{"title":"Achieving Ultra‐Thin Solid Electrolyte Interphase for High‐Performance Lithium Metal Anodes via Chloride‐Assisted Electrochemical Corrosion","authors":"Xue Wang, Qiao Zhang, Zengwu Wei, Kaiwei Zhou, Xianhui Chen, Zhao Qian, Jun Wang, Xing Xin","doi":"10.1002/smll.202502682","DOIUrl":"https://doi.org/10.1002/smll.202502682","url":null,"abstract":"The thickness and composition of the solid electrolyte interphase (SEI) on lithium (Li) metal are critical factors influencing dendrite growth. This study introduces a novel electrolyte selection strategy based on electrochemical corrosion principles. By employing LiCl and LiNO<jats:sub>3</jats:sub> simultaneously, the electrolyte itself has a high donor number, low desolvation energy, high Li⁺ transference number and conductivity, and a moderate electrochemical stability window. In addition, it dynamically reduces the SEI thickness and reactivates dead Li, forming a ≈100 nm SEI enriched with LiF and Li<jats:sub>2</jats:sub>O on Li metal anode, which ensures the stable cycling of Li symmetric cells for 2000 h at a current density of 5 mA cm⁻<jats:sup>2</jats:sup>. Consequently, Li metal cells using LiFePO<jats:sub>4</jats:sub> (LFP) as the cathode with the LiNO<jats:sub>3</jats:sub>‐LiCl‐added electrolyte exhibit excellent cycling performance for 1600 cycles at 680 mA g⁻<jats:sup>1</jats:sup>. Even with a thin Li metal anode, the Li (5 µm)|LFP cell retains 95% capacity after 70 cycles at 170 mA g⁻<jats:sup>1</jats:sup>. The universality and feasibility of this electrolyte design are also validated in diverse battery chemistries such as anode‐free Cu|LFP, Li|LiNi<jats:sub>0.8</jats:sub>Mn<jats:sub>0.1</jats:sub>Co<jats:sub>0.1</jats:sub>O<jats:sub>2</jats:sub> (NMC811), and Li|S cells, as well as in pouch cells with high‐loading LFP and NMC811 cathodes, showcasing the promising electrolyte design strategy for Li metal batteries.","PeriodicalId":228,"journal":{"name":"Small","volume":"78 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling the Effect of Polymerization Values on the Crystallization Behavior of Perovskite Films for Efficient and Stable Solar Cells","authors":"Weijian Tang, Yu Chen, Ruisen Shi, Yihui Wu, Jingquan Zhang","doi":"10.1002/smll.202502851","DOIUrl":"https://doi.org/10.1002/smll.202502851","url":null,"abstract":"Obtaining high‐quality perovskite films is crucial for reducing non‐radiative recombination and improving device performance. As reported, the crystallization process of perovskite films can be effectively tailored by introducing multifunctional additives. In this work, polyvinyl pyrrolidone (PVP) with varying degrees of polymerization (DP) values (K15, K30, and K90) are systematically screened and utilized as an additive to regulate defect density and control the crystallization process of perovskite films. This regulation is achieved through coordination interactions between perovskites and their multi‐carbonyl groups of PVP. Among the selected polymers, the K30 carbonyl polymer exhibits a suitable viscosity and bind strength, which facilitated a significant delay in the intermediate phase transition and accelerated nucleation. As a result, high‐quality perovskite films with enhanced crystallinity, prolonged PL lifetime, and no residual PbI<jats:sub>2</jats:sub> are achieved. The K30‐treated MA‐free device demonstrated a PCE of 24.16% with a remarkable <jats:italic>V</jats:italic><jats:sub>OC</jats:sub> of 1.2 V. Moreover, this strategy can be extended to RbCsFAMA quadruple‐cation perovskite films, delivering an impressive PCE of 25.35% with a minimal <jats:italic>V</jats:italic><jats:sub>OC</jats:sub> deficit of 0.35 V. This work provides an effective approach to modulate the crystal growth of perovskite films and highlights the significance of the DP values for polymeric additives.","PeriodicalId":228,"journal":{"name":"Small","volume":"69 