IF 13.3 2区材料科学

Small Pub Date : 2025-05-27 DOI: 10.1002/smll.202501175

Mohsen Mohammadi,Jin Shang,Yuyang Li,Aiman Rahmanudin,Darius Jakonis,Magnus Berggren,Lars Herlogsson,Klas Tybrandt

{"title":"Miniaturized Soft and Stretchable Multilayer Circuits through Laser-Defined High Aspect-Ratio Printing.","authors":"Mohsen Mohammadi,Jin Shang,Yuyang Li,Aiman Rahmanudin,Darius Jakonis,Magnus Berggren,Lars Herlogsson,Klas Tybrandt","doi":"10.1002/smll.202501175","DOIUrl":"https://doi.org/10.1002/smll.202501175","url":null,"abstract":"Stretchable electronics enable seamless integration of wearables with the human body, thereby creating new opportunities in biomedical applications. Miniaturized multilayer stretchable printed circuit boards are key for achieving high functional density circuits with minimal footprint. However, current microfabrication technologies struggle with simultaneously achieving tissue-like softness (<<1 MPa), high resolution and low sheet resistance. This study demonstrates a scalable printing method that enables ultra-soft (<0.4 MPa) stretchable conductors (>300% strain) with high-resolution (<2.5 µm width) and high aspect-ratio tracks (>1) connected by ultra-fine (20 µm) vertical-interconnect-access (VIA) for multi-layered configurations. The method is based on stencil printing into laser-defined bio-masks comprising the abundant biopolymer lignin, thereby achieving printing capabilities beyond conventional methods in a sustainable manner. Based on the unique capabilities, a miniaturized multilayer ultra-soft wireless near-field-communication temperature logger is developed. Laser-defined printing can pave the way for the next generation of ultra-soft miniaturized wearables.","PeriodicalId":228,"journal":{"name":"Small","volume":"49 1","pages":"e2501175"},"PeriodicalIF":13.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cavity-Like Silver Aggregates-Based Colloidal SERS Microfluidic Platform for Highly Reproducible Online Reaction Process Analysis. 基于腔型银聚集体的胶体SERS微流控平台，用于高重复性在线反应过程分析。

IF 13.3 2区材料科学

Small Pub Date : 2025-05-27 DOI: 10.1002/smll.202501338

Shuoyang Yan,Zhiyang Zhang,Jiadong Chen,Qiaoning Wang,Yanzhou Wu,Yifan Sui,Shiyu Wang,Quande Che,Na Zhou,Ling Chen,Lingxin Chen

{"title":"Cavity-Like Silver Aggregates-Based Colloidal SERS Microfluidic Platform for Highly Reproducible Online Reaction Process Analysis.","authors":"Shuoyang Yan,Zhiyang Zhang,Jiadong Chen,Qiaoning Wang,Yanzhou Wu,Yifan Sui,Shiyu Wang,Quande Che,Na Zhou,Ling Chen,Lingxin Chen","doi":"10.1002/smll.202501338","DOIUrl":"https://doi.org/10.1002/smll.202501338","url":null,"abstract":"Process analytical technology (PAT) is a key tool in the chemical and biological production industry. However, it is still desirable to develop online PAT enabling rapid and sensitive detection of various reaction intermediates, to meet the requirements of precise and green chemistry. Here these challenges are addressed by developing a cavity-like silver aggregate (Ag cavity)-based colloidal surface-enhanced Raman scattering (SERS) microfluidic platform, which exhibits a reproducible flow detection window, enabling sensitive online monitoring and identification of the organic reaction intermediates of the model flow photochemical reactions. The key element of the platform is the colloidal Ag cavity prepared through a template-mediated method. Finite difference time domain (FDTD) simulation and molecular adsorption measurements indicate the increased electromagnetic field and the high surface area contribute to the high SERS sensitivity of the cavity-like silver aggregates. Moreover, the Ag cavity shows a long-term flow detection window in the microfluidic channel with high reproducibility (RSD = 3.72%). This platform is successfully used to monitor and analyze the photodegradation intermediates of the model antibiotics, indicating the promising practical applications. This study contributes to the advancement of online chemistry studies and provides an effective tool for online reaction monitoring across diverse organic production fields.","PeriodicalId":228,"journal":{"name":"Small","volume":"3 1","pages":"e2501338"},"PeriodicalIF":13.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superwetting, Self-Sterilizing Cu/CuZn-ZnO Grating via Laser Engineering for Advanced Droplet Sensing. 基于激光工程的超湿自杀菌Cu/CuZn-ZnO光栅用于先进的液滴传感。

