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Stimuli-Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202410030

Xi-jian Dai, Wen-Jia Li, Dong-Dong Xie, Bi-xia Liu, Lianggeng Gong, Hai-Hao Han

{"title":"Stimuli-Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases","authors":"Xi-jian Dai, Wen-Jia Li, Dong-Dong Xie, Bi-xia Liu, Lianggeng Gong, Hai-Hao Han","doi":"10.1002/smll.202410030","DOIUrl":"https://doi.org/10.1002/smll.202410030","url":null,"abstract":"Nanomaterials with unparalleled physical and chemical attributes have become a cornerstone in the field of nanomedicine delivery. These materials can be engineered into various functionalized nanocarriers, which have become the focus of research. Stimulus-responsive nanodrug delivery systems (SRDDS) stand out as a sophisticated class of nanocarriers that can release drugs in response to environmental cues. Due to the complex pathogenesis and the multifaceted pathological environment of the nervous system, developing accurate and effective drug therapy with low side-effects is a formidable task. In recent years, SRDDS have been widely used in the treatment of neurological diseases. By customizing SRDDS to align with the specific microenvironment of the nervous system tissues or external stimulation, the efficacy of drug delivery can be enhanced. This review provides an in-depth look at the characteristics of the microenvironment of neurological diseases and highlights case studies of SRDDS tailored to treat these disorders based on the unique stimulation criteria of nervous system tissues or external triggers. Additionally, this review provides a comprehensive overview of the progress and future prospects of SRDDS technology in the treatment of neurological diseases, providing valuable guidance for its transition from fundamental research to clinical application.","PeriodicalId":228,"journal":{"name":"Small","volume":"120 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Backbone Engineering of Bithiophene Imide Dimer-Based Polymeric Mixed Ionic-Electronic Conductors for High-Performance n-Type Organic Electrochemical Transistors

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202408716

Xiage Zhang, Rongjin Zhu, Wanli Yang, Keli Wang, Riqing Ding, Sang Young Jeong, Han Young Woo, Kui Feng, Xugang Guo

{"title":"Backbone Engineering of Bithiophene Imide Dimer-Based Polymeric Mixed Ionic-Electronic Conductors for High-Performance n-Type Organic Electrochemical Transistors","authors":"Xiage Zhang, Rongjin Zhu, Wanli Yang, Keli Wang, Riqing Ding, Sang Young Jeong, Han Young Woo, Kui Feng, Xugang Guo","doi":"10.1002/smll.202408716","DOIUrl":"https://doi.org/10.1002/smll.202408716","url":null,"abstract":"Polymeric mixed ionic-electronic conductors (PMIECs) are gaining significant attention due to their potential applications in organic electrochemical transistors (OECTs). However, the performance of n-type OECTs still lags behind that of their p-type counterparts. Here, the structure-performance correlation of fused bithiophene imide dimer (BTI2)-based PMIECs is systematically investigated with the backbone evaluation from acceptor-strong donor (A-SD) to acceptor-donor (A-D), to acceptor-weak donor (A-WD), to acceptor-weak acceptor (A-WA), and finally to A-A structures. Compared to other PMIECs, the A-A backbone-based PMIEC PBTI2g-BTI features the most suppressed lowest unoccupied molecular orbital energy level, a highly planar backbone, and superior n-type electrochemical dopability. Consequently, polymer PBTI2g-BTI delivers an exceptional unipolar n-type OECT performance with a high electron mobility of 0.25 cm2 V⁻¹ s⁻¹ and a remarkable µC* value of 63.79 F cm⁻¹ V⁻¹ s⁻¹, both of which are significantly higher than those of other types of PMIECs. This study demonstrates that the A-A backbone strategy is an effective approach to developing high-performance n-type PMIECs for applications in OECTs.","PeriodicalId":228,"journal":{"name":"Small","volume":"24 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Positive Charge Performance in Triboelectric Series: Molecular Engineering of Conjugated Mesoporous Fibers for Machine Learning-Based Wearable Sensors (Small 3/2025)

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202570023

Jingzhe Sun, Songah Jeong, Zihao Zheng, Bingqi Ren, Seunghye Han, Yongwei Li, Jihyun Bae, Yong Xiang, Hyungwoo Kim, Jong-jin Park

引用次数: 0

Selective Void Deposition by Continuous, Ultrathin Ag Film Enabled Stable, High-Performance AgNWs-Based Transparent Heaters (Small 3/2025)

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202570020

Sanh Vo Thi, Thanh Tai Nguyen, Malkeshkumar Patel, Priyanka Bhatnagar, Chanhyuk Choi, Junghyun Lee, Vinh-Ai Dao, Joondong Kim

