IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-31 DOI: 10.1016/j.nantod.2025.102819

Miao Feng , Stefan Werner , Bing Qi , Jinrui Li , Florian Schulz , Wolfgang J. Parak

{"title":"Quantification of optimizing cellular uptake and excretion of nanoparticles by aggregation and de-aggregation mediated size changes","authors":"Miao Feng , Stefan Werner , Bing Qi , Jinrui Li , Florian Schulz , Wolfgang J. Parak","doi":"10.1016/j.nantod.2025.102819","DOIUrl":"10.1016/j.nantod.2025.102819","url":null,"abstract":"<div><div>Gold nanoclusters of around 1.7 nm diameter were encapsulated in a matrix of the biodegradable polymer poly-L-arginine (PLAG), leading to nanoparticles (NPs) of around 70 nm diameter. It was shown that in order to achieve the same amount of endocytosed Au after 24 h exposure of HeLa cells to the NPs, for the encapsulated nanoclusters around 3 times less Au needed to be added to the cells, minimizing the necessary exposure concentration. On the other hand, due to the degradability of the PLAG, the intracellular Au could be exocytosed by around 3.5 times faster than for non-degradable Au NPs of similar initial size. This study thus quantified the effect of size-variable NPs on endo- and exocytosis. Aggregation of small NPs to bigger NPs in biodegradable matrices allows for improved endocytosis. De-aggregation of endocytosed aggregated NPs upon degradation of the biodegradable matrix allows for improved exocytosis, which is an important prerequisite for NPs clearance from cells, avoiding long-term toxicity.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102819"},"PeriodicalIF":13.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting the morphology-driven pathogenicity of nanofibers through proteomic profiling 通过蛋白质组学分析预测纳米纤维的形态驱动致病性

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-29 DOI: 10.1016/j.nantod.2025.102812

Tobias Stobernack , Antje Vennemann , Dirk Broßell , Oliver Gräb , Mario Pink , Andrea Haase , Martin Wiemann , Verónica I. Dumit

{"title":"Predicting the morphology-driven pathogenicity of nanofibers through proteomic profiling","authors":"Tobias Stobernack , Antje Vennemann , Dirk Broßell , Oliver Gräb , Mario Pink , Andrea Haase , Martin Wiemann , Verónica I. Dumit","doi":"10.1016/j.nantod.2025.102812","DOIUrl":"10.1016/j.nantod.2025.102812","url":null,"abstract":"<div><div>The shape and durability of inhalable fibers is connected with their potential to cause lung cancer. Especially toxicological effects of nanofibers and their derivatives are still incompletely understood. Currently, their safety evaluation is performed under <em>in vivo</em> settings. However, as nanofiber applications continue to expand, alternative approaches are urgently needed that align with the 3 R principles (Replacement, Reduction, Refinement). To this end, silicon carbide (SiC) and titanium dioxide (TiO<sub>2</sub>) nanofibers as well as their ground fragments were tested in the NR8383 alveolar macrophage assay. Intact nanofibers induced dose-dependent cytotoxicity, oxidative stress, and the release of pro-inflammatory cytokines, while their ground counterparts elicited minimal effects. The subsequent proteomic profiling of cells exposed to a sub-cytotoxic nanofiber concentration revealed significant alterations in the levels of 32 % (SiC) and 8 % (TiO<sub>2</sub>) of all detected proteins compared to untreated cells. Besides protein modifications induced by oxidative stress, key alterations comprised protein clusters attributed to inflammation (n<sub>proteins</sub>=9), vesicular trafficking (n = 22), metabolic changes (n = 32) and apoptosis (n = 5). Cells treated with equal amounts of ground nanofibers exhibited only negligible changes, highlighting the morphology-driven nature of the effects. Finally, a set of 58 proteins are proposed as a proteomic fingerprint of nanofiber-related toxicity at the cellular level. Overall, the study substantiates fiber morphology-driven effects of nanofibers in alveolar macrophages and outlines concrete protein biomarkers to describe nanofiber pathogenicity along with underlying mechanisms. This work contributes to the development of a robust <em>in vitro</em> testing strategy required for the Safe-and-Sustainable-by-Design demand of the European Commission.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102812"},"PeriodicalIF":13.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered nanoparticle transformations: Rethinking toxicity in water 工程纳米颗粒转化：重新思考水中的毒性

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-28 DOI: 10.1016/j.nantod.2025.102804

