IF 13.3 2区材料科学

Small Pub Date : 2025-07-02 DOI: 10.1002/smll.202503925

Yibin Zhang,Lixin Liu,Cha Huang,Neng Ling,Haoyang Wang,Ying Wang,Hanyu Jiang,Qian Liu,Miao Chen

{"title":"AuAgPt Trimetallic Alloy Nanoframes as Metabolic Regulators for Highly Efficient Low-Temperature Photothermal Therapy.","authors":"Yibin Zhang,Lixin Liu,Cha Huang,Neng Ling,Haoyang Wang,Ying Wang,Hanyu Jiang,Qian Liu,Miao Chen","doi":"10.1002/smll.202503925","DOIUrl":"https://doi.org/10.1002/smll.202503925","url":null,"abstract":"Low-temperature photothermal therapy (PTT) offers a promising alternative to traditional high-temperature PTT by minimizing damage to healthy tissues at mild temperatures (<45 °C), yet its efficacy is significantly challenged by the upregulation of heat shock proteins (HSPs) and low tumor ablation efficiency. Here AuAgPt trimetallic alloy nanoframes (AuAgPt NFs) are introduced as metabolic regulators, which can enter tumor cells to generate stable low-temperature photothermal effect (ca. 42 °C) under near-infrared irradiation, possess high catalytic activity to consume H2O2 and concentrate reactive oxygen species (ROS), and efficiently adsorb and remove glutathione (GSH). Furthermore, the intracellular local heating can perturb the levels of 14 metabolites including amino acids, adenine, uric acid and pyridoxine, leading to oxidative stress. All of these alterations caused by AuAgPt NFs can downregulate GPX4 and HSPs, and increase the Bax/Bcl-2 ratio, ultimately inducing ferroptosis and apoptosis to kill tumor cells. In vivo experiments demonstrate effective tumor ablation while maintaining high biosafety profiles. AuAgPt NFs featuring catalytic, adsorptive, and photothermal properties are constructed to synergistically regulate intracellular metabolites for inducing programmed cell death, providing a highly promising low-temperature PTT strategy.","PeriodicalId":228,"journal":{"name":"Small","volume":"36 1","pages":"e2503925"},"PeriodicalIF":13.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid and Sensitive Detection of miRNA by Single-Molecule Fluorescence Dequenching Assay with Target Recycled CRISPR/Cas12a Amplification System. 靶向循环CRISPR/Cas12a扩增系统单分子荧光脱猝法快速灵敏检测miRNA

IF 13.3 2区材料科学

Small Pub Date : 2025-07-02 DOI: 10.1002/smll.202412228

Tengfang Zhang,Leyan Cai,Zibin Chu,Ao She,Jiayu Yang,Xin Su

{"title":"Rapid and Sensitive Detection of miRNA by Single-Molecule Fluorescence Dequenching Assay with Target Recycled CRISPR/Cas12a Amplification System.","authors":"Tengfang Zhang,Leyan Cai,Zibin Chu,Ao She,Jiayu Yang,Xin Su","doi":"10.1002/smll.202412228","DOIUrl":"https://doi.org/10.1002/smll.202412228","url":null,"abstract":"Dysregulated miRNAs play a critical role in the development of cancers. A rapid and sensitive single-molecule fluorescence dequenching assay combined with a CRISPR/Cas12a-based target recycling amplification system for miRNA detection is developed. This single-molecule assay detects miRNAs down to ≈10 fM within 10 min. An automated single-molecule fluorescent puncta analysis procedure is also created, improving the signal-to-noise ratio by 3.76-fold compared to traditional hidden Markov model (HMM)based methods. The clinical applicability of this technique is demonstrated. Two key miRNA targets associated with non-small cell lung cancer (NSCLC) and ovarian cancer (OC) from 2867 datasets of the TCGA database are screened. Validation is initially conducted at the cell line level, followed by testing with tissue and blood samples from 10 patients with NSCLC and OC. The assay demonstrated high diagnostic accuracy, with receiver operating characteristic curves (area under the curve (AUC) > 0.93) and significant statistical differentiation (p < 0.001) between cancer and healthy samples. This method's exceptional sensitivity and speed highlight its potential for early cancer diagnostics and personalized medicine.","PeriodicalId":228,"journal":{"name":"Small","volume":"648 1","pages":"e2412228"},"PeriodicalIF":13.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Zn-Iodine" Co-Regulation Induced by Trifunctional Zn2+-Exchanged Electrolyte Additives for High-Areal-Capacity and Robust Zn-I2 Batteries. 三功能Zn2+交换电解质添加剂对高面积容量坚固型Zn-I2电池的“zn -碘”共调节作用

