Nano Today最新文献_第9页

Corrigendum to “Biodegradable multimodal biomaterials with microenvironmental adaptability and orderly delivery of H2S and bFGF for the treatment of spinal cord injury” [Nano Today 66 (2026) 102890] “具有微环境适应性和有序输送H2S和bFGF的可生物降解多模态生物材料用于脊髓损伤治疗”的勘误表[Nano Today 66 (2026) 102890]

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-10-09 DOI: 10.1016/j.nantod.2025.102914

Junqing Huang , Jiamen Shen , Yu Huang , Yanfang Zhao , Yibo Ying , Yanran Bi , Liuxi Chu , Xinwang Ying , Qian Xu , Junpeng Xu , Ping Wu , Jiansong Ji , Zhouguang Wang

引用次数: 0

Dynamic hydration layer and ion-release synergy in coatings: Unraveling the key to sustainable anti-scaling during boiling and energy conservation 涂料中的动态水合层和离子释放协同作用：揭示沸煮过程中可持续防结垢和节能的关键

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-12-22 DOI: 10.1016/j.nantod.2025.102964

Ran Zhao , Jianmin Gu , Zhihao Shang , Xiaopeng Cheng , Chunxiao Liang , Desong Wang , Shutao Wang , Jingxin Meng

{"title":"Dynamic hydration layer and ion-release synergy in coatings: Unraveling the key to sustainable anti-scaling during boiling and energy conservation","authors":"Ran Zhao , Jianmin Gu , Zhihao Shang , Xiaopeng Cheng , Chunxiao Liang , Desong Wang , Shutao Wang , Jingxin Meng","doi":"10.1016/j.nantod.2025.102964","DOIUrl":"10.1016/j.nantod.2025.102964","url":null,"abstract":"<div><div>Scale deposition severely degrades the heat-transfer efficiency of industrial equipment, leading to substantial energy wastage. While several advanced scalephobic surfaces have been developed to mitigate scaling, their poor stability under harsh operating conditions hinders practical implementation. Herein, we report a dynamic hydration layer-synergistic ion-releasing (DHLIR) coating that exhibits exceptional energy-saving potential, enabled by ultrahigh scale resistance under boiling conditions. The DHLIR coating was facilely fabricated <em>via</em> a combined spraying and heat-treatment process, utilizing aluminum phosphate (AP) as the inorganic binder, titanium dioxide (TiO₂) nanoparticles as the structural reinforcement phase, and hexagonal boron nitride (<em>h</em>BN) nanosheets as the thermally conductive filler. Notably, the superior scalephobic performance of the DHLIR coating stems from two key mechanisms: the surface hydration layer minimizes mineral ion adsorption, while the released scale inhibitors reduce scale adhesion. Furthermore, the DHLIR coating demonstrates robust durability under extreme environments, including high temperatures, abrasion, and corrosive liquids. In a simulated industrial boiler setup, the DHLIR coating conserved approximately 15.3 % of energy compared to stainless steel. This work thus presents a promising strategy for anti-scaling and energy conservation in boiling environments.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102964"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145836870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclic D/L-peptides based nanoparticles regulates dendritic cell maturation and enhances anti-tumor immune response 基于环D/ l肽的纳米颗粒调节树突状细胞成熟并增强抗肿瘤免疫反应

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-11-18 DOI: 10.1016/j.nantod.2025.102931

