Nano Today最新文献_第8页

Hydrogel empowered extracellular vesicles isolation, detection, and delivery 水凝胶增强了细胞外囊泡的分离、检测和递送

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-28 DOI: 10.1016/j.nantod.2025.102817

Yuting Li , Zhinan Liu , Zelin Zheng , Liyi Bai , Wen Wang , Li Min , Honggang Hu , Yejiao Shi

{"title":"Hydrogel empowered extracellular vesicles isolation, detection, and delivery","authors":"Yuting Li , Zhinan Liu , Zelin Zheng , Liyi Bai , Wen Wang , Li Min , Honggang Hu , Yejiao Shi","doi":"10.1016/j.nantod.2025.102817","DOIUrl":"10.1016/j.nantod.2025.102817","url":null,"abstract":"<div><div>Extracellular vesicles (EVs), bilayered phospholipid structures capable of transporting diverse biomolecules from parent cells to neighboring cells or distant organs, exhibit remarkable potential in disease diagnosis and treatment. However, their efficient isolation, accurate detection, and controlled delivery have been greatly hindered by their low density in body fluid, low concentration of containing biomarkers, as well as rapid circulation rate <em>in vivo</em>, respectively. Over the past decade, an expanding number of studies have found that the three-dimensional porous hydrogels with adjustable structures, customizable functions, as well as desirable biocompatibility and biodegradability could provide a powerful platform for tackling these obstacles. Herein, this review summarized the recent progress in utilizing natural and synthetic hydrogels to assist in the isolation, detection, and delivery of EVs, with an emphasis on the relevant properties of hydrogels. In addition, the associated challenges were considered and the emerging possible opportunities were discussed. The comprehensive understanding of the hydrogel empowered isolation, detection, and delivery of EVs would promote the future development of EV-based integrating platforms for disease diagnosis and treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102817"},"PeriodicalIF":13.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A branched DNA nanoplatform-based mRNA vaccine for efficient immunotherapy in vivo 基于分支DNA纳米平台的mRNA疫苗在体内的有效免疫治疗

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-27 DOI: 10.1016/j.nantod.2025.102818

Changping Yang , Jing Fan , Hanyin Zhu , Huarui Liu , Xintong Li , Dandan Li , Hong Wang , Jianbing Liu , Baoquan Ding

{"title":"A branched DNA nanoplatform-based mRNA vaccine for efficient immunotherapy in vivo","authors":"Changping Yang , Jing Fan , Hanyin Zhu , Huarui Liu , Xintong Li , Dandan Li , Hong Wang , Jianbing Liu , Baoquan Ding","doi":"10.1016/j.nantod.2025.102818","DOIUrl":"10.1016/j.nantod.2025.102818","url":null,"abstract":"<div><div>Immunotherapy based on mRNA vaccine has been widely developed for treatments of various diseases. Herein, we report a branched DNA nanoplatform-based mRNA vaccine for efficient immunotherapy <em>in vivo</em>. In our design, two branched DNA structures are employed as the connectors to co-assemble with disulfide bonds-involved RNA linker. In this branched DNA nanoplatform, the mRNA with 5’ cap and 3’ poly A can be efficiently loaded by RNA hybridization. Meanwhile, the adjuvants (CpG) and lipids (DOPE) can be site-specifically included through DNA hybridization. After co-assembly, the nanoparticle with lipid seeds on the surface can function as a template for lipid growth. The mRNA-loaded and lipids-coated DNA nanoparticle can achieve an efficient cellular uptake and subsequent stimuli-responsive drug release for successful protein expression. Finally, the tumor antigen-encoded mRNA vaccine can elicit a pronounced immunotherapy for tumor inhibition <em>in vivo</em>. This rationally developed branched DNA nanoplatform-based mRNA vaccine presents a new avenue for the development of immunotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102818"},"PeriodicalIF":13.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic metal-phenolic network-coated elastin-like polypeptide micelles as an immunogenic cell death inducer for orthotopic glioma sonodynamic-chemodynamic-immune therapy 仿生金属-酚醛网络包覆弹性蛋白样多肽胶束作为原位胶质瘤声动力学-化学动力学-免疫治疗的免疫原性细胞死亡诱导剂

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-27 DOI: 10.1016/j.nantod.2025.102810

Zhiqiang Wang , Yunqi Guo , Gaoming Li , Honghua Guo , Yanying Li , Jinxia Wang , Kangan Li , Serge Mignani , Mingwu Shen , Elisabeth Garanger , Sébastien Lecommandoux , Xiangyang Shi