IF 13.3 2区材料科学

Small Pub Date : 2025-07-02 DOI: 10.1002/smll.202507166

Tonghui Shen,Xinyu Li,Huayu Wang,Anbin Zhou,Mengyao Liu,Meng Xu,Bingjie Tao,Weiliang Tian,Yi Zhao

{"title":"\"Zn-Iodine\" Co-Regulation Induced by Trifunctional Zn2+-Exchanged Electrolyte Additives for High-Areal-Capacity and Robust Zn-I2 Batteries.","authors":"Tonghui Shen,Xinyu Li,Huayu Wang,Anbin Zhou,Mengyao Liu,Meng Xu,Bingjie Tao,Weiliang Tian,Yi Zhao","doi":"10.1002/smll.202507166","DOIUrl":"https://doi.org/10.1002/smll.202507166","url":null,"abstract":"Aqueous Zn-I2 batteries featuring high safety and low cost attract considerable attention for grid-scale energy storage. However, the challenges of Zn dendrite growth, hydrogen evolution reaction, and polyiodide shuttling severely impede their practical application. This study introduces Zn2+-exchanged vermiculite nanosheets (ZVN) as a multifunctional electrolyte additive to optimize Zn2+ solvation structure, facilitating hydrated Zn ion de-solvation via the strong electron affinity of ZVN. Moreover, the in situ formed protective ZVN layer on Zn anode maintains superior ionic conductivity for Zn2+ transportation, enabling highly stable and dendrite-free Zn deposition. This dual mechanism enables a dendrite-free Zn anode with 99.82% Coulombic efficiency over 1 700 cycles in Zn//Cu cells. Simultaneously, the excellent iodine species trapping ability of ZVN effectively inhibits the polyiodide shuttling for improved iodine conversion efficiency. Therefore, the assembled Zn-I2 battery based on polyaniline/I- cathode exhibits a high areal capacity of 1.05 mAh cm-2 and ultra-long lifespan over 18 000 cycles. This study provides an efficient electrolyte additive with a \"Zn-iodine\" synergistic effect for advanced Zn-I2 batteries.","PeriodicalId":228,"journal":{"name":"Small","volume":"70 1","pages":"e2507166"},"PeriodicalIF":13.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Ho3+‐Yb3+ and Nd3+‐Yb3+‐Ho3+ Doped LiLuF4 Nanothermometers for NIR‐II Imaging: Elucidation of the LiLuF4 Structure via 3D Electron Diffraction 探索Ho3+‐Yb3+和Nd3+‐Yb3+‐Ho3+掺杂LiLuF4纳米温度计的近红外成像：通过3D电子衍射阐明LiLuF4的结构

IF 13.3 2区材料科学

Small Pub Date : 2025-07-02 DOI: 10.1002/smll.202502818

Anna M. Kaczmarek, Mirijam Lederer, Laurens Bourda, Zofia Petryna, Simona Premcheska, Christian R. Göb, Andre G. Skirtach, Kristof Van Hecke

