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Smart Mesoporous Silica Nanoparticles in Cancer: Diagnosis, Treatment, Immunogenicity, and Clinical Translation

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202408898

Satar Yousefiasl, Mahsa Ghovvati, Abbas Alibakhshi, Mehdi Azizi, Pouria Samadi, Arun Kumar, Ali Shojaeian, Esmaeel Sharifi, Ehsan Nazarzadeh Zare, Asmita Deka Dey, Mohammad Chehelgerdi, Pooyan Makvandi

{"title":"Smart Mesoporous Silica Nanoparticles in Cancer: Diagnosis, Treatment, Immunogenicity, and Clinical Translation","authors":"Satar Yousefiasl, Mahsa Ghovvati, Abbas Alibakhshi, Mehdi Azizi, Pouria Samadi, Arun Kumar, Ali Shojaeian, Esmaeel Sharifi, Ehsan Nazarzadeh Zare, Asmita Deka Dey, Mohammad Chehelgerdi, Pooyan Makvandi","doi":"10.1002/smll.202408898","DOIUrl":"https://doi.org/10.1002/smll.202408898","url":null,"abstract":"In cancer research and personalized medicine, mesoporous silica nanoparticles (MSNs) have emerged as a significant breakthrough in both cancer treatment and diagnosis. MSNs offer targeted drug delivery, enhancing therapeutic effectiveness while minimizing adverse effects on healthy cells. Due to their unique characteristics, MSNs provide targeted drug delivery, maximizing therapeutic effectiveness with minimal adverse effects on healthy cells. The review thoroughly investigates the role of MSNs as potent drug carriers, noted for their high drug-loading capacity and controlled release, which significantly improves drug permeability and retention. Additionally, it discusses surface modification techniques that enable MSNs to target cancer cells precisely. The manuscript provides comprehensive insights into various MSN applications, including their role in cancer diagnosis, the design of advanced biosensors, and the development of both conventional and stimuli-responsive drug delivery platforms. Special focus is given to stimuli-triggered MSN systems, responsive to internal stimuli (e.g., pH, redox, enzyme) and external stimuli (e.g., temperature, magnetic field, light, ultrasound), highlighting the cutting-edge progress in MSN technology. Additionally, the review delves into the immunogenicity and biosafety aspects of MSNs, underscoring their potential for clinical translation. Besides summarizing the current state of MSN research in oncology, this review also illuminates the path for future advancements and clinical applications.","PeriodicalId":228,"journal":{"name":"Small","volume":"25 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shortwave Infrared Imaging of a Quantum Dot-Based Magnetic Guidewire Toward Non-Fluoroscopic Peripheral Vascular Interventions (Small 3/2025)

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202570022

Junsun Hwang, Beomjoo Kim, Chaewon Jin, Gyudong Lee, Hwajun Jeong, Hyunki Lee, Jonggu Noh, Sung Jun Lim, Jin-young Kim, Hongsoo Choi

引用次数: 0

A Biodegradable, Porous Flier Inspired by a Parachute-Like Tragopogon Fruit for Environmental Preservation (Small 3/2025)

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202570019

Stefano Mariani, Kliton Cikalleshi, Marilena Ronzan, Carlo Filippeschi, Giovanna Adele Naselli, Barbara Mazzolai

引用次数: 0

Side Reaction Turned Positive: Synchronous OER Manipulating the Electrocatalytic Properties of Anodic Electrodeposited Lead Dioxide

IF 13.3 2区材料科学

Small Pub Date : 2025-01-22 DOI: 10.1002/smll.202410556

Hua Guo, Xinyuan Li, Mingtao Li, Liu Yang, Wei Yan, Hao Xu

{"title":"Side Reaction Turned Positive: Synchronous OER Manipulating the Electrocatalytic Properties of Anodic Electrodeposited Lead Dioxide","authors":"Hua Guo, Xinyuan Li, Mingtao Li, Liu Yang, Wei Yan, Hao Xu","doi":"10.1002/smll.202410556","DOIUrl":"https://doi.org/10.1002/smll.202410556","url":null,"abstract":"The preparation and modification of porous electrodes are an important component of the new generation electrochemical oxidation technology. Rapid preparation of porous electrodes can be easily achieved by synchronous oxygen bubble electrodeposition. However, according to the reaction mechanism of lead dioxide anodic electrodeposition, there is bound to be a competitive reaction of adsorbed hydroxyl radicals in the oxygen bubble template method, which means that synchronous OER impacts both the surface morphology and potentially the crystalline structure of the metal oxides. Clarifying the comprehensive influence of synchronous OER on the morphology and microstructure of the coating is important. In this work, the electrodeposition process of porous lead dioxide coating is regulated by the way of linear potential increase and realized the rapid preparation of high-performance porous lead dioxide coating within 40 s. The morphology and microstructure, electrical, and electrochemical properties are characterized, combined with theoretical calculation and orthogonal analysis, to investigate the regulatory mechanism of the rapid growth of the porous lead dioxide by the electric potential. It is demonstrated that synchronous OER confers porous morphology and a large number of defects to the coating in situ, and enhancing the electrocatalytic oxidation performance of the electrode.","PeriodicalId":228,"journal":{"name":"Small","volume":"10 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Self-Powered Sensitive X-Ray Detection Crystal Bi2Mo0.36W1.64O9 with Effective Functional Motif Coupling in a Quasi-2D Perovskite Structure

