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A Double-Gradient All-Organic Dielectric Polymer Film Achieving Superior Breakdown Strength and Energy Density

IF 13.3 2区材料科学

Small Pub Date : 2025-02-21 DOI: 10.1002/smll.202411304

Yang Liu, Guo Tian, Yue Sun, Shenglong Wang, Longchao Huang, Xuelan Li, Tianpei Xu, Long Jin, Yulin Zou, Weili Deng, Weiqing Yang

{"title":"A Double-Gradient All-Organic Dielectric Polymer Film Achieving Superior Breakdown Strength and Energy Density","authors":"Yang Liu, Guo Tian, Yue Sun, Shenglong Wang, Longchao Huang, Xuelan Li, Tianpei Xu, Long Jin, Yulin Zou, Weili Deng, Weiqing Yang","doi":"10.1002/smll.202411304","DOIUrl":"https://doi.org/10.1002/smll.202411304","url":null,"abstract":"Ferroelectric polymers have drawn tremendous attention in film capacitors owing to their high permittivity and ease of processing. Nevertheless, the energy density of such materials is severely constrained due to inferior breakdown strength. To address this dilemma, a double-gradient multilayered all-organic dielectric composite film is proposed, fabricated via a simple layer-by-layer solution-casting process. The experimental results demonstrate that the composite film significantly suppresses the leakage current compared to the pristine films, resulting in remarkable enhancement of the insulation properties. The finite element simulation results further reveal that the optimized electric field distribution induced by the gradient structure and the carrier traps at the interfaces between the adjacent layers play a crucial role in impeding the propagation of the breakdown path. As a result, the developed dielectric film reaches an unexpected breakdown strength of 712 MV m−1 along with a high energy density of 19.68 J cm−3, surpassing the bench-mark biaxially oriented polypropylene as well as the existing ferroelectric-based composites reported in the recent works. The synergy of gradient and multilayered structure presented in this work offers a novel perspective and approach for the scalable fabrication of dielectric films with eminent capacitive performance.","PeriodicalId":228,"journal":{"name":"Small","volume":"86 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Oleylamine-Directed Nano-OZIF-67 Induced Microporous Carbon Nanofiber Conjugated with Tiny Fibrous PEDOT Polymer for Hybrid-Capacitor Electrodes

IF 13.3 2区材料科学

Small Pub Date : 2025-02-21 DOI: 10.1002/smll.202408899

Sampath Karingula, Shekher Kummari, Yugender Goud Kotagiri, Latha Malyala, K. Vengatajalabathy Gobi

{"title":"Development of Oleylamine-Directed Nano-OZIF-67 Induced Microporous Carbon Nanofiber Conjugated with Tiny Fibrous PEDOT Polymer for Hybrid-Capacitor Electrodes","authors":"Sampath Karingula, Shekher Kummari, Yugender Goud Kotagiri, Latha Malyala, K. Vengatajalabathy Gobi","doi":"10.1002/smll.202408899","DOIUrl":"https://doi.org/10.1002/smll.202408899","url":null,"abstract":"Making nanostructured metal oxides intertwined with graphitic carbon materials is critically important to construct hybrid supercapacitors with high-performance, cost-affordable, and free-standing 1D hybrid electrode material and is of foremost importance to responding positively to the impending energy crisis. Fine-tuned nano-sized ZIF-67 particles of 5 – 25 nm width (OZIF-67) are achieved using oleylamine-involved synthesis and are seeded into fibrous poly-PAN-PVP. Porous N-doped carbon nanofibers impregnated with OZIF-67-derived Co3O4 (oz-Co3O4-PNCNF) are obtained by calcining the electrospun polymer. The surface area of oz-Co3O4-PNCNF is exceptionally high, 429 m2 g−1, with the pore size predominantly ≈2 – 5 nm. Thin conducting polymer films of poly-(3,4-ethylenedioxythiophene) are formed onto oz-Co3O4-PNCNF (oz-Co3O4-PNCNF/PEDOT). A porous, long nanofibrous structure (≈100 nm thick) of oz-Co3O4-PNCNF and a spongy needle-like network of PEDOT interconnecting outer layers are established from FESEM images. The material has shown excellent energy storage capability with the specific capacitance (CS) of 417 F g−1 (oz-Co3O4-PNCNF/PEDOT). Free-standing supercapacitor device delivers excellent performance in asymmetric assembly (oz-Co3O4-PNCNF/PEDOT//PNCNF) with 141.1 Wh kg−1 and 84% CS at the end of 5000 charge–discharge cycles. The excellent porous network, combined with finely-tuned nano-sized Co3O4 particles and an overlying thin electropolymer film, work together to establish high energy, efficient, and stable supercapacitors.","PeriodicalId":228,"journal":{"name":"Small","volume":"24 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Composition and Surface Engineering of Ruthenium-Cobalt Hydroxide Nanowires for Efficient Oxygen Evolution Catalysis

