Nano Today最新文献

{"title":"Geometric-aware deep learning enables discovery of bifunctional ligand-based liposomes for tumor targeting therapy","authors":"Jiaxuan Xia ,&nbsp;Zicheng Gan ,&nbsp;Jixian Zhang ,&nbsp;Meichen Dong ,&nbsp;Shengyao Liu ,&nbsp;Bangchun Cui ,&nbsp;Pengcheng Guo ,&nbsp;Zhiqing Pang ,&nbsp;Tun Lu ,&nbsp;Ning Gu ,&nbsp;Defang Ouyang ,&nbsp;Chengtao Li ,&nbsp;Shuangjia Zheng ,&nbsp;Jianxin Wang","doi":"10.1016/j.nantod.2025.102668","DOIUrl":"10.1016/j.nantod.2025.102668","url":null,"abstract":"<div><div>Limited tumor targeting capacity of conventional liposomes compromises their clinical outcomes in tumor therapy. Although ligand-based liposomes show promise for improved tumor targeting efficiency, their transition to clinical use is impeded by the complexity of necessary ligand modifications on liposomal membranes. Certain bifunctional natural products, offering both liposomal membrane-regulating and tumor-targeting ligands properties, have shown tumor targeting potential after prepared into liposomes without the need for ligands synthesis, but their discovery has been hindered by the constraints of conventional screening methods. Here, we propose combining deep learning with wet experimentation for rapid discovery of new bifunctional ligands. Utilizing pre-trained geometric-aware neural networks, we simultaneously modeled predictions for membrane-regulating and glucose transporter 1-ligand functions. The trained models identified nine top candidates from &gt; 300,000 natural products, six of which demonstrated the anticipated dual functionality upon experimental validation. The lead liposome, Ilexgenin A (Ile)-based liposome, demonstrated superior tumor-targeting and anti-tumor effect compared to the existing bifunctional ligand-based liposome. Further analysis elucidated Ile's mechanisms in immunoregulation and chemotherapy sensitization. This approach signifies the potential of deep learning in design of intelligent and targeting drug delivery systems.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102668"},"PeriodicalIF":13.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in generating power coupled with atmospheric water harvesting","authors":"Xionggang Chen ,&nbsp;Chenggong Xu ,&nbsp;Tianqi Wei ,&nbsp;Zhiwei Chen ,&nbsp;Yifan Liu ,&nbsp;JinXia Huang ,&nbsp;Zhiguang Guo","doi":"10.1016/j.nantod.2025.102661","DOIUrl":"10.1016/j.nantod.2025.102661","url":null,"abstract":"<div><div>The global scarcity of freshwater and energy, which is unevenly distributed across time and space, represents a significant challenge to sustainable development. Atmospheric water harvesting, a process that harvests moisture from the atmosphere, holds significant potential for alleviating freshwater shortages, while the energy generated during this process may also contribute to mitigating energy crises. The integration of energy harvesting and conversion with atmospheric water harvesting has increasingly attracted the attention of researchers. This review explores the potential for electricity generation through fog and absorption-based atmospheric water harvesting, while categorizing and summarizing the latest advancements in power generation technologies and mechanisms. Furthermore, it discusses the progress in research on the simultaneous harvesting of atmospheric water and electricity generation in detail. Finally, the challenges and opportunities in developing systems of atmospheric water harvesting and electricity conversion are presented. Strategies, such as the development of multifunctional integrated systems, are proposed to enhance the efficiency of simultaneous atmospheric water harvesting and electricity generation and to promote their practical applications.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102661"},"PeriodicalIF":13.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Converting the redox inactive P-block metal aluminum into active Fenton-like atomically dispersed catalysts to customize singlet oxygen generation","authors":"Mingyang Song ,&nbsp;Peng Zhang ,&nbsp;Fagen Zhang,&nbsp;Chen Zhou,&nbsp;Dandan Deng,&nbsp;Tong Li,&nbsp;Yaowen Gao,&nbsp;Chun Hu","doi":"10.1016/j.nantod.2025.102663","DOIUrl":"10.1016/j.nantod.2025.102663","url":null,"abstract":"<div><div>Transition-metal-based single-atom catalysts (TM-SACs) are popular for peroxymonosulfate (PMS) conversion into singlet oxygen (¹O₂) in Fenton-like chemistry, however, p-block atomically dispersed metal catalysts have been rarely explored due to the delocalized s/p bands of p-block metals. Herein, guided by theoretical simulations, we have successfully converted a redox inactive p-block metal aluminum (Al) into an active Fenton-like atomically dispersed Al−N₃ catalyst (Al-NC-3) to customize ¹O₂ generation via PMS oxidation. The Al-NC-3 catalyst exhibits fantastic Fenton-like performance and robust stability for bisphenol A (BPA) degradation with a specific activity of 3.03 × 10⁻³ L min⁻¹ m⁻², which is 8.3-fold higher than that of Al−N₄-featured Al-NC-4 counterpart and even comparable to most TM-SACs. The unsaturated Al−N₃ species function as Lewis acid sites enabling directional electron extraction from PMS to initiate PMS oxidation for the exclusive production of ¹O₂. Theoretical calculations reveal that structural alteration from Al−N₄ to Al−N₃ shifts the p-band center of Al closer to the Fermi energy, which enhances the interaction between PMS and Al−N₃ sites and facilitates greater electron transfer from PMS to the Al<img>N₃ moiety, accounting for superior specific activity of Al-NC-3 to Al-NC-4. This work offers useful guidance to design novel Fenton-like SACs for oriented ¹O₂ generation towards environmental applications.