{"title":"Exploring Ho3+‐Yb3+ and Nd3+‐Yb3+‐Ho3+ Doped LiLuF4 Nanothermometers for NIR‐II Imaging: Elucidation of the LiLuF4 Structure via 3D Electron Diffraction","authors":"Anna M. Kaczmarek, Mirijam Lederer, Laurens Bourda, Zofia Petryna, Simona Premcheska, Christian R. Göb, Andre G. Skirtach, Kristof Van Hecke","doi":"10.1002/smll.202502818","DOIUrl":"https://doi.org/10.1002/smll.202502818","url":null,"abstract":"Temperature measurements in biological systems deliver important information about the occurrence and location of diseases such as cancer. Also, certain therapies rely on local heating of tumor tissue, and therefore, feedback on the heating of nearby healthy tissue is valuable. However, classical thermometers are not suitable for precise temperature detection in living systems. Because of this, alternative ways to measure temperature, such as luminescence‐based thermometry, have been gaining interest and relevance for medical diagnostics and treatment support. In this work, LiLuF4‐based nanocrystals are employed to develop novel ratiometric thermometers based on the rarely explored Ho3+‐Yb3+ and Nd3+‐Yb3+‐Ho3+ systems. After coating with a phospholipid bilayer, these thermometers show very good stability and thermometric performance in water and in skin‐mimicking tissue phantoms. The proposed Ho‐Yb‐Nd thermometry system allows constructing three separate thermometers within one material under one excitation wavelength. As there has been no scheelite single‐crystal structure of LiLuF4 reported to date, its single‐crystal structure is determined with the use of three‐dimensional Electron Diffraction analysis (3D ED) employing highly crystalline nanoparticles (<50 nm), which emphasizes the exciting potential of 3D ED for determining the crystal structure of inorganic nanoparticles.","PeriodicalId":228,"journal":{"name":"Small","volume":"92 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MOF-74 Nanofibers as an Advanced Porous Material for Air-Bearing Technology. MOF-74纳米纤维在空气轴承技术中的应用

IF 13.3 2区材料科学

Small Pub Date : 2025-07-02 DOI: 10.1002/smll.202411108

Jacopo Andreo,Xiangjiang Yu,Ekaterina Chernova,Stefan Wuttke

引用次数: 0

Rational Engineering on Copper-Silver-Ruthenium Heterostructures for the Electrocatalytic Conversion of Nitrate and Glycerol. 硝酸和甘油电催化转化用铜-银-钌异质结构的合理工程。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202505948

Qi Wang,Yi Shen

{"title":"Rational Engineering on Copper-Silver-Ruthenium Heterostructures for the Electrocatalytic Conversion of Nitrate and Glycerol.","authors":"Qi Wang,Yi Shen","doi":"10.1002/smll.202505948","DOIUrl":"https://doi.org/10.1002/smll.202505948","url":null,"abstract":"N Coupling nitrate reduction reaction (NO3RR) with glycerol oxidation reaction (GOR) establishes a sustainable \"C─N co-conversion\" electrolysis system to generate ammonium formate. Unfortunately, the rational design of high-performance bifunctional electrocatalysts remains challenging. Herein, we developed a 3D Ag/Ru-decorated CuO/Cu(OH)2 heterostructures supported by copper foams via interface engineering. The optimal catalyst exhibited outstanding NO3RR and GOR performance, achieving Faradaic efficiency (FE) of 97.3% and yield of 9.85 mg h-1 cm-2 at -0.5 V vs. RHE for NH3 synthesis, and FE of 82.6% and yield of 90.31 mg h-1 cm-2 at 1.55 V vs. RHE for formate production. Mechanistic studies revealed that the decoration of Ag and Ru atoms led to electron redistribution around the copper sites, promoting proton-coupled electron transfer and optimizing the adsorption of the reactants/intermediates. Notably, on the basis of the as-prepared bifunctional electrode, a \"NO3RR || GOR\" electrolyzer was constructed, which achieved simultaneous output of NH3 and formate with a current density of 100 mA cm-2 at only 1.48 V. The performance of the electrolyzer was further demonstrated using simulated nitrate pollutants and crude glycerol as feedstock, yielding 20.9 g of ammonium formate via a 4-h electrolysis. This work demonstrates a sustainable pathway for the synthesis of high-value-added ammonium formate by constructing an efficient bifunctional electrocatalyst through rational interfacial engineering.","PeriodicalId":228,"journal":{"name":"Small","volume":"26 1","pages":"e2505948"},"PeriodicalIF":13.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Memristive Fibers for Intelligent Textiles Information Storage and Processing in Multi-Scenarios. 多场景智能纺织品信息存储与处理的记忆纤维。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202505191