{"title":"Biomimetic metal-phenolic network-coated elastin-like polypeptide micelles as an immunogenic cell death inducer for orthotopic glioma sonodynamic-chemodynamic-immune therapy","authors":"Zhiqiang Wang , Yunqi Guo , Gaoming Li , Honghua Guo , Yanying Li , Jinxia Wang , Kangan Li , Serge Mignani , Mingwu Shen , Elisabeth Garanger , Sébastien Lecommandoux , Xiangyang Shi","doi":"10.1016/j.nantod.2025.102810","DOIUrl":"10.1016/j.nantod.2025.102810","url":null,"abstract":"<div><div>Development of a theranostic nanomedicine to tackle orthotopic glioma remains to be challenging due to the difficulties of blood-brain barrier crossing and integration of different theranostic modalities. Herein, we report the design of biomimetic macrophage membrane (MM)-camouflaged metal-phenolic network (MPN)-coated micelles formed by amphiphilic elastin-like polypeptide (ELP)-chlorin e6 (Ce6) conjugates. We show that the MPN formed by assembly of Mn(II) and tannic acid (for short, TM) enables stable coating of the micelles, and the prepared Ce6-ELP@TM/MM exhibits good water dispersibility with a mean size of 67.8 nm. Under the tumor microenvironment condition, the Ce6-ELP@TM/MM could fast release Mn<sup>2 +</sup> to generate reactive oxygen species (ROS) and facilitate Ce6 (a sonosensitizer) to generate singlet oxygen upon ultrasound irradiation, thereby killing cancer cells to induce immunogenic cell death (ICD) through chemodynamic/sonodynamic therapy. Moreover, the ROS-caused DNA damage could combine with Mn<sup>2+</sup> to activate the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway of cancer cells, thus synergizing ICD to trigger enhanced antitumor immune responses to tackle an orthotopic mouse glioma model thanks to the MM-rendered BBB crossing and Mn<sup>2+</sup>-facilitated magnetic resonance imaging. The developed Ce6-ELP@TM/MM could be used as an ICD inducer to facilitate sonodynamic/chemodynamic/immune therapy of glioma or other tumor types.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102810"},"PeriodicalIF":13.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144137757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering hydroxyapatite nanocrystals for cancer nanomedicine through ion substitution: Advances and prospects 离子取代工程羟基磷灰石纳米晶体用于肿瘤纳米药物：进展与展望

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-27 DOI: 10.1016/j.nantod.2025.102816

Gerardo Martin Quindoza III , Takuma Watanabe , Hayato Laurence Mizuno , Vincent Irawan , Yasutaka Anraku , Toshiyuki Ikoma

{"title":"Engineering hydroxyapatite nanocrystals for cancer nanomedicine through ion substitution: Advances and prospects","authors":"Gerardo Martin Quindoza III , Takuma Watanabe , Hayato Laurence Mizuno , Vincent Irawan , Yasutaka Anraku , Toshiyuki Ikoma","doi":"10.1016/j.nantod.2025.102816","DOIUrl":"10.1016/j.nantod.2025.102816","url":null,"abstract":"<div><div>Cancer nanomedicine bridges cancer biology and nanotechnology to enhance diagnostic accuracy and therapeutic efficacy across various cancer modalities, ultimately aiming to improve patient outcomes and survival. Numerous nanomaterials have been explored for cancer nanomedicine; however, most suffer from systemic toxicity and severe side effects. Recently, hydroxyapatite (HAp), the primary inorganic component of bones and teeth, has emerged as a promising nanoplatform for cancer diagnosis and treatment, owing to its inherent biocompatibility and excellent biodistribution. Moreover, its capacity for ion substitutions has further expanded its potential, enhancing their existing properties and introducing new functionalities that are beneficial for cancer nanomedicine. With the growing interest in ionic substituted HAp nanocrystals, summarizing significant findings and mapping out the field’s current progress is imperative. This review examines recent literature on their applications in cancer diagnostics and therapeutics, as well as in theranostics. Key advancements were identified and outlined, and insights into prospective opportunities to guide future research were explored. This review highlights the immense potential of ionic substituted HAp nanosystems as a versatile and promising platform, paving the way for the development of safer and more effective nanomedicine strategies.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102816"},"PeriodicalIF":13.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing intranasally administered electro-responsive nanodrugs for rapid epilepsy treatment 开发鼻内给药的电反应纳米药物用于快速治疗癫痫