Mikołaj Feculak , Susana Loureiro , Jason C. White , Baoshan Xing , Kevin C.-W. Wu , Mohamed Salah Sheteiwy , Yanzheng Gao , Patryk Oleszczuk , Izabela Jośko

{"title":"Engineered nanoparticle transformations: Rethinking toxicity in water","authors":"Mikołaj Feculak , Susana Loureiro , Jason C. White , Baoshan Xing , Kevin C.-W. Wu , Mohamed Salah Sheteiwy , Yanzheng Gao , Patryk Oleszczuk , Izabela Jośko","doi":"10.1016/j.nantod.2025.102804","DOIUrl":"10.1016/j.nantod.2025.102804","url":null,"abstract":"<div><div>The burgeoning production and utilization of engineered nanoparticles (ENPs) in recent years has precipitated the intentional and inadvertent discharge of ENPs into the environment, where undergo different transformations. Extensive research has investigated the mechanisms underlying the environmental transformations of metal-based ENPs, with a focus on alterations in the properties of their transformation products. It is widely recognized that ENP-biota interactions are influenced by various ENP characteristics, such as size, shape, surface area, chemical composition, surface charge, and chemistry. As a result of transformations, changes in ENP properties are anticipated to affect biotic interactions, including cellular recognition and trafficking, thus impacting organismal responses. This hypothesis has only recently been subjected to experimental scrutiny, mainly within simplified ENP-organism systems. Major studies indicate that the acute toxicity of transformed ENPs is largely driven by the rate and yield of metal ion release, similar to pristine ENPs. However, when transformations reduce ENP dissolution, they may enhance environmental persistence, rendering other toxicity mechanisms more significant. We meticulously examine available data on the toxicity of various transformed ENPs, aiming to systematically assess the actual responses of aquatic biota concerning altered ENP properties and differing environmental factors. In this context, we highlight scenarios involving multiple ENP transformations and specific local environmental modifications. These research directions warrant further exploration, especially under real-world conditions. Such efforts will expand the database, which, through the application of modern machine learning and artificial intelligence tools, can aid in predicting the fate of ENPs released from the increasing array of nano-products.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102804"},"PeriodicalIF":13.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breathable palladium hydride hydrogels mediated “head and tail” co-blocking HMGB1-RAGE axis strategy for diabetic foot ulcer treatment 透气性氢化钯水凝胶介导的“头尾”共阻断HMGB1-RAGE轴策略治疗糖尿病足溃疡

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-28 DOI: 10.1016/j.nantod.2025.102815

Weidi Wang , Xueling Liu , Jiali Xiao , Yunning Zhang , Yu Hao , Ruidong Hou , Liang Fang , Qing You , Yilin Song

{"title":"Breathable palladium hydride hydrogels mediated “head and tail” co-blocking HMGB1-RAGE axis strategy for diabetic foot ulcer treatment","authors":"Weidi Wang , Xueling Liu , Jiali Xiao , Yunning Zhang , Yu Hao , Ruidong Hou , Liang Fang , Qing You , Yilin Song","doi":"10.1016/j.nantod.2025.102815","DOIUrl":"10.1016/j.nantod.2025.102815","url":null,"abstract":"<div><div>Diabetes patients suffer from severe chronic consequences known as diabetic foot ulcers (DFUs), for which there are no particular therapy options. The inflammatory and oxidative microenvironments in DFUs stimulate the secretion of high mobility group box-1 (HMGB1), which binds with the receptor of advanced glycation endproducts (RAGE), causing inflammatory cascade reactions and immune microenvironment (IME) disorder, further exacerbating DFUs damage. Strategies targeting the HMGB1-RAGE axis to end this vicious loop are still lacking. This study proposes a novel strategy based on “breathable hydrogels” to achieve HMGB1-RAGE axis “head and tail” co-blocking to regulate the IME for DFUs treatments. Specifically, with palladium hydride (PdH) nanocubes as the functional structure, a hydrogel dressing was prepared from a double cross-linking network of biocompatible alginate and polyacrylamide and modified with trehalose as the network-repairing agent. Mechanistically, the obtained hydrogels can “inhale” the excess accumulated reactive oxygen species, inhibiting HMGB1 secretion, the “head” of the HMGB1-RAGE axis. Meanwhile, H<sub>2</sub> “exhaled” from the hydrogels can suppress the expression of intracellular RAGE, thus blocking the HMGB1-RAGE axis and breaking the vicious cycle. The proposed “head and tail” co-blocking strategy based on “breathable hydrogels” offers a highly efficient, safe, and facile therapeutic protocol for DFUs.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102815"},"PeriodicalIF":13.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogel empowered extracellular vesicles isolation, detection, and delivery 水凝胶增强了细胞外囊泡的分离、检测和递送

