Nano Today最新文献

{"title":"Biomimetic metal-phenolic network-coated elastin-like polypeptide micelles as an immunogenic cell death inducer for orthotopic glioma sonodynamic-chemodynamic-immune therapy","authors":"Zhiqiang Wang ,&nbsp;Yunqi Guo ,&nbsp;Gaoming Li ,&nbsp;Honghua Guo ,&nbsp;Yanying Li ,&nbsp;Jinxia Wang ,&nbsp;Kangan Li ,&nbsp;Serge Mignani ,&nbsp;Mingwu Shen ,&nbsp;Elisabeth Garanger ,&nbsp;Sébastien Lecommandoux ,&nbsp;Xiangyang Shi","doi":"10.1016/j.nantod.2025.102810","DOIUrl":"10.1016/j.nantod.2025.102810","url":null,"abstract":"<div><div>Development of a theranostic nanomedicine to tackle orthotopic glioma remains to be challenging due to the difficulties of blood-brain barrier crossing and integration of different theranostic modalities. Herein, we report the design of biomimetic macrophage membrane (MM)-camouflaged metal-phenolic network (MPN)-coated micelles formed by amphiphilic elastin-like polypeptide (ELP)-chlorin e6 (Ce6) conjugates. We show that the MPN formed by assembly of Mn(II) and tannic acid (for short, TM) enables stable coating of the micelles, and the prepared Ce6-ELP@TM/MM exhibits good water dispersibility with a mean size of 67.8 nm. Under the tumor microenvironment condition, the Ce6-ELP@TM/MM could fast release Mn^2 + to generate reactive oxygen species (ROS) and facilitate Ce6 (a sonosensitizer) to generate singlet oxygen upon ultrasound irradiation, thereby killing cancer cells to induce immunogenic cell death (ICD) through chemodynamic/sonodynamic therapy. Moreover, the ROS-caused DNA damage could combine with Mn²⁺ to activate the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway of cancer cells, thus synergizing ICD to trigger enhanced antitumor immune responses to tackle an orthotopic mouse glioma model thanks to the MM-rendered BBB crossing and Mn²⁺-facilitated magnetic resonance imaging. The developed Ce6-ELP@TM/MM could be used as an ICD inducer to facilitate sonodynamic/chemodynamic/immune therapy of glioma or other tumor types.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102810"},"PeriodicalIF":13.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144137757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering hydroxyapatite nanocrystals for cancer nanomedicine through ion substitution: Advances and prospects","authors":"Gerardo Martin Quindoza III ,&nbsp;Takuma Watanabe ,&nbsp;Hayato Laurence Mizuno ,&nbsp;Vincent Irawan ,&nbsp;Yasutaka Anraku ,&nbsp;Toshiyuki Ikoma","doi":"10.1016/j.nantod.2025.102816","DOIUrl":"10.1016/j.nantod.2025.102816","url":null,"abstract":"<div><div>Cancer nanomedicine bridges cancer biology and nanotechnology to enhance diagnostic accuracy and therapeutic efficacy across various cancer modalities, ultimately aiming to improve patient outcomes and survival. Numerous nanomaterials have been explored for cancer nanomedicine; however, most suffer from systemic toxicity and severe side effects. Recently, hydroxyapatite (HAp), the primary inorganic component of bones and teeth, has emerged as a promising nanoplatform for cancer diagnosis and treatment, owing to its inherent biocompatibility and excellent biodistribution. Moreover, its capacity for ion substitutions has further expanded its potential, enhancing their existing properties and introducing new functionalities that are beneficial for cancer nanomedicine. With the growing interest in ionic substituted HAp nanocrystals, summarizing significant findings and mapping out the field’s current progress is imperative. This review examines recent literature on their applications in cancer diagnostics and therapeutics, as well as in theranostics. Key advancements were identified and outlined, and insights into prospective opportunities to guide future research were explored. This review highlights the immense potential of ionic substituted HAp nanosystems as a versatile and promising platform, paving the way for the development of safer and more effective nanomedicine strategies.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102816"},"PeriodicalIF":13.