Nano Today最新文献_第10页

Engineered bacteria with inserted CAR cell membranes for enhanced tumor targeting and biotherapy 植入CAR细胞膜的工程细菌用于增强肿瘤靶向和生物治疗

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-12 DOI: 10.1016/j.nantod.2025.102799

Si-Min Zeng, Ke-Wei Chen, Ting Pan, Yun-Xia Sun, Jun Feng, Xian-Zheng Zhang

{"title":"Engineered bacteria with inserted CAR cell membranes for enhanced tumor targeting and biotherapy","authors":"Si-Min Zeng, Ke-Wei Chen, Ting Pan, Yun-Xia Sun, Jun Feng, Xian-Zheng Zhang","doi":"10.1016/j.nantod.2025.102799","DOIUrl":"10.1016/j.nantod.2025.102799","url":null,"abstract":"<div><div>Although bacteria have been widely applied in treating various tumors, their inadequate tumor-specific targeting and in vivo controllability often result in suboptimal therapeutic outcomes and inevitable side effects post-administration. Here, we develop an acid-responsive engineered bacteria system (CARM-Bac<sup>ClyA</sup>) with inserted chimeric antigen receptor (CAR) cell membranes (M) for enhanced tumor targeting and biotherapy. Specifically, we genetically engineer attenuated <em>Escherichia coli</em> to construct acid-responsive therapeutic bacteria (Bac<sup>ClyA</sup>) that express cytotoxic cytolysin A (ClyA) proteins. Simultaneously, we genetically engineer cells to construct cells that express CARs specifically targeting tumor antigens. Subsequently, CARM fragments are inserted into Bac<sup>ClyA</sup> during plasmolysis and deplasmolysis (P/deP) to obtain CARM-Bac<sup>ClyA</sup>. As a proof-of-concept study, in the mouse solid B-cell lymphoma model, the enrichment of CARM-Bac<sup>ClyA</sup> at tumor sites is significantly increased to 2.5-fold that of naked Bac<sup>ClyA</sup> after systemic administration. Furthermore, the acidic pH triggers Bac<sup>ClyA</sup> to express ClyA proteins, leading to perforation-induced tumor cell death, thereby inhibiting tumor growth. This work introduces a strategy for manipulating engineered bacterial behaviors, and proves the potential of CARM-inserted engineered bacteria for enhanced tumor targeting and biotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102799"},"PeriodicalIF":13.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light tunes the social behavior of honeybee via gut microbiota with MXene 光通过肠道微生物群与MXene调节蜜蜂的社会行为

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-12 DOI: 10.1016/j.nantod.2025.102775

Yueyi Wang , Bin Wang , Xiaohuan Mu , Yue Qi , Yujie Meng , Xiaofei Wang , Hao Zheng , Yuan Lu

{"title":"Light tunes the social behavior of honeybee via gut microbiota with MXene","authors":"Yueyi Wang , Bin Wang , Xiaohuan Mu , Yue Qi , Yujie Meng , Xiaofei Wang , Hao Zheng , Yuan Lu","doi":"10.1016/j.nantod.2025.102775","DOIUrl":"10.1016/j.nantod.2025.102775","url":null,"abstract":"<div><div>Honeybees are essential pollinators with complex social behaviors and serve as a model for neurobiological research. It is noticed that regulating gut microbiota is a novel method to modulate host behavior through the gut-brain axis. Among various modulation strategies, light offers advanced advantages due to its precise temporal and spatial control. This study leverages the photosensitive properties of nanomaterial MXene to modulate honeybee gut microbiota via light control, impacting neural functions and behavior. Light exposure increases <em>Snodgrassella</em> abundance, gut immune gene expression, and inhibitory neurotransmitters like histamine. Subsequently, the expression of brain genes related to olfactory function is reduced, decreasing social interactions. MXene treatment similarly boosts <em>Snodgrassella</em> and gut immune genes, inhibiting brain genes related to neurite outgrowth and reducing locomotion and social behavior. However, combined light and MXene treatment increases levels of the excitatory neurotransmitter serotonin and enhances social interactions. This study offers insights into gut-brain axis modulation by physics approach and its effects on honeybee health.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102775"},"PeriodicalIF":13.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inside Back Cover - Graphical abstract TOC/TOC in double column continued from OBC if required, otherwise blank page 封底内-图解摘要TOC/TOC双栏，如果需要，从OBC继续，否则空白页

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-10 DOI: 10.1016/S1748-0132(25)00168-9

