Materials & Design最新文献

{"title":"Prussian blue nanohybrid hydrogel combined with specific far-infrared based on graphene devices for promoting diabetic wound healing","authors":"Tingting Yu ,&nbsp;Jiamin Zhang ,&nbsp;Junwei Lai ,&nbsp;Manjiao Deng ,&nbsp;Ziying Zhou ,&nbsp;Zhanbin Xia ,&nbsp;Caiying Zhong ,&nbsp;Xinyue Feng ,&nbsp;Yimin Hu ,&nbsp;XuRan Guo ,&nbsp;Wei Wei ,&nbsp;Weichen Gao ,&nbsp;Yi Zhang ,&nbsp;Zhaobin Guo ,&nbsp;Ke Hu","doi":"10.1016/j.matdes.2025.113839","DOIUrl":"10.1016/j.matdes.2025.113839","url":null,"abstract":"<div><div>Diabetic wounds are difficult to treat in nature due to their distinct pathophysiological characteristics, such as inflammation and/or oxidative stress, which offers an opportunity to employ nanozymes. However, nanozymes may cause safety concerns regarding the balance between enzymatic activity and cytotoxicity, as well as unclear metabolic pathways when used as free nanoparticles. To address this issue, we developed a Prussian blue nanohybrid hydrogel by pre-coupling of polymer materials and inorganic nanomaterials <em>via</em> covalent bond, improving the stability of the organic–inorganic interface as well as nanozymes within the nanohybrid hydrogel. The nanohybrid hydrogel retained the enzymatic activities of Prussian blue nanoparticles, and its enzymatic activities displayed temperature-dependent characteristics when in proximity to physiological temperature. In light of this, we combined graphene-based far-infrared photothermal therapy with nanohybrid hydrogel materials, in order to promote wound healing by thermal effects and improved enzymatic activity. Animal experiments demonstrated that this combination significantly accelerates diabetes wound healing, alleviating wound inflammatory responses, and promote collagen deposition and neovascularization. This innovative approach holds considerable promise for advancing the therapeutic potential of diabetic wound healing and offers new avenues for the development of next generation wound healing treatments.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113839"},"PeriodicalIF":7.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing nanoscale coherent double-solid-solution interfaces between non-reactive Mg and steel alloys","authors":"Qiang Lang ,&nbsp;Taotao Li ,&nbsp;Muhammad Shehryar Khan ,&nbsp;Gang Song ,&nbsp;Liming Liu","doi":"10.1016/j.matdes.2025.113834","DOIUrl":"10.1016/j.matdes.2025.113834","url":null,"abstract":"<div><div>Achieving coherent interface matching between immiscible Mg and Fe alloys is a significant challenge due to significant differences in their lattice constants and structures. Although the introduction of a third element into the interfacial metallurgical reaction has been explored before, it has been difficult to avoid the formation of brittle intermetallic compounds with poor mechanical properties. This study presents a groundbreaking method that, for the first time in published literature, leverages in-situ Ni alloying with a flexible laser-arc hybrid heat source to create an exceptionally high-performing nanoscale double solid solution interface between immiscible Mg and Fe alloys. This processing approach enables the high metallurgical reaction temperatures required for immiscible and nonreactive systems. The resulting lattice formation, driven by localized elemental diffusion at elevated interfacial temperatures, fosters adaptive coherent matching across the entire Mg-Fe interface. This process successfully transforms the non-coherent lattice that is generally observed at the Mg/Fe interface into a coherent double solid solution interface with the bulk matrix on both sides, significantly enhancing bonding efficiency and performance. This study provides detailed advanced characterization of the nanoscale double solid solution structures observed at the interfaces of these immiscible dissimilar metals which has been previously unexplored in the literature.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113834"},"PeriodicalIF":7.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid Metal-Graphene composite conductive nanofiber flexible pressure sensor for dynamic health monitoring","authors":"Manfeng Gong ,&nbsp;Chenglong Tu ,&nbsp;Xitong Lin ,&nbsp;Fang Wang ,&nbsp;Haishan Lian ,&nbsp;Zaifu Cui ,&nbsp;Xiaojun Chen","doi":"10.1016/j.matdes.2025.113811","DOIUrl":"10.1016/j.matdes.2025.113811","url":null,"abstract":"<div><div>Flexible pressure sensors nanofibers-based have garnered significant attention due to their applications in smart wearable devices, healthcare monitoring, human–computer interaction, and artificial intelligence. However, developing flexible pressure sensors with excellent conductivity and stability for stable monitoring of small pressures remains a considerable challenge. This study presents a highly sensitive and rapid-response flexible pressure sensor using liquid metal-graphene composite conductive nanofibers. The sensor employs electrospinning and