IF 13.3 2区材料科学

Small Pub Date : 2025-01-21 DOI: 10.1002/smll.202408041

Lishan Liu, Hanyue Zhou, Jingquan Liu, Xiangxin Tian, Zeliang Gao

{"title":"Novel Self-Powered Sensitive X-Ray Detection Crystal Bi2Mo0.36W1.64O9 with Effective Functional Motif Coupling in a Quasi-2D Perovskite Structure","authors":"Lishan Liu, Hanyue Zhou, Jingquan Liu, Xiangxin Tian, Zeliang Gao","doi":"10.1002/smll.202408041","DOIUrl":"https://doi.org/10.1002/smll.202408041","url":null,"abstract":"The demand for medical imaging with reduced patient dosage and higher resolution is growing, driving the need for advanced X-ray detection technologies. This paper proposes a design paradigm for X-ray detection semiconductors by coupling constituent motifs through crystal structure engineering. The study introduces a strongly anisotropic Aurivillius-type quasi-2D perovskite structure, combining [Bi2O2]2+ groups with stereochemically active lone pair electrons (SCALPEs) and [W/Mo2O7]2− anionic groups, enabling enhanced X-ray Compton scattering and self-powered capabilities through local electric field ordering. This results in the first self-powered Bi-based tungstate Bi2Mo0.36W1.64O9 (BMWO) X-ray detector, achieving a record self-powered sensitivity of 381 µC Gy−1 cm−2. Additionally, the study demonstrates the imaging capability of a Bi-based perovskite X-ray detector operating in self-driven mode. The work highlights BMWO as a promising candidate for stable direct detection imaging and validates the material design strategy that leverages the large anisotropy of quasi-2D structures for sensitive and self-powered detection.","PeriodicalId":228,"journal":{"name":"Small","volume":"84 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defect-Engineered Luminescent Nanozyme with Enhanced Phosphohydrolase Activity for Degradation and Dual-Mode Detection of Paraoxon

IF 13.3 2区材料科学

Small Pub Date : 2025-01-21 DOI: 10.1002/smll.202409216

Xiaochen Liao, Bai Li, Li Wang, Yang Chen

{"title":"Defect-Engineered Luminescent Nanozyme with Enhanced Phosphohydrolase Activity for Degradation and Dual-Mode Detection of Paraoxon","authors":"Xiaochen Liao, Bai Li, Li Wang, Yang Chen","doi":"10.1002/smll.202409216","DOIUrl":"https://doi.org/10.1002/smll.202409216","url":null,"abstract":"The excessive use of organophosphorus pesticides poses a substantial threat to both human health and the environment. Consequently, there is an urgent need for new methods that can quickly degrade and sensitively detect these compounds. A versatile nanozyme based on the biomimetic principle is an effective strategy to solve this problem. In this study, a multifunctional luminescent nanozyme Eu@Ce/UiO-67 composed of Eu3+ and a bimetallic organic framework Ce/UiO-67 is developed for the degradation and dual-mode detection of paraoxon. The doping of Ce4+ results in the formation of more defective structures in Eu@Ce/UiO-67, which significantly enhances the phosphatase activity of Eu@Ce/UiO-67 and the degradation efficiency of paraoxon. The hydrolysis product 4-nitrophenol (4-NP) shows a distinct UV-vis absorption in the visible light region and can quench the fluorescence of Eu@Ce/UiO-67 by the effect of photo-induced electron transfer (PET), thus achieving dual-mode detection of paraoxon by colorimetric and fluorescent methods. This study provides a new idea for the simultaneous monitoring and degradation of organophosphorus pesticides, expanding the boundaries of “integration of diagnosis and treatment” for environmental pollutants.","PeriodicalId":228,"journal":{"name":"Small","volume":"77 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-Time Unsupervised Learning and Image Recognition via Memristive Neural Integrated Chip Based on Negative Differential Resistance of Electrochemical Metallization Cell Neuron Device