引用次数: 0

Outside Back Cover - Graphical abstract TOC/TOC in double column/Cover image legend if applicable, Bar code, Abstracting and Indexing information 封底外-图形摘要TOC/双栏TOC/封面图例（如适用），条形码，摘要和索引信息

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-10 DOI: 10.1016/S1748-0132(25)00169-0

引用次数: 0

Understanding the zeta potential of nanomaterials through predictive nanoinformatics 通过预测纳米信息学了解纳米材料的zeta电位

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-08 DOI: 10.1016/j.nantod.2025.102783

Kamila Jarzynska , Krzesimir Ciura , Xuejiao J. Gao , Alicja Mikolajczyk , Xingfa Gao , Tomasz Puzyn

{"title":"Understanding the zeta potential of nanomaterials through predictive nanoinformatics","authors":"Kamila Jarzynska , Krzesimir Ciura , Xuejiao J. Gao , Alicja Mikolajczyk , Xingfa Gao , Tomasz Puzyn","doi":"10.1016/j.nantod.2025.102783","DOIUrl":"10.1016/j.nantod.2025.102783","url":null,"abstract":"<div><div>Nanomaterials are employed extensively in materials engineering and nanomedicine due to their unique properties. Therefore, understanding how they interact in the environment is imperative to ensure the successful development of complex and safe nanomaterials. The zeta potential is a principal determinant of the behavior of nanomaterials, including surface charge characteristics and stability. This article presents the first comprehensive review of recent advances in the computational study of the relationships between nanomaterial structure and its zeta potential. The implementation of data-driven methods for this purpose is analyzed, particularly the machine learning-based modeling of nano-quantitative structure-property relationships. Moreover, this review examines the application of physics-based methods, specifically quantum mechanics, including density functional theory calculations, molecular dynamics, and Monte Carlo simulations, to predict and understand the factors influencing the zeta potential of nanomaterials in environments, including medium-nanosurface interactions, at the molecular level. The importance of theoretically characterizing the molecular structure by utilizing complex nanodescriptors and their mechanistic interpretation have also been discussed. In summary, this article describes the application of nanoinformatics in predicting the zeta potential of NMs, from its evolving landscape to its challenges and future directions.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102783"},"PeriodicalIF":13.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered organoid precursor with micro-nano materials for boosting nucleus pulposus reconstruction after discectomy 微纳材料工程类器官前体促进椎间盘切除术后髓核重建

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-08 DOI: 10.1016/j.nantod.2025.102786

Liqun Chen , Zhen Zhang , Tongxing Zhang , Mingyang Gao , Lilong Du , Dong Ming , Baoshan Xu

{"title":"Engineered organoid precursor with micro-nano materials for boosting nucleus pulposus reconstruction after discectomy","authors":"Liqun Chen , Zhen Zhang , Tongxing Zhang , Mingyang Gao , Lilong Du , Dong Ming , Baoshan Xu","doi":"10.1016/j.nantod.2025.102786","DOIUrl":"10.1016/j.nantod.2025.102786","url":null,"abstract":"<div><div>Nucleus pulposus (NP) discectomy is a clinical procedure used to treat late-stage intervertebral disc degeneration. Although it can relieve pain symptoms, self-repair and regeneration of the NP tissues cannot be realized due to low regenerative capacity and inhibitory microenvironment. Here, we develop an engineered NP organoid precursor (OP) to reconstruct severely defective NP tissues, which is self-assembled and induced from bone marrow mesenchymal stem cells with functional micro-nanomaterials. Decellularized extracellular matrix microparticles from NP provide biomimetic matrix structure and enriched active ingredients to enhance the survival and chondrogenic differentiation of bone marrow mesenchymal stem cells. Commodified with transforming growth factor -β3, titanium carbide nanozyme with high reactive oxygen species scavenging capacity, exhibiting dual pro-differentiation and anti-inflammatory functions. The total integration of these functional components into 3D cell spheroid induces the formation of OP resembling certain structures and functions of the natural NP, as well as microenvironmental regulatory capabilities. In the rat nucleotomy model, the injection of pre-differentiated NP-OP significantly alleviates oxidative stress and inflammation, maintains disc height and water content, and accelerates new extracellular matrix deposition, thus promoting effective NP reconstruction. Overall, this engineered NP-OP provides a promising therapeutic approach for severe intervertebral disc degeneration.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102786"},"PeriodicalIF":13.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-situ synthesis of flexible aramid nanofiber@CsPbBr3 coaxial fiber-based paper for effective X-ray shielding 原位合成柔性芳纶nanofiber@CsPbBr3同轴纤维基纸的有效x射线屏蔽