Wei Hu , Jiaxi Xu , Mingchen Lv , Min Sun , Zhen Fan , Jianzhong Du

{"title":"Cyclic D/L-peptides based nanoparticles regulates dendritic cell maturation and enhances anti-tumor immune response","authors":"Wei Hu , Jiaxi Xu , Mingchen Lv , Min Sun , Zhen Fan , Jianzhong Du","doi":"10.1016/j.nantod.2025.102931","DOIUrl":"10.1016/j.nantod.2025.102931","url":null,"abstract":"<div><div>Immunotherapy offers enduring cancer treatment by activating the immune system to eliminate cancer cells, but faces challenges like tumor immune evasion and low immunogenicity. Chirality, crucial in biological interactions, remains underexplored for immune modulation. Inspired by the metal-binding domain of manganese superoxide dismutase, we develop a cyclic D/L peptide for chirality-driven immune activation. The cyclic <span>L</span>-Tyr-<span>D</span>-His-<span>L</span>-Asp-<span>D</span>-His (YhDh) peptide coordinates with Mn<sup>2+</sup> to self-assemble into nanoparticles, cloak with tumor cell membranes for homologous targeting. Compared to all-L or all-D peptides, YhDh nanoparticles promote costimulatory molecule expression on dendritic cells (DCs). Upon intravenous administration, they are oxidized at melanoma sites with tyrosinase overexpression, enabling photothermal-induced immunogenic cell death (ICD). Chiral peptides synergize with Mn<sup>2+</sup>-mediated cGAS-STING activation and ICD, enhancing DC maturation and T cell infiltration (4.36- and 2.88-fold), suppressing tumor metastasis while establishing immune memory. Such chiral cyclic peptides offer a novel strategy for immune activation by regulating peptide chirality.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102931"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electronic cloud-regulation strategy enabling rapid and sensitive near-infrared detection of ONOO⁻ for dynamic monitoring of ferroptosis-mediated drug-induced liver injury 电子云调节策略，实现ONOO的快速和灵敏的近红外检测，用于动态监测铁中毒介导的药物性肝损伤

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-09-12 DOI: 10.1016/j.nantod.2025.102900

Yongchuang Li , Haiyue Liu , Yuru Liu , Shaowei Wang , Caixia Yin , Fangjun Huo

{"title":"Electronic cloud-regulation strategy enabling rapid and sensitive near-infrared detection of ONOO⁻ for dynamic monitoring of ferroptosis-mediated drug-induced liver injury","authors":"Yongchuang Li , Haiyue Liu , Yuru Liu , Shaowei Wang , Caixia Yin , Fangjun Huo","doi":"10.1016/j.nantod.2025.102900","DOIUrl":"10.1016/j.nantod.2025.102900","url":null,"abstract":"<div><div>Drug-induced liver injury (DILI) is caused by hepatotoxic effects resulting from drug metabolism. Extensive studies have demonstrated a close association between DILI progression and ferroptosis, a process characterized by redox imbalance triggered by lipid peroxidation. As a key product of redox imbalance and a critical biomarker of DILI, peroxynitrite (ONOO<sup>-</sup>) plays a pivotal regulatory role in ferroptosis. To elucidate the precise mechanism of ONOO<sup>-</sup> in ferroptosis-mediated DILI, there is an urgent need for ONOO<sup>-</sup> fluorescent probes with high specificity, sensitivity and signal-to-noise ratio. This study innovatively modified the traditional pyridine hemicyanine fluorophore into a quinoline hemicyanine structure, achieving a red-shifted fluorescence emission wavelength through extended conjugation and enhanced electron delocalization. Systematic site screening identified diphenyl phosphate ester as the optimal reaction site, demonstrating exceptional specificity, sensitivity and 75 s response characteristics. By conjugating the optimized fluorophore with the reaction site via nucleophilic substitution, we successfully developed a novel ratiometric fluorescent probe, <strong>zt-4</strong>. Given the remarkable similarities in pathological mechanisms (including signaling pathways, regulatory nodes, and biomarkers) between osteoarthritis (OA) and DILI, we first validated the imaging performance of <strong>zt-4</strong> in a complex inflammatory OA Model. Subsequently, we applied probe <strong>zt-4</strong> to analyze ferroptosis-mediated DILI model at both cellular and murine levels. For the first time, our study revealed that the ferroptosis pathway dynamically regulates ONOO<sup>-</sup> levels in DILI, elucidating its molecular mechanism. These findings provide new theoretical foundations and intervention strategies for DILI treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102900"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ROS/NO dual-releasing organic polymer nanoenzymes for NIR-II photo-adjuvant cancer immunotherapy ROS/NO双释放有机聚合物纳米酶用于NIR-II光辅助癌症免疫治疗

