Materials & Design最新文献_第10页

Conjugated polymer nanoparticles (CPNs)-based optogenetic platform reprogramming the tumor microenvironment of MSS colorectal cancer 基于共轭聚合物纳米粒子（CPNs）的光遗传平台重编程MSS结直肠癌的肿瘤微环境

IF 7.9 2区材料科学

Materials & Design Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.matdes.2026.115611

Miaomiao Gou , Xuancheng Fu , Gang Song , Chang Liu , Yong Zhang , Fengting Lv , Guanghai Dai

引用次数: 0

Pd-free activation for low-loss silver-coated polymer waveguides in millimeter-wave transmission 毫米波传输中低损耗镀银聚合物波导的无钯活化

IF 7.9 2区材料科学

Materials & Design Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/j.matdes.2026.115607

Yongliu Yu , Jin Leng , Liang-Hui Du , Zhao-Hui Zhai , Peng Chen , Yuxi Liu , Liying Chen , Li-Guo Zhu , Qiwu Shi

{"title":"Pd-free activation for low-loss silver-coated polymer waveguides in millimeter-wave transmission","authors":"Yongliu Yu , Jin Leng , Liang-Hui Du , Zhao-Hui Zhai , Peng Chen , Yuxi Liu , Liying Chen , Li-Guo Zhu , Qiwu Shi","doi":"10.1016/j.matdes.2026.115607","DOIUrl":"10.1016/j.matdes.2026.115607","url":null,"abstract":"<div><div>Waveguides are crucial components for enabling stable signal links in rapidly developing millimeter-wave and terahertz applications. Among various configurations, metal-coated polymeric hollow waveguides offer a compelling combination of low transmission loss, lightweight flexibility, and cost-effectiveness, yet their reliable fabrication remains challenging. The conventional approaches, which typically rely on palladium-based activation to achieve metal-polymer adhesion, suffer from high cost, limited scalability, and environmental concerns. This work proposes a disruptive Pd-free surface modification strategy using a silane coupling agent to address the intrinsic adhesion issue between polycarbonate substrates and silver coatings. The introduced aminosilane layer forms chemical bonds onto the inner surface of a polymer hollow tube, enabling the further growth of silver layer. Through systematic parameter optimization, we fabricated polymer hollow-core waveguide with a silver-plated inner surface, achieving lengths of up to 4 m and a transmission loss as low as 0.73 dB/m at 220 GHz—a value approaching the theoretical limit. Furthermore, we demonstrated a prototype automotive millimeter-wave radar system incorporating the fabricated waveguide for ranging applications. This work establishes a scalable, low-cost, and efficient pathway to high-performance hollow waveguides, suitable for advanced millimeter-wave and terahertz systems in communications, data center interconnects, sensing, and beyond.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"263 ","pages":"Article 115607"},"PeriodicalIF":7.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-density short aspen fiber networks have similar tensile properties as networks from longer spruce fibers 高密度短杨木纤维网与长云杉纤维网具有相似的拉伸性能

IF 7.9 2区材料科学

Materials & Design Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.matdes.2026.115624

Erfan Oliaei , Bin Chen , Per-Oskar Westin , Lars A. Berglund

引用次数: 0

Magnesium phosphate cement modulates osteosarcoma stemness and osteogenesis via IGFBP5 activation for localized tumor therapy 磷酸镁水泥通过激活IGFBP5调控骨肉瘤的干性和成骨作用，用于局部肿瘤治疗

IF 7.9 2区材料科学

Materials & Design Pub Date : 2026-03-01 Epub Date: 2026-02-10 DOI: 10.1016/j.matdes.2026.115643

