{"title":"Bi-Modal Synapse Based on a Short-Channel Ferroelectric van der Waals Heterostructure.","authors":"Ankita Ram,Stephane Fusil,Shehr Bano Masood,Neeraj Kumar Rajak,Gaurab Samanta,Mohamed Soliman,Takashi Taniguchi,Kenji Watanabe,Bernard Doudin,Abdelkarim Ouerghi,Alexei Gruverman,Jean-Francois Dayen","doi":"10.1021/acsami.5c16593","DOIUrl":"https://doi.org/10.1021/acsami.5c16593","url":null,"abstract":"The growing demand for energy-efficient and -adaptive computing drives research into neuromorphic architectures. Van der Waals (vdW) ferroelectric field-effect transistors offer nonvolatile polarization control and a highly tunable semiconductor channel, enabling multilevel states and making them promising for brain-inspired electronics. Here, we present a reconfigurable bimodal ferroelectric synapse based on the CuInP2S6/hBN/WSe2 vdW heterostructure, extending beyond conventional single-modal synaptic devices by introducing added functionality. Transport measurements and piezoresponse force microscopy reveal precise electrical control over the ferroelectric domain landscape, enabling continuous tuning of WSe2 channel conductance and its threshold voltage. Crucially, the ambipolar nature of WSe2 allows for real-time switching between excitatory and inhibitory synaptic behaviors, mimicking multimodal neurotransmission observed in the human brain. Moreover, the bimodal synapse is demonstrated at channel lengths down to 50 nm, venturing into previously uncharted territory for ferroelectric vdW synapses. Neural network simulations incorporating our device show excellent learning performance for both synaptic modes, highlighting its potential for next-generation neuromorphic computing. This work expands the functional and scaling capabilities of vdW ferroelectric technology, highlighting its potential for next-generation artificial intelligence electronics.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"105 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jörg Schörmann,Mario F Zscherp,Silas A Jentsch,Martin Becker,Markus Stein,Florian Meierhofer,Christoph Margenfeld,Fabian Winkler,Andreas Beyer,Kerstin Volz,Andreas Waag,Sangam Chatterjee
{"title":"AlScN Pseudosubstrates for High Indium Content InGaN Alloy Epitaxy.","authors":"Jörg Schörmann,Mario F Zscherp,Silas A Jentsch,Martin Becker,Markus Stein,Florian Meierhofer,Christoph Margenfeld,Fabian Winkler,Andreas Beyer,Kerstin Volz,Andreas Waag,Sangam Chatterjee","doi":"10.1021/acsami.5c14209","DOIUrl":"https://doi.org/10.1021/acsami.5c14209","url":null,"abstract":"Nitride-based semiconductors are vital for efficient optoelectronic devices in the ultraviolet to green spectral range. However, producing red-emitting InGaN micro-LEDs is challenging due to lattice mismatch with traditional GaN substrates. This mismatch causes strain relaxation, compositional gradients, and defects in high-indium-content InGaN films. These issues severely limit device efficiency, and the potential of alternative substrates to address these challenges is not fully explored. Here, we show that Al1-xScxN pseudosubstrates with adjustable lattice parameters greatly improve lattice matching of InGaN. Using plasma-assisted molecular beam epitaxy, we grow 120 nm-thick, phase-pure Al1-xScxN layers (0.1 < xSc < 0.2). This enables high-quality deposition of In0.28Ga0.72N layers and a uniform indium distribution compared to growth directly on GaN. AlScN-supported films exhibit no compositional pulling effect common for conventional substrates. This uniformity is confirmed by room-temperature photoluminescence, showing a narrow emission at 538 nm. Our results demonstrate that AlScN pseudosubstrates are promising for future integrated red micro-LED devices.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"1 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Muñoz-Gil,Celia Castillo-Blas,Dawid Krystian Feler,Isabel Gómez-Recio,Miguel Tinoco,Ana Querejeta-Fernández,Rodrigo González-Prieto,Felipe Gándara,Romualdo Santos Silva,Pilar Ferrer,Carlos Prieto,Luc Lajaunie,José Luis Martinez-Peña,María Luisa Ruiz-González,José María González-Calbet