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-26 DOI: 10.1016/j.nantod.2025.102808

Wei Shu , Yue Jiang , Shijin Li , Jian Li , Xueting Pan , Changyong Wang , Hai Wang , Tao Yu

{"title":"Developing intranasally administered electro-responsive nanodrugs for rapid epilepsy treatment","authors":"Wei Shu , Yue Jiang , Shijin Li , Jian Li , Xueting Pan , Changyong Wang , Hai Wang , Tao Yu","doi":"10.1016/j.nantod.2025.102808","DOIUrl":"10.1016/j.nantod.2025.102808","url":null,"abstract":"<div><div>Epilepsy is a prevalent neurological disorder, with antiepileptic drugs serving as the cornerstone of clinical treatment. However, oral antiepileptic drugs are limited by issues such as low absorption rates, poor bioavailability, and significant toxic side effects. Although nanodrug delivery systems have shown considerable promise in improving drug efficacy and minimizing side effects, they are hindered by biological barriers, particularly the blood-brain barrier (BBB). Intranasal administration of nanodrugs presents a distinct advantage, as it can bypass the BBB and deliver drugs directly to the brain with rapid absorption, making it especially suitable for the treatment of acute epilepsy and status epilepticus. In response to this need, we have designed and synthesized an electrically responsive nanodrug for intranasal delivery that releases the antiepileptic drug in response to abnormal electrical activity during seizures. By capitalizing on the fast brain-targeting capability of intranasal administration, these nanoparticles quickly penetrate the brain and react to the irregular electrical currents generated by seizures, facilitating rapid drug release. This innovative approach provides a timely and effective means of alleviating acute epilepsy and status epilepticus, offering a rapid, targeted strategy for delivering antiepileptic drugs.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102808"},"PeriodicalIF":13.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144137758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Au&WO3 heterojunctions against multidrug-resistant bacteria 抗多重耐药细菌的Au&WO3异质结

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-24 DOI: 10.1016/j.nantod.2025.102813

Pai Zhang , Ruitao Cha , Yanxue Si , Huize Luo , Qianqian Lin , Jiamin Qin , Hao Tang , Fengshan Zhou , Xiaohui Wang , Peng Jiang , Xingyu Jiang

{"title":"Au&WO3 heterojunctions against multidrug-resistant bacteria","authors":"Pai Zhang , Ruitao Cha , Yanxue Si , Huize Luo , Qianqian Lin , Jiamin Qin , Hao Tang , Fengshan Zhou , Xiaohui Wang , Peng Jiang , Xingyu Jiang","doi":"10.1016/j.nantod.2025.102813","DOIUrl":"10.1016/j.nantod.2025.102813","url":null,"abstract":"<div><div>Wound infections caused by multidrug-resistant (MDR) Gram-negative bacteria remain a significant medical challenge. Existing treatments, including antibiotics, antimicrobial peptides, and nanomaterials, are limited by drug resistance and toxicity. It is urgent to develop an effective alternative agent for treatment of infected wound. Here, we synthesized Au&WO<sub>3</sub> heterojunctions <em>via</em> a hydrothermal method and NaBH<sub>4</sub> reduction to address MDR bacterial infections. We characterized the structure of Au&WO<sub>3</sub> heterojunctions by TEM, EDS, and zeta potential. Mechanistically, The enhanced bacterial activity could arise from synergistic effects of membrane disruption by Au nanoparticles and replacement of the molybdenum factor by W<sup>6 +</sup> ions. The Au<sub>1</sub>&WO<sub>3</sub> heterojunction had a minimum inhibitory concentration (MIC) of 12 µg/mL against MDR <em>E. coli</em>, outperforming individual Au nanoparticles and WO<sub>3</sub> nanorods. <em>In vitro</em>, Au<sub>1</sub>&WO<sub>3</sub> induced M2 macrophage polarization, demonstrating strong anti-inflammatory activity. The PG-Au<sub>1</sub>&WO<sub>3</sub> membranes exerted excellent antibacterial and anti-inflammation properties with good biocompatibility, promoting wound healing in MDR <em>E. coli</em>-infected wound models. The Au&WO<sub>3</sub> heterojunctions highlight their potential as a promising wound dressing for MDR infection treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102813"},"PeriodicalIF":13.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidized cholesterol-doped biomimetic pulmonary surfactant nanocarriers for enhanced pulmonary vaccine delivery 氧化胆固醇掺杂仿生肺表面活性剂纳米载体增强肺部疫苗递送