IF 13.3 2区材料科学

Small Pub Date : 2025-05-27 DOI: 10.1002/smll.202502976

Yexin Pan,Xupeng Lu,Ruohan Yu,Le Jing,Yang Xu,Wing Yan Poon,Haosong Zhong,Siyu Chen,Molong Duan,Yang Liu,Mitch Guijun Li

{"title":"Superwetting, Self-Sterilizing Cu/CuZn-ZnO Grating via Laser Engineering for Advanced Droplet Sensing.","authors":"Yexin Pan,Xupeng Lu,Ruohan Yu,Le Jing,Yang Xu,Wing Yan Poon,Haosong Zhong,Siyu Chen,Molong Duan,Yang Liu,Mitch Guijun Li","doi":"10.1002/smll.202502976","DOIUrl":"https://doi.org/10.1002/smll.202502976","url":null,"abstract":"Controlling metal properties is essential for achieving functional applications, as metals show extreme tunability on surface energies, structural surface areas, and sterilization ability. Existing materials for respiratory droplet detection, critical for controlling infectious disease spread, often lack combined extreme wettability and intrinsic antimicrobial activity. Inspired by the photonic crystals of peacock feathers, a highly sensitive and self-sterilizing optical grating sensor is developed based on a core-shell nanostructured copper/copper-zinc and zinc oxide (Cu/CuZn-ZnO) composite (interconnected Cu or CuZn nanoparticles encapsulated by ZnO). A two-step laser-induced process controls the composite's properties, creating hierarchical, core-shell nanostructures and simultaneously tailoring surface energy and morphology for superhydrophilicity. This laser-engineered superwetting surface, combining increased surface area and low surface energy, amplifies aqueous droplet footprint diameter over fivefold, enabling picoliter-range electrical detection. The amounts and distribution of droplets can be analyzed using point-to-point optical Fourier translation analysis and classical statistics. The laser-generated ZnO and residual copper species provide inherent antimicrobial properties, achieving effective self-disinfection. This integrated superhydrophilicity and self-disinfection platform offers significant potential for advanced respiratory droplet analysis and public health monitoring.","PeriodicalId":228,"journal":{"name":"Small","volume":"33 1","pages":"e2502976"},"PeriodicalIF":13.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Lithiophilic Freestanding Hosts with SiOx‐Embedded Hierarchical Porous N‐Doped Carbon Nanofibers for Dendrite‐Free Lithium Metal Batteries 用于无枝晶锂金属电池的含SiOx嵌入分层多孔N掺杂碳纳米纤维的3D亲锂独立式主体

IF 13.3 2区材料科学

Small Pub Date : 2025-05-27 DOI: 10.1002/smll.202504223

Yeon Woo Nahm, Jae Seob Lee, Jae Hun Choi, Jung Sang Cho, Yun Chan Kang

{"title":"3D Lithiophilic Freestanding Hosts with SiOx‐Embedded Hierarchical Porous N‐Doped Carbon Nanofibers for Dendrite‐Free Lithium Metal Batteries","authors":"Yeon Woo Nahm, Jae Seob Lee, Jae Hun Choi, Jung Sang Cho, Yun Chan Kang","doi":"10.1002/smll.202504223","DOIUrl":"https://doi.org/10.1002/smll.202504223","url":null,"abstract":"3D host materials are promising for Li‐metal anodes (LMAs) because of their adaptability to volume changes and large areas that prevent current localization, hindering dendritic Li formation. Herein, freestanding porous N‐doped carbon nanofibers (PCNFs) with uniformly distributed SiOx are synthesized by electrospinning and subsequent carbonization. In these composites, tunnel‐like, open channels are formed between the CNFs by removing polystyrene (PS) and the hollow N‐doped nanocages (HNC) generated from zeolitic imidazolate frameworks‐8 (ZIF‐8) during carbonization, providing sufficient space for Li deposition. Accompanying these structural advantages, the adequate electron conductivity and lithophilic properties derived from the conductive N‐doped CNFs and insulating SiOx confer optimized characteristics for uniform Li distribution. The coulombic efficiency exceeds 98% over 160 cycles in asymmetrical cells at a current density of 2.0 mA cm−2, with stable voltage hysteresis and an average overpotential of 25 mV for 1350 h in symmetrical tests. Full cells assembled with composite anodes predeposited with Li exhibited excellent capacity retention, delivering 141 mAh g−1 at 2.0 C with LiNi0.6Co0.2Mn0.2O2 (NCM622) cathodes. The results highlight that the optimized combination of conductive CNFs, HNCs, and insulating SiOx effectively enables uniform Li deposition, significantly enhancing cycling stability and Coulombic efficiency (CE) of LMAs.","PeriodicalId":228,"journal":{"name":"Small","volume":"35 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuning Bismuth Metal-Organic Framework Topology for Enhanced Photocatalytic NO Oxidation. 调整铋金属-有机框架拓扑用于增强光催化NO氧化。

