Nano Today最新文献_第2页

Outside Back Cover - Graphical abstract TOC/TOC in double column/Cover image legend if applicable, Bar code, Abstracting and Indexing information 封底外-图形摘要TOC/双栏TOC/封面图例（如适用），条形码，摘要和索引信息

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-06-01 Epub Date: 2026-06-05 DOI: 10.1016/S1748-0132(26)00124-6

引用次数: 0

Inside Back Cover - Graphical abstract TOC/TOC in double column continued from OBC if required, otherwise blank page 封底内-图解摘要TOC/TOC双栏，如果需要，从OBC继续，否则空白页

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-06-01 Epub Date: 2026-06-05 DOI: 10.1016/S1748-0132(26)00123-4

引用次数: 0

Near-infrared light-controlled multimodal mitochondria therapy overcomes triple‑negative breast cancer 近红外光控制的多模态线粒体疗法克服三阴性乳腺癌

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-06-01 Epub Date: 2026-05-26 DOI: 10.1016/j.nantod.2026.103087

Yang Li , Tao Jia , Jiarui Du , Feng Li , Hans Ågren , Guanying Chen

{"title":"Near-infrared light-controlled multimodal mitochondria therapy overcomes triple‑negative breast cancer","authors":"Yang Li , Tao Jia , Jiarui Du , Feng Li , Hans Ågren , Guanying Chen","doi":"10.1016/j.nantod.2026.103087","DOIUrl":"10.1016/j.nantod.2026.103087","url":null,"abstract":"<div><div>Targeting mitochondria offers a powerful strategy against aggressive cancers like triple negative breast cancer (TNBC), yet achieving synergistic, multimodal therapeutic effects remains a formidable challenge. The primary hurdle is the lack of precise spatiotemporal control over these combined modalities, often resulting in systemic toxicity and compromised efficacy. Here, we develop a near-infrared (NIR)-light-gated nanoplatform that places a triple-pronged mitochondrial assault under precise photonic command. Central to our design, NIR-excited upconversion nanoparticles activate an embedded photo-acid generator (o-nitrobenzaldehyde, o-NBA) to create a rapid, localized acidic spike within the tumor microenvironment. This single acid-trigger simultaneously drives the decomposition of iron disulfide, releasing Fe<sup>2 +</sup> for potent chemodynamic therapy and hydrogen disulfide (H<sub>2</sub>S<sub>2</sub>) as an intermediate. The H<sub>2</sub>S<sub>2</sub> then reacts with glutathione (GSH) to generate hydrogen sulfide (H<sub>2</sub>S), which critically sensitizes cancer cells to ferroptosis by depleting GSH and inhibiting catalase (CAT). At the same time, the acidic milieu facilitates the controlled release of Lapatinib (Lp) to induce mitochondrial structural collapse and apoptosis. This orchestrated triple-blow, converging on the mitochondrial matrix, demonstrates exceptional antitumor efficacy in both <em>in vitro</em> and <em>in vivo</em> models, presenting a potent paradigm for stimuli-responsive, precision therapy against TNBC.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"69 ","pages":"Article 103087"},"PeriodicalIF":10.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148183771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “A metalloprotein nanoparticle scaffold co-delivers antigens and adjuvants with metal-enhanced STING activation for vaccination preventing viral infections” [Nano Today 55 (2024) 102156] “金属蛋白纳米颗粒支架共同递送抗原和佐剂与金属增强STING激活疫苗预防病毒感染”的勘误表[Nano Today 55 (2024) 102156]

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-06-01 Epub Date: 2026-06-05 DOI: 10.1016/j.nantod.2026.103072

Jiexin Li , Qian Qiu , He Ren , Jingyu Zhang , Chen Zhang , Gengqi Liu , Boyang Sun , Bin Zheng , Jonathan F. Lovell , Yumiao Zhang

引用次数: 0

Bigel microspheres encapsulating supramolecular bioactives enabled by electrospraying for colon-targeted delivery and ulcerative colitis therapy Bigel微球封装超分子生物活性，通过电喷涂实现结肠靶向递送和溃疡性结肠炎治疗

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-06-01 Epub Date: 2026-05-25 DOI: 10.1016/j.nantod.2026.103079

Zhiwen Gu , Yuting Jiang , Xingyu Xu , Yihao He , Lu Yang , Yi Zhang , Lan Shen , Yongzhuo Huang

引用次数: 0

Corrigendum to “Nanogels confined superactive LOx-CPO for TME-responsive enzyme-gene therapy” [Nano Today 65 (2025), 102821] “纳米凝胶限制超活性LOx-CPO用于tme反应酶基因治疗”的勘误表[Nano Today 65 (2025), 102821]

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-06-01 Epub Date: 2026-04-21 DOI: 10.1016/j.nantod.2026.103059

Xueting Liu , Dingze Zhou , Yuxi Zhang , Zonghui Zhao , Wenhao Zhao , Xia Wang , Qigang Wang

