Materials & Design最新文献

Micromechanical study of clay stabilized with nano-Al2O3 particles and reinforced by polypropylene short micro-fibers 纳米氧化铝稳定聚丙烯短纤维增强粘土的微观力学研究

IF 7.9 2区材料科学

Materials & Design Pub Date : 2025-10-21 DOI: 10.1016/j.matdes.2025.114982

Hadi Ahmadi , Mohammad Kazem Hassanzadeh-Aghdam , Maedeh Nasiri Pishvari

{"title":"Micromechanical study of clay stabilized with nano-Al2O3 particles and reinforced by polypropylene short micro-fibers","authors":"Hadi Ahmadi , Mohammad Kazem Hassanzadeh-Aghdam , Maedeh Nasiri Pishvari","doi":"10.1016/j.matdes.2025.114982","DOIUrl":"10.1016/j.matdes.2025.114982","url":null,"abstract":"<div><div>Understanding the geomechanical behavior of clayey soils is essential in geotechnical engineering. This study investigates the combined effects of nano-Al<sub>2</sub>O<sub>3</sub> particles and polypropylene (PP) short micro-fibers on clay through laboratory testing and micromechanical modeling. A hierarchical micromechanics-based model is proposed to predict the effective stiffness of nano-Al<sub>2</sub>O<sub>3</sub>/PP/clay ternary composites, explicitly incorporating microstructural parameters such as filler content, geometry, and interfacial bonding. The model accounts for the PP–clay interfacial region, nanoparticle dispersion, fiber waviness, and orientation. Clay samples were stabilized with 0–1 % nano-Al<sub>2</sub>O<sub>3</sub> and 0–1.2 % PP fibers by dry weight, and unconfined compression tests were conducted to determine unconfined compressive strength (UCS) and stiffness (E<sub>50</sub>). At 1.2 % PP fiber content, increasing nano-Al<sub>2</sub>O<sub>3</sub> improved UCS by up to 78 % and E<sub>50</sub> by up to 142 %. Likewise, PP fibers enhanced UCS by 76 % and E<sub>50</sub> by 57.5 %. SEM analysis revealed nanoparticle-induced particle interlocking and fiber-enhanced cohesion, while EDS confirmed the integration of Al and C elements into the soil matrix. Experimental results showed strong agreement with model predictions, validating the proposed approach. This micromechanical framework provides an effective predictive tool for optimizing fiber- and nano-modified clays, contributing to more efficient and sustainable soil stabilization practices.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"260 ","pages":"Article 114982"},"PeriodicalIF":7.9,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145340307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of low melting point alloy with high latent heat based on predictive models and standardized experiments 基于预测模型和标准化实验的低熔点高潜热合金研究

IF 7.9 2区材料科学

Materials & Design Pub Date : 2025-09-28 DOI: 10.1016/j.matdes.2025.114848

Tianrui Hou, Yuming Xing, Zixian Wang, Jianbao Yin

{"title":"Development of low melting point alloy with high latent heat based on predictive models and standardized experiments","authors":"Tianrui Hou, Yuming Xing, Zixian Wang, Jianbao Yin","doi":"10.1016/j.matdes.2025.114848","DOIUrl":"10.1016/j.matdes.2025.114848","url":null,"abstract":"<div><div>This study addresses discrepancies in existing literature by implementing standardized sample preparation procedures and characterization methods, thereby establishing the most comprehensive phase change point database for eutectic low-melting-point alloy (LMPA) to date. A machine learning-based (random forest) phase change point prediction model was developed, effectively overcoming the practical limitations of traditional activity coefficient-based approaches. Furthermore, a latent heat prediction model incorporating melting entropy, mixing entropy, and the solid–liquid heat capacity difference was proposed, demonstrating superior accuracy for quaternary and quinary systems. Guided by these models, two high-performance LMPA (HLHD65 and HLHD76) were designed: HLHD65 achieves 10.31 % and 10.54 % higher mass and volumetric latent heat density, respectively, than Indalloy 140, while HLHD76 demonstrates improvements of 20.13 % and 20.07 % over Wood’s metal. This work provides a robust foundation and establishes a paradigm for developing advanced thermal energy storage materials.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"259 ","pages":"Article 114848"},"PeriodicalIF":7.9,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HPV VLPs-based RNA-delivery system for synergistic BCL-2 silencing and mitochondrial apoptosis in NSCLC cells 基于HPV vlps的rna递送系统协同BCL-2沉默和非小细胞肺癌细胞线粒体凋亡

