Advanced Science最新文献_第5页

A Chiral Virus-Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy. 一种手性病毒样纳米平台广泛介导抗生素向脑的传递，用于细菌性脑膜炎治疗。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78317

Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu

{"title":"A Chiral Virus-Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy.","authors":"Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu","doi":"10.1002/advs.78317","DOIUrl":"10.1002/advs.78317","url":null,"abstract":"Blood-brain barrier (BBB) preserves brain homeostasis yet restricts therapeutics; in bacterial meningitis, antibiotics' limited penetration impairs delivery to the parenchyma and cerebrospinal fluid, constraining efficacy and motivating strategies to overcome the barrier. To address this, we developed a chiral virus-mimicking mesoporous silica nanostructure (CVSN) functionalized with L-alanine for antibiotic delivery. It offers several distinct advantages: (1) nanoscale dimensions facilitating BBB transport; (2) virus-like morphology enhancing vascular accumulation and penetration, providing a foundation for passive targeting; (3) chiral surface modification conferring active recognition capacity for more efficient biological targeting; and (4) a mesoporous architecture that ensures high drug-loading efficiency and controlled release of drugs. Experimentally, it achieves efficient BBB penetration into the brain parenchyma and shows targeted delivery into microglia and astrocytes. Simulating the loading of cargoes by viruses, it ultimately improves the bioavailability and brain parenchyma and cerebrospinal fluid contents of various antibiotics with distinct physicochemical properties, antibacterial spectrum, and BBB penetration capacity, including cefoperazone, norfloxacin, levofloxacin and imipenem. It helps to treat meningitis induced by both Gram-negative bacteria (e.g., Escherichia coli) and Gram-positive bacteria (e.g., Staphylococcus aureus) and provides a promising avenue to overcome the limitations imposed by the BBB for CNS infections antibiotic therapy in clinic.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78317"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physics-Guided Multi-Channel Restoration for Efficient and Accurate Atomic Force Microscopy Imaging. 物理引导的多通道恢复高效和准确的原子力显微镜成像。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78289

Jaeuk Sung, Hongseok Kim, Seungjae Heo, Jin Tae Moon, Jangwoo Ko, Panithan Sriboriboon, Dong-Gyu Lee, Sanghyun Jo, Hee Han, Jungho Ryu, Woo Lee, Jinseong Heo, Hyun-Cheol Song, Yunseok Kim

{"title":"Physics-Guided Multi-Channel Restoration for Efficient and Accurate Atomic Force Microscopy Imaging.","authors":"Jaeuk Sung, Hongseok Kim, Seungjae Heo, Jin Tae Moon, Jangwoo Ko, Panithan Sriboriboon, Dong-Gyu Lee, Sanghyun Jo, Hee Han, Jungho Ryu, Woo Lee, Jinseong Heo, Hyun-Cheol Song, Yunseok Kim","doi":"10.1002/advs.78289","DOIUrl":"10.1002/advs.78289","url":null,"abstract":"Scientific imaging instruments often acquire multiple physically complementary signals within a single measurement. In atomic force microscopy (AFM), high-throughput imaging requires higher scan speeds, however, image quality is fundamentally limited by multiple distortions. These artifacts are further amplified for sharp nano/microstructures, making accurate image restoration inherently challenging. Most deep learning-based approaches rely on a single primary channel and improve performance by increasing model complexity or training data. Here, we introduce a physics-guided multi-channel input approach for AFM that utilizes co-acquired auxiliary signals to improve image restoration efficiency and accuracy. We construct a four co-acquired channel input, each containing complementary physical information. By integrating these channels into a lightweight convolutional neural network, the proposed approach significantly improves restoration quality with minimal additional parameters. At a scan rate of 7.0 Hz, the four-channel DnCNN achieved higher reconstruction accuracy than a single-channel Restormer with approximately 47 times as many parameters, while providing approximately 24 times faster inference. Across the evaluated EFM and PFM conditions, four-channel inputs reduced the training-patch requirement by approximately two to three times at matched PSNR.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78289"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To Be or Not to Be Eutectic: Anomalous Glass Forming Ability Governed by Melt Structural Complexity. 是否共晶：由熔体结构复杂性决定的反常玻璃形成能力。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78359

