Small最新文献 - Book学术

Transfer‐Printed Wrinkled PVDF‐Based Tactile Sensor‐Nanogenerator Bundle for Hybrid Piezoelectric‐Triboelectric Potential Generation 转移-印刷褶皱PVDF -基于触觉传感器-纳米发电机束混合压电-摩擦电势产生

IF 13.3 2区材料科学

Small Pub Date : 2025-05-08 DOI: 10.1002/smll.202502767

Kamal Kumar Meena, Injamamul Arief, Anik Kumar Ghosh, André Knapp, Mirko Nitschke, Andreas Fery, Amit Das

{"title":"Transfer‐Printed Wrinkled PVDF‐Based Tactile Sensor‐Nanogenerator Bundle for Hybrid Piezoelectric‐Triboelectric Potential Generation","authors":"Kamal Kumar Meena, Injamamul Arief, Anik Kumar Ghosh, André Knapp, Mirko Nitschke, Andreas Fery, Amit Das","doi":"10.1002/smll.202502767","DOIUrl":"https://doi.org/10.1002/smll.202502767","url":null,"abstract":"Triboelectric sensors are known for their ultrahigh sensitivity and wide‐range detectability of tactile force/pressure, all while being self‐powered. However, the energy harvesting efficiency of triboelectric nanogenerators (TENGs) is often limited by relatively low output power density, when compared to other state‐of‐the‐art microgenerators. To address this challenge and achieve high force/pressure detection while maintaining excellent tactile resolution, a hybrid nanogenerator is proposed that comprises of both triboelectric and piezoelectric components within a ferroelectric polyvinylidene fluoride (PVDF) polymer matrix. To enhance tactile sensitivity, a coupled transfer printed‐spin coating technique is introduced to imprint wrinkled silicone structuring with tunable periodicity and amplitude directly onto PVDF. The hybrid output voltage of the wrinkled PVDF‐based TENG utilizing the ferroelectric β phase of PVDF (FE‐TENG_5) shows an impressive ≈200% increase compared to pristine FE‐TENG. The highest power density (0.9 mW cm−2) corresponds to FE‐TENG with the periodicity of 5 µm. Remarkably, the imprinted FE‐TENGs can detect even the slightest tactile force (<2 N), while the hybrid mechanism ensures a broad force sensing range, extending up to 100 N before saturation. This exceptional performance establishes the imprinted PVDF‐based FE‐TENG as a versatile tactile sensing platform for a range of cutting‐edge applications, particularly in electronic skin and next‐generation microelectronics.","PeriodicalId":228,"journal":{"name":"Small","volume":"119 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boosting Reaction Kinetics and Stability of Electrocatalytic Oxygen Evolution with Ir/CoV‐LDH/Graphene Heterogeneous Electrocatalyst Ir/CoV - LDH/石墨烯非均相电催化剂促进电催化析氧反应动力学和稳定性

IF 13.3 2区材料科学

Small Pub Date : 2025-05-08 DOI: 10.1002/smll.202410640

Xianjun Zhu, Le Fang, Zichao Zhou, Liya Qin, Longlu Wang, Xiang Chen

{"title":"Boosting Reaction Kinetics and Stability of Electrocatalytic Oxygen Evolution with Ir/CoV‐LDH/Graphene Heterogeneous Electrocatalyst","authors":"Xianjun Zhu, Le Fang, Zichao Zhou, Liya Qin, Longlu Wang, Xiang Chen","doi":"10.1002/smll.202410640","DOIUrl":"https://doi.org/10.1002/smll.202410640","url":null,"abstract":"To address the challenge of low catalytic performance in the electrocatalytic oxygen evolution reaction (OER) caused by slow reaction kinetics, a novel approach is developed utilizing the crystalline properties of iridium (Ir) and hydrogen‐related layered double hydroxide (LDH) to enhance corrosion resistance. These materials are integrated into a CoV‐LDH structure to design an Ir/CoV‐LDH/G heterogeneous electrocatalyst. This innovative heterogeneous structure not only enhances the reaction kinetics but also optimizes the electronic structure of the catalyst through interactions at the heterogeneous interface, leading to excellent electrocatalytic OER performance. Notably, the Ir/CoV‐LDH/G catalyst requires overpotentials of merely 203 and 289 mV to achieve current densities of 10 and 100 mA cm−2, respectively. Furthermore, when utilized in an Ir/CoV‐LDH/G||Pt/C electrolytic cell for overall water splitting, it delivers a current density of 10 mA·cm−2 at a cell voltage of only 1.46 V, surpassing the performance of most commercial IrO₂||Pt/C and previously reported Ir‐based and LDH electrocatalysts. The catalyst also exhibits remarkable stability, maintaining a current density of 100 mA·cm−2 for 100 h without significant degradation.","PeriodicalId":228,"journal":{"name":"Small","volume":"3 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Potassium‐Doped Perovskite‐Based Nanocomposite as an Efficient Bifunctional Oxygen Electrocatalyst for Rechargeable Zn‐Air Batteries 钾掺杂钙钛矿基纳米复合材料作为可充电锌空气电池的高效双功能氧电催化剂

