IF 10.7 1区材料科学

Nano Today Pub Date : 2026-08-01 Epub Date: 2026-07-29 DOI: 10.1016/S1748-0132(26)00170-2

引用次数: 0

Corrigendum to “Amelogenin biomimetic peptides induce MMP-8-responsive enamel remineralization in authentic demineralization-relevant oral environment” [Nano Today 69 (2026) 103071] “Amelogenin仿生肽诱导mmp -8反应性牙釉质在真实脱矿相关口腔环境中的再矿化”的勘误表[Nano Today 69 (2026) 103071]

IF 10.7 1区材料科学

Nano Today Pub Date : 2026-08-01 Epub Date: 2026-07-25 DOI: 10.1016/j.nantod.2026.103133

Shao-Yu Hu, Guo-Yang Xu, Wen-Tao Hu, Yao-Bang Shen, Qiong Nie, Li Dong, Yu-Ying Jiang, Yan Cao, Zhuo-Yue Li, Xi-You Yang, Jun-Xiao Yuan, Hao Wang, Lei Wang

引用次数: 0

Inside Back Cover - Graphical abstract TOC/TOC in double column continued from OBC if required, otherwise blank page 封底内-图解摘要TOC/TOC双栏，如果需要，从OBC继续，否则空白页

IF 10.7 1区材料科学

Nano Today Pub Date : 2026-08-01 Epub Date: 2026-07-29 DOI: 10.1016/S1748-0132(26)00169-6

引用次数: 0

Affinity-driven epirubicin prodrug albumin nanoassemblies for cancer therapy 亲和力驱动的表阿霉素前药白蛋白纳米组件用于癌症治疗

IF 10.7 1区材料科学

Nano Today Pub Date : 2026-08-01 Epub Date: 2026-07-20 DOI: 10.1016/j.nantod.2026.103126

Jiayu Guo, Yuxin Ma, Yashi Zhan, Jiakun Cui, Jialin Xing, Jiaqi Ma, Bingjun Sun, Lingxiao Li

{"title":"Affinity-driven epirubicin prodrug albumin nanoassemblies for cancer therapy","authors":"Jiayu Guo, Yuxin Ma, Yashi Zhan, Jiakun Cui, Jialin Xing, Jiaqi Ma, Bingjun Sun, Lingxiao Li","doi":"10.1016/j.nantod.2026.103126","DOIUrl":"10.1016/j.nantod.2026.103126","url":null,"abstract":"<div><div>The clinical utility of epirubicin (EPI) is limited by its rapid clearance, insufficient tumor accumulation, and severe systemic toxicity. Although albumin-based nanocarriers offer a potential solution, their development is hindered by the inherently weak affinity between EPI and albumin. Here, we reported an affinity-driven prodrug-albumin nanoassembly via a modular design. Specifically, EPI was conjugated to myristic acid (C14) via a pH-sensitive hydrazone linkage to form EPI-C14, which co-assembled with bovine serum albumin (BSA) into stable nanoassemblies (EPI-C14@BSA NPs) with high drug loading and binding efficiency at an optimized ratio. Fatty acid modification markedly enhanced drug-albumin affinity, leading to improved pharmacokinetics compared with free EPI. Upon reaching the tumor site, EPI-C14@BSA NPs responsively released EPI in the acidic microenvironment, inducing potent cytotoxic effects. Benefiting from improved systemic exposure and tumor-selective drug activation, EPI-C14@BSA NPs exhibited superior antitumor efficacy in a 4T1 tumor-bearing mouse model at a high dose, while effectively mitigating body weight loss and systemic toxicity associated with free EPI, thereby achieving a favorable balance between efficacy and safety. This work presented a rational prodrug strategy to enhance drug-carrier affinity, offering a promising approach to expand the utility of albumin-based nanoplatforms for chemotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"70 ","pages":"Article 103126"},"PeriodicalIF":10.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148641012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiofrequency-responsive poly(combretastatin ionic liquid) nanogels for themo-boosting trans-arterial vascular disruption-embolization 射频响应多离子液体（combretastatin离子液体）纳米凝胶用于热增强经动脉血管阻断栓塞

IF 10.7 1区材料科学

Nano Today Pub Date : 2026-08-01 Epub Date: 2026-07-24 DOI: 10.1016/j.nantod.2026.103130

Le Zhao, Bo Sun, Xin Yang, Mengqin Guo, Yan Liu, Chao Liu, Zhihao Su, Chuansheng Zheng, Xiangliang Yang, Yanbing Zhao