IF 13.3 2区材料科学

Small Pub Date : 2025-01-21 DOI: 10.1002/smll.202407612

Dae-Seong Woo, Jae-Kyeong Kim, Gwang-Ho Park, Woo-Guk Lee, Min-Jong Han, Soo-Min Jin, Tae-Hun Shim, Jae-Joon Kim, Jinsub Park, Jea-Gun Park

{"title":"Real-Time Unsupervised Learning and Image Recognition via Memristive Neural Integrated Chip Based on Negative Differential Resistance of Electrochemical Metallization Cell Neuron Device","authors":"Dae-Seong Woo, Jae-Kyeong Kim, Gwang-Ho Park, Woo-Guk Lee, Min-Jong Han, Soo-Min Jin, Tae-Hun Shim, Jae-Joon Kim, Jinsub Park, Jea-Gun Park","doi":"10.1002/smll.202407612","DOIUrl":"https://doi.org/10.1002/smll.202407612","url":null,"abstract":"Spiking neurons are essential for building energy-efficient biomimetic spatiotemporal systems because they communicate with other neurons using sparse and binary signals. However, the achievable high density of artificial neurons having a capacitor for emulating the integrate function of biological neurons has a limit. Furthermore, a low-voltage operation (<1.0 V) is essential for connecting with modern complementary metal-oxide-semiconductor-field-effect-transistor-based (C-MOSFET—based) integrated circuits. Here, a capacitorless memristive-neural integrated chip (MnIC) based on the negative differential resistance of the electrochemical metallization cell designed using a 28-nm C-MOSFET process in a foundry is reported. The fabricated MnIC exhibits extremely low-voltage operation (<0.7 V) via the rupture dynamics of Ag filaments formed in the GeS2 chalcogenide layer, with a nonlinear increase in the action potential in a manner similar to a human sensory system. Moreover, to construct a fully-structured spiking neural network (SNN), an oxygenated amorphous carbon-based (α-COx-based) synaptic device having 32 multi-level conductance states is designed. The designed MnIC and α-COx-based synaptic device demonstrate real-time unsupervised learning via a spike-timing-dependent plasticity learning rule with an SNN. Using the trained SNN, the real-time hand-written digit image of a cell phone obtained from a live webcam is successfully classified, which suggests practical applications for brain-like neuromorphic chips.","PeriodicalId":228,"journal":{"name":"Small","volume":"137 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Interfacial Interactions Through Microwave-Irradiated Reduction for the Recycling of Photovoltaic Silicon Waste for Lithium Storage

IF 13.3 2区材料科学

Small Pub Date : 2025-01-21 DOI: 10.1002/smll.202410899

Jie Zhou, Chunling She, Yan Liu, Yawen Li, Wangbing Yao, Zhuoyuan Zheng, Yusong Zhu

{"title":"Enhancing Interfacial Interactions Through Microwave-Irradiated Reduction for the Recycling of Photovoltaic Silicon Waste for Lithium Storage","authors":"Jie Zhou, Chunling She, Yan Liu, Yawen Li, Wangbing Yao, Zhuoyuan Zheng, Yusong Zhu","doi":"10.1002/smll.202410899","DOIUrl":"https://doi.org/10.1002/smll.202410899","url":null,"abstract":"The application of micro-nano size photovoltaic waste silicon (wSi) as an anode material for lithium-ion battery holds significant practical potential; However, it faces a series of challenges related to the volume expansion of Si during cycling. In this study, a simple, efficient, and eco-friendly microwave method is proposed for the rapid preparation of graphene-coated silicon materials (wSi@rGO) in just a few seconds, in which graphene as the stable interface mitigates structural failure caused by significant volume expansion, enhances electron and ion conductivity, inhibits undesirable side reactions between silicon and electrolyte, and promotes the stability of solid electrolyte interface (SEI). Importantly, the instantaneous high temperature generated by microwaves facilitates the formation of interfacial SiC chemical bonds, which strengthen the interaction between Si and graphene, thereby reducing Si delamination. The wSi@rGO anode exhibits remarkable cycling stability, maintaining a specific capacity of 1100 mA h g−1 over 250 cycles. Furthermore, the assembled wSi@rGO//LiFePO4 full battery demonstrates robust performance, retaining a stable capacity of 150 mA h g−1 after 80 cycles at 0.5 C. This research not only demonstrates a straightforward and efficient microwave technique for synthesizing wSi@rGO anode materials, but also offers an environmentally friendly and economical pathway for recycling photovoltaic waste silicon, contributing positively to carbon peaking and carbon neutrality.","PeriodicalId":228,"journal":{"name":"Small","volume":"380 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast-Charging High-Specific Lithium Metal Batteries Enabled by Oleophilic Garnet Suspension Electrolyte