引用次数: 0

Self-Oxidated Hybrid Conductive Network Enables Efficient Electrochemical Lithium Extraction Under High-Altitude Environment (Small 3/2025)

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202570021

Zhixin Wan, Ziqi Liu, Yiyang Xiao, Qinqin Ruan, Qian Wang, Haitao Zhang, Meng Yao, Yun Zhang

引用次数: 0

Isomerization of Covalent Organic Frameworks for Efficiently Activating Molecular Oxygen and Promoting Hydrogen Peroxide Photosynthesis (Small 3/2025)

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202570017

Wenjiao Wang, Rui Zhang, Hongqi Chu, Zhen Zhan, Qi Huang, Zhenzi Li, Xuepeng Wang, Fuquan Bai, Wei Zhou

引用次数: 0

Advances on Defect Engineering of Niobium Pentoxide for Electrochemical Energy Storage

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202410211

Liaona She, Dongye Liu, Yin Zhao, Linyao Dong, Zhijun Wu, Xu Xue, Ye Tian, Wubin Du, Chao Zheng, Shengnan He, Mingchang Zhang, Yanxia Liu, Jiantuo Gan, Chenchen Li, Yong Gao, Fulai Qi, Xiangrong Ren, Yinzhu Jiang, Yaxiong Yang, Mingxia Gao, Hongge Pan

{"title":"Advances on Defect Engineering of Niobium Pentoxide for Electrochemical Energy Storage","authors":"Liaona She, Dongye Liu, Yin Zhao, Linyao Dong, Zhijun Wu, Xu Xue, Ye Tian, Wubin Du, Chao Zheng, Shengnan He, Mingchang Zhang, Yanxia Liu, Jiantuo Gan, Chenchen Li, Yong Gao, Fulai Qi, Xiangrong Ren, Yinzhu Jiang, Yaxiong Yang, Mingxia Gao, Hongge Pan","doi":"10.1002/smll.202410211","DOIUrl":"https://doi.org/10.1002/smll.202410211","url":null,"abstract":"The reasonable design of advanced anode materials for electrochemical energy storage (EES) devices is crucial in expediting the progress of renewable energy technologies. Nb2O5 has attracted increasing research attention as an anode candidate. Defect engineering is regarded as a feasible approach to modulate the local atomic configurations within Nb2O5. Therefore, introducing defects into Nb2O5 is considered to be a promising way to enhance electrochemical performance. However, there is no systematic review on the defect engineering of Nb2O5 for the energy storage process. This review systematically analyzes first the crystal structures and energy storage mechanisms of Nb2O5. Subsequently, a systematical summary of the latest advances in defect engineering of Nb2O5 for EES devices is presented, mainly focusing on vacancy modulation, ion doping, planar defects, introducing porosity, and amorphization. Of particular note is the effects of defect engineering on Nb2O5: improving electronic conductivity, accelerating ion diffusion, maintaining structural stability, increasing active storage sites. The review further summarizes diverse methodologies for inducing defects and the commonly used techniques for the defect characterization within Nb2O5. In conclusion, the article proposes current challenges and outlines future development prospects for defect engineering in Nb2O5 to achieve high-performance EES devices with both high energy and power densities.","PeriodicalId":228,"journal":{"name":"Small","volume":"33 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chiral and Quantum Plasmonic Sensors: New Frontiers in Selective and Ultra-Sensitive Sensing

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202409197

Dev Kumar Thapa, Soumava Biswas

{"title":"Chiral and Quantum Plasmonic Sensors: New Frontiers in Selective and Ultra-Sensitive Sensing","authors":"Dev Kumar Thapa, Soumava Biswas","doi":"10.1002/smll.202409197","DOIUrl":"https://doi.org/10.1002/smll.202409197","url":null,"abstract":"Surface Plasmon Polaritons (SPPs) and Localized Surface Plasmon Resonances (LSPRs) are fundamental phenomena in plasmonics that enable the confinement of electromagnetic waves beyond the diffraction limit. This confinement results in a significant enhancement of the electric field, making this phenomenon particularly beneficial for sensitive detection applications. However, conventional plasmonic sensors face several challenges, notably their difficulty in distinguishing chiral molecules, which are vital in drug development. Furthermore, these sensors exhibit sensitivity issues and energy losses, leading to broader resonance peaks and diminished signal-to-noise ratios. Recent research has concentrated on integrating chirality and quantum effects in plasmonics to overcome these limitations. Particularly, the development of plasmonic sensors with exceptional sensitivity and precision at scales smaller than the diffraction limit. This review assesses the latest advancements in chiral and quantum plasmonic sensing technologies. The first section details the theory and operational principles of conventional sensors based on SPPs and LSPRs. The second section discusses recent developments in chiral plasmonic sensors, while the third section focuses on plasmonic quantum sensing, highlighting contemporary findings. Specifically, this section emphasizes quantum-enhanced sensing techniques that mitigate shot noise, a significant barrier to single-molecule detection. The concluding section summarizes the review and identifies potential future research directions.","PeriodicalId":228,"journal":{"name":"Small","volume":"12 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging Long-Life Alkaline Redox Flow Batteries Using Durable and High-Hydroxide Exchange N-Bridged Triazine Framework Membranes

