Nano Today最新文献_第10页

Seeing the invisible: Nanoscopy with acoustic AFM 看不见的：声学原子力显微镜的纳米显微镜

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-09-10 DOI: 10.1016/j.nantod.2025.102895

Ye Tian , Biao-Feng Zeng , Jian Chen , Longhua Tang

{"title":"Seeing the invisible: Nanoscopy with acoustic AFM","authors":"Ye Tian , Biao-Feng Zeng , Jian Chen , Longhua Tang","doi":"10.1016/j.nantod.2025.102895","DOIUrl":"10.1016/j.nantod.2025.102895","url":null,"abstract":"<div><div>Acoustic atomic force microscopy (AFM) addresses the limitations of traditional imaging for seeing the invisible subsurface nanofeatures with the advantages of both the noninvasive penetration of ultrasound and the nanoscale resolution of AFM. This review emphasizes key achievements and recent advancements of the acoustic AFM, focusing on improvements in multi-modal excitation, multi-scheme operation, multi-component applications, and multi-parameter imaging. Theoretical algorithms and limitations including amplitude attenuation, frequency shift, phase transition, and energy consumption are analyzed, and discrepancies among models, simulations, and experiments are discussed. The review also examines the applications of acoustic AFM in advanced semiconductor nanodevices, the characterization of functional material properties, and the monitoring of living systems. Results emphasize the potential of integrating ultrasonic AFM with quantum sensing and artificial intelligence to develop refined nanoscale fluctuation models, innovate multi-modal probes, and create high-throughput data processing algorithms. These advancements aim to achieve wide-field, high-throughput, ultra-high spatial-temporal resolution, and real-time dynamic nondestructive monitoring of samples with complex structures and environments, paving the way for the next generation of ultrasonic AFM.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102895"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomineralization-inspired nanosheet transformation potentiates cancer therapy through precise embolization and antitumor immunity restoration 生物矿化激发的纳米片转化通过精确栓塞和抗肿瘤免疫恢复来增强癌症治疗

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-12-31 DOI: 10.1016/j.nantod.2025.102971

Kangli Guo , Ling Liang , Ying Liu , Xiaoyi Zhao , Bo Zhi Chen , Dandan Sui , Xin Dong Guo , Fu-Jian Xu , Nana Zhao

{"title":"Biomineralization-inspired nanosheet transformation potentiates cancer therapy through precise embolization and antitumor immunity restoration","authors":"Kangli Guo , Ling Liang , Ying Liu , Xiaoyi Zhao , Bo Zhi Chen , Dandan Sui , Xin Dong Guo , Fu-Jian Xu , Nana Zhao","doi":"10.1016/j.nantod.2025.102971","DOIUrl":"10.1016/j.nantod.2025.102971","url":null,"abstract":"<div><div>Tumor vasculature targeting therapy represents a promising approach to inhibit tumor growth by disrupting the supply of nutrients and oxygen. However, achieving tumor-specific embolization remains a great challenge while the severe disruption of the vascular supply is supposed to aggravate tumor immunosuppression. Inspired by natural biomineralization process of magnesium phosphate, we developed a novel approach combining Mg(OH)<sub>2</sub> nanosheets with microneedles (MNs) for precise tumor embolization and enhanced immunotherapy. Triggered by elevated concentrations of hydrogen ions and phosphate in the tumor microenvironment (TME), Mg(OH)<sub>2</sub> nanosheets undergo a transformation into biomineralized magnesium phosphate precipitates for tumor-specific embolization. Furthermore, these nanosheets exhibit intrinsic immunomodulatory properties, capable of reversing immunosuppression by neutralizing the acidic TME. Additionally, they induce dendritic cell maturation and oxidative stress in tumor cells, triggering immunogenic cell death and eliciting robust antitumor immune responses. To further enhance the efficiency, the MN platform enables co-delivery of the antiangiogenic drug sunitinib with Mg(OH)<sub>2</sub> nanosheets. The satisfactory antitumor effects of the Mg(OH)<sub>2</sub>-MNs platform <em>in vivo</em> were validated in a 4T1 tumor-bearing mice model. Transcriptomics analysis confirmed the activation of strong antitumor immunity and successful immunosuppression reversal. This study proposes a promising biomineralization-inspired strategy to construct immunomodulatory nanomaterials for tumor-specific embolization and enhanced immunotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102971"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manganese in metalloimmunotherapy: From molecular targets to material engineering and translational therapeutics 锰在金属免疫治疗中的应用：从分子靶点到材料工程和转化疗法