Ling Yu , Jingteng Chen , Dongdong Shi , Shiyu Li, Zhangxin Chen, Weichun Guo

{"title":"Magnesium phosphate cement modulates osteosarcoma stemness and osteogenesis via IGFBP5 activation for localized tumor therapy","authors":"Ling Yu , Jingteng Chen , Dongdong Shi , Shiyu Li, Zhangxin Chen, Weichun Guo","doi":"10.1016/j.matdes.2026.115643","DOIUrl":"10.1016/j.matdes.2026.115643","url":null,"abstract":"<div><div>Osteosarcoma remains a clinical challenge due to aggressive bone destruction and cancer stem cell (CSC)-driven recurrence. While magnesium phosphate cement (MPC) is widely recognized for its osteoregenerative properties, its therapeutic potential in bone malignancies is largely unexplored. Here, we systematically evaluated MPCs with varying Mg/P ratios (MPC-1 ∼ 5) for their antitumor and pro-differentiation effects against osteosarcoma. MPC1 ∼ 3 demonstrated dose-dependent suppression of tumor growth, migration, and aggression, while MPC-5 elicited significant cytotoxicity. Notably, MPC-1 ∼ 3 suppressed CSC markers and promoted osteogenic differentiation, evidenced by matrix mineralization and upregulation of osteogenic transcription factors. In orthotopic and metastatic mouse models, MPC treatment significantly reduced tumor burden and pulmonary metastasis, alongside elevated expression of osteogenic markers (OPN, Runx2, Collagen-I). Mechanistically, MPCs upregulated insulin-like growth factor binding protein 5 (IGFBP5), that mediated stemness suppression and differentiation induction; silencing IGFBP5 reversed these effects. These findings identify MPC as a bifunctional biomaterial with both antitumor and osteoinductive properties, offering a promising strategy for osteosarcoma therapy via stemness-targeted differentiation.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"263 ","pages":"Article 115643"},"PeriodicalIF":7.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover_263 Cover_263

IF 7.9 2区材料科学

Materials & Design Pub Date : 2026-03-01 Epub Date: 2026-03-03 DOI: 10.1016/S0264-1275(26)00289-3

引用次数: 0

From external to internal Light: Designs, Mechanisms, applications and Prospects of wireless photodynamic therapy in cancer 从外部光到内部光：无线光动力治疗癌症的设计、机制、应用与展望

IF 7.9 2区材料科学

Materials & Design Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.matdes.2026.115618

Adel Habibul, Jiaquan Mao, Sheng Xin, Jun Zhang, Wen Song, Xiaodong Song, Kun Tang

{"title":"From external to internal Light: Designs, Mechanisms, applications and Prospects of wireless photodynamic therapy in cancer","authors":"Adel Habibul, Jiaquan Mao, Sheng Xin, Jun Zhang, Wen Song, Xiaodong Song, Kun Tang","doi":"10.1016/j.matdes.2026.115618","DOIUrl":"10.1016/j.matdes.2026.115618","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) utilizes light-activated photosensitizers to generate cytotoxic reactive oxygen species (ROS) in tumors and is clinically applied across diverse cancers. Nevertheless, traditional wired-PDT is limited by restricted optical penetration, spatially heterogeneous intratumoral illumination, and the procedural burden of invasive fiber delivery. Wireless PDT addresses these issues by producing photons in situ with implantable opto-electronic devices, light-converting nanomaterials and self-luminescent nanoparticles, thereby activating photosensitizers from inside the body. This mode of wireless PDT improves depth reach and spatial uniformity while omitting fiber-based access, and it permits a more feasible way for metronomic PDT that sustains intratumoral oxygenation and ROS production while minimizing thermal damage and hypoxia-driven immunosuppression. Building on these advances, we elaborate the idea of wireless PDT and outline a novel contour for the future of photodynamic therapy in cancer treatment.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"263 ","pages":"Article 115618"},"PeriodicalIF":7.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strain-rate-dependent dislocation-martensite interactions in Fe-Mn-Al-Nb medium manganese steel via discrete dislocation dynamics modeling 基于离散位错动力学模型的Fe-Mn-Al-Nb中锰钢中应变速率相关位错-马氏体相互作用

IF 7.9 2区材料科学

Materials & Design Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.matdes.2026.115586