IF 13.3 2区材料科学

Small Pub Date : 2025-05-27 DOI: 10.1002/smll.202502116

Chen Wu,Jincheng Mu,Xueying Wang,Pui-Yu Ho,Min Zhou,Can Yang,Chi-Fai Leung,Yu Huang,Wing-Kei Ho

{"title":"Tuning Bismuth Metal-Organic Framework Topology for Enhanced Photocatalytic NO Oxidation.","authors":"Chen Wu,Jincheng Mu,Xueying Wang,Pui-Yu Ho,Min Zhou,Can Yang,Chi-Fai Leung,Yu Huang,Wing-Kei Ho","doi":"10.1002/smll.202502116","DOIUrl":"https://doi.org/10.1002/smll.202502116","url":null,"abstract":"Precise topological-structural control over bismuth-based metal-organic frameworks (Bi-MOFs) is hampered by the challenge of balancing thermodynamics and kinetics. Such balance is achieved in three well-defined Bi-MOFs with crystalline, semi-crystalline, and amorphous topologies via a straightforward secondary building unit approach in bismuth-2-aminoterephthalic acid (Bi-BDC-NH2). The structure of Bi-BDC-NH2 is confirmed by single-crystal X-ray diffraction (XRD) to consist of BiO9 nodes. The amount of 2-aminoterephthalic acid is varied to modulate the topology via competitive complexation and thus control the thermodynamic and kinetic nucleation products. Through regulating the ligand-to-metal ratio of H2BDC-NH2 to Bi, an appropriate balance of the thermodynamic-versus-kinetic structural \"trade-off\" is achieved. The fine topologies of Bi-MOFs are determined by single-crystal XRD, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, and X-ray absorption fine structure. For the first time, it is reported that applying Bi-MOFs with varying topological structures as photocatalysts for removing nitric oxide (NO) demonstrates that the amorphisation improves the photogenerated charge separation efficiency and adsorption and activation of O2. This work offers a guide in complex topological-structural control, which is conducive for those to develop highly efficient MOFs-based photocatalysts.","PeriodicalId":228,"journal":{"name":"Small","volume":"34 1","pages":"e2502116"},"PeriodicalIF":13.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vessel-Like Microtunnels with Biomimetic Octopus Tentacles for Seizing and Detecting Exosomes to Diagnose Pancreatic Cancer. 具有仿生章鱼触手的血管样微隧道用于捕获和检测外泌体诊断胰腺癌。

IF 13.3 2区材料科学

Small Pub Date : 2025-05-27 DOI: 10.1002/smll.202502763

Li-Li Xu,Ming Wang,Yi-Ke Wang,Yi-Jing Chen,Yu-Xin Zhang,Yan-Qiu Zhang,Shi-Bo Cheng,Min Xie,Wei-Hua Huang

