Materials & Design最新文献

Injectable hydrogel for controlled anlotinib delivery and enhanced anti-tumor therapy in non-small cell lung cancer 注射水凝胶用于控制anlotinib递送和增强非小细胞肺癌的抗肿瘤治疗

IF 7.6 2区材料科学

Materials & Design Pub Date : 2025-05-14 DOI: 10.1016/j.matdes.2025.114103

Hongwei Lan , Yuming Zhang , Zuoxiang Dong , Xiaochun Zhang

{"title":"Injectable hydrogel for controlled anlotinib delivery and enhanced anti-tumor therapy in non-small cell lung cancer","authors":"Hongwei Lan , Yuming Zhang , Zuoxiang Dong , Xiaochun Zhang","doi":"10.1016/j.matdes.2025.114103","DOIUrl":"10.1016/j.matdes.2025.114103","url":null,"abstract":"<div><div>Non-small cell lung cancer (NSCLC) is one of the most frequently targeted cancers in precision therapy. However, maintaining high drug concentrations within the tumor microenvironment (TME) remains challenging with traditional drug delivery methods, often resulting in increased systemic toxicity and drug resistance. To address these issues, we developed a multifunctional hydrogel—OSA-TA-CMCS-anlotinib (OSTCA)—by combining oxidized sodium alginate (OSA), carboxymethyl chitosan (CMCS), tannic acid (TA), and anlotinib for controlled local drug release. The hydrogel exhibited excellent self-healing ability, injectability, and mechanical properties. Significant inhibition of NSCLC cell proliferation, migration, and invasion was observed in vitro. In vivo studies further demonstrated that the OSTCA hydrogel resulted in superior antitumor and anti-angiogenic effects compared to anlotinib monotherapy. Additionally, the hydrogel achieved sustained, localized release of anlotinib within the TME, thereby enhancing therapeutic efficacy and reducing systemic toxicity. The OSTCA hydrogel offers a promising and effective strategy for the local treatment of NSCLC, potentially overcoming the limitations of traditional systemic administration methods and providing new insights for future clinical applications.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"254 ","pages":"Article 114103"},"PeriodicalIF":7.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of biodegradable benzobisthiazole-based conjugated polymers with pendant β-cyclodextrin for synergistic mild-temperature chemo-photothermal therapy 含β-环糊精的可生物降解苯并双噻唑基共轭聚合物的构建及其在温和化学光热协同治疗中的应用

IF 7.6 2区材料科学

Materials & Design Pub Date : 2025-05-14 DOI: 10.1016/j.matdes.2025.114102

Qi Lai , Shaorong Huang , Yu Wu , Bei Hu , Shuilin Chen , Kun Zhang , Yuqin Xu , Xiaoyong Zhang , Guicai Sun , Yulong Ouyang

{"title":"Construction of biodegradable benzobisthiazole-based conjugated polymers with pendant β-cyclodextrin for synergistic mild-temperature chemo-photothermal therapy","authors":"Qi Lai , Shaorong Huang , Yu Wu , Bei Hu , Shuilin Chen , Kun Zhang , Yuqin Xu , Xiaoyong Zhang , Guicai Sun , Yulong Ouyang","doi":"10.1016/j.matdes.2025.114102","DOIUrl":"10.1016/j.matdes.2025.114102","url":null,"abstract":"<div><div>Photothermal therapy has rapidly gained attention as a promising strategy for tumor treatment, owing to its noninvasive nature, ease of operation, high spatial precision, and minimal risk of developing drug resistance. Despite its advantages, the simple and efficient synthesis of photothermal agents (PTAs) that simultaneously exhibit high photothermal conversion efficiency, excellent water dispersibility, low toxicity, biodegradability, and strong therapeutic performance remains a significant challenge. In this study, we successfully synthesized a benzobisthiazole-based conjugated polymer (DPD-CAN-OH) bearing pendant β-cyclodextrin groups via a click condensation reaction. Doxorubicin was subsequently loaded onto DPD-CAN-OH through the formation of a host–guest inclusion complex, resulting in the DPD-CAN-OH-DOX formulation. Characterization results demonstrated that both DPD-CAN-OH and DPD-CAN-OH-DOX exhibit small particle sizes, high water dispersibility, excellent photothermal conversion efficiency, and favorable biodegradability. Biological assays further confirmed that DPD-CAN-OH is associated with low cytotoxicity and good biocompatibility. Notably, DPD-CAN-OH showed significant potential for osteosarcoma treatment by enhancing reactive oxygen species generation and inducing apoptosis in cancer cells. Importantly, the DPD-CAN-OH-DOX complex exhibited markedly superior antitumor efficacy compared to treatment with doxorubicin or DPD-CAN-OH alone, highlighting the therapeutic benefits of combining chemotherapy with photothermal therapy. Considering the straightforward and efficient synthesis process, along with the excellent physicochemical and biological characteristics of the PTAs developed, we believe this work provides valuable new insights into the design and fabrication of multifunctional PTAs for effective cancer therapy.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"254 ","pages":"Article 114102"},"PeriodicalIF":7.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theoretical study in dual-channel quasi bound-states in the continuum in YaBa2Cu3O7 ceramic split-ring resonator metasurface and multi-functional responsive sensing YaBa2Cu3O7陶瓷劈环谐振腔中连续介质双通道准束缚态的理论研究

