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Intranasal hybrid vesicles delivering personalized in situ nano-vaccines induce glioblastoma remodeling to sensitize immunotherapy 鼻内杂交囊泡提供个性化的原位纳米疫苗诱导胶质母细胞瘤重塑以增强免疫治疗的敏感性
IF 13.2 1区 材料科学
Nano Today Pub Date : 2025-06-20 DOI: 10.1016/j.nantod.2025.102840
Xue Wang , Hanwen Zhang , Mingzhi Han , Fucai Chen , Yingjie Zhang , Kuanhan Feng , Jinghuang Wang , Yali Shi , Peng Cao , Liuqing Di , Ruoning Wang
{"title":"Intranasal hybrid vesicles delivering personalized in situ nano-vaccines induce glioblastoma remodeling to sensitize immunotherapy","authors":"Xue Wang ,&nbsp;Hanwen Zhang ,&nbsp;Mingzhi Han ,&nbsp;Fucai Chen ,&nbsp;Yingjie Zhang ,&nbsp;Kuanhan Feng ,&nbsp;Jinghuang Wang ,&nbsp;Yali Shi ,&nbsp;Peng Cao ,&nbsp;Liuqing Di ,&nbsp;Ruoning Wang","doi":"10.1016/j.nantod.2025.102840","DOIUrl":"10.1016/j.nantod.2025.102840","url":null,"abstract":"<div><div>Personalized in situ tumor vaccine (PISTV), an attractive type of cancer immunotherapy, promotes a potent T cell anti-cancer immune response in multiple malignancies. Nevertheless, the limited cancer elimination efficacy of PISTV was exhibited in glioblastoma (GBM). Herein, an intranasal hybrid vesicle is designed based on ginseng-derived nanoparticles (GDNPs) fusing with liposomes, encapsulating shikosin (SKN), muscone, and MAN-CpG ODN (mCpG) to enable personalized in situ tumor vaccination for amplifying anti-GBM immune response. Following intranasal administration, the hybrid vesicles penetrated the nasal mucosal barrier and circumvented the blood-brain-barrier via the olfactory bulbar pathway. Subsequently, these nano-vaccines reached the tumor site, attributed to ginsenoside Rg3 in GDNPs. SKN-mediated whole tumor cell lysis served as a tumor-antigen pool to combine with immune adjuvant mCpG, resulting in the personalized in situ tumor vaccination, then recruiting dendritic cells (DCs) and promoting DCs maturation. Afterwards, DCs antigen presentation was enhanced to mobilize T cells, differentiating into cytotoxic T lymphocytes, thus inducing adaptive anti-tumor immunity. Furthermore, the GDNPs-mediated tumor-associated macrophages repolarization combines with SKN-blocked glycolytic pathway to reverse the immunosuppressive TME from “cold” into “hot”, thereby inducing innate immunity. We developed a nanoplatform that can deliver immunogenic cell death activators and Toll-like receptor agonists to antigen-capturing cells, synchronously conveying glycolysis inhibitors and TAM repolarization inducers to TME. This work demonstrated its robust capacity to activate innate and adaptive immune responses in distal metastasis, rechallenge, and humanized patient-derived xenograft tumor-bearing mice, providing a promising pathway for immunotherapeutic sensitization of GBM.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102840"},"PeriodicalIF":13.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging piezocatalysts: Metal–organic frameworks and their derivatives 新兴的压电催化剂:金属有机框架及其衍生物
IF 13.2 1区 材料科学
Nano Today Pub Date : 2025-06-20 DOI: 10.1016/j.nantod.2025.102841
Xin Du , Yang Fu , Hamid Arandiyan , Peng Li , Hua Fan , Lingfeng Zhu , Hui Li , Lei Zhang , Tianyi Ma
{"title":"Emerging piezocatalysts: Metal–organic frameworks and their derivatives","authors":"Xin Du ,&nbsp;Yang Fu ,&nbsp;Hamid Arandiyan ,&nbsp;Peng Li ,&nbsp;Hua Fan ,&nbsp;Lingfeng Zhu ,&nbsp;Hui Li ,&nbsp;Lei Zhang ,&nbsp;Tianyi Ma","doi":"10.1016/j.nantod.2025.102841","DOIUrl":"10.1016/j.nantod.2025.102841","url":null,"abstract":"<div><div>Piezoelectric materials, capable of harvesting and transforming mechanical energy into chemical energy, have recently emerged as promising catalysts in environmental wastewater remediation and clean energy production. While this approach holds potential to supplant other advanced techniques, enhancing the inherent piezoelectric properties of conventional inorganic materials