{"title":"Vessel-Like Microtunnels with Biomimetic Octopus Tentacles for Seizing and Detecting Exosomes to Diagnose Pancreatic Cancer.","authors":"Li-Li Xu,Ming Wang,Yi-Ke Wang,Yi-Jing Chen,Yu-Xin Zhang,Yan-Qiu Zhang,Shi-Bo Cheng,Min Xie,Wei-Hua Huang","doi":"10.1002/smll.202502763","DOIUrl":"https://doi.org/10.1002/smll.202502763","url":null,"abstract":"Microchip-based exosome analysis has emerged as a promising approach for liquid biopsy in cancer diagnosis, treatment monitoring, and prognostic evaluation. However, current microchips for exosome analysis typically rely on planar, 2D channel structures with affinity properties, which require complex fabrication but deliver suboptimal separation and detection performance. This study presents a novel vessel-like microtunnel chip, integrated with biomimetic octopus tentacles, achieving an exosome isolation efficiency of 90.4%. The innovative design incorporates interwoven, 3D micropathways, enhancing fluid dynamics and promoting efficient mixing between exosomes and microchannels. Nanofiber-coated silicon microspheres, functionalized with synthetic peptides, mimic octopus tentacles to anchor the microtunnels, dynamically extending under fluid shear forces to specifically recognize lipid bilayer structures for exosome capture. This platform incorporates enzyme-catalyzed signal amplification using Au nanoprobes for colorimetric detection to sensitively analyze four protein markers on plasma-derived exosomes from 60 clinical samples. Machine learning is used to develop a diagnostic model, achieving an area under the curve (AUC) of 0.9888 in distinguishing pancreatic cancer from pancreatitis and healthy controls. This approach provides a rapid, sensitive, accurate, and user-friendly method for pancreatic cancer diagnosis, addressing the clinical challenges of early detection and the frequent misdiagnosis of pancreatic cancer as pancreatitis.","PeriodicalId":228,"journal":{"name":"Small","volume":"120 1","pages":"e2502763"},"PeriodicalIF":13.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Polyoxymethylene Fiber-Based Artificial Muscle Enabled Stable Actuating Behavior. 一种新型聚氧亚甲基纤维人造肌肉实现了稳定的驱动行为。

IF 13.3 2区材料科学

Small Pub Date : 2025-05-27 DOI: 10.1002/smll.202502065

Weiyao Kong,Xiaowen Zhao,Lin Ye

{"title":"A Novel Polyoxymethylene Fiber-Based Artificial Muscle Enabled Stable Actuating Behavior.","authors":"Weiyao Kong,Xiaowen Zhao,Lin Ye","doi":"10.1002/smll.202502065","DOIUrl":"https://doi.org/10.1002/smll.202502065","url":null,"abstract":"Due to superior water/chemical resistance, constructing novel polyoxymethylene (POM) fiber-based artificial muscles (AM) is significant for developing advanced flexible actuating devices with high stability. However, strong crystallizing ability and low amorphous content of POM fibers were disadvantageous for them to achieve ideal actuating performance as artificial muscles. Herein, thermoplastic polyurethane elastomer (TPU) was blended with POM to regulate its crystalline behavior widely, while POM/TPU fibers were prepared by melt spinning-hot drawing/heat setting, and a mandrel-coiled POM fiber-based AM was constructed for the first time by further merged/twisted/coiled processes. With increasing fiber draw ratio/TPU content, the increased orientation factors/amorphous content of stretched POM fibers substantially enhanced the actuation properties of muscles. Meanwhile, by controlling merging/twisting/coiling geometries, the actuating properties of muscles are further optimized. Under 14 V actuating voltage/200 load-to-weight ratio, the max shrinkage strain/work capacity of POM/20T-600%f AM achieve 40.23%/34.69 J kg-1, reaching 201%/434% of those of typical mammalian skeletal muscle. Moreover, POM fiber-based AM exhibit superior cyclic actuating stability due to thermal stable oriented crystalline structures of fiber during the actuating process, while in alkali resistance tests, the maximum shrinkage strain retention reach 94.11%, much higher than that of nylon 66 sewing threads AM (53.56%).","PeriodicalId":228,"journal":{"name":"Small","volume":"17 1","pages":"e2502065"},"PeriodicalIF":13.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Zwitterionic Self‐Healing Polymer Electrolytes for Anode‐Free Lithium‐Metal Batteries: a Computational Perspective 用于无阳极锂金属电池的多功能两性离子自愈聚合物电解质：计算视角