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-23 DOI: 10.1016/j.nantod.2025.102814

Meng-Qian Zhang , Hui-Ping Wen , Yi-Fan Wang , Ai-Xin Ma , Jin-Wei Bu , Yang-Yang Liu , Shu-Lin Liu , Zhi-Gang Wang

{"title":"Oxidized cholesterol-doped biomimetic pulmonary surfactant nanocarriers for enhanced pulmonary vaccine delivery","authors":"Meng-Qian Zhang , Hui-Ping Wen , Yi-Fan Wang , Ai-Xin Ma , Jin-Wei Bu , Yang-Yang Liu , Shu-Lin Liu , Zhi-Gang Wang","doi":"10.1016/j.nantod.2025.102814","DOIUrl":"10.1016/j.nantod.2025.102814","url":null,"abstract":"<div><div>Pulmonary vaccines are considered to have the potential to trigger the respiratory immune system, closely mimicking the natural entry process of pathogens and providing strong viral protection. To improve the immunogenicity of pulmonary vaccines, we introduced a potent delivery system: bioinspired pulmonary surfactant nanocarriers (BPSNs) doped with oxidized cholesterol, specifically 7-ketocholesterol (7-KC). Our study revealed that these nanocarriers, leveraging natural lung surfactant lipids, precisely target lung macrophages with superb biocompatibility. The delivery of a broad-spectrum influenza HA antigen (HA@BPSN) and a ZBP1-activating adjuvant (CBL0137) (CBL@BPSN) <em>via</em> BPSNs, effectively elicited potent immune responses without impairing surfactant functions. Compared to clinically validated traditional inactivated vaccines and the MF59 adjuvant, HA@BPSN and CBL@BPSN induced nearly a 10-fold increase in antibody titers and significantly enhanced CD4<sup>+</sup> and CD8<sup>+</sup> T cell responses. This nanovaccine approach showcases superior, broad-spectrum immunoprotection against diverse influenza strains, underscoring BPSN's potential as an effective respiratory vaccine delivery platform and paving the way for refined vaccine design and personalized treatments.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102814"},"PeriodicalIF":13.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes-incorporated biomaterials boost cancer immunotherapy 外泌体结合生物材料促进癌症免疫治疗

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-23 DOI: 10.1016/j.nantod.2025.102805

Yuechong Li , Jiazhen Yang , Songjie Shen , Jianxun Ding

{"title":"Exosomes-incorporated biomaterials boost cancer immunotherapy","authors":"Yuechong Li , Jiazhen Yang , Songjie Shen , Jianxun Ding","doi":"10.1016/j.nantod.2025.102805","DOIUrl":"10.1016/j.nantod.2025.102805","url":null,"abstract":"<div><div>Cancer immunotherapy has achieved significant advancements, generating substantial and sustained anti-cancer responses. However, emerging approaches, such as immune checkpoint blockade, chimeric antigen receptor-T cell therapy, and tumor vaccines, have shown limited efficacy against solid tumors. A significant challenge is immune evasion, in which tumor cells trigger insufficient immune responses and create immunosuppressive microenvironments. Exosomes-incorporated biomaterials combine the benefits of both biomaterials and exosomes, overcoming their limitations. These platforms are enriched with tumor-specific antigens, possess targeted delivery capabilities, and exhibit high permeability across biological barriers. As a result, they stimulate robust immune responses against tumors and reverse immunosuppressive microenvironments, providing a promising strategy for cancer immunotherapy. This review covers the preparation methods for exosomes-incorporated biomaterials and highlights their roles in various immune processes, including inducing immunogenic cell death of tumor cells, enhancing antigen presentation, regulating effector T cell responses, and inhibiting immunosuppressive cells, such as regulatory T cells, tumor-associated macrophages, and myeloid-derived suppressor cells. These versatile nanoplatforms have the potential to enhance cancer immunotherapy and show promise for clinical application, though challenges remain for their clinical translation.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102805"},"PeriodicalIF":13.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel hypocrellin B derivative for photodynamic therapy-driven cancer immunotherapy via triggering immunogenic cell death 一种新型的下丘脑素B衍生物，通过触发免疫原性细胞死亡，用于光动力治疗驱动的癌症免疫治疗

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-22 DOI: 10.1016/j.nantod.2025.102809