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102663"},"PeriodicalIF":13.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphatidylserine decorated inhalable immunostimulants to eradicate pulmonary metastasis through alveolar macrophage polarization and phagocytosis restoration in situ","authors":"Xiayun Chen ,&nbsp;Qianqian Liu ,&nbsp;Baixue Yu ,&nbsp;Yi Cen ,&nbsp;Yibin Liu ,&nbsp;Youzhi Tang ,&nbsp;Ning Guo ,&nbsp;Tao Wang ,&nbsp;Shiying Li","doi":"10.1016/j.nantod.2025.102667","DOIUrl":"10.1016/j.nantod.2025.102667","url":null,"abstract":"<div><div>Pulmonary metastasis is frequently observed across various malignant tumors, contributing to a considerable mortality and featuring with a low immune response rate. In this work, a pathological analysis of the pulmonary metastasis indicates that alveolar macrophages (AMs) are prone to be polarized into immunosuppressive M2 phenotype, and the drug screening confirms that TLR7/8 agonists (R848) and SHP2 inhibitor (SHP099) would polarize AMs into immune-promoting M1 phenotype and restore their phagocytic elimination behavior. Based on these discovery, Inhalable and Alveolar Macrophage targeted IMmunostimulants (designated as I-AM-IMs) are fabricated by using phosphatidylserine decorated liposomes to co-deliver R848 and SHP099. Nebulization inhalation of I-AM-IMs enables the passive and active targeted drug delivery for AMs resided in lower respiratory tract, promoting AMs polarization and phagocytosis restoration <em>in situ</em>. Meanwhile, phenotype reprogramming of AMs could direct the phagocytic elimination of pulmonary metastatic tumor cells, trigger the release of cytotoxic cytokines and activate CD8 T cell specific anti-tumor immunity. <em>In vitro</em> and <em>in vivo</em> studies demonstrate the superior immunotherapeutic effects of I-AM-IMs to eradicate pulmonary metastasis, which might provide a versatile and effective strategy for localized pulmonary metastasis immunotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102667"},"PeriodicalIF":13.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Codelivery of fibronectin and rapamycin via bioactive phosphorus dendrimers to ameliorate Alzheimer’s disease through macrophage autophagy, oxidative stress alleviation and polarization modulation","authors":"Mengsi Zhan ,&nbsp;Waicong Dai ,&nbsp;Huxiao Sun ,&nbsp;Yue Gao ,&nbsp;Yu Zou ,&nbsp;Regis Laurent ,&nbsp;Xiyang Sun ,&nbsp;Serge Mignani ,&nbsp;Jean-Pierre Majoral ,&nbsp;Mingwu Shen ,&nbsp;Xiangyang Shi","doi":"10.1016/j.nantod.2025.102664","DOIUrl":"10.1016/j.nantod.2025.102664","url":null,"abstract":"<div><div>The primary pathogenic mechanisms underlying neurodegenerative diseases such as Alzheimer’s disease (AD) involve neuroinflammation, oxidative stress and abnormal protein aggregation, while the main challenges facing effective treatment are limited drug targeting capabilities and the blood-brain barrier (BBB) that impedes drug delivery to damaged brain regions. To address these challenges, a nanosystem based on complexes of bioactive <em>per se</em> phosphorus dendrimers (AK-76) with hydroxyl surface groups and protein fibronectin (FN) with both targeting and therapeutic functions that were physically loaded with rapamycin was developed. The resulting R@A/F (R for rapamycin, A for dendrimer, and F for FN) nanocomplexes (NCs) with a size of 187.3 nm demonstrate good stability, cytocompatibility and targeting performance. We show that the R@A/F NCs can cooperatively modulate microglia by lowering reactive oxygen species level, restoring mitochondrial membrane potential, enhancing autophagy, promoting microglia M2 polarization, and suppressing inflammatory cytokine secretion <em>in vitro</em>. With the assistance of dendrimer terminal hydroxyl groups, the R@A/F NCs can cross the BBB and improve cognitive and memory impairments in an AD mouse model by reducing brain inflammation, stimulating autophagy and facilitating Aβ protein degradation. Our study offers a versatile and highly adaptable nanoplatform for advancing the combined treatment of neuroinflammatory diseases, thus representing a significant step forward in addressing the challenges of AD therapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102664"},"PeriodicalIF":13.