Ji Myeon Park, Hyojun Lim, Ju Young Kim, Weiyin Chen, Jin Hyeong Lee, Seul Jeong, Hwa Young Choi, Jaekyung Sung, Yun Chan Kang, Ju Li, Jin‐Sung Park
{"title":"NaCl‐Templated Iron Sulfide/N‐Doped Carbon Microspheres for High‐Performance Sodium‐Ion Batteries: From Nanostructural Design to Pouch Cells","authors":"Ji Myeon Park, Hyojun Lim, Ju Young Kim, Weiyin Chen, Jin Hyeong Lee, Seul Jeong, Hwa Young Choi, Jaekyung Sung, Yun Chan Kang, Ju Li, Jin‐Sung Park","doi":"10.1002/smll.76162","DOIUrl":"https://doi.org/10.1002/smll.76162","url":null,"abstract":"In this study, we report the rational design of NaCl‐templated iron sulfide/N‐doped carbon (FeS‐NaCl@NC) microspheres as high‐performance anodes for sodium‐ion batteries. A scalable spray pyrolysis process combined with subsequent sulfidation and polydopamine‐derived carbon coating enables the formation of three‐dimensional (3D) interconnected porous architectures with conformal N‐doped carbon layers. The NaCl template plays a critical role in generating internal void networks and mesoporous structures, facilitating electrolyte penetration and shortening Na <jats:sup>+</jats:sup> diffusion pathways, while the N‐doped carbon coating enhances electronic conductivity and interfacial stability. As a result, FeS‐NaCl@NC microspheres exhibit outstanding electrochemical performance, maintaining a high discharge capacity of 576.3 mA h g <jats:sup>−1</jats:sup> after 100 cycles at 1.0 A g <jats:sup>−1</jats:sup> and delivering remarkable rate capability (251.7 mA h g <jats:sup>−1</jats:sup> at 10.0 A g <jats:sup>−1</jats:sup> ). Notably, the improved cycling stability is rationalized by nano‐indentation results, indicating enhanced mechanical resilience against repeated volume changes. In addition, the origin of the superior rate capability is comprehensively elucidated through combined electrochemical and kinetic analyses, confirming that the designed structure enables accelerated Na <jats:sup>+</jats:sup> transport and charge transfer. Moreover, the practical feasibility of FeS‐NaCl@NC microspheres is validated through pouch‐type full‐cell evaluation, demonstrating its strong potential for sodium‐ion storage applications.","PeriodicalId":228,"journal":{"name":"Small","volume":"16 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mingyu Liu, Na Lv, Dongrui Li, Shengjun Sun, Yujie Feng, Mohamed S. Hamdy, Zhengwei Cai, Changliang Liu, Xuping Sun, Bo Tang
{"title":"Efficient and Long‐Lasting Seawater Oxidation Over a Sodium Nitroprusside‑Modified NiFe Layered Double Hydroxide","authors":"Mingyu Liu, Na Lv, Dongrui Li, Shengjun Sun, Yujie Feng, Mohamed S. Hamdy, Zhengwei Cai, Changliang Liu, Xuping Sun, Bo Tang","doi":"10.1002/smll.76149","DOIUrl":"https://doi.org/10.1002/smll.76149","url":null,"abstract":"Despite the great potential of direct seawater electrolysis technology in alleviating freshwater scarcity for green hydrogen production, its practical application is severely limited by the degradation of anode catalysts under chloride‑rich conditions. In this study, we report a sodium nitroprusside‑modified NiFe layered double hydroxide on nickel foam (SNP@NiFe LDH/NF) as an anode for alkaline seawater oxidation electrocatalysis. Such SNP@NiFe LDH/NF delivers a current density ( <jats:italic>j</jats:italic> ) of 1000 mA cm <jats:sup>−2</jats:sup> at an overpotential of 380 mV. Meanwhile, it demonstrates excellent long‑term durability, sustaining operation for 1100 h at 1000 mA cm <jats:sup>−2</jats:sup> and 900 h at 2000 mA cm <jats:sup>−2</jats:sup> , with a total operating time of 2000 h. Furthermore, the anion‐exchange membrane electrolyzer constructed using SNP@NiFe LDH/NF and Pt/C/NF as the anode and cathode, respectively, delivers a <jats:italic>j</jats:italic> of 500 mA cm <jats:sup>−2</jats:sup> at a cell voltage of 2.30 V, while running stably for 600 h.","PeriodicalId":228,"journal":{"name":"Small","volume":"42 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SmallPub Date : 2026-10-18Epub Date: 2026-09-09DOI: 10.1002/smll.75641
