IF 13.2 1区材料科学

Nano Today Pub Date : 2025-07-14 DOI: 10.1016/j.nantod.2025.102850

Yongcheng Chen , Fang Liu , Haojie Chen , Yue Huang , Yutong Li , Qiao Jin , Jian Ji

{"title":"Self-assembled copper-phenolic nanoparticles for antimicrobial therapy by triggering Fenton reaction and cuproptosis-like bacterial death","authors":"Yongcheng Chen , Fang Liu , Haojie Chen , Yue Huang , Yutong Li , Qiao Jin , Jian Ji","doi":"10.1016/j.nantod.2025.102850","DOIUrl":"10.1016/j.nantod.2025.102850","url":null,"abstract":"<div><div>The increasing prevalence of antibiotic-resistant bacteria poses a significant threat to global health. This study introduces poly(ethylene glycol)-copper-tannic acid nanoparticles (PCT NPs) as a novel therapeutic strategy for treating bacterial infections. PCT NPs, synthesized via self-assembly of Cu²⁺, tannic acid, and poly(ethylene glycol), exhibit pH-responsive release of Cu²⁺, which generates reactive oxygen species (ROS) and depletes glutathione (GSH) in bacterial cells, leading to cuproptosis-like bacterial death. PCT NPs also demonstrate strong adhesion to bacterial surfaces, enhancing their ability to deliver Cu²⁺ directly to bacterial cells. In vitro experiments demonstrate strong bactericidal activity against MRSA and <em>P. aeruginosa</em>. In vivo studies in murine models of skin and lung infections confirm the efficacy of PCT NPs in reducing bacterial load and promoting wound healing. This work highlights PCT NPs as a promising non-antibiotic alternative for combating deep-seated bacterial infections.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102850"},"PeriodicalIF":13.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An integrated therapeutic strategy to enhance cuproptosis through adaptive activation and microenvironment remodeling of prodrug complexes 通过前药复合物的自适应激活和微环境重塑来促进铜形体形成的综合治疗策略

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-07-14 DOI: 10.1016/j.nantod.2025.102853

WeiYe Ren , WeiYi Cheng , Li He , Xiujuan Hong , JingQuan Chen , Yajun Wu , Dandan Bao , Yinghui Wei , Ji-Gang Piao , Zhibing Wu

{"title":"An integrated therapeutic strategy to enhance cuproptosis through adaptive activation and microenvironment remodeling of prodrug complexes","authors":"WeiYe Ren , WeiYi Cheng , Li He , Xiujuan Hong , JingQuan Chen , Yajun Wu , Dandan Bao , Yinghui Wei , Ji-Gang Piao , Zhibing Wu","doi":"10.1016/j.nantod.2025.102853","DOIUrl":"10.1016/j.nantod.2025.102853","url":null,"abstract":"<div><div>Colorectal cancer (CRC) progression is critically driven by its hydrogen sulfide (H₂S)-rich tumor microenvironment, which paradoxically confers chemoresistance by stabilizing redox homeostasis while promoting immune evasion. To transform this vulnerability into a therapeutic opportunity, we developed an H₂S-responsive dual prodrug system (As-Cu/DSF@TPP⁺) that leverages endogenous H₂S overexpression as a biochemical trigger. This system operates through a cascading mechanism: (1) Tumor-specific H₂S activation reduces nontoxic As⁵⁺ to cytotoxic As³ ⁺, disrupting mitochondrial copper homeostasis and initiating cuproptosis via lipoylated protein aggregation; (2) Released Cu²⁺ reacts with H₂S to generate photothermally active copper sulfide, enabling localized hyperthermia therapy; (3) Disulfiram-derived CuET establishes a self-amplifying loop, simultaneously depleting H₂S through CBS enzyme inhibition and amplifying copper accumulation. The coordinated action achieves dual therapeutic breakthroughs: cascading cuproptosis through mitochondrial copper overload and Fe-S cluster destabilization, coupled with immunogenic cell death-driven TME remodeling that enhances dendritic cell maturation and cytotoxic T-cell infiltration. By integrating H₂S scavenging, cuproptosis induction, and photothermal-immunotherapy, this strategy establishes a \"gas signaling molecule-programmed nanotherapy\" paradigm. It not only overcomes CRC-specific resistance mechanisms but also provides a universal framework for targeting H₂S-high malignancies, demonstrating how endogenous tumor defense systems can be repurposed into precision therapeutic weapons.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102853"},"PeriodicalIF":13.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation-responsive monocyte-biomimetic nanobubbles realizing microvascular recanalization and xenon neuroprotection in ischemic stroke 炎症反应性单核细胞仿生纳米泡实现缺血性脑卒中微血管再通和氙神经保护