{"title":"2D Co-Mo-Hydroxide-Based Multifunctional Material for the Development of H2-Based Clean Energy Technologies.","authors":"Daniel Muñoz-Gil,Celia Castillo-Blas,Dawid Krystian Feler,Isabel Gómez-Recio,Miguel Tinoco,Ana Querejeta-Fernández,Rodrigo González-Prieto,Felipe Gándara,Romualdo Santos Silva,Pilar Ferrer,Carlos Prieto,Luc Lajaunie,José Luis Martinez-Peña,María Luisa Ruiz-González,José María González-Calbet","doi":"10.1002/adma.202512458","DOIUrl":"https://doi.org/10.1002/adma.202512458","url":null,"abstract":"Layered double hydroxides (LDH) based on transition metals are highly flexible in tailoring their dimensionality, lattice, and electronic structures, making them promising candidates as multifunctional 2D materials for the development of clean energy technologies and boosting the use of hydrogen as an energy vector. In this paper, strategic anion substitution in cobalt LDH is an appealing strategy to produce a material with two-fold functionality, electrochemical and magnetocaloric response, offering a sustainable alternative to existing electrocatalysts and cryogenic refrigerants. It is unambiguously demonstrated that (poly)oxomolybdate-based specimens interleave in Co LDH nanosheets up to a Co:Mo = 1:0.4 ratio, leading to an interstratified material. This intercalation greatly benefits the kinetics of the oxygen evolution reaction for H2 production, boosting the catalytic sites due to the expansion of the interlayer space, induced by the bulky molybdates which also partially modify the Co oxidation state of αCo(OH)2 nanolayers, favoring charge transfer. In parallel, the interleaved Mo species strengthen superexchange interactions compared with pristine α-Co(OH)2, effectively adjusting the operating temperature toward the liquid hydrogen range (2030 K). This specific temperature range allows to fill a critical gap in magnetocaloric materials, as few systems can simultaneously achieve both large magnetic entropy changes and structural stability.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"47 1","pages":"e12458"},"PeriodicalIF":29.4,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Machine Learning-Driven Grayscale Digital Light Processing for Mechanically Robust 3D-Printed Gradient Materials (Adv. Mater. 42/2025)","authors":"Jisoo Nam, Boxin Chen, Miso Kim","doi":"10.1002/adma.70839","DOIUrl":"https://doi.org/10.1002/adma.70839","url":null,"abstract":"<p><b>Machine Learning-Driven Grayscale Digital Light Processing</b></p><p>In their Research Article (DOI: 10.1002/adma.202504075), Jisoo Nam, Boxin Chen, and Miso Kim combine machine learning-driven optimization with grayscale digital light processing to create 3D-printed gradient materials with tailored mechanical properties. Pixel-level light control enables seamless stiffness modulation, improving stress distribution, toughness, and fatigue life. The cover image illustrates the translation of digital design data into architected gradients for durable, high-performance impact absorbers and protective structures.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 42","pages":""},"PeriodicalIF":26.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adma.70839","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Conglong Yuan, Huixian Liu, Yuxing Zhan, Xuan Liu, Yuqi Tang, Honglong Hu, Zhi-Gang Zheng, Quan Li
{"title":"Electro-Thermo Cooperative Responsiveness of Cholesteric Heliconical Photonics Architectures Featuring Adaptative Sensitivity (Adv. Mater. 42/2025)","authors":"Conglong Yuan, Huixian Liu, Yuxing Zhan, Xuan Liu, Yuqi Tang, Honglong Hu, Zhi-Gang Zheng, Quan Li","doi":"10.1002/adma.70842","DOIUrl":"https://doi.org/10.1002/adma.70842","url":null,"abstract":"<p><b>Electro-Thermal Cooperative Cholesteric Heliconical Architectures</b></p><p>In their Research Article (DOI: 10.1002/adma.202507000), Zhi-Gang Zheng, Quan Li, and co-workers present electro-thermal cooperative cholesteric heliconical photonic architectures that achieve unprecedented control over thermochromic behavior, enabling linear and programmable temperature sensitivity, full-visible range structural color modulation, and customizable operating ranges. By harnessing these advanced capabilities into intelligent sensing and high-dimensional information encryption, this study paves the way for multi-functional soft matter systems and next-generation photonic technologies.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 42","pages":""},"PeriodicalIF":26.