{"title":"Radiofrequency-responsive poly(combretastatin ionic liquid) nanogels for themo-boosting trans-arterial vascular disruption-embolization","authors":"Le Zhao, Bo Sun, Xin Yang, Mengqin Guo, Yan Liu, Chao Liu, Zhihao Su, Chuansheng Zheng, Xiangliang Yang, Yanbing Zhao","doi":"10.1016/j.nantod.2026.103130","DOIUrl":"10.1016/j.nantod.2026.103130","url":null,"abstract":"<div><div>Trans-arterial chemoembolization (TACE), a first-line treatment for intermediate-/advanced-stage hepatocellular carcinoma (HCC), is heavily limited by tumor vascular heterogeneity and poor drug penetration. In this study, a temperature/radiofrequency (RF)-responsive poly(ionic liquid) nanogel (poly(<em>N</em>-isopropylacrylamide-<em>b</em>-1-butyl-3-vinylimidazolium combretastatin A4 phosphate), PIV·CA) was designed to achieve thermo-boosting trans-arterial vascular disruption-embolization (TAVDE) via RF-triggered release/penetration promotion of combretastatin A4 phosphate (CA4P) and temperature-sensitive sol-gel phase transition. The RF field shockingly increased the cytotoxicity of PIV·CA by approximately 22-fold, increasing the interaction of CA4P with tubulin and resulting in cell cycle arrest in the G2/M phase via increased suppression of tubulin polymerization. PIV·CA precisely synergizes vascular disruption, arterial embolization and RF ablation, suggesting a potential strategy of RF-energized TAVDE in transarterial therapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"70 ","pages":"Article 103130"},"PeriodicalIF":10.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148641014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wisdom at the interface: Advanced hydrotalcite-based Janus membranes for precision separation of emulsified gear oil 界面上的智慧：先进的基于水滑石的Janus膜用于乳化齿轮油的精确分离

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-06-01 Epub Date: 2026-05-27 DOI: 10.1016/j.nantod.2026.103073

Han Zhang, Fuchao Yang , Zhiguang Guo

{"title":"Wisdom at the interface: Advanced hydrotalcite-based Janus membranes for precision separation of emulsified gear oil","authors":"Han Zhang, Fuchao Yang , Zhiguang Guo","doi":"10.1016/j.nantod.2026.103073","DOIUrl":"10.1016/j.nantod.2026.103073","url":null,"abstract":"<div><div>The efficient and precise separation of emulsified gear oils poses a crucial challenge in the resource recovery of industrial oily wastewater and the recycling of lubricant media. Its environmentally friendly treatment holds substantial engineering significance for promoting the green manufacturing of high - end equipment and facilitating the low - carbon transformation of industries. Traditional separation materials are characterized by limitations such as poor selectivity, insufficient stability, and weak anti - pollution capabilities, rendering them inadequate for complex operational conditions involving intricate emulsified gear oil compositions, dense interfacial films, and high emulsion stability.This review systematically investigates the construction mechanisms, controllable preparation methods, and interfacial modulation characteristics of layered double hydroxides (LDHs, also referred to as hydrotalcites). It also clarifies the asymmetric design principles and construction strategies of Janus membrane interfaces. The focus is on the collaborative construction approaches of LDHs - Janus composite membranes, interfacial coupling effects, and synergistic mechanisms. Additionally, it analyzes the targeted demulsification separation mechanisms of composite membranes and identifies the application bottlenecks and optimization directions of LDHs in specialized emulsion oil systems.Based on these research findings, this review not only lays the theoretical foundation for the structural innovation of high - performance oil - water separation membrane materials and pioneers new design approaches but also provides essential academic support and broad application prospects for the engineering implementation and industrial promotion of precision separation technologies for emulsified gear oils.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"69 ","pages":"Article 103073"},"PeriodicalIF":10.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148183773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Near-infrared photoactivatable semiconducting polymer nanocomplexes with bispecific metabolism interventions for enhanced cancer immunotherapy” [Nano Today 46 (2022) 101600] “具有双特异性代谢干预的近红外光激活半导体聚合物纳米复合物用于增强癌症免疫治疗”的更正[Nano Today 46 (2022) 101600]

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-06-01 Epub Date: 2026-04-15 DOI: 10.1016/j.nantod.2026.103050

Ningyue Yu , Mengbin Ding , Fengshuo Wang , Jianhui Zhou , Xiangyang Shi , Rong Cai , Jingchao Li

引用次数: 0

The dual facets of B cell immunity: From pathogenic drivers to theranostic tools B细胞免疫的双重方面：从致病驱动因素到治疗工具

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-06-01 Epub Date: 2026-05-28 DOI: 10.1016/j.nantod.2026.103085

Wenfeng Zang , Jiajie Peng , Haonan Xing , Yuanyu Huang , Mei Lu

{"title":"The dual facets of B cell immunity: From pathogenic drivers to theranostic tools","authors":"Wenfeng Zang , Jiajie Peng , Haonan Xing , Yuanyu Huang , Mei Lu","doi":"10.1016/j.nantod.2026.103085","DOIUrl":"10.1016/j.nantod.2026.103085","url":null,"abstract":"<div><div>B lymphocytes or B cells are an integral component of the immune system that maintains immune homeostasis. The known function of B cells is their capacity to support humoral immunity through production of antibodies. Additionally, B cells participate in many other key processes such as phagocytosis, antigen presentation, cytokine secretion, and immune regulation. Abnormal B cell activation or dysfunction are implicated in the pathogenesis of various diseases. Given their diverse immune functions, B cell-targeted diagnosis and therapy remain an active area of research. Currently, B cell-targeted monoclonal antibodies or inhibitors, and engineered B-cell therapies have proven promising strategies in eliminating pathogenic cells and restoring immune balance in the clinic. This review elaborately recapitulates the latest understanding of B cell diversity, plasticity and functionality, with particular emphasis in recent insights into strategies for harnessing B cell immunity in rational design of effective and safe B cell theranostic platforms. With the remarkable progress of precision immunology, more in-depth understanding of B cell heterogeneity and functional diversity will open up a new avenue for developing next-generation B cell-based diagnostic and therapeutic tools.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"69 ","pages":"Article 103085"},"PeriodicalIF":10.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148183776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanin-dependent pyroptosis induces selective tumor killing and durable antitumor immune response in melanoma 黑色素依赖性焦亡在黑色素瘤中诱导选择性肿瘤杀伤和持久的抗肿瘤免疫反应