Yi Zeng, Shun Lu, Yuan Wang, Saddick Donkor, Donna Cairns, Xingqun Zheng, Qingsong Hua, Ben Bin Xu
{"title":"Towards Sustainable Energy-Saving Hydrogen Production: Recent Advances in Tungsten-Based Urea Oxidation Electrocatalysts","authors":"Yi Zeng, Shun Lu, Yuan Wang, Saddick Donkor, Donna Cairns, Xingqun Zheng, Qingsong Hua, Ben Bin Xu","doi":"10.1002/smll.75641","DOIUrl":"10.1002/smll.75641","url":null,"abstract":"<p>The urea oxidation reaction (UOR), as a multi-electron coupling reaction, provides an efficient route for treating urea-containing wastewater and a sustainable strategy for energy-saving H2 production. Nickel-based catalysts attract attention due to their low cost and favorable activity, but single-metal catalysts still suffer from limited activity and stability. To overcome these limitations, researchers enhance performance through doping, structural regulation, and composite strategies. Tungsten (W), with high electronegativity, multivalence, excellent conductivity, and environmental friendliness, is widely incorporated into nickel-based catalysts to modulate electronic structure, improve adsorption and conversion of intermediates, and enhance stability. This review summarizes recent progress in W-based UOR catalysts, focusing on reaction mechanisms, structural regulation strategies, and performance improvement approaches. Current challenges include active site identification, catalyst stability, reaction selectivity, and the lack of standardized evaluation protocols. Future research directions involve elucidating catalytic mechanisms, optimizing material design, establishing unified evaluation standards, and developing high-performance W-based composites, aiming to advance UOR applications in energy conversion, wastewater treatment, and sensing.</p>","PeriodicalId":228,"journal":{"name":"Small","volume":"22 58","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.75641","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148915400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiaqian Li, Yimeng Li, Pengli Gao, Guanghui Li, Lishuang Guo, Yuan Feng, Jie Tian, Yu An
{"title":"Multifunctional Magneto‑Thermal Probe Enhances the Efficacy of Tumor Therapy as a Tumor Nanovaccine","authors":"Jiaqian Li, Yimeng Li, Pengli Gao, Guanghui Li, Lishuang Guo, Yuan Feng, Jie Tian, Yu An","doi":"10.1002/smll.76209","DOIUrl":"https://doi.org/10.1002/smll.76209","url":null,"abstract":"Magnetic hyperthermia therapy (MHT) is an emerging thermotherapeutic approach that has shown promising potential in cancer treatment. However, conventional MHT strategies exhibit limited capacity to activate anti‐tumor immune responses, an essential factor for preventing cancer recurrence and metastasis. Therefore, improving the immunomodulatory efficacy of MHT remains a critical challenge. This study designed and developed a novel magneto‐thermal probe, PSRNP, by conjugating anti‐PD‐L1 and RS09 peptides onto the surface of superparamagnetic iron oxide nanoparticles. The resulting PSRNP nanoprobes demonstrated excellent magneto‐thermal conversion efficiency and favorable biocompatibility. In vivo analysis demonstrated that PSRNP‐mediated MHT effectively remodels the tumor microenvironment. Meanwhile, PSRNP‐mediated MHT showed superior immune activation effects, with a 5.14‐fold increase in intratumoral CD86 <jats:sup>+</jats:sup> cells and a 3.30‐fold increase in CD137 <jats:sup>+</jats:sup> cells compared with the Fe <jats:sub>3</jats:sub> O <jats:sub>4</jats:sub> ‐mediated MHT group. Furthermore, PSRNP‐mediated MHT potentiated the therapeutic efficacy of tumor‐infiltrating lymphocyte therapy and prevented tumor recurrence after surgical resection. The PSRNP probe represents an innovative platform for improving the immunotherapeutic performance of MHT in solid tumors. The findings of this study establish a theoretical and experimental foundation for advancing MHT as a synergistic cancer treatment strategy.","PeriodicalId":228,"journal":{"name":"Small","volume":"193 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SmallPub Date : 2026-10-18DOI: 10.1002/smll.202511010