IF 13.3 2区材料科学

Small Pub Date : 2025-01-21 DOI: 10.1002/smll.202412389

Shengxian Wang, Fengkun Wei, Anji Reddy Polu, Pramod K. Singh, Ning Hu, Shufeng Song

{"title":"Fast-Charging High-Specific Lithium Metal Batteries Enabled by Oleophilic Garnet Suspension Electrolyte","authors":"Shengxian Wang, Fengkun Wei, Anji Reddy Polu, Pramod K. Singh, Ning Hu, Shufeng Song","doi":"10.1002/smll.202412389","DOIUrl":"https://doi.org/10.1002/smll.202412389","url":null,"abstract":"Realizing fast charging in high-specific-energy lithium metal batteries (LMBs) remains a significant challenge. Here, a oleophilic garnet suspension electrolyte design is reported, using inorganic solid electrolyte modified by low-surface-energy 1H,1H,2H,2H-perfluorooctyl trichlorosilane (PFOTS), to address the dilemma of fast charging and high specific energy in LMBs. With the oleophilic suspension electrolytes, the ionic conductivity of carbonate electrolyte is increased by ≈20%. Importantly, Li+ transference number is increased by ≈50% (reaching 0.57). Furthermore, the oleophilic suspension electrolyte regulates the solid electrolyte interphase (SEI), resulting in improved Coulombic efficiency (from 98.9% to 99.5%) and decreased Li/electrolyte interfacial impedance (from 263 to 86.5 Ω). As a result, LMBs using LiNi0.8Co0.1Mn0.1O2 (NCM811) cathode and the oleophilic suspension electrolyte achieves a remarkable capacity retention of 81.7% at the 500th cycle under fast charging of 4 C rate. In the LMBs at high NCM811 loading of 18 mg cm−2, a cyclability of 89% capacity retention after 200 cycles along with limited increase in electrode overpotential is accomplished at a critical current density of 1.08 mA cm−2. The fast charging and remarkable cyclability are attributed to the enhancement of electrolyte transport capabilities and generation of a favorable solid electrolyte interphase at the Li surface.","PeriodicalId":228,"journal":{"name":"Small","volume":"206 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuning Fluorination of Carbon Molecular Sieve Membranes with Enhanced Reverse-Selective Hydrogen Separation From Helium

IF 13.3 2区材料科学

Small Pub Date : 2025-01-21 DOI: 10.1002/smll.202411664

Zeyuan Gao, Yongchao Sun, Lu Bai, Tianyou Li, Jianyu Guan, Fake Sun, Fangxu Fan, Gaohong He, Canghai Ma

{"title":"Tuning Fluorination of Carbon Molecular Sieve Membranes with Enhanced Reverse-Selective Hydrogen Separation From Helium","authors":"Zeyuan Gao, Yongchao Sun, Lu Bai, Tianyou Li, Jianyu Guan, Fake Sun, Fangxu Fan, Gaohong He, Canghai Ma","doi":"10.1002/smll.202411664","DOIUrl":"https://doi.org/10.1002/smll.202411664","url":null,"abstract":"Membrane technology has been explored for separating helium from hydrogen in natural gas reservoirs, a process that remains extremely challenging due to the sub-Ångstrom size difference between H2 and He molecules. Reverse-selective H2/He separation membranes offer multiple advantages over conventional helium-selective membranes, which, however, suffer from low H2/He selectivity. To address this hurdle, a novel approach is proposed to tune the ultra-micropores of carbon molecular sieves (CMS) membranes through fluorination of the polymer precursor. By incorporating -CF3 units into the backbone of Tröger's base polymers, the microporosity of CMS is tailored and reverse-selective H2/He CMS membranes are deployed with remarkable separation performance, surpassing most reported membranes. These CMS membranes exhibit a H2 permeability of 1505.2 Barrer with a notable H2/He selectivity of 3.8. Barometric sorption tests reveal preferential sorption of H2 over He in the fluorinated CMS membranes, which also demonstrate a significantly higher H2/He diffusion selectivity compared to unfluorinated samples. Material studio calculations indicate that the “slim” hydrogen molecule penetrates ultra-micropores more readily than the spherical He molecule, thus achieving reverse H2/He selectivity. This design approach offers a promising pathway for developing molecularly sieving membranes to tackle the challenging helium separation from natural gas.","PeriodicalId":228,"journal":{"name":"Small","volume":"59 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0