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hyperbranched Polyborophosphate towards Transparent Epoxy Resin with Ultrahigh Toughness and Fire Safety","authors":"Rui Liu, Yifeng Zhang, Wenyan Liu, Zhiyu Yu, Ruizhi Yu, Hongxia Yan","doi":"10.1002/smll.202502839","DOIUrl":"https://doi.org/10.1002/smll.202502839","url":null,"abstract":"Inherent transparency makes epoxy resins ideal for aircraft windows, yet their brittleness and flammability remain challenges. Existing strategies for these issues often compromise transparency, with limited research on the mechanisms involved. Herein, a novel strategy is proposed for fabricating transparent epoxy resin by tuning the electrostatic potential distribution via hyperbranched polyborophosphate. Electron‐deficient boron and relatively electron‐rich phosphorus atoms work synergistically to increase the highest occupied molecular orbital‐lowest unoccupied molecular orbital (HOMO‐LUMO) energy gap, preventing visible light absorption. Meanwhile, the hyperbranched structure facilitates polymer network interpenetration to reduce porosity for decreased light scattering. This synergy results in a nearly colorless material with over 80% transmittance at 550 nm even at 4 mm thickness, along with full‐band UV shielding. Notably, the material demonstrates a 114.7% increase in impact toughness (45.2 kJ m<jats:sup>−2</jats:sup>) due to dual dynamic B─O and P─O linkages. Besides, it yields a limiting oxygen index of 33% and a V0 rating in the underwriter laboratories vertical burning test, along with significant reductions in heat, smoke, and toxic gas release. The outstanding performance makes it stand out compared to reported advanced transparent epoxy resins, highlighting the significance of this work.","PeriodicalId":228,"journal":{"name":"Small","volume":"33 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SmallPub Date : 2025-04-25DOI: 10.1002/smll.202501322
Linlin Ma, Hanyun Yang, Wenting Yu, Ming Bai, Lepeng Zhou, Zhongjie Ren, Hongli Chen, Lei Zhang, Bin Xue, Wenxu Sun, Yi Cao
{"title":"Enhanced Mechanical Properties and Sensing Performance of MXene-Based Dual-Crosslinked Hydrogel via EGCG Coating and Dynamic Covalent Bond","authors":"Linlin Ma, Hanyun Yang, Wenting Yu, Ming Bai, Lepeng Zhou, Zhongjie Ren, Hongli Chen, Lei Zhang, Bin Xue, Wenxu Sun, Yi Cao","doi":"10.1002/smll.202501322","DOIUrl":"https://doi.org/10.1002/smll.202501322","url":null,"abstract":"MXenes hold great promise for flexible sensors due to their outstanding electrical and mechanical properties. However, their practical application in aqueous environments is often compromised by oxidation susceptibility. Here, epigallocatechin gallate (EGCG), a naturally derived compound is introduced, as a protective coating for Ti₃C₂T<sub>x</sub> MXene nanosheets. The catechol groups in EGCG form strong hydrogen bonds with MXene, significantly enhancing its oxidation resistance in aqueous environments for up to 40 days. By incorporating EGCG-coated MXene (MXene@EGCG) to form a dual-crosslinked hybrid network, a tough hydrogel with exceptional properties, including enhanced compressibility (>95%), high compressive strength (5.43 MPa), minimal residual strain (<1%), and rapid recovery within seconds is developed. Furthermore, the hydrogel exhibits superior sensing capabilities with a compressive gauge factor exceeding 10 and a stretch gauge factor of up to 3.72. This well-designed structure also endows it a low degree of hysteresis in compressive sensing. In vitro experiments confirm its great biocompatibility, desired self-adhesion properties, and practical utility as a sensing platform. This approach pioneers a versatile and transformative strategy for enhancing MXene stability and engineerability, unlocking new possibilities for fabricating high-performance hydrogel-based sensors capable of effectively sensing dynamic strains, which may find broad applications in the fields of multifunctional bioelectronics.","PeriodicalId":228,"journal":{"name":"Small","volume":"2 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SmallPub Date : 2025-04-25DOI: 10.1002/smll.202502142