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2026-01-09 DOI: 10.1016/j.nantod.2025.102967

Jiale Xie , Siqi Wang , Haosen Zhao , Jiali Wang , Jie Liu , Ran Wei , Xudong Wang , Yujing Li

{"title":"Manganese in metalloimmunotherapy: From molecular targets to material engineering and translational therapeutics","authors":"Jiale Xie , Siqi Wang , Haosen Zhao , Jiali Wang , Jie Liu , Ran Wei , Xudong Wang , Yujing Li","doi":"10.1016/j.nantod.2025.102967","DOIUrl":"10.1016/j.nantod.2025.102967","url":null,"abstract":"<div><div>Immunotherapies play a crucial role in maintaining human health by modulating the immune system through the use of immune cells, antibodies, and vaccines. Among emerging therapeutic modalities, metal-based immunotherapy has shown promise by utilizing the immune-modulating properties of metals, metal ions, and metallic compounds for disease intervention. Specifically, Mn<sup>2 +</sup> has been demonstrated to potently activate the cGAS/STING signaling axis, a key pathway in innate immune activation for immunotherapeutic strategies. Notwithstanding these advantages, the clinical translation of free Mn<sup>2+</sup> is substantially hindered by three critical limitations: rapid in vivo degradation, poor transmembrane permeability as a hydrophilic cation, and potential cytotoxicity. To address these bottlenecks, advanced controlled-release technologies have been developed to enable spatiotemporal regulation of Mn<sup>2+</sup> in biological systems, thus improving therapeutic efficacy and reducing off-target effects. In this review, we delve into the intricate molecular mechanisms by which manganese ions regulate immune responses and explores the cutting-edge technologies employed in the fabrication of manganese-based materials. Then, we discussed the latest research on the use of manganese-based materials in antiviral, antibacterial and anticancer applications. Through its comprehensive comparative analysis, this review seeks to inspire next-generation research in manganese-based immunotherapy, unmasking its transformative potential across interdisciplinary frontiers and thereby catalyzing paradigm shifts in translational medicine.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102967"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulating the inverse VC/Pd heterostructure for high-performance electrocatalytic methanol oxidation 高性能电催化甲醇氧化中VC/Pd逆异质结构的调控

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2026-01-22 DOI: 10.1016/j.nantod.2026.102986

Ting Wu , Haolin Li , Wei Zhang , Jie Liu , Junning Zhao , Jialin Zhao , Shuangfei Cai , Rong Yang , Zhiyong Tang

{"title":"Modulating the inverse VC/Pd heterostructure for high-performance electrocatalytic methanol oxidation","authors":"Ting Wu , Haolin Li , Wei Zhang , Jie Liu , Junning Zhao , Jialin Zhao , Shuangfei Cai , Rong Yang , Zhiyong Tang","doi":"10.1016/j.nantod.2026.102986","DOIUrl":"10.1016/j.nantod.2026.102986","url":null,"abstract":"<div><div>Design of effective methanol oxidation reaction (MOR) electrocatalysts with fast reaction kinetics and exceptional CO resistance remains a grand challenge. Herein, we report an electron-restructuring strategy based on an inverse interfacial structure, by decorating the vanadium carbide nanoclusters (VC NCs) on hexagonal Pd nanosheets (NSs) for efficient MOR. The VC-decorated Pd NSs evolve into unique mulberry leaf-like structures (NMLs) with the jagged edges, enhancing active sites exposure and interfacial charge transfer. The VC<sub>0.01</sub>/Pd NMLs exhibit high mass activity (1768.44 A g<sub>Pd</sub><sup>−1</sup>), 23.6 and 6.4 times higher than Pd NSs and commercial Pd/C catalyst, respectively. The VC<sub>0.01</sub>/Pd NMLs also show high tolerance to CO poisoning. Theoretical calculations further reveal a strong VC-Pd interfacial interaction, modulating the Pd’s <em>d</em>-band center, reducing CO* adsorption, and enhancing OH* generation. The work shows that the construction of inverse VC-Pd interfaces is an effective approach to improve electrocatalytic performance of Pd catalysts for MOR.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102986"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A magnetic hyperthermia-chemodynamic nanoreactor with ascorbic acid-enhanced reactive oxygen species regulation for anti-thrombosis therapy 抗坏血酸增强活性氧调控的磁热化学动力学纳米反应器用于抗血栓治疗