引用次数: 0

Spin-mediated and proton-coupled electron transfer boost NADH oxidase-like activity of dual-atom metallozymes 自旋介导和质子耦合电子转移增强双原子金属酶NADH氧化酶样活性

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-04-01 Epub Date: 2026-02-03 DOI: 10.1016/j.nantod.2026.102996

Jiarong Li , Yonghui Li , Zhen Wan , Hongyang Li , Haitao Dai , Changlong Liu , Xiaoyu Mu , Xiao-Dong Zhang

{"title":"Spin-mediated and proton-coupled electron transfer boost NADH oxidase-like activity of dual-atom metallozymes","authors":"Jiarong Li , Yonghui Li , Zhen Wan , Hongyang Li , Haitao Dai , Changlong Liu , Xiaoyu Mu , Xiao-Dong Zhang","doi":"10.1016/j.nantod.2026.102996","DOIUrl":"10.1016/j.nantod.2026.102996","url":null,"abstract":"<div><div>Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) as a pivotal coenzyme plays a central role in the pathogenesis of various inflammatory diseases. However, both natural and artificial NADH oxidase (NOX) systems exhibit limited efficacy in NAD<sup>+</sup> regeneration. Here, we developed a RuCo heterogeneous dual atom metallozymes (DAMs) with over-natural NOX activity through spin-mediated and proton-coupled electron transfer (PCET). Under simulated inflammatory microenvironment, DAMs exhibited a catalytic efficiency (<em>K</em><sub><em>cat</em></sub><em>/K</em><sub><em>m</em></sub>) of 0.99 μM<sup>−1</sup>min<sup>−1</sup>, surpassing reported artificial enzymes by ∼9–99 times. Additionally, its quantitative NOX activity reached 2139 U/mg, about 6–18 times that of common microbial enzymes. The experimental and computational studies revealed that Co not only modulated the spin state of Ru from low-spin to middle-spin, but also its electrophilic microenvironment facilitated oxygen adsorption to further modulate electronic behavior of Ru with high-spin. Thus, Ru-Co-O as high active sites preferred to trap electron and proton from NADH and acidic conditions via a PECT mechanism. In a skin injury model, DAMs alleviated inflammation and promoted skin regeneration by restoring the NAD<sup>+</sup>/NADH ratio, enhancing energy metabolism, and driving macrophage anti-inflammatory polarization. Notably, no relapse was observed within 20 days post-treatment, highlighting the long-lasting therapeutic impact of DAMs.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"68 ","pages":"Article 102996"},"PeriodicalIF":10.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorinated amphipathic cationic peptides for intracellular protein delivery and cancer immunotherapy 用于细胞内蛋白传递和癌症免疫治疗的氟化两性阳离子肽

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-04-01 Epub Date: 2026-01-24 DOI: 10.1016/j.nantod.2026.102979

Wenhua Cheng , Yan Lou , Yiyun Cheng , Xin Gao , Quan Huang

{"title":"Fluorinated amphipathic cationic peptides for intracellular protein delivery and cancer immunotherapy","authors":"Wenhua Cheng , Yan Lou , Yiyun Cheng , Xin Gao , Quan Huang","doi":"10.1016/j.nantod.2026.102979","DOIUrl":"10.1016/j.nantod.2026.102979","url":null,"abstract":"<div><div>Cell penetrating peptides are widely developed as carriers to transport proteins inside cells, but there remain some drawbacks such as limited protein loading capacity and nanoparticle stability, endosomal escape and intracellular delivery efficacy. Herein, we design a family of fluorinated amphipathic cationic peptides (FACPs) to address these issues. A library of amphipathic cationic hexapeptides is conjugated with a fluorous tag at the <em>C</em>-terminus via a dynamic hydrazone bond. Among the investigated materials, FACP2 (peptide sequence: RRRWWW) demonstrates the optimal performance in protein binding, cellular uptake, endosomal escape, and thus intracellular delivery efficacy. It efficiently delivers ovalbumin into bone marrow derived dendritic cells and stimulates their maturation, enhancing the antigen cross-presentation both <em>in vitro</em> and <em>in vivo</em>. As a result, the FACP2/ovalbumin nanovaccine effectively inhibits the tumor growth in mice when combined with anti-PD1 therapy or co-delivered with the STING agonist 2′,3′-cyclic guanosine monophosphate. This study provides a highly efficient peptide nanocarrier for cytosolic protein delivery and cancer immunotherapy through antigen and adjuvant co-delivery.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"68 ","pages":"Article 102979"},"PeriodicalIF":10.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted isolation of astrocyte-derived extracellular vesicles using peptide-imprinted nanocomposites for neurological diagnostics 利用肽印迹纳米复合材料靶向分离星形胶质细胞来源的细胞外囊泡用于神经诊断

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-04-01 Epub Date: 2026-02-06 DOI: 10.1016/j.nantod.2026.103001

Hyo Joo Lee , Yeonjeong Roh , Thuy Nguyen Thi Dao , Jin Hee Kim , Wangyong Shin , Dayoung Seo , Bonhan Koo , Eun-Jae Lee , Yong Shin

