Materials & Design最新文献

{"title":"Multifunctional nanofiber-based dressings in coordination with adipose-derived stem cells for accelerated burn wound healing","authors":"Ziyi Zhou ,&nbsp;Yuanfei Wang ,&nbsp;Na Liu ,&nbsp;Xiaopei Zhang ,&nbsp;Xuchao Ning ,&nbsp;Yuanxin Miao ,&nbsp;Chuanglong He ,&nbsp;Tong Wu ,&nbsp;Xiangfeng Leng","doi":"10.1016/j.matdes.2025.113929","DOIUrl":"10.1016/j.matdes.2025.113929","url":null,"abstract":"<div><div>Burn wound healing remains a significant clinical challenge due to infections and poor tissue regeneration. To address this issue, we developed a tri-layered wound dressing (TLWD) integrated with adipose-derived stem cells (ADSCs, TLWDA) to accelerate burn wound repair. The outer layer consists of radially aligned nanofibers coated with a gradient of epidermal growth factor (EGF) to promote epidermal regeneration. The middle layer is composed of dense gelatin nanofibers coated with methacrylate-chitosan hydrogel, providing mechanical support and antimicrobial properties. The inner layer features mesh-structured nanoyarns coated with gelatin nanofibers, which can regulate the paracrine secretion of ADSCs. Antibacterial assay and live/dead bacterial staining confirmed that the TLWDA scaffold exhibits excellent antimicrobial activity. Scratch assays demonstrated that TLWDA enhances the migration of keratinocytes, fibroblasts, and endothelial cells. Additionally, TLWDA markedly improves angiogenesis and upregulates the secretion of EGF and fibroblast growth factor (FGF2) from ADSCs. <em>In vivo</em> experiments, compared to TLWD or ADSCs alone, TLWDA significantly accelerates the healing process of burn wounds, while improving the thickness of the regenerated epidermal layer, collagen deposition, and vascularization. The synergistic effect of this multifunctional nanofiber-based composite scaffold with ADSCs offers a highly promising strategy for the effective repair of burn wounds.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113929"},"PeriodicalIF":7.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable glycyrrhizic acid-based hydrogel with Immunoregulatory and angiogenic properties for diabetic wound healing","authors":"Haisheng Wu ,&nbsp;Zichao Xue ,&nbsp;Zhigang Wang ,&nbsp;Jiacai Mei ,&nbsp;Mingzhe Shao ,&nbsp;Jian Zhang ,&nbsp;Haiyang Hu ,&nbsp;Ye Pan","doi":"10.1016/j.matdes.2025.113928","DOIUrl":"10.1016/j.matdes.2025.113928","url":null,"abstract":"<div><div>Diabetic wound healing (DWH) demands multifunctional dressings capable of delivering therapeutic agents to counteract the impaired repair microenvironment. Elevated oxidative stress and chronic inflammation not only suppress regenerative cell viability but also exacerbate apoptosis and vascular dysfunction, collectively hindering wound healing. To address these challenges, we developed an injectable dual-network hydrogel dressing based on immunomodulatory and pro-angiogenic glycyrrhizic acid (GA). This hydrogel combines<!--> <!-->alkylated glycyrrhizinic acid (AGA)<!--> <!-->and<!--> <!-->methacrylated sericin (SFMA)<!--> <!-->to form a natural extracellular matrix (ECM)-mimetic dual network, achieving both excellent injectability and enhanced mechanical properties. Furthermore, the hydrogel incorporates the pro-angiogenic agent<!--> <!-->desferrioxamine (DFO)<!--> <!-->through dynamic covalent bonding, enabling sustained drug release. The resulting<!--> <!-->AGA/SFMA@DFO hydrogel<!--> <!-->effectively modulates macrophage polarization and enhances vascular regeneration under inflammatory conditions. Additionally, the residual aldehyde groups in the<!--> <!-->AGA/SFMA@DFO<!--> <!-->gel form Schiff base linkages with amino groups on the skin surface, ensuring strong tissue adhesion. Consequently, this multifunctional hydrogel dressing demonstrates significant potential in accelerating diabetic wound repair.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113928"},"PeriodicalIF":7.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superlubricity enabled by graphene nanocomposite film on carbon-coated AISI 1045 steel","authors":"Tabiri Kwayie Asumadu ,&nbsp;Mobin Vandadi ,&nbsp;Desmond Edem Primus Klenam ,&nbsp;Kwadwo Mensah-Darkwa ,&nbsp;Kwadwo Adinkrah-Appiah ,&nbsp;Emmanuel Gikunoo ,&nbsp;Nima Rahbar ,&nbsp;Samuel Kwofie ,&nbsp;Winston Oluwole Soboyejo","doi":"10.1016/j.matdes.2025.113916","DOIUrl":"10.1016/j.matdes.2025.113916","url":null,"abstract":"<div><div>This paper presents a low-cost and innovative method for treating high temperature biowaste to create an ultra-low friction carbon-based coating on AISI 1045 steel. Utilizing carbon from Manihot esculenta biowaste, graphene variants were deposited on substrates at 500 °C and 900 °C. The microstructure