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-06-01 Epub Date: 2026-05-26 DOI: 10.1016/j.nantod.2026.103086

Xingke Tang , Hao Li , Li Li , Bingqin Li , Miao Su , Chaoran Chen , Houjin Jing , Mingda Yang , Meiwan Chen , Xianzhu Yang

{"title":"Melanin-dependent pyroptosis induces selective tumor killing and durable antitumor immune response in melanoma","authors":"Xingke Tang , Hao Li , Li Li , Bingqin Li , Miao Su , Chaoran Chen , Houjin Jing , Mingda Yang , Meiwan Chen , Xianzhu Yang","doi":"10.1016/j.nantod.2026.103086","DOIUrl":"10.1016/j.nantod.2026.103086","url":null,"abstract":"<div><div>Selective eradication of tumor cells while sparing normal cells remains the ultimate goal of cancer therapy. Current molecularly targeted therapies exploit tumor-specific mutations or biomarkers to differentiate malignant from healthy cells. However, interpatient heterogeneity and the dynamic evolution of these targets limit their clinical applicability. To overcome this, we developed a targeted therapy strategy that exploits an intrinsic feature of melanoma: endogenous melanin. We integrated an HSP70 promoter-driven gasdermin E (GSDME) plasmid into a delivery system termed pCHG@iCLAN. Under 808 nm laser irradiation, endogenous melanin generates mild photothermal heating, which specifically activates the heat-inducible HSP70 promoter. This activation triggers GSDME and caspase-3-dependent pyroptosis selectively in melanoma cells, leaving normal cells and other cancer cell types unaffected. In B16-F10 murine models, this targeted therapy achieved 98% tumor inhibition and significantly prolonged survival. When combined with an immune agonist, it also elicited a durable immune memory that protected against tumor rechallenge. This work establishes a paradigm for using inherent tumor features, rather than variable molecular markers, to achieve precise targeted cancer therapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"69 ","pages":"Article 103086"},"PeriodicalIF":10.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148183770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Floating light-responsive multifunctional soft robot for environmental water management 用于环境水管理的浮式光响应多功能软机器人

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-06-01 Epub Date: 2026-05-27 DOI: 10.1016/j.nantod.2026.103082

Yingyi Gan , Bin Wang , Maoxian Wang , Xiaotong Li , Yuan Lu

{"title":"Floating light-responsive multifunctional soft robot for environmental water management","authors":"Yingyi Gan , Bin Wang , Maoxian Wang , Xiaotong Li , Yuan Lu","doi":"10.1016/j.nantod.2026.103082","DOIUrl":"10.1016/j.nantod.2026.103082","url":null,"abstract":"<div><div>Light-driven soft robots have enabled untethered locomotion and stimulus-responsive functions, yet most reported systems remain dominated by a single behavior, with limited actuation orthogonality, weak system reconfigurability, and insufficient task-level integration on complex water surfaces. These limitations are particularly restrictive in confined aquatic environments, where floating solids, oil films, and dissolved pollutants frequently coexist. Here, we report a centimeter-scale floating soft robot that addresses this challenge through wavelength-selective modular integration. The system combines UV-responsive LCE-PDMS actuators for reversible gripping, NIR-responsive GTC/PDMS for Marangoni propulsion and oil adsorption, and xenon-responsive TiO<sub>2</sub>/PAM hydrogel for photocatalytic degradation, enabling decoupled optical control of locomotion, manipulation, and chemical treatment within one untethered platform. The robot can be reconfigured into task-oriented architectures for oil adsorption, solid capture, dye degradation, and integrated remediation. The GTC/PDMS module drives interfacial motion at speeds up to 3.3 cm·s<sup>−1</sup> and provides an oil-loading capacity of 0.13 g·g<sup>−1</sup>, the LCE-PDMS actuator achieves reliable gripping within 20 s across 6–27 mm targets, and the TiO<sub>2</sub>/PAM module reaches 91% methylene blue degradation within 2.5 h. Beyond ideal conditions, the integrated robot retains multimodal remediation capability in saline, alkaline, turbid, and vortex-disturbed environments. This work establishes a system-level strategy for combining orthogonal light actuation, modular reconfiguration, and multimodal remediation in a single floating soft robotic platform for adaptive water-surface cleaning.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"69 ","pages":"Article 103082"},"PeriodicalIF":10.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148183772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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