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adma.70842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Induced Pluripotent Stem Cell-Derived Extracellular Vesicles Prevent Neural Stem Cell Senescence to Promote Cognitive Recovery after Traumatic Brain Injury.","authors":"Tiange Chen,Qian Zhang,Liyang Zhang,Ying Ai,Ziyang Chen,Jiacheng Liu,Ganzhi Liu,Xin Chen,Tao Xu,Yuguo Xia,Jinfang Liu","doi":"10.1021/acsnano.5c10672","DOIUrl":"https://doi.org/10.1021/acsnano.5c10672","url":null,"abstract":"Hippocampal neural stem cells (NSCs) have attracted significant attention due to their essential role in maintaining cognitive functions, such as memory and spatial orientation through neurogenesis. Cognitive impairment is a common and debilitating complication of traumatic brain injury (TBI), yet its underlying mechanisms remain poorly understood and effective clinical interventions are lacking. In this study, we observed persistent cognitive deficits in a mouse model of TBI, a phenomenon that has been widely documented in previous studies, and importantly, we found that these impairments were closely associated with increased hippocampal NSCs (H-NSCs) senescence. To investigate the cause of NSCs' senescence, we analyzed cerebrospinal fluid samples from TBI patients and hippocampal tissues from TBI mice and identified persistently elevated levels of IL-1β post TBI. In vitro, IL-1β successfully induced NSCs' senescence and suppressed neurogenesis. Induced pluripotent stem cell-derived small extracellular vesicles (iPSC-sEVs) reversed IL-1β-induced senescence and restored neurogenic potential in H-NSCs. In vivo, iPSC-sEVs alleviated cognitive deficits and H-NSC senescence after TBI. Integrated proteomic and NSC cell transcriptomic analyses revealed that the β-catenin/ID2/CDKN2B (p15INK4b) signaling axis plays a critical role in regulating H-NSC senescence, which was further validated through inhibitor experiments. In summary, our findings demonstrate that iPSC-sEVs attenuate NSC senescence and improve cognitive function following TBI via modulation of the β-catenin/ID2/CDKN2B (p15INK4b) axis.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"58 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypoxia-Responsive Thio-Perylene Diimides Delivered via pH-Responsive Polypeptide Nanoparticles: Toward a Combination of NIR Photothermal Therapy and Chemotherapy.","authors":"Yushen Kang,He Ma,Huacheng Yu,Jinpeng Yang,Jiang-Fei Xu,Xi Zhang","doi":"10.1021/acsami.5c19039","DOIUrl":"https://doi.org/10.1021/acsami.5c19039","url":null,"abstract":"Developing responsive therapeutic systems based on the tumor microenvironment is crucial for efficient and specific treatments. However, how to achieve sensitive response and efficient anticancer bioactivity remains a challenge. Here, tumor-responsive polypeptide nanoparticles encapsulating thio-perylene diimides are constructed. Anticancer peptides were released through the hydrolysis of acid-labile amide bonds to induce cell apoptosis, while thio-perylene diimide radical anions with up to 67% NIR photothermal conversion efficiency could be generated through a hypoxia-induced biological reduction process. Thus, this approach enables the development of a dual-response nanomedicine to achieve combinational NIR photothermal therapy and chemotherapy. In the A549 lung cancer cell-derived xenograft model established in BALB/c nude mice, the tumor inhibition rate reached 68.0%. In addition, tumor-responsive polypeptide nanoparticles also possessed excellent biocompatibility. This line of research provides a new method for the construction of highly sensitive tumor microenvironment-responsive therapeutic systems and contributes to the development of comprehensive multimodal treatment approaches.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"2 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NanoscalePub Date : 2025-10-23DOI: 10.1039/d5nr03494a
Xuan Chen,Ting-Ting Guo,Xiang Chen,Hao-Wei Tao,Shuo-Heng Niu,Xiu-Feng Song,Hai-Bo Zeng
{"title":"Boron nitride memristors: from mechanism and device optimization to integrated applications.","authors":"Xuan Chen,Ting-Ting Guo,Xiang Chen,Hao-Wei Tao,Shuo-Heng Niu,Xiu-Feng Song,Hai-Bo Zeng","doi":"10.1039/d5nr03494a","DOIUrl":"https://doi.org/10.1039/d5nr03494a","url":null,"abstract":"The relentless scaling of integrated circuits faces significant bottlenecks in conventional memory technologies. This challenge is primarily attributed to the limitations of the von Neumann architecture and the physical constraints of mainstream memory technologies. Non-volatile memristors offer compelling advantages and excellent scalability. They have an inherent ability to emulate synaptic plasticity for neuromorphic computing. Boron nitride (BN) emerges as a highly promising active layer for memristors due to its superior thermal stability, mechanical strength, chemical inertness, atomically smooth surface, and compatibility with complementary metal-oxide-semiconductor (CMOS) processing. This review systematically examines recent advancements in BN memristors, including resistive switching mechanisms, synthesis methods, and the effect of electrode contacts and device architectures on performance. It also highlights key application domains such as memory devices, neuromorphic computing and RF switches. Finally, the review identifies current challenges, including achieving large-area uniformity, precisely controlling filament dynamics, enhancing endurance/retention, and understanding complex switching behaviors. This work provides perspectives on future research directions focused on optimizing material engineering, enabling 3D integration, realizing multi-level storage, and exploring novel heterostructures to inspire the full potential of BN memristors for next-generation electronics.