Nano Research最新文献_第2页

Multicomponent nanoassembly integrating photosensitizer and Astragalus polysaccharide adjuvant for amplified photoimmunotherapy via hypoxia adaptation disruption 整合光敏剂和黄芪多糖佐剂的多组分纳米组件通过缺氧适应破坏放大光免疫治疗

2区材料科学

Nano Research Pub Date : 2026-03-01 DOI: 10.26599/nr.2026.94908620

Chenjing Zhao, Yun Zhang, Xinrui Bao, Hexin Gong, Ze Shan Wu, Wenwen Zang, Jinghong Hu, Zhen Dong, Tengfei Ji

{"title":"Multicomponent nanoassembly integrating photosensitizer and Astragalus polysaccharide adjuvant for amplified photoimmunotherapy via hypoxia adaptation disruption","authors":"Chenjing Zhao, Yun Zhang, Xinrui Bao, Hexin Gong, Ze Shan Wu, Wenwen Zang, Jinghong Hu, Zhen Dong, Tengfei Ji","doi":"10.26599/nr.2026.94908620","DOIUrl":"https://doi.org/10.26599/nr.2026.94908620","url":null,"abstract":"Photoimmunotherapy (PIT) employs photosensitizers that generate reactive oxygen species (ROS) under near-infrared laser irradiation to induce immunogenic cell death (ICD) and trigger systemic antitumor immunity. However, the hypoxic conditions within tumors markedly reduce photosensitization efficiency and therapeutic efficacy. Moreover, insufficient immune activation together with the profoundly suppressive tumor immune microenvironment further compromises treatment outcomes. Given these challenges, it is imperative to develop an integrated therapeutic platform capable of effectively overcoming these limitations. Here, a responsive delivery system has been developed that utilizes ROS and incorporates the immunomodulatory agent Astragalus polysaccharide (APS). Hydrophobic rapamycin (RAPA) is linked to the APS backbone through a ROS-sensitive thioether TK bond, forming the amphiphilic APS-TK-RAPA (ATKR) conjugate. Subsequently, the photosensitizer 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) is integrated into the system. The designed ATKR conjugate carrier facilitates the maturation of dendritic cells (DCs), effectively captures antigens released during PDT, and enhances antigen presentation. This further amplifies the adaptive immune response mediated by the APS-based carrier, thereby strengthening antitumor efficacy. In summary, ATKR with superior biocompatibility, effectively surmounts the delivery challenges of hydrophobic photosensitizers. Moreover, it offers a promising nanoscale platform to address the critical issue of hypoxia in photodynamic therapy for cancer, serving as an effective inducer for augmenting immune responses.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908620.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Architecting nanoconfined multiphase gels as a reprocessable and multistimuli-responsive 4D printing platform 构建纳米限制多相凝胶作为可再处理和多刺激响应的4D打印平台

2区材料科学

Nano Research Pub Date : 2026-03-01 DOI: 10.26599/nr.2026.94908644

Zewei Li, Yuzhu Cui, Shihao Zhou, Zongshu Li, Mingliang Zhao, Shuxue Wang, Yongxin Duan, Jianming Zhang, Lu Zong

{"title":"Architecting nanoconfined multiphase gels as a reprocessable and multistimuli-responsive 4D printing platform","authors":"Zewei Li, Yuzhu Cui, Shihao Zhou, Zongshu Li, Mingliang Zhao, Shuxue Wang, Yongxin Duan, Jianming Zhang, Lu Zong","doi":"10.26599/nr.2026.94908644","DOIUrl":"https://doi.org/10.26599/nr.2026.94908644","url":null,"abstract":"4D printed shape memory gels (SMGs) have shown great potential for bionic scaffolds and soft robotics. However, their practical deployment is often limited by insufficient mechanical strength and reprocessability. Here, a nanoconfined multiphase gel strategy to develop reprocessable and multistimuli-responsive 4D-printed SMGs is proposed. The developed poly(vinyl alcohol)/chitin nanocrystals/paraffin multiphase gel (PCPG) employs zwitterionic chitin nanocrystals (ChNC) as an interfacial stabilizer to construct a nanoconfined environment, mediated by abundant interfacial interactions—hydrophobic with the paraffin (PW) microphase and hydrogen bonding with the poly(vinyl alcohol) (PVA) gel matrix. These synergistic interactions lead to a remarkable enhancement in tensile strength (by ≈ 50%, up to ~ 1 MPa). A high loading of phase-change PW (volume fraction >70%) imparts outstanding shape memory properties and printability, with fixation and recovery ratios both exceeding 95%, along with high responsiveness to both thermal and acoustic stimuli. Importantly, the dynamically crosslinked network combined with efficient nanoconfinement enables excellent reprocessability, the 4D-printed PCPG retains over 85% of its original mechanical and shape memory performance after ten reprocessing cycles. This strategy successfully merges nanoconfinement design with reprocessability, providing a sustainable platform for high-performance 4D-printed bionic scaffolds.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908644.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant SRS signal enhancements from near-infrared cumulenes 来自近红外积雨云的巨大SRS信号增强