IF 13.3 2区材料科学

Small Pub Date : 2025-05-27 DOI: 10.1002/smll.202503382

Liang‐Ting Wu, Yu‐Ting Zhan, Yu‐Cheng Chiu, Bing Joe Hwang, Jyh‐Chiang Jiang

{"title":"Multifunctional Zwitterionic Self‐Healing Polymer Electrolytes for Anode‐Free Lithium‐Metal Batteries: a Computational Perspective","authors":"Liang‐Ting Wu, Yu‐Ting Zhan, Yu‐Cheng Chiu, Bing Joe Hwang, Jyh‐Chiang Jiang","doi":"10.1002/smll.202503382","DOIUrl":"https://doi.org/10.1002/smll.202503382","url":null,"abstract":"The practical application of anode‐free lithium‐metal batteries (AFLMBs) is limited by their poor cycling performance and unstable solid electrolyte interphase (SEI). Self‐healing solid polymer electrolytes (SHSPEs) offer excellent flexibility and healing capabilities, which are expected to mitigate dendrite growth and improve AFLMB cycling performance. In this study, a novel zwitterionic SHSPE, P(SBMA‐co‐BA):LiTFSI, is proposed, and its suitability for AFLMBs is evaluated through density functional theory (DFT) and ab initio molecular dynamics (AIMD) simulations. The sulfonate (RSO3−) group promotes Li+ ion transport, and the electrostatic interaction between RSO3− and NR4+ groups drives the electrolyte's self‐healing after material damage. Electrolyte degradation on the Cu current collector during Li‐nucleation and on the Li metal surface during extensive Li metal plating is further examined. The SEI components are identified using atomic charge distribution analysis, which is typically compared with X‐ray photoelectron spectroscopy (XPS) data. The resulting organic/inorganic hybrid SEI demonstrates excellent flexibility and stability, and the long‐chain sulfonate‐containing compound facilitates rapid Li‐ion conduction and uniform Li metal plating. The multifunctional zwitterionic SHSPE, P(SBMA‐co‐BA):LiTFSI, thus shows significant potential to enhance the cycling performance of AFLMBs, paving the way for their practical application.","PeriodicalId":228,"journal":{"name":"Small","volume":"45 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bimodal Dissolving Microneedles with Nanoparticle Coating and Encapsulation for Extended Dual-Drug Delivery. 双峰溶解微针与纳米粒子涂层和封装扩展双药递送。

IF 13.3 2区材料科学

Small Pub Date : 2025-05-26 DOI: 10.1002/smll.202502904

Mingshan Li,Akmal H B Sabri,Nuoya Qin,Ke Peng,Marco Abbate,Alejandro J Paredes,Helen O McCarthy,Lalitkumar K Vora,Ryan F Donnelly

{"title":"Bimodal Dissolving Microneedles with Nanoparticle Coating and Encapsulation for Extended Dual-Drug Delivery.","authors":"Mingshan Li,Akmal H B Sabri,Nuoya Qin,Ke Peng,Marco Abbate,Alejandro J Paredes,Helen O McCarthy,Lalitkumar K Vora,Ryan F Donnelly","doi":"10.1002/smll.202502904","DOIUrl":"https://doi.org/10.1002/smll.202502904","url":null,"abstract":"Effective co-delivery of multiple drugs via microneedle (MN) platforms is challenging due to limited loading capacity and the need for sustained release. This study presents a bimodal coated-dissolving microneedle (DMN) patch for extended delivery of diclofenac (DCF) and dexamethasone (DSP) nanoparticles to treat osteoarthritis. The DMN tips are loaded with DCF nanoparticles (3.84 mg/patch) and coated with DSP-PLGA nanosuspensions (0.44 mg/patch), achieving dual-drug release from a single patch. Ex vivo studies in neonatal porcine skin show > 90% penetration into the stratum corneum (≈276 µm depth), with transdermal delivery of 1.54 mg DCF and 118 µg DSP at 24 h. In vivo pharmacokinetic studies in rats demonstrate sustained DCF plasma levels for 72 h, with an extended half-life (13.0 h) and 80.3% relative bioavailability compared to oral dosing. DSP exhibits a biphasic release, peaking at 24-30 h (227.7 ng mL-1, 63.9% bioavailability). High drug levels persist in skin and paw tissues for 72 h, suggesting prolonged local efficacy. These bimodal DMNs provide a high-loading, sustained-release platform for minimally invasive, patient-friendly dual-drug therapy, optimizing osteoarthritis treatment and improving compliance.","PeriodicalId":228,"journal":{"name":"Small","volume":"10 1","pages":"e2502904"},"PeriodicalIF":13.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defective Antifluorite MnO2-Layered RuO2 for Direct Seawater Electrolysis at Circum-Neutral pH. 缺陷反萤石mno2层状RuO2在环中性pH下的直接海水电解。

IF 13.3 2区材料科学

Small Pub Date : 2025-05-26 DOI: 10.1002/smll.202504249

Nan-Nan Liang,Dong Jin Kim,Zhiyu Qiu,Youngha Kweon,Tae Woo Kim,Dong Suk Han,Minho Kim,Hyunwoong Park

引用次数: 0

Small最新文献