Nano Today最新文献

Augmenting Tumor Lysis and Immune Response through HIFU-armed Oncolytic Virus Delivery System

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-12-02 DOI: 10.1016/j.nantod.2024.102571

Xifeng Qin , Mingyang Liu , Hu Wu , Boshu Ouyang , Xu Zhao , Xiaomin Su , Ruizhe Xu , Huiwen Liu , Jiayi Wu , Yue Liu , Ting Wang , Onder Ergonul , Füsun Can , Jia Li , Lin Lin , Funan Liu , Zhiqing Pang

{"title":"Augmenting Tumor Lysis and Immune Response through HIFU-armed Oncolytic Virus Delivery System","authors":"Xifeng Qin , Mingyang Liu , Hu Wu , Boshu Ouyang , Xu Zhao , Xiaomin Su , Ruizhe Xu , Huiwen Liu , Jiayi Wu , Yue Liu , Ting Wang , Onder Ergonul , Füsun Can , Jia Li , Lin Lin , Funan Liu , Zhiqing Pang","doi":"10.1016/j.nantod.2024.102571","DOIUrl":"10.1016/j.nantod.2024.102571","url":null,"abstract":"<div><div>Oncolytic viruses (OVs) have hold great promise as a tumor immunotherapy. However, their effectiveness is hindered by the challenge of precise and efficient delivery <em>in vivo</em> and stimulating a robust anti-tumor immune response. In this study, we developed a strategy of high-intensity focused ultrasound (HIFU)-armed oncolytic immunotherapy. It was found that HIFU facilitating efficient delivery of erythrocyte-hijacking OVs to solid tumors and enhancing the penetration of OVs in tumors. Remarkably, HIFU enhanced the oncolytic effect of OVs not only by suppressing the host cell’s ability of virus clearance through downregulating the IFN signaling pathway, but also by enhancing OV replication within tumor cells through upregulating the expression of the oncogene RAS, inducing DNA damage, and promoting OVs-induced autophagy. More importantly, HIFU augmented OVs-mediated anti-tumor immune responses <em>in vivo</em>, leading to remodeling of the tumor microenvironment, resulting in nearly complete tumor regression (97.6 %) within 15 days and 80 % tumor-free status sustained for 120 days. Overall, these findings highlight the potential of HIFU as a novel modality for precise OV delivery, augmented oncolytic effect, and robust immunostimulation in oncolytic immunotherapy of solid tumors.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102571"},"PeriodicalIF":13.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outside Back Cover - Graphical abstract TOC/TOC in double column/Cover image legend if applicable, Bar code, Abstracting and Indexing information

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-12-01 DOI: 10.1016/S1748-0132(24)00426-2

引用次数: 0

Inside Back Cover - Graphical abstract TOC/TOC in double column continued from OBC if required, otherwise blank page

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-12-01 DOI: 10.1016/S1748-0132(24)00425-0

引用次数: 0

Corrigendum to “Engineering catalytic dephosphorylation reaction for endotoxin inactivation” [Nano Today 44 (2022) 101456]

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-12-01 DOI: 10.1016/j.nantod.2024.102525

Meng Gao , Xi Liu , Zhenzhen Wang , Hui Wang , Tristan Asset , Di Wu , Jun Jiang , Qianqian Xie , Shujuan Xu , Xiaoming Cai , Jia Li , Weili Wang , Huizhen Zheng , Xingfa Gao , Nikolai Tarasenko , Benjamin Rotonnelli , Jean-Jacques Gallet , Frédéric Jaouen , Ruibin Li

引用次数: 0

Sequentially amplified integration of catalytic DNA circuits for high-performance intracellular imaging of miRNA and interpretation of mRNA-miRNA signalling pathway

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-12-01 DOI: 10.1016/j.nantod.2024.102563

Mengdi Yu , Yushi Wang , Jinhua Shang , Qingqing Zhang , Yuqian Jiang , Xiaoqing Liu , Fuan Wang