2区材料科学

Nano Research Pub Date : 2026-02-15 DOI: 10.26599/nr.2026.94908576

X. Bai, Tiantian Dong, Fanghao Hu

引用次数: 1

Upconverted microrobots alleviate the idiopathic pulmonary fibrosis via improving the respiratory depression 上转化微型机器人通过改善呼吸抑制减轻特发性肺纤维化

2区材料科学

Nano Research Pub Date : 2026-02-01 DOI: 10.26599/nr.2026.94908538

Hua Liu, Kaige Zheng, Mingzhu Yang, Qixiang Zhang, Fengqin Zhao, Xuejiao Zeng, Yanbo Yang, Wei Gao, Na Yin, Jinjin Shi, Zhi-Hao Wang

{"title":"Upconverted microrobots alleviate the idiopathic pulmonary fibrosis via improving the respiratory depression","authors":"Hua Liu, Kaige Zheng, Mingzhu Yang, Qixiang Zhang, Fengqin Zhao, Xuejiao Zeng, Yanbo Yang, Wei Gao, Na Yin, Jinjin Shi, Zhi-Hao Wang","doi":"10.26599/nr.2026.94908538","DOIUrl":"https://doi.org/10.26599/nr.2026.94908538","url":null,"abstract":"Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive pulmonary disorder characterized by fibrotic scarring, hypoxemia, and dyspnea. Although oxygen therapy is widely used to relieve acute dyspnea, it faces limitations such as oxygen toxicity and patient immobility. To address these challenges, this study developed upconversion-based microrobots capable of mitigating IPF through in situ oxygen generation. These microrobots consist of Chlamydomonas reinhardtii algae functionalized with upconversion nanoparticles. Upon inhalation and exposure to near-infrared light, the microrobots convert the incident light into red visible light, driving photosynthetic oxygen production at a rate of 0.298 ± 0.005 mg (L·min)-1. Moreover, their autonomous mobility within the mucus enhances the uniformity of oxygen distribution and prolongs retention by evading pulmonary macrophage clearance. In a murine model of IPF, the microrobots effectively alleviated hypoxia, as evidenced by reduced HIF-1α expression in fibrotic lung tissues and elevated blood oxygen saturation. This platform presents an efficient and promising strategy for oxygen therapy in IPF and broader pulmonary oxygen-dependent applications.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908538.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mononuclear phagocyte system blockade for enhanced liposome-assisted metabolic glycan labeling and circulating biomarker detection in mice 单核吞噬细胞系统阻断增强脂质体辅助代谢糖标记和循环生物标志物检测小鼠