Nikhil Komalla, Nelson Y. Dzade
{"title":"Rational Design Strategies Toward Efficient and Stable Electrocatalysts for Hydrogen Production via Water Electrolysis: A Comprehensive Review","authors":"Nikhil Komalla, Nelson Y. Dzade","doi":"10.1002/smll.202511010","DOIUrl":"https://doi.org/10.1002/smll.202511010","url":null,"abstract":"Active and stable electrocatalysts are critical for sustainable hydrogen production, particularly for high‐current‐density water electrolysis and specialized applications like seawater splitting. However, most water‐splitting electrocatalysts show limited activity at high current densities and poor long‐term stability, making it difficult to meet the stringent performance and durability requirements of industrial‐scale applications (operation at high current density (≥500 mA/cm) and long‐term stability (>1,000 h). This review emphasizes the need to rationally design efficient, stable, earth‐abundant, non‐noble‐metal electrocatalysts for scalable, cost‐effective hydrogen production. We discuss progress in developing earth‐abundant transition‐metal oxides, oxyhydroxides, phosphides, nitrides, carbides, and dichalcogenides. We also present an in‐depth analysis of key strategies to enhance the electrocatalytic activity and stability of transition‐metal‐based materials, focusing on hydrogen evolution reactions via water electrolysis. Practical strategies—including heteroatom doping, heterostructure formation, defect engineering, and phase and strain engineering—are discussed within a synergistic experimental and theoretical framework, highlighting their ability to tune electronic structure, enhance surface properties, and improve overall catalytic efficiency. This unique approach is a key feature of this review and guides rational electrocatalyst design. Finally, we provide perspectives on the challenges and opportunities for advancing robust and highly active electrocatalysts for practical hydrogen production via water electrolysis.","PeriodicalId":228,"journal":{"name":"Small","volume":"33 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Engineering Carbon Support Packing Density to Enhance Mass Transport in Fuel Cell Cathodes","authors":"Chang‐Song Ma, Lei Tong, Tong Li, Lu‐Lu Tang, Jun‐Jie Li, Tian‐Wei Song, Cong Xu, Kun‐Ze Xue, Shuai Li, Le Zhang, Yan‐Wei Ding, Hai‐Wei Liang","doi":"10.1002/smll.76289","DOIUrl":"https://doi.org/10.1002/smll.76289","url":null,"abstract":"To enhance the power output of proton exchange membrane fuel cells, improving the mass transport of protons and oxygen within the cathode catalyst layer is essential. The ionomer loading in the cathode catalyst layer is a key parameter governing the trade‐off between proton transport and oxygen transport: while a high ionomer loading facilitates proton conduction, it inevitably impairs oxygen transport. Herein, we demonstrate that reducing ionomer loading can be achieved by increasing the cathode catalyst layer packing density, which is controlled by rationally reducing the cavity size of hollow mesoporous carbon sphere (HMCS) supports. In situ electrochemical diagnostics reveal that a small‐cavity HMCS‐supported Pt catalyst, forming a high‐packing‐density catalyst layer, establishes a continuous ionomer network at a relatively low ionomer‐to‐carbon weight ratio of 0.6. This structure yields a low oxygen transport resistance of 0.70 s cm <jats:sup>−1</jats:sup> while maintaining efficient proton conduction. With a low cathode Pt loading of 0.1 mg <jats:sub>Pt</jats:sub> cm <jats:sup>−2</jats:sup> , the membrane electrode assembly delivers a rated power density of 1.03 W cm <jats:sup>−2</jats:sup> at 0.67 V under heat‐rejection‐constrained conditions in H <jats:sub>2</jats:sub> ‐air fuel cells.","PeriodicalId":228,"journal":{"name":"Small","volume":"25 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reconfiguring