and mechanical/tribological properties were studied pre- and post-treatment. These include Vickers hardness and wear characteristics that were measured with a ball-on-disk wear tester. Increasing treatment temperature and time resulted in high substrate hardness. The graphene variants were characterized using Raman spectroscopy with discernible trends D and G band trends. The I_2D/I_G and I_D/I_G intensity ratios varied as the treatment conditions changed. Electron backscatter diffraction, X-ray diffraction, optical, scanning electron, and atomic force microscopy provided insights into phases and microstructural features. Tribological tests showed remarkable ∼95.20 % reduction with a superlubricious coefficient of friction of ∼0.0015 and ∼88 % decreased wear rate for substrates treated for 5 h at 900 °C. The graphene platelet and multiwalled defective structures on the substrates transformed into graphene oxide and graphene nanocrystals providing the needed solid lubrication. The underlying mechanisms are discussed before elucidating the implications of the result for the design of rigorous, novel carbon coatings for frictionless and ultralow-wear surfaces in a circular economy.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113916"},"PeriodicalIF":7.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of melting mode on melt pool dynamics and microstructure in WE43 Mg alloy: A combined computational and experimental approach","authors":"Francesco D’Elia ,&nbsp;Mohammad Hoseini-Athar ,&nbsp;Satya Chaitanya Vaddamanu ,&nbsp;Mikael Ersson ,&nbsp;Peter Hedström ,&nbsp;Cecilia Persson","doi":"10.1016/j.matdes.2025.113925","DOIUrl":"10.1016/j.matdes.2025.113925","url":null,"abstract":"<div><div>In this study, laser-material interactions during laser-powder bed fusion of WE43 magnesium alloy were characterized through numerical and experimental analyses. Various melting modes (i.e., conduction, transition, and keyhole) were induced through deposition of laser tracks at powers ranging from 80 to 130 W, and used as input parameters for a thermo-fluid model. Results of microscopy demonstrated good agreement between numerical and experimental measurements of melt pool depth, as well as a strong correlation between melt pool microstructure and the thermo-fluid conditions predicted by the model. Specifically, for conduction mode at 80 W, a predominance of cellular subgrains within the melt pool was consistent with the predicted steep thermal gradients, while for keyhole mode at 130 W, low thermal gradients correlated with high presence of equiaxed dendrites. Moreover, convection currents attributed to high recoil pressure in keyhole melt pools, were in agreement with locations of numerous subgrain boundaries having non-uniform morphologies, while under conduction, outward Marangoni flow led to a unique alignment of cellular subgrains and fewer subgrain boundaries. This study demonstrates the interplay among processing, thermal history, fluid flow and microstructure in WE43, and provides a basis for future design of microstructures for improved material properties.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113925"},"PeriodicalIF":7.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of tranexamic acid-functionalized photothermal hydrothermal treated oxidized graphene sponge on diabetic wound healing: Hemostasis, antibacterial, and regeneration","authors":"Chaoyang Huang ,&nbsp;Lianglong Chen ,&nbsp;Xiaoyang Liu ,&nbsp;Yanqi Chen ,&nbsp;Xian Li ,&nbsp;Qiulan Wen ,&nbsp;Hai Zhou ,&nbsp;Bo Liu ,&nbsp;Lei Yang ,&nbsp;Pengwei Shi","doi":"10.1016/j.matdes.2025.113915","DOIUrl":"10.1016/j.matdes.2025.113915","url":null,"abstract":"<div><div>In the healing process of chronic diabetic wounds, a prolonged inflammatory phase and an increased number of inflammatory cells consuming large amounts of oxygen create a hypoxic environment around the wound. Under such conditions, prolonged hypoxia inhibits angiogenesis and extracellular matrix (ECM) synthesis, reducing the nutrient supply to the injured area, thereby impeding further healing. Therefore, promoting tissue vascularization and enhancing nutrient delivery are crucial for facilitating tissue repair processes. To address this issue, we developed a graphene oxide (GO)-decellularized dermal matrix sponge (PGO_0.35T₁) with photothermal bath functionality. Through photothermal conversion, this sponge not only enhances cellular adaptation to oxygen and remodels the local tissue microenvironment, effectively regulating cellular metabolism, but also absorbs substantial light energy, achieving bacterial eradication via localized hyperthermia. Additionally, owing to the modification with tranexamic acid, this extracellular