Shenglong Huang,Zizhao Ding,YiLun Cheng,Zixiang Zhao,Dou Zhang,Chao Jiang

{"title":"Memristive Fibers for Intelligent Textiles Information Storage and Processing in Multi-Scenarios.","authors":"Shenglong Huang,Zizhao Ding,YiLun Cheng,Zixiang Zhao,Dou Zhang,Chao Jiang","doi":"10.1002/smll.202505191","DOIUrl":"https://doi.org/10.1002/smll.202505191","url":null,"abstract":"Memristive fibers combine information storage and computing in textile-compatible crossbar arrays, enabling intelligent textiles to process signals from integrated electronics. A simple, cost-effective coating method for complex fiber surfaces with insufficient conductivity or difficult to withstand high pressure plays a key role in textile memristor tech. Here, a high-performance and reliable textile memristor fabricated from robust copper-tin oxide coated carbon fibers (CuSnO@Cf) memristive fibers through a process involving two-stage selective electroless plating and subsequent thermal oxidation is reported. The surface coating of the memristive fiber includes a self-lopaded active electrode containing metal/intermetallic compounds (metal/IMCs), and a memristive functional layer (bimetallic amorphous oxide), which makes it exhibit a low set voltage (≈0.342 V), long retention time (>104 s) for multilevel storage (5 stages), high ON/OFF ratio (up to 6.58 × 105), low energy consumption (34.5 pW), multi conductivity state (24), excellent synaptic plasticity, outstanding stability and durability. Besides, the textile memristor exhibits good repeatability and multi-level storage capability between devices, and can clearly recognize letters (H, V, O) through offline training and weight mapping. Highly compatible with intelligent textiles, the technology enables real-time diagnostics with accurate physiological data analysis. These advanced information processing capabilities will significantly advance intelligent textiles systems.","PeriodicalId":228,"journal":{"name":"Small","volume":"17 26 1","pages":"e2505191"},"PeriodicalIF":13.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlorophobic Iron Hydrogen Phosphite as OER‐Active Electrocatalyst in Anion Exchange Membrane (Sea)Water Electrolysis 疏氯亚磷酸氢铁作为OER活性电催化剂在阴离子交换膜（海）水电解中的应用

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202505781

Chandni Das, Nibedita Sinha, Aathira Nair, Santanu Pal, Kavita Joshi, Poulomi Roy