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1016/j.nantod.2025.102951

Xuejiao Gong, Mengyun Yang, Xian Zheng, Hanyang Li, Guohao Li, Chendong Ji, Meizhen Yin

{"title":"A magnetic hyperthermia-chemodynamic nanoreactor with ascorbic acid-enhanced reactive oxygen species regulation for anti-thrombosis therapy","authors":"Xuejiao Gong, Mengyun Yang, Xian Zheng, Hanyang Li, Guohao Li, Chendong Ji, Meizhen Yin","doi":"10.1016/j.nantod.2025.102951","DOIUrl":"10.1016/j.nantod.2025.102951","url":null,"abstract":"<div><div>The synergy of reactive oxygen species (ROS) and heat has shown promise in enhancing thrombolysis by disrupting fibrin structure. However, precise control over the spatiotemporal distribution and dosage of ROS and heat at deep thrombus sites remains challenging. Here, we report an ascorbic acid (AA)-enhanced magnetic hyperthermia-chemodynamic therapy (MH-CDT) that exploits the concentration-dependent dual functionality of AA for precision thrombolysis. A dual-targeted magnetic nanoreactor (CMPV) was engineered to rapidly accumulate at the thrombus site via magnetic guidance and platelet membrane coating. AA facilitates the Fenton reaction for enhanced ROS generation to dissolve fibrin, while subsequently neutralizing excessive ROS to suppress inflammation during vascular repair. MH-CDT demonstrated thorough thrombus clearance and vascular recovery within 24 h without thrombosis recurrence in a mouse carotid artery thrombosis model. The combination between magnetic hyperthermia-induced fibrin disruption and AA-mediated ROS modulation enabled efficient thrombolysis while minimizing detrimental effects on the vascular endothelium. This AA-enhanced MH-CDT system provides a precise and effective thrombolytic strategy that overcomes depth limitations, showing promise for clinical translation.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102951"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcuma aromatica derived single-atom carbon dots with microenvironment responsible multi-enzyme activity for infected diabetic wound regeneration 姜黄衍生的单原子碳点微环境对糖尿病感染伤口再生的多酶活性有影响

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2026-01-17 DOI: 10.1016/j.nantod.2026.102982

Xiaoqin Hu , Shuyao Liu , Lanling Dai , Rui Wen , Bin Luo , Fang Lan , Yao Wu

{"title":"Curcuma aromatica derived single-atom carbon dots with microenvironment responsible multi-enzyme activity for infected diabetic wound regeneration","authors":"Xiaoqin Hu , Shuyao Liu , Lanling Dai , Rui Wen , Bin Luo , Fang Lan , Yao Wu","doi":"10.1016/j.nantod.2026.102982","DOIUrl":"10.1016/j.nantod.2026.102982","url":null,"abstract":"<div><div>The poor healing of diabetic wounds is attributed to infection, oxidative stress, and inflammation, representing a substantial clinical burden. Conventional nanozyme therapies are often constrained by inefficient catalytic cascades due to antagonistic or competitive interference. To overcome these limitations, we have developed a nanozyme composed of herb-derived carbon dots loaded with Fe single atoms (Fe SA@CDs) with the capability of mimicking multi-enzyme activity for ROS elimination and ROS generation in a pH-dependent manner, enabling an \"intelligent switching\" therapeutic function. Under acidic conditions, it displays NIR light-enhanced POD-like activity (up to 656.6 U/mg) to generate ROS for antibacterial applications. In neutral environment, it exhibits SOD-like activity (up to 2341.9 U/mg) and CAT-like activity to eliminate endogenous ROS for reducing oxidative stress and alleviating inflammation. In vivo experiments show that Fe SA@CDs can dynamically adjust its treatment strategy based on the pH changes in microenvironment: exerting strong antibacterial effects in the early acidic stage, shifting towards anti-inflammatory and regenerative functions in the neutral middle and late stages, thereby achieving a wound healing rate of 92.3 % on day 14. This study demonstrates a smart and microenvironment-responsive nanocatalytic therapy strategy for infected diabetic wound treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102982"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145972874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Biodegradable multimodal biomaterials with microenvironmental adaptability and orderly delivery of H2S and bFGF for the treatment of spinal cord injury” [Nano Today 66 (2026) 102890] “具有微环境适应性和有序输送H2S和bFGF的可生物降解多模态生物材料用于脊髓损伤治疗”的勘误表[Nano Today 66 (2026) 102890]