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-07 DOI: 10.1016/j.nantod.2025.102788

Zizhan Guo , Zhaoqing Lu , Jingru Zhang , Ming Jiang , Guoqiang Peng , Li Hua , Jiayue Dong , Fengfeng Jia , Zhigang Xia , Zhiwen Jin

{"title":"In-situ synthesis of flexible aramid nanofiber@CsPbBr3 coaxial fiber-based paper for effective X-ray shielding","authors":"Zizhan Guo , Zhaoqing Lu , Jingru Zhang , Ming Jiang , Guoqiang Peng , Li Hua , Jiayue Dong , Fengfeng Jia , Zhigang Xia , Zhiwen Jin","doi":"10.1016/j.nantod.2025.102788","DOIUrl":"10.1016/j.nantod.2025.102788","url":null,"abstract":"<div><div>Flexible X-ray shielding materials feature better adaptability and dexterity than traditional rigid shielding materials. The effective enhancement of the comprehensive properties of flexible X-ray shielding materials lies in boosting the loading of X-ray absorbing filler while ensuring the retention of their favorable mechanical strength. Here, we designed a Chinese stone arch bridge-like coaxial structure to increase the loading of X-ray absorbing filler CsPbBr<sub>3</sub> in aramid nanofiber (ANF) based composites. The robust and flexible ANF@CsPbBr<sub>3</sub> coaxial fibers were fabricated via coaxial wet-spinning method. The CsPbBr<sub>3</sub> core were rapid in situ crystallized within ANF shell, which achieves the thrilling load capacity for CsPbBr<sub>3</sub> in the material and provides protection against CsPbBr<sub>3</sub> leakage and intrusion of outside moisture, ensuring outstanding X-ray shielding performances. The Chinese stone arch bridge-like structure obtained during spinning effectively prevented collapse of the coaxial fiber shell. Moreover, the ANF@CsPbBr<sub>3</sub> coaxial fibers have excellent flexibility to fabricate an X-ray shielding paper through conventional papermaking process. It also had robust tensile stress (11.8 MPa), lightweight (1.01 g/cm<sup>3</sup>), excellent X-ray attenuation efficiency (exceed ∼93 % in the 20–70 kV range), and weakened secondary radiation. These findings indicate that the ANF@CsPbBr<sub>3</sub> coaxial fiber have a promising potential for developing X-ray shielding materials.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102788"},"PeriodicalIF":13.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ microneedle-based system with “Tripartite Delivery” characteristics for local antisense oligonucleotide therapy in acute bacterial infections 具有“三方递送”特性的原位微针系统用于急性细菌感染的局部反义寡核苷酸治疗

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-07 DOI: 10.1016/j.nantod.2025.102780

Xiaolu Han , Zengming Wang , Xiang Gao , Xiaoxuan Hong , Jingyou Bi , Jintao Lin , Xiwei Wang , Hui Zhang , Nan Liu , Xianfu Li , Yi Cheng , Haihua Xiao , Liang Xu , Aiping Zheng

{"title":"In situ microneedle-based system with “Tripartite Delivery” characteristics for local antisense oligonucleotide therapy in acute bacterial infections","authors":"Xiaolu Han , Zengming Wang , Xiang Gao , Xiaoxuan Hong , Jingyou Bi , Jintao Lin , Xiwei Wang , Hui Zhang , Nan Liu , Xianfu Li , Yi Cheng , Haihua Xiao , Liang Xu , Aiping Zheng","doi":"10.1016/j.nantod.2025.102780","DOIUrl":"10.1016/j.nantod.2025.102780","url":null,"abstract":"<div><div>The management of the acute bacterial infections in the traumatic skin remains a significant challenge in clinical. The application of antibiotics on wounds is typically avoided due to antimicrobial resistance risks. Antisense therapeutics, like antisense oligonucleotides (ASOs), present a selective, low-resistance alternative, but effective bacterial uptake is still a major obstacle. In this work, we developed a novel microneedle-based delivery system (MNDS) distinguished by its distinctive multifunctional hydrogels and a “Tripartite Delivery” mechanism. The MNDS was designed with a bionic mushroom-shaped multilayered structure. Upon application, the MNDS enabled an initial rapid release and sustained release of the encapsulated nanocomplexes (ASO@GP-SiNPs). The needle body layer hydrogels can respond to hyaluronidase and continuously release hyaluronic acid and <em>ε</em>-polylysine for several days. These ASO@GP-SiNPs were effectively uptaken by <em>E. coli</em> (46.4 %) and <em>S. aureus</em> (37.1 %), subsequently releasing ASOs that target the <em>acpP</em> and <em>ftsZ</em> genes to effectively eliminate bacteria. The system exhibits significant antibacterial activity and effectively inhibits biofilm formation, while also inducing the polarization of macrophages toward an M2-like phenotype. Additionally, the system demonstrates excellent biocompatibility. In conclusion, this paper presents a novel strategy for addressing the challenges of acute bacterial infections in traumatic skin by utilizing the advanced functionalities of MNDS.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102780"},"PeriodicalIF":13.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface micro/nano-biomimetic structures regulate cellular energy metabolism to induce tissue regeneration 表面微纳米仿生结构调节细胞能量代谢，诱导组织再生