electrostatic spraying techniques to prepare a liquid metal-polyimide matrix material, with polyvinyl alcohol modification significantly enhancing its adhesion. Notably, an ultrasonic impregnation method was utilized to uniformly disperse conductive fillers onto the surfaces of the nanofibers and within the three-dimensional skeletal structure, creating a dual-conductive network that enhances the sensor’s conductivity. The sensor exhibits high sensitivity (3.02 kPa⁻¹), rapid response/recovery times (80 ms/200 ms), and a broad detection range (0–90 kPa), along with excellent mechanical stability and durability (5000 loading–unloading cycles). These advantages enable the flexible pressure sensor to detect various signals from minor body movements to larger motions, such as throat swallowing and finger bending. This research provides an effective method for continuous health monitoring and the identification of subtle physiological changes, showcasing its tremendous potential in the fields of smart robotics and prosthetics.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"252 ","pages":"Article 113811"},"PeriodicalIF":7.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, optimization, and validation of a magnetic mother-child robot system for targeted drug delivery","authors":"Bentao Zou ,&nbsp;Huibin Liu ,&nbsp;Xuehao Fen ,&nbsp;Zhizheng Gao ,&nbsp;Zhixing Ge ,&nbsp;Wenguang Yang","doi":"10.1016/j.matdes.2025.113827","DOIUrl":"10.1016/j.matdes.2025.113827","url":null,"abstract":"<div><div>Traditional untethered magnetic microrobots utilized for in vivo targeted drug delivery face challenges related to poor maneuverability and limited kinematic performance. In this study, we harness the strengths of both magnetic continuum robots (acting as “mother” units) and untethered microrobots (functioning as “child” units), refining the motion model to develop a magnetically driven mother–child robotic system. We have also enhanced the structural design of the magnetic continuum and optimized the batch fabrication process of pH-responsive hydrogel integrated with the microrobots. This design allows the child robots to be deployed by the mother unit and subsequently retrieved upon task completion. Our strategy, which aims to minimize foreign body presence and reduce side effects, was validated using an in vitro gastric model, demonstrating the feasibility and enhanced operability of this system.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113827"},"PeriodicalIF":7.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating Structure-Property relationships for optimization of plate lattice sound absorbers","authors":"Jun Wei Chua ,&nbsp;Wei Zhai ,&nbsp;Xinwei Li","doi":"10.1016/j.matdes.2025.113801","DOIUrl":"10.1016/j.matdes.2025.113801","url":null,"abstract":"<div><div>To be compatible with mainstream additive manufacturing techniques, plate lattices must be designed with embedded pores to eliminate closed cells and facilitate material removal. Interestingly, these pores also transform the plate lattices into effective acoustic absorbers, with structures resembling Helmholtz resonators. In this work, the sound absorption performance of plate lattices inspired by crystal structures was investigated, with small perforations at nodes introduced as a design feature to facilitate feedstock material removal and allow acoustic energy to penetrate the structure. Calibrated through numerous additively manufactured samples, a high-fidelity mathematical model, grounded in Helmholtz resonance principles and the Transfer Matrix Method, was developed to accurately predict the acoustic properties of plate lattices across a broad range of frequencies from 450 to 6300 Hz. The model not only effectively predicts sound absorption coefficient curves based on geometric parameters but also provides valuable insights into how these parameters influence acoustic performance. It is found that smaller cell sizes, higher relative densities, and reduced perforation sizes generally result in higher mean sound absorption coefficients. The frequency bands of peak absorption regions are then strongly affected by the perforation size relative to the cell size. Furthermore, an optimization framework leveraging the model generated heterogeneous plate lattice designs with superior broadband sound absorption at targeted frequency ranges. This work introduces a robust mathematical approach for predicting and optimizing the acoustic properties of perforated plate lattices while uncovering key structural-property relationships that drive their performance.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113801"},"PeriodicalIF":7.