2区材料科学

Nano Research Pub Date : 2026-01-30 DOI: 10.26599/nr.2026.94908501

Pingping Feng, Tingbi Zhao, Rundong He, Lin Gan, Guangyu Hu, Xing Chen, Peng Dai

{"title":"Mononuclear phagocyte system blockade for enhanced liposome-assisted metabolic glycan labeling and circulating biomarker detection in mice","authors":"Pingping Feng, Tingbi Zhao, Rundong He, Lin Gan, Guangyu Hu, Xing Chen, Peng Dai","doi":"10.26599/nr.2026.94908501","DOIUrl":"https://doi.org/10.26599/nr.2026.94908501","url":null,"abstract":"The rapid clearance of nanoparticles by the mononuclear phagocyte system (MPS) severely compromises nanocarrier delivery efficiency and reduces the isolation yield of circulating biomarkers such as nucleosome-bound cell-free DNA (cfDNA) and exosomes. While liposome-based preconditioning is a promising strategy for transient MPS blockade, effective formulations remain scarce. Here, we report a potent MPS-blocking liposome (the Blocker) identified through an integrated screening strategy combining in vitro Kupffer cell uptake assays with in vivo biodistribution profiling. Notably, even upon co-administration, the Blocker effectively extended the circulation half-life of a widely used FDA‑approved PEGylated liposomal carrier by 2.1 folds, based on which liposome-assisted metabolic glycan labeling was significantly enhanced in a mouse tumor model. Furthermore, liposomal MPS blockade markedly inhibited the clearance of endogenous circulating cfDNA and exosomes, leading to a 6.8-fold increase in recovered cfDNA yield. This work highlighted liposomal blockade as a versatile platform for improving nanoparticle delivery and liquid biopsy sensitivity.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"19 4","pages":"94908501-94908501"},"PeriodicalIF":0.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908501.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymer microsphere-confined in-situ growth of MOF-303@poly(acrylate) composites for rapid atmospheric water harvesting under arid conditions 聚合物微球限制原位生长MOF-303@poly（丙烯酸酯）复合材料在干旱条件下的快速大气集水

2区材料科学

Nano Research Pub Date : 2026-01-21 DOI: 10.26599/nr.2026.94908458

Mengchen Li, Shunlong Xu, Jinpu Liang, Hong Meng, Guolei Xiang, Jianguo Mi, Junsu Jin, Junteng Liu

{"title":"Polymer microsphere-confined in-situ growth of MOF-303@poly(acrylate) composites for rapid atmospheric water harvesting under arid conditions","authors":"Mengchen Li, Shunlong Xu, Jinpu Liang, Hong Meng, Guolei Xiang, Jianguo Mi, Junsu Jin, Junteng Liu","doi":"10.26599/nr.2026.94908458","DOIUrl":"https://doi.org/10.26599/nr.2026.94908458","url":null,"abstract":"Metal-organic frameworks (MOFs) have emerged as exceptional materials for atmospheric water harvesting (AWH) due to their superior adsorption properties in low humidity conditions (≤20% RH), but most MOF adsorbents typically exist in powder form, thus their aggregation induces significant transfer resistance to limit their adsorption kinetics and practical application potential. Here we prepared an organic-inorganic MOF-303@poly(acrylates) composite by in-situ growing MOF-303 within porous poly(acrylates) spheres. Our results demonstrate that the 87% loading of MOF-303@poly(acrylates) exhibits uniformly dispersed crystals with a crystal size that is 40% smaller compared to pure MOF-303 powder, while maintaining a water vapor adsorption capacity of 0.348 g g-1 at 20% RH and 298 K, which is comparable to that of an equivalent mass of the pure MOF-303 powder. In the dynamic water vapor test with a constant flow rate (50 mL min-1), the adsorption and desorption rates of the composite are 2.74 times and 2 times faster than those of MOF-303 powder. After 100 consecutive adsorption and desorption cycles at 1780 mL min-1 (0.95 m s-1, light air), the water vapor adsorption capacity showed no significant decline. This composite strategy not only enhances adsorption kinetics but also advances MOF-based AWH systems for engineering applications.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"19 4","pages":"94908458-94908458"},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147896175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Halogen substitution with subtle effects on the electronic structure of fully conjugated molecular junctions 卤素取代对全共轭分子结的电子结构有细微影响

2区材料科学

Nano Research Pub Date : 2026-01-21 DOI: 10.26599/nr.2026.94908462

Shengzhe Qiu, Ningyue Chen, Zhenghao Wang, Jin‐Liang Lin, Yu Xie, Dezhuang Ji, Ziming Zhou, Sitong Liu, Wenkun Lv, Yuan Li