remains challenging. This is primarily due to their structural inflexibility and limited surface area, restricting their catalytic efficiency. In comparison with conventional piezocatalysts, metal–organic frameworks (MOFs) offer distinct advantages in terms of crystalline structure, piezoelectric responses, porosity, and surface area. Notably, their tunable structures might improve their thermal and chemical stability at specific condition, achieved through the precise and rational design of their reticular framework based on specific application requirements. This capability enables MOFs to enhance piezocatalytic performance. Over the past few years, significant strides have been made in developing MOF-based materials for piezocatalysis, yet there remains a notable absence of comprehensive review articles on this key topic. Herein this paper aims to fill that gap by presenting benefits and uses of MOFs in piezocatalysis. Commencing with the merits of MOFs, we explore five essential advantages. We also highlight the current utilisation of MOFs in reported piezocatalytic domains. Finally, we will address the future possibilities and opportunities for optimised structure, clarified mechanisms, improved efficiency, and considerations regarding material costs. This timely review aims to insights into the advancement of highly efficient MOF piezocatalysts, fostering potential applications not limited to hydrogen (H<sub>2</sub>) generation and pollutant removal.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102841"},"PeriodicalIF":13.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A DNA-MOF hybrid nanosystem for prediction of photodynamic therapy efficacy via amplified imaging of apoptotic mRNA DNA-MOF杂交纳米系统通过凋亡mRNA的放大成像预测光动力治疗效果
IF 13.2 1区 材料科学
Nano Today Pub Date : 2025-06-17 DOI: 10.1016/j.nantod.2025.102837
Chaowang Li, Deyu Yi, Mengyuan Li, Zhengping Li
{"title":"A DNA-MOF hybrid nanosystem for prediction of photodynamic therapy efficacy via amplified imaging of apoptotic mRNA","authors":"Chaowang Li,&nbsp;Deyu Yi,&nbsp;Mengyuan Li,&nbsp;Zhengping Li","doi":"10.1016/j.nantod.2025.102837","DOIUrl":"10.1016/j.nantod.2025.102837","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) is a promising anticancer treatment modality, however, early evaluation of its therapeutic efficacy remains challenging. Herein, we present a phototheranostic platform that enables in situ monitoring and prediction of PDT efficacy through real-time, amplified imaging of apoptotic mRNA biomarkers. This DNA-MOF nanosystem (denoted as PCN@HCR) integrates of porphyrinic MOFs with DNA-based hybridization chain reaction (HCR) probes, facilitating both efficient PDT and sensitive mRNA detection. In vitro studies showed that PCN@HCR induces irradiation dose-dependent cell apoptosis and specifically detects <em>Bax</em> mRNA through HCR-based signal amplification, revealing a positive correlation between <em>Bax</em> mRNA levels and cell apoptosis. In vivo studies validated that tumor growth was effectively inhibited by PCN@HCR upon lase irradiation, while fluorescent signals of intratumoral <em>Bax</em> mRNA correlated with reduced tumor volumes, confirming the role of <em>Bax</em> mRNA as an potential biomarker for PDT response. This phototheranostic platform offers a promising approach for precise and personalized cancer therapies by providing real-time insights into treatment responses.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102837"},"PeriodicalIF":13.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering dual-gas releasing nanoplatform for enhancing endogenous Ca2+-mediated ion interference therapy 工程双气体释放纳米平台增强内源性Ca2+介导的离子干扰治疗
IF 13.2 1区 材料科学
Nano Today Pub Date : 2025-06-16 DOI: 10.1016/j.nantod.2025.102839
Bing Ren , Yi Wang , Haiyue Wang , Qi Tang , Shiping Yang , Jin-Gang Liu , Huijing Xiang
