Materials & Design最新文献

{"title":"Biodistribution and transport of intratympanically administered drugs in the inner ear using a porcine ex-vivo chamber model.","authors":"Farimah Moazzam, Samuel Holdsclaw, Fengyi Yu, Rachel Maria Titus, Adele Moatti, Alon Greenbaum","doi":"10.1016/j.matdes.2026.116529","DOIUrl":"10.1016/j.matdes.2026.116529","url":null,"abstract":"<p><p>Effective pharmacotherapy for hearing loss remains a significant challenge because of the blood-labyrinth barrier, which limits systemic drug access and often necessitates local intratympanic (IT) administration. However, the distribution of drugs after IT injection between the vestibular system and cochlea is unclear. Although the round window membrane is the main recognized entry route, in this study, we explored alternative pathways, namely the oval window (OW) and the thin apical otic capsule, using an ex vivo porcine model to assess their permeability to different solvent vehicles. We demonstrated that the route of entry is critically on the solvent composition and additives; in particular, reconstituting dexamethasone-fluorescein in dimethyl sulfoxide enhanced permeability through the OW by 42-fold compared to that with methanol, establishing the OW as a pathway for this solvent type rather than the RWM. Furthermore, we identified the thin apical otic capsule as a third drug-entry route in young pigs. Surgical sealing of this pathway in vivo, which reduces perilymph drug levels, underscores its importance in human translational studies. In summary, we developed a robust ex vivo multi-barrier model integrated with FluidSim to predict the inner ear drug biodistribution.</p>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"268 ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover_268","authors":"","doi":"10.1016/j.matdes.2026.116646","DOIUrl":"10.1016/j.matdes.2026.116646","url":null,"abstract":"","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"268 ","pages":"Article 116646"},"PeriodicalIF":8.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148642409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclic temperature-dependent response of unit cell auxetic structures in an additively manufactured shape memory alloy.","authors":"Emanuele Avoledo, Xiebin Wang, Jiawen Xu, Federico Scalzo, Enrico Salvati","doi":"10.1016/j.matdes.2026.116578","DOIUrl":"10.1016/j.matdes.2026.116578","url":null,"abstract":"<p><p>This study investigates the mechanical response of additively manufactured NiTi sinusoidal hexagonal re-entrant auxetic structures, focusing on the combined influence of temperature and local geometry. The NiTi alloy fabricated by laser powder bed fusion (L-PBF) was thermomechanically characterised to identify conditions promoting enhanced superelastic response, while X-ray micro-computed tomography was used to assess internal porosity. Monotonic and strain-controlled cyclic tensile tests were performed on auxetic cells with three different fillet radii, using a dedicated setup combining digital image correlation and closed-loop temperature control. The results reveal a clear separation between material- and geometry-driven effects. Temperature primarily governs the load levels through the superelastic response of the alloy, whereas auxetic deformation behaviour and failure mechanisms are mainly controlled by the structural geometry, particularly the fillet radius. Increasing the fillet radius significantly affects the deformation and failure response of the auxetic structures, altering the relationship between failure strain and absolute displacement through the corresponding change in cell geometry. The experimentally measured Poisson's ratio was compared with predictions from analytical models. Although these overestimate the auxetic response, they provide a reasonable first-order estimate. These findings provide insight into the design of additively manufactured NiTi auxetic architectures.</p>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"268 ","pages":"None"},"PeriodicalIF":8.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover_267","authors":"","doi":"10.1016/j.matdes.2026.116457","DOIUrl":"10.1016/j.matdes.2026.116457","url":null,"abstract":"","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"267 ","pages":"Article 116457"},"PeriodicalIF":8.