IF 13.3 2区材料科学

Small Pub Date : 2025-02-21 DOI: 10.1002/smll.202409151

Young Jun Jang, Jungwoo Choi, Jun Hwan Moon, Hyuck Mo Lee, Young Keun Kim

{"title":"Synergistic Composition and Surface Engineering of Ruthenium-Cobalt Hydroxide Nanowires for Efficient Oxygen Evolution Catalysis","authors":"Young Jun Jang, Jungwoo Choi, Jun Hwan Moon, Hyuck Mo Lee, Young Keun Kim","doi":"10.1002/smll.202409151","DOIUrl":"https://doi.org/10.1002/smll.202409151","url":null,"abstract":"Developing efficient electrocatalysts that improve the rate-determining step (RDS) kinetics is crucial to addressing the kinetically sluggish oxygen evolution reaction (OER). This study introduces ruthenium (Ru)-cobalt(II) hydroxide (Co(OH)₂) electrocatalysts for high-performance OER by combining compositional and thermodynamic surface engineering. Density functional theory (DFT) is employed to identify the ideal composition, with experimental validation conducted through electrodeposition, enabling facile control over a wide range of compositions for nanowire catalyst synthesis. Pourbaix diagram analysis helps establish precise synthesis conditions for developing surface nanostructures. The optimized Ru-Co(OH)₂ catalyst demonstrates exceptional performance, achieving overpotentials of 189 mV at 10 mA cm⁻2 and 292 mV at 50 mA cm⁻2, significantly outperforming other compositions. The exceptional electrocatalytic performance can be attributed to two key factors: strengthened OH adsorption energy due to optimal composition, which lowers the energy barrier of the rate-determining step in the OER, and increased specific surface area resulting from surface nanostructure formation.","PeriodicalId":228,"journal":{"name":"Small","volume":"10 6 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Making Synthetic 2D Graphene Oxide Nanosheets by Electrochemical Oxidation of Commercial Carbon Fibres

IF 13.3 2区材料科学

Small Pub Date : 2025-02-21 DOI: 10.1002/smll.202408972

Alba Español, Anton Bjurström, Björn Birdsong, Fritjof Nilsson, Annu Pandey, Xiaojun Ren, Rakesh Joshi, Stefano Farris, Richard T Olsson

{"title":"Making Synthetic 2D Graphene Oxide Nanosheets by Electrochemical Oxidation of Commercial Carbon Fibres","authors":"Alba Español, Anton Bjurström, Björn Birdsong, Fritjof Nilsson, Annu Pandey, Xiaojun Ren, Rakesh Joshi, Stefano Farris, Richard T Olsson","doi":"10.1002/smll.202408972","DOIUrl":"https://doi.org/10.1002/smll.202408972","url":null,"abstract":"The study demonstrates a scalable and reproducible method for synthesising graphene oxide (GO) nanosheets from commercial carbon fibres derived from carbonised polyacrylonitrile (PAN) polymer. An exfoliation route with nitric acid allows for the preparation of monolayer GO nanosheets with a consistent thickness of 0.9 ± 0.2 nm, identical to the commercially available GO from mined graphite. The GO nanosheets exhibit distinct circular and elliptical shapes, in contrast to the polygonal and sharp-edged morphology of commercial GO. An extensive evaluation of acidic solutions and electrical potentials identified a narrow processing window critical for obtaining GO nanosheets sized 0.1–1 µm. An unexpectedly low 5% acid concentration was found to be the most effective, providing a balance between efficient exfoliation through synergistic acidic and electrochemical oxidation. The process provides a high yield of 200 mg of GO per gram of carbon fibre. Advanced characterisation using high-resolution electron and atomic force microscopy (HR-TEM/SEM/AFM), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and infrared spectroscopy (FTIR) provided detailed insights into the morphology, thickness, surface functionalisation, and chemical composition of the nanosheets. With its high yield, environmentally sound production, and versatility, the synthesised GO offers transformative potential for large-scale applications, including energy storage, advanced coatings, high-performance composites, water purification, and electronic devices.","PeriodicalId":228,"journal":{"name":"Small","volume":"25 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promoting Efficient Ruthenium Sites With Lewis Acid Oxide for the Accelerated Hydrogen and Chlor-Alkali Co-Production