Jixing Cheng , Jinxia Li , Jiasheng Wu , Weiyan Kang , Kaijie Feng , Yue You , Chuqi Wan , Yiting Zheng , Liang Yan , Ru Liu , Feng Zhao , Yunhui Li

{"title":"A novel hypocrellin B derivative for photodynamic therapy-driven cancer immunotherapy via triggering immunogenic cell death","authors":"Jixing Cheng , Jinxia Li , Jiasheng Wu , Weiyan Kang , Kaijie Feng , Yue You , Chuqi Wan , Yiting Zheng , Liang Yan , Ru Liu , Feng Zhao , Yunhui Li","doi":"10.1016/j.nantod.2025.102809","DOIUrl":"10.1016/j.nantod.2025.102809","url":null,"abstract":"<div><div>The natural photosensitizer hypocrellin B (HB) exhibits restricted absorption within the 650–900 nm therapeutic window thereby impeding its clinical translation. This work synthesizes chemical derivative (HB1) from HB to address its restricted therapeutic-window absorption. Upon 660 nm laser irradiation, HB1 localizes to lysosomes, inducing membrane permeabilization and immunogenic cell death (ICD) while concurrently enhancing dendritic cell (DC) maturation and phagocytosis in vitro through photodynamic therapy (PDT). By further co-encapsulating HB1 and the immunoadjuvant R837 in Poly(lactic-co-glycolic acid) (PLGA) nanoparticles, HB1 induces ICD to release tumor antigens that synergize with R837-mediated immune stimulation, achieving potent antitumor effects via enhanced CD8⁺/CD4⁺ T cell infiltration and DC activation. Furthermore, prophylactic administration of PDT-generated tumor lysates combined with R837 primes antitumor immunity and delays tumor progression. These results substantiate the clinical potential of HB1 for photodynamic immunotherapy and suggest a promising strategy for developing personalized PDT vaccines against tumor recurrence. The approach leverages surgically resected tumor tissues to prepare tumor-specific vaccines, providing insights for clinical translation in cancer immunotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102809"},"PeriodicalIF":13.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PM@DCm nanohybrid-mediated pleiotropic antigen presentation for enhanced melanoma immunotherapy PM@DCm纳米杂交介导的多效抗原提呈增强黑色素瘤免疫治疗

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-20 DOI: 10.1016/j.nantod.2025.102811

Zhongsheng Xu , Xiaojing He , Ranran Luo , Chenxi Zhang , Zening Zhang , Pengchen Ren , Jingjing Zhang , Xiaoyuan Chen , Yun Liu

{"title":"PM@DCm nanohybrid-mediated pleiotropic antigen presentation for enhanced melanoma immunotherapy","authors":"Zhongsheng Xu , Xiaojing He , Ranran Luo , Chenxi Zhang , Zening Zhang , Pengchen Ren , Jingjing Zhang , Xiaoyuan Chen , Yun Liu","doi":"10.1016/j.nantod.2025.102811","DOIUrl":"10.1016/j.nantod.2025.102811","url":null,"abstract":"<div><div>Melanoma, an aggressive cancer with poor prognosis, benefits only minimally from the current immunotherapies. To address these therapeutic shortcomings, achieving efficient antigen presentation is pivotal for robust tumor-specific T-cell activation and durable antitumor immunity. Here, a multifunctional nanohybrid (denoted as PM@DCm) with activated DC membrane-coated, platinum-embedded, hollow manganese-based nanohybrid is developed, which can effectively proceed antigens presentation. The core of multispiked platinum-manganese oxide (termed as Pt@MnO<sub>2</sub>) functions dually as a Stimulator of Interferon Genes (STING) agonist and an inducer of immunogenic cell death (ICD) in response to the tumor microenvironment, triggering inflammatory cytokine and actionable tumor antigens release. These events facilitate <em>in-situ</em> DC maturation, improving antigen uptake and presentation to T cells. Simultaneously, the DC-mimetic structure of PM@DCm retains critical costimulatory markers, MHC class I antigen complexes, and chemokine receptors, effectively simulating the functionality of mature DCs. This dual mechanism ensures robust pleiotropic antigen cross-presentation and cytotoxic T-cell priming. As a result, this PM@DCm nanohybrid significantly suppresses tumor growth and metastasis, elicits robust antitumor immunity, and shows strong prophylactic potential. This novel strategy leverages the synergy between mimicking mature DCs and promoting <em>in-stiu</em> DC maturation, delivering pleiotropic antigen presentation for enhanced melanoma immunotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102811"},"PeriodicalIF":13.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0