Nano Research最新文献

{"title":"Pressure-responsive pH-triggered layer-by-layer coating of paclitaxel-eluting balloon catheters for instant high-dose drug delivery for percutaneous coronary artery intervention","authors":"Jeong Yu Lee,&nbsp;Shonit Nair Sharma,&nbsp;Sung-Yu Hong,&nbsp;Young-Guk Ko,&nbsp;Yangsoo Jang,&nbsp;Minjae Do,&nbsp;Michael Christopher Stark,&nbsp;Qiwen Peng,&nbsp;Benjamin Allen Mossburg,&nbsp;Bo Chan Seo,&nbsp;Yuhan Lee","doi":"10.1007/s12274-024-6979-5","DOIUrl":"10.1007/s12274-024-6979-5","url":null,"abstract":"<div><p>Cardiovascular diseases remain the leading cause of mortality worldwide, with percutaneous coronary interventions (PCI) using drug-eluting stents (DES) as the standard treatment for coronary artery disease. Despite advancements in DES technology, challenges such as restenosis and stent thrombosis still necessitate further interventions and carry considerable risks, highlighting an urgent need for a novel therapeutic approach with lower restenosis rates and reduced reintervention risks. Drug-eluting balloons (DEBs) coated with anti-proliferative agents offer a novel method of local drug delivery for reducing restenosis by directly administering drugs to the lesion site. However, efficient delivery of drugs within the brief procedural window while minimizing drug loss during maneuvering to the target site remains a challenge. Herein, we developed a pressure-responsive and pH-triggered, paclitaxel (PTX) coated DEB catheter for rapid and high-dose delivery of paclitaxel to the lesion sites, overcoming the limitations of drug dispersion and inefficiencies associated with conventional DEBs. Using the charge reversion of albumin around its isoelectric point, paclitaxel-loaded human serum albumin nanoparticles (PTX-HSA-NPs) and heparin were coated using a layer-by-layer deposition method at pH 4.0. Upon exposure to physiological pH (i.e., 7.4), the coating is rapidly released from the balloon surface. Combined with a protective shellac coating, the DEB achieved controlled release of high-dose paclitaxel to the arterial tissue <i>in vivo</i> (up to 400 µg per gram tissue), exceeding current DEBs in the clinic. These results suggest the pH-responsive, multi-layer coated DEB’s potential for superior procedural outcomes, addressing a critical unmet need in PCI.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 10","pages":"9141 - 9151"},"PeriodicalIF":9.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative hydrogel-based delivery systems for immunotherapy: A review of pre-clinical progress","authors":"Narsimha Mamidi,&nbsp;Michael Poellmann,&nbsp;Kaila Javius-Jones,&nbsp;KiChang Nam,&nbsp;Seungpyo Hong","doi":"10.1007/s12274-024-6980-z","DOIUrl":"10.1007/s12274-024-6980-z","url":null,"abstract":"<div><p>Immunotherapy has markedly reinvented how we treat cancer, as shown by numerous Food and Drug Administration (FDA) drug approvals that have made significant clinical impact and ongoing clinical trials. However, undesirable side effects, such as autoimmunity and inflammation, and inconsistent clinical outcomes remain a major challenge. Improving response rates across various immunotherapeutic reagents is imperative to enhance overall effectiveness and reduce adverse side effects. To address this challenge, interdisciplinary approaches have been explored by incorporating immunotherapies into hydrogels, enabling fine-controlled delivery to target tissues. This review focuses on recent progress in the utilization of hydrogel-based delivery systems for cancer immunotherapy and their potential to further enhance treatment response rates. Specifically, recent preclinical advances in hydrogels implemented with immune checkpoint inhibitors, combination therapies, and vaccines, along with self-assembled peptide hydrogels, are reviewed. We also discuss technological advances and drawbacks in this area and provide insights to ultimately realize the clinical application of hydrogels in cancer immunotherapy.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 10","pages":"9031 - 9043"},"PeriodicalIF":9.