IF 7.6 2区材料科学

Materials & Design Pub Date : 2025-05-14 DOI: 10.1016/j.matdes.2025.114098

Ting-Hao Zhang , Bao-Fei Wan , Rui-Yang Dong , Bing-Xiang Li , Hai-Feng Zhang

{"title":"Theoretical study in dual-channel quasi bound-states in the continuum in YaBa2Cu3O7 ceramic split-ring resonator metasurface and multi-functional responsive sensing","authors":"Ting-Hao Zhang , Bao-Fei Wan , Rui-Yang Dong , Bing-Xiang Li , Hai-Feng Zhang","doi":"10.1016/j.matdes.2025.114098","DOIUrl":"10.1016/j.matdes.2025.114098","url":null,"abstract":"<div><div>In recent years, quasi-bound-states in the continuum (q-BIC) have been widely studied, and mechanisms for exciting q-BIC have been continuously proposed. In the research of q-BIC, symmetric-protecting q-BIC is an important branch, and as a classic metasurface design scheme, a split-resonant ring (SRR) has been found to excite q-BIC. A dual-channel q-BIC design is proposed based on the symmetry-breaking property of YaBa<sub>2</sub>Cu<sub>3</sub>O<sub>7</sub> ceramic SRR metasurface. Two asymmetry parameters are introduced into YaBa<sub>2</sub>Cu<sub>3</sub>O<sub>7</sub> ceramic SRR metasurface, which can excite q-BIC channels at two frequency positions, respectively. This characteristic is utilized to analyze sample thickness and detect refractive index separately at two q-BIC channels. The q-BIC channel 1 is used as a responsive thickness sensor to detect the thickness of the sample layer. The q-BIC channel 2 realizes the function of refractive index detection. Herein, a method is provided for exciting dual-channel q-BIC and utilizing the high quality factor of q-BIC to achieve multi-functional sensing. It has enormous potential value in biomedical and environmental monitoring fields.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"254 ","pages":"Article 114098"},"PeriodicalIF":7.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Segregation to grain boundaries in disordered systems: An application to a Ni-based multi-component alloy 无序体系中晶界偏析：在镍基多组分合金中的应用

IF 7.6 2区材料科学

Materials & Design Pub Date : 2025-05-13 DOI: 10.1016/j.matdes.2025.114074

Dominik Gehringer, Lorenz Romaner, David Holec

{"title":"Segregation to grain boundaries in disordered systems: An application to a Ni-based multi-component alloy","authors":"Dominik Gehringer, Lorenz Romaner, David Holec","doi":"10.1016/j.matdes.2025.114074","DOIUrl":"10.1016/j.matdes.2025.114074","url":null,"abstract":"<div><div>Segregation to defects, in particular to grain boundaries (GBs), is an unavoidable phenomenon leading to changed material behavior over time. With the increase of available computational power, unbiased quantum-mechanical predictions of segregation energies, which feed classical thermodynamics models of segregation (e.g., McLean isotherm), become available. In recent years, huge progress towards predictions closely resembling experimental observations was made by considering the statistical nature of the segregation process due to competing segregation sites at a single GB and/or many different types of co-existing GBs. In the present work, we further expand this field by explicitly showing how compositional disorder, present in real engineering alloys (e.g., steels or Ni-based superalloys), gives rise to a spectrum of segregation energies. With the example of a Σ5 GB in a Ni-based model alloy (Ni-Co-Cr-Ti-Al), we show that the segregation energies of Fe, Mn, W, Nb, and Zr are significantly different from those predicted for pure elemental Ni. We further use the predicted segregation energy spectra in a statistical evaluation of GB enrichment, which allows for extracting segregation enthalpy and segregation entropy terms related to the chemical complexity in multi-component alloys.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"254 ","pages":"Article 114074"},"PeriodicalIF":7.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Size-dependent radiative cooling power of glass-polymer metafilms 玻璃聚合物元膜的尺寸依赖性辐射冷却能力

