Nano Today最新文献_第8页

Self-assembled peptide nanofibrous hydrogel based multifunctional platform for rapid reprogramming and in situ monitoring of tumor cells into cancer stem cells 基于自组装肽纳米纤维水凝胶的多功能平台快速重编程和原位监测肿瘤细胞转化为癌症干细胞

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-10-25 DOI: 10.1016/j.nantod.2025.102921

Xue Wei , Mingxuan Hao , Hanzhi Xiong , Zufa Sabeel , Wenjing Zhang , Yan Liu , Yunfan Zhou , Zhao Yang , Xu Chen , Wensheng Yang

{"title":"Self-assembled peptide nanofibrous hydrogel based multifunctional platform for rapid reprogramming and in situ monitoring of tumor cells into cancer stem cells","authors":"Xue Wei , Mingxuan Hao , Hanzhi Xiong , Zufa Sabeel , Wenjing Zhang , Yan Liu , Yunfan Zhou , Zhao Yang , Xu Chen , Wensheng Yang","doi":"10.1016/j.nantod.2025.102921","DOIUrl":"10.1016/j.nantod.2025.102921","url":null,"abstract":"<div><div>Cancer stem cells (CSCs), inherently resistant to chemotherapy and radiotherapy, are key drivers of tumor recurrence and metastasis. Conventional <em>in vitro</em> CSC enrichment models relying on tumor isolation and sphere-formation are often time-consuming and inefficient. Meanwhile, the separation and characterization of CSC face challenges. Here, a self-assembled peptide nanofibrous hydrogel-based multifunctional platform composed of N-fluorenylmethoxycarbonyl diphenylalanine (Fmoc-FF) serves as a functional 3D matrix for efficient CSC enrichment and direct in-situ electrochemical monitoring. Flow cytometric analysis demonstrated that the Fmoc-FF hydrogel robustly induced CSC-like phenotypes across breast, cervical, and lung tumor cells (TCs) under mild stiffness conditions (∼10 kPa), significantly lower than the stiffness used in most previously reported matrices. Notably, TCs 3D cultured in the nanofibrous hydrogel led to a two-order-of-magnitude proliferation increase within 5 days. This is attributed to the in situ self-assembly of Fmoc-FF monomers in the presence of cells, generating a dense nanofiber network that tightly encapsulates cells and enhances cell-matrix interactions, even at low seeding density. Furthermore, electrochemical sensors based on the Fmoc-FF hydrogel allow in situ, non-destructive monitoring of dynamic changes in stemness-associated biomarker aldehyde dehydrogenase 1 during TC reprogramming. This approach avoids cell isolation and preserves critical biological information, providing a powerful tool for stemness evaluation. Overall, this study demonstrates the robust stemness-inducing capability and in situ cell monitoring of the self-assembled peptide hydrogel integrated platform for the first time, presenting a promising strategy to enhance <em>in vitro</em> CSC reprogramming efficiency and yield.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102921"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145358483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of early diagnostic strategies by targeting CXCR3 following heart transplantation 心脏移植后CXCR3靶向早期诊断策略的发展

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-12-29 DOI: 10.1016/j.nantod.2025.102966

Yuan Chang , Peiyuan Li , Zhe Sun , Weiteng Wang , Xiao Chen , Xiumeng Hua , Yixuan Sheng , Ningning Zhang , Qian Zhao , Kai Xing , Xingchao Du , Mengda Xu , Jiangping Song

