Nano Today最新文献

{"title":"Plasmonic alloys enhance metabolic fingerprints for rapid diagnosis and classification of myocardial infarction","authors":"Ziyue Zhang ,&nbsp;Yong Li ,&nbsp;Ruimin Wang ,&nbsp;Shouzhi Yang ,&nbsp;Peng Li ,&nbsp;Kun Zhao ,&nbsp;Yang Gu ,&nbsp;Kexin Meng ,&nbsp;Jinshuang Li ,&nbsp;Jun Pu ,&nbsp;Xiaoxiang Yan ,&nbsp;Sai Gu ,&nbsp;Haiyang Su ,&nbsp;Xiangqing Kong ,&nbsp;Kun Qian","doi":"10.1016/j.nantod.2025.102702","DOIUrl":"10.1016/j.nantod.2025.102702","url":null,"abstract":"<div><div>Although cardiac troponin (cTn) is a recommended clinical biomarker of myocardial infarction (MI), it is inefficient for MI diagnosis requiring serial cTn measurements and is inaccurate for MI subtype identification. Advanced bioanalytical platforms commonly rely on materials with tailored structure and composition. Here, we construct porous PtAu alloys to effectively extract serum metabolic fingerprints (SMFs) via laser desorption/ionization mass spectrometry (LDI-MS), achieving accurate diagnosis and classification of MI by machine learning of SMFs. The PtAu alloys demonstrate enhanced metabolite detection, superior to the monometallic nanoparticles and organic matrix. It is attributed to the porous structure, enhanced photocurrent response, electromagnetic field, and photothermal conversion. Machine learning of SMFs yields diagnostic models with the area under curves (AUCs) of 0.941–1 for 604 subjects from multiple centers in a serum test, overcoming the clinical inefficiency for serial cTn measurements. In particular, our platform achieves accurate discrimination among patients with type 1 MI, type 2 MI, and myocardial injury, with a maximum AUC of 0.905, outperforming the cTn biomarker. Notably, the diagnosis and classification for MI can be finished within ∼30 min. Our platform has the potential to reduce time spent in the emergency department and improve treatment for MI.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102702"},"PeriodicalIF":13.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143591650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miniaturization and low energy consumption approach to magnetic particle imaging","authors":"Lin Fan ,&nbsp;Chengsong Wang ,&nbsp;Yushen Tian ,&nbsp;Doudou Lou ,&nbsp;Qianli Ma ,&nbsp;Ning Gu","doi":"10.1016/j.nantod.2025.102706","DOIUrl":"10.1016/j.nantod.2025.102706","url":null,"abstract":"<div><div>As an emerging application of superparamagnetic iron oxide nanoparticles, magnetic particle imaging (MPI) is considered a promising and competitive medical imaging technology. However, MPI is still in its infancy and most proposed devices require large amounts of power and occupy a significant physical footprint, hence miniaturization and energy reduction have been one of the research emphases and a crucial driving force for clinical translation. This review focuses on the novel technologies and design philosophies that lead to simplification, integration, reduced costs, and improved energy efficiency in MPI systems, including internal optimization strategies based on advanced electromagnetic modules development, integration optimization strategies orienting multifunctional and multimodal diagnostic and therapeutic equipment, and systematic optimization strategies that incorporate interdisciplinary approaches such as superconductivity and nanotechnology. Among those, internal design is the foundation, for instance, refining magnetic field designs, integrating various functional modules, and introducing advanced electromagnetic materials. From the perspective of reducing the overall size and energy consumption of medical equipment, MPI can be integrated with other diagnostic and therapeutic technologies, which not only fosters advanced methods but also saves on development and operational costs. Furthermore, the interdisciplinary approaches provide more effective solutions, that high-performed magnetic tracers and signal processing algorithms contribute to a lowered dependence on large-scale functional modules and strong-electromagnetic fields. This review offers a systematic and specialized discussion on the miniaturization and low energy consumption approaches, as well as a fresh perspective on the development status of MPI.