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"69 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Activable Photosensitizer for Sunshine-Driven Photodynamic Therapy Against Multiple-Antibiotic-Resistant Bacteria by Exploiting Macrophage Chemotaxis.","authors":"Zehui Wang,Lai Wang,Lin Zhou,Yi Xiao,Xinfu Zhang","doi":"10.1002/adma.202508232","DOIUrl":"https://doi.org/10.1002/adma.202508232","url":null,"abstract":"Aiming to improve photodynamic therapy (PDT) safety and specificity at the in vivo level, a new concept is proposed by combining the chemotaxis and circulating ability of macrophages with the controllable therapeutic efficiency of PDT. Moreover, an irradiation strategy is utilized of sunbathing to conduct PDT. Specifically, an inflammation-activable photosensitizer (Lyso710A) based on NIR BODIPY is designed and loaded it into macrophages. These \"armed\" macrophages are then transferred into the infected host to capture bacteria and transport them to the surface of the skin through blood circulation, where sunlight can penetrate. Upon capturing bacteria, the photodynamic effect of Lyso710A is turned on by the macrophage's endogenous hypochlorous acid (HClO). When these macrophages reach the epidermis, the bacteria are eradicated by the photodynamic effect of the activated photosensitizer during exposure to sunlight. Furthermore, this strategy demonstrates promising therapeutic efficacy in two animal models (mouse and rabbit) with systemic bacterial infection, using a low photosensitizer dose of 0.14 mg Kg-1 in animals. This work demonstrates an intelligent and promising approach to breaking the routine of PDT and, for the first time, executing PDT for deep-tissue bacterial infection simply by bathing in the sunshine.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"32 1","pages":"e08232"},"PeriodicalIF":29.4,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From Structure to Performance: Exploring MOF-Based Electrolytes for Enhanced Sodium-Ion Battery Conductivity.","authors":"Pratheep Panneerselvam,Seul-Yi Lee,Soo-Jin Park","doi":"10.1002/adma.202514254","DOIUrl":"https://doi.org/10.1002/adma.202514254","url":null,"abstract":"Energy storage systems (ESSs) are recognized as vital for sustaining industrial growth and the rising demand for portable and large-scale applications. Sodium-ion batteries (SIBs), using abundant sodium, offer an alternative to costly lithium-ion batteries (LIBs) but face challenges with lower energy density, slow ion transport, and limited cycle stability. This review critically examines metal-organic frameworks (MOFs) as next-generation electrolytes capable of addressing these challenges by following these mechanisms. High porosity and ordered channels (6-12 Å) facilitate uniform Na+ diffusion and reduce activation barriers from 1.23 to 0.36 eV, directly improving power density. Tunable functional groups with strategic electronegativity enable selective ion transport and dendrite suppression, thereby enhancing cycle stability. Framework versatility allows integration with polymers and ionic liquids, yielding ionic conductivities above 10-4 S cm-1 and boosting energy density. Charge transport occurs via both through-bond and through-space pathways, with the latter achieving up to 43-fold improvements in diffusion coefficients. By consolidating these findings, the review establishes a systematic structure performance framework: pore geometry governs ionic conductivity, functional groups control ion selectivity, and framework flexibility dictates mechanical stability during cycling. This MOF electrolytes development from empirical exploration to rational design, providing guiding principles and future directions for scalable, safe, and high-performance SIBs.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"15 1","pages":"e14254"},"PeriodicalIF":29.4,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}