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-10-09 DOI: 10.1016/j.nantod.2025.102914

Junqing Huang , Jiamen Shen , Yu Huang , Yanfang Zhao , Yibo Ying , Yanran Bi , Liuxi Chu , Xinwang Ying , Qian Xu , Junpeng Xu , Ping Wu , Jiansong Ji , Zhouguang Wang

引用次数: 0

Dynamic hydration layer and ion-release synergy in coatings: Unraveling the key to sustainable anti-scaling during boiling and energy conservation 涂料中的动态水合层和离子释放协同作用：揭示沸煮过程中可持续防结垢和节能的关键

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-12-22 DOI: 10.1016/j.nantod.2025.102964

Ran Zhao , Jianmin Gu , Zhihao Shang , Xiaopeng Cheng , Chunxiao Liang , Desong Wang , Shutao Wang , Jingxin Meng

{"title":"Dynamic hydration layer and ion-release synergy in coatings: Unraveling the key to sustainable anti-scaling during boiling and energy conservation","authors":"Ran Zhao , Jianmin Gu , Zhihao Shang , Xiaopeng Cheng , Chunxiao Liang , Desong Wang , Shutao Wang , Jingxin Meng","doi":"10.1016/j.nantod.2025.102964","DOIUrl":"10.1016/j.nantod.2025.102964","url":null,"abstract":"<div><div>Scale deposition severely degrades the heat-transfer efficiency of industrial equipment, leading to substantial energy wastage. While several advanced scalephobic surfaces have been developed to mitigate scaling, their poor stability under harsh operating conditions hinders practical implementation. Herein, we report a dynamic hydration layer-synergistic ion-releasing (DHLIR) coating that exhibits exceptional energy-saving potential, enabled by ultrahigh scale resistance under boiling conditions. The DHLIR coating was facilely fabricated <em>via</em> a combined spraying and heat-treatment process, utilizing aluminum phosphate (AP) as the inorganic binder, titanium dioxide (TiO₂) nanoparticles as the structural reinforcement phase, and hexagonal boron nitride (<em>h</em>BN) nanosheets as the thermally conductive filler. Notably, the superior scalephobic performance of the DHLIR coating stems from two key mechanisms: the surface hydration layer minimizes mineral ion adsorption, while the released scale inhibitors reduce scale adhesion. Furthermore, the DHLIR coating demonstrates robust durability under extreme environments, including high temperatures, abrasion, and corrosive liquids. In a simulated industrial boiler setup, the DHLIR coating conserved approximately 15.3 % of energy compared to stainless steel. This work thus presents a promising strategy for anti-scaling and energy conservation in boiling environments.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102964"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145836870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclic D/L-peptides based nanoparticles regulates dendritic cell maturation and enhances anti-tumor immune response 基于环D/ l肽的纳米颗粒调节树突状细胞成熟并增强抗肿瘤免疫反应

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-11-18 DOI: 10.1016/j.nantod.2025.102931