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102706"},"PeriodicalIF":13.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143591651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypeptide nanomicelles co-deliver PLK1 and BCL-2/xL inhibitors for synergetic therapy of brain tumor","authors":"Yueyue Zhang ,&nbsp;Xiaofei Zhao ,&nbsp;Xin Wang,&nbsp;Siyu Wang,&nbsp;Zhiyuan Zhong,&nbsp;Chao Deng","doi":"10.1016/j.nantod.2025.102712","DOIUrl":"10.1016/j.nantod.2025.102712","url":null,"abstract":"<div><div>Molecular targeted therapy has revolutionized the clinical practice for various cancer patients. The therapeutic benefits vary greatly due to low bioavailability, insufficient accessibility on targets, and presence of intrinsic and acquired resistance. Restrained by additional blood-brain barrier (BBB), treatments of small molecule inhibitors in brain tumors have made less progress. Here, we find that ApoE peptide-decorated nanomicelles (ApoE-PM) based on phenylboronic acid-functionalized polypeptide mediate efficient co-delivery of polo-like kinase 1 (PLK1) and B-cell lymphoma-2/xL (BCL-2/xL) inhibitors to brain tumor. Nanomicelles exhibit exceptional stability, proportional co-loading and responsive release of small molecule inhibitors with diverse properties and molecular targets, by exploiting the B-N coordination and π-π stacking between phenylboronic acid groups and drugs. Notably, micelles decorated with ApoE peptide on the surface and loaded with volasertib and navitoclax at a weight ratio of 1/1 (ApoE-PMVN) reveals proficient BBB crossing, efficient internalization and strong synergistic antiproliferation effect in GL261 cells. In mice bearing orthotopic GL261 glioblastoma (GBM) model, ApoE-PMVN affords significant growth inhibition and markedly improved survival time via synergistic inhibition of PLK1, BCL-2/xL and myeloid cell leukemia 1 (MCL-1) targets. PM provides a versatile strategy for co-delivery of small molecule inhibitors, offering a potential for synergistic therapy of brain tumors.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102712"},"PeriodicalIF":13.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143591649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing oxygen vacancies in cerium oxide to narrow the gap between d and f band centers for efficient alkaline water oxidation","authors":"Yong Jiang ,&nbsp;Zhong Liang ,&nbsp;Hao Fu ,&nbsp;Guangtong Hai ,&nbsp;Yaping Du","doi":"10.1016/j.nantod.2025.102705","DOIUrl":"10.1016/j.nantod.2025.102705","url":null,"abstract":"<div><div>Rare earth oxides (REOs) hold a pivotal position in enhancing electrocatalytic performance, yet the comprehension of their underlying mechanisms poses significant challenges. In this study, REOs loaded with a ternary alloy, abundant in oxygen vacancies, were synthesized through a one-pot reduction method and exhibited remarkable oxygen evolution reaction (OER) activity. The interaction at the interface between Fe_0.3NiCo and CeO₂ induced substantial lattice distortion and modulated the oxygen vacancy concentration within the REOs. A unique electron transport channel, incorporating transition metal (3d) -oxygen vacancy (Vo) -rare earth (4 f) elements, was constructed at the interface, significantly boosting the OER activity of NiCo-CeO₂. Notably, a current density of 10 mA cm⁻² was achieved at a low overpotential of 151 mV. Comprehensive characterizations revealed that the interplay between the alloy and REOs regulated the oxygen vacancy concentration of the latter. <em>In-situ</em> attenuated total reflection infrared spectroscopy (ATR-IR) further confirmed that REOs facilitated the adsorption of O₂/-OH, thereby enhancing OER activity. Theoretical calculations also indicated that oxygen vacancies effectively shifted the d and f band centers near the Fermi level, promoting d-f electron exchange and ensuring efficient electron transfer. This study offers a novel perspective for the development of efficient RE-based catalysts.