IF 13.3 2区材料科学

Small Pub Date : 2025-08-01 DOI: 10.1002/smll.202409664

Ye Zhang, Kuo Zhang, Ling Xu, Xinmin Lu, Ping Hu, Jinyi Long, Ning Cui, Xue Wu, Yuhong Ye, Guo‐Yang Xu, Qing‐Shi Zhang, Lei Wang, Ying Hu, Hao Wang, Da Long

{"title":"Bispecific Peptide Binds to VEGFR2 and Integrin αvβ3, Forming an Artificial Extracellular Matrix for Anti‐Ocular Neoangiogenesis","authors":"Ye Zhang, Kuo Zhang, Ling Xu, Xinmin Lu, Ping Hu, Jinyi Long, Ning Cui, Xue Wu, Yuhong Ye, Guo‐Yang Xu, Qing‐Shi Zhang, Lei Wang, Ying Hu, Hao Wang, Da Long","doi":"10.1002/smll.202409664","DOIUrl":"https://doi.org/10.1002/smll.202409664","url":null,"abstract":"Ocular neovascularization (NV) leads to vision loss in various pathological conditions. Current therapies primarily inhibit vascular endothelial growth factor (VEGF) signaling; however, targeting additional pathways may improve outcomes. A bispecific peptide (BsPt) is developed that targets VEGFR2 and integrin αvβ3 to treat retinal neovascularization (RNV) and choroidal neovascularization (CNV) more effectively. BsPt binds to both receptors on endothelial cells (ECs) and forms nanofibrous networks on their surfaces, resulting in potent NV inhibition. In vitro, BsPt suppressed retinal EC migration and tube formation. Intravitreal BsPt injection outperformed aflibercept in mouse models of oxygen‐induced retinopathy (OIR) and laser‐induced CNV. RNA sequencing revealed that BsPt‐induced nanofibers upregulated extracellular matrix (ECM) and cell adhesion genes, which may contribute to anti‐angiogenesis and anti‐leakage effects. In summary, BsPt targeting VEGFR2 and integrin αvβ3 demonstrates enhanced therapeutic potential for RNV and CNV.","PeriodicalId":228,"journal":{"name":"Small","volume":"25 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

P‐Doped NiCo2S4/CoZn‐LDH Layered Heterostructures: Synergistically Improved Conductivity and Enhanced OH− Adsorption for High‐Performance Asymmetric Supercapacitors P掺杂NiCo2S4/CoZn - LDH层状异质结构：协同改善高性能非对称超级电容器的电导率和增强OH -吸附

IF 13.3 2区材料科学

Small Pub Date : 2025-07-31 DOI: 10.1002/smll.202504172

Ziyang Liu, Wenqiang Sun, Yingjie Li, Bona Zhang, Chenyong Wang, Xingjia Liu, Yulan Meng, Lizhao Liu, Xue‐Zhi Song, Xiaofeng Wang, Zhenquan Tan

{"title":"P‐Doped NiCo2S4/CoZn‐LDH Layered Heterostructures: Synergistically Improved Conductivity and Enhanced OH− Adsorption for High‐Performance Asymmetric Supercapacitors","authors":"Ziyang Liu, Wenqiang Sun, Yingjie Li, Bona Zhang, Chenyong Wang, Xingjia Liu, Yulan Meng, Lizhao Liu, Xue‐Zhi Song, Xiaofeng Wang, Zhenquan Tan","doi":"10.1002/smll.202504172","DOIUrl":"https://doi.org/10.1002/smll.202504172","url":null,"abstract":"Doping induces lattice distortion and modifies the electronic structure of materials, thereby enhancing their electrical conductivity and chemical stability. The built‐in electric field at heterojunction interfaces further promotes charge carrier migration and improves surface reaction kinetics. To leverage these synergistic effects, this study employs a combined approach involving sulfidation, phosphidation, and electrodeposition to achieve P‐doping and construct a heterojunction layered structure. Specifically, P‐doping is implemented through a phosphorization treatment of NiCo2S4 grown on nickel foam, followed by the electrodeposition of CoZn‐layered double hydroxide (LDH) onto the honeycomb‐like NiCo2S4 substrate. Density Functional Theory calculations demonstrate that this unique structural design markedly enhances the composite's electrical conductivity and optimizes the adsorption energy of OH− ions, leading to significantly improved ion/electron reaction kinetics. The resulting P‐NiCo2S4@CoZn‐LDH electrode exhibits a high areal capacitance of 15.00 F cm−2 at a current density of 5 mA cm−2. When assembled into an asymmetric supercapacitor (P‐NiCo2S4@CoZn‐LDH//activated carbon (AC)), the device achieves an energy density of 53.75 Wh kg−1 at a power density of 205.76 W kg−1, while maintaining 77.36% capacitance retention after 10 000 cycles. These findings highlight the synergistic benefits of doping and heterojunction engineering in enhancing charge transport and ion adsorption capabilities, offering a promising strategy for developing high‐performance supercapacitors.","PeriodicalId":228,"journal":{"name":"Small","volume":"5 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Stability Diversity in Elemental Phosphorus: The Case of Black, Violet, and Fibrous Red Phosphorus 元素磷的环境稳定性多样性：以黑色、紫色和纤维红磷为例