{"title":"Halogen substitution with subtle effects on the electronic structure of fully conjugated molecular junctions","authors":"Shengzhe Qiu, Ningyue Chen, Zhenghao Wang, Jin‐Liang Lin, Yu Xie, Dezhuang Ji, Ziming Zhou, Sitong Liu, Wenkun Lv, Yuan Li","doi":"10.26599/nr.2026.94908462","DOIUrl":"https://doi.org/10.26599/nr.2026.94908462","url":null,"abstract":"Halogen atoms possess distinct atomic polarizabilities and have been recently employed in molecular junctions composed of saturated alkanethiol to greatly enhancing tunneling currents, dielectric responses, and plasmonic properties. However, their influence in fully conjugated molecular systems remains insufficiently understood. Here, a series of conjugated molecules, HSCH2TPDA-X (X = H, F, Cl, Br, I), based on the fully conjugated triphenyldiacetylene (TPDA, = C6H4C≡CC6H4C≡CC6H4) backbone were designed, and Metal (Ag/Au)-SAMs//Eutectic gallium-indium alloy (EGaIn) molecular junctions were constructed to systematically investigate how halogen substitution affects charge transport in conjugated systems. The J-V characteristics of the HSCH2TPDA-X molecules remain stable over the measured temperature range, exhibiting temperature-independent behavior that indicates a tunneling-dominated charge transport mechanism. SLM fitting reveals that halogen substitution (X = H, F, Cl, Br, I) does not significantly alter the HOMO-Fermi level alignment, while the coupling strength is positively correlated with the current density. Density-functional theory (DFT) density-of-states (DOS) analysis reveals that, despite local terminal orbital shifts induced by halogen substitution, the overall DOS of the metal–self-assembled monolayer (SAM) closely follows that of the TPDA π-backbone, indicating a π-conjugated backbone pinning effect that constrains halogen-induced perturbations. These results contrast with previous saturated systems and indicate an observation of strong π-backbone pinning effect in conjugated system.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"19 4","pages":"94908462-94908462"},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147916393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-entropy layered hydroxide nanocatalysts via in-situ etching-growth of ZIF-67 for robust hydrogen generation from concentrated NaBH ₄ solution 高熵层状氢氧化物纳米催化剂的原位蚀刻生长- ZIF-67在浓缩NaBH - 4溶液中稳定产氢

2区材料科学

Nano Research Pub Date : 2026-01-21 DOI: 10.26599/nr.2026.94908464

Xin Chen, Zhenyu Wang, Hui Yao, Mingjie Jia, Yiming Wang, Die Shao, Na Ju, Yao Wang, Zilong Liu, Guangwen Xu, Yongjian Ai, Hongbin Sun

{"title":"High-entropy layered hydroxide nanocatalysts via in-situ etching-growth of ZIF-67 for robust hydrogen generation from concentrated NaBH 4 solution","authors":"Xin Chen, Zhenyu Wang, Hui Yao, Mingjie Jia, Yiming Wang, Die Shao, Na Ju, Yao Wang, Zilong Liu, Guangwen Xu, Yongjian Ai, Hongbin Sun","doi":"10.26599/nr.2026.94908464","DOIUrl":"https://doi.org/10.26599/nr.2026.94908464","url":null,"abstract":"Sodium borohydride (NaBH4) solution is a promising liquid \"fuel\" for continuous hydrogen supply through catalytic hydrolysis, offering a safer alternative to compressed hydrogen to fuel cells. However, the harsh thermal and chemical environments of concentrated NaBH4 hydrolysis cause rapid catalyst deactivation. Herein, we synthesized a high-entropy layered hydroxide nanocatalyst (HELH, FeCoNiCuZn@ZIF-67) via an in-situ etching-growth strategy with ZIF-67. The mechanical structure of residual ZIF-67 inside ensures the robustness of active centers and particles. The efficiency of hydrogen generation is guaranteed by the synergy of different metals in high-entropy structures, which involves borohydride adsorption and H2 release. Benefiting from this cooperative architecture, the HELH catalyst achieves a high hydrogen generation rate of 8 L min-1 g-1 in a 25 wt% NaBH4 solution. Density functional theory and electrochemical analyses reveal that abundant oxygen vacancies and multi-metal synergy optimize water activation and lower the reaction barrier. This work provides an effective strategy for designing robust high-entropy catalysts for extreme conditions.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"19 4","pages":"94908464-94908464"},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908464.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147896212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerium-doped zinc oxide anchored halloysite nanoclays as skin management system for photoprotection and radiative cooling 掺铈氧化锌锚定高岭土纳米粘土作为光防护和辐射冷却的皮肤管理系统