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-07-12 DOI: 10.1016/j.nantod.2025.102851

Moran Wang , Wenjun Zhao , Qiang Zhang , Mei Li , Xiang Sun , Kailin Wang , Bin Huang , Mingfei Pan , Juan Jin , Ning Gu

{"title":"Inflammation-responsive monocyte-biomimetic nanobubbles realizing microvascular recanalization and xenon neuroprotection in ischemic stroke","authors":"Moran Wang , Wenjun Zhao , Qiang Zhang , Mei Li , Xiang Sun , Kailin Wang , Bin Huang , Mingfei Pan , Juan Jin , Ning Gu","doi":"10.1016/j.nantod.2025.102851","DOIUrl":"10.1016/j.nantod.2025.102851","url":null,"abstract":"<div><div>Ischemic stroke (IS) is an acute and severed disease with vascular inflammation prior to thrombus events. Considering the current treatment strategies focus on the thrombus-target effect, reaching the early intervention and extending therapeutic time windows remains a key challenge. Herein, inspired by the monocyte infiltration mechanism to the early stroke lesion, nanobubbles encapsulating xenon with monocyte membrane shell (Xe-MNBs) are designed for emergency theranostics of IS. Xe-MNBs quickly target to the inflammatory damaged vessels and competitively inhibit the inflammatory progression via abundant membrane cytokine receptors. Afterwards, Xe-MNBs serve as a platform to recanalize microvasculature and locally deliver neuroprotective Xe in the stroke lesion, synergistically extending the “door-to-needle” streamline. In photothrombotic ischemic stroke mice, the aggregation of Xe-MNBs in stroke brains reaches approximately 8.2 times higher than normal brains within 0.5 h of stroke induction. <em>In vivo</em> results confirmed that blood flow perfusion, neuroprotection and inflammation inhibition can significantly improve the neurological recovery of stroke mice, also investigated by gene transcriptome analysis. This work provides a novel monocyte-biomimetic nanosystem for inflammation-responsive drug delivery and gives a proof of concept for priority management of IS with Xe-MNBs.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102851"},"PeriodicalIF":13.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing hydrogen spillover: Biomimetic dual-site platinum-gold catalyst mimicking NAD+ -reducing hydrogenase 利用氢溢出：模拟NAD+还原氢化酶的仿生双位点铂金催化剂

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-07-11 DOI: 10.1016/j.nantod.2025.102852

Panpan Zhao , Rui Li , Jianguo Zhao , Yuehan Zhang , Zhixuan Yu , He Zhang , Shaojun Dong