{"title":"Targeted isolation of astrocyte-derived extracellular vesicles using peptide-imprinted nanocomposites for neurological diagnostics","authors":"Hyo Joo Lee , Yeonjeong Roh , Thuy Nguyen Thi Dao , Jin Hee Kim , Wangyong Shin , Dayoung Seo , Bonhan Koo , Eun-Jae Lee , Yong Shin","doi":"10.1016/j.nantod.2026.103001","DOIUrl":"10.1016/j.nantod.2026.103001","url":null,"abstract":"<div><div>Neurological disorders require early detection, yet traditional diagnostic methods lack specificity and sensitivity. Blood-derived extracellular vesicles (EVs) provide a promising, non-invasive alternative for biomarker discovery in neurological disorders, despite challenges in cell-specific isolating them from brain related EVs due to their complexity and scarcity. However, the heterogeneity and low yield of EVs, common EVs isolation methods remain challenges, then the development of more efficient and accurate isolation approach. This study presents Engineering Peptide-Imprinted Nanocomposites (EPIN) as an innovative platform for isolating cell-specific EVs from biological matrices, overcoming the limitations of conventional methods. Utilizing magnetic nanoparticles, EPIN is developed with peptide template that bind specifically to EVs surface proteins, enhancing the capture efficiency. Targeting proteins CD63, CD9, and CD81, EPIN shows high specificity in isolating EVs, compared with current existing assays. In particular, EPIN-glutamate aspartate transporter (GLAST) effectively isolates astrocyte-derived EVs in blood, indicating significant promise for monitoring neuromyelitis optica spectrum disorder (NMOSD), where astrocytopathy is a key feature. The utility of EPIN-GLAST is demonstrated using 147 blood samples by integrating brain-derived proteins and miRNAs, establishing a platform for disease-specific monitoring. This approach extends beyond detecting astrocytic damage in NMOSD, representing a significant advancement in EV-based diagnostics. These findings underscore the capability of EPIN-GLAST in elucidating disease dynamics and emphasize the value of targeted EVs analysis in neurological disorder research, enabling novel biomarker discovery.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"68 ","pages":"Article 103001"},"PeriodicalIF":10.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carrier-free self-assembly of choline chloride-ammonium glycyrrhizinate hydrogel for myocardial infarction microenvironment regulation 无载体自组装氯化胆碱-甘草酸铵水凝胶对心肌梗死微环境的调节

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1016/j.nantod.2026.103014

Yi Hu , Wenhui Yang , Jiamian Zhan , Yue Ma , Pengqi Wang , Chunyi Pu , Linfang Zhong , Xiaozhong Qiu , Honghao Hou

{"title":"Carrier-free self-assembly of choline chloride-ammonium glycyrrhizinate hydrogel for myocardial infarction microenvironment regulation","authors":"Yi Hu , Wenhui Yang , Jiamian Zhan , Yue Ma , Pengqi Wang , Chunyi Pu , Linfang Zhong , Xiaozhong Qiu , Honghao Hou","doi":"10.1016/j.nantod.2026.103014","DOIUrl":"10.1016/j.nantod.2026.103014","url":null,"abstract":"<div><div>Myocardial infarction (MI)-induced persistent disruption of the myocardial microenvironment is one of the key mechanisms driving the onset of heart failure. Precise modulation of this pathological microenvironment <em>in vitro</em> has emerged as an important strategy to improve MI prognosis and delay heart failure progression. In this study, we constructed carrier‑free choline chloride (ChCl)–ammonium glycyrrhizinate (AG) self‑assembled hydrogels. Initially, network pharmacology combined with big data analysis was employed to predict the synergistic therapeutic effects of ChCl and AG. Subsequently, multi‑scale characterisation techniques, including FT-IR, SEM, and rheology, were used to analyse the structural features of the gel system. Molecular dynamics and quantum chemical calculations indicated that hydrophobic, electrostatic, and hydrogen‑bond interactions jointly drive self‑assembly, and Cryo‑SEM revealed for the first time a near‑native interpenetrating sheet‑like fibrous network. In an <em>in vitro</em> MI model, the ChCl-AG self-assembled hydrogel reduced oxidative stress, shifted macrophages from pro‑inflammatory M1 to reparative M2, increased endogenous antioxidant enzyme activity, and downregulated pro‑inflammatory cytokines, thereby preserving microenvironmental homeostasis and providing cardioprotection. Transcriptomics indicated positive regulation of pathways linked to cardiac structure, contractility, energy metabolism, and cardiovascular disease. <em>In vivo</em> MI models, the ChCl-AG self-assembled hydrogel markedly promoted myocardial repair and functional recovery while exhibiting good biocompatibility and sustained release. Overall, the carrier‑free ChCl-AG self-assembled hydrogel provides a precise strategy to modulate post‑MI inflammatory and oxidative imbalances, promote myocardial repair, and holds broader biomedical potential.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"68 ","pages":"Article 103014"},"PeriodicalIF":10.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0