IF 7.6 2区材料科学

Materials & Design Pub Date : 2025-05-13 DOI: 10.1016/j.matdes.2025.114095

Wenhui Xie , Zhenyu Fan , Gang Tan , Ronggui Yang , Yujie Wei

{"title":"Size-dependent radiative cooling power of glass-polymer metafilms","authors":"Wenhui Xie , Zhenyu Fan , Gang Tan , Ronggui Yang , Yujie Wei","doi":"10.1016/j.matdes.2025.114095","DOIUrl":"10.1016/j.matdes.2025.114095","url":null,"abstract":"<div><div>Glass-polymer metamaterial, in which glass microspheres are randomly distributed in a polymer matrix, has been demonstrated to be a highly efficient daytime radiative cooling material that can be manufactured via roll-to-roll processes at scale and at low cost. In this work, we conducted a comprehensive study on the effect of size on the radiative cooling power of this hybrid metamaterial, examining the influence of microsphere size, film thickness, and microsphere volume fraction. Our results reveal that the net radiative cooling power increases rapidly with both the microsphere volume fraction and film thickness, although the rate of increase gradually diminishes. In particular, the glass-polymer hybrid metamaterial film, with a thickness as low as 50 μm and containing approximately 8 % SiO<sub>2</sub> microspheres, exhibits uniform and strong emission across the entire atmospheric window. Regarding the effect of microsphere size, the net radiative cooling power initially increases, then slightly decreases before finally reaching a steady plateau. Depending on the microsphere volume fraction and film thickness, the optimal microsphere radius ranges from 1.4 to 4.0 μm. This study provides guidance for numerical calculations in designing similar thermal-control metamaterials.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"254 ","pages":"Article 114095"},"PeriodicalIF":7.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel approach for developing Ti6Al4V-Cu alloy with exceptional properties using a developed metallic printer of LPBF 利用研制的LPBF金属打印机制备性能优异的Ti6Al4V-Cu合金

IF 7.6 2区材料科学

Materials & Design Pub Date : 2025-05-12 DOI: 10.1016/j.matdes.2025.114093

Qinming Gu , Zhenyu Zhang , Hongxiu Zhou , Dong Wang , Yang Gu , Baoshan Zhao , Lijia Yan , Tao Chen , Leilei Chen

{"title":"A novel approach for developing Ti6Al4V-Cu alloy with exceptional properties using a developed metallic printer of LPBF","authors":"Qinming Gu , Zhenyu Zhang , Hongxiu Zhou , Dong Wang , Yang Gu , Baoshan Zhao , Lijia Yan , Tao Chen , Leilei Chen","doi":"10.1016/j.matdes.2025.114093","DOIUrl":"10.1016/j.matdes.2025.114093","url":null,"abstract":"<div><div>Ti6Al4V has no antimicrobial performance, and copper (Cu) is usually added in Ti6Al4V implants. Nevertheless, brittle Ti<sub>2</sub>Cu will be precipitated, greatly affecting the elongation of Ti6Al4V-Cu. To solve these challenges, a novel approach is proposed to prepare Ti6Al4V-Cu alloy using a developed metallic printer of laser powder bed fusion (LPBF). At an optimized laser energy density of 39.51 J/mm<sup>3</sup> and 1 wt% Cu, the relative density of Ti6Al4V-Cu is 99.7 %. The ultimate tensile strength and compressive strength of prepared Ti6Al4V-Cu are 1382.35 and 1882.13 MPa, respectively, representing increases of 14.4 % and 36.9 % compared to those of Ti6Al4V. Meantime, the friction coefficient and wear rate are 0.39 and 3.99 × 10<sup>−4</sup> mm<sup>3</sup>/N∙m, decreasing 46.38 % and 38.29 % correspondingly. Furthermore, electrochemical experiments show that the resistance value of passivated film on Ti6Al4V-Cu is 2.19 × 10<sup>6</sup> Ω·cm<sup>2</sup>, which is 1.38 times that of Ti6Al4V. Cu atoms were dissolved in Ti6Al4V matrix, leading to the decomposition of the Ti<sub>2</sub>Cu phase. The improvement of mechanical, tribological and corrosion resistance properties is attributed to grain refinement, solution strengthening, grain boundary strengthening and decomposition of Ti<sub>2</sub>Cu. Our findings provide new insights to prepare Ti6Al4V-Cu with outstanding properties using LPBF, which has bright prospect in aerospace and medical restorations.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"254 ","pages":"Article 114093"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-optimization of pure Zn via grain refinement and texture design 通过晶粒细化和织构设计对纯锌进行多重优化