Yifan Sun, Zongyu Wang, Jihua Chen, Zhennan Huang, Hanxin Fu, Miaofang Chi, Mark A. Arnould, Sheng Dai
{"title":"Radical Polymerization by Heterogeneous Ceria Nanocatalysts","authors":"Yifan Sun, Zongyu Wang, Jihua Chen, Zhennan Huang, Hanxin Fu, Miaofang Chi, Mark A. Arnould, Sheng Dai","doi":"10.1002/smll.202502142","DOIUrl":"https://doi.org/10.1002/smll.202502142","url":null,"abstract":"Heterogeneous catalysts for radical polymerization are desired due to advantageous recyclability, which facilitates further purification and various applications. Herein, colloidal ceria (CeO<sub>2</sub>) nanocrystals function as an efficient heterogeneous catalyst driving radical polymerization of methyl methacrylate (MMA). Enrichment of Ce<sup>3+</sup> is observed on the CeO<sub>2</sub> surface upon polymerization, revealing a surface-mediated redox mechanism underpinned by the reversible formation of oxygen defects. The heterogeneous polymerization pathway is further extended to the preparation of SiO<sub>2</sub>-grafted-PMMA particle brushes, which demonstrates the potential to access polymeric composite materials. The study provides an effective heterogeneous route to catalyzing radical polymerization that has been routinely realized with homogeneous catalysis. A wider scope of reducible metal oxides is anticipated to be explored, where compelling recyclability and tunable reactivities can be attained.","PeriodicalId":228,"journal":{"name":"Small","volume":"45 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alkylammonium Salt as Additives to Expand the Processing Window of Wide-Bandgap Perovskite Solar Cells Made in Ambient Air","authors":"Jing Lv, Jilin Wang, Yuanhang Cheng, Jiaonan Sun, Menglan Lv, Ke Jin, Fei Long, Aurora Rizzo, Feng Hao, Keyou Yan, Jingjing Chang, Chenyi Yi, Junqiao Ding, Yong Ding, Chuantian Zuo, Liming Ding","doi":"10.1002/smll.202503214","DOIUrl":"https://doi.org/10.1002/smll.202503214","url":null,"abstract":"Wide-bandgap (WBG) perovskites are critical for advancing tandem solar cell technology, yet their fabrication remains constrained by narrow processing windows and environmental instability. A synergistic alkylammonium salt additive strategy coupled with a mild gas-flow-assisted crystallization method is presented to produce ambient-air-processed WBG perovskite solar cells (PSCs) with improved reproducibility and scalability. Co-utilizing long-chain alkylammonium chlorides (xACls) and methylammonium chloride (MACl) reduced gas-flow speed requirements while expanding the crystallization kinetics window, suppressing non-radiative recombination and defects, which are verified by fluorescence lifetime imaging microscopy (FLIM), in situ UV–vis spectroscopy, and XRD. High-quality Cs<sub>0.2</sub>FA<sub>0.8</sub>PbI<sub>2.3</sub>Br<sub>0.7</sub> films are successfully prepared under a low gas flow speed (≈2.7 m s<sup>−1</sup>), which is much lower than the traditional gas quenching method (>26 m s<sup>−1</sup>). Cs<sub>0.2</sub>FA<sub>0.8</sub>PbI<sub>2.3</sub>Br<sub>0.7</sub> solar cells made by using 12ACl/MACl additives yielded a champion power conversion efficiency (PCE) of 19.72% (<i>V</i><sub>oc</sub>: 1.238 V), which is among the highest efficiency for WBG PSCs made in ambient air. This method has the advantages of high humidity tolerance (PCE >19% for cells made under 20–65% RH), compatibility with cost-effective fan drying, elimination of anti-solvents, and >70% inert gas-flow intensity reduction, establishing an eco-friendly scalable protocol that bridges lab-to-industry translation for high-performance WBG PSCs.","PeriodicalId":228,"journal":{"name":"Small","volume":"14 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SmallPub Date : 2025-04-25DOI: 10.1002/smll.202502158