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202406395

Jeet Sharma, Richa Gupta, Kothandaraman Ramanujam, Vaibhav Kulshrestha

{"title":"Leveraging Long-Life Alkaline Redox Flow Batteries Using Durable and High-Hydroxide Exchange N-Bridged Triazine Framework Membranes","authors":"Jeet Sharma, Richa Gupta, Kothandaraman Ramanujam, Vaibhav Kulshrestha","doi":"10.1002/smll.202406395","DOIUrl":"https://doi.org/10.1002/smll.202406395","url":null,"abstract":"Fluorine-free organic framework polyelectrolyte membranes showing near frictionless ionic conductivities are gaining cognitive insights. However, the co-precipitation of COFs in the membranes often brings trade-offs to commission long-life electrochemical energy storage solutions. Herein, a durable and ionically miscible dual-ion exchange membrane based on triazine organic framework (TOF) is designed for alkaline redox flow batteries (RFB). Bearing dual ion-exchange architectures, the all-hydrocarbon TOF-based PEMs (sTOF's) surpass fluorinated Nafion in terms of energy efficiency (>80%), energy density, and peak power densities. The fabricated sTOF's evidenced the highest net ion-exchange of >2.1 meq g−1 which encourages electrolyte utilization with ≈100% and offers excellent capacities. Moreover, >97% efficiencies are preserved, and rate capability studies illustrate that, with sTOF-5, the RFB can operate at reduced overpotentials (η ≤200 mV) and can uplift batteries life. The sTOF's supports successful demonstrations of batteries at higher redoxolyte concentrations thereby multiplying the energy densities. The afterlife performance of sTOF-5 revealed efficiencies equivalent to fresh Nafion-117 and surpassed bearing >50% capacity after ≈3000 continuous cycles. With sTOF-5, the cell delivered a peak power (Pmax) of 2.3 W which is ≈60% higher than that of Nafion-117 (Pmax = 1.45 W).","PeriodicalId":228,"journal":{"name":"Small","volume":"81 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Situ Anchoring Functional Molecules to Polymer Chains Through Supramolecular Interactions for a Robust and Self-Healing Multifunctional Waterborne Polyurethane

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202410933

Chen Zhou, Nana Zhao, Weiqi Liu, Fukang Hao, Mengjie Han, Jinfeng Yuan, Zhicheng Pan, Mingwang Pan

{"title":"In Situ Anchoring Functional Molecules to Polymer Chains Through Supramolecular Interactions for a Robust and Self-Healing Multifunctional Waterborne Polyurethane","authors":"Chen Zhou, Nana Zhao, Weiqi Liu, Fukang Hao, Mengjie Han, Jinfeng Yuan, Zhicheng Pan, Mingwang Pan","doi":"10.1002/smll.202410933","DOIUrl":"https://doi.org/10.1002/smll.202410933","url":null,"abstract":"Nowadays, much attention is paid to the development of high-performance and multifunctional materials, but it is still a great challenge to obtain polymer materials with high mechanical properties, high self-healing properties, and multifunctionality in one. Herein, an innovative strategy is proposed to obtain a satisfactory waterborne polyurethane (PMWPU-Bx) by in situ anchoring 3-aminophenylboronic acid (3-APBA) in a pyrene-capped waterborne polyurethane (PMWPU) via supramolecular interactions. The multiple functional sites inherent in 3-APBA can produce supramolecular interactions with groups on PMWPU, promoting the aggregation of hard domains in the polymer network, which confers the PMWPU-Bx strength (7.9 MPa) and high modulus (243.2 MPa). Meanwhile, the dynamic natures of boronic ester bonds formed by the condensation of 3-APBA endow PMWPU-Bx with a high self-healing efficiency. Additionally, PMWPU-Bx exhibits fluorescence tunability due to the controlled π–π stacking. In this research, the strategy of anchoring functional molecules onto polymers through supramolecular interactions synchronously achieves the high performance and the multi-functionality of waterborne polyurethanes, but also broadens their potential applications in the fields of optical anticounterfeiting and encrypted information transmission.","PeriodicalId":228,"journal":{"name":"Small","volume":"32 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0