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-11-25 DOI: 10.1016/j.nantod.2025.102936

Jiayao Ding , Long Wang , Fengshuo Wang , Yue Liu , Haidong Chen , Jingchao Li , Ting Su

{"title":"ROS/NO dual-releasing organic polymer nanoenzymes for NIR-II photo-adjuvant cancer immunotherapy","authors":"Jiayao Ding , Long Wang , Fengshuo Wang , Yue Liu , Haidong Chen , Jingchao Li , Ting Su","doi":"10.1016/j.nantod.2025.102936","DOIUrl":"10.1016/j.nantod.2025.102936","url":null,"abstract":"<div><div>Nitric oxide (NO) and reactive oxygen species (ROS) are crucial signal molecules in living systems, providing alternative strategies for cancer treatment other than chemotherapy drug. Nevertheless, the uncontrollable ROS/NO induction will lead to low therapeutic results and potential off-target effects. In this paper, ROS/NO dual-releasing organic polymeric nanoenzymes (O<sub>2</sub><sup>·-</sup>/NO-SPN) are designed, capable of synergistically elevating ROS and NO levels in tumors upon second near-infrared (NIR-II) photo-triggered activation, thus establishing a photoactivated adjuvant strategy for enhanced cancer immunotherapy. A newly synthesized semiconducting polymer (L7) with an outstanding NIR-II photothermal performance is utilized as the core for fabricating such nanoenzymes. Using a film-dispersion technique coupled with hydration, a NO donor S-nitrosoglutathione (GSNO), superoxide anions (O<sub>2</sub><sup>·-</sup>) donor 3-indoleacetic acid (3IAA) and L7 are co-loaded in a thermal-responsive nano-liposome, followed by surface embellishment of horseradish peroxidase (HRP). The formed O<sub>2</sub><sup>·-</sup>/NO-SPN can generate local heat <em>via</em> NIR-II photothermal effect, and thus the thermal-responsive nano-liposomes are collapsed to release 3IAA, which is then catalyzed by HRP to produce O<sub>2</sub><sup>·-</sup>, triggering tumor cell death in a NIR-II photodynamic-like manner. Moreover, the local heating effect results in production of NO by GSNO to further kill tumor cells and also activate the systemic immune responses through inducing immunogenic cell death and macrophage polarization. This ROS/NO dual-releasing strategy is demonstrated to effectively inhibit bilateral tumor growths and metastasis. The current study thereby offers a promising tool to regulate both ROS and NO levels concurrently in biological systems.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102936"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145584253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced strategies for extending the blood circulation time of nano-based delivery systems 延长纳米给药系统血液循环时间的先进策略

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2026-01-18 DOI: 10.1016/j.nantod.2026.102978

Mohammad Reza Kandi , Amir Zarebkohan , Donya Shaterabadi , Roya Salehi , Babak Negahdari , Michael R. Hamblin

{"title":"Advanced strategies for extending the blood circulation time of nano-based delivery systems","authors":"Mohammad Reza Kandi , Amir Zarebkohan , Donya Shaterabadi , Roya Salehi , Babak Negahdari , Michael R. Hamblin","doi":"10.1016/j.nantod.2026.102978","DOIUrl":"10.1016/j.nantod.2026.102978","url":null,"abstract":"<div><div>The rapid clearance of nano‑based delivery systems has motivated the search for strategies to extend the blood circulation time. This review moves beyond traditional strategies used for the design of extended blood‑circulation nanomaterials, and examines some recent advances in two complementary domains: physicochemical optimization and biological modulation. This review highlights trends in chemical and topological modifications regarding PEGylation, and shows that the transition to alternative polymers is accompanied by a set of challenges and advantages. It also examines various types of transformable nanoparticles and highlights the dangers inherent in stimulus heterogeneity and the complexity of their manufacturing process. The innovations and challenges of protein‑corona engineering are likewise evaluated. Furthermore, the modulation of complement and macrophage pathways as major immunological barriers promoting rapid NP clearance is discussed, and new approaches such as complement inhibitors and mononuclear phagocyte system blockade are explored. In addition, hitchhiking and biomimetic systems are discussed as emerging strategies to enhance blood circulation. Finally, we discuss the transition from static systems to dynamic, biointeractive, targeted and controllable platforms for achieving prolonged blood circulation.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102978"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inside Back Cover - Graphical abstract TOC/TOC in double column continued from OBC if required, otherwise blank page 封底内-图解摘要TOC/TOC双栏，如果需要，从OBC继续，否则空白页