Wei Chen, Xuerui Wei, Chengzhe Wang, Zhichao Lu, Fan Zhang, Yan Huang, Yibo Zhang, Liang Wang, Saichao Cao, Chunyin Zhou, Ke Yang, Zhendong Fu, Jinkui Zhao, Dongbai Sun, Fanqiang Meng, Zhou Zhou, Xun-Li Wang, Weihua Wang, Dong Ma

{"title":"To Be or Not to Be Eutectic: Anomalous Glass Forming Ability Governed by Melt Structural Complexity.","authors":"Wei Chen, Xuerui Wei, Chengzhe Wang, Zhichao Lu, Fan Zhang, Yan Huang, Yibo Zhang, Liang Wang, Saichao Cao, Chunyin Zhou, Ke Yang, Zhendong Fu, Jinkui Zhao, Dongbai Sun, Fanqiang Meng, Zhou Zhou, Xun-Li Wang, Weihua Wang, Dong Ma","doi":"10.1002/advs.78359","DOIUrl":"10.1002/advs.78359","url":null,"abstract":"For decades, the search for metallic glass formers has followed a simple rule: go for the eutectics. However, this conventional wisdom has been challenged by a lingering mystery-certain congruent melting alloys exhibit higher glass-forming ability (GFA) than their eutectic neighbors. Here, we unravel this anomaly by probing the structure of high-temperature melt-the direct precursor to a glass. Using Ti-Cu as a model system, we conduct a comparative study on a eutectic Ti27Cu73 and its congruent melting counterpart Ti50Cu50. By combining aerodynamic levitation, in situ synchrotron x‑ray diffraction, and an energy minimization-enhanced reverse Monte Carlo method, we resolve the atomic structures of these alloys in both the melt and glassy states. We reveal that the congruent melt is structurally more complex than the eutectic, exhibiting higher cluster diversity and stronger inter‑cluster correlations owing to the entropy-enthalpy competition. This structural complexity is then inherited and amplified during the glass transition via cluster transformations, serving as dual kinetic and energetic barriers to crystallization that lead to the anomalously higher GFA. Our work establishes melt structural complexity as a new framework for understanding the glass transition at the atomic cluster level, with important implications for designing superior glasses from high-entropy intermetallic alloys.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78359"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca²⁺-CaMKK2-AMPK Signaling to Counter MASLD. 肝细胞CBX2通过提高Ca2+-CaMKK2-AMPK信号来对抗MASLD，从而保护肝脂质稳态。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78372

Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong-Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang

{"title":"Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+-CaMKK2-AMPK Signaling to Counter MASLD.","authors":"Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong-Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang","doi":"10.1002/advs.78372","DOIUrl":"10.1002/advs.78372","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one-third of adults and lacks effective pharmacological therapies. Here, we identify Chromobox 2 (CBX2), a Polycomb-associated chromatin regulator, as a previously unrecognized regulator of hepatic lipid homeostasis. CBX2 expression is markedly reduced in hepatocytes from patients with MASLD, multiple mouse models (db/db, ob/ob, HFD, and HFHC), and steatotic hepatocytes in vitro. Hepatocyte-specific CBX2 overexpression ameliorates hepatic steatosis, improves glucose metabolism, and suppresses inflammation, whereas CBX2 deficiency exacerbates these metabolic disturbances. Mechanistically, CBX2 enhances H3K4me3 enrichment at the Orai1 promoter, promoting Orai1 transcription and increasing intracellular Ca2+ levels. Elevated Ca2+ activates the CaMKK2-AMPK signaling pathway, leading to ACC phosphorylation, inhibition of de novo lipogenesis (FAS, ACC, and SCD-1), enhancement of fatty acid oxidation (PPARα and CPT-1a), and suppression of NF-κB/JNK-mediated inflammation. Genetic and pharmacological interventions further establish the necessity of this Ca2+-CaMKK2-AMPK axis for CBX2-mediated metabolic protection. Collectively, our findings reveal a CBX2-driven metabolic regulatory circuit and highlight CBX2 and its downstream signaling pathway as potential therapeutic targets for MASLD.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78372"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism-Like Behaviors via the CCL5-CCR1/5-β-catenin Signaling Axis. 小胶质细胞PBRM1缺失通过CCL5-CCR1/5-β-catenin信号轴导致过度神经发生和自闭症样行为