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Processing of molybdenum industrial waste into sustainable and efficient nanocatalysts for water electrolysis reactions","authors":"Federico Ursino,&nbsp;Giacometta Mineo,&nbsp;Antonino Scandurra,&nbsp;Mario Scuderi,&nbsp;Angelo Forestan,&nbsp;Catya Alba,&nbsp;Riccardo Reitano,&nbsp;Antonio Terrasi,&nbsp;Salvo Mirabella","doi":"10.1007/s12274-024-6972-z","DOIUrl":"10.1007/s12274-024-6972-z","url":null,"abstract":"<div><p>The increasing need for sustainable energy and the transition from a linear to a circular economy pose great challenges to the materials science community. In this view, the chance of producing efficient nanocatalysts for water splitting using industrial waste as starting material is attractive. Here, we report low-cost processes to convert Mo-based industrial waste powder into efficient catalysts for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). pH controlled hydrothermal processing of Mo-based industrial waste powder leads to pure orthorhombic MoO₃ nanobelts (50–200 nm wide, 10 µm long) with promising OER performances at 10 mA·cm⁻² with an overpotential of 324 mV and Tafel slope of 45 mV·dec⁻¹ in alkaline electrolyte. Indeed, MoS₂/MoO₃ nanostructures were obtained after sulfurization during hydrothermal processes of the MoO₃ nanobelts. HER tests in acidic environment show a promising overpotential of 208 mV at 10 mA·cm⁻² and a Tafel slope of 94 mV·dec⁻¹. OER and HER performances of nanocatalysts obtained from Mo industrial waste powder are comparable or better than Mo-based nanocatalysts obtained from pure commercial Mo reagent. This work shows the great potential of reusing industrial waste for energy applications, opening a promising road to join waste management and efficient and sustainable nanocatalysts for water splitting.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 11","pages":"9585 - 9593"},"PeriodicalIF":9.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12274-024-6972-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microcavity assisted graphene pressure sensor for single-vessel local blood pressure monitoring","authors":"Jinan Luo, Jingzhi Wu, Xiaopeng Zheng, Haoran Xiong, Lin Lin, Chang Liu, Haidong Liu, Hao Tang, Houfang Liu, Fei Han, Zhiyuan Liu, Zhikang Deng, Chuting Liu, Tianrui Cui, Bo Li, Tian-Ling Ren, Jianhua Zhou, Yancong Qiao","doi":"10.1007/s12274-024-6969-7","DOIUrl":"https://doi.org/10.1007/s12274-024-6969-7","url":null,"abstract":"<p>Dynamic monitoring of blood pressure (BP) is beneficial to obtain comprehensive cardiovascular information of patients throughout the day. However, the clinical BP measurement method relies on wearing a bulky cuff, which limits the long-term monitoring and control of BP. In this work, a microcavity assisted graphene pressure sensor (MAGPS) for single-vessel local BP monitoring is designed to replace the cuff. The microcavity structure increases the working range of the sensor by gas pressure buffering. Therefore, the MAGPS achieves a wide linear response of 0–1050 kPa and sensitivity of 15.4 kPa⁻¹. The large working range and the microcavity structure enable the sensor to fully meet the requirements of BP detection at the radial artery. A database of 228 BP data (60-s data fragment detected by MAGPS) and 11,804 pulse waves from 9 healthy subjects and 5 hypertensive subjects is built. Finally, the BP was detected and analyzed automatically by combining MAGPS and a two-stage convolutional neural network algorithm. For the BP detection method at local radial artery, the first stage algorithm first determines whether the subject has hypertension by the pulse wave. Then, the second stage algorithm can diagnose systolic and diastolic BP with the accuracy of 93.5% and 97.8% within a 10 mmHg error, respectively. This work demonstrates a new BP detection method based on single vessel, which greatly promotes the efficiency of BP detection.\u0000</p>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"10 1","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in photocatalytic CO2 cycloaddition reaction","authors":"Xing Chen,&nbsp;Ye Liu,&nbsp;Guoqiang Wang,&nbsp;Yubo Kuang,&nbsp;Xiaoqian Xiang,&nbsp;Guangran Di,&nbsp;Xiaojing Yin,&nbsp;Lei Zhang,&nbsp;Kaixin Wang,&nbsp;Qianqian Cai,&nbsp;Xiaojun Lv","doi":"10.1007/s12274-024-6953-2","DOIUrl":"10.1007/s12274-024-6953-2","url":null,"abstract":"<div><p>Carbon dioxide (CO₂) is a principal greenhouse gas with a substantial impact on global climate change. The photocatalytic reduction of CO₂ represents an economically viable and environmentally benign approach. This technique involves the catalysis of the reaction between CO₂ and epoxides under photocatalytic conditions to yield cyclic carbonates. Notably, this process has garnered significant attention due to its high atomic efficiency and alignment with green chemistry principles. Increasingly, photocatalysts are employed to facilitate the synthesis of cyclic carbonates, demonstrating outstanding performance even under natural light. This review evaluates the current state of research on the photocatalytic cycloaddition of CO₂ with epoxides, analyzes the reaction mechanism and key influencing factors, and provides a comparative summary of the photocatalysts developed in this domain. Additionally, this paper underscores the significance of the reaction devices. The paper explores reaction devices with potential applications for photocatalytic CO₂ and epoxides and envisions future integrations of CO₂ photocatalytic cycloaddition reactions with advanced reaction devices for practical applications in this area.