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing intranasally administered electro-responsive nanodrugs for rapid epilepsy treatment","authors":"Wei Shu ,&nbsp;Yue Jiang ,&nbsp;Shijin Li ,&nbsp;Jian Li ,&nbsp;Xueting Pan ,&nbsp;Changyong Wang ,&nbsp;Hai Wang ,&nbsp;Tao Yu","doi":"10.1016/j.nantod.2025.102808","DOIUrl":"10.1016/j.nantod.2025.102808","url":null,"abstract":"<div><div>Epilepsy is a prevalent neurological disorder, with antiepileptic drugs serving as the cornerstone of clinical treatment. However, oral antiepileptic drugs are limited by issues such as low absorption rates, poor bioavailability, and significant toxic side effects. Although nanodrug delivery systems have shown considerable promise in improving drug efficacy and minimizing side effects, they are hindered by biological barriers, particularly the blood-brain barrier (BBB). Intranasal administration of nanodrugs presents a distinct advantage, as it can bypass the BBB and deliver drugs directly to the brain with rapid absorption, making it especially suitable for the treatment of acute epilepsy and status epilepticus. In response to this need, we have designed and synthesized an electrically responsive nanodrug for intranasal delivery that releases the antiepileptic drug in response to abnormal electrical activity during seizures. By capitalizing on the fast brain-targeting capability of intranasal administration, these nanoparticles quickly penetrate the brain and react to the irregular electrical currents generated by seizures, facilitating rapid drug release. This innovative approach provides a timely and effective means of alleviating acute epilepsy and status epilepticus, offering a rapid, targeted strategy for delivering antiepileptic drugs.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102808"},"PeriodicalIF":13.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144137758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Au&WO3 heterojunctions against multidrug-resistant bacteria","authors":"Pai Zhang ,&nbsp;Ruitao Cha ,&nbsp;Yanxue Si ,&nbsp;Huize Luo ,&nbsp;Qianqian Lin ,&nbsp;Jiamin Qin ,&nbsp;Hao Tang ,&nbsp;Fengshan Zhou ,&nbsp;Xiaohui Wang ,&nbsp;Peng Jiang ,&nbsp;Xingyu Jiang","doi":"10.1016/j.nantod.2025.102813","DOIUrl":"10.1016/j.nantod.2025.102813","url":null,"abstract":"<div><div>Wound infections caused by multidrug-resistant (MDR) Gram-negative bacteria remain a significant medical challenge. Existing treatments, including antibiotics, antimicrobial peptides, and nanomaterials, are limited by drug resistance and toxicity. It is urgent to develop an effective alternative agent for treatment of infected wound. Here, we synthesized Au&amp;WO₃ heterojunctions <em>via</em> a hydrothermal method and NaBH₄ reduction to address MDR bacterial infections. We characterized the structure of Au&amp;WO₃ heterojunctions by TEM, EDS, and zeta potential. Mechanistically, The enhanced bacterial activity could arise from synergistic effects of membrane disruption by Au nanoparticles and replacement of the molybdenum factor by W^6 + ions. The Au₁&amp;WO₃ heterojunction had a minimum inhibitory concentration (MIC) of 12 µg/mL against MDR <em>E. coli</em>, outperforming individual Au nanoparticles and WO₃ nanorods. <em>In vitro</em>, Au₁&amp;WO₃ induced M2 macrophage polarization, demonstrating strong anti-inflammatory activity. The PG-Au₁&amp;WO₃ membranes exerted excellent antibacterial and anti-inflammation properties with good biocompatibility, promoting wound healing in MDR <em>E. coli</em>-infected wound models. The Au&amp;WO₃ heterojunctions highlight their potential as a promising wound dressing for MDR infection treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102813"},"PeriodicalIF":13.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidized cholesterol-doped biomimetic pulmonary surfactant nanocarriers for enhanced pulmonary vaccine delivery","authors":"Meng-Qian Zhang ,&nbsp;Hui-Ping Wen ,&nbsp;Yi-Fan Wang ,&nbsp;Ai-Xin Ma ,&nbsp;Jin-Wei Bu ,&nbsp;Yang-Yang Liu ,&nbsp;Shu-Lin Liu ,&nbsp;Zhi-Gang Wang","doi":"10.1016/j.nantod.2025.102814","DOIUrl":"10.1016/j.nantod.2025.102814","url":null,"abstract":"<div><div>Pulmonary vaccines are considered to have the potential to trigger the respiratory immune system, closely mimicking the natural entry process of pathogens and providing strong viral protection. To improve the immunogenicity of pulmonary vaccines, we introduced a potent delivery system: bioinspired pulmonary surfactant nanocarriers (BPSNs) doped with oxidized cholesterol, specifically 7-ketocholesterol (7-KC). Our study revealed that these nanocarriers, leveraging natural lung surfactant lipids, precisely target lung macrophages with superb biocompatibility. The delivery of a broad-spectrum influenza HA antigen (HA@BPSN) and a ZBP1-activating adjuvant (CBL0137) (CBL@BPSN) <em>via</em> BPSNs, effectively elicited potent immune responses without impairing surfactant functions. Compared to clinically validated traditional inactivated vaccines and the MF59 adjuvant, HA@BPSN and CBL@BPSN induced nearly a 10-fold increase in antibody titers and significantly enhanced CD4⁺ and CD8⁺ T cell responses. This nanovaccine approach showcases superior, broad-spectrum immunoprotection against diverse influenza strains, underscoring BPSN's potential as an effective respiratory vaccine delivery platform and paving the way for refined vaccine design and personalized treatments.