IF 13.3 2区材料科学

Small Pub Date : 2025-05-08 DOI: 10.1002/smll.202502595

Zihao Xie, Hao Qiu, Jiayi Tang, Zhixian Liang, Deqing He, Beibei Xiao, Chao Su, Zongping Shao

{"title":"A Potassium‐Doped Perovskite‐Based Nanocomposite as an Efficient Bifunctional Oxygen Electrocatalyst for Rechargeable Zn‐Air Batteries","authors":"Zihao Xie, Hao Qiu, Jiayi Tang, Zhixian Liang, Deqing He, Beibei Xiao, Chao Su, Zongping Shao","doi":"10.1002/smll.202502595","DOIUrl":"https://doi.org/10.1002/smll.202502595","url":null,"abstract":"Bifunctional oxygen electrocatalysts play a crucial role in the performance of rechargeable zinc‐air batteries (ZABs), directly impacting key parameters such as capacity, round‐trip efficiency, and durability. The ideal electrocatalysts for ZAB air electrodes must exhibit high catalytic activity for both oxygen reduction and oxygen evolution reactions in alkaline medium. This study presents a potassium‐ion doping strategy to engineer the electron and defect structures of the perovskite oxide main phase, promoting phase separation to form a nanocomposite consisting of a perovskite phase and a secondary phase with an intergrowth structure. The resulting nanocomposite catalyst exhibits increased concentrations of Co3+ and oxygen vacancies, enhanced hydrophilicity, and improved adsorption of oxygen intermediates. As a result, the catalyst with the optimized composition demonstrates exceptional bifunctional activity and superior durability, leading to extended cycling stability and improved energy conversion efficiency in ZABs. Notably, it achieves a 42% increase in power density compared to the potassium‐free pristine catalyst, a reduced voltage gap (ΔE = 0.83 V), and an extended cycle life of over 250 h. This work introduces a novel design paradigm for advanced metal‐air battery catalysts through potassium‐promoted defect‐engineered heterostructure manipulation of perovskite oxides.","PeriodicalId":228,"journal":{"name":"Small","volume":"228 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gray‐Level Guided Image‐Activated Droplet Sorter for Label‐Free, High‐Accuracy Screening of Single‐Cell on Demand 灰度引导图像激活液滴分选仪，用于无标签，高精度的单细胞筛选

IF 13.3 2区材料科学

Small Pub Date : 2025-05-08 DOI: 10.1002/smll.202500520

Zhen Liu, Yidi Zhang, Jianing Li, Shuxun Chen, Han Zhao, Xin Zhao, Dong Sun

{"title":"Gray‐Level Guided Image‐Activated Droplet Sorter for Label‐Free, High‐Accuracy Screening of Single‐Cell on Demand","authors":"Zhen Liu, Yidi Zhang, Jianing Li, Shuxun Chen, Han Zhao, Xin Zhao, Dong Sun","doi":"10.1002/smll.202500520","DOIUrl":"https://doi.org/10.1002/smll.202500520","url":null,"abstract":"Single‐cell encapsulation in droplet microfluidics has become a powerful tool in precision medicine, single‐cell analysis, and immunotherapy. However, droplet generation with a single‐cell encapsulation is a random process, which also results in a large number of empty and multi‐cell droplets. Current microfluidics sorting technologies suffer from drawbacks such as fluorescent labeling, inability to remove multi‐cell droplets, or low throughput. This paper presents a gray‐level guided image‐activated droplet sorter (GL‐IADS), which enables label‐free, high‐accuracy screening of single‐cell droplets by rejecting empty and multi‐cell droplets. The gray‐level based recognition method can accurately classify droplet images (empty, single‐cell, and multi‐cell droplets), especially in differentiating empty and cell‐laden droplets (accuracy of 100%). Crucially, this method reduces the image processing time to ≈300 µs, which makes the GL‐IADS possible to reach an ultra‐high sorting throughput up to hundreds or even KHz. The GL‐IADS integrates the novel recognition method with a detachable acoustofluidic system, achieving sorting purity of 97.9%, 97.4%, and >99% for single‐cell, multi‐cell, and cell‐laden droplets, respectively, with a throughput of 43 Hz. The GL‐IADS holds promise for numerous biological applications that are previously difficult with fluorescence‐based technologies.","PeriodicalId":228,"journal":{"name":"Small","volume":"25 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design Principles of Nanosensors for Multiplex Detection of Contaminants in Food. 食品中污染物多重检测的纳米传感器设计原理。

