Nano Today最新文献

{"title":"Robust ferroelectric and low coercive field in ZrO2 thin film through wide chemical-processing window","authors":"Xiuqiao Liu ,&nbsp;Hangren Li ,&nbsp;Dongxing Zheng ,&nbsp;Jie Tu ,&nbsp;Guoqiang Xi ,&nbsp;Xudong Liu ,&nbsp;Rong Wu ,&nbsp;Dongfei Lu ,&nbsp;Qingxiao Wang ,&nbsp;Xixiang Zhang ,&nbsp;Jianjun Tian ,&nbsp;Linxing Zhang","doi":"10.1016/j.nantod.2024.102470","DOIUrl":"10.1016/j.nantod.2024.102470","url":null,"abstract":"<div><p>Fluorite-based ferroelectric thin films offer significant potential as candidates for next-generation non-volatile memory logic devices due to their excellent compatibility with existing silicon-based semiconductor technology. However, the challenge lies in the complex preparation of stable fluorite based ferroelectric thin films, as several metastable phases typically exist under narrow and unpredictable experimental conditions, such as harsh temperature, specific thickness, unique strain conditions <em>et al</em>. Here, stable and cost-effective ZrO₂ ferroelectric thin film with tetragonal-orthorhombic-monoclinic phase transition can be fabricated in a wide chemical-processing window. Notably, within a considerable temperature range (∼200 °C) and thickness range (∼250 nm), the ZrO₂ films show robust ferroelectric polarization with a peak value of around 15 μC/cm², comparable to previous reports. The stable ferroelectric phase range can be controlled by adjusting oxygen content and implementing strain engineering. Intriguingly, we further achieve the highest remanent polarization of 20.15 μC/cm² and the lowest coercive field of 1.18 MV/cm by a combination of annealing times and strain engineering. Synchrotron-based X-ray absorption spectroscopy has revealed oxygen tetrahedral distortions, indicating the transition of from the tetragonal to orthorhombic phases. Furthermore, the migration of oxygen ions between the ferroelectric and antiferroelectric phase under electric field activation has been directly detected through integrated differential phase-contrast scanning transmission electron microscopy. This study significantly contributes to the further development of the fabrication procedure and enhances the understanding of the ferroelectric origin for ZrO₂-based fluorite ferroelectric thin films.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102470"},"PeriodicalIF":13.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entropy engineering: An innovative strategy for designing high-performance thermoelectric materials and devices","authors":"Raza Moshwan ,&nbsp;Xiao-Lei Shi ,&nbsp;Wei-Di Liu ,&nbsp;Jian Liu ,&nbsp;Zhi-Gang Chen","doi":"10.1016/j.nantod.2024.102475","DOIUrl":"10.1016/j.nantod.2024.102475","url":null,"abstract":"<div><p>Entropy engineering in thermoelectric materials involves a deliberate manipulation of entropy-related effects to boost performance. It revolves around designing materials to capitalize on entropy-driven changes, breaking conventional trade-offs between properties like electrical and thermal conductivity for improved efficiency. Entropy engineering fosters higher crystal symmetry, altering the Seebeck coefficient by augmenting degenerate valleys in the band structure. The introduction of significant mixing entropy mitigates strain energy, enhancing structural stability. Conversely, severe lattice distortion, atomic mass fluctuations, lattice anharmonicity, multiscale microstructures, and point defects lead to potent scattering of phonons, which suppresses thermal transport properties. This study comprehensively explores the effectiveness of entropy engineering in diverse compounds, aligning with the status and challenges in this field. These insights will guide researchers in refining material design and properties, advancing high-performance thermoelectric materials and devices to revolutionize energy conversion and stimulate sustainable technological advancements.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"58 ","pages":"Article 102475"},"PeriodicalIF":13.