Polyglycerol-Grafted Graphene Oxide with pH-Responsive Charge-Convertible Surface to Dynamically Control the Nanobiointeractions for Enhanced in Vivo Tumor Internalization (Small 40/2025)

IF 12.1 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2025-10-08 DOI:10.1002/smll.70739

Yajuan Zou, Alberto Bianco, Yuta Nishina

引用次数: 0

Abstract

Cancer Theranostics

In article number 2503029, Yajuan Zou, Alberto Bianco, and Yuta Nishina reveal that the in vivo fate of polyglycerol-grafted graphene oxide with pH-responsive charge-convertible surface depends on the density of the functional groups. Controlling the amounts of these functional groups allowed to achieve prolonged circulation and enhanced tumor cellular internalization. These findings will advance the design of pH-responsive nanomaterials for precise cancer theranostics.

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具有ph响应电荷转换表面的聚甘油接枝氧化石墨烯动态控制纳米生物相互作用以增强体内肿瘤内化（Small 40/2025）

《癌症治疗学》（Cancer theranostic）文章编号2503029中，邹亚娟、Alberto Bianco和Yuta Nishina揭示了具有ph响应电荷可转换表面的聚甘油接枝氧化石墨烯的体内命运取决于官能团的密度。控制这些官能团的数量可以延长循环并增强肿瘤细胞内化。这些发现将推动ph响应纳米材料的设计，用于精确的癌症治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.