IF 7.9 2区材料科学

Materials & Design Pub Date : 2025-09-27 DOI: 10.1016/j.matdes.2025.114820

Meng-Fan Feng , Jinyu Zhu , Li-Miao Qin , Xianghui Yu , Haihong Zhang , Xiao-Xia Han , Yuqing Wu

{"title":"HPV VLPs-based RNA-delivery system for synergistic BCL-2 silencing and mitochondrial apoptosis in NSCLC cells","authors":"Meng-Fan Feng , Jinyu Zhu , Li-Miao Qin , Xianghui Yu , Haihong Zhang , Xiao-Xia Han , Yuqing Wu","doi":"10.1016/j.matdes.2025.114820","DOIUrl":"10.1016/j.matdes.2025.114820","url":null,"abstract":"<div><div>Non-small cell lung cancer (NSCLC) resists apoptosis and lacks targeted therapies. We developed a tetra-functional assembly, siRNA_D-pep@VLP-SP5-2, integrating BCL-2 siRNA and a cationic mitochondrial destabilization D-peptide within the SP5-2-modified HPV virus-like particle (VLP). This multifunctional assembly integrate: (1) SP5-2-driven tumor targeting precision, (2) VLP-improved cellular uptake, (3) siRNA-induced BCL-2 silencing (70 % knockdown), and (4) D-peptide-triggered <em>Cyt c</em> release and mitochondrial apoptosis. <em>In cells</em>, siRNA_D-pep@VLP-SP5-2 induced 91 % apoptosis of A549 cells, while in A549 tumor-bearing mice, it reduced 78.2 % tumor growth without systemic toxicity. This multifunctional assembly pioneer’s co-delivery of gene and therapeutical peptide synergistically, overcoming key barriers in NSCLC precision therapy. In particular, the thoroughly revealed apoptotic kinetics for the RNAi therapeutics and peptide-mediated cytotoxicity, together with the modular design using VLP opens new avenues for multimodal cancer therapeutics, expecting to transition from “limit-target inhibition” toward “dynamic network-level regulation”, thereby establishing a paradigm-shifting framework for solid tumor treatment.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"259 ","pages":"Article 114820"},"PeriodicalIF":7.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microscopic characterization of the anisotropic mechanical behavior of human linea alba and anterior rectus sheath: contributions of collagen and elastin 人体白线和前直肌鞘各向异性力学行为的显微表征：胶原蛋白和弹性蛋白的贡献

IF 7.9 2区材料科学

Materials & Design Pub Date : 2025-09-27 DOI: 10.1016/j.matdes.2025.114853

Laure Astruc , Frédéric Turquier , Mathias Brieu , Thierry Hoc

{"title":"Microscopic characterization of the anisotropic mechanical behavior of human linea alba and anterior rectus sheath: contributions of collagen and elastin","authors":"Laure Astruc , Frédéric Turquier , Mathias Brieu , Thierry Hoc","doi":"10.1016/j.matdes.2025.114853","DOIUrl":"10.1016/j.matdes.2025.114853","url":null,"abstract":"<div><div>Abdominal wall tissues, including the linea alba (LA) and anterior rectus sheath (ARS), exhibit pronounced structural and mechanical heterogeneity that critically influences function and surgical outcomes. Current hernia repair meshes often fail to replicate this complexity, highlighting the need for a mechanistic understanding linking microarchitecture to tissue mechanics. This study combines uniaxial tensile testing with two-photon confocal microscopy to quantify collagen fiber orientation and elastin distribution in ARS and LA samples from eight human donors. Mechanical testing in longitudinal and transverse directions revealed pronounced anisotropy in ARS, with collagen alignment strongly predicting tissue stiffness (R<sup>2</sup> = 0.79–0.88) and explaining inter- and intra-individual mechanical variability. LA displayed a layered collagen network with higher elastin content, consistent with its role in strain accommodation. By directly correlating microstructural organization with mechanical performance, this work uncovers key design principles for bioinspired implants: anisotropic collagen fiber orientation and elastin distribution must be considered to replicate native tissue mechanics. Specifically, the findings demonstrate that replicating the anisotropic collagen–elastin architecture is essential for achieving biomechanical compatibility in surgical meshes. This study provides a novel framework for engineering heterogeneous materials that faithfully reproduce native tissue mechanics, bridging fundamental biomechanics and translational biomaterials design.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"259 ","pages":"Article 114853"},"PeriodicalIF":7.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and mechanism research of online control and monitoring system for laser welding quality 激光焊接质量在线控制与监测系统的设计与机理研究