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102814"},"PeriodicalIF":13.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes-incorporated biomaterials boost cancer immunotherapy","authors":"Yuechong Li ,&nbsp;Jiazhen Yang ,&nbsp;Songjie Shen ,&nbsp;Jianxun Ding","doi":"10.1016/j.nantod.2025.102805","DOIUrl":"10.1016/j.nantod.2025.102805","url":null,"abstract":"<div><div>Cancer immunotherapy has achieved significant advancements, generating substantial and sustained anti-cancer responses. However, emerging approaches, such as immune checkpoint blockade, chimeric antigen receptor-T cell therapy, and tumor vaccines, have shown limited efficacy against solid tumors. A significant challenge is immune evasion, in which tumor cells trigger insufficient immune responses and create immunosuppressive microenvironments. Exosomes-incorporated biomaterials combine the benefits of both biomaterials and exosomes, overcoming their limitations. These platforms are enriched with tumor-specific antigens, possess targeted delivery capabilities, and exhibit high permeability across biological barriers. As a result, they stimulate robust immune responses against tumors and reverse immunosuppressive microenvironments, providing a promising strategy for cancer immunotherapy. This review covers the preparation methods for exosomes-incorporated biomaterials and highlights their roles in various immune processes, including inducing immunogenic cell death of tumor cells, enhancing antigen presentation, regulating effector T cell responses, and inhibiting immunosuppressive cells, such as regulatory T cells, tumor-associated macrophages, and myeloid-derived suppressor cells. These versatile nanoplatforms have the potential to enhance cancer immunotherapy and show promise for clinical application, though challenges remain for their clinical translation.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102805"},"PeriodicalIF":13.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel hypocrellin B derivative for photodynamic therapy-driven cancer immunotherapy via triggering immunogenic cell death","authors":"Jixing Cheng ,&nbsp;Jinxia Li ,&nbsp;Jiasheng Wu ,&nbsp;Weiyan Kang ,&nbsp;Kaijie Feng ,&nbsp;Yue You ,&nbsp;Chuqi Wan ,&nbsp;Yiting Zheng ,&nbsp;Liang Yan ,&nbsp;Ru Liu ,&nbsp;Feng Zhao ,&nbsp;Yunhui Li","doi":"10.1016/j.nantod.2025.102809","DOIUrl":"10.1016/j.nantod.2025.102809","url":null,"abstract":"<div><div>The natural photosensitizer hypocrellin B (HB) exhibits restricted absorption within the 650–900 nm therapeutic window thereby impeding its clinical translation. This work synthesizes chemical derivative (HB1) from HB to address its restricted therapeutic-window absorption. Upon 660 nm laser irradiation, HB1 localizes to lysosomes, inducing membrane permeabilization and immunogenic cell death (ICD) while concurrently enhancing dendritic cell (DC) maturation and phagocytosis in vitro through photodynamic therapy (PDT). By further co-encapsulating HB1 and the immunoadjuvant R837 in Poly(lactic-co-glycolic acid) (PLGA) nanoparticles, HB1 induces ICD to release tumor antigens that synergize with R837-mediated immune stimulation, achieving potent antitumor effects via enhanced CD8⁺/CD4⁺ T cell infiltration and DC activation. Furthermore, prophylactic administration of PDT-generated tumor lysates combined with R837 primes antitumor immunity and delays tumor progression. These results substantiate the clinical potential of HB1 for photodynamic immunotherapy and suggest a promising strategy for developing personalized PDT vaccines against tumor recurrence. The approach leverages surgically resected tumor tissues to prepare tumor-specific vaccines, providing insights for clinical translation in cancer immunotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102809"},"PeriodicalIF":13.