{"title":"Engineering dual-gas releasing nanoplatform for enhancing endogenous Ca2+-mediated ion interference therapy","authors":"Bing Ren ,&nbsp;Yi Wang ,&nbsp;Haiyue Wang ,&nbsp;Qi Tang ,&nbsp;Shiping Yang ,&nbsp;Jin-Gang Liu ,&nbsp;Huijing Xiang","doi":"10.1016/j.nantod.2025.102839","DOIUrl":"10.1016/j.nantod.2025.102839","url":null,"abstract":"<div><div>Calcium (Ca<sup>2+</sup>) overload-based ion interference therapy (IIT) is emerging as a promising treatment against malignancies, but it is challenged by the intrinsic ionic homeostasis of cancer cells. Herein, a dual-gas nanoplatform, CMS@PDA@RuNO@MnCO (abbreviated as CPNC NPs), is engineered to achieve endogenous multichannel Ca<sup>2+</sup>-overload-mediated IIT to prevent tumor metastasis. Treatment of CPNC NPs with near-infrared (NIR) laser irradiation allows for controlled release of NO and CO. The released NO triggers the opening of the ryanodine receptor channel and the leakage of Ca<sup>2+</sup> leakage from the endoplasmic reticulum. Meanwhile, the released CO induces oxidative stress to activate the transient receptor potential ankyrin subtype 1 channel, facilitating Ca<sup>2+</sup> influx. This dual-action strategy overloads cancer cells with Ca<sup>2+</sup>, leading to mitochondrial damage, adenosine triphosphate depletion, and tumor apoptosis, effectively inhibiting lung metastasis. In vivo assessments exhibited excellent anti-tumor and anti-metastatic potency of CPNC NPs in suppressing tumor proliferation and metastasis under NIR laser exposure. RNA profiling analysis indicated that CPNC NPs treatment and NIR laser exposure markedly regulate Ca<sup>2+</sup>-overload pathways and inhibit metastasis-related gene expression. This study pioneers the use of a dual-gas nanoplatform to disrupt endogenous Ca<sup>2+</sup> homeostasis, providing a promising therapeutic strategy for cancer treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102839"},"PeriodicalIF":13.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wireless chargeable gold Yarnball-mediated mitochondrial depolarization for dendritic cell detainment in programmed brain tumor immunotherapy 在程序性脑肿瘤免疫治疗中,无线充电金yarball介导的线粒体去极化用于树突状细胞滞留
IF 13.2 1区 材料科学
Nano Today Pub Date : 2025-06-16 DOI: 10.1016/j.nantod.2025.102838
Thrinayan Moorthy , Chia-Ko Chen , Zhuo-Hao Liu , Bhanu Nirosha Yalamandala , Thi My Hue Huynh , Hoi Man Iao , Wan-Chi Pan , Hui-Wen Lien , Alan Yueh-Luen Lee , Wen-Hsuan Chiang , Ssu-Ju Li , You-Yin Chen , Shang-Hsiu Hu
{"title":"Wireless chargeable gold Yarnball-mediated mitochondrial depolarization for dendritic cell detainment in programmed brain tumor immunotherapy","authors":"Thrinayan Moorthy ,&nbsp;Chia-Ko Chen ,&nbsp;Zhuo-Hao Liu ,&nbsp;Bhanu Nirosha Yalamandala ,&nbsp;Thi My Hue Huynh ,&nbsp;Hoi Man Iao ,&nbsp;Wan-Chi Pan ,&nbsp;Hui-Wen Lien ,&nbsp;Alan Yueh-Luen Lee ,&nbsp;Wen-Hsuan Chiang ,&nbsp;Ssu-Ju Li ,&nbsp;You-Yin Chen ,&nbsp;Shang-Hsiu Hu","doi":"10.1016/j.nantod.2025.102838","DOIUrl":"10.1016/j.nantod.2025.102838","url":null,"abstract":"<div><div>Activation of the innate immune cascade offers a potential strategy to inhibit glioblastoma (GBM) proliferation. However, immune privilege along with blood-brain barrier (BBB) and low immunogenicity of GBM often limits lymphocyte infiltration. In this study, a wireless charging mitochondria-targeted nanoantenna (WINA) served as a membrane-disrupting and mitochondria-depolarizing agent was developed for interning dendritic cells and a programmed immunotherapy. By convection-enhanced delivery, membrane-disrupting cationic triphenylphosphine (TPP)-conjugated polyglutathione (pGSH) on WINA improves tumor penetration to deep area and targets mitochondria. Under high-frequency magnetic field (HFMF) irradiation, WINA generates reactive oxygen species (ROS) from hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in mitochondria and drives mitochondrial depolarization through eddy current generation. The depolarization further causes the dissipation of mitochondrial