IF 7.9 2区材料科学

Materials & Design Pub Date : 2025-09-27 DOI: 10.1016/j.matdes.2025.114849

Qianqian Song , Miao He , Tengfei Li , Jinghua Han , Changtao He , Xiaoshuai Guo , Guoying Feng , Lingling Xiong

{"title":"Design and mechanism research of online control and monitoring system for laser welding quality","authors":"Qianqian Song , Miao He , Tengfei Li , Jinghua Han , Changtao He , Xiaoshuai Guo , Guoying Feng , Lingling Xiong","doi":"10.1016/j.matdes.2025.114849","DOIUrl":"10.1016/j.matdes.2025.114849","url":null,"abstract":"<div><div>The utilization of appropriate protective gas is essential for achieving superior quality in the laser welding of titanium alloys. This research focuses on optimizing the protective environment of the welding zone by varying the precharge duration of the protective gas. A systematic investigation was conducted to assess the impact of these adjustments on the quality of weld formation. By employing a combination of multi-scale characterization techniques, including macro-morphological analysis of the weld, plasma spectroscopy assessments, and microstructural evaluations, the fundamental physical phenomena occurring during the welding process and the patterns of weld quality evolution were elucidated. Additionally, a real-time monitoring approach utilizing plasma spectroscopy diagnostics was developed. This method allows for the reverse inference of the welding process state through the interpretation of plasma spectral characteristics, thereby establishing connections with the oxidation behavior of titanium alloys and facilitating a comprehensive analysis of the factors contributing to disturbances in the molten pool fluid dynamics. Furthermore, a numerical model grounded in thermodynamic principles was created to simulate the dynamic evolution of the molten pool, offering a quantitative explanation of the mechanisms by which the state of the protective gas influences the fluid behavior and thermal stability of the molten pool.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"259 ","pages":"Article 114849"},"PeriodicalIF":7.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-plane bidirectional quasi-static compression behavior of a novel multi-step star-isosceles triangular honeycomb 一种新型多阶星形等腰三角形蜂窝的平面内双向准静态压缩行为

IF 7.9 2区材料科学

Materials & Design Pub Date : 2025-09-27 DOI: 10.1016/j.matdes.2025.114836

Qipeng Zhang , Jie Jia , Lin Dong , Guoliang Zhi

{"title":"In-plane bidirectional quasi-static compression behavior of a novel multi-step star-isosceles triangular honeycomb","authors":"Qipeng Zhang , Jie Jia , Lin Dong , Guoliang Zhi","doi":"10.1016/j.matdes.2025.114836","DOIUrl":"10.1016/j.matdes.2025.114836","url":null,"abstract":"<div><div>Multi-stage plateau stress structures have recently attracted increasing attention for impact protection and energy absorption. However, most existing designs either provide limited in-plane energy absorption or exhibit multi-stage features only in one loading direction. To address the above-mentioned limitations, this research proposes a novel star-isosceles triangular honeycomb (SITH) structure. It combines the tunability of star-shaped geometries with the stability of triangular frameworks. The mechanical performance of SITH was systematically investigated through quasi-static experiments and numerical simulations. The results show that SITH provides excellent energy absorption in both directions under in-plane biaxial loading. Uniquely, it achieves three plateau stages in the Y direction. A theoretical model was formulated based on the deformation mechanisms that were observed. This model accurately predicts plateau stresses and critical strains. Parametric analyses of the key geometric angles further reveal their influence on the mechanical response. These insights support the optimization of structural performance. Compared with previously reported hybrid honeycombs, the proposed SITH structure demonstrates superior stability, tunable multi-stage energy absorption, and effectiveness in both loading directions. This work establishes a theoretical basis for design of star-shaped hybrid honeycombs. It also offers a promising strategy for impact protection in complex engineering environments.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"259 ","pages":"Article 114836"},"PeriodicalIF":7.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selection of key alloying elements for improving the elastic modulus of titanium alloys based on feature screening methods 基于特征筛选法提高钛合金弹性模量的关键合金元素选择