matrix sponge exhibits excellent hemostatic properties. In vitro experimental results demonstrated that the three-dimensional sponge scaffold possessed favorable cell adhesion, biocompatibility, and bioactivity. In a rat diabetic wound model, the PGO_0.35T₁ sponge scaffold effectively and continuously interacted with the wound, mimicking the role of natural skin, preventing the loss of internal nutrients, and creating a comfortable and conducive microenvironment for tissue regeneration. Furthermore, it enhances epithelialization by increasing the number of microvessels in the skin. Thus, this oxygen-rich short-fiber sponge with photothermal bath functionality regulates cellular metabolism, offering a novel approach for diabetic wound repair through its antibacterial, photothermal, and metabolic-improving properties, with significant clinical implications.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113915"},"PeriodicalIF":7.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of 1000-Line/mm orthogonal grating for Micro-Deformation field mapping","authors":"Xinyun Xie,&nbsp;Qinghua Wang,&nbsp;Xiaojun Yan","doi":"10.1016/j.matdes.2025.113923","DOIUrl":"10.1016/j.matdes.2025.113923","url":null,"abstract":"<div><div>High-frequency gratings are vital for microscale deformation field analysis but face fabrication challenges due to cost and complexity. In this study, we innovatively report a rapid fabrication technique of large-area 1000-line/mm (1 µm pitch) orthogonal grating using maskless lithography with a 405 nm UV light source, and apply it to characterize the microscale slip plastic deformation fields of a Nickel-Based Single Crystal superalloy (NBSC) specimen for the first time. Detailed fabrication parameters and quality assessments were outlined. Moreover, in-situ tensile experiments on NBSC specimen in the [001] tensile direction were performed, and the evolution of the microscale plastic deformation fields was obtained by the sampling moiré method. The results showed that the proposed technique enables the stable fabrication of 1000-line/mm grating with 300 nm feature linewidth, rates up to 20–30 min per 1 mm². The 1000-line/mm grating enables nano-sensitive deformation resolution for plastic deformation displacement fields on the surface of the NBSC specimen. The proposed method provides a feasible deformation carrier fabrication technique to support microscale deformation measurement of various materials.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113923"},"PeriodicalIF":7.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal-targeting bioinspired curcumin framework nanozyme for regulating inflammatory and oxidative stress homeostasis in acute kidney injury","authors":"Xinyue Hou ,&nbsp;Mingyao Hu ,&nbsp;Jie Zhang ,&nbsp;Zhou Li ,&nbsp;Tingting Wu ,&nbsp;Haowei Zhu ,&nbsp;Yi Feng ,&nbsp;Di Zhang ,&nbsp;Wei Jiang ,&nbsp;Zhigang Wang ,&nbsp;Wei Wang ,&nbsp;Wenjun Shang","doi":"10.1016/j.matdes.2025.113900","DOIUrl":"10.1016/j.matdes.2025.113900","url":null,"abstract":"<div><div>Kidney ischemia–reperfusion injury (IRI) is a common and unavoidable pathological condition in transplantation, characterized by elevated levels of endogenous reactive oxygen species (ROS) and inflammation. However, drugs with only antioxidant or anti-inflammatory properties are often insufficient to effectively alleviate IRI. In this study, we developed a platelet membrane-coated curcumin framework nanozyme (PL@Cur-MnZn) that exhibits enhanced antioxidant and anti-inflammatory activities compared to curcumin or Mn-ZIF alone, due to the synergistic effects of the incorporated active agents. The natural affinity of platelets endows PL@Cur-MnZn with efficient renal targeting ability, leveraging the homing properties of platelets. These particles demonstrated significant cytoprotective effects and reduced kidney IRI both <em>in vitro</em> and in vivo, without noticeable toxicity. This was achieved by inhibiting cell apoptosis and enhancing Nrf2 activation, which in turn activates the endogenous Nrf2-Keap1-ARE signaling pathway. This leads to synergistic antioxidant effects from both external and internal sources, further alleviating renal IRI. Therefore, PL@Cur-MnZn holds potential as an effective therapeutic agent for managing kidney IRI and could contribute to advancing clinical treatment strategies for this condition.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113900"},"PeriodicalIF":7.