{"title":"Sequentially amplified integration of catalytic DNA circuits for high-performance intracellular imaging of miRNA and interpretation of mRNA-miRNA signalling pathway","authors":"Mengdi Yu , Yushi Wang , Jinhua Shang , Qingqing Zhang , Yuqian Jiang , Xiaoqing Liu , Fuan Wang","doi":"10.1016/j.nantod.2024.102563","DOIUrl":"10.1016/j.nantod.2024.102563","url":null,"abstract":"<div><div>The cascaded catalytic circuits are viable tools for improving the signal gain of biosensors, yet their sensing performance is still limited by the signal leakage from complex biological environment and unsatisfying reaction efficiency from inter-reactants steric hindrance. Herein, we proposed a catalytically localized DNA (CLD) circuit for the accurate and high-efficiency imaging of microRNA (miRNA) in living cells by virtue of the sequentially and successively amplified integration of catalytic DNA circuits. The compact CLD circuit was constructed by integrating two elemental catalytic circuits, cell-responsive EDR module and analyte-sensing CHA module, where CHA module was initially caged in EDR module for eliminating the unwanted off-site and off-target signal leakage. Only by cell-specific messenger RNA (mRNA)-activated EDR operation then the elemental CHA circuit could be successively connected to facilitate the highly efficient intramolecular reaction with low steric hindrance, thus leading to accelerated reaction efficiency for miRNA analyte. The multiple molecular recognition and the spatial self-confinement of the smart CLD circuit enable the accurate and high-efficiency imaging of intracellular miRNA. The interaction network of mRNA and miRNA was then investigated in situ through our CLD circuit, which provides a powerful tool for discovering the underlying signal pathways between these different RNAs in living cells.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102563"},"PeriodicalIF":13.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RVG29-modified oncolytic herpes simplex virus for intracranial tumor treatment

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-30 DOI: 10.1016/j.nantod.2024.102573

Liting Chen , Chen Xu , Hainan Xu , Hongyu Liu , Zihan Ma , Jiahao Liu , Xiaoyu Gao , Wei Lv , Xinze Du , Xiao Zhao , Jing Shi , Keman Cheng , Funan Liu

{"title":"RVG29-modified oncolytic herpes simplex virus for intracranial tumor treatment","authors":"Liting Chen , Chen Xu , Hainan Xu , Hongyu Liu , Zihan Ma , Jiahao Liu , Xiaoyu Gao , Wei Lv , Xinze Du , Xiao Zhao , Jing Shi , Keman Cheng , Funan Liu","doi":"10.1016/j.nantod.2024.102573","DOIUrl":"10.1016/j.nantod.2024.102573","url":null,"abstract":"<div><div>Oncolytic virus therapy for brain tumors has achieved breakthrough progress in clinical applications, yet its potential is severely constrained by the mode of administration-direct intratumoral injection into the cranial cavity. Other administration routes face rapid clearance by neutralizing antibodies and obstacles posed by the blood-brain barrier. Herein, we engineered the oncolytic herpes simplex virus type 2 (OH2) with surface modifications of polyethylene glycol (PEG) and rabies virus glycoprotein 29 (RVG29, a BBB-penetrating peptide from the rabies virus), to form OH2-PEG-RVG. OH2-PEG-RVG could efficiently traversed the blood-brain barrier even in BALB/c mice with pre-existing anti-OH2 antibodies, leading to the accumulation of OH2 in the brain. More importantly, OH2-PEG-RVG maintained blood-brain barrier integrity without causing pathological changes or behavioral abnormalities in mice. Furthermore, OH2-PEG-RVG effectively inhibited brain tumor growth, transforming immunologically \"cold\" tumors into \"hot\" tumors, inducing a robust anti-tumor immune response, and prolonging the survival of the mice. These findings underscore the potential of OH2-PEG-RVG as a multifaceted therapeutic strategy for effective brain tumor treatment, offering insights into addressing blood-brain barrier limitations.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102573"},"PeriodicalIF":13.2,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boosting ubiquitin-proteasome system-mediated androgen receptor degradation and cGAS-STING pathway activation for synergistic prostate cancer therapy by engineered zinc-manganese oxide nanoparticles

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-29 DOI: 10.1016/j.nantod.2024.102560

Linnan Yang , Yi Hu , Hui Peng , Zhengbin Wang , Sixu Chen , Jieying Qian , Yujie Yang , Zhonghua Xu , Jin Wu , Chaozhao Liang , Guilong Zhang , Yunjiao Zhang , Li Zhang