{"title":"Harnessing hydrogen spillover: Biomimetic dual-site platinum-gold catalyst mimicking NAD+ -reducing hydrogenase","authors":"Panpan Zhao , Rui Li , Jianguo Zhao , Yuehan Zhang , Zhixuan Yu , He Zhang , Shaojun Dong","doi":"10.1016/j.nantod.2025.102852","DOIUrl":"10.1016/j.nantod.2025.102852","url":null,"abstract":"<div><div>The hydrogen spillover phenomenon in heterogeneous catalysis shares similarities with the proton-coupled electron transfer (PCET) mechanism observed in natural enzymes. Drawing inspiration from these mechanisms, biomimetic dual-site platinum-gold (PtAu) catalyst was theoretical designed as a model to mimic the function of soluble NAD<sup>+</sup>-reducing hydrogenases (SH). This model catalyst facilitates efficient hydrogen oxidation and NAD<sup>+</sup> reduction, offering potential applications in both bioelectrocatalysis and biosynthetic systems. In the design, Pt and Au simulated the NiFe and FMN active sites of SH, respectively, with hydrogen spillover serving as an alternative to the PCET mechanism. Experimental results and theoretical calculations revealed the individual contribution and synergistic interactions between Pt and Au, where Pt sites dissociated H<sub>2</sub> to produce active hydrogen which spontaneously spilled to neighboring Au sites for adsorbed NAD<sup>+</sup> hydrogenation. In biocatalysis, PtAu catalyst exhibited superior NAD<sup>+</sup> conversion efficiency and selectivity toward 1,4-NADH compared to previously reported Pt-based catalysts. In electrocatalysis, a H<sub>2</sub>/O<sub>2</sub> enzymatic biofuel cell was constructed, achieving a maximum power output exceeding 2.0 mW cm<sup>−2</sup> while maintaining excellent operational stability. This mechanism-inspired strategy provided valuable insights into the understanding and design of catalysts, thereby offering greater potential for applications in replacing natural enzymatic catalysis.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102852"},"PeriodicalIF":13.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycyrrhetinic acid-albumin nanoparticles with bimodal pharmacological activities for time-dependent restoration of acute liver injury 具有双峰药理活性的甘草次酸-白蛋白纳米颗粒对急性肝损伤时间依赖性恢复的作用

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-07-09 DOI: 10.1016/j.nantod.2025.102849

Baoyuan Zhang , Yixin Sun , Shengbo Yuan , Shufang Zheng , Yongke Zhang , Zuo Zhang , Dongyu Zhang , Jiayu Guo , Xianbao Shi , Jin Sun , Zhonggui He , Bingjun Sun

{"title":"Glycyrrhetinic acid-albumin nanoparticles with bimodal pharmacological activities for time-dependent restoration of acute liver injury","authors":"Baoyuan Zhang , Yixin Sun , Shengbo Yuan , Shufang Zheng , Yongke Zhang , Zuo Zhang , Dongyu Zhang , Jiayu Guo , Xianbao Shi , Jin Sun , Zhonggui He , Bingjun Sun","doi":"10.1016/j.nantod.2025.102849","DOIUrl":"10.1016/j.nantod.2025.102849","url":null,"abstract":"<div><div>Acute liver injury (ALI) represents a critical initiating event for deterioration into severe hepatitis or fatal acute liver failure. Glycyrrhizin acid has shown clinical effectiveness in managing liver injury and hepatitis, but it requires metabolic conversion to glycyrrhetinic acid (GA) to be effective. However, the application of GA is impeded by poor solubility and rapid clearance. Given the ultra-high albumin affinity of GA, three GA-human serum albumin nanoparticles (GA@HSA NPs) with optimized mass ratios (1:0.5, 1:1, and 1:2) were reported. Molecular dynamics simulations revealed that GA predominantly occupied structural domain IIA within Sudlow site I of HSA. Upon administration, the hepatic retention of GA@HSA NPs was significantly increased, especially for 1:2 GA@HSA NPs. Notably, GA@HSA NPs exhibited bimodal pharmacological activities, including time-dependent prophylactic and therapeutic effects on ALI, which were achieved by decreasing intracellular nitric oxide (NO), reactive oxygen species (ROS), and restoring pro-inflammatory macrophages to normal macrophages. In preventive mode, 1:2 GA@HSA NPs even restored liver function indicators involved in ALI to normal levels while ensuring safety, displaying potent therapeutic benefits. These findings established a paradigm for liver targeting therapy, offering mechanistic insights and translational potential for ALI management.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102849"},"PeriodicalIF":13.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-SV2C single domain nanobodies for molecular imaging in androgen receptor positive prostate cancer 抗sv2c单域纳米体在雄激素受体阳性前列腺癌中的分子成像研究