IF 13.3 2区材料科学

Small Pub Date : 2025-02-21 DOI: 10.1002/smll.202412123

Xiumin Gu, Zijian Li, Haeseong Jang, Jiachen Tang, Chaoyue Sun, Min Gyu Kim, Shangguo Liu, Xien Liu, Liqiang Hou

{"title":"Promoting Efficient Ruthenium Sites With Lewis Acid Oxide for the Accelerated Hydrogen and Chlor-Alkali Co-Production","authors":"Xiumin Gu, Zijian Li, Haeseong Jang, Jiachen Tang, Chaoyue Sun, Min Gyu Kim, Shangguo Liu, Xien Liu, Liqiang Hou","doi":"10.1002/smll.202412123","DOIUrl":"https://doi.org/10.1002/smll.202412123","url":null,"abstract":"Ruthenium (Ru) –based catalysts have been considered a promising candidate for efficient sustainable hydrogen and chlor-alkali co-production. Theoretical calculations have disclosed that the hollow sites on the Ru surface have strong adsorption energies of H and Cl species, which inevitably leads to poor activity for cathodic hydrogen evolution reaction (HER) and anodic chlorine evolution reaction (CER), respectively. Furthermore, it have confirmed that anchoring Lewis acid oxide nanoparticles such as MgO on the Ru surface can induce the formation of the onion-like charge distribution of Ru atoms around MgO nanoparticles, thereby exposing the Ru-bridge sites at the interface as excellent H and Cl adsorption sites to accelerate both HER and CER. Under the guidance of theoretical calculations, a novel dispersed MgO nanoparticles on Ru (MgOx-Ru) electrocatalyst is successfully prepared. In strongly alkaline and saline media, MgOx-Ru recorded excellent HER and CER electrocatalytic activity with a very low overpotential of 19 mV and 74 mV at the current density of 10 mA cm−2, respectively. More stirringly, the electrochemical test with MgOx-Ru as both anodic and cathodic electrodes under simulated chlor-alkali electrolysis conditions demonstrated superior electrocatalytic performance to the industrial catalysts of commercial 20 wt% Pt/C and dimensionally stable anode (DSA).","PeriodicalId":228,"journal":{"name":"Small","volume":"80 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid/ZIF-8 Biocomposites Based on Liposomes or Vesicles: In Situ Formation, and Preliminary Evaluation as Delivery Vehicles for Hydrophobic Drugs

IF 13.3 2区材料科学

Small Pub Date : 2025-02-21 DOI: 10.1002/smll.202407051

Mary Cano-Sarabia, Funda Aydin, Lingxin Meng, Marta Gil-Bonillo, Javier Fonseca, Manuela Dietrich, Simon Renner, Heinz Amenitsch, Paolo Falcaro, Inhar Imaz, Daniel Maspoch

{"title":"Lipid/ZIF-8 Biocomposites Based on Liposomes or Vesicles: In Situ Formation, and Preliminary Evaluation as Delivery Vehicles for Hydrophobic Drugs","authors":"Mary Cano-Sarabia, Funda Aydin, Lingxin Meng, Marta Gil-Bonillo, Javier Fonseca, Manuela Dietrich, Simon Renner, Heinz Amenitsch, Paolo Falcaro, Inhar Imaz, Daniel Maspoch","doi":"10.1002/smll.202407051","DOIUrl":"https://doi.org/10.1002/smll.202407051","url":null,"abstract":"Integrating lipid self-assemblies with metal-organic frameworks (MOFs) creates biocomposites ideal for encapsulation, protection, and delivery of functional species. This can be achieved using preformed MOFs or through in situ MOF formation. Herein, the one-pot formation of ZIF-8 MOF particles in the presence of two lipid self-assemblies (vesicles or liposomes) is reported, generating two types of hybrid lipid/ZIF-8 biocomposites. Each lipid assembly can be used to encapsulate hydrophobic actives into the hybrid lipid/ZIF-8 biocomposites, demonstrated with Nile Red and Astaxanthin (ATX) as representative cargo. In vitro digestion of ATX-loaded hybrid lipid/ZIF-8 particles in simulated intestinal fluid (SIF) shows distinct release kinetics: liposome-based particles offer a more sustained release compared to vesicle-based biocomposites. Intriguingly, in various media (water, simulated gastric fluid, bicarbonate, and SIF), the sodalite ZIF-8 topology in liposome-based lipid/ZIF-8 particles undergoes a crystalline phase transition to the denser, more-stable phase ZIF-C. This phase transition, along with a deeper internalization of ATX in liposome-based particles, accounts for the differences in release kinetics. In summary, the study provides valuable insights for the synthesis of hybrid lipid/ZIF-8 biocomposites, the encapsulation of hydrophobic molecules, the importance of investigating potential crystalline phase transitions of MOFs in different media, and their potential as drug delivery vehicles.","PeriodicalId":228,"journal":{"name":"Small","volume":"89 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microstructure Manipulation Achieves Superior Efficiency of GeTe-Based Thermoelectric Modules