Wei Hu , Jiaxi Xu , Mingchen Lv , Min Sun , Zhen Fan , Jianzhong Du

{"title":"Cyclic D/L-peptides based nanoparticles regulates dendritic cell maturation and enhances anti-tumor immune response","authors":"Wei Hu , Jiaxi Xu , Mingchen Lv , Min Sun , Zhen Fan , Jianzhong Du","doi":"10.1016/j.nantod.2025.102931","DOIUrl":"10.1016/j.nantod.2025.102931","url":null,"abstract":"<div><div>Immunotherapy offers enduring cancer treatment by activating the immune system to eliminate cancer cells, but faces challenges like tumor immune evasion and low immunogenicity. Chirality, crucial in biological interactions, remains underexplored for immune modulation. Inspired by the metal-binding domain of manganese superoxide dismutase, we develop a cyclic D/L peptide for chirality-driven immune activation. The cyclic <span>L</span>-Tyr-<span>D</span>-His-<span>L</span>-Asp-<span>D</span>-His (YhDh) peptide coordinates with Mn<sup>2+</sup> to self-assemble into nanoparticles, cloak with tumor cell membranes for homologous targeting. Compared to all-L or all-D peptides, YhDh nanoparticles promote costimulatory molecule expression on dendritic cells (DCs). Upon intravenous administration, they are oxidized at melanoma sites with tyrosinase overexpression, enabling photothermal-induced immunogenic cell death (ICD). Chiral peptides synergize with Mn<sup>2+</sup>-mediated cGAS-STING activation and ICD, enhancing DC maturation and T cell infiltration (4.36- and 2.88-fold), suppressing tumor metastasis while establishing immune memory. Such chiral cyclic peptides offer a novel strategy for immune activation by regulating peptide chirality.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102931"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electronic cloud-regulation strategy enabling rapid and sensitive near-infrared detection of ONOO⁻ for dynamic monitoring of ferroptosis-mediated drug-induced liver injury 电子云调节策略，实现ONOO的快速和灵敏的近红外检测，用于动态监测铁中毒介导的药物性肝损伤

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-09-12 DOI: 10.1016/j.nantod.2025.102900

Yongchuang Li , Haiyue Liu , Yuru Liu , Shaowei Wang , Caixia Yin , Fangjun Huo

{"title":"Electronic cloud-regulation strategy enabling rapid and sensitive near-infrared detection of ONOO⁻ for dynamic monitoring of ferroptosis-mediated drug-induced liver injury","authors":"Yongchuang Li , Haiyue Liu , Yuru Liu , Shaowei Wang , Caixia Yin , Fangjun Huo","doi":"10.1016/j.nantod.2025.102900","DOIUrl":"10.1016/j.nantod.2025.102900","url":null,"abstract":"<div><div>Drug-induced liver injury (DILI) is caused by hepatotoxic effects resulting from drug metabolism. Extensive studies have demonstrated a close association between DILI progression and ferroptosis, a process characterized by redox imbalance triggered by lipid peroxidation. As a key product of redox imbalance and a critical biomarker of DILI, peroxynitrite (ONOO<sup>-</sup>) plays a pivotal regulatory role in ferroptosis. To elucidate the precise mechanism of ONOO<sup>-</sup> in ferroptosis-mediated DILI, there is an urgent need for ONOO<sup>-</sup> fluorescent probes with high specificity, sensitivity and signal-to-noise ratio. This study innovatively modified the traditional pyridine hemicyanine fluorophore into a quinoline hemicyanine structure, achieving a red-shifted fluorescence emission wavelength through extended conjugation and enhanced electron delocalization. Systematic site screening identified diphenyl phosphate ester as the optimal reaction site, demonstrating exceptional specificity, sensitivity and 75 s response characteristics. By conjugating the optimized fluorophore with the reaction site via nucleophilic substitution, we successfully developed a novel ratiometric fluorescent probe, <strong>zt-4</strong>. Given the remarkable similarities in pathological mechanisms (including signaling pathways, regulatory nodes, and biomarkers) between osteoarthritis (OA) and DILI, we first validated the imaging performance of <strong>zt-4</strong> in a complex inflammatory OA Model. Subsequently, we applied probe <strong>zt-4</strong> to analyze ferroptosis-mediated DILI model at both cellular and murine levels. For the first time, our study revealed that the ferroptosis pathway dynamically regulates ONOO<sup>-</sup> levels in DILI, elucidating its molecular mechanism. These findings provide new theoretical foundations and intervention strategies for DILI treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102900"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0