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-07-09 DOI: 10.1016/j.nantod.2025.102846

Ziye Liu , Jiahao Zhou , Jiangyan Liu , Chengmu Zhao , Zhencun Cui , Qinqin Wang , Wantong Ma , Xinyao Ma , Futian Tang , Xin Wang , Yumin Li , Dejuan Zhi , Dongsheng Wang

{"title":"Anti-SV2C single domain nanobodies for molecular imaging in androgen receptor positive prostate cancer","authors":"Ziye Liu , Jiahao Zhou , Jiangyan Liu , Chengmu Zhao , Zhencun Cui , Qinqin Wang , Wantong Ma , Xinyao Ma , Futian Tang , Xin Wang , Yumin Li , Dejuan Zhi , Dongsheng Wang","doi":"10.1016/j.nantod.2025.102846","DOIUrl":"10.1016/j.nantod.2025.102846","url":null,"abstract":"<div><div>Prostate cancer (PCa) is one of the most prevalent malignant tumors in men worldwide. Because of its highly heterogeneous, the accurate diagnosis of PCa is critical to the selection of appropriate treatment strategy. In present work, high affinity nanobody 1-H9, a variable domain of heavy-chain antibody (VHH) against SV2C was developed by phage display library screening. Showing by 1-H9, SV2C was selectively expressed in androgen receptor (AR) positive prostate tumor cell LNCaP, but not AR negative tumor cell PC3. In LNCaP cells, SV2C and AR were first observed to co-localize on the mitochondrial membrane. Subsequent pull-down assays confirmed that AR, when used as bait, directly interacted with SV2C (the prey), suggesting a physical association between the two proteins. Furthermore, on clinical PCa biopsy specimens, SV2C and AR staining were highly correlated in immunohistochemistry assay. Confirmed in pre-clinical animal models, both fluorescence imaging and <sup>68</sup>Ga PET/CT imaging showed SV2C was significant enriched in LNCaP tumor. Our results suggest that in contrast to SV2A being used for neuronal endocrine PCa diagnosis, SV2C is a novel biomarker for accurate diagnosis of AR positive PCa. The nanobody 1-H9 developed against SV2C-LD4 domain is promising to be used as an effective molecular imaging probe for AR positive PCa.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102846"},"PeriodicalIF":13.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-pumping, pH-responsive Janus fibrous dressing for enhanced immunomodulation and accelerated diabetic wound healing 自泵，ph响应Janus纤维敷料增强免疫调节和加速糖尿病伤口愈合

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-07-04 DOI: 10.1016/j.nantod.2025.102847

Zhou Sha , Jing Li , Yuheng Song , Hongchuang Li , Hongmei Liu , Jiahui Fan , Xueyong Li , Xiang Fei , Meifang Zhu