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1748013224003311/pdfft?md5=89698ce448bed1a383ec2dd4507eb835&pid=1-s2.0-S1748013224003311-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro blood-brain barrier: An in-depth quantitative analysis","authors":"Fazel Abdolahpur Monikh ,&nbsp;Šárka Lehtonen ,&nbsp;Jukka Kekäläinen ,&nbsp;Isabel Karkossa ,&nbsp;Seppo Auriola ,&nbsp;Kristin Schubert ,&nbsp;Alessandra Zanut ,&nbsp;Sanni Peltonen ,&nbsp;Jonna Niskanen ,&nbsp;Mandar Bandekar ,&nbsp;Martin von Bergen ,&nbsp;Jari T.T. Leskinen ,&nbsp;Arto Koistinen ,&nbsp;Sara Bogialli ,&nbsp;Zhiling Guo ,&nbsp;Jussi V.K. Kukkonen ,&nbsp;Chunying Chen ,&nbsp;Iseult Lynch","doi":"10.1016/j.nantod.2024.102466","DOIUrl":"10.1016/j.nantod.2024.102466","url":null,"abstract":"<div><p>Challenges in characterizing and quantifying nanoplastics within the human body hinder understanding of their transport, biotransformation, and potential for cellular penetration and barrier crossing. By implementing an innovative analytical workflow, including incorporation of gadolinium (Gd) as a tracer into the polymer matrix of nanoplastics, the fate of nanoplastics relative to an in vitro blood-brain barrier (BBB) model is elucidated in the absence or presence of a biomomolecule corona. The nanoplastics were incubated in human plasma for 5 min, 1 h, 6 h, and 24 h, after which the absorbed proteins and lipids (biocorona) were determined. A total of 268 proteins were identified in the biological coronas on polystyrene (PS) and polyvinyl chloride (PVC) nanoplastics, with the initial compositions being broadly similar on both PS and PVC. Both nanoplastics exhibited a strong affinity for phosphatidylcholines (PC) and lysophosphocholines (LPC) from human plasma. The inherent chemical composition of the nanoplastics plays a pivotal role in the corona’s evolution over time. Human induced pluripotent stem cell (iPSC)-derived endothelial cells (iECs) and astrocytes were exposed for 2 h to 5 µg L⁻¹ of pristine nanoplastics or nanoplastics covered with a biological corona (following incubation in plasma for 6 h). A relatively low concentration of PS and PVC nanoplastics was determined to be present within the cellular layer of the BBB. The number of PVC nanoplastics crossing the BBB was higher than the number of PS nanoplastics. The presence of a biological corona on these particles decreases their uptake and transcytosis. This understanding might further the development of preventive measures or therapeutic strategies to counteract potential nanoplastic-induced neurotoxicity, and provide a foundation for development of <em>in silico</em> models to predict the neurotoxic implications of nanoplastics.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102466"},"PeriodicalIF":13.2,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1748013224003220/pdfft?md5=43ab2f5962b37350624c06b3d8863a69&pid=1-s2.0-S1748013224003220-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confined PMo6W6 for energy storage","authors":"Yuanyuan Yan ,&nbsp;Xun Cao ,&nbsp;Chongji Wang ,&nbsp;Jijian Liu ,&nbsp;Longyi Fu ,&nbsp;Yang Yang ,&nbsp;Tian Wang ,&nbsp;Yu Lu ,&nbsp;Weifeng Liu ,&nbsp;Xuguang Liu ,&nbsp;Rongyan Wang ,&nbsp;Jiadong Zhou ,&nbsp;Meiling Wang","doi":"10.1016/j.nantod.2024.102476","DOIUrl":"10.1016/j.nantod.2024.102476","url":null,"abstract":"<div><p>Mixed-addenda polyoxometalate (e.g., PMo_<em>x</em>W_{12-<em>x</em>}) by “orbital engineering” allows the functionalization of the single-addenda cluster surface, which offers new electronic properties. However, the well-known agglomeration phenomenon greatly limits the full understanding of its unique redox properties. It makes sense to fully stimulate the intrinsic multi-electron activity of mixed-addenda polyoxometalate by confining engineering to apply in energy technology. With the verification of potential candidate PMo₆W₆ possessing remarkable stability with fully exposed activity sites in a confined state by theoretical analysis, we achieve