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78086

Yang-Yang Duan, Lin-Fei Jiao, Pei-Pei Liu, Chun-Hui Duan, Xiao Li, Zi-Han Zhang, Yue-Qi Zhang, Xin-Li Ouyang, Hong-Zhen Du, Sha Liu, Yi Tang, Zhao-Qian Teng, Chang-Mei Liu

{"title":"PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism-Like Behaviors via the CCL5-CCR1/5-β-catenin Signaling Axis.","authors":"Yang-Yang Duan, Lin-Fei Jiao, Pei-Pei Liu, Chun-Hui Duan, Xiao Li, Zi-Han Zhang, Yue-Qi Zhang, Xin-Li Ouyang, Hong-Zhen Du, Sha Liu, Yi Tang, Zhao-Qian Teng, Chang-Mei Liu","doi":"10.1002/advs.78086","DOIUrl":"10.1002/advs.78086","url":null,"abstract":"The prevalence of autism spectrum disorder (ASD), a heterogeneous neurodevelopmental disorder with limited effective therapeutic drugs, has been rising worldwide. Missense mutations in Polybromo 1 (Pbrm1), a core component of the SWI/SNF (switch/sucrose non-fermentable) chromatin remodeling complex, have been identified as a risk factor for ASD; however, whether PBRM1 loss of function contributes to the pathogenesis remains elusive. Here we provide direct evidence that microglial PBRM1 deficiency leads to altered microglial clusters, excessive neurogenesis, and ASD-like behaviors in mice. Integrated molecular analyses reveal that PBRM1 directly binds to the Ccl5 promoter and represses the expression of CCL5. Elevated CCL5 promotes the proliferation and neuronal differentiation of neural stem/progenitor cells (NSPCs) via the CCR1/5-β-catenin signaling pathway. Importantly, pharmacological blockade of CCR1/5 ameliorates behavioral deficits in Pbrm1 cKO mice. Together, these findings identify a previously unrecognized microglia-NSPC communication mechanism linking PBRM1 dysfunction to aberrant neurodevelopment and suggest the CCL5-CCR1/5 axis as a potential therapeutic target for ASD.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78086"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal Computational Meta-Imager for Broadband Dual-Layer Optical Convolution. 宽带双层光卷积的时空计算元成像仪。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78340

Mengguang Wang, Chenglong Zheng, Huaping Zang, Changwei Zhang, Huai Xia, Chang Wang, Zhenrong Zheng

{"title":"Spatiotemporal Computational Meta-Imager for Broadband Dual-Layer Optical Convolution.","authors":"Mengguang Wang, Chenglong Zheng, Huaping Zang, Changwei Zhang, Huai Xia, Chang Wang, Zhenrong Zheng","doi":"10.1002/advs.78340","DOIUrl":"10.1002/advs.78340","url":null,"abstract":"Optical neural networks face a tradeoff between device footprint and computational expressivity: deep systems are bulky, whereas single-layer hardware lacks intrinsic depth and native negative-weight support. We experimentally demonstrate a single-layer metalens imager with \"spatiotemporal intrinsic depth\" for equivalent broadband dual-layer convolution. A polarization-multiplexed metasurface provides fixed Bessel-vortex channels (l = 0 to 3) as the immutable first convolution layer, where the (l = 0) channel implements a hardware-native residual connection. A metasurface-generated 3 × 3 optical vortex matrix forms the second functional layer; time-sequential liquid-crystal amplitude modulation delivers tunable positive/negative weights. This temporal encoding solves the optical sign problem and converts fabrication imperfections into compensable biases via in-situ training. Experiments verify rotational robustness for fashion-item classification, raise full-color CIFAR-10 accuracy from 57.5 % to 86.6 %, and reach 99.3 % on the SIPaKMeD medical dataset, offloading 99.7 % of convolutional multiply-accumulate operations to optics. By removing volumetric diffractive layers, this work enables low-latency hybrid optoelectronic edge intelligent vision.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78340"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering Electrochemical Generation, Transport, and Reactivity of Hydrogen Species in the Electrochemical Palladium Membrane Reactor. 破译电化学钯膜反应器中氢的生成、传输和反应性。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78365