membrane potential (MMP), leading to the release of damage-associated molecular patterns (DAMPs). This process activates dendritic cells, thereby enhancing the effective infiltration of T cells to the brain tumor. Furthermore, transcriptome analysis of brain tumors revealed that key genes such as Cd8a, Ifng, Tnf, and Il1b, which are critical for T cell activation. In whole-brain diffusion MRI, fiber tracing of the M1-TH and S1HL-Cpu tracts was explored after treatment, indicating improved brain function. Combined with immune checkpoint therapy, this approach resulted in antitumor activity and tumor growth inhibition.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102838"},"PeriodicalIF":13.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electron localization engineering to construct Cu single-atom bridges between g-C3N4 layers for regulating third-order nonlinear optical properties 电子局域化工程在g-C3N4层间构建Cu单原子桥以调节三阶非线性光学性质
IF 13.2 1区 材料科学
Nano Today Pub Date : 2025-06-14 DOI: 10.1016/j.nantod.2025.102836
Jing Huang, Kangshuai Geng, Yupei Sun, Yi Wei, Hongwei Hou
{"title":"Electron localization engineering to construct Cu single-atom bridges between g-C3N4 layers for regulating third-order nonlinear optical properties","authors":"Jing Huang,&nbsp;Kangshuai Geng,&nbsp;Yupei Sun,&nbsp;Yi Wei,&nbsp;Hongwei Hou","doi":"10.1016/j.nantod.2025.102836","DOIUrl":"10.1016/j.nantod.2025.102836","url":null,"abstract":"<div><div>The weak van der Waals force between 2D g-C<sub>3</sub>N<sub>4</sub> layers suppresses the charge transfer between layers and hinders the application development in nonlinear optics (NLO) field. Herein, the covalently functionalized g-C<sub>3</sub>N<sub>4</sub> is wet-impregnated into CuCl<sub>2</sub> solution through a post-synthesis strategy, and the engineering of Cu single atoms bridging the 2D layers is achieved through coordination effect of Cu-N. The conjugated modification of 8-aminoquinoline (8-AQ) within layers and the synergistic effect of interlayer Cu single atom bridges induces electron cross plane delocalization, thereby stimulating changes in the higher-order polarizability of medium. The third-order NLO absorption behavior of g-C<sub>3</sub>N<sub>4</sub>-8AQ transitions from saturated absorption (SA) of g-C<sub>3</sub>N<sub>4</sub> to reverse saturated absorption (RSA), and g-C<sub>3</sub>N<sub>4</sub>-8AQ-Cu to exhibits a more significant RSA signal (with a <em>β</em><sub><em>eff</em></sub> of 4.0 × 10<sup>−10</sup> m W<sup>−1</sup>). It is notable that the third-order NLO refractive behavior undergoes a striking transition from self-focusing (g-C<sub>3</sub>N<sub>4</sub> with n<sub>2</sub> of 1.3 × 10<sup>−17</sup> m<sup>2</sup> W<sup>−1</sup> and g-C<sub>3</sub>N<sub>4</sub>-8AQ-18 with n<sub>2</sub> of 3.1 × 10<sup>−17</sup> m<sup>2</sup> W<sup>−1</sup>) to self-defocusing (g-C<sub>3</sub>N<sub>4</sub>-8AQ-18-Cu with n<sub>2</sub> of −3.3 × 10<sup>−17</sup> m<sup>2</sup> W<sup>−1</sup>). This work realizes the cross-layer transfer of charges in g-C<sub>3</sub>N<sub>4</sub>, thereby distorting the electron cloud and making it potentially promising in light-limiting applications as well.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102836"},"PeriodicalIF":13.2,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compact clustering of highly oligomerized anti-DR5 nanobodies effectively drives apoptotic cancer cell death, significantly suppressing tumor growth 高度寡聚的抗dr5纳米体紧密聚集,有效地驱动凋亡癌细胞死亡,显著抑制肿瘤生长
IF 13.2 1区 材料科学
Nano Today Pub Date : 2025-06-11 DOI: 10.1016/j.nantod.2025.102834
Yunjung Kim , Jihyoung Mun , Eojin Kim , Hyungsuk Roh , Soomin Eom , Heejin Jun , Hyo Jeong Kim , Minseung Kim , Jun Pyo Jeon , Sung Ho Park , Duyoung Min , Sebyung Kang