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-28 DOI: 10.1016/j.nantod.2025.102817

Yuting Li , Zhinan Liu , Zelin Zheng , Liyi Bai , Wen Wang , Li Min , Honggang Hu , Yejiao Shi

{"title":"Hydrogel empowered extracellular vesicles isolation, detection, and delivery","authors":"Yuting Li , Zhinan Liu , Zelin Zheng , Liyi Bai , Wen Wang , Li Min , Honggang Hu , Yejiao Shi","doi":"10.1016/j.nantod.2025.102817","DOIUrl":"10.1016/j.nantod.2025.102817","url":null,"abstract":"<div><div>Extracellular vesicles (EVs), bilayered phospholipid structures capable of transporting diverse biomolecules from parent cells to neighboring cells or distant organs, exhibit remarkable potential in disease diagnosis and treatment. However, their efficient isolation, accurate detection, and controlled delivery have been greatly hindered by their low density in body fluid, low concentration of containing biomarkers, as well as rapid circulation rate <em>in vivo</em>, respectively. Over the past decade, an expanding number of studies have found that the three-dimensional porous hydrogels with adjustable structures, customizable functions, as well as desirable biocompatibility and biodegradability could provide a powerful platform for tackling these obstacles. Herein, this review summarized the recent progress in utilizing natural and synthetic hydrogels to assist in the isolation, detection, and delivery of EVs, with an emphasis on the relevant properties of hydrogels. In addition, the associated challenges were considered and the emerging possible opportunities were discussed. The comprehensive understanding of the hydrogel empowered isolation, detection, and delivery of EVs would promote the future development of EV-based integrating platforms for disease diagnosis and treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102817"},"PeriodicalIF":13.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A branched DNA nanoplatform-based mRNA vaccine for efficient immunotherapy in vivo 基于分支DNA纳米平台的mRNA疫苗在体内的有效免疫治疗

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-27 DOI: 10.1016/j.nantod.2025.102818

Changping Yang , Jing Fan , Hanyin Zhu , Huarui Liu , Xintong Li , Dandan Li , Hong Wang , Jianbing Liu , Baoquan Ding

{"title":"A branched DNA nanoplatform-based mRNA vaccine for efficient immunotherapy in vivo","authors":"Changping Yang , Jing Fan , Hanyin Zhu , Huarui Liu , Xintong Li , Dandan Li , Hong Wang , Jianbing Liu , Baoquan Ding","doi":"10.1016/j.nantod.2025.102818","DOIUrl":"10.1016/j.nantod.2025.102818","url":null,"abstract":"<div><div>Immunotherapy based on mRNA vaccine has been widely developed for treatments of various diseases. Herein, we report a branched DNA nanoplatform-based mRNA vaccine for efficient immunotherapy <em>in vivo</em>. In our design, two branched DNA structures are employed as the connectors to co-assemble with disulfide bonds-involved RNA linker. In this branched DNA nanoplatform, the mRNA with 5’ cap and 3’ poly A can be efficiently loaded by RNA hybridization. Meanwhile, the adjuvants (CpG) and lipids (DOPE) can be site-specifically included through DNA hybridization. After co-assembly, the nanoparticle with lipid seeds on the surface can function as a template for lipid growth. The mRNA-loaded and lipids-coated DNA nanoparticle can achieve an efficient cellular uptake and subsequent stimuli-responsive drug release for successful protein expression. Finally, the tumor antigen-encoded mRNA vaccine can elicit a pronounced immunotherapy for tumor inhibition <em>in vivo</em>. This rationally developed branched DNA nanoplatform-based mRNA vaccine presents a new avenue for the development of immunotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102818"},"PeriodicalIF":13.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic metal-phenolic network-coated elastin-like polypeptide micelles as an immunogenic cell death inducer for orthotopic glioma sonodynamic-chemodynamic-immune therapy 仿生金属-酚醛网络包覆弹性蛋白样多肽胶束作为原位胶质瘤声动力学-化学动力学-免疫治疗的免疫原性细胞死亡诱导剂

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-27 DOI: 10.1016/j.nantod.2025.102810