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102705"},"PeriodicalIF":13.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-situ L-TEM observations of dynamics of nanometric skyrmions and antiskyrmions","authors":"Licong Peng ,&nbsp;Fehmi Sami Yasin ,&nbsp;Kosuke Karube ,&nbsp;Naoya Kanazawa ,&nbsp;Yasujiro Taguchi ,&nbsp;Yoshinori Tokura ,&nbsp;Xiuzhen Yu","doi":"10.1016/j.nantod.2025.102698","DOIUrl":"10.1016/j.nantod.2025.102698","url":null,"abstract":"<div><div>Nanometer-scale magnetic skyrmions and antiskyrmions exhibit unique dynamical behaviors in response to external stimuli, which are critical for their applications in low-power-consumption spintronic devices. This review discusses recent advancements in <em>in-situ</em> Lorentz transmission electron microscopy (L-TEM) observations of skyrmion and antiskyrmion dynamics, and demonstrates the manipulation and evolution of these textures in various magnetic materials under electric, magnetic, and thermal stimuli. Specifically, the motion tracking of single skyrmions and their clusters, and the deformation and transformation of skyrmions has been demonstrated in chiral helimagnets FeGe, Co₉Zn₉Mn₂, and Co₁₀Zn₁₀ with precise application of electric currents. Skyrmions can undergo dynamic transitions in current-driven skyrmion motions, from pinned states to linear flows, and even exhibit deformation into elliptical shapes, underscoring their topological robustness and dynamic flexibility. In addition, the manipulation of single antiskyrmions and antiskyrmion-lattice phases in (Fe_0.63Ni_0.3Pd_0.07)₃P with <em>S</em>₄ symmetry is discussed, highlighting their high mobility and unique sliding capabilities along stripe domains at room temperature, facilitated by nanosecond pulsed electric currents. Finally, the temperature gradient-driven motion and topological transformation of elliptical skyrmions and antiskyrmions in this same material are investigated. The comprehensive insights gained from the L-TEM imaging technique are pivotal in advancing the design and functionality of next-generation skyrmion/antiskyrmion-based spintronic devices.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102698"},"PeriodicalIF":13.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lubricated hydrogel with STING-inhibiting EXOs protect the osteoarthritis by suppressing the senescent microenvironment","authors":"Gang Feng ,&nbsp;Yifan Wu ,&nbsp;Xinzi He ,&nbsp;Tingting Ye ,&nbsp;Shang Chi ,&nbsp;Xiaoxiao Ji ,&nbsp;Jiawei Kang ,&nbsp;Kaicheng Xu ,&nbsp;JinFeng Zhou ,&nbsp;Zhihui Xiang ,&nbsp;Wei Wang ,&nbsp;Yaping Li ,&nbsp;Yiying Qi","doi":"10.1016/j.nantod.2025.102688","DOIUrl":"10.1016/j.nantod.2025.102688","url":null,"abstract":"<div><div>Excessive friction and cellular senescence contribute to osteoarthritis (OA) development. However, synergistic treatments targeting these two causes of OA may have significant implications for OA. In this study, we propose a novel strategy for exosome delivery encapsulated an injectable and lubricated hydrogel to synchronously reduce the excessive friction and the accumulation of aged chondrocytes. A cartilage-targeting peptide HABP-PEG-COLBP was employed to achieve a stable and efficient lubrication. The zwitterions of phosphatidylcholine lipids secreted by the synovial membrane of the joint can adsorb water molecules, forming a hydrated layer around the charge. Moreover, the exosomes derived from bone marrow stem cell (BMSCs) were engineered with a chondrocyte affinity peptide (CAP) in the out membrane and si-STING in the exosome to reshape the senescence microenvironment. Furthemore, the in vivo data showed that the hydrogel/exosome delivery system successfully can alleviate the joint wear and rejuvenate chondrocytes to reverse the development of OA. The HD-T@CAP-Exos-siSTING gels can provide efficient lubrication and potentially alleviate friction-related diseases such as osteoarthritis.</div></div><div><h3>Teaser</h3><div>An injectable hydrogel delivering exosomes rejuvenates chondrocytes and reduces mechanical stress, presenting a potential osteoarthritis treatment strategy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102688"},"PeriodicalIF":13.