{"title":"Boosting ubiquitin-proteasome system-mediated androgen receptor degradation and cGAS-STING pathway activation for synergistic prostate cancer therapy by engineered zinc-manganese oxide nanoparticles","authors":"Linnan Yang , Yi Hu , Hui Peng , Zhengbin Wang , Sixu Chen , Jieying Qian , Yujie Yang , Zhonghua Xu , Jin Wu , Chaozhao Liang , Guilong Zhang , Yunjiao Zhang , Li Zhang","doi":"10.1016/j.nantod.2024.102560","DOIUrl":"10.1016/j.nantod.2024.102560","url":null,"abstract":"<div><div>Androgen receptor (AR) is an essential target for prostate cancer (PCa) therapy, while required resistance due to AR overexpression/abnormal splicing often leads to therapeutic failure, and how to realize the synergistic therapeutic efficacy for PCa remains a challenge. Herein, a novel paradigm of zinc-manganese oxide nanoparticles (ZMONPs) is rationally engineered, which can cooperate in promoting ubiquitin-proteasome system (UPS)-mediated AR degradation and cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway activation, thereby generating a tumoricidal immune microenvironment to elicit PCa cell death. Upon lysosomal acidolysis, ZMONPs promote zinc ions overload to produce more reactive oxygen species (ROS), which ultimately contribute to UPS-mediated AR degradation and tumoricidal effect. In PCa mouse models, ZMONPs significantly down-regulate the abundance of AR within the tumor microenvironment, further facilitating cGAS-STING signaling pathway activation to secrete C-C motif chemokine ligand 5 (CCL5) and interferon beta (IFN-β), which enhance dendritic cells (DCs) maturation and cytotoxic T lymphocytes (CTLs) infiltration, thus realizing tumor growth inhibition in a cooperative manner. In addition, co-administration of ZMONPs and docetaxel presents notably synergistic therapeutic efficacy. Collectively, this study highlights the favorable effects of ZMONPs on AR degradation-related hormonal therapy and anti-tumor immunity, which may serve as a promising therapeutic strategy for PCa.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102560"},"PeriodicalIF":13.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SNA·SMNP·CBE system: A novel integrative strategy for β-hemoglobinopathies gene therapy SNA-SMNP-CBE 系统：β-血红蛋白病基因治疗的新型综合策略

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-26 DOI: 10.1016/j.nantod.2024.102558

Hongya Cheng , Wenqiao Hui , Hanyue Kang , Zhenni Shi , Jianlei Liu , Xin Wang , Fei Qi , Lin Mao , Huiqian Ding , Rongjian Hu , Nabila Begum , Daoqiang Lu , Dandan Chen , Xinyue Cheng , Miaomiao Wan , Dahai Liu , Hsian-Rong Tseng , Shoudong Ye , Xiaobin Xu , Baowei Zhang , Qian Ban

{"title":"SNA·SMNP·CBE system: A novel integrative strategy for β-hemoglobinopathies gene therapy","authors":"Hongya Cheng , Wenqiao Hui , Hanyue Kang , Zhenni Shi , Jianlei Liu , Xin Wang , Fei Qi , Lin Mao , Huiqian Ding , Rongjian Hu , Nabila Begum , Daoqiang Lu , Dandan Chen , Xinyue Cheng , Miaomiao Wan , Dahai Liu , Hsian-Rong Tseng , Shoudong Ye , Xiaobin Xu , Baowei Zhang , Qian Ban","doi":"10.1016/j.nantod.2024.102558","DOIUrl":"10.1016/j.nantod.2024.102558","url":null,"abstract":"<div><div>Here, we developed and demonstrated a novel integrative system—Silica Nanorods (SNA) substrate cell capture combined with Supramolecular Nanoparticle (SMNP) delivery mediated CBE base editing (SNA·SMNP·CBE)—achieving the synchronization of CD34+HSPCs cell capture and gene editing for β-hemoglobinopathies. First, <em>in vitro</em> study shows it enables efficient and precise modification of BCL11A promoter in CD34+HSPCs, yielding the highly editing efficiency of 50.4 %, thus making an alternative strategy to conventional immunomagnetic cell separation and electroporation transfection system mediated CBE editing (IMS·EP·CBE). Then, we transplanted the edited human CD34+HSPCs into severe combined immunodeficiency (SCID) mice by using intraosseous injection strategy. When compared with conventional IMS·EP·CBE methods, our results showed that significantly higher human HBG expression in the bone marrow and peripheral blood of recipient mice, and long-term engraftment, evidenced from similar gene expression profiles to naïve CD34+HSPCs at 14 weeks. Conclusively, our integrative system—SNA·SMNP·CBE·intraosseous injection—offers an appealing novel way for the unique potential of gene therapy in the clinic application for β-hemoglobinopathies patients.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102558"},"PeriodicalIF":13.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arrays of horizontal semiconducting carbon nanotubes grown from non-metal catalysts prepared by a “thermophoresis-anchoring” synergistic strategy 利用 "热泳-锚定 "协同策略制备的非金属催化剂生长的水平半导体碳纳米管阵列