IF 13.3 2区材料科学

Small Pub Date : 2025-05-07 DOI: 10.1002/smll.202412271

Yang Zhang,Shipeng Gao,Haoran Li,Tianxi Yang,Kaiyi Zheng,Zhing Ming Guo,Jiyong Shi,Xiaowei Huang,Xiaobo Zou,Pierre Picchetti,Frank Biedermann

{"title":"Design Principles of Nanosensors for Multiplex Detection of Contaminants in Food.","authors":"Yang Zhang,Shipeng Gao,Haoran Li,Tianxi Yang,Kaiyi Zheng,Zhing Ming Guo,Jiyong Shi,Xiaowei Huang,Xiaobo Zou,Pierre Picchetti,Frank Biedermann","doi":"10.1002/smll.202412271","DOIUrl":"https://doi.org/10.1002/smll.202412271","url":null,"abstract":"The rapid and cost-effective detection of food contaminants such as toxins and pathogens is a major challenge and a key concern for food safety. To this end, innovative, fast, cost-effective, and easy-to-use sensors must be developed at the point where food is produced, distributed, and consumed. Therefore, timely detection and response to food contaminants can improve human health and reduce economic burden. However, affordable sensor technologies with specificity, sensitivity, and speed are required, which can be used by non-specialized personnel and enable high throughput analysis. In this respect, advances in the development of nanoparticle-based sensors, i.e., nanosensors, have shown the potential to provide the much-anticipated versatile sensors. In addition, multiplex detection, i.e., the ability to detect multiple targets simultaneously, is another strategy facilitated by nanoparticle-based sensors and will enable further improvements in sensor performance that are important for developing effective monitoring. This review summarizes the nanosensors for multiplex sensing of food samples with respect to hazardous contaminates reported over the past few years. In addition, special attention is paid to providing the reader with promising design principles and the current performance of the sensitivity and selectivity of such sensors for practical requirements, thereby inspiring new ideas for developing further advanced systems.","PeriodicalId":228,"journal":{"name":"Small","volume":"7 1","pages":"e2412271"},"PeriodicalIF":13.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White Light Emission from Luminescent Lanthanide Molecular Complex/Terbium Doped Graphene Quantum Dots/PMMA Composites. 发光镧系分子复合物/掺铽石墨烯量子点/PMMA复合材料的白光发射

IF 13.3 2区材料科学

Small Pub Date : 2025-05-07 DOI: 10.1002/smll.202503419

Uttam Sarkar,Sagarika Bhattacharya

{"title":"White Light Emission from Luminescent Lanthanide Molecular Complex/Terbium Doped Graphene Quantum Dots/PMMA Composites.","authors":"Uttam Sarkar,Sagarika Bhattacharya","doi":"10.1002/smll.202503419","DOIUrl":"https://doi.org/10.1002/smll.202503419","url":null,"abstract":"Construction of multicolor emissive PMMA composite films are reported using luminescent lanthanide Schiff-Base complexes and Terbium doped Graphene Quantum dots (GQD@Tb) for white light generation. Terbium-doped green emissive Graphene Quantum Dots are synthesized hydrothermally using ortho-phenyldiammine (OPDA), Triethylamine and Tb(NO3)3.6H2O and is thoroughly characterized by microscopic and spectroscopic techniques. Isostructural lanthanides (III) complexes [DyIII 2(L)2(NO3)2(dmf)2] (1), and [SmIII 2(L)2(NO3)2(dmf)2] (2) are isolated from an organic Schiff base ligand, H2L, ligand is prepared by 1:1 condensation of salicylaldehyde and 2-(2-Aminoethoxy)ethanol, and are characterized. The photoluminescent data analysis reveals green emission of GQD@Tb, pure blue emissive DyIIIL and red emission of SmIIIL. Additionally, intensified ligand emission attests for the blue emitter-DyIIIL complex while the \"antenna effect\" is witnessed for red fluorophore SmIIIL. Co-doping of metal complexes and GQD@Tb into the Poly(methyl methylacrylate) [PMMA] polymer improves luminescence intensity due to inhibition of aggregation-induced quenching. By conscientious combination of red-SmIIIL with green-GQD@Tb in a specified concentration, distinct white light is accomplished for the first time with Commission Internationale de I'Éclairage (CIE) values of 0.29, 0.32, very close to the ideal white emitter. The newly developed nano and molecular complex composite of GQD@Tb and SmIIIL-PMMA films are transparent and highly desired materials in optoelectronics, microscopy, and sensing.","PeriodicalId":228,"journal":{"name":"Small","volume":"6 1","pages":"e2503419"},"PeriodicalIF":13.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Full-Graphdiyne-Based Fast-Charging Aqueous Zinc Ion Battery Toward Synergistically Boosted Capacity and Long Lifespan. 基于全石墨烯的快速充电水性锌离子电池协同提高容量和延长寿命。