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/S1748-0132(26)00019-8

引用次数: 0

Outside Back Cover - Graphical abstract TOC/TOC in double column/Cover image legend if applicable, Bar code, Abstracting and Indexing information 封底外-图形摘要TOC/双栏TOC/封面图例（如适用），条形码，摘要和索引信息

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/S1748-0132(26)00020-4

引用次数: 0

Biomimetic nanomaterial-based strategies for spinal cord injury repair 基于仿生纳米材料的脊髓损伤修复策略

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2026-01-10 DOI: 10.1016/j.nantod.2025.102969

Rui-Lian Chen , Lu Jiang , Hai-Bo Teng , Jin-Long Yang , Wen-Bo He , Yang Zhang , Qing-qing Ren , Hong-Xu Chen , Rang-rang Fan , Jian-Guo Xu

{"title":"Biomimetic nanomaterial-based strategies for spinal cord injury repair","authors":"Rui-Lian Chen , Lu Jiang , Hai-Bo Teng , Jin-Long Yang , Wen-Bo He , Yang Zhang , Qing-qing Ren , Hong-Xu Chen , Rang-rang Fan , Jian-Guo Xu","doi":"10.1016/j.nantod.2025.102969","DOIUrl":"10.1016/j.nantod.2025.102969","url":null,"abstract":"<div><div>Spinal cord injury (SCI) poses significant clinical challenges marked by profound functional impairments and limited clinical interventions due to its complex pathological microenvironment and limited intrinsic regenerative capacity. This review systematically explores the pathophysiology of SCI, emphasizing key therapeutic targets in neuroprotection, axon regeneration, and immunomodulation. We innovatively propose a functional classification framework to categorize synthetic nanomaterials into (1) targeted drug delivery systems, (2) nanoparticle-hydrogel hybrid systems and (3) stimuli-responsive functional nanoparticles, effectively resolving overlaps in traditional classifications. Furthermore, biogenic nanomaterials—including exosomes, cell membrane-coated systems, and decellularized extracellular matrix (ECM) scaffolds—are highlighted for their innate biocompatibility, immune evasion, and bioactivity. These biogenic nanomaterials synergize with advanced technologies such as genetic engineering and combinatorial therapies to enhance neural repair. Particularly, we provide the first systematic comparison of microstructural differences in decellularized scaffolds derived from diverse tissues (e.g., spinal cord, optic nerve, sciatic nerve) and their mechanisms in guiding axonal regeneration. Despite promising preclinical outcomes, challenges such as standardization, scalable production and long-term biosafety remain in the gap between experimental models and clinical applications. Future directions focus on dynamic responsiveness, multifunctional combinatorial designs and integration with regenerative medicine paradigms to achieve functional recovery in SCI management.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102969"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Redox-driven mechanoregulation of invasive TNBC cells using poly(tannic acid) nanospheres” [Nano Today, 66 (2026), 102907] “使用聚单宁酸纳米球对侵袭性TNBC细胞的氧化还原驱动的机械调节”的勘误表[Nano Today， 66 (2026), 102907]

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-10-18 DOI: 10.1016/j.nantod.2025.102917

Minhee Ku , Suhui Jeong , Nara Yoon , Hwain Myeong , Jinwon Kwon , Jaemoon Yang , Sungbaek Seo

引用次数: 0