Zirui Qin, Lei Jiao, Lijun Hu, Yiming Zhang, Xiangkun Jia, Chengjie Chen, Xiaolei Sun, Yanling Zhai, Zhijun Zhu, Xiaoquan Lu
{"title":"Amorphous RuO2 Nanozymes with an Excellent Catalytic Efficiency Superior to Natural Peroxidases","authors":"Zirui Qin, Lei Jiao, Lijun Hu, Yiming Zhang, Xiangkun Jia, Chengjie Chen, Xiaolei Sun, Yanling Zhai, Zhijun Zhu, Xiaoquan Lu","doi":"10.1002/smll.202502158","DOIUrl":"https://doi.org/10.1002/smll.202502158","url":null,"abstract":"Developing efficient peroxidase-like nanozymes to surpass natural enzymes remains a significant challenge. Herein, an amorphous RuO<sub>2</sub> nanozyme with peroxidase-like activity is synthesized for activating H<sub>2</sub>O<sub>2</sub> with a specific activity of 1492.52 U mg<sup>−1</sup>, outperforming the crystalline RuO<sub>2</sub> nanozymes by a factor of 22 and far superior to natural peroxidases. Amorphous RuO<sub>2</sub> nanozymes with long-range disordered atomic arrangements can effectively elongate the O─O bonds in H<sub>2</sub>O<sub>2</sub>. Abundant oxygen vacancies in amorphous RuO<sub>2</sub> nanozymes lead to an upshift of the <i>d</i>-band center, enhancing the exceptional adsorption strength of H<sub>2</sub>O<sub>2</sub>, which improve the electron transfer efficiency and ensure superior peroxidase-like activity. Accordingly, a nanozyme-linked immunosorbent assay is developed for the precise and sensitive detection of prostate-specific antigens with a detection limit as low as 0.52 pg mL<sup>−1</sup>. This study introduces a simple approach for developing high-performance peroxidase-like nanozymes to improve the analytical performances of prostate-specific antigens in clinical diagnostics.","PeriodicalId":228,"journal":{"name":"Small","volume":"33 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SmallPub Date : 2025-04-25DOI: 10.1002/smll.202408462
Paul E. Savas, Zhe Yuan, Nghi La, Weiyin Chen, Xu Wang, Xiaowei Wu, Thomas B Malloy, Praveen Bollini, James M. Tour
{"title":"Incomplete CO2 Desorption Enhances O2 Stability of Solid Amine Carbon Capture Sorbents","authors":"Paul E. Savas, Zhe Yuan, Nghi La, Weiyin Chen, Xu Wang, Xiaowei Wu, Thomas B Malloy, Praveen Bollini, James M. Tour","doi":"10.1002/smll.202408462","DOIUrl":"https://doi.org/10.1002/smll.202408462","url":null,"abstract":"Reducing carbon dioxide (CO<sub>2</sub>) emissions is a critical environmental challenge. Capturing CO<sub>2</sub> by solid polyethylenimine (PEI) sorbents is proposed as a strategy to address this concern. The CO<sub>2</sub> forms carbamates with the amine groups on the solid sorbent. However, solid PEI sorbents are unstable under O<sub>2</sub>-containing flue gas streams, a property that has greatly limited their industrial importance. To combat this O<sub>2</sub>-sensitivity, the amount of CO<sub>2</sub> desorbed per cycle is reduced to protect amines by the formed carbamates. These carbamates sufficiently reduce oxidative cleavage and maintain a low k<sub>deac</sub> of −0.00373 cycle<sup>−1</sup> while maintaining a working capacity of 2.88 wt% (0.65 mmol g<sup>−1</sup>) under an O<sub>2</sub>-containing gas mixture. Additionally, it is discovered that the degradation rate can be tuned through adjusting the sorbent working capacity; this tunability can be used to inform future process simulations. This approach offers an additive-free pathway toward oxidatively stable PEI carbon capture sorbents.","PeriodicalId":228,"journal":{"name":"Small","volume":"56 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Polymer-Encapsulated Catalase for Targeted Redox Regulation in Acute Liver Injury","authors":"Feifei Li, Sai Gao, Rui Ma, Yijia Zhang, Yuxi Li, Dingqi Wu, Zeren Han, Qian Li, Qian He, Jiarui Li, Qiong Dai, An-Ding