IF 13.3 2区材料科学

Small Pub Date : 2025-07-31 DOI: 10.1002/smll.202505083

Bowen Zhang, Zhaojian Sun, Wujia Chen, Qiang Li, Qingfeng Yan

{"title":"Environmental Stability Diversity in Elemental Phosphorus: The Case of Black, Violet, and Fibrous Red Phosphorus","authors":"Bowen Zhang, Zhaojian Sun, Wujia Chen, Qiang Li, Qingfeng Yan","doi":"10.1002/smll.202505083","DOIUrl":"https://doi.org/10.1002/smll.202505083","url":null,"abstract":"The rapid progress of elemental phosphorus families raises a pressing question: which of the allotropes is the most environmentally stable? Clear experimental evidence remains lacking. To this end, the stability discrepancies and underlying degradation chemistry of black phosphorus (BP), violet phosphorus (VP), and fibrous red phosphorus (FP), —the three most extensively studied among phosphorus families are systematically investigated, by monitoring the spectroscopic and microscopic evolution combined with first‐principles calculations. The ambient degradation behavior of three elemental phosphorus flakes follows pseudo‐first‐order reaction kinetics. The corresponding monoexponential fitting yields rate constants kBP, kVP, and kFP of 0.11, 0.18, and 0.23 day−1, respectively, quantitatively revealing that the environmental stability decreases in the order BP > VP > FP. Such stability discrepancy can also be qualitatively explained by the dissociative chemisorption energy of oxygen atoms based on first‐principles calculations. This work sheds new light on stability discrepancies and underlying degradation chemistry, paving the way for effective stabilization techniques.","PeriodicalId":228,"journal":{"name":"Small","volume":"19 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resolving Nanoslip, Solvation Inertia, and Charge Dynamics at Vibrating Solid-Liquid Interface. 固液界面的纳米滑移、溶剂化惯性和电荷动力学。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-31 DOI: 10.1002/smll.202505067

Nikhil Bhalla,Yeeun Song,Ju-Yeon Jo,Doojin Lee,Amir Farokh Payam

{"title":"Resolving Nanoslip, Solvation Inertia, and Charge Dynamics at Vibrating Solid-Liquid Interface.","authors":"Nikhil Bhalla,Yeeun Song,Ju-Yeon Jo,Doojin Lee,Amir Farokh Payam","doi":"10.1002/smll.202505067","DOIUrl":"https://doi.org/10.1002/smll.202505067","url":null,"abstract":"When a liquid contacts a charged solid surface, counterions in the liquid accumulate near the interface-a process traditionally described by models such as Helmholtz, Stern, and Debye-Hückel. However, these frameworks overlook the complex interplay between inertia and surface charge, and they simplify ions as mere point charges. This study employs vibrating solid surfaces to decouple and investigate the effects of inertia, ion-slipping, and electrostatic interactions at the molecular scale. This approach reveals \"inertial layer\" in the initial liquid strata, which plays a critical role in governing interface dynamics. Within this layer, a tunable Helmholtz zone is identified, where mechanical stiffness and electrostatic forces adjust in response to ion concentration. Beyond this lies a Debye screening region characterized by repulsive forces and electrostatic decoupling from the double-layer capacitor model. Using phosphate-buffered saline (PBS) as a model electrolyte, it is demonstrated that low ionic strength enhances interfacial stability, while high concentrations increase electrostatic repulsion, influencing nanoscale mechanical behavior. These insights refine the understanding of interfacial phenomena and hold significant implications for biosensing, catalysis, and energy storage technologies.","PeriodicalId":228,"journal":{"name":"Small","volume":"139 1","pages":"e2505067"},"PeriodicalIF":13.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144748142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theoretical Study on the Thermodynamics of Si(001) Surface. Si（001）表面热力学的理论研究。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-31 DOI: 10.1002/smll.202505284