IF 13.3 2区材料科学

Small Pub Date : 2025-02-21 DOI: 10.1002/smll.202500333

Qianqian Sun, Kaiyi Chen, Xiaojian Tan, Hongtao Li, Guangjie Wu, Zhe Guo, Jianfeng Cai, Guo-Qiang Liu, Jiehua Wu, Jun Jiang

{"title":"Microstructure Manipulation Achieves Superior Efficiency of GeTe-Based Thermoelectric Modules","authors":"Qianqian Sun, Kaiyi Chen, Xiaojian Tan, Hongtao Li, Guangjie Wu, Zhe Guo, Jianfeng Cai, Guo-Qiang Liu, Jiehua Wu, Jun Jiang","doi":"10.1002/smll.202500333","DOIUrl":"https://doi.org/10.1002/smll.202500333","url":null,"abstract":"GeTe has good thermoelectric performance at relatively high temperatures, but the low-symmetry structure near room temperature and phase transition limit its service stability for power generation applications. Here, the thermoelectric properties and mechanical hardness of GeTe are improved by microstructure manipulation and phase transition engineering. The incorporation of Cr, Pb, and Sb into the GeTe lattice modulates the phase transition, increasing the cubic phase fraction from 49% to 73% at 300 K. These modifications introduce shear strains and refined herringbone structures, enhancing phonon scattering while simultaneously improving carrier mobility through dislocation accumulation and band convergence. Consequently, the optimal materials achieve a maximum zT of 2.1 at 700 K and an average zT of 1.5 across the 300–773 K temperature range, along with a Vickers hardness of 1.88 GPa. Paired with n-type PbTe, the fabricated seven-pair module achieves a superior efficiency of 9.7% under a 500 K temperature gradient. This study demonstrates microstructure manipulation is a promising strategy for GeTe-based thermoelectric applications.","PeriodicalId":228,"journal":{"name":"Small","volume":"25 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in Chemical Vapor Deposited Carbon Films for Secondary Battery Applications

IF 13.3 2区材料科学

Small Pub Date : 2025-02-21 DOI: 10.1002/smll.202410570

Jiwoo Kim, Young-Wook Cho, Sang-Gil Woo, Je-Nam Lee, Gwan-Hyoung Lee

{"title":"Advancements in Chemical Vapor Deposited Carbon Films for Secondary Battery Applications","authors":"Jiwoo Kim, Young-Wook Cho, Sang-Gil Woo, Je-Nam Lee, Gwan-Hyoung Lee","doi":"10.1002/smll.202410570","DOIUrl":"https://doi.org/10.1002/smll.202410570","url":null,"abstract":"Carbon films, synthesized via chemical vapor deposition (CVD), have gained significant attention in secondary battery applications, where stability and capacity are required to be improved for next-generation electronic devices and electric vehicles. Beyond the inherent properties of carbon films, such as high electrical conductivity, mechanical strength, chemical stability, and flexibility, the CVD method provides a high degree of freedom in designing the carbon films in battery applications, enabling conformal coating with structure engineering for modification of its electrical and mechanical properties. In this review, the CVD-grown carbon films are highlighted in the secondary battery applications, enabling them to overcome critical issues, such as volume expansion, sluggish kinetics, and unstable interfaces. To deeply understand the CVD-grown carbon films, such as graphene and amorphous carbon, a comprehensive overview of the CVD process is also provided, focusing on growth mechanisms, control of 3D morphology, and doping techniques. In addition, a broad range of applications are introduced for carbon films in battery components, including their use in cathodes, anodes, and current collectors, as well as their potential in advanced battery systems, such as lithium-sulfur and all-solid-state batteries. This review proposes future directions for optimizing carbon films to achieve practical applications in next-generation energy storage devices.","PeriodicalId":228,"journal":{"name":"Small","volume":"13 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bulk Magnetic Properties Arise from Micron-Sized Supraparticle Interactions and Can be Modified on the Nanoscale