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PM@DCm nanohybrid-mediated pleiotropic antigen presentation for enhanced melanoma immunotherapy","authors":"Zhongsheng Xu ,&nbsp;Xiaojing He ,&nbsp;Ranran Luo ,&nbsp;Chenxi Zhang ,&nbsp;Zening Zhang ,&nbsp;Pengchen Ren ,&nbsp;Jingjing Zhang ,&nbsp;Xiaoyuan Chen ,&nbsp;Yun Liu","doi":"10.1016/j.nantod.2025.102811","DOIUrl":"10.1016/j.nantod.2025.102811","url":null,"abstract":"<div><div>Melanoma, an aggressive cancer with poor prognosis, benefits only minimally from the current immunotherapies. To address these therapeutic shortcomings, achieving efficient antigen presentation is pivotal for robust tumor-specific T-cell activation and durable antitumor immunity. Here, a multifunctional nanohybrid (denoted as PM@DCm) with activated DC membrane-coated, platinum-embedded, hollow manganese-based nanohybrid is developed, which can effectively proceed antigens presentation. The core of multispiked platinum-manganese oxide (termed as Pt@MnO₂) functions dually as a Stimulator of Interferon Genes (STING) agonist and an inducer of immunogenic cell death (ICD) in response to the tumor microenvironment, triggering inflammatory cytokine and actionable tumor antigens release. These events facilitate <em>in-situ</em> DC maturation, improving antigen uptake and presentation to T cells. Simultaneously, the DC-mimetic structure of PM@DCm retains critical costimulatory markers, MHC class I antigen complexes, and chemokine receptors, effectively simulating the functionality of mature DCs. This dual mechanism ensures robust pleiotropic antigen cross-presentation and cytotoxic T-cell priming. As a result, this PM@DCm nanohybrid significantly suppresses tumor growth and metastasis, elicits robust antitumor immunity, and shows strong prophylactic potential. This novel strategy leverages the synergy between mimicking mature DCs and promoting <em>in-stiu</em> DC maturation, delivering pleiotropic antigen presentation for enhanced melanoma immunotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102811"},"PeriodicalIF":13.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A rabies mRNA vaccine provides a rapid and long-term immune response in mice” [Nano Today 53 (2023) 102038]","authors":"Jinrong Long ,&nbsp;Changxiao Yu ,&nbsp;Yiming Cao ,&nbsp;Yiqi Miao ,&nbsp;Huisheng Sun ,&nbsp;Zhen Zhang ,&nbsp;Jierui Mai ,&nbsp;Xin Wang ,&nbsp;Yingying Mao ,&nbsp;Hongwei Li ,&nbsp;Jing Yang ,&nbsp;Shengqi Wang","doi":"10.1016/j.nantod.2025.102807","DOIUrl":"10.1016/j.nantod.2025.102807","url":null,"abstract":"","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102807"},"PeriodicalIF":13.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ nanometer-resolution strain and orientation mapping for gas-solid reactions via precession-assisted four-dimensional scanning transmission electron microscopy","authors":"Yongwen Sun ,&nbsp;Ying Han ,&nbsp;Dan Zhou ,&nbsp;Athanassios S. Galanis ,&nbsp;Alejandro Gomez-Perez ,&nbsp;Ke Wang ,&nbsp;Stavros Nicolopoulos ,&nbsp;Hugo Pérez-Garza ,&nbsp;Yang Yang","doi":"10.1016/j.nantod.2025.102784","DOIUrl":"10.1016/j.nantod.2025.102784","url":null,"abstract":"<div><div>Chemomechanical interactions in gas or liquid environments are crucial for the functionality and longevity of various materials used in sustainable energy technologies, such as rechargeable batteries, water-splitting catalysts, and next-generation nuclear reactors. A comprehensive understanding of nanoscale strain evolution involved in these processes can advance our knowledge of underlying mechanisms and facilitate material design improvements. However, traditional microscopy workflows face challenges due to trade-offs between field of view (FOV), spatial resolution, temporal resolution, and electron beam damage, particularly in gas or liquid environments. Here, we demonstrate <em>in situ</em> nanometer-resolution strain and orientation mapping in a temperature-controlled gas environment with a large FOV. This is achieved by integrating a microelectromechanical system (MEMS)-based closed-cell TEM holder, precession-assisted four-dimensional scanning transmission electron microscopy (4D-STEM), and a direct electron detector (DED). Using the strain evolution during zirconium initial oxidation as a case study, we first outline critical strategies for focused ion beam (FIB) gas-cell sample preparation and gas-phase TEM workflows to enhance experimental success. We then show that integrating DED with precession electron diffraction (PED) and optimizing gas pressure substantially improve the quantity and quality of the detected Bragg peaks in nano-beam electron diffraction (NBED) patterns, enabling more precise strain and orientation measurements. Furthermore, we introduce a practical protocol to pause the reactions, allowing sufficient time for 4D-STEM data collection while ensuring the temporal resolution needed to resolve material dynamics. Our methodology and workflow provide a robust framework for quantitative analysis of chemomechanical evolutions in materials exposed to gas or liquid environments, paving the way for improved material design in energy-related applications.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102784"},"PeriodicalIF":13.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}