IF 13.3 2区材料科学

Small Pub Date : 2025-05-07 DOI: 10.1002/smll.202502191

Zecheng Xiong,Hao Sun,Wei Su,Weiyue Jin,Hongye Liu,Yang Huang,Huibiao Liu

引用次数: 0

Enhancing Near-Infrared Photoluminescence of Ag8GeS6 Quantum Dots Through Compositional Fine-Tuning and ZnS Coating for In Vivo Bioimaging. 通过成分微调和ZnS涂层增强Ag8GeS6量子点近红外光致发光用于体内生物成像。

IF 13.3 2区材料科学

Small Pub Date : 2025-05-07 DOI: 10.1002/smll.202411142

Nurmanita Rismaningsih,Junya Kubo,Masayuki Soto,Kazutaka Akiyoshi,Tatsuya Kameyama,Takahisa Yamamoto,Hiroshi Yukawa,Yoshinobu Baba,Tsukasa Torimoto

{"title":"Enhancing Near-Infrared Photoluminescence of Ag8GeS6 Quantum Dots Through Compositional Fine-Tuning and ZnS Coating for In Vivo Bioimaging.","authors":"Nurmanita Rismaningsih,Junya Kubo,Masayuki Soto,Kazutaka Akiyoshi,Tatsuya Kameyama,Takahisa Yamamoto,Hiroshi Yukawa,Yoshinobu Baba,Tsukasa Torimoto","doi":"10.1002/smll.202411142","DOIUrl":"https://doi.org/10.1002/smll.202411142","url":null,"abstract":"Quantum dots (QDs) composed of a group I-IV-VI semiconductor, Ag8GeS6, have been intensively investigated for constructing efficient energy conversion systems. However, their potential for photoluminescence (PL)-based applications has remained unexplored. Herein, the first successful preparation of Ag8GeS6 QDs exhibiting near-infrared (NIR) PL is reported. These Ag8GeS6 QDs with an average diameter of 4.2-4.6 nm has an almost constant energy gap at 1.48-1.45 eV, even when the Ge/(Ag+Ge) precursor ratio is varied from 0.05 to 0.90. A significant PL peak is observed at 920 nm, the intensity being enlarged with an increase in the Ge/(Ag+Ge) ratio. The use of Ag8GeS6 QDs prepared with Ge/(Ag+Ge) = 0.82 in the precursors result in a PL quantum yield (QY) of 11%, which is further enhanced to 40% through surface coating with a ZnS shell of 1.0 nm in thickness, with the PL peak wavelength being slightly blue-shifted to 900 nm. Following surface modification with 3-mercaptopropionic acid for homogeneous dispersion in aqueous solutions, the Ag8GeS6@ZnS QDs are utilized as an NIR PL probe for in vivo bioimaging. PL signals are clearly detected from depths of at least 15 mm beneath the back skin of a mouse, demonstrating their deep-tissue imaging capability.","PeriodicalId":228,"journal":{"name":"Small","volume":"73 1","pages":"e2411142"},"PeriodicalIF":13.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using a Functional Wool Keratin Photoresist to Build Iridescent and Fluorescent 3D Micro-Pattern for Dual-Mode Optical Anti-Counterfeiting. 利用功能性羊毛角蛋白光刻胶构建虹彩和荧光三维微图案用于双模光学防伪。