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148500015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the mechanisms for high-temperature mechanical properties of a high-manganese austenitic steel at 500 °C","authors":"Yuxin Dai,&nbsp;Manchao He,&nbsp;Wendal Victor Yue,&nbsp;Eryu Wang,&nbsp;Xiaojie Yang","doi":"10.1016/j.matdes.2026.116389","DOIUrl":"10.1016/j.matdes.2026.116389","url":null,"abstract":"<div><div>Conventional construction steel suffers severe softening at 500 ℃ under short-term fire exposure (the decrease of ultimate strength on reduction of 50 %, less than 500 MPa), while traditional austenitic steel exhibits drastically elevated stacking fault energy (SFE) at high temperature, which restricts Shockley partial dislocation dissociation and twinning, resulting in deterioration of high-temperature mechanical properties. This study compared high-manganese austenitic steel (HAMS) tensile properties at 500 ℃ with and without prior 10 h thermal exposure. High-temperature tensile tests conducted at 500 ℃ demonstrate that 10 h thermal exposure creates favorable thermodynamic conditions for (Fe,Mn)₃AlC precipitation which reduced 40  mJ·m⁻² SFE and facilitating the dissociation of Shockley 1/6 &lt; 112 &gt; partial dislocations. Moreover, the thermal exposure creates microstructural evolution is characterized by an increment in low-angle grain boundaries (LAGBs) from 61.9%±1.9% to 69.9%±2.2%, a fragmented distribution of Schmid factors. The synergy between Lomer-Cottrell (L-C) locks and twins optimizes the properties of HAMS at 500 ℃, it achieves a yield strength (YS) of 416 MPa and ultimate tensile strength (UTS) of 532 ± 1.5 MPa (a reduction of 39%, surpassing the unexposed state 487 ± 2.0 MPa,), with ductility only decreasing by 5.3% (from 36.0%±0.6% to 34.1%±0.4%).</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"267 ","pages":"Article 116389"},"PeriodicalIF":8.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148500013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover_266","authors":"","doi":"10.1016/j.matdes.2026.116289","DOIUrl":"10.1016/j.matdes.2026.116289","url":null,"abstract":"","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"266 ","pages":"Article 116289"},"PeriodicalIF":7.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148185604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-modal strategy for enhancing titanium-bone interface strength and antimicrobial properties of PMMA bone cements.","authors":"Samuel Weber, Steven H Lewis, Fernanda Sandes de Lucena, Henrico B Strazzi-Sahyon, Fernanda M Tsuzuki, Sivashankari P Rajasekaran, Matthew G Logan, Ana Paula P Fugolin, Karina H Nakayama, Carmem S Pfeifer","doi":"10.1016/j.matdes.2026.115970","DOIUrl":"10.1016/j.matdes.2026.115970","url":null,"abstract":"<p><p>Infection prevention and retention at the bone-device interface are critical for long-term stability of titanium-based biomedical implants. This study utilized a multifactorial approach to assess bond strength and antibacterial activity of polymethyl methacrylate (PMMA) bone cements modified with polymerizable antimicrobials (quaternary ammonium methacrylate, QAM) for sustained antibiofilm effects. Four commercial dental adhesives (Gen 4, Gen 5, Gen 6, Gen 7) were tested between porcine cortical bone and PMMA bone cements (Jet Acrylic or Biomet Bone Cement R). Shear bond strength (SBS), interface analysis (SEM, FTIR/ATR) and cytotoxicity (MTT) were evaluated and compared to controls without dental adhesive, which is the current standard of care. Top performing materials were subjected to stringent mechanical cycling in a bioreactor, followed by SBS assessment. Finally, bone cements were modified with QAMs and evaluated with or without dental adhesive for physical properties, antibiotic activity and SBS. Refobacin was used as an antibiotic-containing commercial control. Results showed more than a twenty-fold increase in SBS after 24 h and up to a fifteen-fold improvement after mechanical cycling with the Gen 6 adhesive, compared to commercial control cements. Refobacin and the QAM-modified cement significantly reduced <i>S. aureus</i> biofilm biomass, but the QAM cements were significantly better able to maintain antimicrobial activity after water storage. Even though the shear bond strength was reduced with either QAM or Refobacin, the presence of the adhesive mitigated this reduction in comparison with the Refobacin applied without the adhesive. Overall, the results suggest that the application of dental adhesives prior to cementation provides an avenue for improving implant retention and that incorporating QAMs may offer a means of sustained infection control.