Nano ResearchPub Date : 2026-07-01DOI: 10.26599/nr.2026.94908970
Hui Tao, Chaojing Li, Jing Lin, Tonghe Zhu, Lu Wang
{"title":"Bioactive nanofibers covered stent with matched mechanics and durable gemcitabine release for treating esophageal cancer","authors":"Hui Tao, Chaojing Li, Jing Lin, Tonghe Zhu, Lu Wang","doi":"10.26599/nr.2026.94908970","DOIUrl":"https://doi.org/10.26599/nr.2026.94908970","url":null,"abstract":"Abstract Developing a drug-eluting esophageal stent (DEES), which provides both mechanical support and local chemotherapy, represents a preferred treatment option for patients with advanced esophageal cancer. However, existing DEES have limitations such as drug loading via surface micro/nano-structures or physical blending of drugs into polymer covering, often lead to issues like initial burst release, short-lasting therapeutic effects, or compromised mechanical properties. To address the above challenges, we synthesized gemcitabine (GEM) blocked biodegradable polyurethane (PG) and then covered it around the surface of NiTi stent via electrospinning to form nanofibers covered stent. This electrospun PG nanofibers achieved firm adhesion without compromising the original mechanical integrity of NiTi stent. In vitro data demonstrated that the PG fibers presented prominent antitumor therapy effect and antiangiogenesis ability, as well as enabled degradation-associated drug release, resulting in less than 1% initial burst release within 24 hours and sustained release over 24 weeks. In vivo assessments indicated the PG fibers could continuously inhibit tumor growth by inducing tumor cell apoptosis and suppressing tumor angiogenesis. This study demonstrates the bioactive nanofibers covered stent with matched mechanics and durable efficacious antitumor, which could offer a potential strategy for treating esophageal cancer via local chemotherapy.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908970.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano ResearchPub Date : 2026-07-01DOI: 10.26599/nr.2026.94908993
Liancong Yue, Min Gong, Youyou Liu, Jianping Wang, Lekun Liu, Xiang Lin, Fengxian Gao, Liang Zhang, Dongrui Wang
{"title":"Hydration-adaptive and omnidirectionally stretchable silk/Ag@Au nanowire epidermal electrodes for unobtrusive long-term electrophysiological monitoring","authors":"Liancong Yue, Min Gong, Youyou Liu, Jianping Wang, Lekun Liu, Xiang Lin, Fengxian Gao, Liang Zhang, Dongrui Wang","doi":"10.26599/nr.2026.94908993","DOIUrl":"https://doi.org/10.26599/nr.2026.94908993","url":null,"abstract":"Abstract Achieving high-performance epidermal electrodes for long-term electrophysiological monitoring remains a significant challenge, as it necessitates a delicate balance between high electrical conductivity, optical transparency, mechanical compliance, and environmental stability within a single platform. Herein, we present a multifunctional epidermal bioelectrode (silk/Ag@Au BioE) fabricated by combining a silver-gold core-sheath nanowire (Ag@Au NW) network with a silk fibroin (SF) substrate via direct ink writing and solution-casting transfer techniques. The resulting electrode exhibits superior optical transmittance (up to 94.3%) and a low sheet resistance of 10.9 Ω/sq. A unique hydration-induced plasticization is employed to transform the initially rigid SF film into an ultra-soft, conformal skin interface. This process induces the spontaneous formation of micro-wrinkled architectures, which, in synergy with a meticulously designed second-order serpentine mesh, imparts exceptional omnidirectional stretchability and robust mechanical durability. The electrode also demonstrates high breathability (1591 g/(m2·day)), excellent resistance to sweat and oxidation, and sustainable reusability over multiple hydration-dehydration cycles. This integrated design enables high-fidelity, long-term monitoring of electrocardiogram (ECG), electromyogram (EMG), and electrooculogram (EOG) signals under dynamic and harsh conditions, substantially outperforming conventional Ag/AgCl electrodes. This work provides a versatile and robust material platform for next-generation wearable healthcare diagnostics.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908993.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microfluidic programmable sequential-release nanoparticles enhancing Icariside II–cisplatin synergy via cholesterol modulation in NSCLC","authors":"Liang Ye, Bing Yang, Zhi-Wei Xiong, Yixin Pan, Dandan Zhu, Shu-qi Hu, Ben-hong Li, Lu Gan, Hengyu Zhang, Bo-han Wang, Jian Li, Xiao-bin Jia, Liang Feng","doi":"10.26599/nr.2026.94908944","DOIUrl":"https://doi.org/10.26599/nr.2026.94908944","url":null,"abstract":"Abstract Combination chemotherapy is a cornerstone of non-small cell lung cancer (NSCLC) treatment, with cisplatin (CDDP) serving as a frontline agent, but its clinical utility is severely compromised by resistance and systemic toxicity. Overcoming these limitations requires both effective CDDP-sensitizing agents and delivery systems capable of precisely controlling drug ratios and release sequence. Here, we identified Icariside II (IS), a bioactive flavonoid from Epimedium species, as a potent CDDP sensitizer. Synergy analyses confirmed that IS and CDDP exert strong cooperative effects at