the precise confinement of the single PMo₆W₆ molecule in porous carbon (PC) with a matched pore aperture (PMo₆W₆@PC). As a result, PMo₆W₆@PC-based supercapacitor shows high energy densities of 0.308 mWh cm⁻² at power densities of 43.2 mW cm⁻², outperforming most polyoxometalate-based supercapacitors. Moreover, the device exhibits a capacity retention of over 80.4 % at 8 mA cm⁻² after 8000 cycles. This improved electrochemical redox activity may be ascribed to the strong orbital electronic coupling between W and Mo atoms of PMo₆W₆ by confinement engineering. This work proves that the confined PMo₆W₆ can maximize the advantages of PMo₁₂O₄₀ and PW₁₂O₄₀, which provides a theoretical basis for other mixed-addenda polyoxometalate species.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102476"},"PeriodicalIF":13.2,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Size and surface-dependent phase transition temperature in Cu2Se nanobridges","authors":"Ziyang Huang ,&nbsp;Renhui Jiang ,&nbsp;Pei Li ,&nbsp;Xi Liu ,&nbsp;Guoxujia Chen ,&nbsp;Ligong Zhao ,&nbsp;Lei Li ,&nbsp;Peili Zhao ,&nbsp;Weiwei Meng ,&nbsp;Shuangfeng Jia ,&nbsp;He Zheng ,&nbsp;Jianbo Wang","doi":"10.1016/j.nantod.2024.102460","DOIUrl":"10.1016/j.nantod.2024.102460","url":null,"abstract":"<div><p>The critical phase transition temperature (<em>Tc</em>) of Cu₂Se thermoelectric nanomaterials has been a focal point of extensive research, yet the quantification of surface energy on <em>Tc</em> is frequently ignored. In this paper, we systematically investigate the impact of both the width/thickness and surface configuration of Cu₂Se nanobridges (NBs) on <em>Tc</em>. We find that the <em>Tc</em> decreases with size reduction, which becomes particularly accelerated when the size decreases to a few nanometers. Additionally, the NBs with higher energy surfaces exhibit lower <em>Tc</em>. Then we propose an optimized thermodynamic model to quantify the combined effect of size and surface energy on <em>Tc</em> in Cu₂Se NBs, which provides an approach to predict <em>Tc</em> in Cu₂Se and other thermoelectric nanomaterials. Our study facilitates the understanding of the dependence of <em>Tc</em> on size and surface in Cu₂Se, with an eye towards the stable room temperature thermoelectric applications of Cu₂Se nanomaterials.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"58 ","pages":"Article 102460"},"PeriodicalIF":13.2,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142096241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expandable rotational origami nano-boxes made by giant shape amphiphile","authors":"Jia Chen ,&nbsp;Haoru Zhao ,&nbsp;Dandan Gu ,&nbsp;Yangshuang Xiang ,&nbsp;Xiaoze Jiang ,&nbsp;Chien-Lung Wang ,&nbsp;Liping Zhu ,&nbsp;Bin Sun ,&nbsp;Meifang Zhu","doi":"10.1016/j.nantod.2024.102458","DOIUrl":"10.1016/j.nantod.2024.102458","url":null,"abstract":"<div><p>Dynamic cavity is widespread in living matter and supramolecular scaffolds. Generally speaking, flexible building block as a segment is used to realize dynamic cavities building in artificial molecules and materials. However, the incorporation of rigid synthetic supramolecular scaffolds with flexible cavity motion remains rare. Inspired by rotational origami patterns, giant shape amphiphile (GSA), POSS-NDI-POSS (PNP), assembled into an origami nano-box with feature of rotational expansion. The open/close of cavity and size control of PNP host can be adjusted by rotational offset between adjacent PNP in supramolecule entities. The rotational offset of 150°, 130° and 0° were observed when the host nano-box presented close, half-open and fully-open state, respectively. The rotational expansion of PNP trigged by gaseous arenes makes PNP as a novel nonporous crystal. Compared with conformation change in flexible building segment, rotational expansion in acyclic host (PNP) provides a new strategy for the development of rigid segment to build adaptive host-guest recognition.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"58 ","pages":"Article 102458"},"PeriodicalIF":13.