Zn‐Mn Battery via Controlled Water Nanoconfinement Within Zn‐Absence Electrolyte","authors":"Weidong He, Huize Zhang, Yefei Chen, Zhiyuan Jiang, Xiaobin Liao, Kangning Zhao, Zedong Lin, Huaping Zhao, Yong Lei, Zizheng Ai, Yongzhong Wu, Xiaopeng Hao","doi":"10.1002/smll.76325","DOIUrl":"https://doi.org/10.1002/smll.76325","url":null,"abstract":"Zn‐Mn batteries are appealing candidates for next‐generation stationary storage applications. Mainstream electrolytes use Zn <jats:sup>2+</jats:sup> ions as major charge carrier while the operating mechanism of Mn‐based cathode has been argued to be mostly dominated by proton intercalation/de‐intercalation and MnO <jats:sub>2</jats:sub> /Mn <jats:sup>2+</jats:sup> dissolution/deposition, which means that the Zn <jats:sup>2+</jats:sup> ions may not be essential in electrolyte composition. Herein, we demonstrate a new Zn‐Mn battery chemistry with Zn‐absence electrolyte (NH <jats:sub>4</jats:sub> Ac hybrid electrolyte). The use of Zn‐absence electrolyte greatly changes the charge storage mechanism of both cathode and anode. On the anode side, hydrous organic electrolyte with nanoscale water domains within the ethylene glycol matrix expands the electrochemical working window and prevents water decomposition. The Zn plating/stripping is found to be highly reversible and corrosion‐free, despite low concentration, due to the gradient solid‐electrolyte interphase formation and interfacial alloying reaction. On the cathode side, Mn‐based materials undergo the fast Grotthuss intercalation of protons from the hydrolysis of NH <jats:sub>4</jats:sub> <jats:sup>+</jats:sup> ions, which benefits the fast charging function. The Zn‐Mn batteries with Zn <jats:sup>2+</jats:sup> absence electrolyte show excellent cycling performance for over 2200 cycles, even outperforming the traditional Zn‐Mn battery system. This work provides a new design roadmap for smarter design of aqueous battery.","PeriodicalId":228,"journal":{"name":"Small","volume":"412 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High‐Performance Nitrate Photoreduction to Ammonia on Organic Photovoltaic Heterojunction Nanoparticles","authors":"Shinuo Guo, Liping Zhao, Jiayuan Sun, Xingqi Bi, Tao Guo, Wenkai Zhao, Guancheng Wu, Tengshuo Hou, Yuying Zhang, Guankui Long, Yi Liu, Zhaoyang Yao, Yaxiao Guo","doi":"10.1002/smll.76303","DOIUrl":"https://doi.org/10.1002/smll.76303","url":null,"abstract":"Photocatalytic nitrate reduction to ammonia (NO <jats:sub>3</jats:sub> RR) could alleviate the energy/environmental burdens associated with Haber‐Bosch process, however, still suffers from insufficient visible‐light utilization and low ammonia production rate. Herein, we present the first case of photocatalytic NO <jats:sub>3</jats:sub> RR using a platinum‐loaded organic photovoltaic heterojunction nanoparticle (OPV‐NP) as photocatalysts. The donor/acceptor interpenetrating network inner OPV‐NPs overcomes the limitation of intrinsically short exciton diffusion length of organic photosensitizers. By delicately tuning the chemical/topological structure of near‐infrared acceptors, the intermolecular packing strength and crystalline ordering are improved greatly, thus driving the more efficient generation/transport of charge carriers and ammonia production. As a result, the optimized OPV‐NPs achieves a first‐class photocatalytic ammonia production rate of 6.79 mmol g <jats:sup>−1</jats:sup> h <jats:sup>−1</jats:sup> and excellent operational stability during 40 h continuous photocatalysis under AM 1.5G simulated sunlight. This work not only highlights the considerable potential of OPV‐NPs in photocatalytic NO <jats:sub>3</jats:sub> RR but also provides valuable insights for rational material design in such a promising photocatalytic system.","PeriodicalId":228,"journal":{"name":"Small","volume":"56 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guocheng Deng, Mohit Verma, Seungwoo Yoo, Sami Malola, Xiaolin Liu, Taeyoung Ki, Megalamane S. Bootharaju, Hannu Häkkinen, Taeghwan Hyeon
