Nano Today最新文献_第2页

Modular arborized fog harvesting device with coordinated mechanism of capture and transport 具有捕捉和运输协调机制的模块化芯轴采雾装置

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-23 DOI: 10.1016/j.nantod.2024.102557

Huayang Zhang , Shangzhen Xie , Guangyi Tian , Yihang Zhang , Zhiguang Guo

{"title":"Modular arborized fog harvesting device with coordinated mechanism of capture and transport","authors":"Huayang Zhang , Shangzhen Xie , Guangyi Tian , Yihang Zhang , Zhiguang Guo","doi":"10.1016/j.nantod.2024.102557","DOIUrl":"10.1016/j.nantod.2024.102557","url":null,"abstract":"<div><div>With global water scarcity a growing problem, fog harvesting technology has emerged as an effective solution. Industrial development and population growth have exacerbated the need for efficient, dismantlable, and assembled fog harvesting devices, as well as the requirement to optimize the droplet capture-transport relationship. In this study, a novel modular bionic 3D tree-like structure for fog harvesting system (3D-TSFHS) was developed to achieve rapid droplet transport by means of Nepenthes-inspired superslip leaves (SSLs). In addition, aluminum (Al) cones with superhydrophilic and superhydrophobic (SHL-SHB) patterns were prepared to enhance the droplet capture efficiency by drawing on the special wettability and structural features of various plants and animals such as cactus, spider silk, desert beetles, lizards and camphor leaves. This artificial design significantly enhances the overall capture and transport relationship. The resulting embedded superslip leaves Al cone fog harvesting (E-SLAC-FH) dramatically improves the fog harvesting efficiency and exhibits excellent durability. Assembling this fog harvesting into a 3D-TSFHS achieves a high fog harvesting efficiency of 0.462 g∙cm<sup>−2</sup>∙min<sup>−1</sup>. The system's modular design and its exceptional durability ensure its potential for a wide range of applications in a variety of real-world scenarios.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"60 ","pages":"Article 102557"},"PeriodicalIF":13.2,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic advances of magnetic nanomaterials in chronic wound healing 磁性纳米材料在慢性伤口愈合方面的治疗进展

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-23 DOI: 10.1016/j.nantod.2024.102554

Jingyi Li , Yaqi Yang , Guofang Zhang , Jianfei Sun , Yang Li , Bing Song

{"title":"Therapeutic advances of magnetic nanomaterials in chronic wound healing","authors":"Jingyi Li , Yaqi Yang , Guofang Zhang , Jianfei Sun , Yang Li , Bing Song","doi":"10.1016/j.nantod.2024.102554","DOIUrl":"10.1016/j.nantod.2024.102554","url":null,"abstract":"<div><div>Millions of patients worldwide suffer from chronic and non-healing wounds, leading to hospitalizations, infections, and even fatalities. Despite advances in clinical therapies, wound management remains a significant challenge due to the complex wound environment and increasing antibiotic resistance. Consequently, there is an urgent need for innovative strategies to address chronic wound treatment. Among the emerging approaches, nanomaterial-based therapeutic systems, especially magnetically responsive strategies, are gaining considerable attention. Upon exposure to an external magnetic field, magnetic nanomaterials (MNMs) can induce electromagnetic, magnetothermal, and magnetomechanical effects at the wound site. Additionally, compared with other exogenous stimuli-responsive therapies, magnetic fields offer distinct advantages, including non-invasiveness, deep tissue penetration, and high sensitivity for remote control and actuation of cells. In this review, we first outline the fundamental properties, design strategies, and biological mechanisms of MNMs and discuss their various applications in chronic wound therapy, such as antibacterial effects, magnetothermal therapy, controlled drug delivery, mechanical cell manipulation, wireless electrical stimulation, and dual-stimulation approaches. We then highlight recent advancements in MNMs for wound monitoring and management, including magnetic nanorobots and “smart dressings”. Finally, we offer our insights on the current challenges of MNMs and propose future directions to enhance their clinical translation. Overall, this review emphasizes the potential of magnetic nanomaterial-based therapeutic systems to transform the landscape of chronic wound management.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"60 ","pages":"Article 102554"},"PeriodicalIF":13.2,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking biological barriers: Engineering polymeric nanoparticles for cancer therapy 打破生物障碍：用于癌症治疗的工程聚合物纳米粒子

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-22 DOI: 10.1016/j.nantod.2024.102552