Han Zhong,Zhongying Xue,Pai Li,Xin Wei

引用次数: 0

Visible Light-Driven Soft Actuator Exhibiting Multistage Shape Morphing. 展示多级形状变形的可见光驱动软驱动器。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-31 DOI: 10.1002/smll.202507247

Xinyu Chen,Zhaozhong Li,Xinrui Deng,Yihai Yang,Jiangmin Yang,Yuhan Zhang,Xinyue Song,Zhen Yang,Zihui Ye,Zichen Wang,Lanying Zhang,Huai Yang,Guo-Hua Hu,Ruochen Lan

{"title":"Visible Light-Driven Soft Actuator Exhibiting Multistage Shape Morphing.","authors":"Xinyu Chen,Zhaozhong Li,Xinrui Deng,Yihai Yang,Jiangmin Yang,Yuhan Zhang,Xinyue Song,Zhen Yang,Zihui Ye,Zichen Wang,Lanying Zhang,Huai Yang,Guo-Hua Hu,Ruochen Lan","doi":"10.1002/smll.202507247","DOIUrl":"https://doi.org/10.1002/smll.202507247","url":null,"abstract":"Traditional soft robots, while praised for their flexibility and biocompatibility, often face challenges with complex motion and adaptability. In this work, a visible light-driven liquid crystalline network (LCN) film with a multistage photo-responsive behavior is judiciously designed and prepared. By integrating donor-acceptor stenhouse adducts (DASAs) into LCN matrix, it is found that the DASA exhibits polymerization temperature-dependent isomerization, indicating an opportunity to fabricate complex photo-driven soft actuators and devices by simply adjusting the polymerization conditions. By carefully controlling the polymerization temperature of LC/DASA precursor, the photo-induced color change as well as the photothermal effect of LCN film can be finely controlled with spatial precision so that the prepared DASA-LCN film presents multistage color changes and shape morphing under a constant visible light field. Finally, a soft actuator with time-resolved light-responsive deformations is achieved. This advancement demonstrates a straightforward method to prepare self-adaptive light-driven LCN devices without tedious synthesis, paving the way for soft robots that are not only reconfigurable but also inherently adaptive.","PeriodicalId":228,"journal":{"name":"Small","volume":"5 1","pages":"e07247"},"PeriodicalIF":13.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung-Derived Small Extracellular Vesicles Containing miR-15a-5p/miR-96-5p Promote Myocardial Fibrosis in Hypertrophic Cardiomyopathy via Targeting SMAD7. 含有miR-15a-5p/miR-96-5p的肺源性细胞外小泡通过靶向SMAD7促进肥厚性心肌病的心肌纤维化。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-31 DOI: 10.1002/smll.202501610

Minwen Long,Jinpeng Sun,Dongli Zhou,Can Chen,Jiangcheng Shu,Xiaobo Mao,Kunwu Yu,Minglu Liang,Long Chen,Yumei Wang,Min Cheng