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design strategy for Al-containing metallic glasses by entropy engineering and covalent attribute","authors":"Bing-Tao Wang ,&nbsp;Zi-Jing Li ,&nbsp;Shi-Dong Feng ,&nbsp;Li-Min Wang","doi":"10.1016/j.matdes.2025.113771","DOIUrl":"10.1016/j.matdes.2025.113771","url":null,"abstract":"<div><div>Traditional approaches to the composition design of metallic glasses often disregard the distinct nature of metallic and covalent interactions, leading to challenges in accurately incorporating specific elements that are more covalent and understanding their interactions. This limitation complicates the quantitative design process and hinders the development of a comprehensive theoretical framework. To address this, we propose a novel design strategy based on entropy engineering to tune metallic bonds using melting entropy, while the covalent interactions is guided by mixing enthalpy. Applying this method, we successfully designed the metallic glasses <span><math><msub><mrow><mtext>La</mtext></mrow><mrow><mn>60.6</mn></mrow></msub><msub><mrow><mtext>Ni</mtext></mrow><mrow><mn>22.9</mn></mrow></msub><msub><mrow><mtext>Al</mtext></mrow><mrow><mn>17.5</mn></mrow></msub></math></span> and <span><math><msub><mrow><mi>La</mi></mrow><mrow><mn>62.2</mn></mrow></msub></math></span><span><math><msub><mrow><mi>Ni</mi></mrow><mrow><mn>11.8</mn></mrow></msub></math></span><span><math><msub><mrow><mi>Cu</mi></mrow><mrow><mn>12.7</mn></mrow></msub></math></span><span><math><msub><mrow><mi>Al</mi></mrow><mrow><mn>13.2</mn></mrow></msub></math></span> whose GFA is highly consistent with the reported components.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"252 ","pages":"Article 113771"},"PeriodicalIF":7.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct evidence and kinetics of Cu precipitation in the austenite phase of a maraging stainless steel","authors":"Tao Zhou ,&nbsp;Gabriel Spartacus ,&nbsp;Xiaoqing Li ,&nbsp;Sonia Guehairia ,&nbsp;Tim Fischer ,&nbsp;Malte Blankenburg ,&nbsp;Peter Hedström","doi":"10.1016/j.matdes.2025.113835","DOIUrl":"10.1016/j.matdes.2025.113835","url":null,"abstract":"<div><div>In this study, we investigate the precipitation kinetics of Cu in 15–5 PH maraging stainless steel during high-temperature thermal treatments in the fully austenitic state. This provides direct evidence that Cu precipitation can occur in the austenite phase of martensitic or ferritic steels. The kinetics of Cu precipitation in austenite are examined at 700 and 800 °C using <em>in situ</em> synchrotron small-angle and wide-angle X-ray scattering, complemented by atom probe tomography investigations to analyze the precipitates, particularly their chemistry, following heat treatment. The resulting experimental data, which include the evolution of size, volume fraction, number density and chemical composition, are used to inform precipitation kinetics modelling using the Langer-Schwartz-Kampmann-Wagner (LSKW) approach coupled with CALPHAD thermodynamic and kinetic databases. The simulations accurately capture the experimental data by adjusting the interfacial energy in an inverse modelling approach. The insight that Cu precipitation occurs in austenite and subsequently in martensite paves the way for design of hierarchical structures with a bi-modal particle size distribution of Cu precipitates with varying crystal structures and compositions. Additionally, the validated LSKW modelling approach establishes a foundation for designing Cu-alloyed high-performance steels, taking into account various manufacturing routes.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"252 ","pages":"Article 113835"},"PeriodicalIF":7.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermophysical and microstructural characterization of Ti-6Al-4V in powder and laser powder bed fusion-processed state within the global temperature field range","authors":"J. Rottler ,&nbsp;T.K. Tetzlaff ,&nbsp;A. Wohninsland ,&nbsp;A. Lion ,&nbsp;M. Johlitz","doi":"10.1016/j.matdes.2025.113823","DOIUrl":"10.1016/j.matdes.2025.113823","url":null,"abstract":"<div><div>To pave the way for thermophysical modeling and further PBF-LB/M process optimization, the thermophysical properties of Ti-6Al-4V in powder and processed states were investigated using thermo-mechanical analysis, laser flash analysis, and differential scanning calorimetry. Microstructural characterization using SEM, Vickers hardness testing, and XRD facilitated a novel interpretation of the results. The macroscopic density exhibited a linear relationship up to 880<!--> <span><math><mmultiscripts><mrow><mi>C</mi></mrow><mprescripts></mprescripts><none></none><mrow><mo>∘</mo></mrow></mmultiscripts></math></span>, showing only a minor impact from microstructural effects. The evolution of <span><math><msup><mrow><mi>α</mi></mrow><mrow><mo>′</mo></mrow></msup></math></span> martensitic microstructure was analyzed by examining linear thermal expansion coefficients indicating direction dependency. During heating, the precipitation and stabilization of <em>β</em> provoke the formation and decomposition of the intermetallic phase, accompanied by a significant increase in hardness and an exothermic event. Additionally, the relaxation of residual stresses and transformation into the <em>β</em> phase determines the microstructural evolution. Thermal diffusivity of as-built Ti-6Al-4V propagates linearly up to 950<!