2区材料科学

Nano Research Pub Date : 2026-01-16 DOI: 10.26599/nr.2026.94908443

Xiangyu Chen, Yuwei Qiu, Shuiqing Zhou, Chuangchi Ma, Hong Li, Mingxian Liu

{"title":"Cerium-doped zinc oxide anchored halloysite nanoclays as skin management system for photoprotection and radiative cooling","authors":"Xiangyu Chen, Yuwei Qiu, Shuiqing Zhou, Chuangchi Ma, Hong Li, Mingxian Liu","doi":"10.26599/nr.2026.94908443","DOIUrl":"https://doi.org/10.26599/nr.2026.94908443","url":null,"abstract":"Sunscreens are crucial for skin health by protecting against the harmful effects of ultraviolet (UV) radiation. To overcome persistent limitations of irritation and discomfort in existing formulations, a high-performance radiative cooling sunscreen, CZHR, has been strategically designed. This formulation synergistically integrates cerium-doped zinc oxide (Ce-ZnO) and halloysite nanotubes (HNTs) to achieve dual UV protection and skin cooling. As a nanocarrier, HNTs effectively regulate the particle size, morphology, and oxygen vacancies of Ce-ZnO, significantly enhancing UV protection and catalytic activity. Resveratrol is further incorporated to improve UV resistance and pathogen inhibition. The resulting CZHR-based Pickering emulsion exhibits excellent UV shielding, high solar reflectance (0.73), and infrared emissivity (0.87). In vitro and vivo tests show efficacy in alleviating UV-induced cellular damage and inhibiting biofilm formation. Notably, compared to commercial products, the CZHR sunscreen reduces skin temperature by an additional 1.7-2.9oC. Biosafety evaluation confirms non-irritating property and negligible skin penetration. This thermal management system represents a promising platform for advanced photoprotection and radiative cooling.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"19 5","pages":"94908443-94908443"},"PeriodicalIF":0.0,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908443.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailoring pH-ultra-sensitive oncolytic polyesters via a manageable polymer blending strategy 通过可管理的聚合物混合策略定制ph超敏感溶瘤聚酯

2区材料科学

Nano Research Pub Date : 2026-01-16 DOI: 10.26599/nr.2026.94908441

Chanjuan Su, Yuxuan Zeng, Shihua Zhang, Yueling Yuan, Yuxuan Gong, Huosheng Zhou, Fuxiang Wang, Jihong Wang, Menghua Xiong, Yan Bao

{"title":"Tailoring pH-ultra-sensitive oncolytic polyesters via a manageable polymer blending strategy","authors":"Chanjuan Su, Yuxuan Zeng, Shihua Zhang, Yueling Yuan, Yuxuan Gong, Huosheng Zhou, Fuxiang Wang, Jihong Wang, Menghua Xiong, Yan Bao","doi":"10.26599/nr.2026.94908441","DOIUrl":"https://doi.org/10.26599/nr.2026.94908441","url":null,"abstract":"pH-Ultra-sensitive oncolytic polymers hold great promise for cancer therapy due to their selective oncolytic activity in the tumor microenvironment. However, achieving well-defined structures and finely tunable pH responsiveness for these polymers remains a challenge. Herein, we developed a straightforward blending strategy using two well-defined alternating polyesters with distinct pH sensitivities to create pH-ultra-sensitive hybrid polyester nanoparticles (Hps) with precisely engineered responsiveness. By varying the mass ratio of the two components, the pKa of the Hps could be continuously tuned from 6.37 to 7.01. The resulting Hps demonstrated a sharp pH-dependent membranolytic activity switch within a 0.3 pH unit window, with minimal cytotoxicity observed at pH values above the transition pH. A lead Hp formulation identified through screening exhibited potent cytotoxicity at pH 6.8, along with a favorable safety profile and significant antitumor efficacy in vivo. This blending strategy establishes a flexible and simple platform for customizing pH responsiveness of oncolytic polymers, advancing oncolytic therapy.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"19 3","pages":"94908441-94908441"},"PeriodicalIF":0.0,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NR.2026.94908441.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147922107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0