a 1:2 molar ratio. Mechanistically, IS downregulated HMGCR/SREBF2, reduced intracellular cholesterol, and enhanced CDDP uptake and DNA damage, with IS pretreatment followed by CDDP producing the strongest antitumor effects. Guided by this mechanism, we engineered dual-drug polymer–lipid hybrid nanoparticles using a custom TrH microfluidic chip. Distinct from conventional methods, the TrH platform enabled programmable co-encapsulation with precise ratio control and intrinsic, stimulus-independent sequential release. Among the formulations, CDDP-IS@MNPs—programmed to release IS prior to CDDP—most effectively recapitulated the optimal sequence, inducing robust apoptosis in vitro, >70% tumor growth inhibition in xenografts, prolonged survival in orthotopic models, and reduced cisplatin-induced hepatic and renal toxicity. Collectively, compared with our previous formulation-oriented work, this study achieves a substantial conceptual advance by integrating mechanistic insight with programmable microfluidic design, transforming the TrH chip into a preclinically validated platform for stepwise nanomedicine delivery, while also providing a promising therapeutic strategy to address the long-standing challenges of cisplatin-based combination chemotherapy.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908944.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148394331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dual-plasmonic Cu <em> <sub>x</sub> </em> Sb <em> <sub>y</sub> </em> S/Cu heteronanostructures: Efficient photocatalysts for ammonia borane methanolysis dehydrogenation","authors":"Guoning Liu, Dan Wang, Yihe Zhu, ZENG Chaonan, 李予晋, Shaopeng Qi, Chongyi Ling, Xiuyun Zhang","doi":"10.26599/nr.2026.94908963","DOIUrl":"https://doi.org/10.26599/nr.2026.94908963","url":null,"abstract":"Abstract Plasmonic nanotubes are promising for photocatalysis due to their hollow structure, strong light−matter coupling, enhanced scattering, short charge paths, and abundant active sites. However, their synthesis is challenging, with few reports. Uniform CuxSbyS nanotubes and CuxSbyS/Cu dual-plasmonic heteronanostructures were synthesized via direct colloidal hot-injection by controlling reaction parameters. In ammonia borane methanol dehydrogenation, the heterostructure achieves a hydrogen production rate (690.17 mmol H2 g−1 cat. h−1) 5.5× higher than CuxSbyS nanotubes (126.21 mmol H2 g−1 cat. h−1) and 198.9× that of Cu nanoparticles (3.47 mmol H2 g−1 cat. h−1), demonstrating stability over 10 cycles. Synergistic effects drive activity: hollow structure improves light harvesting and surface exposure; CuxSbyS/Cu interface enables charge separation and transfer, reducing recombination; strong plasmonic absorption enhances photon utilization. Results confirm electron transfer from CuxSbyS to Cu, stabilizing nanoparticles and improving durability. Density functional theory identifies CH3OBH2NH3 desorption (not O−H cleavage) as the rate-determining step, offering new mechanistic insight. This method enables applications in solar hydrogen production, environmental purification, and energy-efficient conversion for sustainable energy and green chemistry.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908963.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148394563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficient NIR-II luminescence of inorganic Er-Yb alloyed nanocrystals for optical communication","authors":"Ruixiang Wu, Fengjie Guo, Zhiliang Han, Zixuan Wang, Peigeng Han, Bin Li, Rui Zhang, JunFeng Zhang, Xiangyang Miao, Chengbing Qin, Liantuan Xiao","doi":"10.26599/nr.2026.94908846","DOIUrl":"https://doi.org/10.26599/nr.2026.94908846","url":null,"abstract":"Abstract Zero-dimensional metal halides have emerged as a promising class of luminescent materials, attracting significant interest due to their unique electronic structures and fascinating optical characteristics. The photoluminescence (PL) properties of inorganic ternary Cs3ErxYb1−xCl6 nanocrystals (NCs) were investigated. These alloyed NCs emit dual-band near-infrared (NIR) PL, featuring a sharp NIR-II emission at 1543 nm alongside an NIR-I emission around 987 nm, which originate from the rare earth Er3+ and Yb3+ ions, respectively. Cs3Er0.06Yb0.94Cl6 NCs exhibit efficient NIR-II PL with a quantum yield of 2.7% and a lifetime of 157 µs. The enhanced NIR-II PL can be attributed to highly localized excitons, fast energy transfer from Yb3+ to Er3+ ions and passivation of nonradiative defect states in the Er-Yb alloyed NCs. Given their good penetrability of the NIR-II PL from Er3+ ions, a single-component NIR phosphor-converted light-emitting diode (pc-LED) fabricated using Cs3Er0.06Yb0.94Cl6 NCs demonstrates their potential for future applications in optical communication.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"19 10","pages":"94908846-94908846"},"PeriodicalIF":0.0,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908846.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano ResearchPub Date : 2026-05-01DOI: 10.26599/nr.2026.94908819
Xinting Yang, Jingjie Zhai, Chenke Wei, Yukai Guo, Bo Pan, Yang Bai, Yanmin Zhou, Quan Lin