{"title":"Self-pumping, pH-responsive Janus fibrous dressing for enhanced immunomodulation and accelerated diabetic wound healing","authors":"Zhou Sha , Jing Li , Yuheng Song , Hongchuang Li , Hongmei Liu , Jiahui Fan , Xueyong Li , Xiang Fei , Meifang Zhu","doi":"10.1016/j.nantod.2025.102847","DOIUrl":"10.1016/j.nantod.2025.102847","url":null,"abstract":"<div><div>Diabetic wounds, characterized by excessive exudate accumulation and dysregulated inflammation, pose a global healthcare challenge due to their persistent non-healing nature. Traditional therapies often fail to simultaneously address three critical healing requirements: precise exudate management, coordinated inflammation-immune modulation, and pro-regenerative microenvironment establishment. Here, we present an innovative self-pumping Janus fibrous dressing integrating curcumin-loaded polycaprolactone nanofibers with cotton gauze. Its gradient architecture enables spontaneous exudate drainage and dynamic microenvironment modulation, establishing an optimal milieu for accelerated wound healing. Comprehensive <em>in vitro</em> investigations validate the dressing’s multifunctionality, including sensitive colorimetric pH response, antibacterial properties (>99 % inhibition against <em>S. aureus</em>), and antioxidant capabilities (>90 % DPPH radical scavenging). <em>In vivo</em> studies in a diabetic mice model demonstrate the dressing’s superior wound healing efficacy, with ∼47 % reduction in wound edge maceration, mitigated inflammatory responses, and enhanced angiogenesis compared to commercial cotton dressings. This novel approach provides a promising foundation for the development of advanced wound dressings tailored for the management and healing of chronic wounds.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102847"},"PeriodicalIF":13.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold nanoparticle-loaded multifunctional Ti3C2Tx MXene nanosheets fabricated by in situ reduction to effectively enhance their catalase-like activity for tumor therapy 利用原位还原法制备了负载金纳米粒子的多功能Ti3C2Tx MXene纳米片，有效增强了其过氧化氢酶样活性，用于肿瘤治疗

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-06-28 DOI: 10.1016/j.nantod.2025.102848

Yuhao Guo , Jinyu Wang , Xiaomei Wu , Qianqian Qiao , Tao Liao , Linwei Li , Ziqiang Xu , Di-Wei Zheng , Ying Kuang , Wenqian Yu , Cao Li

{"title":"Gold nanoparticle-loaded multifunctional Ti3C2Tx MXene nanosheets fabricated by in situ reduction to effectively enhance their catalase-like activity for tumor therapy","authors":"Yuhao Guo , Jinyu Wang , Xiaomei Wu , Qianqian Qiao , Tao Liao , Linwei Li , Ziqiang Xu , Di-Wei Zheng , Ying Kuang , Wenqian Yu , Cao Li","doi":"10.1016/j.nantod.2025.102848","DOIUrl":"10.1016/j.nantod.2025.102848","url":null,"abstract":"<div><div>Designing novel, high-performance nanozymes is essential for developing biocatalytic therapeutics, a promising therapeutic approach. In this work, gold nanoparticles (Au NPs)-loaded Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene nanosheets (Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>-Au) are prepared by in situ reduction and then modified with polyethylene glycol (PEG) to obtain a multifunctional anticancer cascade enzyme system, Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>-Au-PEG (TANP). The photothermal properties of Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> in the near-infrared (NIR) region allow for its use in photothermal therapy (PTT). The complexation of Au NPs with Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> significantly enhances the catalase-like (CAT) activity of TANP, while incubating the glucose oxidase (GOx)- and peroxidase (POD)-like properties of TANP. The strong CAT-like property of TANP allows it to decompose the H<sub>2</sub>O<sub>2</sub> overexpressed in cancer cells into O<sub>2</sub>, which alleviates hypoxia. It can also be used for glucose catabolism in cancer cells, <em>i.e.</em>, GOx-like induced starvation therapy. H<sub>2</sub>O<sub>2</sub>, one of the glucose degradation products, can be supplied to TANP to generate O<sub>2</sub> and POD-like induced reactive oxygen species (ROS) generation to kill cancer cells. Density functional theory (DFT) calculations provide possible reasons for the enhanced CAT-like activity of Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>-Au. Photothermal can enhance enzyme activity and can also be combined with biocatalytic therapy to achieve good therapeutic effects.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102848"},"PeriodicalIF":13.2,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative wrinkle fabrication on polymer surfaces: Applications in optics and anti-counterfeiting 聚合物表面的创新皱纹制造：在光学和防伪中的应用

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-06-27 DOI: 10.1016/j.nantod.2025.102843

Dengchong Feng , Xixi Su , Rui Chen , Haoran Chen , Yuzhao Yang , Shaolin Lu , Zhongke Yuan , Xudong Chen

