Advances in nanotechnology-enabled adjuvants for peptide-based cancer vaccines.

IF 9 2区 材料科学 Q1 CHEMISTRY, PHYSICAL
Nano Research Pub Date : 2025-07-01 Epub Date: 2025-05-22 DOI:10.26599/nr.2025.94907534
Mengwen Li, Wenpan Li, Zhi Li, Jianqin Lu
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引用次数: 0

Abstract

Peptide-based vaccines only contain peptide epitopes and exclude unnecessary biological materials, which greatly reduces the risk of causing an undesired immune response and further improves the safety profile, garnering considerable interest in vaccine development. However, the immunogenicity induced by these peptides alone is not potent enough to elicit an effective immune response. Recently, combining the adjuvants with peptide antigens has shown promising effects to realize a satisfying immune response. In this review, we discuss the development of immunoadjuvants to enhance the safety and efficacy of peptide-based vaccines. The emphasis is placed on the application and clinical translation of nanotechnology-based adjuvants, highlighting the associated challenges and exploring future directions.

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基于肽基癌症疫苗的纳米佐剂研究进展
基于肽的疫苗只含有肽表位,排除了不必要的生物材料,这大大降低了引起不期望的免疫反应的风险,并进一步提高了安全性,在疫苗开发中引起了相当大的兴趣。然而,仅由这些肽诱导的免疫原性不足以引起有效的免疫反应。近年来,佐剂与肽抗原的结合已显示出令人满意的免疫应答效果。在这篇综述中,我们讨论了免疫佐剂的发展,以提高肽基疫苗的安全性和有效性。重点放在纳米佐剂的应用和临床翻译上,强调相关的挑战和探索未来的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nano Research
Nano Research 化学-材料科学:综合
CiteScore
14.30
自引率
11.10%
发文量
2574
审稿时长
1.7 months
期刊介绍: Nano Research is a peer-reviewed, international and interdisciplinary research journal that focuses on all aspects of nanoscience and nanotechnology. It solicits submissions in various topical areas, from basic aspects of nanoscale materials to practical applications. The journal publishes articles on synthesis, characterization, and manipulation of nanomaterials; nanoscale physics, electrical transport, and quantum physics; scanning probe microscopy and spectroscopy; nanofluidics; nanosensors; nanoelectronics and molecular electronics; nano-optics, nano-optoelectronics, and nano-photonics; nanomagnetics; nanobiotechnology and nanomedicine; and nanoscale modeling and simulations. Nano Research offers readers a combination of authoritative and comprehensive Reviews, original cutting-edge research in Communication and Full Paper formats. The journal also prioritizes rapid review to ensure prompt publication.
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