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical programming for micro- and nanoarchitectonics of 3D/4D-printed thermoelectric materials","authors":"Keval K. Sonigara ,&nbsp;Martin Pumera","doi":"10.1016/j.nantod.2025.102658","DOIUrl":"10.1016/j.nantod.2025.102658","url":null,"abstract":"<div><div>Thermoelectric (TE) materials are important for TE devices that enable waste heat/cold harvesting, energy storage, and thermal sensing applications. Although significant development has been made in TE materials discovery, fabrication methods and designs for TE devices and modules remain a challenge. Recently, three-dimensional (3D) and four-dimensional (4D) printing of TE materials have become essential tools for creating efficient module designs with micro- to nano-scale structures while also minimizing waste generation. However, to achieve the desired print properties and TE material architecture from nano–micro to macro, chemical programming is necessary during feed/ink formulation for the printing procedure. In this review, we focused on TE materials and device fabrication progress in view of chemical programming for 3D/4D-printed TE materials. A brief introduction is provided of TE effects, TE materials, chemical programming approaches, and 3D/4D printing methods. We considered various classes of inorganic, carbon, and polymer-based TE materials to unveil the chemical programming approaches developed to print them. It was found that a significant gap exists in the transition from 3D to 4D printing of TE materials, which could be game-changing for smart applications of TE devices. Recent attempts of 4D printing suggest that chemically programmed smart material integration in TE devices could lead to success for finite applicable TE platforms. Finally, future perspectives and challenges are explored to identify limitations and possible ways forward. Overall, this review provides fresh insights on chemical programming approaches to implement 3D/4D printing of TE materials.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102658"},"PeriodicalIF":13.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combinatorial screening of nanomedicines in patient-derived cancer organoids facilitates efficient cancer therapy","authors":"Jie Liang ,&nbsp;Dong-Kun Zhao ,&nbsp;Hao-Ming Yin ,&nbsp;Tai-Yu Tian ,&nbsp;Jian-Kang Kang ,&nbsp;Song Shen ,&nbsp;Jun Wang","doi":"10.1016/j.nantod.2025.102665","DOIUrl":"10.1016/j.nantod.2025.102665","url":null,"abstract":"<div><div>Patient-derived tumor organoids (Pat.-ORG) have emerged as invaluable tools for identifying synergistic drug combinations, including the precise types and proportions of combined drugs, to guide efficacious therapy. However, the variability in pharmacokinetic profiles among different medications can significantly impact the tumor accumulation of the <em>in vitro</em> screened drug regimens, potentially compromising their ultimate <em>in vivo</em> therapeutic efficacy. Given the remarkable capacity of nanocarriers to deliver multiple drugs with diverse physicochemical properties and to harmonize their <em>in vivo</em> metabolic characteristics, we propose leveraging Pat.-ORG-based drug combination screening using nanomedicine to bridge the gap between <em>in vitro</em> and <em>in vivo</em> outcomes that traditional drug screening methods often encounter. In this study, 15 exquisitely engineered nanomedicines were combined at five distinct drug ratios, yielding 525 unique nanomedicine combinations that were rigorously screened using colorectal cancer organoids to identify those exhibiting remarkable synergistic effects. <em>In vivo</em> experiments validated that the selected nanomedicine combinations demonstrated superior antitumor efficacy compared to their free-drug counterparts. Our research underscores the immense potential of integrating organoid modeling with nanomedicine technology to optimize combination treatment screening and advance the development of effective cancer therapies.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102665"},"PeriodicalIF":13.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine-learning assisted novel insulation layer stripping technology for upgrading the transparent EMI shielding materials","authors":"Yilin Hao ,&nbsp;Chuyang Liu ,&nbsp;Rapkatjan Keram ,&nbsp;Huaxin Song ,&nbsp;Yujing Zhang ,&nbsp;Guangbin Ji","doi":"10.1016/j.nantod.2025.102660","DOIUrl":"10.1016/j.nantod.2025.102660","url":null,"abstract":"<div><div>Silver nanowires (AgNW) hold immense potential to be promoted as competitive transparent electromagnetic interference (EMI) shielding materials. To remove the insulating polyvinyl pyrrolidone (PVP) layer on the surface of AgNW, a machine learning prediction framework (MLPF) is proposed to offer guidance for a novel approach to remove insulating layers of AgNW in the films state. The trained machine learning model achieves an R² value of 0.82 on the test set, demonstrating exceptional generalization capabilities. Through experimental validation, the machine-learning assisted stripping process significantly improves the SE values of AgNW film from 20.81 dB to 28.66 dB, representing a percentage improvement of 37.72 % and maintaining high light transmittance of 82 % at 550 nm. Designed framework not only provides a brand new strategy to remove the PVP effectively, but also expands the application of machine learning in the realm of upgrading transparent EMI shielding materials for the first time.