{"title":"Innovative wrinkle fabrication on polymer surfaces: Applications in optics and anti-counterfeiting","authors":"Dengchong Feng , Xixi Su , Rui Chen , Haoran Chen , Yuzhao Yang , Shaolin Lu , Zhongke Yuan , Xudong Chen","doi":"10.1016/j.nantod.2025.102843","DOIUrl":"10.1016/j.nantod.2025.102843","url":null,"abstract":"<div><div>In the realm of advanced materials, wrinkling surface materials stand out for their innovative use of buckling instability to create adjustable micro-nano structures. This technique offers significant advantages over traditional methods, including simplified processes, lower reliance on high-precision equipment, and excellent scalability. In recent years, with a deeper understanding of the mechanisms behind wrinkle formation, the regular and tunable periodic morphology has enabled wrinkling surface materials to shine in the field of optics. Subsequently, the development of wrinkle materials with various responsive properties has opened up new possibilities for cutting-edge applications in anti-counterfeiting and robust smart devices. This review summarizes the principles and methods for generating wrinkles, detailing the mechanisms and main approaches for controlling the surface morphology of wrinkling materials. Finally, we review the applications of wrinkling materials in optics and optical encryption, highlighting their emerging utility and potential in these fields.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102843"},"PeriodicalIF":13.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A dual-cell-targeting epigenetic nano-editor for reshaping the intratumoral T cell niche 用于重塑肿瘤内T细胞生态位的双细胞靶向表观遗传纳米编辑器

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-06-26 DOI: 10.1016/j.nantod.2025.102842

Wenyan She , Pengdi Zhang , Linlin Guo , Yu Zhang , Haoyi Zhu , Yaping Wang , Yichao Zheng , Lin Hou

{"title":"A dual-cell-targeting epigenetic nano-editor for reshaping the intratumoral T cell niche","authors":"Wenyan She , Pengdi Zhang , Linlin Guo , Yu Zhang , Haoyi Zhu , Yaping Wang , Yichao Zheng , Lin Hou","doi":"10.1016/j.nantod.2025.102842","DOIUrl":"10.1016/j.nantod.2025.102842","url":null,"abstract":"<div><div>T cell-based immunotherapies benefit only a minority of patients, primarily due to insufficient CD8<sup>+</sup> T cell quantity and functional exhaustion. However, integrated strategies addressing both challenges remain scarce. Epigenetic dysregulation has recently been recognized as an important factor interfering with T cell responses in the tumor microenvironment. Herein, we develop an epigenetic nano-editor (P@cPG/sg) that simultaneously targets the epigenetic lysine-specific demethylase 1 (LSD1) in both tumor cells and T cells to reprogram the intratumoral T cell niche. The nano-editor consists of two guanidinium-based cationic carriers complexed with LSD1-targeting CRISPR/Cas9 plasmids, and can de-crosslink into tumor cell-targeting nanoparticles (P<sub>M</sub>G/sg) and T cell-targeting nanoparticles (P<sub>T</sub>G/sg). P<sub>M</sub>G/sg downregulates LSD1 in tumor cells, leading to the upregulation of chemokines that promote CD8<sup>+</sup> T cell infiltration. Meanwhile, P<sub>T</sub>G/sg reduces LSD1 in T cells, lowering PD-1 expression, significantly enhancing T cell proliferation and rejuvenating exhausted cytotoxic CD8<sup>+</sup> T cells <em>in situ</em>. Simultaneous LSD1 knockdown establishes a self-reinforcing cascade of anti-tumor immunity, achieving over 75 % tumor growth inhibition in both murine and humanized gastric cancer models. Thus, this nano-editor represents a standalone epigenetic immunotherapy that synchronously enhances intratumoral CD8<sup>+</sup> T cell quantity and effector function, overcoming key limitations of current T cell-based immunotherapies.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102842"},"PeriodicalIF":13.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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