{"title":"Chlorophobic Iron Hydrogen Phosphite as OER‐Active Electrocatalyst in Anion Exchange Membrane (Sea)Water Electrolysis","authors":"Chandni Das, Nibedita Sinha, Aathira Nair, Santanu Pal, Kavita Joshi, Poulomi Roy","doi":"10.1002/smll.202505781","DOIUrl":"https://doi.org/10.1002/smll.202505781","url":null,"abstract":"Seawater electrolysis is recognized as a promising technology to cater to the worldwide drive for sustainable hydrogen production; however, its practical viability is often hindered by the inevitable anode corrosion arising from the electrode side reactions owing to the presence of high chloride content which eventually degrade the electrode performance eventually. Herein, the design of unprecedented ammonium iron hydrogen phosphite (FeHPhi) along with a trace amount of Cu, is reported as the unique and much desired electrode material for seawater electrolysis due to its special chloride repellant nature along with great electrocatalytic activity toward water oxidation. The [HPO3]2− oxoanion as Lewis base in the structure effectively restricts chloride ions, while the Fe center acts as Lewis acid offering an active site for water oxidation, also well‐supported theoretically. Leveraging this frustrated Lewis pair combination, the electrocatalyst achieves a high current density of 500 mA cm−2 at 344 mV overpotential in alkaline real seawater with impressive robustness to sustain for 200 h when operated under chlorine evolution reaction dominating region (>2 V). The electrocatalyst also demonstrates superior performance in anion exchange membrane freshwater and seawater electrolysis, demonstrating its potential applicability.","PeriodicalId":228,"journal":{"name":"Small","volume":"15 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Superhydrophilic and Fouling-Free COF Armor for Ultrafast Oil-Water Separation. 用于超快油水分离的工程超亲水无垢COF护甲。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202505330

Mi Zhou,Jingwen Zhou,Linlin Yan,Suyang Li,Xinwen Cao,Yingjie Zhang,Jun Ma,Lu Shao,Zongli Xie,Xiquan Cheng

引用次数: 0

Mutable Polarization Switching Characteristics in Wurtzite Al1- xScxN Ferroelectric Films Enabled by Sc-Doping. sc掺杂使纤锌矿Al1- xScxN铁电薄膜的可变极化开关特性。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202502865

Youdi Gu,Shu Shi,Hanxin Su,Geng Huangfu,Lanxin Jia,Siqin Li,Kaixuan Sun,Yichen Wu,Tao Zeng,Siewlang Teo,Ming Lin,Yao Zhu,Han Wang,Jingsheng Chen

{"title":"Mutable Polarization Switching Characteristics in Wurtzite Al1- xScxN Ferroelectric Films Enabled by Sc-Doping.","authors":"Youdi Gu,Shu Shi,Hanxin Su,Geng Huangfu,Lanxin Jia,Siqin Li,Kaixuan Sun,Yichen Wu,Tao Zeng,Siewlang Teo,Ming Lin,Yao Zhu,Han Wang,Jingsheng Chen","doi":"10.1002/smll.202502865","DOIUrl":"https://doi.org/10.1002/smll.202502865","url":null,"abstract":"Wurtzite ferroelectric aluminum scandium nitrides (Al1- xScxN) are highly appealing for their large remanent polarization, steep hysteresis, and easy integration with multiple mainstream semiconductor platforms. However, their applications are constrained by the inherently high coercive field (Ec), desperately needing comprehensive research of polarization switching for potentially lowering Ec. In particular, the correlations between polarization switching mechanisms and Sc doping levels remain underexplored. Here, the polarization switching kinetics in wurtzite ferroelectric Al1- xScxN (x = 0.25-0.3) subjected to varied voltage amplitudes and pulse durations are investigated, revealing a mutable polarization switching. The Al0.75Sc0.25N sample displays uniform switching behavior described by the Kolmogorov-Avrami-Ishibashi (KAI) model, while the intermediate composition Al0.725Sc0.275N exhibits an ambiguous switching mechanism, more aligned with KAI model-based on mathematical fitting validation. Especially, Al0.7Sc0.3N with obviously reduced coercive and activation fields, exhibits a nucleation-limited-switching (NLS) mechanism. It is found that higher-level Sc doping generates more nucleation sites, reducing energy barriers and accelerating nucleation switching, driving the transition from KAI to NLS. Energetic analysis further elucidates the doping-induced crossover of switching mechanisms. These results provide new insight into the fundamental understanding of polarization switching in wurtzite ferroelectric nitrides, which is critical for realizing their optimal and reliable applications.","PeriodicalId":228,"journal":{"name":"Small","volume":"26 1","pages":"e2502865"},"PeriodicalIF":13.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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