Zhiqiang Wang , Yunqi Guo , Gaoming Li , Honghua Guo , Yanying Li , Jinxia Wang , Kangan Li , Serge Mignani , Mingwu Shen , Elisabeth Garanger , Sébastien Lecommandoux , Xiangyang Shi

{"title":"Biomimetic metal-phenolic network-coated elastin-like polypeptide micelles as an immunogenic cell death inducer for orthotopic glioma sonodynamic-chemodynamic-immune therapy","authors":"Zhiqiang Wang , Yunqi Guo , Gaoming Li , Honghua Guo , Yanying Li , Jinxia Wang , Kangan Li , Serge Mignani , Mingwu Shen , Elisabeth Garanger , Sébastien Lecommandoux , Xiangyang Shi","doi":"10.1016/j.nantod.2025.102810","DOIUrl":"10.1016/j.nantod.2025.102810","url":null,"abstract":"<div><div>Development of a theranostic nanomedicine to tackle orthotopic glioma remains to be challenging due to the difficulties of blood-brain barrier crossing and integration of different theranostic modalities. Herein, we report the design of biomimetic macrophage membrane (MM)-camouflaged metal-phenolic network (MPN)-coated micelles formed by amphiphilic elastin-like polypeptide (ELP)-chlorin e6 (Ce6) conjugates. We show that the MPN formed by assembly of Mn(II) and tannic acid (for short, TM) enables stable coating of the micelles, and the prepared Ce6-ELP@TM/MM exhibits good water dispersibility with a mean size of 67.8 nm. Under the tumor microenvironment condition, the Ce6-ELP@TM/MM could fast release Mn<sup>2 +</sup> to generate reactive oxygen species (ROS) and facilitate Ce6 (a sonosensitizer) to generate singlet oxygen upon ultrasound irradiation, thereby killing cancer cells to induce immunogenic cell death (ICD) through chemodynamic/sonodynamic therapy. Moreover, the ROS-caused DNA damage could combine with Mn<sup>2+</sup> to activate the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway of cancer cells, thus synergizing ICD to trigger enhanced antitumor immune responses to tackle an orthotopic mouse glioma model thanks to the MM-rendered BBB crossing and Mn<sup>2+</sup>-facilitated magnetic resonance imaging. The developed Ce6-ELP@TM/MM could be used as an ICD inducer to facilitate sonodynamic/chemodynamic/immune therapy of glioma or other tumor types.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102810"},"PeriodicalIF":13.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144137757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering hydroxyapatite nanocrystals for cancer nanomedicine through ion substitution: Advances and prospects 离子取代工程羟基磷灰石纳米晶体用于肿瘤纳米药物：进展与展望

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-27 DOI: 10.1016/j.nantod.2025.102816

Gerardo Martin Quindoza III , Takuma Watanabe , Hayato Laurence Mizuno , Vincent Irawan , Yasutaka Anraku , Toshiyuki Ikoma

{"title":"Engineering hydroxyapatite nanocrystals for cancer nanomedicine through ion substitution: Advances and prospects","authors":"Gerardo Martin Quindoza III , Takuma Watanabe , Hayato Laurence Mizuno , Vincent Irawan , Yasutaka Anraku , Toshiyuki Ikoma","doi":"10.1016/j.nantod.2025.102816","DOIUrl":"10.1016/j.nantod.2025.102816","url":null,"abstract":"<div><div>Cancer nanomedicine bridges cancer biology and nanotechnology to enhance diagnostic accuracy and therapeutic efficacy across various cancer modalities, ultimately aiming to improve patient outcomes and survival. Numerous nanomaterials have been explored for cancer nanomedicine; however, most suffer from systemic toxicity and severe side effects. Recently, hydroxyapatite (HAp), the primary inorganic component of bones and teeth, has emerged as a promising nanoplatform for cancer diagnosis and treatment, owing to its inherent biocompatibility and excellent biodistribution. Moreover, its capacity for ion substitutions has further expanded its potential, enhancing their existing properties and introducing new functionalities that are beneficial for cancer nanomedicine. With the growing interest in ionic substituted HAp nanocrystals, summarizing significant findings and mapping out the field’s current progress is imperative. This review examines recent literature on their applications in cancer diagnostics and therapeutics, as well as in theranostics. Key advancements were identified and outlined, and insights into prospective opportunities to guide future research were explored. This review highlights the immense potential of ionic substituted HAp nanosystems as a versatile and promising platform, paving the way for the development of safer and more effective nanomedicine strategies.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102816"},"PeriodicalIF":13.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing intranasally administered electro-responsive nanodrugs for rapid epilepsy treatment 开发鼻内给药的电反应纳米药物用于快速治疗癫痫