IF 13.3 2区材料科学

Small Pub Date : 2025-05-07 DOI: 10.1002/smll.202502166

Shuang Xia,Qinghong Lu,Chaoyu Fan,Shuihong Zhu,Sen Wang,Hanqi Wang,Yimin Pan,Youhui Lin

{"title":"Using a Functional Wool Keratin Photoresist to Build Iridescent and Fluorescent 3D Micro-Pattern for Dual-Mode Optical Anti-Counterfeiting.","authors":"Shuang Xia,Qinghong Lu,Chaoyu Fan,Shuihong Zhu,Sen Wang,Hanqi Wang,Yimin Pan,Youhui Lin","doi":"10.1002/smll.202502166","DOIUrl":"https://doi.org/10.1002/smll.202502166","url":null,"abstract":"The construction of bio-nanostructures plays a critical role in the advancement of applications across bioelectronics, bio-optical devices, and biomedicine. Among various fabrication techniques, soft lithography emerges as an efficient and scalable method for producing high-quality intricate surface micropatterns. Herein, a mild and aqueous approach is developed to endow biocompatible wool keratin (WK) with photoresponsiveness; and utilize the gold nanoclusters (AuNCs) incorporated functional bio-photoresist to build iridescent and fluorescent micrometer-scale patterns for dual-mode optical anti-counterfeiting. Specifically, the chemical modification of WK is achieved by using glycidyl methacrylate under mild conditions. And then, the modified WK can function as a green bio-photoresist, which can be cross-linked via UV light-initiated radical polymerization. By combining soft lithography, both positive and negative 3D WK micro-patterns with stability, biocompatibility, and controlled degradability can be facilely fabricated. Notably, the obtained periodic microstructures exhibit typical iridescent behavior with an excellent diffraction efficiency. Interestingly, by using WK as both a reductant and a stabilizer, the AuNCs functional WK resist with significant fluorescence response can be in situ generated. More importantly, through the skillful combination of iridescent micro-patterns and fluorescence, the WK/AuNCs-based hybrid micro-patterns can be further used for dual-mode optical anti-counterfeiting, which can significantly enhance information storage and encryption security.","PeriodicalId":228,"journal":{"name":"Small","volume":"142 1","pages":"e2502166"},"PeriodicalIF":13.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degradable Metal-Small Molecule Drug Coordination Nanomedicines for DNA Damage-Augmented Cancer Chemodynamic Therapy. 可降解金属-小分子药物配位纳米药物用于DNA损伤增强癌症化学动力学治疗。

IF 13.3 2区材料科学

Small Pub Date : 2025-05-07 DOI: 10.1002/smll.202501721

Renting Jiang,Jinchan Rao,Hua Su,Ming Li

{"title":"Degradable Metal-Small Molecule Drug Coordination Nanomedicines for DNA Damage-Augmented Cancer Chemodynamic Therapy.","authors":"Renting Jiang,Jinchan Rao,Hua Su,Ming Li","doi":"10.1002/smll.202501721","DOIUrl":"https://doi.org/10.1002/smll.202501721","url":null,"abstract":"The intrinsic DNA damage repair response represents a major limiting factor for the therapeutic efficacy of many anticancer therapies such as chemodynamic therapy (CDT). Here, a degradable metal-small molecule drug coordination nanomedicine (siAPE1/Cu-MP@HA) is developed for DNA damage-augmented CDT treatment of lung cancers. The design is achieved by the coordination-driven self-assembly of Cu2+ and 6-mercaptopurine (6-MP) with the siAPE1 loading and hyaluronic acid (HA) modification. The siAPE1/Cu-MP@HA possesses the tumor targeting ability and is degradable in lysosomes for specific releases of Cu2+, siAPE1, and 6-MP because of the weak acidity/glutathione (GSH) dual-responsiveness. Upon the depletion of endogenous GSH, the siAPE1/Cu-MP@HA promotes the ∙OH generation from endogenous H2O2 via the Fenton-like reaction, significantly enhancing the CDT anticancer effect. It is evidenced that the siAPE1/Cu-MP@HA treatment effectively disrupts the DNA synthesis and inhibits the DNA damage repair, thereby augmenting the DNA damage. In vivo, experiments demonstrate the remarkable therapeutic efficacy against A549 lung cancer in mice with negligible systemic toxicity after intravenous administration of the siAPE1/Cu-MP@HA. This study offers an innovative approach targeting the DNA damage repair system for enhancing CDT effects in cancer treatment.","PeriodicalId":228,"journal":{"name":"Small","volume":"137 1","pages":"e2501721"},"PeriodicalIF":13.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0