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-06 DOI: 10.1016/j.nantod.2025.102789

Yuxiang Zhang , Jingming Li , Linnan Wang , Jiajun Liu , Kai Zhang , Xingdong Zhang , Bo Yuan , Xiangdong Zhu

{"title":"Surface micro/nano-biomimetic structures regulate cellular energy metabolism to induce tissue regeneration","authors":"Yuxiang Zhang , Jingming Li , Linnan Wang , Jiajun Liu , Kai Zhang , Xingdong Zhang , Bo Yuan , Xiangdong Zhu","doi":"10.1016/j.nantod.2025.102789","DOIUrl":"10.1016/j.nantod.2025.102789","url":null,"abstract":"<div><div>Energy metabolism serves as a critical means through which the body modulates cellular differentiation and tissue regeneration processes, while the strategy of using materials to reprogram it for tissue regeneration remains a significant challenge. Here, we utilized plasma-induced technology to develop a hierarchical micro-nano-porous structure with bone-like heterogeneous properties on the surface of bioinert material. The in vitro studies indicated that the biomimetic morphology can influence the mitochondrion around the microtubules in BMSCs via stretching its cytoskeleton, which further triggers the intracellular oxidative phosphorylation pathway, thereby elevating ATP production and inducing cell osteogenic differentiation. Following implantation in rat femoral condyles and goat intervertebral defects, the implants rapidly promote interfacial osseointegration and induce bone regeneration. This study not only presents a novel strategy to address the clinical issue of biomaterials implantation failure but also provides valuable insights into the influence of material morphology on cellular metabolic energy and its underlying mechanisms.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102789"},"PeriodicalIF":13.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoconfined heterojunctions with enhanced piezoelectricity for amplifying reactive oxygen species storms-triggered tumor ferroptosis-like/apoptosis 增强压电的纳米限制异质结放大活性氧风暴引发的肿瘤铁致凋亡样/凋亡

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-05 DOI: 10.1016/j.nantod.2025.102785

Jiarui Wang , Gao He , Lile Dong , Xujian Yang , Hongpeng You , Shuyan Song

{"title":"Nanoconfined heterojunctions with enhanced piezoelectricity for amplifying reactive oxygen species storms-triggered tumor ferroptosis-like/apoptosis","authors":"Jiarui Wang , Gao He , Lile Dong , Xujian Yang , Hongpeng You , Shuyan Song","doi":"10.1016/j.nantod.2025.102785","DOIUrl":"10.1016/j.nantod.2025.102785","url":null,"abstract":"<div><div>Poor separation and rapid recombination of electron-hole pairs hinder the reactive oxygen species (ROS) generation efficiency of sonosensitizers and hampers the efficacy of tumor therapy. To overcome these obstacles, the nanoconfinement-enhanced strategy was proposed to construct polyvinylpyrrolidone-modified ZnO<sub>2</sub> nanomedicines loaded with IrO<sub>2</sub> (IZH) for piezoelectric therapy. Nanoconfinement activates IrO<sub>2</sub> nanoclusters for carrier separation, and the ultrasound current density of IZH (29.4 nA cm<sup>−2</sup>) is 2.9 times that of ZnO<sub>2</sub> (10.3 nA cm<sup>−2</sup>) under the ultrasound irradiation. In addition, the internal electric field between IrO<sub>2</sub> and ZnO<sub>2</sub> accelerates electron directed migration under ultrasound. Interestingly, this strategy augmented ROS generation induces ferroptosis-like/apoptosis with the tumor inhibition rate of 90 %. This study provides an promising nanoplatform to trigger efficient carrier separation for enhancing ROS generation through an iridium-based nanoconfinement piezoelectric sonosensitizer on ferroptosis-like and apoptosis, providing new guidance for exploring candidates for piezoelectric therapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102785"},"PeriodicalIF":13.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0