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An enzyme-activated and structural transformable supramolecular oncolytic peptide for efficient cancer immunotherapy through systemic administration","authors":"Zhenghao Zhang ,&nbsp;Xingjie Hu ,&nbsp;Yuhan Hu ,&nbsp;Shengyi Zhang ,&nbsp;Yinghao Ding ,&nbsp;Xiangyang Zhang ,&nbsp;Zhimou Yang ,&nbsp;Zhi-Wen Hu","doi":"10.1016/j.nantod.2025.102699","DOIUrl":"10.1016/j.nantod.2025.102699","url":null,"abstract":"<div><div>Oncolytic peptides have emerged as a promising oncolytic therapeutic. However, oncolytic peptides face numerous challenges when administrated systemically, including untargeted toxicity, poor bioactivity, and inadequate stability. We here present an innovative strategy to develop self-assembled supramolecular oncolytic peptides suitable for systemic intravenous administration. D2RP (Nap-G^DF^DF^DY-RR-^DKRFYVVMWK^DK) comprises and significantly endows PKHB1 (^DKRFYVVMWK^DK; an endogenous ligand of CD47) with powerful oncolytic activities by self-assembling into positive-charged and α-helix-enriched membrane-lytic nanofibrils. Subsequently, two phosphorylated precursors of D2RP at ^DY4 and Y10, namely pD2RP (Nap-G^DF^DFp^DY-RR-^DKRFYVVMWK^DK) and D2RpP (Nap-G^DF^DF^DY-RR-^DKRFpYVVMWK^DK), respectively, are tailored to generate membrane-lytic nanofibrils in alkaline phosphatase (ALP)-responsive manner. Both pD2RP and D2RpP are biocompatible, while they preorganize into different states and proceed with varied dephosphorylation processes to generate membrane-lytic nanofibrils differing in supramolecular structures and oncolytic activities. Mechanistically, pD2RP and D2RpP remain inactive until dephosphorylated; at this point, their membrane-lytic activities are activated through structural reconfiguration upon reaching the ALP-enriched tumor lesions. When administrated intravenously, pD2RP outperforms D2RpP in tumor rejection by inducing much more potent immune cell death and evoking robust systemic anti-tumor immune responses. This study provides a new paradigm for tailoring supramolecular oncolytic peptides for systemic intravenous administration and a valuable strategy for optimizing their anti-tumor efficacy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102699"},"PeriodicalIF":13.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium nanoparticles restrain recurrence of cervical cancer in drug-free period by inhibiting the expression of ABC transporters","authors":"Ting Liu ,&nbsp;Shuya Pan ,&nbsp;Qingfeng Zhou ,&nbsp;Ziyi Yang ,&nbsp;Zihan Zhang ,&nbsp;Hejing Liu ,&nbsp;Lizhen He ,&nbsp;Jingyuan Lan ,&nbsp;Ying Hua ,&nbsp;Tianfeng Chen ,&nbsp;Xueqiong Zhu","doi":"10.1016/j.nantod.2025.102692","DOIUrl":"10.1016/j.nantod.2025.102692","url":null,"abstract":"<div><div>Cervical cancer remains the one of the most frequent malignant tumors in women around the world. Cisplatin-based chemotherapy is a prevalent treatment for advanced cervical cancer, but it has significant side effects that necessitate drug-free periods during treatment cycles. Unfortunately, tumors often relapse during these intervals, highlighting the need for strategies to prevent recurrence. In the present study, the biological changes in cervical cancer cells following the withdrawal of cisplatin chemotherapy were investigated. Afterwards, the application of selenium nanoparticles (SeNPs) modified with lentinan (LNT) to address tumor recurrence during these drug-free periods was explored. Specifically, <em>in vitro</em> experiments demonstrated that SeNPs@LNT effectively inhibited tumor recurrence by promoting DNA damage, inducing apoptosis, and disrupting mitochondrial membrane potential. Additionally, <em>in vivo</em> experiments showed that SeNPs@LNT had a strong antitumor effect on cervical cancer during the drug-free period. It also remarkable that SeNPs@LNT might prevent the development of drug resistance by suppressing the expression of the ABC transporter and VEGF. Our findings suggest that SeNPs@LNT is a promising candidate for maintaining chemotherapy efficacy during the drug-free intervals of cisplatin treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102692"},"PeriodicalIF":13.