IF 7.9 2区材料科学

Materials & Design Pub Date : 2025-09-27 DOI: 10.1016/j.matdes.2025.114844

Qingguo Huang , Dejun Song , Yameng Liu , Xinming Feng , Huadong Fu , Zhihao Zhang

{"title":"Selection of key alloying elements for improving the elastic modulus of titanium alloys based on feature screening methods","authors":"Qingguo Huang , Dejun Song , Yameng Liu , Xinming Feng , Huadong Fu , Zhihao Zhang","doi":"10.1016/j.matdes.2025.114844","DOIUrl":"10.1016/j.matdes.2025.114844","url":null,"abstract":"<div><div>Under the background of modern industrial lightweighting and high performance, the low elastic modulus of titanium alloys has become a key issue restricting their structural efficiency and load-bearing capacity. This study conducted feature screening on a small sample dataset, identifying the mean of atomic energy of the ground state (Fm1), the mean of a-lattice constant (Fm29), the mean of nuclear charge number (Fm40), and the variance of melting enthalpy (Fv43) as the four key features affecting the elastic modulus. The prediction accuracy R<sup>2</sup> of the best model reached 0.96, and a mathematical expression linking the modulus to these four key alloy factors was established using symbolic regression algorithms, achieving a direct correlation between input and target performance. Experimental verification revealed that, in addition to B and Si enhancing the modulus of titanium alloys, the element Ga can also significantly improve the modulus of titanium alloys. Alloys with elastic modulus exceeding 135 GPa were successfully prepared, achieving an increase of over 25 % in elastic modulus compared to TC4 alloy. Further research indicates that the high modulus properties of titanium alloys are primarily attributed to the precipitation of high-modulus second phases α<sub>2</sub>, TiB, and Ti<sub>5</sub>Si<sub>3</sub> in the microstructure.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"259 ","pages":"Article 114844"},"PeriodicalIF":7.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constructing multi-level heterogeneous structures in multi-principal element alloys for superior cryogenic tensile properties 在多主元素合金中构建多层非均相结构以获得优异的低温拉伸性能

IF 7.9 2区材料科学

Materials & Design Pub Date : 2025-09-27 DOI: 10.1016/j.matdes.2025.114845

Luke Xu , Yan Ma , Guohao Qin , Ping Jiang , Xiaolei Wu , Fuping Yuan

{"title":"Constructing multi-level heterogeneous structures in multi-principal element alloys for superior cryogenic tensile properties","authors":"Luke Xu , Yan Ma , Guohao Qin , Ping Jiang , Xiaolei Wu , Fuping Yuan","doi":"10.1016/j.matdes.2025.114845","DOIUrl":"10.1016/j.matdes.2025.114845","url":null,"abstract":"<div><div>The multi-level heterogeneous structures, consisting of heterogeneous grain structure, B2 nanoprecipitates, and chemical short-range ordering (CSROs), were designed and fabricated in the (CoNiV)<sub>95</sub>Al<sub>5</sub> multi-principal element alloy. The material exhibits superior tensile properties at 298 K, with simultaneous enhancement of yield strength and uniform elongation at 77 K. Specifically, it achieves ∼1.65 GPa yield strength and ∼19 % uniform elongation at room temperature, improving to ∼2.0 GPa and 22 % under cryogenic conditions (77 K). Under identical tensile strain, the average density of geometrically necessary dislocations (GNDs) increases more significantly at 77 K than at 298 K, enhancing hetero-deformation-induced hardening and improving tensile ductility. Uniformly dispersed nano-scale B2 nanoprecipitates provide strong precipitation hardening, while dense chemical short-range ordering (CSRO) imparts precipitation-like hardening through dislocation pinning. The strengthening at each level and the synergistic hardening effects among different levels are responsible for the excellent tensile properties in the multi-level heterogeneous structures, especially at 77 K.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"259 ","pages":"Article 114845"},"PeriodicalIF":7.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial NIR responsive targeted nanocomposite hydrogels loaded with Taxifolin for bone repair 含紫杉醇的抗菌近红外靶向纳米复合水凝胶用于骨修复

IF 7.9 2区材料科学

Materials & Design Pub Date : 2025-09-26 DOI: 10.1016/j.matdes.2025.114840

Hewei Wei , Feifei Feng , Qiteng Ding , Junran Yang , Taojing Yu , Xiaoyu Wu , Xiaohang Sun , Chuanbo Ding , Yupeng Song