Elmer Austria Jr. , Marcela Bilek , Pegah Varamini , Behnam Akhavan

{"title":"Breaking biological barriers: Engineering polymeric nanoparticles for cancer therapy","authors":"Elmer Austria Jr. , Marcela Bilek , Pegah Varamini , Behnam Akhavan","doi":"10.1016/j.nantod.2024.102552","DOIUrl":"10.1016/j.nantod.2024.102552","url":null,"abstract":"<div><div>Polymeric nanoparticles (PNPs) have evolved over the past few decades as promising vehicles to deliver drugs to treat cancer. However, their clinical application remains limited mainly due to several biological obstacles. These include rapid clearance from the bloodstream, complex hemorheological dynamics, suboptimal biodistribution, limited tumor accumulation and extravasation, inefficient cellular internalization and trafficking, and offsite toxicity. How can we carefully tune the physicochemical properties of PNPs to break these barriers? This review answers this question by comprehensively and critically examining recent advances and trends in engineering the physicochemical properties of PNPs to enhance their efficacy in cancer drug delivery. It sheds light on the underpinning mechanisms regulated by size, shape, and surface chemistry critical in overcoming heterogeneous biological barriers. Synergistic effects and the interplay between these physicochemical properties are discussed in detail. The types of PNPs, based on form, morphology, and fabrication strategies, are critically reviewed and evaluated according to their physicochemical properties, which directly impact the efficacy of the drug delivery systems and their fate upon administration. The review concludes by proposing design principles and future research directions to enhance the clinical translation of PNPs and their advancement towards more effective cancer treatments.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"60 ","pages":"Article 102552"},"PeriodicalIF":13.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed ion-electron conductive materials: A path to higher energy density all-solid-state lithium-ion batteries 混合离子电子导电材料：通往能量密度更高的全固态锂离子电池之路

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-22 DOI: 10.1016/j.nantod.2024.102556

Abdulkadir Kızılaslan , Recep Kızılaslan , Akira Miura , Kiyoharu Tadanaga

{"title":"Mixed ion-electron conductive materials: A path to higher energy density all-solid-state lithium-ion batteries","authors":"Abdulkadir Kızılaslan , Recep Kızılaslan , Akira Miura , Kiyoharu Tadanaga","doi":"10.1016/j.nantod.2024.102556","DOIUrl":"10.1016/j.nantod.2024.102556","url":null,"abstract":"<div><div>The cathode of conventional lithium-ion batteries(LIBs) consist of three components including active materials, binders, and electron conductive agents. Binders and conductive agents, which are not directly involved in Faradaic reactions, should be minimized to incorporate more active materials into the electrode. Unlike conventional LIBs, in all-solid-state batteries(ASSBs) - considered as the next-generation batteries-, there is no liquid electrolyte to impart ionic conductivity through wetting the electrodes. Therefore, cathodes for ASSBs require both ion and electron-conducting additives to facilitate charge transport which complicates the preparation of the cathode with intimate triple contact between active material, ion conductive agent and electron conductive agent. In this perspective, mixed ion-electron conductive(MIEC) materials can be regarded as intrinsic ion-electron conductors for electrodes to ease the cathode preparation, boost gravimetric/volumetric energy density, and dig the path to <em>monocomponent</em> electrodes -solely active materials-. This review covers the potential of MIEC materials to be utilized as active material, binder, interlayer, and conductive scaffold to boost the electrochemical performance of solid-state LIBs. Besides, the potential of ASSBs with monocomponent electrodes was evaluated from the perspective of MIEC materials. Moreover, the feasibility of 2D structures were evaluated as MIEC materials for the ASSB electrodes. The concept of MIEC was not be confined to intrinsic MIEC materials but the materials that turned into MIEC by compositing, doping or heat-treatment were considered as MIEC materials in this study.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"60 ","pages":"Article 102556"},"PeriodicalIF":13.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smart hydrogel dressing for machine learning-enabled visual monitoring and promote diabetic wound healing 智能水凝胶敷料可通过机器学习进行视觉监控，促进糖尿病伤口愈合

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-22 DOI: 10.1016/j.nantod.2024.102559

Duanyu Deng , Lihua Liang , Kaize Su , Han Gu , Xu Wang , Yan Wang , Xiangcun Shang , Wenhuan Huang , Henghui Chen , Xiaoxian Wu , Wing-Leung Wong , Dongli Li , Kun Zhang , Panpan Wu , Keke Wu