IF 13.3 2区材料科学

Small Pub Date : 2025-02-21 DOI: 10.1002/smll.202412311

Andreas Wolf, Markus Heinlein, Noah Kent, Stephan Müssig, Karl Mandel

{"title":"Bulk Magnetic Properties Arise from Micron-Sized Supraparticle Interactions and Can be Modified on the Nanoscale","authors":"Andreas Wolf, Markus Heinlein, Noah Kent, Stephan Müssig, Karl Mandel","doi":"10.1002/smll.202412311","DOIUrl":"https://doi.org/10.1002/smll.202412311","url":null,"abstract":"Magnetic supraparticles (SPs) can be employed as micron-sized particulate additives in arbitrary objects to serve as ID-tag or recorder of environmental triggers. Combined with magnetic particle spectroscopy (MPS), which enables read-out of the magnetic information in ambient conditions within seconds, magnetic SPs represent a powerful approach to equip materials with information. The encoded information relies on magnetic interactions within the SPs (intra-SP interactions) of chosen nanoparticles (NPs). However, possible magnetic interactions between SPs (inter-SP interactions), that might alter the MPS signal as well, have been neglected so far. Herein, it is elucidated that significant inter-SP interactions exist and that they can be tailored via adjustments in the SP structure, i.e., by defined adjustments of their intra-interaction as revealed by 3D-MuMax simulations and experiments in viscous fluids. Superparamagnetic iron oxide nanoparticle-based SP powders with strong inter-SP interactions exhibit significantly different MPS signals compared to their state after being incorporated into a matrix. Powders with weak inter-SP interactions (achieved by integration of non-magnetic SiO2 nanoparticles) show almost no signal change before and after incorporation. Both extremes of inter-SP interactions can be beneficial for various application scenarios and can be tailored on the nano-scale due to the interdependency of intra- and inter-SP interactions.","PeriodicalId":228,"journal":{"name":"Small","volume":"85 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Synergistic Effects of Phototherapy-Based NIR-II Absorption Photosensitizer for Allergic Rhinitis

IF 13.3 2区材料科学

Small Pub Date : 2025-02-21 DOI: 10.1002/smll.202412249

Tao Shao, Lu Han, Yang Xie, Zhenxiong Shi, Qilong Yang, Aojie Liu, Yi Liu, Langlang Chen, Jingman Huang, Bo Peng, Hua Bai, Hongli Chen, Lin Li, Ka Bian

{"title":"Bilateral Synergistic Effects of Phototherapy-Based NIR-II Absorption Photosensitizer for Allergic Rhinitis","authors":"Tao Shao, Lu Han, Yang Xie, Zhenxiong Shi, Qilong Yang, Aojie Liu, Yi Liu, Langlang Chen, Jingman Huang, Bo Peng, Hua Bai, Hongli Chen, Lin Li, Ka Bian","doi":"10.1002/smll.202412249","DOIUrl":"https://doi.org/10.1002/smll.202412249","url":null,"abstract":"Allergic rhinitis (AR) is the most prevalent global health issue, affecting approximately 3 billion people, with its incidence increasing annually. The current first-line pharmacotherapy for symptom relief has limited efficacy and often results in notable side effects. Here, aza-BODIPY-based nanoparticles (RH@NPs) are developed that exhibit mild photothermal therapy (PTT) and type I photodynamic therapy (PDT) capabilities. Enhanced intramolecular charge transfer induces NIR-II absorption of the photosensitizer (RH), facilitating deeper tissue penetration for augmented AR therapy. Additionally, the use of an asymmetric donor–acceptor–acceptor′ configuration promotes the self-assembly of RH, enhancing its intersystem crossing ability and enabling efficient photophysical activity. The synergistic effects of PTT (enhancing HSF1 DNA-binding activity to inhibit epithelial-mesenchymal transition by epigenetically regulating the expression of epithelial-mesenchymal transition-associated genes) and PDT (activating NRF2 transcriptional activity to stimulate the antioxidant defense system) enable RH@NPs to provide a superior therapeutic effect in a mouse model of AR. This effect is achieved by mechanically reducing the allergic response rather than merely alleviating symptoms. Notably, the photosensitizer-based physical therapy demonstrates enhanced safety. This study is the first to successfully investigate the application of phototherapy for AR and elucidate its mechanism of action, offering a novel, straightforward, and efficient treatment strategy for AR.","PeriodicalId":228,"journal":{"name":"Small","volume":"31 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0