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional hydrogel membranes for boosting osmotic energy conversion: Spatial confinement and charge regulation induced by zirconium ion crosslinking","authors":"Caiqin Wu ,&nbsp;Jian Wang ,&nbsp;Rong Wu ,&nbsp;Huan Zeng ,&nbsp;Xianfei Chen ,&nbsp;Chenling Yao ,&nbsp;Jialing Zhou ,&nbsp;Xiang-Yu Kong ,&nbsp;Liping Wen ,&nbsp;Lei Jiang","doi":"10.1016/j.nantod.2024.102468","DOIUrl":"10.1016/j.nantod.2024.102468","url":null,"abstract":"<div><p>Ion-exchange membranes have been widely used to harvest osmotic energy in the past decades. However, conventional ion-exchange membranes suffer from low output power and poor conversion efficiency due to their limited pores and high membrane resistance. Herein, a sodium alginate (SA)/3-sulfopropyl acrylate potassium salt (SPAK) hydrogel membrane which has good cationic selectivity and can effectively harvest osmotic energy is designed, yielding a maximum power density of 16.44 W/m² under a 50-fold NaCl concentration gradient and 36.85 W/m² with ion selectivity of 0.73 at 500-fold. Furthermore, by introducing Zr⁴⁺, post-crosslinking reaction was employed to prepare tougher hydrogel membranes at room temperature for breaking a trade-off between selectivity and permeability, boosting a maximum power density up to 25.07 W/m² under a 50-fold NaCl concentration gradient and 121.66 W/m² with a high cation selectivity of 0.87 at 500-fold. Importantly, the resultant SA/SPAK/Zr⁴⁺ membrane reveals excellent osmotic energy harvesting property with the largest thickness of 500 μm, exceeding other reported porous nanofluidic membranes. Theoretical calculations correlate the enhanced power density of SA/SPAK/Zr⁴⁺ membranes with the enriched Cl^- and smaller pore size after the introduction of Zr⁴⁺. This work paves an avenue to design and develop the 3D hydrogel membranes for high-performance osmotic energy generators.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"58 ","pages":"Article 102468"},"PeriodicalIF":13.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon nitride nanosheets induce pulmonary surfactant deposition via dysfunction of alveolar secretion and clearance","authors":"Mingyue Wang ,&nbsp;Xiaoya Ji ,&nbsp;Longwei Wang ,&nbsp;Xin Li ,&nbsp;Huan Lin ,&nbsp;Jianzhong Zhang ,&nbsp;Haonan Li ,&nbsp;Yongfeng Lin ,&nbsp;Leon Gradon ,&nbsp;Yuxin Zheng ,&nbsp;Jing Liu ,&nbsp;Jinglong Tang","doi":"10.1016/j.nantod.2024.102457","DOIUrl":"10.1016/j.nantod.2024.102457","url":null,"abstract":"<div><p>Graphitic carbon nitride is a new type of carbon-based nanomaterial with superior properties and great potential for application, which raised great concerns about their environmental and occupational exposure. Graphitic carbon nitride has been reported to accumulate in the lung potentially, however, the respiratory hazard effect of graphitic carbon nitride is still unknown. In the present study, we reported that graphitic carbon nitride (g-CN) and its doped variant sulfur doped graphitic carbon nitride (S-g-CN) nanosheets inhalation induced pulmonary inflammation, increased the production of pulmonary surfactant in alveolar type II epithelial cells, accompanied by the upregulation of lipids transporter expression levels in alveolar macrophages to clear excessive pulmonary surfactant in the alveolar. Further investigation found that the internalization of g-CN and S-g-CN prevented lipid phagocytosis and metabolic processes in alveolar macrophages, ultimately leading to the deposition of proteins and phospholipids in the lung. Furthermore, we found that g-CN was more robust in inhalation toxicity compared to sulfur doped form, which meant the doping of sulfur in graphitic carbon nitride reduced hazardous effects on the respiratory system. In summary, our study demonstrated that inhalation of graphitic carbon nitride nanosheets caused the deposition of pulmonary surfactants in lung, providing an insightful reference for pulmonary toxicity assessment of graphitic carbon nitride.