IF 7.6 2区材料科学

Materials & Design Pub Date : 2025-05-12 DOI: 10.1016/j.matdes.2025.114065

Jia-You Zhang , Chao Zhou , Zhang-Zhi Shi , Wei Gou , Xiang-Min Li , Qiang Wang , Meng Li , Hai-Jun Zhang , Lu-Ning Wang

引用次数: 0

Achieving strength-plasticity synergy in trace B-modified near β titanium alloy fabricated by laser directed energy deposition 激光定向能沉积制备微量b改性近β钛合金的强度-塑性协同效应

IF 7.6 2区材料科学

Materials & Design Pub Date : 2025-05-12 DOI: 10.1016/j.matdes.2025.114082

Hanlin Ding , Lilin Wang , Lukai Yuan , Haozhi Chai , Jun Yu , Xin Lin , Weidong Huang

{"title":"Achieving strength-plasticity synergy in trace B-modified near β titanium alloy fabricated by laser directed energy deposition","authors":"Hanlin Ding , Lilin Wang , Lukai Yuan , Haozhi Chai , Jun Yu , Xin Lin , Weidong Huang","doi":"10.1016/j.matdes.2025.114082","DOIUrl":"10.1016/j.matdes.2025.114082","url":null,"abstract":"<div><div>Achieving a balance between strength and ductility in additively manufactured near β titanium alloys is challenging. In this study, adding trace B to Ti-5Al-5Mo-5V-3Cr-1Zr significantly enhanced constitutional undercooling and suppressed grain growth, resulting in significant refinement of β grains. During heat treatment, TiB acted as a heterogeneous nucleation site, promoting the coarsening and compositional changes of the primary α phase (α<sub>p</sub>) at elevated temperatures. At subsequent aging, compositional changes of α<sub>p</sub> led to the precipitation of fine secondary α phase, resulting in a dual-sized α phase microstructure. The dual-sized α phase microstructure exhibits a tensile strength of 1059 MPa and an elongation of 15.6 %, whereas the uniform α phase microstructure exhibits a tensile strength of 1139 MPa and an elongation of 2.9 %, exhibiting a slight reduction in strength but a significant improvement in elongation. This can be attributed to: (1) refined grains, which enhanced deformation compatibility and reduced stress/strain localization. (2) Nano-twinning in coarse α<sub>p</sub> is fully activated. (3) The fine grains and coarse primary α phase strongly impede crack propagation. This study demonstrates that trace B enables the regulation of refined β grains and dual-sized α phase in additively manufactured near β titanium alloys, achieving a balance of strength and ductility.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"254 ","pages":"Article 114082"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microstructural and mechanical properties evolution of alloy C-HRA-2 aging at 800 °C for up to 10,000 h C- hra -2合金800℃时效10000 h的组织和力学性能演变

IF 7.6 2区材料科学

Materials & Design Pub Date : 2025-05-11 DOI: 10.1016/j.matdes.2025.114040

Chen Dong , Yuanchao Xu , Hongjian Qian , Lanlan Ma , Quanquan Yang , Zhengjun Wang , Liyuan Li