{"title":"Smart hydrogel dressing for machine learning-enabled visual monitoring and promote diabetic wound healing","authors":"Duanyu Deng , Lihua Liang , Kaize Su , Han Gu , Xu Wang , Yan Wang , Xiangcun Shang , Wenhuan Huang , Henghui Chen , Xiaoxian Wu , Wing-Leung Wong , Dongli Li , Kun Zhang , Panpan Wu , Keke Wu","doi":"10.1016/j.nantod.2024.102559","DOIUrl":"10.1016/j.nantod.2024.102559","url":null,"abstract":"<div><div>Diabetic wounds are complex complications characterized by long-term chronic inflammation, vascular damage, and difficulties in healing. Monitoring wound pH can serve as an early warning system for infection risk and enhance wound management by tracking changes in wound pH. In this study, a machine learning-assisted analysis smart hydrogel as wound dressing was developed by utilizing a double cross-linked network hydrogel of gelatin methacrylate (GelMA) and chitosan methacrylate (CMCSMA) as the matrix, a compound of cobalt-gallic acid based metal-phenolic nanoparticles (GACo MPNs) as the active ingredients, and phenol red as the pH indicator. This smart hydrogel exhibits excellent injection performance, shape adaptability and mechanical strength. Besides, a series of <em>in vitro</em> experiments demonstrated the favorable biocompatibility and bioactivity of GelMA/CMCSMAP-GACo hydrogel, encompassing its antibacterial, anti-inflammatory, antioxidant, and angiogenic properties. <em>In vivo</em> experiments show that this hydrogel significantly improved the repair of diabetic wounds in mice. Interestingly, the hydrogel exhibited unique visual pH monitoring properties, which can be seamlessly integrated with a smartphone for image visualization and further enable reliable wound pH assessment using machine learning algorithms to enhance wound management based on wound pH. Overall, this study presented a comprehensive regenerative strategy for the management of diabetic wounds.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"60 ","pages":"Article 102559"},"PeriodicalIF":13.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural-based UV-shielding additives to protect photosensitive pesticides: Production of nanoparticles from the co-self-assembly of lignin and tannin 保护光敏农药的天然紫外线屏蔽添加剂：利用木质素和单宁的共自组装生产纳米颗粒

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-16 DOI: 10.1016/j.nantod.2024.102550

Ya Ma , Javier Remón , Lingjuan Luo , Wei Ding , Zhicheng Jiang , Bi Shi

{"title":"Natural-based UV-shielding additives to protect photosensitive pesticides: Production of nanoparticles from the co-self-assembly of lignin and tannin","authors":"Ya Ma , Javier Remón , Lingjuan Luo , Wei Ding , Zhicheng Jiang , Bi Shi","doi":"10.1016/j.nantod.2024.102550","DOIUrl":"10.1016/j.nantod.2024.102550","url":null,"abstract":"<div><div>This work explores the development of a renewable, carbon-neutral, light-colored UV-shielding film to protect photosensitive pesticides from solar radiation, as these chemicals are easily degraded under UV light, substantially reducing their efficiency and causing soil and water pollution. The abundant benzene rings in lignin and phenolic hydroxyls in tannin boosted the co-self-assembly of lignin and tannin into composite nanospheres by the simultaneous π-π stacking and H-bonding interactions between these two biopolymers. These lignin-tannin (LT) composite nanoparticles were used as natural UV-shielding additives to coat a poly-vinyl-alcohol (PVA) film, endowing the PVA-LT film with an excellent UV-shielding ability (>95 % efficiency) due to the strong π-π stacking and concentrated phenolic hydroxyls. Typical photosensitive pesticides covered with the PVA-LT film significantly increased their remaining rate by 1.5 times compared to those under the uncoated film. Besides, intensive intermolecular hydrogen bonds were generated between PVA and the abundant phenolic hydroxyl groups exposed on the hydrophilic shell of the LT coating, enhancing the mechanical properties and water vapor retention of the composite film. Our biodegradable composite film derived from natural plant extracts not only protected photosensitive pesticides from UV irradiation but also allowed the transmission of visible light to guarantee the photosynthesis process of crops.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"60 ","pages":"Article 102550"},"PeriodicalIF":13.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ atomic observation of transformation twinning in nanocrystals 原位原子观测纳米晶体中的转化孪晶