</p>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"265 ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148215722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover_265","authors":"","doi":"10.1016/j.matdes.2026.116132","DOIUrl":"10.1016/j.matdes.2026.116132","url":null,"abstract":"","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"265 ","pages":"Article 116132"},"PeriodicalIF":7.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147858621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-responsive organic materials: Bioengineered design, biomedical functions, and translational potential in tumor therapy","authors":"Jiali Sun ,&nbsp;Haochen Yao ,&nbsp;Guoqing Wang","doi":"10.1016/j.matdes.2026.115867","DOIUrl":"10.1016/j.matdes.2026.115867","url":null,"abstract":"<div><div>Ultrasound (US)-mediated tumor therapy has emerged as a promising non-invasive biomedical strategy characterized by deep tissue penetration, spatiotemporal precision, and excellent biocompatibility. US-responsive organic materials, including small-molecule sonosensitizers, biopolymer-based materials and metal/covalent organic frameworks (MOFs/COFs), serve as core platforms for precision oncology due to their tunable biofunctions, inherent biocompatibility, and versatile engineering potential, enabling amplified thermal effects, targeted cavitation, and augmented sonodynamic therapy (SDT). This review systematically summarizes their bioengineered design principles (e.g., biocompatible functional group modification, biodegradable nanostructure assembly, bioactive hybrid construction) to regulate US responsiveness and enhance biosafety, as well as their applications in targeted drug delivery, synergistic combination therapy (such as chemo-sonodynamic and immunotherapy synergy), and tumor microenvironment modulation, with a focus on in vivo biocompatibility and translational progress including preclinical validation and ongoing clinical trials. Furthermore, it addresses key clinical translation challenges and future design directions, providing valuable insights for developing next-generation materials to achieve precise, safe tumor therapy aligned with minimally invasive oncology demands.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"265 ","pages":"Article 115867"},"PeriodicalIF":7.9,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147550001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-functional Ti coating with spatiotemporal antibacterial activity and osteoimmune modulation for implant-related infection","authors":"Ziyi Zhao ,&nbsp;Qimin Hong ,&nbsp;Zhen Liu ,&nbsp;Ziyang Tian ,&nbsp;Wei Zhang ,&nbsp;Rui Wang ,&nbsp;Shuo Geng ,&nbsp;Jianping Yang ,&nbsp;Bin’en Nie ,&nbsp;Bing Yue","doi":"10.1016/j.matdes.2026.115558","DOIUrl":"10.1016/j.matdes.2026.115558","url":null,"abstract":"<div><div>Stimulating bone regeneration post-orthopedic implantation while inhibiting infections, particularly those caused by multidrug-resistant <em>Staphylococcus aureus</em>, remains a major clinical challenge in orthopedic surgery. Enhancing antibacterial performance while preserving bone integration remains challenging, as these two functions are often difficult to optimize simultaneously using conventional strategies. To this end, we developed a multifunctional Ti surface coating comprising Cu(I) oxide (Cu₂O) nanoparticles and E7-KR12 peptide. Characterization and in vitro and in vivo assay results revealed that this multifunctional coating exhibited on-demand spatiotemporal antibacterial action and osteoimmune modulation: Cu₂O provided early-stage bactericidal activity and promoted M1-type macrophage polarization, enhancing immune-mediated bacterial clearance, while E7-KR12 was comprised of an antimicrobial peptide (KR12) and a bone marrow mesenchymal stem cell adhesion-promoting peptide (E7). During the healing phase, the E7-KR12 coating promoted rat bone marrow-derived mesenchymal stem cells (rBMSC) recruitment, macrophage M2 polarization, and osteogenic differentiation. In vitro studies confirmed strong antibacterial activity, favorable immunomodulation, and enhanced osteogenesis. In an implant-related infection model, the multifunctional Ti coating reduced the bacterial burden, suppressed inflammation, and promoted robust bone regeneration. Therefore, this study formulated a novel Ti coating with on-demand spatiotemporal antibacterial action and osteoimmune modulation, demonstrating translational potential for orthopedic implants in infection-prone environments.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"263 ","pages":"Article 115558"},"PeriodicalIF":7.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}