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-26 DOI: 10.1016/j.nantod.2025.102808

Wei Shu , Yue Jiang , Shijin Li , Jian Li , Xueting Pan , Changyong Wang , Hai Wang , Tao Yu

{"title":"Developing intranasally administered electro-responsive nanodrugs for rapid epilepsy treatment","authors":"Wei Shu , Yue Jiang , Shijin Li , Jian Li , Xueting Pan , Changyong Wang , Hai Wang , Tao Yu","doi":"10.1016/j.nantod.2025.102808","DOIUrl":"10.1016/j.nantod.2025.102808","url":null,"abstract":"<div><div>Epilepsy is a prevalent neurological disorder, with antiepileptic drugs serving as the cornerstone of clinical treatment. However, oral antiepileptic drugs are limited by issues such as low absorption rates, poor bioavailability, and significant toxic side effects. Although nanodrug delivery systems have shown considerable promise in improving drug efficacy and minimizing side effects, they are hindered by biological barriers, particularly the blood-brain barrier (BBB). Intranasal administration of nanodrugs presents a distinct advantage, as it can bypass the BBB and deliver drugs directly to the brain with rapid absorption, making it especially suitable for the treatment of acute epilepsy and status epilepticus. In response to this need, we have designed and synthesized an electrically responsive nanodrug for intranasal delivery that releases the antiepileptic drug in response to abnormal electrical activity during seizures. By capitalizing on the fast brain-targeting capability of intranasal administration, these nanoparticles quickly penetrate the brain and react to the irregular electrical currents generated by seizures, facilitating rapid drug release. This innovative approach provides a timely and effective means of alleviating acute epilepsy and status epilepticus, offering a rapid, targeted strategy for delivering antiepileptic drugs.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102808"},"PeriodicalIF":13.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144137758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Au&WO3 heterojunctions against multidrug-resistant bacteria 抗多重耐药细菌的Au&WO3异质结

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-24 DOI: 10.1016/j.nantod.2025.102813

Pai Zhang , Ruitao Cha , Yanxue Si , Huize Luo , Qianqian Lin , Jiamin Qin , Hao Tang , Fengshan Zhou , Xiaohui Wang , Peng Jiang , Xingyu Jiang

{"title":"Au&WO3 heterojunctions against multidrug-resistant bacteria","authors":"Pai Zhang , Ruitao Cha , Yanxue Si , Huize Luo , Qianqian Lin , Jiamin Qin , Hao Tang , Fengshan Zhou , Xiaohui Wang , Peng Jiang , Xingyu Jiang","doi":"10.1016/j.nantod.2025.102813","DOIUrl":"10.1016/j.nantod.2025.102813","url":null,"abstract":"<div><div>Wound infections caused by multidrug-resistant (MDR) Gram-negative bacteria remain a significant medical challenge. Existing treatments, including antibiotics, antimicrobial peptides, and nanomaterials, are limited by drug resistance and toxicity. It is urgent to develop an effective alternative agent for treatment of infected wound. Here, we synthesized Au&WO<sub>3</sub> heterojunctions <em>via</em> a hydrothermal method and NaBH<sub>4</sub> reduction to address MDR bacterial infections. We characterized the structure of Au&WO<sub>3</sub> heterojunctions by TEM, EDS, and zeta potential. Mechanistically, The enhanced bacterial activity could arise from synergistic effects of membrane disruption by Au nanoparticles and replacement of the molybdenum factor by W<sup>6 +</sup> ions. The Au<sub>1</sub>&WO<sub>3</sub> heterojunction had a minimum inhibitory concentration (MIC) of 12 µg/mL against MDR <em>E. coli</em>, outperforming individual Au nanoparticles and WO<sub>3</sub> nanorods. <em>In vitro</em>, Au<sub>1</sub>&WO<sub>3</sub> induced M2 macrophage polarization, demonstrating strong anti-inflammatory activity. The PG-Au<sub>1</sub>&WO<sub>3</sub> membranes exerted excellent antibacterial and anti-inflammation properties with good biocompatibility, promoting wound healing in MDR <em>E. coli</em>-infected wound models. The Au&WO<sub>3</sub> heterojunctions highlight their potential as a promising wound dressing for MDR infection treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102813"},"PeriodicalIF":13.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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