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 11","pages":"9601 - 9619"},"PeriodicalIF":9.5,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142227321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catalytic recycling of plastics into value-added products","authors":"Tianyu Wei,&nbsp;Pengcheng Zhou,&nbsp;Wenxian Liu,&nbsp;Xijun Liu,&nbsp;Tairong Kuang","doi":"10.1007/s12274-024-6955-0","DOIUrl":"10.1007/s12274-024-6955-0","url":null,"abstract":"<div><p>The overuse and ineffective management of plastics have led to significant environmental pollution. Catalytic upcycling into value-added chemicals has emerged as a promising solution. This review provides a comprehensive overview of recent advances in catalytic upcycling, focusing on the cleavage of chemical bonds such as carbon-carbon (C-C), carbon-oxygen (C-O), and carbon-hydrogen (C-H) in plastics. It systematically discusses plastics conversion via electrocatalysis, thermal catalysis, and photocatalysis. Additionally, it explores the conversion of plastics into value-added chemicals and functional polymers. The review also addresses the challenges in this field and aims to offer insights for developing sustainable and effective plastics upcycling technologies.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 11","pages":"9428 - 9445"},"PeriodicalIF":9.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Size hierarchy of gold clusters in nanogold-catalyzed acetylene hydrochlorination","authors":"Yifei Zhang,&nbsp;Xinrui Gu,&nbsp;Fatimah Kehinde Busari,&nbsp;Sami Barkaoui,&nbsp;Zhong-Kang Han,&nbsp;Alfons Baiker,&nbsp;Zhen Zhao,&nbsp;Gao Li","doi":"10.1007/s12274-024-6976-8","DOIUrl":"10.1007/s12274-024-6976-8","url":null,"abstract":"<div><p>Size hierarchy is a distinct feature of nanogold-catalysts as it can strongly affect their performance in various reactions. We developed a simple method to generate Au_<i>n</i>S_<i>m</i> nanoclusters of different sizes by thermal treatment of an Au₁₄₄(PET)₆₀ (PET: phenylethanethiol) parent cluster. These clusters, deposited on activated carbon, exhibit excellent catalytic performance in the hydrochlorination of acetylene. _In-situ ultraviolet laser dissociation high-resolution mass spectrometry of the parent cluster in the presence of acetylene revealed a remarkable cluster size-dependence of acetylene adsorption, which is a crucial step in the hydrochlorination. Systematic density functional theory calculations of the reaction pathways on the differently-sized clusters provide deeper insight into the cluster size dependence of the adsorption energies of the reactants and afforded a scaling relationship between the adsorption energy of acetylene and the co-adsorption energies of the reactants (C₂H₂ and HCl), which could enable a qualitative prediction of the optimal Au_<i>n</i>S_<i>m</i> cluster for the hydrochlorination of acetylene.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 11","pages":"9594 - 9600"},"PeriodicalIF":9.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expediting carbon dots synthesis by the active adaptive method with machine learning and applications in dental diagnosis and treatment","authors":"Yaoyao Tang, Quan Xu, Xinyao Zhang, Rongye Zhu, Nuo Zhao, Juncheng Wang","doi":"10.1007/s12274-024-6946-1","DOIUrl":"https://doi.org/10.1007/s12274-024-6946-1","url":null,"abstract":"<p>Synthesis of functional nanostructures with the least number of tests is paramount towards the propelling materials development. However, the synthesis method containing multivariable leads to high uncertainty, exhaustive attempts, and exorbitant manpower costs. Machine learning (ML) burgeons and provokes an interest in rationally designing and synthesizing materials. Here, we collect the dataset of nano-functional materials carbon dots (CDs) on synthetic parameters and optical properties. ML is applied to assist the synthesis process to enhance photoluminescence quantum yield (QY) by building the methodology named active adaptive method (AAM), including the model