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-16 DOI: 10.1016/j.nantod.2024.102547

Qiubo Zhang , Hui Dong , Amy Ren , Yifan Nie , Haimei Zheng

{"title":"In situ atomic observation of transformation twinning in nanocrystals","authors":"Qiubo Zhang , Hui Dong , Amy Ren , Yifan Nie , Haimei Zheng","doi":"10.1016/j.nantod.2024.102547","DOIUrl":"10.1016/j.nantod.2024.102547","url":null,"abstract":"<div><div>The formation of twinning in nanocrystals impacts their physical and chemical properties. However, the pathways of transformation twinning triggered by an external stimulus is not well-understood. Here, we investigated the transformation twinning of face-centered cubic (FCC) metal nanocrystals under electron beam irradiation, utilizing transmission electron microscopy (TEM) with high spatiotemporal resolution. We found that a bi-crystal twin can form through swap motion as well as via a structural destruction-repair mechanism. The destruction-repair of crystal structure during twinning involves structure disruption, defects formation, and subsequent recrystallization. Regarding twinning through swap motion, nanocrystals maintain a relatively intact crystal structure, while crystal defects form and propagate during twin nucleation. For the transformation twinning evolving from a bi-crystal twin to fivefold twins (or the reverse processes in detwinning), twinning is accompanied by the decomposition of the twin boundaries, interface migration, and strain modulations. Our results provide new mechanistic understandings of transformation twinning in nanocrystals.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"60 ","pages":"Article 102547"},"PeriodicalIF":13.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energy-based surgery generated carbonized particles promote the development of ovarian cancer 基于能量的手术产生的碳化粒子会促进卵巢癌的发展

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-15 DOI: 10.1016/j.nantod.2024.102555

Yan Chen , Jian Liu , Binhan Wang , Xiao Liang , Yanfei Yang , Xia Zhao , Min Luo , Xiawei Wei

{"title":"Energy-based surgery generated carbonized particles promote the development of ovarian cancer","authors":"Yan Chen , Jian Liu , Binhan Wang , Xiao Liang , Yanfei Yang , Xia Zhao , Min Luo , Xiawei Wei","doi":"10.1016/j.nantod.2024.102555","DOIUrl":"10.1016/j.nantod.2024.102555","url":null,"abstract":"<div><div>Cancer patients face a high risk of tumor recurrence and metastasis after surgery. Surgical stress has been reported to be an important trigger for cancer recurrence and metastasis. Energy-based surgical devices have become the most commonly used surgical tool in recent years. However, there is a lack of studies investigating whether using energy-based surgical devices promotes the development of residual tumors. This study aimed to examine the impact of energy-based surgery on tumor growth in comparison to conventional surgery. Results indicated that energy-based surgery is more likely to promote tumor growth than conventional surgery. Further investigation revealed that the carbonized particles produced by energy-based surgical devices during tissue combustion are robust inducers, strongly inducing the polarization of M2-like macrophages in vivo and in vitro. Additionally, carbonized particles induced an immunosuppressive tumor microenvironment in vivo, promoting tumor growth similarly to energy-based surgery. These findings suggested that the production of carbonized particles during energy-based surgery contributed to the development of residual tumor cells. Therefore, it is advisable to implement measures to either eliminate or prevent the production of carbonized particles during energy-based surgery procedures.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"60 ","pages":"Article 102555"},"PeriodicalIF":13.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipose tissue targeted sequential delivery system regulating glycolipid metabolism for systemic obesity and its comorbidities 调节糖脂代谢的脂肪组织定向序贯给药系统，用于治疗全身性肥胖症及其合并症

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-14 DOI: 10.1016/j.nantod.2024.102553

Yingxian Chen , Xinmiao Lan , Junhua Han , Xin Xiang , Qingmeng Li , Xiaolong Xu , Tingting Wang , Siying Huang , Jianzhong Shen , Xiaowei Ma