Ning Guo , Xinping Ji , Bingtao Tang , Jilai Wang

{"title":"Strain-rate-dependent dislocation-martensite interactions in Fe-Mn-Al-Nb medium manganese steel via discrete dislocation dynamics modeling","authors":"Ning Guo , Xinping Ji , Bingtao Tang , Jilai Wang","doi":"10.1016/j.matdes.2026.115586","DOIUrl":"10.1016/j.matdes.2026.115586","url":null,"abstract":"<div><div>Medium manganese steels (MMnS) exhibit exceptional strength-ductility synergy due to the well-known transformation induced plasticity (TRIP) effects, making it a prime candidate for automotive lightweighting and safety–critical structures. However, the strain-rate-dependent dislocation-martensite interactions governing its strain hardening and plasticity remain incompletely understood, particularly regarding dynamic loading conditions. To address this gap, this study employs an integrated experimental-computational approach by combining dynamic tensile tests (1000–3000 s<sup>−1</sup>) via split Hopkinson bar apparatus, microstructural characterization, and a novel 3D discrete dislocation dynamics (DDD) model simulating dislocation evolution in austenite–martensite systems. Key findings demonstrate that elevated strain rates enhance yield strength by 12.7 %, primarily through intensified dislocation density and dislocation cell formation, though this concurrently exacerbates strain localization. Furthermore, closer dislocation-martensite proximity (300–1200 nm) significantly increases the critical stress required for dislocation accumulation ahead of martensite. Notably, successful bypassing triggers abrupt macroscopic stress drops followed by rapid dislocation proliferation. Critically, martensite promotes dislocation accumulation and induces secondary hardening; its 45° orientation activates distinct slip systems that accumulate higher dislocation densities, yielding the maximum strength. These insights elucidate dislocation-mediated strengthening under dynamic loading, establishing a microstructure-guided framework for designing advanced high-performance steels.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"263 ","pages":"Article 115586"},"PeriodicalIF":7.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of bimodal heterostructure features on strength-ductility trade-off breaking in Inconel 718 Ni-based superalloy 双峰异质组织特征对Inconel 718镍基高温合金强度-塑性平衡断裂的影响

IF 7.9 2区材料科学

Materials & Design Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.matdes.2026.115587

Zihao Jiang , Nanping Yue , Junpeng Ren , Lei Zhou , Yingfei Guo , Pingwei Xu , Fei Zhao , Longxiang Wang , Yonghai Ren , Zhiguo Dong , Yu Liang

{"title":"Effect of bimodal heterostructure features on strength-ductility trade-off breaking in Inconel 718 Ni-based superalloy","authors":"Zihao Jiang , Nanping Yue , Junpeng Ren , Lei Zhou , Yingfei Guo , Pingwei Xu , Fei Zhao , Longxiang Wang , Yonghai Ren , Zhiguo Dong , Yu Liang","doi":"10.1016/j.matdes.2026.115587","DOIUrl":"10.1016/j.matdes.2026.115587","url":null,"abstract":"<div><div>A bimodal heterostructure with alternating δ phase-rich fine-grained (FG) and δ phase-lean coarse-grained (CG) regions was constructed in Inconel 718 via the selective precipitation of the δ phase, enabled by controlled Nb content and heat treatment. Compared to the homogeneous counterpart, the optimal heterostructure achieves a significant enhancement in yield strength (222 MPa increase) and ultimate tensile strength (213 MPa increase) while maintaining good ductility. Multiscale characterization revealed an effective heterointerface influence range of ∼22 μm. CG regions beyond this effective range exhibits quasi-homogeneous deformation, thereby impeding dynamic strain partitioning and HDI strengthening that arise from the accumulation of geometrically necessary dislocations (GNDs). Notably, a stress equilibrium mechanism is identified. When the coarse grain size is moderate and the proportion of FG regions is sufficiently high, the forward stress generated by dislocation pile-ups can be effectively borne by the FG regions and transformed into beneficial work hardening. Conversely, under the condition of excessively large coarse grains and a low FG regions fraction, the local stress at the heterointerface is likely to exceed the accommodation limit, triggering premature microcrack initiation in FG regions and a loss of the synergy. This work provides a strategy for designing heterostructure via second-phase engineering.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"263 ","pages":"Article 115587"},"PeriodicalIF":7.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mechanism of natural age-strengthening of grey cast iron: PEC-ageing 灰口铸铁的自然时效强化机制：pec时效

IF 7.9 2区材料科学

Materials & Design Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI: 10.1016/j.matdes.2026.115536

Juan Manuel Bello Bermejo , Jesús Carrero Robles , Huaiyu Chen , Megan O. Hill Landberg , Jesper Wallentin , Johan Hektor , Lena Magnusson Åberg , Henrik Borgström , Filip Lenrick