{"title":"Antibacterial NIR responsive targeted nanocomposite hydrogels loaded with Taxifolin for bone repair","authors":"Hewei Wei , Feifei Feng , Qiteng Ding , Junran Yang , Taojing Yu , Xiaoyu Wu , Xiaohang Sun , Chuanbo Ding , Yupeng Song","doi":"10.1016/j.matdes.2025.114840","DOIUrl":"10.1016/j.matdes.2025.114840","url":null,"abstract":"<div><div>Bone defects have long posed a challenge in trauma orthopedics. Despite advancements in bone tissue engineering, there remains a bottleneck in developing bone implants that are less toxic, more effective, and reduce the need for secondary surgeries. To address this, we devised a light-responsive bone-targeted smart nano-delivery system. This system integrates polydopamine (PDA)-coated TAX-loaded ZIF-8 nanoparticles into a hydrogel with strong bioadhesion and biocompatibility (TAX@ZIF-8@PDA/ODEX-HD, TZPG). When exposed to near-infrared light, TZPG + NIR demonstrated a high photothermal conversion efficiency of 51.79 %. It exhibited a 99 % inhibition rate against Staphylococcus aureus, while also enhancing the proliferation and differentiation of osteoblasts (MC3T3-E1), thereby accelerating bone defect repair in a rat cranial bone defect model. Additionally, TZPG + NIR accelerates bone tissue repair by upregulating osteogenic-related proteins (ALP, RUNX2, OSX, OCN) while enhancing the expression of COL-I and PDGFA proteins to promote angiogenesis. Overall, TZPG + NIR created an antimicrobial microenvironment <em>in vitro</em>, enabled intelligent controlled release, and programmed degradation during the bone repair cycle, achieving a one-time therapeutic effect. This study highlights the promising applications of near-infrared light-responsive material TZPG in regenerative medicine, offering a novel approach to developing multifunctional bone scaffolds for repairing bone defects as a viable alternative to autografts.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"259 ","pages":"Article 114840"},"PeriodicalIF":7.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smart near-infrared manganese-doped carbon dot-microneedle assemblies for tumor microenvironment-activated photodynamic-chemodynamic combined therapy 智能近红外锰掺杂碳点微针组件用于肿瘤微环境激活光动力-化学动力联合治疗

IF 7.9 2区材料科学

Materials & Design Pub Date : 2025-09-26 DOI: 10.1016/j.matdes.2025.114833

Xiaofang Lv , Yongzhi Xu , Yuanping Hao , Beibei Cong , Yingjie Xu , Meihua Gao , Wanchun Wang

{"title":"Smart near-infrared manganese-doped carbon dot-microneedle assemblies for tumor microenvironment-activated photodynamic-chemodynamic combined therapy","authors":"Xiaofang Lv , Yongzhi Xu , Yuanping Hao , Beibei Cong , Yingjie Xu , Meihua Gao , Wanchun Wang","doi":"10.1016/j.matdes.2025.114833","DOIUrl":"10.1016/j.matdes.2025.114833","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) that utilizes photosensitizers to induce reactive oxygen species (ROS) generation has become an important option in cancer clinical treatment due to its spatiotemporal controllability and non-invasive treatment characteristics. However, the inherent characteristics of the tumor microenvironment limit oxidative stress. In addition, traditional photosensitizers have problems such as poor water solubility, poor photostability and complex synthesis, which hinder the clinical application efficacy of PDT. To further enhance the efficacy of PDT, this study constructed a manganese-doped carbon dots (Mn-CDs) nanosystem with a dual-functional synergistic mechanism. It can catalyze endogenous H<sub>2</sub>O<sub>2</sub> to undergo a Fenton-like reaction in response to the weakly acidic microenvironment of tumors, continuously generating <sup><img></sup>OH. Under laser irradiation, it can accelerate the Fenton like reaction to produce <sup>1</sup>O<sub>2</sub> (quantum yield of 0.39), deplete glutathione (GSH) to disrupt the intracellular redox balance, and the apoptosis rate can reach 86.14 %. The tumor-bearing mouse model showed that the tumor growth inhibition rate could reach 95.5 %. Notably, the treatment dose was precisely delivered through hyaluronic acid dissolved microneedles for transdermal delivery, ensuring a local effective drug concentration while reducing systemic toxicity, providing a new solution that is both highly efficient and safe for targeted treatment of oral squamous cell carcinoma.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"259 ","pages":"Article 114833"},"PeriodicalIF":7.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0