selection, max points screen, and experimental verification. An interactive iteration strategy is the first time considered in AAM with the constant acquisition of the furnished data by itself to perfect the model. CDs exhibit a strong red emission with QY up to 23.3% and enhancement of around 200% compared with the pristine value obtained through the AAM guidance. Furthermore, the guided CDs are applied as metal ions probes for Co²⁺ and Fe³⁺, with a concentration range of 0–120 and 0–150 µM, and their detection limits are 1.17 and 0.06 µM. Moreover, we also apply CDs for dental diagnosis and treatment using excellent optical ability. It can effectively detect early caries and treat mineralization combined with gel. The study shows that the error of experiment verification gradually decreases and QY improves double with the effective feedback loops by AAM, suggesting the great potential of utilizing ML to guide the synthesis of novel materials. Finally, the code is open-source and provided to be referenced for further investigation on the novel inorganic material prediction.</p>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"460 1","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142227325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulating electrochemical performance of Cu7S4 electrodes via ligand engineering in copper cluster precursors","authors":"Zhou Wu,&nbsp;Lu-Fan Wang,&nbsp;Xiao-Fei Liu,&nbsp;Ren-Wu Huang,&nbsp;Rui Wang,&nbsp;Guoqiang Sun,&nbsp;Shuang-Quan Zang","doi":"10.1007/s12274-024-6956-z","DOIUrl":"10.1007/s12274-024-6956-z","url":null,"abstract":"<div><p>Cu-based chalcogenide materials exhibit significant promise for the development of Zn-metal-free anode materials for aqueous Zn-ion batteries (AZIBs). Here, we present the establishment of an efficient and universal strategy that capitalizes on the pyrolysis of copper nanoclusters to fabricate conversion-type Cu₇S₄ anodes engineered for AZIBs, showcasing outstanding electrochemical performance. Furthermore, by exploiting ligand engineering, we enable the precise control of both the type of molecular fragments generated during nanocluster pyrolysis, thus enabling the manipulation of vacancy concentrations and ion/electron migration in the resultant pyrolysis products. In contrast to the direct pyrolysis of metal salts and ligands, the products derived from copper nanoclusters exhibit enhanced specific capacity, rate performance, and overall stability. This research offers valuable insights for the development of novel electrode materials through the pyrolysis of atomically precise nanoclusters.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 11","pages":"9746 - 9755"},"PeriodicalIF":9.5,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142227334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defect engineering and Ni promoter synergistically accelerating electron transfer to Ru0 sites in UiO-66(Ce) for dicyclopentadiene hydrogenation under mild condition","authors":"Rushuo Li,&nbsp;Tao Ban,&nbsp;Danfeng Zhao,&nbsp;Jing Lin,&nbsp;Zhiyuan Liu,&nbsp;Linmeng Wang,&nbsp;Xiubing Huang,&nbsp;Zhiping Tao,&nbsp;Ge Wang","doi":"10.1007/s12274-024-6954-1","DOIUrl":"10.1007/s12274-024-6954-1","url":null,"abstract":"<div><p>Olefin hydrogenation under mild condition is crucial and challenging for industrial applications. Herein, defective UiO-66(Ce) was constructed by using cyanuric acid as the molecular etching “scissors” and further to synthesize heterogeneous catalyst with highly dispersed RuNi nanoparticles (Ru₁Ni_1.5@UiO-66(Ce)-12 h). The construction of Ce-O-Ru/Ni heterogeneous interfaces and Ni–Ru bonds provide electron transfer channels from Ce-oxo clusters and Ni species to Ru species. Furthermore, the microenvironment and electronic structure of Ru⁰ active sites were synergistically regulated by adjusting the content of metal-organic frameworks (MOFs) defects and Ni promoter, thereby enhancing the adsorption and activation ability of H–H and C=C bonds. Therefore, Ru₁Ni_1.5@UiO-66(Ce)-12 h achieved dicyclopentadiene saturated hydrogenation (100% conversion) to tetrahydrodicyclopentadiene (∼ 100% selectivity) under mild condition (35 °C, 1 MPa) with only 25 min. Meanwhile, the sample exhibited excellent structural stability after 6 cycles test. This study provides a promising strategy for the rational design of remarkable noble metal-based catalysts for practical applications.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"17 11","pages":"9550 - 9563"},"PeriodicalIF":9.5,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}