{"title":"Compact clustering of highly oligomerized anti-DR5 nanobodies effectively drives apoptotic cancer cell death, significantly suppressing tumor growth","authors":"Yunjung Kim ,&nbsp;Jihyoung Mun ,&nbsp;Eojin Kim ,&nbsp;Hyungsuk Roh ,&nbsp;Soomin Eom ,&nbsp;Heejin Jun ,&nbsp;Hyo Jeong Kim ,&nbsp;Minseung Kim ,&nbsp;Jun Pyo Jeon ,&nbsp;Sung Ho Park ,&nbsp;Duyoung Min ,&nbsp;Sebyung Kang","doi":"10.1016/j.nantod.2025.102834","DOIUrl":"10.1016/j.nantod.2025.102834","url":null,"abstract":"<div><div>Death receptors (DRs) are attractive targets for cancer therapy due to their tight regulation by apoptosis-inducing ligands and their high expression on many cancer cells. Here, we employ a high affinity anti-DR5 nanobody (aDR5Nb) as a DR5 agonist and generate various oligomeric aDR5Nb clusters with different oligomerization states and arrangements, using a variety of scaffold proteins. Hexameric and higher-oligomeric aDR5Nb clusters efficiently initiate DR5-mediated apoptotic signals in lung and breast cancer cells, leading to significant apoptotic cancer cell death. Compact aDR5Nb clusters containing the same number of aDR5Nb in a cluster exhibit superior cytotoxic effects compared to more spatially dispersed clusters, demonstrating that both the number and compactness of aDR5Nb clusters are critical for driving robust DR5-mediated cancer cell death. Notably, highly compact and oligomerized dodecameric aDR5Nb clusters are required to overcome resistance in TRAIL-resistant lung and breast cancer cells. Compact dodecameric aDR5Nb clusters substantially suppress tumor growth in a TRAIL-resistant lung cancer xenograft model without notable side effects. Our study clearly demonstrates the importance of both oligomerization and the compactness of aDR5Nb clusters in enhancing apoptotic signaling and antitumor activity, offering a promising strategy for improving DR5-mediated cancer therapies by optimizing the nanoscale environment of cancer cells.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102834"},"PeriodicalIF":13.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A nanoscale innate immune multiplier amplifies immunogenic cell death triggered by oxaliplatin via enhancing systemic and trained immunity 纳米级先天免疫倍增器通过增强全身和训练免疫,放大奥沙利铂引发的免疫原性细胞死亡
IF 13.2 1区 材料科学
Nano Today Pub Date : 2025-06-11 DOI: 10.1016/j.nantod.2025.102835
Yang Zhang , Zhicheng Yan , Shuo Geng , Yueheng Wang , Junji Ren , Yunhui Jiang , Liuqing Yang , Wenbing Dai , Hua Zhang , Xueqing Wang , Nan Zheng , Qiang Zhang , Bing He
{"title":"A nanoscale innate immune multiplier amplifies immunogenic cell death triggered by oxaliplatin via enhancing systemic and trained immunity","authors":"Yang Zhang ,&nbsp;Zhicheng Yan ,&nbsp;Shuo Geng ,&nbsp;Yueheng Wang ,&nbsp;Junji Ren ,&nbsp;Yunhui Jiang ,&nbsp;Liuqing Yang ,&nbsp;Wenbing Dai ,&nbsp;Hua Zhang ,&nbsp;Xueqing Wang ,&nbsp;Nan Zheng ,&nbsp;Qiang Zhang ,&nbsp;Bing He","doi":"10.1016/j.nantod.2025.102835","DOIUrl":"10.1016/j.nantod.2025.102835","url":null,"abstract":"<div><div>Inducing immunogenic cell death (ICD) of cancer cells is the key for cytotoxic drugs to improve the synergy with immunotherapy. However, due to the immunosuppressive microenvironment and the cytotoxicity differences of drugs, ICD effects are often insufficient and difficult to effectively and durably activate anti-tumor immune responses. Here, we performed a network meta-analysis (NMA) based on clinical data of gastrointestinal cancer and identified oxaliplatin (Oxp) as an effective ICD-inducing drug. Meanwhile, to overcome the negative effects of immunosuppressive microenvironment on ICD, we constructed a nanoscale innate immune multiplier (NIIM) composed of nano-granulated manganous zoledronate, and designed a systemic delivery strategy to achieve the superposition of innate immune responses from multiple sites and amplify the ICD effect of Oxp. NIIM was first targeted to the tumor tissue, where it concurrently engaged tumor cells and innate immunocytes to reverse the immunosuppressive microenvironment. Following intravenous administration, NIIM was also distributed to the spleen, where