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"58 ","pages":"Article 102457"},"PeriodicalIF":13.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142083938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA self-assembly-mediated high drug-antibody ratio ADC platform for targeted tumor therapy and imaging","authors":"Shijie Jin ,&nbsp;Xinlei Zhuang ,&nbsp;Yingchun Xu ,&nbsp;Guangjun Nie ,&nbsp;Shuqing Chen ,&nbsp;Liqiang Pan","doi":"10.1016/j.nantod.2024.102459","DOIUrl":"10.1016/j.nantod.2024.102459","url":null,"abstract":"<div><p>Antibody-drug conjugates (ADCs) achieve therapeutic effects through toxin delivery inside cells, targeting high-abundance antigens. However, tumor heterogeneity and the low abundance of tumor-specific antigens underscore the urgent requirement for developing a flexible, multifunctional, and high-capacity drug-delivery platform. The current study developed a self-assembled ADC platform called the high drug–antibody-ratio ADC (HD-ADC). Cytotoxic payloads were efficiently conjugated into a 12-arm deoxyribonucleic acid (DNA) branched junction via DNA-mediated precise self-assembly to achieve a high drug–antibody ratio (DAR). Anti-EGFR HD-ADC showed strong efficacy in causing cytotoxicity and suppressing tumor growth in an A431 xenograft mouse model. Furthermore, the Cy5-conjugated HD-ADC platform was a simple and effective method for improving fluorescent signal detection, enabling the detection of targets—such as neoantigens—with ultralow-expression levels. The HD-ADC platform supports the assembly of various functional components, providing the foundation for usage across multiple antibody-mediated targeted therapies and diagnostics.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"58 ","pages":"Article 102459"},"PeriodicalIF":13.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1748013224003153/pdfft?md5=ba182b8c71f110f17b50dee42e85f3bf&pid=1-s2.0-S1748013224003153-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142083939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of drug-free sodium bicarbonate nanoparticles with high water-tolerance for gas therapy to selectively induce non-apoptotic death of cancer cells","authors":"Jinlian He,&nbsp;Xinyi Dai,&nbsp;Ziyang Wang,&nbsp;Jingjie Ye,&nbsp;Jiangbo Wang,&nbsp;Jun Feng,&nbsp;Xian-Zheng Zhang","doi":"10.1016/j.nantod.2024.102463","DOIUrl":"10.1016/j.nantod.2024.102463","url":null,"abstract":"<div><p>Developing drug-free nanotherapeutics is extremely appealing provided they could achieve effective therapeutic performances. This study proposes a sodium bicarbonate-dependent gas therapy modality targeting fragile lysosomes of cancer cells through carbon dioxide-induced lysosomal rupture. Interestingly, we reveal that this gas therapy induces cell death through the combination of necrosis, pyroptosis and ferroptosis, rather than the conventional apoptosis pathway. Notably, the high water-solubility of sodium bicarbonate presents a significant challenge in engineering its nanotherapeutics that require long-term water-tolerance for its intravenous delivery. To address this issue, an EPDPPP approach is here developed under aqueous conditions. Without any anticancer drugs, the sodium bicarbonate nanoparticles alone can selectively kill cancer cells with high specificity. Thanks to the high water tolerance, the sodium bicarbonate nanoparticles coated with cancer cell membranes have shown favorable performance in targeting and inhibiting tumors after intravenous administration. This water-tolerant sodium bicarbonate nanoplatform is expected to have potential applications in various medical fields, including the targeted gas therapy. Additionally, this study may suggest a viable direction for developing water-tolerant nanoparticles derived from water-soluble inorganic salts.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"58 ","pages":"Article 102463"},"PeriodicalIF":13.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}