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102660"},"PeriodicalIF":13.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the exsolution mechanisms and investigation of the catalytic processes of Sr2FeMo0.65Ni0.35O6-δ using in situ transmission electron microscopy","authors":"Pritam K. Chakraborty ,&nbsp;Stephanie E. Wolf ,&nbsp;Govind Ummethala ,&nbsp;Ansgar Meise ,&nbsp;Tobias Mehlkoph ,&nbsp;Junbeom Park ,&nbsp;Marc Heggen ,&nbsp;Amir H. Tavabi ,&nbsp;Vaibhav Vibhu ,&nbsp;André Karl ,&nbsp;Eva Jodat ,&nbsp;L.G.J. (Bert) de Haart ,&nbsp;Rafal E. Dunin-Borowski ,&nbsp;Shibabrata Basak ,&nbsp;Rüdiger-A. Eichel","doi":"10.1016/j.nantod.2025.102649","DOIUrl":"10.1016/j.nantod.2025.102649","url":null,"abstract":"<div><div>Solid oxide cells (SOCs) are likely to play crucial role in the green energy transition, but their widespread adoption is hindered by degradation issues, particularly catalyst agglomeration. Nanoparticle exsolution in double-perovskite materials offers a promising solution by creating electrode materials with stable metallic nanocatalysts strongly bonded to the parent oxide, mitigating high-temperature agglomeration issues. Thus, understanding the dynamic evolution of microstructure and catalytic behavior in such materials is vital for developing high-performing SOC catalysts. This study utilized a multimodal approach to investigate the dynamics of exsolution in Sr₂FeMo_0.65Ni_0.35O_6-δ (SFM-Ni) and its effect on cell performance. <em>In situ</em> environmental transmission electron microscopy (ETEM), <em>in situ</em> transmission electron microscopy (TEM) coupled with mass spectrometry visualized the formation and the stability of exsolved particles especially at the concave faces of the parent material during chemical conversion of CO from CO₂. Simultaneously, macro-scale cell experiments coupled with electrochemical impedance spectroscopy, and focused ion beam-scanning electron microscopy (FIB-SEM) tomography, apart from verifying the nanoscale observations, provided crucial insights into the correlation between the exsolution process observed at the micro-scale and the overall cell performance. These findings offers valuable insights into the design and optimization of improved electrode materials for SOCs. Understanding the dynamic behavior of exsolved catalysts would help in enhancing the electrochemical performance at both the nano and macro levels, ultimately advancing the field of sustainable energy technologies.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102649"},"PeriodicalIF":13.2,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143351159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verteporfin-integrated conductive zwitterionic hydrogels for scarless wound management","authors":"Xinyue Cao ,&nbsp;Minhui Lu ,&nbsp;Jinglin Wang ,&nbsp;Yu Wang ,&nbsp;Yuanjin Zhao","doi":"10.1016/j.nantod.2025.102659","DOIUrl":"10.1016/j.nantod.2025.102659","url":null,"abstract":"<div><div>Hydrogels have outstanding values in wound management. Endeavors in this area have been concentrated on the improvement of the inherent functions of hydrogels and the cooperation with effective bioactives, achieving scarless wound therapy. Herein, we develop a novel verteporfin (VP)-integrated conductive zwitterionic [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) (SBMA) hydrogels for promoting wound healing process and prevention scar formation. The hydrogels with VP’s encapsulation are formed through PEDOT:PSS-promoted spontaneous polymerization of SBMA. The obtained dual-conductive hydrogels possess high resilience, desired adhesion, and inherent antibacterial property, making them extremely suitable for treating skin defects through close contact with wound area, infection reduction and lesions’ electrical field enhancement. Additionally, the loaded VP can be constantly released to wound sites and exhibits anti-scarring effect by inhibiting the Yes-Associated Protein activation and collagen deposition. Based on these advantages, our hydrogel patch has been proven to achieve satisfying therapeutic effects for <em>in vivo</em> scarless wound management. Thus, we believe that the proposed VP-integrated conductive SBMA hydrogels are valuable as multifunctional dressings for wound and scar management.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102659"},"PeriodicalIF":13.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143306452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}