Han, Tiancheng Jiao, Yuanhao Huang, Meiqi Zhao, Anjali Saqi, Hanina Hibshoosh, Zihe Meng, Jenny Z Xiang, Chendong Pan, Yanjie Sun, David D Ho, Todd Evans, Jie Liu, Liuliu Yang, Jianwen Que, Shuibing Chen

{"title":"A Human Immuno-Lung Organoid Model to Study Macrophage-Mediated Lung Cell Senescence Upon SARS-CoV-2 Infection.","authors":"Yuling Han, Dongliang Leng, Tuo Zhang, Jian Ge, Yinshan Fang, Tiankun Lu, Xue Dong, Manoj S Nair, Neranjan de Silva, Zhaowei Han, Tiancheng Jiao, Yuanhao Huang, Meiqi Zhao, Anjali Saqi, Hanina Hibshoosh, Zihe Meng, Jenny Z Xiang, Chendong Pan, Yanjie Sun, David D Ho, Todd Evans, Jie Liu, Liuliu Yang, Jianwen Que, Shuibing Chen","doi":"10.1002/advs.202503932","DOIUrl":"https://doi.org/10.1002/advs.202503932","url":null,"abstract":"While COVID-19 affects multiple organ systems, the human respiratory system is the primary viral target and main site for disease progression. In this study, spatial transcriptional assays (NanoString CosMx) are utilized to analyze both explant and autopsy samples from non-COVID and COVID-19 lungs, identifying the activation of proinflammatory macrophages in COVID-19 explants. It is further developed immuno-lung organoids comprising hPSC-derived alveolar and airway organoids co-cultured with macrophages to investigate the impact and underlying mechanisms of macrophage-mediated lung damage following SARS-CoV-2 infection. The findings demonstrate that proinflammatory macrophages induce lung cell senescence through the THBS1-(ITGA3+ITGB1) signaling axis, a mechanism further validated using spatial transcriptomics. This study not only establishes physiologically relevant immuno-lung organoid models for modeling macrophage-mediated tissue damage, but also identifies a previous unrecognized role of the THBS1-(ITGA3+ITGB1) pathway in driving lung cell senescence during infectious disease.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e03932"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing z Spin Generation in Trivial Spin Hall Materials for Scalable, Energy-Efficient, Field-Free, Complete Spin-Orbit Torque Switching Applications. 在可扩展、高能效、无场、完全自旋-轨道转矩开关应用中增强平凡自旋霍尔材料中的z自旋产生。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-25 DOI: 10.1002/advs.202507581

Qianbiao Liu, Lijun Zhu

{"title":"Enhancing z Spin Generation in Trivial Spin Hall Materials for Scalable, Energy-Efficient, Field-Free, Complete Spin-Orbit Torque Switching Applications.","authors":"Qianbiao Liu, Lijun Zhu","doi":"10.1002/advs.202507581","DOIUrl":"https://doi.org/10.1002/advs.202507581","url":null,"abstract":"Despite the remarkable efforts in the past two decades, it has remained a major challenge to achieve switching of perpendicularly magnetized spin-orbit torque devices in a scalable, energy-efficient, field-free, integration-friendly, and complete manner. Here, a giant enhancement of z spin generation in low-resistivity spin Hall metal/FeCoB devices is reported by alloying the spin Hall metal Pt with Ti and by electric asymmetry engineering. The damping-like spin torques of z spins and y spins are enhanced by 6 and 3 times relative to those of conventional Pt/FeCoB and enable complete, record-low-power, deterministic switching of FeCoB devices with strong perpendicular magnetic anisotropy and high coercivity. The Pt75Ti25/FeCoB heterostructure also exhibits relatively low resistivity, wafer-scale uniform sputterdeposition on silicon oxide, good compatibility with magnetic tunnel junctions, and excellent thermal stability of exceeding 400 °C. These results unambiguously establish the Pt75Ti25/FeCoB as the most compelling candidate for solving the bottleneck of scalable, energy-efficient, field-free, integration-friendly, and complete spin-orbit torque switching technologies. This work also provides a universal strategy for developing high-performance generators of z-spin current and will stimulate the exploration of exotic spin currents by alloying \"trivial\" spin Hall materials.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e07581"},"PeriodicalIF":14.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical Role of IL1R2-ENO1 Interaction in Inhibiting Glycolysis-Mediated Pyroptosis for Protection Against Lethal Sepsis. IL1R2-ENO1相互作用在抑制糖酵解介导的焦亡保护致死性败血症中的关键作用。

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-24 DOI: 10.1002/advs.202502297

Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang

{"title":"Critical Role of IL1R2-ENO1 Interaction in Inhibiting Glycolysis-Mediated Pyroptosis for Protection Against Lethal Sepsis.","authors":"Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang","doi":"10.1002/advs.202502297","DOIUrl":"https://doi.org/10.1002/advs.202502297","url":null,"abstract":"Immune cell metabolic reprogramming toward glycolysis is vital for sepsis defense. While interleukin 1 receptor 2 (IL1R2) acts as a decoy receptor for IL1α/β, its potential impact on cell metabolism and death during sepsis remains unclear. This study observed elevated plasma soluble IL1R2 (sIL1R2) levels in septic patients and mice. In pyroptotic macrophages, reduced intracellular IL1R2 expression led to its release extracellularly. Proteomic screening identified enolase 1 (ENO1), a key glycolysis enzyme, as the binding partner of IL1R2 in macrophages. IL1R2 suppresses ENO1 activity to inhibit glycolysis, gasdermin D (GSDMD)-mediated pyroptosis, and inflammation in macrophages. IL1R2-deficient mice exhibited heightened susceptibility to sepsis, with increased inflammation, organ injury, and mortality. Notably, ENO1 inhibition reduced inflammation, organ injury, and improved survival rates in septic mice. The study reveals that IL1R2 interacts with ENO1 to inhibit glycolysis-mediated pyroptosis and inflammation in sepsis, suggesting the IL1R2-ENO1 interaction as a promising therapeutic target of sepsis.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e02297"},"PeriodicalIF":14.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid Solar Spectral-Splitting Photovoltaic-Thermal Hydrogen Production Systems (Adv. Sci. 28/2025) 混合太阳能分光光热制氢系统（ads . Sci. 28/2025）

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-24 DOI: 10.1002/advs.202570216

Yu Tian, Pooria Hadikhani, Nada Alati, Bryce S. Richards, Gan Huang

引用次数: 0

Photo-Rechargeable Organic Supercapacitor via Light-Activated Electrolytes (Adv. Sci. 28/2025) 基于光活化电解质的光可充电有机超级电容器（Adv. Sci. 28/2025）

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-24 DOI: 10.1002/advs.202570225

Shubhra Kanti Bhaumik, Sudipta Biswas, Nitzan Shauloff, Ahiud Morag, Raz Jelinek

引用次数: 0

Potential-Driven Dynamic Spring-Effect of Pd─Cu Dual-Atoms Empowered Stability and Activity for Electrocatalytic Reduction (Adv. Sci. 28/2025) 电位驱动的Pd─Cu双原子动态弹簧效应增强电催化还原的稳定性和活性（Sci. 28/2025）

IF 14.3 1区材料科学

Advanced Science Pub Date : 2025-07-24 DOI: 10.1002/advs.202570222

Pei-Hua Li, Yuan-Fan Yang, Zong-Yin Song, Bo Liang, Yong-Huan Zhao, Xin Cai, Zi-Hao Liu, Jing-Yi Lin, Meng Yang, Xiangyu Xiao, Jing Zhang, Wen-Qing Liu, Xing-Jiu Huang

引用次数: 0