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manufacturing and impact resistance of Large-Scale stacked fibre metal laminates","authors":"Ding Tang,&nbsp;Haoyang Huang,&nbsp;Yitong Fan,&nbsp;Huamiao Wang,&nbsp;Yinghong Peng","doi":"10.1016/j.matdes.2025.113917","DOIUrl":"10.1016/j.matdes.2025.113917","url":null,"abstract":"<div><div>This study introduces an automatic manufacturing process for large-scale stacked fibre metal laminates (FMLs) to reduce costs compared to traditional methods. A 3D finite element model was developed using Abaqus/Explicit, incorporating the Johnson─Cook, 3D-Hashin progressive damage, and cohesive surface models to evaluate the impact resistance of the produced FMLs. Charpy and ballistic impact tests validated the model’s accuracy. This study investigates the impact resistance for these conditions. For the Charpy impact, we compared the impact resistance of monolithic aluminium plates, laminated aluminium plates, carbon FMLs, and glass FMLs and observed a progressive increase in energy absorption across these types. Increasing the composite layer thickness shifted the initial failure mode from bottom fracture to shear failure of the middle layer, resulting in decreased energy absorption and increased bending modulus. The influence of the impact angle was examined under ballistic impact, revealing that larger angles resulted in higher energy absorption in cases of complete bullet penetration. Compared to monolithic aluminium plates, large-scale stacked FMLs absorbed less energy but offered significant weight reduction. This study provides a theoretical foundation for optimizing material design and enhancing structural safety.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113917"},"PeriodicalIF":7.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of an ultra-wideband flexible optically transparent metamaterial absorber with wide-angle and polarization stability","authors":"Jinhuan Zhang,&nbsp;Shengji Zhang,&nbsp;Jian Dong,&nbsp;Meng Wang,&nbsp;Heng Luo,&nbsp;Rigeng Wu,&nbsp;Chengwang Xiao","doi":"10.1016/j.matdes.2025.113921","DOIUrl":"10.1016/j.matdes.2025.113921","url":null,"abstract":"<div><div>In this paper, an ultra-wideband, flexible, and optically transparent metamaterial absorber (MA) is proposed. The MA is devised from an Indium Tin Oxide (ITO) resistive film on a flexible transparent polyethylene terephthalate (PET) substrate, which ensures reliable performance on curved surfaces. Remarkably, The MA features stable absorption across a frequency range of 3.93 GHz to 27.45 GHz, achieving an absorption bandwidth of 149.9 % that encompasses the entire C-, X-, Ku-, and K-bands. Moreover, the proposed MA exhibits polarization insensitivity and stability under incidence angles up to 60°, achieving a 10 dB reduction in radar cross section (RCS) for both planar and curved configurations. Equivalent circuit model theory and impedance matching theory, as well as further discussion of current and field distributions, are undertaken to elucidate the underlying physical mechanisms. Subsequently, a prototype is fabricated and experimentally tested, with the measured results closely aligning with simulation results, thereby confirming the absorber’s robust absorption capabilities and applicability in microwave stealth applications.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113921"},"PeriodicalIF":7.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed prosthetic foot design: Mechanical similarity and testing","authors":"Ana María Gómez-Amador ,&nbsp;Carlos Pérez-Carrera ,&nbsp;Leopoldo Prieto-Fernández ,&nbsp;Higinio Rubio-Alonso","doi":"10.1016/j.matdes.2025.113918","DOIUrl":"10.1016/j.matdes.2025.113918","url":null,"abstract":"<div><div>This study introduces a novel, accessible approach for designing a lower-limb prosthetic foot intended for production on standard 3D printers, thereby making it available to any individual with the requisite resources. A cost-effective prototyping process was employed to minimize material waste and optimize testing through the application of dimensional analysis and scaling methodologies. The methodology was validated for predicting full-scale performance accurately through the testing of smaller-scale prototypes to failure, which preserved the force-to-displacement ratio across scales and achieved a relative error of 3.6%. The prosthesis was found to meet the mechanical requirements of UNE-EN ISO 10328:2016 through static strength testing. The scaled methodology allows for the creation of reliable prostheses at a reduced cost, thereby increasing the accessibility of advanced prosthetic solutions. This research not only corroborates the viability of 3D-printed prostheses for clinical use but also establishes a framework for future designs, offering significant potential for low-cost, scalable solutions in prosthetic engineering.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113918"},"PeriodicalIF":7.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}