{"title":"Microstructural and mechanical properties evolution of alloy C-HRA-2 aging at 800 °C for up to 10,000 h","authors":"Chen Dong , Yuanchao Xu , Hongjian Qian , Lanlan Ma , Quanquan Yang , Zhengjun Wang , Liyuan Li","doi":"10.1016/j.matdes.2025.114040","DOIUrl":"10.1016/j.matdes.2025.114040","url":null,"abstract":"<div><div>The microstructural and mechanical properties of alloy C-HRA-2 aged at 800 °C were investigated. For up to 10,000 h, the mechanical properties remain stable. The yield strength is maintained at 410–425 MPa, and the tensile strength is maintained at 840–870 MPa, the elongation and area reduction are maintained at 40–45 %, and the impact toughness is maintained at 125–145 J. The main precipitate during the aging is M<sub>23</sub>C<sub>6</sub>, which is mainly needle/rod-shaped at the interior grain and granular at the grain boundary. A small amount of M<sub>6</sub>C and MX phases are also found at the grain boundary. After long-term aging, the needle/rod M<sub>23</sub>C<sub>6</sub> gradually evolved into granular M<sub>23</sub>C<sub>6</sub>. The contribution to the alloy’s yield strength during the aging process mainly comes from solid solution strengthening (around 220–230 MPa) and M<sub>23</sub>C<sub>6</sub> precipitation strengthening (around 110–120 MPa). Compared with the alloy aged at 700 °C, its yield strength after aging at 800 °C is reduced by about 50 MPa. The main reason is that the needle/rod M<sub>23</sub>C<sub>6</sub> in the grain becomes coarser at higher temperatures.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"254 ","pages":"Article 114040"},"PeriodicalIF":7.6,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospun nanofiber-enabled cascade fenton-like/nitric oxide strategy for enhanced intraperitoneal chemotherapy in advanced gastric cancer with peritoneal metastases 电纺丝纳米纤维驱动级联芬顿样/一氧化氮策略在伴有腹膜转移的晚期胃癌中增强腹腔化疗

IF 7.6 2区材料科学

Materials & Design Pub Date : 2025-05-11 DOI: 10.1016/j.matdes.2025.114083

Xian Li , DongMing Li , Haozheng Wang , Zhifang Ma , Qiang Shi , Jinhai Yu

{"title":"Electrospun nanofiber-enabled cascade fenton-like/nitric oxide strategy for enhanced intraperitoneal chemotherapy in advanced gastric cancer with peritoneal metastases","authors":"Xian Li , DongMing Li , Haozheng Wang , Zhifang Ma , Qiang Shi , Jinhai Yu","doi":"10.1016/j.matdes.2025.114083","DOIUrl":"10.1016/j.matdes.2025.114083","url":null,"abstract":"<div><div>Advanced gastric cancer (GC) with peritoneal metastases (PM) remains challenging due to limited efficacy of conventional therapies and severe complications from intraperitoneal chemotherapy (IPC). To address these limitations, we have developed a novel therapeutic electrospun nanofiber (PTX/GSNO@HKUST-1/PLEA). This composite anti-cancer material enables the continuous release of the paclitaxel (PTX) within the abdominal cavity. Concurrently, it responds to the overexpression of glutathione (GSH) in the acidic environment of tumor cells, converting Cu<sup>2+</sup> into Cu<sup>+</sup>. The generated Cu<sup>+</sup> subsequently produces cytotoxic hydroxyl radicals (<sup><img></sup>OH) via the Fenton reaction. Ultimately, Cu<sup>+</sup> stimulates the release of nitric oxide (NO) from S-nitrosoglutathione (GSNO). The chemodynamic therapy (CDT) mediated by the Fenton reaction significantly enhances the efficacy of IPC. Additionally, NO mitigates the hypoxic state of tumor tissues and decreases the hypoxia-inducible factor protein-1α (HIF-1α) expression, thereby improving the sensitivity and effectiveness of both IPC and CDT. This multimodal therapy synergistically combines potent anticancer efficacy with high biocompatibility and safety. In a mouse model of PM, PTX/GSNO@HKUST-1/PLEA membranes effectively suppressed tumor growth, significantly reduced ascites formation, relieved cancer cachexia, and extended survival. These results highlight the substantial potential of this novel nanofiber membrane for treating PM in advanced GC cases.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"254 ","pages":"Article 114083"},"PeriodicalIF":7.6,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0