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143528976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Splenic response to protein corona of nanoparticles in vivo","authors":"Can Chen ,&nbsp;Yueping Li ,&nbsp;Dandan Zhou ,&nbsp;Jiada Fan ,&nbsp;Xuelan Hu ,&nbsp;Ruru Zhang ,&nbsp;Jianxian Ge ,&nbsp;Xiaoyi Cao ,&nbsp;Haodi Qi ,&nbsp;Ning Wang ,&nbsp;Lei Chen ,&nbsp;Baoxing Huang ,&nbsp;Jianfeng Zeng ,&nbsp;Mingyuan Gao","doi":"10.1016/j.nantod.2025.102676","DOIUrl":"10.1016/j.nantod.2025.102676","url":null,"abstract":"<div><div>The spleen is a meeting point between antigens transported by the blood stream and the immune apparatus responsible for mounting the host response. However, the interactions between nanomaterials and the spleen, significantly influenced by the protein corona formed on the surface of nanomaterials, are often overlooked. To address this issue, Fe₃O₄ nanoparticles with two distinct surface coatings, <em>i.e.</em>, diphosphonate-polyethylene glycol (DP-PEG), and diphosphonate-<em>ε</em>-aminocaproic acid (DP-EACA), were selected for a comprehensive investigation into the impacts of protein corona on the immune response within the spleen, attempting to gain a deeper understanding on how protein corona disturbs the immune response in the spleen to enrich the knowledge about the surface chemistry of nanoparticles. Additionally, carboxymethyl dextran (CM-DEX)-modified Fe₃O₄ nanoparticles, a generic form of the clinically used nanodrug Ferumoxytol, were chosen as a reference. The protein adsorption and its impacts on immune cells, gene expression, and metabolites in the spleen were investigated over a 28-day period. Our findings indicated that the opsonins carried by Fe₃O₄ nanoparticles were strongly correlated with immune response and metabolic disturbances in the spleen. However, DP-PEG coating exhibited remarkable resistance against protein adsorption and minimized spleen perturbation, highlighting its outstanding potential for clinical applications. All these findings are believed very valuable for developing clinically translatable drugs based on nanomaterials.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102676"},"PeriodicalIF":13.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered renal-targeting nanozyme achieves sequential treatment of AKI through ROS clearance and immune modulation","authors":"Zhiwen Wang ,&nbsp;Yue Xie ,&nbsp;Mingcun Hu,&nbsp;Min Yang,&nbsp;Xingjian Zou,&nbsp;Chun Zhang","doi":"10.1016/j.nantod.2025.102685","DOIUrl":"10.1016/j.nantod.2025.102685","url":null,"abstract":"<div><div>Effective countermeasures for acute kidney injury (AKI) remain unsatisfactory. During AKI progression, the timely and appropriate transition of macrophages from pro-inflammatory to anti-inflammatory states is critical for resolving acute inflammation and promoting tissue repair. Timely clearing of excess reactive oxygen species (ROS) and promotion of M2 polarization of macrophages are key determinants of AKI progression. Accordingly, we report an engineered renal-targeting nanozyme constructed from a novel two-dimensional nanomaterial, MXene nanosheets, via surface conjugation of the anticomplement component 5a aptamer (ac5a-Apt) and magnesium ions (Mg^2 +). After AKI, the engineered nanozyme can not only target the kidneys but also navigates to inflammatory areas under the guidance of the ac5a-Apt, clear excessive ROS, inhibits the C5a-C5aR complement system activation and promote M2 polarization of macrophages. Importantly, after MXene reacts with ROS and degrades, the surface-loaded Mg²⁺ is released, further suppressing the MAPK/ NF-κB signaling pathway to achieve sequential therapy. The engineered renal-targeting nanozyme offers a novel strategy based on ROS clearance and immune modulation for sequential AKI treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102685"},"PeriodicalIF":13.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}