{"title":"Lung-Derived Small Extracellular Vesicles Containing miR-15a-5p/miR-96-5p Promote Myocardial Fibrosis in Hypertrophic Cardiomyopathy via Targeting SMAD7.","authors":"Minwen Long,Jinpeng Sun,Dongli Zhou,Can Chen,Jiangcheng Shu,Xiaobo Mao,Kunwu Yu,Minglu Liang,Long Chen,Yumei Wang,Min Cheng","doi":"10.1002/smll.202501610","DOIUrl":"https://doi.org/10.1002/smll.202501610","url":null,"abstract":"Small extracellular vesicles (sEVs) are membrane-bound nanoparticles released by cells for intercellular or inter-tissue communication and play key roles in multiple cardiovascular disorders. However, the mechanisms underlying sEV-mediated myocardial fibrosis in hypertrophic cardiomyopathy (HCM) are not well understood. In this study, it is discovered that the levels of miR-15a-5p and miR-96-5p in circulating sEVs (sEVmiR-15a-5p/96-5p) are elevated in HCM patients with myocardial fibrosis. These sEVs enhance fibroblast proliferation and differentiation in vitro. Similar findings are observed in isopropanol (ISO)-induced myocardial fibrosis mouse model, where sEVmiR-15a-5p/96-5p levels are elevated, predominantly originating from lung-derived sEVs. GW4869-mediated sEV suppression reduces pulmonary/cardiac sEVmiR-15a-5p/96-5p levels, suggesting therapeutic potential. Importantly, the systemic trafficking of lung-derived sEVs is also mapped to cardiac tissue in vivo using a lung-specific lineage-tracing strategy using SFTPC (surfactant protein C) promoter-driven AAV9-CD63-GFP vectors. Administering lung-derived sEVs from ISO-treated mice into the myocardium increases cardiac fibroblast proliferation and scar formation. Furthermore, it is identified that miR-15a-5p and miR-96-5p directly target Smad7, reducing its expression, while SMAD7 overexpression reverses profibrotic effects. These findings indicate that lung-derived sEVmiR-15a-5p/96-5p may exacerbate myocardial fibrosis by targeting Smad7 in cardiac fibroblasts. Thus, lung-derived sEV miR-15a-5p and miR-96-5p can serve as novel biomarkers and therapeutic targets for managing HCM-related myocardial fibrosis.","PeriodicalId":228,"journal":{"name":"Small","volume":"4 1","pages":"e01610"},"PeriodicalIF":13.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Versatile Solvent‐Free Synthesis of Composite Polymer Electrolytes for Thin High‐Performance Solid‐State Lithium Metal Batteries 薄型高性能固态锂金属电池的多功能无溶剂合成复合聚合物电解质

IF 13.3 2区材料科学

Small Pub Date : 2025-07-31 DOI: 10.1002/smll.202504166

Daniel Döpping, Annika Buchheit, Xiaochen Liu, Anika Goecke, Alexander P. Grimm, Dominik Voll, Manfred Wilhelm, Martin Finsterbusch, Martin Winter, Gunther Brunklaus, Patrick Théato

{"title":"Versatile Solvent‐Free Synthesis of Composite Polymer Electrolytes for Thin High‐Performance Solid‐State Lithium Metal Batteries","authors":"Daniel Döpping, Annika Buchheit, Xiaochen Liu, Anika Goecke, Alexander P. Grimm, Dominik Voll, Manfred Wilhelm, Martin Finsterbusch, Martin Winter, Gunther Brunklaus, Patrick Théato","doi":"10.1002/smll.202504166","DOIUrl":"https://doi.org/10.1002/smll.202504166","url":null,"abstract":"The development of high‐performance solid‐state lithium metal batteries (SSBs) relies on the invention of efficient composite polymer electrolytes (CPEs) that offer both high ionic conductivity and mechanical stability. However, mixing polymers and inorganic particles often leads to inhomogeneous distributions, inhibiting ion movement. This work introduces a novel solvent‐free synthesis for thin CPE films, enabling scalable and straightforward electrolyte fabrication. The proposed hybrid electrolyte system consists of a self‐crosslinking polyether matrix incorporating lithium‐ion‐conducting ceramic particles. The synthesis method facilitates homogeneous dispersion of Li6.45Al0.05La3Zr1.6Ta0.4O12 (LLZO), thus preventing agglomeration and affording consistent electrochemical performance with film thicknesses of ≈30 µm. The ability to mix polymers and incorporate additives further boosts the electrolyte's tunability, providing a versatile approach. Electrochemical characterization reveals that the fabricated hybrid CPEs exhibit superior ionic conductivity (0.27 mS cm−1 at 60 °C) and compatibility with lithium metal, while their implementation in high‐mass‐loading lithium iron phosphate (LFP, 7 mg cm2) cathodes demonstrates exceptional cycling performance of over 200 cycles at 80% state of health (SOH) at 0.25 C. The CPEs are characterized by small amplitude oscillatory shear (SAOS) in the linear regime, Young module, tensile strength, scanning electron microscopy (SEM), energy‐dispersive X‐ray spectroscopy (EDX), and electrochemically in Li||Li and NMC622 (LiNi0.6Mn0.2Co0.2O2) /LFP||Li cells.","PeriodicalId":228,"journal":{"name":"Small","volume":"28 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Printing Techniques of MXene-Based Materials for Flexible Supercapacitors. 柔性超级电容器用mxene基材料的打印技术。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-31 DOI: 10.1002/smll.202505471