{"title":"The mechanism of natural age-strengthening of grey cast iron: PEC-ageing","authors":"Juan Manuel Bello Bermejo , Jesús Carrero Robles , Huaiyu Chen , Megan O. Hill Landberg , Jesper Wallentin , Johan Hektor , Lena Magnusson Åberg , Henrik Borgström , Filip Lenrick","doi":"10.1016/j.matdes.2026.115536","DOIUrl":"10.1016/j.matdes.2026.115536","url":null,"abstract":"<div><div>In this work we introduce the concept of natural ageing via precipitation arising from eutectic cell structure (PEC-ageing). Natural age-strengthening in grey cast iron at room temperature is long recognised yet still poorly understood, despite its beneficial effect on tensile strength and machinability. We investigate its underlying mechanisms by comparing fresh and naturally aged industrial grey cast iron using high-resolution synchrotron Wide-Angle X-ray Scattering (WAXS), complemented by scanning electron microscopy and X-ray energy-dispersive spectroscopy. A strict sample-preparation process was designed to minimize artificial ageing and X-ray attenuation artefacts. We present direct experimental evidence of an X-ray diffraction peak that forms upon natural ageing in grey cast iron. Based on its position in reciprocal space, a plausible candidate for this peak is the iron nitride phase <span><math><mrow><mrow><mi>Fe</mi></mrow><msub><mrow><mrow><mphantom><mi>X</mi></mphantom></mrow></mrow><mrow><mrow><mn>4</mn></mrow></mrow></msub><mrow><mi>N</mi></mrow></mrow></math></span>. Spatially resolved analysis further shows that this phase is strongly localised along eutectic cell boundaries, supporting a nitride-related, boundary-mediated precipitation mechanism (PEC-ageing) as the main driver of the ageing phenomenon. These results provide a spatially resolved description of natural ageing in grey cast iron, establish WAXS as a powerful tool to track ageing-related changes in the bulk, and highlight that logistics and sample preparation remain the main practical challenges for future in-situ studies.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"263 ","pages":"Article 115536"},"PeriodicalIF":7.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of process parameters on interlayer interface mechanical properties of 3D printing fiber reinforced concrete 工艺参数对3D打印纤维增强混凝土层间界面力学性能的影响

IF 7.9 2区材料科学

Materials & Design Pub Date : 2026-03-01 Epub Date: 2026-01-26 DOI: 10.1016/j.matdes.2026.115539

Lei Feng , Nuo Chen , Xiao-dong Wen

{"title":"Influence of process parameters on interlayer interface mechanical properties of 3D printing fiber reinforced concrete","authors":"Lei Feng , Nuo Chen , Xiao-dong Wen","doi":"10.1016/j.matdes.2026.115539","DOIUrl":"10.1016/j.matdes.2026.115539","url":null,"abstract":"<div><div>The layer-by-layer deposition in concrete 3D printing creates weak interlayer interfaces, posing risks to structural integrity. This study systematically investigates the effects of printing parameters (layer height, speed, interlayer time intervals) and material composition on interlaminar tensile/shear strength and defect formation mechanisms using an experimental-computational approach. Results demonstrate that mechanical performance inversely correlates with layer height, printing speed, and interlayer intervals: reducing layer height from 15 mm to 5 mm elevates tensile strength by 186.85 %, while decreasing printing speed from 50 mm/s to 30 mm/s improves interlaminar tensile strength by 50.7 %. Continuous printing enhances interlaminar tensile and shear strengths by 77.18 % and 45.96 %, respectively, compared to 24-hour delayed printing. Microstructural analysis identifies crack width expansion as the primary cause of interfacial weakening. A mechanics-driven numerical model was established to quantify process-property relationships, predicting interlaminar tensile/shear forces with <5 % deviation from experimental measurements. Validation confirmed that the model can integrate and push out key parameters (layer height: 13–26 mm; Speed: 22–92 mm/s) for optimal bonding in line with industry specifications. This work provides a predictive framework for optimizing 3D-printed concrete structures by balancing process efficiency and interfacial durability, advancing the design of robust additive-manufactured construction components.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"263 ","pages":"Article 115539"},"PeriodicalIF":7.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0