{"title":"Isomeric Au 7 Cu 8 Nanoclusters With Identical Building Blocks but Distinct Assembly Modes","authors":"Guocheng Deng, Mohit Verma, Seungwoo Yoo, Sami Malola, Xiaolin Liu, Taeyoung Ki, Megalamane S. Bootharaju, Hannu Häkkinen, Taeghwan Hyeon","doi":"10.1002/smll.76342","DOIUrl":"https://doi.org/10.1002/smll.76342","url":null,"abstract":"Isomeric metal nanoclusters composed of identical building blocks provide an ideal platform for probing structure–property relationships at the atomic level; however, their controlled synthesis remains highly challenging. Herein, we report the synthesis and structural characterization of two structurally isomeric AuCu nanoclusters, [Au <jats:sub>7</jats:sub> Cu <jats:sub>8</jats:sub> (L) <jats:sub>2</jats:sub> (TBA) <jats:sub>4</jats:sub> Cl <jats:sub>6</jats:sub> ]PF <jats:sub>6</jats:sub> (L = PNP or PMNP, where PNP is 2,6‐bis(diphenylphosphino)pyridine, PMNP is 2,6‐bis(diphenylphosphinomethyl)pyridine, and TBA is <jats:italic>tert</jats:italic> ‐butylacetylide), denoted as Au <jats:sub>7</jats:sub> Cu <jats:sub>8</jats:sub> ‐ 1 and Au <jats:sub>7</jats:sub> Cu <jats:sub>8</jats:sub> ‐ 2 , respectively. Single‐crystal X‐ray diffraction analysis reveals that both isomers feature an Au <jats:sub>7</jats:sub> Cu <jats:sub>6</jats:sub> core constructed from two pentagonal bipyramidal Au <jats:sub>4</jats:sub> Cu <jats:sub>3</jats:sub> building blocks fused through a common Au atom. The two isomers differ in the assembly mode of the Au <jats:sub>4</jats:sub> Cu <jats:sub>3</jats:sub> units: in Au <jats:sub>7</jats:sub> Cu <jats:sub>8</jats:sub> ‐ 1 , fusion occurs through a gold atom at a vertex of the equatorial pentagon, whereas in Au <jats:sub>7</jats:sub> Cu <jats:sub>8</jats:sub> ‐ 2 , it occurs through an apical gold atom. Notably, Au <jats:sub>7</jats:sub> Cu <jats:sub>8</jats:sub> ‐ 1 exhibits intense near‐infrared phosphorescence at 752 nm with a photoluminescence quantum yield of 26.2% in solution, whereas Au <jats:sub>7</jats:sub> Cu <jats:sub>8</jats:sub> ‐ 2 is non‐emissive. Theoretical calculations reveal distinct electronic structures and excited‐state relaxation pathways for the two isomers, providing microscopic insight into their different photoluminescence behaviors. These findings deepen our understanding of how structural isomerism influences the electronic structures and photophysical properties of metal nanoclusters.","PeriodicalId":228,"journal":{"name":"Small","volume":"43 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefania Forciniti, Valentina Onesto, Anna Chiara Siciliano, Helena Iuele, Stefano D'Ugo, Norma Depalma, Cinzia Fasano, Alessandro D'Amuri, Giuseppe Gigli, Marcello G. Spampinato, Loretta L. del Mercato
{"title":"Sensing-Integrated Patient-Derived Tumorspheres Predict Chemotherapeutic Efficacy via Local Extracellular pH Dynamics (Small 58/2026)","authors":"Stefania Forciniti, Valentina Onesto, Anna Chiara Siciliano, Helena Iuele, Stefano D'Ugo, Norma Depalma, Cinzia Fasano, Alessandro D'Amuri, Giuseppe Gigli, Marcello G. Spampinato, Loretta L. del Mercato","doi":"10.1002/smll.75528","DOIUrl":"10.1002/smll.75528","url":null,"abstract":"<p><b>Personalized Drug Screening</b></p><p>A sensing-integrated 3D tumorsphere platform lights up local extracellular pH dynamics in patient-derived pancreatic ductal adenocarcinoma models. Ratiometric optical pH sensors embedded in biocompatible microgels reveal cell-associated acidification non-invasively during therapy. Distinct acidification signatures uncover patient-specific drug sensitivities, highlighting the potential of spatial metabolic mapping for personalized drug screening and precision oncology. More in Research Article e75149, Marcello G. Spampinato, Loretta L. del Mercato, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":228,"journal":{"name":"Small","volume":"22 58","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.75528","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}