it activated Ly6C<sup>+</sup> inflammatory monocytes, directly augmenting the phagocytosis and elimination of tumor cells, and inducing the tumor-killing efficacy by cytotoxic T cells. Additionally, NIIM modulated the composition of hematopoietic progenitor cells in the bone marrow, inducing a durable innate immune response through trained immunity. The superposition of these immune effects allowed NIIM to significantly enhance the efficacy of oxaliplatin in gastrointestinal cancers after only one single injection. In summary, this strategy of simultaneously activating intratumoral, systemic, and trained immunity based on intravenous NIIM provides an effective new approach to amplify ICD of cytotoxic drugs and achieve the efficient synergy of chemotherapy with immunotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102835"},"PeriodicalIF":13.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanostructured heterojunctions for magnetoelectric efficiency enhancement and the wireless electrical stimulation in neurogenesis 纳米结构异质结用于增强磁电效率和神经发生中的无线电刺激
IF 13.2 1区 材料科学
Nano Today Pub Date : 2025-06-06 DOI: 10.1016/j.nantod.2025.102833
Jialu Li , Yusheng Zhang , Xiaoyin Liu , Yuyan Wang , Rong Li , Yiyao Pu , Junzhong Jiang , Jiamei Xiao , Peng Liu , Jie Ding , Dan Wei , Jing Sun , Chengheng Wu , Liangxue Zhou , Roman V. Chernozem , Hongsong Fan
{"title":"Nanostructured heterojunctions for magnetoelectric efficiency enhancement and the wireless electrical stimulation in neurogenesis","authors":"Jialu Li ,&nbsp;Yusheng Zhang ,&nbsp;Xiaoyin Liu ,&nbsp;Yuyan Wang ,&nbsp;Rong Li ,&nbsp;Yiyao Pu ,&nbsp;Junzhong Jiang ,&nbsp;Jiamei Xiao ,&nbsp;Peng Liu ,&nbsp;Jie Ding ,&nbsp;Dan Wei ,&nbsp;Jing Sun ,&nbsp;Chengheng Wu ,&nbsp;Liangxue Zhou ,&nbsp;Roman V. Chernozem ,&nbsp;Hongsong Fan","doi":"10.1016/j.nantod.2025.102833","DOIUrl":"10.1016/j.nantod.2025.102833","url":null,"abstract":"<div><div>Wireless deep brain stimulation mediated by magnetoelectric (ME) nanoparticles (NPs) has emerged as a promising alternative to traditional neuromodulation for neurological disorders. However, it is a great challenge to achieve a highly efficient treatment of neural injuries via limited ME conversion efficiency, which highlights the opportunity for further material optimization. Here, we propose a robust strategy to improve the ME efficiency by introducing Au NPs onto the surface of core<img>shell CoFe<sub>2</sub>O<sub>4</sub>@BaTiO<sub>3</sub> NPs to build Schottky junctions, thereby promoting the separation of electron<img>hole pairs. Moreover, Schottky junctions can be modulated by the piezoelectric field generated by the piezoelectric shell of ME NPs under a magnetic field, allowing electrons to flow continuously. On this basis, we established a wireless ME modulation platform by integrating heterojunction-reinforced ME NPs with a hydrogel matrix that mimics key biochemical and mechanical properties of neural tissue, supporting long-term magnetoelectric stimulation of neural stem cells (NSCs) and promoting their neuronal differentiation <em>in vitro</em>. Furthermore, the therapeutic potential of the ME platform was demonstrated in a traumatic brain injury (TBI) model, in which it significantly enhanced NSC migration and neuronal differentiation, promoted the reconstruction of neural networks, and improved cognitive and memory functions. Overall, this strategy provides new insights for the development of brain stimulation strategies as well as neural tissue repair following injury.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102833"},"PeriodicalIF":13.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inside Back Cover - Graphical abstract TOC/TOC in double column continued from OBC if required, otherwise blank page 封底内-图解摘要TOC/TOC双栏,如果需要,从OBC继续,否则空白页
IF 13.2 1区 材料科学
Nano Today Pub Date : 2025-06-04 DOI: 10.1016/S1748-0132(25)00199-9
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