{"title":"MXene-based hydrogel disrupt bacterial biofilms and reprogram immune cell metabolism via photothermal-electron transfer effects to reverse bone resorption in periodontitis","authors":"Xinting Yang, Jingjie Zhai, Chenke Wei, Yukai Guo, Bo Pan, Yang Bai, Yanmin Zhou, Quan Lin","doi":"10.26599/nr.2026.94908819","DOIUrl":"https://doi.org/10.26599/nr.2026.94908819","url":null,"abstract":"Bacterial biofilm colonization and persistent chronic inflammation in periodontitis cause periodontal tissue destruction and eventual tooth loss. Bacterial biofilms disruption and immune cell metabolism reprogramming are critical for the treatment of periodontitis. Herein, we developed an injectable MXene-based hydrogel (GQM), composed of oxidized gellan gum, quaternized chitosan, and magnesium–tannic acid–modified MXene nanosheets (MTA-Mg), which serves as a flexible scaffold for targeted delivery of MTA-Mg within periodontal pockets. The GQM hydrogels can be injected into periodontal pockets and targetly delivery MTA-Mg, which disrupt the dense biofilm efficiently by photothermal effect, while the bacteria are killed through the electrostatic interaction and charge neutralization from quaternized chitosan. MTA-Mg nanosheets serves interfacial electron transfer to activate oxidative phosphorylation pathway, while deliveries the magnesium and tannic acid to improve mitochondrial function, which reprogram the immune cell metabolism by inducing macrophage toward the M2 phenotype. The rat periodontitis model demonstrated that the GQM hydrogel effectively eradicates bacterial biofilms, alleviates inflammation, and reverses alveolar bone resorption, thereby the periodontitis is treated efficiently. All in all, the GQM hydrogel achieves a synergistic effect of “biofilm disruption–immune metabolic reprogramming” and offers a novel strategy for the reversal of inflammatory bone resorption in periodontitis.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simultaneous modulation of vacancy and heterointerface of double-matrix phosphorus doped NiSe <sub>2</sub> /CoSe <sub>2</sub> composite for “dual-core-driven” electromagnetic wave absorption","authors":"Yuhao Dong, Guangrong Wu, Zhenguo Gao, Di Lan, Hua Qiu, Zirui Jia, Guanglei Wu","doi":"10.26599/nr.2026.94908868","DOIUrl":"https://doi.org/10.26599/nr.2026.94908868","url":null,"abstract":"Abstract In order to achieve an efficient response of the absorber to electromagnetic waves (EMW), vacancy modulation and phase optimization of the composites are crucial. In this study, a phosphorus-doped vacancy modulation and phase interface optimization engineering was designed to prepare nine MOFs-derived metal selenides@carbon double matrix P-doped NiSe2/CoSe2@NC (PNCS). The optimal solution of the EMW absorber mechanism was explored by modulating the doping concentration and the calcination temperature. The selection of safeguarded priorities in this work is of constructive significance for the rationalization of EMW absorber preparation is constructive. Upon achieving a ratio of one third of the phosphorus source in the selenide matrix, the calcination temperature of 400 ℃ introduces moderate defects, thus providing the sample with optimal EMW absorption capabilities. With a maximum effective absorption bandwidth of 7.04 GHz at an ultra-thin matching thickness of 2.1 mm. This value covers the entire X and Ku bands within a usable thickness of 2.6 mm, which is significantly superior to other samples of the same type samples. The “dual-core-driven” strategy of heterogeneous interfaces and oxygen vacancies optimizes dielectric relaxation and polarization, supporting a prospective effect on the development and wide application of novel EMW absorbers.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Astragalus polysaccharide loaded MF59 adjuvant system enhances vaccine-induced cellular immune responses","authors":"Ying Zhu, Sijie Wang, Huanli Zhou, Yin Lu, Yitao Zhang, Xuemeng Guo, Qin Lin, Jiaxin Huang, Junlei Zhang, 罗利华, Chunqi Zhu, Jian You","doi":"10.26599/nr.2026.94908705","DOIUrl":"https://doi.org/10.26599/nr.2026.94908705","url":null,"abstract":"Abstract Vaccine adjuvants play a pivotal role in enhancing immune responses, but traditional adjuvants such as MF59 primarily induce humoral immunity and exhibit limited ability to activate CD8+ T cell-mediated cellular immunity. To address this critical gap, we strategically integrated Astragalus polysaccharide (APS), a biocompatible and immunomodulatory traditional Chinese medicine-derived polysaccharide, into the MF59 platform to construct a synergistic nano-adjuvant system (AMF59). This rationally designed adjuvant leverages the complementary properties of both components to enhance dendritic cell (DC) activation, facilitate antigen uptake and cross-presentation, and potently boost CD8+ T cell-mediated cellular immunity. In prophylactic tumor challenge studies, the OVA@AMF59 nanovaccine demonstrated potent immunoprotection and significantly suppressed tumor progression. Collectively, this work establishes a rational design strategy for next-generation vaccine adjuvants tailored to applications requiring potent cellular immunity.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"19 8","pages":"94908705-94908705"},"PeriodicalIF":0.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908705.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}