--> <span><math><mmultiscripts><mrow><mi>C</mi></mrow><mprescripts></mprescripts><none></none><mrow><mo>∘</mo></mrow></mmultiscripts></math></span>. For powder, HotDisk measurements corroborate laser flash data obtained up to 850<!--> <span><math><mmultiscripts><mrow><mi>C</mi></mrow><mprescripts></mprescripts><none></none><mrow><mo>∘</mo></mrow></mmultiscripts></math></span>. Based on the LFA, the start of sintering is identified and attributed to a change in the heat transfer mechanism in AM powders. Specific heat capacity and effective thermal conductivity of AM Ti-6Al-4V are determined, highlighting the shortcomings of predicting AM powders' conductivity based on solid materials.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113823"},"PeriodicalIF":7.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravitreal injection of TA-III with sustained release to simultaneously impart anti-inflammatory, antioxidative, and vascular remodeling activities in diabetic retinopathy","authors":"Jie Zhang ,&nbsp;Yu Liu ,&nbsp;Yu Gong ,&nbsp;Yanyu Shangguan ,&nbsp;Pengli Wang ,&nbsp;Yanlong Bi ,&nbsp;Yong Xu ,&nbsp;Bo Tao ,&nbsp;Bing Li","doi":"10.1016/j.matdes.2025.113832","DOIUrl":"10.1016/j.matdes.2025.113832","url":null,"abstract":"<div><div>Diabetes negatively impacts vision and retinal function. However, current therapeutic options for diabetic retinopathy (DR) often present limitations, including targeting specific pathways, short duration of action, and need for frequent injections. Timosaponin AIII (TA-III) exhibited the potential of anti-inflammation, anti-oxidative stress and promoting vascular remodeling abilities from bioinformatics analysis tool. Additionally, polyethylene glycol succinimide succinate [PEG-(SS)₂]-human serum albumin (HSA) (Hp) hydrogel, known for its excellent biocompatibility and sustained drug release properties, was employed to encapsulate TA-III to exhibit a long-acting, sustained release profile. In vitro results demonstrated that the TA-III/Hp hydrogel upregulated the expression of vascular endothelial growth factor receptor 2 and zonula occludens-1, while reducing the level of vascular endothelial growth factor A. We further observed a significant reduction in the levels of reactive oxygen species, malondialdehyde, interleukin-1β, interleukin-6, and tumor necrosis factor-α under high glucose conditions by using the TA-III/Hp hydrogel in retinal pigment epithelium cells. Notably, intravitreal delivery of TA-III/Hp hydrogel in the DR mouse model effectively increased retinal thickness and numbers of mature blood vessels, while inhibiting oxidative stress and inflammatory factor levels. In conclusion, intravitreal injection of TA-III/Hp hydrogel facilitates sustained release of TA-III, simultaneously providing anti-inflammatory, antioxidative, and vascular remodeling effects in DR.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113832"},"PeriodicalIF":7.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient design of Voronoi energy-absorbing foams using Bayesian optimization","authors":"Youngtaek Oh ,&nbsp;Byungjo Kim ,&nbsp;Hayoung Chung","doi":"10.1016/j.matdes.2025.113822","DOIUrl":"10.1016/j.matdes.2025.113822","url":null,"abstract":"<div><div>Recently, many studies have increasingly focused on developing bio-inspired structures, leveraging their lightweight and high-energy absorption properties, which are crucial across many engineering fields. Structural optimization aiming for bio-inspired structures having superior energy absorption capability, however, has been considered a challenging problem. One of these challenges is that nonlinear material behaviors induced by external forces, such as buckling and self-contact of constituting ligaments, intervene in the energy absorption process. Such nonlinearities not only make the relationship between design changes and energy absorption nonlinear, but also exacerbate the difficulties of design, given the complexity of the ligament configurations. To address this, a novel design optimization method for bio-inspired cellular structures with high energy absorption is proposed. First, Voronoi tessellation is used to capture configurations of bio-inspired material, parameterized by geometric variables. Then, Bayesian optimization with Kriging efficiently updates the design, exploring the complex design space through high-fidelity nonlinear finite element analysis. The proposed design method is efficient in structural optimization as it combines a strategy to reduce the number of samples required for surrogate modeling of structural response and optimal search, but it also generates multiple design outcomes with similar advantages due to the intrinsic variance of the Voronoi structures.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113822"},"PeriodicalIF":7.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}