{"title":"Adipose tissue targeted sequential delivery system regulating glycolipid metabolism for systemic obesity and its comorbidities","authors":"Yingxian Chen , Xinmiao Lan , Junhua Han , Xin Xiang , Qingmeng Li , Xiaolong Xu , Tingting Wang , Siying Huang , Jianzhong Shen , Xiaowei Ma","doi":"10.1016/j.nantod.2024.102553","DOIUrl":"10.1016/j.nantod.2024.102553","url":null,"abstract":"<div><div>Obesity has emerged as a chronic, relapsing, progressive disease globally. Available methods including pharmacotherapy, surgery, and limotherapy, may lead to toxicities and gastrointestinal disturbances due to their lack of adipose tissue targetability. Increasing energy expenditure and reducing gluconeogenesis through browning of white adipose tissue (WAT) is a therapeutic target for obesity and its comorbidities. Here, we constructed a biomimetic discoidal recombinant high-density lipoprotein (rHDL) with high specificity for scavenger receptor class B type I (SR-BI). rHDL enables targeted delivery of combination drugs (RM) containing rosiglitazone (Rosi) and metformin (Met) to WAT, liver, and intestine, that express elevated levels of SR-BI, resulting in promoted browning of WAT, enhanced mitochondrial biogenesis, and adipocyte thermogenesis increase. For oral delivery, rHDL@RM was loaded in pH-senstive sodium alginate chitosan complex microspheres (MS), enabling stepwise release in the gastrointestinal tract, with mucosal penetration capability that facilitating longlasting lipid-lowering effect. Diet-induced obese (DIO) mice treated with rHDL@RM/MS showed 44.6 % reduction in body weight, with decreased serum glucose and lipid levels. Obesity comorbidities, including NAFLD, gut microbiome disorders, systemic lipid metabolism abnormalities, and chronic inflammation, were all effectively suppressed. Our designed rHDL@RM/MS oral-nanoplatform represents a valuable therapeutic strategy for painless treatment of systemic obesity and related comorbidities.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102553"},"PeriodicalIF":13.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142656902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD33 targeted EzH1 regulated nanotherapy epigenetically inhibits fusion oncoprotein (AML1-ETO) rearranged acute myeloid leukemia in both in vitro and in vivo Patient Derived Xenograft models 在体外和体内患者衍生异种移植模型中，CD33 靶向 EzH1 调控纳米疗法从表观遗传学角度抑制融合癌蛋白（AML1-ETO）重排的急性髓性白血病

IF 13.2 1区材料科学

Nano Today Pub Date : 2024-11-14 DOI: 10.1016/j.nantod.2024.102542

Avinash Chandra Kushwaha , Boddu Mrunalini , Devangi Ghosh , Pankaj Malhotra , Surajit Karmakar , Subhasree Roy Choudhury

{"title":"CD33 targeted EzH1 regulated nanotherapy epigenetically inhibits fusion oncoprotein (AML1-ETO) rearranged acute myeloid leukemia in both in vitro and in vivo Patient Derived Xenograft models","authors":"Avinash Chandra Kushwaha , Boddu Mrunalini , Devangi Ghosh , Pankaj Malhotra , Surajit Karmakar , Subhasree Roy Choudhury","doi":"10.1016/j.nantod.2024.102542","DOIUrl":"10.1016/j.nantod.2024.102542","url":null,"abstract":"<div><div>Acute myeloid leukemia (AML) is one of the most heterogeneous myeloid malignancies wherein the genetic and epigenetic markers contribute to AML pathogenesis. Genetic regulators such as fusion oncogene, AML1-ETO, controls AML pathogenesis and contribute to ∼20 % AML cases. The epigenetic factors such as histone methyltransferase, EzH1, is highly overexpressed in AML and regulate AML proliferation. The EzH1 inhibition overturns disease pathology but available therapeutics exhibit off-target toxicity and frequent relapses which lack AML targeting ability. Here, we have prepared CD33-targeted S30 aptamer-functionalized human serum albumin nanoparticles for EzH1 siRNA delivery for the first time as anti-AML therapeutics in vitro, in vivo nude mice and patient-derived xenografts models. The S30 aptamer functionalization enhanced the transfection efficiency and cytotoxicity through apoptosis and increased the reduction of c-Kit<sup>+</sup> leukemia cells along with upregulation of myeloid differentiation markers, CD11b and Gr-1, in nude mice AML xenografts. The nanoparticles exhibited the similar efficacy with improved survival outcome in patient-derived xenografts. Furthermore, we for the first time showed that transcription factor, C-Myb, directly regulates EzH1 through promoter binding which regulates the functional characteristics of <em>in vivo</em> AML. The present nanotherapy abrogates C-Myb–EzH1 crosstalk mediated AML pathogenesis and holds future translation potential as novel anti-AML therapeutics.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102542"},"PeriodicalIF":13.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0