Samuel J Shin, Su Bin Roh, Hyun-Tak Kim, Kwan-Young Lee, Soo Min Kim, Ji Hoon Park, Minju Park

{"title":"Deciphering Electrochemical Generation, Transport, and Reactivity of Hydrogen Species in the Electrochemical Palladium Membrane Reactor.","authors":"Samuel J Shin, Su Bin Roh, Hyun-Tak Kim, Kwan-Young Lee, Soo Min Kim, Ji Hoon Park, Minju Park","doi":"10.1002/advs.78365","DOIUrl":"10.1002/advs.78365","url":null,"abstract":"Electrochemical palladium membrane reactor (ePMR) enables hydrogenation chemistry by mechanically separating, but (electro)chemically coupling reduction and chemical hydrogenation by transporting hydrogen species through a dense Pd membrane, yet the identity and transport mechanism of the reactive hydrogen species remain underdefined. Here, we disentangled the roles of hydrogen species, including hydrogen atoms and molecules for both electrochemical and chemical compartments using 1hexyne electrochemical hydrogenation reaction as a model reaction. Tafel analysis with H/D electrolytes, isotopic effects, and quantification of products show that the apparent kinetics were strongly affected by the electron transfer kinetics and hydrogen permeation through the Pd membrane. Furthermore, mathematical description of hydrogen atom transport through the Pd membrane provided qualitative model framework. Electrochemically deposited Pd, Rh, and PdRh layers with controlled thickness and morphology tuned the reaction pathway of hydrogen atom vs. H2-mediation at the chemical compartment, enabling systematic variation of 1-hexyne conversion and n-hexane selectivity. A dominant role of in situ generation and re-dissociation of H*/H2 was observed in the hydrogenation process, supported by control experiments including gas-purging experiments. Collectively, these insights establish design principles of surface engineering for ePMR, strategically coupling atomic and molecular hydrogen pathways for efficient and selective organic hydrogenation.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78365"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyrolyzed Photoresist as a Continuous-Tone Mask for Grayscale Lithography. 热解光刻胶作为灰度光刻的连续色调掩模。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78394

Tielyr D Creason, Gavin C Gee, Zachary T Piontkowski, Toai Ton-That, Robert Reyna, Edward R Arata, Mason Risley, Jacob D Boissiere, Bryan Kaehr, D Bruce Burckel

{"title":"Pyrolyzed Photoresist as a Continuous-Tone Mask for Grayscale Lithography.","authors":"Tielyr D Creason, Gavin C Gee, Zachary T Piontkowski, Toai Ton-That, Robert Reyna, Edward R Arata, Mason Risley, Jacob D Boissiere, Bryan Kaehr, D Bruce Burckel","doi":"10.1002/advs.78394","DOIUrl":"10.1002/advs.78394","url":null,"abstract":"Grayscale lithography enables single-step fabrication of continuous 3D surface relief for complex optics, MEMS, and scalable replication templates. However, its broad adoption is hindered by the cost, complexity, and resolution constraints associated with fabricating high-quality grayscale masks. Here, we address this challenge by developing a method to produce continuous-tone photolithography masks/reticles through the pyrolysis of 2.5D photoresist structures fabricated using standard multiphoton lithography systems. During pyrolysis, the pattern densifies from micrometers in thickness in the resist state to nanometers in thickness in the carbon state. While the pyrolyzed patterns undergo significant vertical shrinkage, adhesion to the substrate is maintained, preserving overall lateral pattern fidelity despite a systematic in-plane expansion. The amorphous carbon is chemically inert and mechanically robust, enabling repeated exposure and mask cleaning steps, converting the single-use polymer pattern written via direct-write technology into an optical mask capable of repeated exposures.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78394"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Habitat-Specific Design Strategies for Untethered Soft Robots. 无系绳软机器人栖息地特定设计策略。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.78287