Mengping Dong,Wei Wei,Ze Nan,Ruimei Yuan,Miao Zhang,Zhenhua Lin,Chunhui Shou,Jingjing Chang

{"title":"Printing Techniques of MXene-Based Materials for Flexible Supercapacitors.","authors":"Mengping Dong,Wei Wei,Ze Nan,Ruimei Yuan,Miao Zhang,Zhenhua Lin,Chunhui Shou,Jingjing Chang","doi":"10.1002/smll.202505471","DOIUrl":"https://doi.org/10.1002/smll.202505471","url":null,"abstract":"MXene-based supercapacitors are becoming more flexible, portable, and highly integrated. Their exceptional quick charge/discharge, power density, and cycle life are drawing interest in energy storage devices. The paradigm shift in combination with printing technology offers a range of simple, low-cost, time-saving and environmentally friendly manufacturing techniques for supercapacitors, thus unlocking even greater potential for supercapacitors in future electronics. This review first summarized the synthesis of MXene materials, and the electrode structure of printed supercapacitors are introduced and discussed; after that, the printing technology of MXene-based supercapacitor electrodes and their multifunctional applications which beyond supercapacitors are also outlined; Lastly, the main obstacles and potential applications of MXene-based printed supercapacitors is outlined. In this review, current developments in MXene electrode materials for printed supercapacitors are examined. The aim is to provide more application prospects for the miniaturization of MXene-based printed supercapacitors. In addition, the versatility and wide range of applications of MXene are explored.","PeriodicalId":228,"journal":{"name":"Small","volume":"15 1","pages":"e05471"},"PeriodicalIF":13.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational Design of Copper‐Based Metallic Nano‐Antibiotic against Drug‐Resistant Bacteria Infection 抗耐药细菌感染铜基金属纳米抗生素的合理设计

IF 13.3 2区材料科学

Small Pub Date : 2025-07-31 DOI: 10.1002/smll.202407067

Along Han, Pengjun Han, Bolong Xu, Yahao Li, Qingyuan Wu, Shanshan Li, Yun Sun, Yigang Tong, Huiyu Liu, Huahao Fan

{"title":"Rational Design of Copper‐Based Metallic Nano‐Antibiotic against Drug‐Resistant Bacteria Infection","authors":"Along Han, Pengjun Han, Bolong Xu, Yahao Li, Qingyuan Wu, Shanshan Li, Yun Sun, Yigang Tong, Huiyu Liu, Huahao Fan","doi":"10.1002/smll.202407067","DOIUrl":"https://doi.org/10.1002/smll.202407067","url":null,"abstract":"The rapidly increasing global incidence of antibiotic‐resistant bacterial infections poses a serious threat to public health worldwide, demanding immediate development of novel antimicrobial approaches. In this study, a rationally designed multifunctional metallic nano‐antibiotic (MNAB) system using an in‐situ reduction method is developed. The strategic incorporation of cuprous species substantially enhanced antimicrobial activity against clinically isolated strains, including two Gram‐positive and four Gram‐negative bacterial species. Remarkably, the system exhibited minimum inhibitory concentrations (MIC) of ≈20 ppm for Gram‐positive bacteria and ≈60 ppm for Gram‐negative bacteria, demonstrating efficacy on par with conventional antibiotics. Mechanistic investigations revealed that MNABs exert their antimicrobial effects through potent oxidative damage to cellular membranes while simultaneously modulating multiple gene clusters, confirming their broad‐spectrum antimicrobial capabilities. This study provides a strategic blueprint for developing next‐generation antibiotic alternatives, offering a promising solution for combating drug‐resistant bacterial infections.","PeriodicalId":228,"journal":{"name":"Small","volume":"14 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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