Xu, Liyun Zhang, Chaoyong Liu, Yunfeng Lu","doi":"10.1002/smll.202412349","DOIUrl":"https://doi.org/10.1002/smll.202412349","url":null,"abstract":"The liver plays a critical role in maintaining homeostasis, and its dysfunction can lead to severe conditions like acute liver injury (ALI), which is primarily caused by viral infections, toxins, and oxidative stress. Reactive oxygen species (ROS), especially hydrogen peroxide (H₂O₂), significantly drive hepatocyte injury, initiating oxidative stress and inflammation. Current antioxidants, such as N-acetylcysteine (NAC) and superoxide dismutase (SOD), show limited clinical efficacy due to poor targeting, instability, and toxicity. Catalase (CAT), an essential enzyme for H₂O₂ decomposition, represents a promising therapeutic for ALI; however, its clinical application faces challenges in stability, rapid degradation, and insufficient targeting. Here, a novel nanocapsule-based CAT delivery system (n(CAT)) is presented, formed through in situ radical polymerization using 2-methacryloyloxyethyl phosphorylcholine (MPC) and N-(3-aminopropyl)-methacrylamide hydrochloride (APM). This strategy significantly enhances CAT's stability, retains enzyme activity, and improves selective liver accumulation, particularly at inflammation sites. The results demonstrate that n(CAT) effectively reduces oxidative stress, minimizes inflammation, and facilitates liver repair in ALI and ischemia-reperfusion injury (IRI) models. These findings highlight the potential of n(CAT) as a promising platform for advanced antioxidant therapies targeting liver diseases, including hepatitis.","PeriodicalId":228,"journal":{"name":"Small","volume":"34 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SmallPub Date : 2025-04-25DOI: 10.1002/smll.202502490
Johann M. Weck, Riya Nair, Merve-Z. Kesici, Xiaoyue Shang, Svetozar Gavrilović, Cornelia Monzel, Amelie Heuer-Jungemann
{"title":"Effects of DNA Origami-Based Nanoagent Design on Apoptosis Induction in a Large 3D Cancer Spheroid Model","authors":"Johann M. Weck, Riya Nair, Merve-Z. Kesici, Xiaoyue Shang, Svetozar Gavrilović, Cornelia Monzel, Amelie Heuer-Jungemann","doi":"10.1002/smll.202502490","DOIUrl":"https://doi.org/10.1002/smll.202502490","url":null,"abstract":"DNA origami offers highly accurate control over shape and addressability on the nanoscale. This precise control makes it highly valuable in various fields, particularly precision nanotherapeutics. For cancer treatment, the extrinsic activation of programmed cell death by Fas receptor (FasR)/CD95-based nanoagents is a promising, minimally invasive strategy. However, treating large, solid tumors poses challenges for the design of DNA origami-based therapeutics, including drug distribution and altered cellular behavior. Here, these challenges are addressed by establishing design principles for nanoagents and testing them in a 3D cancer spheroid model. First, the ability of DNA origami nanostructures are assessed to penetrate large cancer spheroids, finding that penetration is influenced by the DNA origami size rather than its structural flexibility. Second, the capability of FasL-DNA origami-based nanoagents are evaluated to induce apoptosis in cancer spheroids, representing a more biologically relevant environment, compared to 2D studies. It is found that apoptosis induction is primarily determined by the FasL attachment strategy rather than the underlying DNA origami structure. The most effective nanoagents constructed in this study halted spheroid growth and eradicated all cancer cells within the spheroids. This study offers important insights into critical design considerations for DNA-based therapeutics for complex cellular environments, advancing DNA origami nanotherapeutic development.","PeriodicalId":228,"journal":{"name":"Small","volume":"74 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}