Siyang Li, Zhikun Miao, Tuck-Whye Wong, Tiefeng Li

{"title":"Habitat-Specific Design Strategies for Untethered Soft Robots.","authors":"Siyang Li, Zhikun Miao, Tuck-Whye Wong, Tiefeng Li","doi":"10.1002/advs.78287","DOIUrl":"10.1002/advs.78287","url":null,"abstract":"Untethered soft robots are governed by habitat-specific constraints because operation without physical tethers requires their compliant structures, actuation mechanisms, and energy-delivery pathways to remain compatible with the environment. Adopting a habitat-centric framework, this review compares untethered soft robots across terrestrial, aquatic, aerial, and in vivo environments. On terrestrial substrates, design strategies are shaped by locomotion-specific demands, including contact modulation in crawling, energy storage and release in jumping, switchable adhesion in climbing, and granular fluidization in burrowing. In aquatic habitats, the dominant constraint shifts with depth, from capillary support at the air-water interface, to hydrodynamic drag in shallow water, and to hydrostatic pressure in the deep sea. In aerial environments, strict mass and power limits favor actively flapping insect-scale robots, buoyancy-assisted vehicles, and passively dispersed aeroelastic structures. In vivo, miniaturization and biocompatibility confine the viable design space to magnetic, acoustic, and biohybrid actuation. A multi-environment comparison shows that no single actuation modality is universally optimal. Each habitat filters actuation strategies by the compatibility between energy transmission and the local medium. Material longevity, onboard energy autonomy, multi-environment transition, extraterrestrial operation, and perception and feedback control are identified as cross-cutting challenges whose resolution is required to translate laboratory demonstrations into real-world deployment.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e78287"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle. OGDH复合物的一种微肽成分调节TCA循环中ATP的产生。

IF 14.1 1区材料科学

Advanced Science Pub Date : 2026-10-18 DOI: 10.1002/advs.77242

Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu

{"title":"A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle.","authors":"Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu","doi":"10.1002/advs.77242","DOIUrl":"10.1002/advs.77242","url":null,"abstract":"Since its elucidation, the tricarboxylic acid (TCA) cycle has been regarded as a fully defined enzymatic pathway. Here, we report the discovery of a previously unrecognized micropeptide component of this central metabolic system. Through analyzing ribosome profiling data from the mouse sORFs.org database, we discovered APPM (ATP production-promoting micropeptide), a 29-amino acid peptide encoded by a non-canonical small open reading frame within the mouse Ctsb gene. APPM localizes to the mitochondrial matrix and inner membrane, where it directly binds to the E1 subunit (OGDH) of the α-ketoglutarate dehydrogenase complex (OGDHc). This interaction modulates OGDHc enzymatic activity, thereby regulating NADH and ATP production. We identified tyrosine-13 as the critical residue mediating the APPM-OGDH interaction and functional activation. Exogenous APPM administration increased ATP levels in vivo and, in a mouse model of heart failure, restored cardiac function, outperforming the reference drug trimetazidine. Collectively, our findings identify APPM as the first micropeptide regulator of the OGDH complex, expanding the known repertoire of the TCA cycle and presenting a potential therapeutic strategy for diseases characterized by bioenergetic insufficiency.","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e77242"},"PeriodicalIF":14.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0