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-26 DOI: 10.1016/j.nantod.2024.102562

Sizhe Lin , Tao Ye , Xinyu Zhang , Hui Zuo , Linxi Zhu , Xiuxia Wang , Changlong Li , Zhi Yang , Ran Du , Dewu Lin , Yue Hu

{"title":"Arrays of horizontal semiconducting carbon nanotubes grown from non-metal catalysts prepared by a “thermophoresis-anchoring” synergistic strategy","authors":"Sizhe Lin , Tao Ye , Xinyu Zhang , Hui Zuo , Linxi Zhu , Xiuxia Wang , Changlong Li , Zhi Yang , Ran Du , Dewu Lin , Yue Hu","doi":"10.1016/j.nantod.2024.102562","DOIUrl":"10.1016/j.nantod.2024.102562","url":null,"abstract":"<div><div>The fabrication of uncontaminated single-walled carbon nanotube (SWNT) horizontal arrays is crucial for the development of carbon-based nanoelectronics. However, chemical vapor deposition (CVD) using transition metal catalysts, one of the main methods for preparing SWNT arrays, leaves a significant amount of metal impurities. Here, we report a synergistic thermophoresis-anchoring strategy to prepare uniformly dispersed and size-controllable non-metal SiO<sub>x</sub> catalysts for the growth of horizontal SWNT arrays. The pyrolysis of silicon-based precursors generates an abundant supply of SiO<sub>x</sub> particles, which are deposited bottom-up onto the quartz substrate due to the thermal buoyancy induced by a rapid temperature increase. Meanwhile, Surface reconstruction promoted by mechanical force creates numerous anchoring sites on the quartz substrate. This facilitates the capture of catalysts and suppresses their migration and aggregation, thereby promoting the uniform deposition of small-sized catalysts. Consequently, SWNT arrays with a density of 9 tubes per micron are synthesized using these nonmetal SiO<sub>x</sub> catalysts. Importantly, Raman spectroscopy and electrical characterization reveal a semiconductor ratio of up to 94 % for the directly grown SWNT arrays, which is attributed to an in situ etching mechanism within the confined space. This work provides a viable way to promote the practical application of next-generation carbon-based nanodevices.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102562"},"PeriodicalIF":13.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blue phosphorescent solid supramolecular assemblies between hydroxypropyl-β-cyclodextrin and triazine derivatives for achieving multicolor delayed fluorescence 用于实现多色延迟荧光的羟丙基-β-环糊精和三嗪衍生物之间的蓝色磷光固体超分子组装体

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-24 DOI: 10.1016/j.nantod.2024.102561

Xuan Zhao, Xiaolu Zhou, Qingwen Cheng, Yu Liu

{"title":"Blue phosphorescent solid supramolecular assemblies between hydroxypropyl-β-cyclodextrin and triazine derivatives for achieving multicolor delayed fluorescence","authors":"Xuan Zhao, Xiaolu Zhou, Qingwen Cheng, Yu Liu","doi":"10.1016/j.nantod.2024.102561","DOIUrl":"10.1016/j.nantod.2024.102561","url":null,"abstract":"<div><div>Highly efficient blue phosphorescent solid supramolecular assemblies are constructed by three triazine derivatives with different carboxylate substitution positions (TAB, TAC and TAD), hydroxypropyl-β-cyclodextrin (HPCD) and polyvinyl alcohol (PVA). The encapsulation of HPCD to TAB/C/D effectively promotes phosphorescence lifetimes and quantum yields of the guests by the host-guest interaction and hydrogen bonds suppressing the nonradiative decays. Impressively, TAD-HPCD/PVA with blue phosphorescence boasts an ultrahigh phosphorescence quantum yield (Φ<sub>P</sub>) of 71.65 %. By further separately doping with fluorescent dyes Fluorescein sodium, Rhodamine B and Sulfo-Cyanine5, supramolecular polymeric films with water responsiveness, regulable lifetimes and multicolor delayed fluorescence are obtained via triplet-to-singlet and singlet-to-singlet Förster resonance energy transfer. Polymeric phosphorescence supramolecular materials mediated by HPCD are desirable for optical anti-counterfeiting patterns and information encryption.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"60 ","pages":"Article 102561"},"PeriodicalIF":13.2,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0