{"title":"Development of early diagnostic strategies by targeting CXCR3 following heart transplantation","authors":"Yuan Chang , Peiyuan Li , Zhe Sun , Weiteng Wang , Xiao Chen , Xiumeng Hua , Yixuan Sheng , Ningning Zhang , Qian Zhao , Kai Xing , Xingchao Du , Mengda Xu , Jiangping Song","doi":"10.1016/j.nantod.2025.102966","DOIUrl":"10.1016/j.nantod.2025.102966","url":null,"abstract":"<div><div>Early diagnosis and treatment of acute rejection are crucial for prolonging graft survival in heart transplantation, yet no highly effective method exists for its timely detection. In this study, we identified CXCR3 as a T cell-specific biomarker via single-cell RNA sequencing of cardiac allografts and developed a nanoparticle-based fluorescent probe (CXCR3-NP) targeting CXCR3 to evaluate its diagnostic efficacy using in vivo imaging. Results demonstrated upregulated CXCR3 expression in T cells within acutely rejected tissues, validated in murine models and clinical samples, and the probe effectively bound to CXCR3 + T cells with fluorescence intensity increasing progressively during rejection. Furthermore, CXCR3-blocking antibody treatment alleviated acute rejection and reduced CXCR3 + T cell infiltration, leading to a significant decrease in CXCR3-NP fluorescence in grafts, thereby confirming the probe's high sensitivity in detecting diminished immune cell activity. This study developed a CXCR3-specific fluorescent probe for diagnosing acute rejection, with its sensitivity validated in a murine heart transplantation model showing alleviated acute rejection. Our findings provide novel insights into diagnostic strategies for cardiac allograft rejection.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102966"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultra large ion substitute resists Jahn-Teller effects towards high-performance Mn-based P2-Na0.67Ni0.33Mn0.67O2 cathode 超大离子替代物抗jann - teller效应制备高性能mn基P2-Na0.67Ni0.33Mn0.67O2阴极

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-11-10 DOI: 10.1016/j.nantod.2025.102925

Xiang Ding , Caijiang Jiang , Piluan Li , Yong Fan , Zhibin Cheng , Haonan Li , Liangwei Liu , Yi Xiao , Fang Chen , Lili Han

{"title":"Ultra large ion substitute resists Jahn-Teller effects towards high-performance Mn-based P2-Na0.67Ni0.33Mn0.67O2 cathode","authors":"Xiang Ding , Caijiang Jiang , Piluan Li , Yong Fan , Zhibin Cheng , Haonan Li , Liangwei Liu , Yi Xiao , Fang Chen , Lili Han","doi":"10.1016/j.nantod.2025.102925","DOIUrl":"10.1016/j.nantod.2025.102925","url":null,"abstract":"<div><div>P2-Na<sub>0.67</sub>Ni<sub>0.33</sub>Mn<sub>0.67</sub>O<sub>2</sub> (NNMO) Mn-based cathode has high discharge voltage/capacity and facile manufacture in sodium-ion batteries (SIBs). Meanwhile, it faces fatal irreversible P2→O2 transition at elevated 4 V and grain cracking during cycles. Herein, Ba<sup>2+</sup> with a super large ionic radius of 135 pm is incorporated into the Ni<sup>2+</sup> (0.69 Å) and Mn<sup>4+</sup> (0.53 Å) lattice sites to regulate the MnO6 octahedrons in crystallographic structure. This strategy effectively increases the interlayer spacing from 0.5574 nm to 0.5667 nm and suppresses the Jahn-Teller effects of Mn<sup>3+</sup> via charge compensation as well as P2→O2 phase transition. These gain effects are fundamentally elucidated by a series of in-situ (i.e. in-situ XRD and in-situ DRT) and ex-situ (e.g. XPS spectra, HRTEM images) characterizations. Theoretical calculations further clarify the reduced diffusion energy barrier and enhanced bulk conductivity and differential charge. The optimized Ba-doped NNMO shows extremely advantageous cycling performance in 1 C (118 mA h g<sup>−1</sup>@91 % @500 cycles), 5 C (90.8 mA h g<sup>−1</sup>@73.1 %@2000 cycles), and 10 C (80.9 mA h g<sup>−1</sup>@68.4 %@2000 cycles) current densities. It also has superior rate capability (80.9 mA h g<sup>−1</sup>@10 C) and negligible voltage decay of 1 ‰ per cycle. The full-cells assembled with hard carbon display competitive cycle performance (107 mA h g<sup>−1</sup>@87.1 %@0.1 C@500 cycles) and energy density (261 W h kg<sup>−1</sup>), demonstrating enormously scientific significance and practical value for high-performance SIBs.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102925"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered protein corona by Bispecific Antibody endows liposome with enhanced tumor targeting ability and mitigated accelerated blood clearance effect 双特异性抗体工程蛋白冠增强了脂质体的肿瘤靶向能力，减轻了加速血液清除效应

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-11-04 DOI: 10.1016/j.nantod.2025.102923

Xiaoli Wei , Tianhao Ding , Meili Xi , Kristofer J. Thurecht , Christopher B. Howard , Jiwei Cui , Changyou Zhan , Zui Zhang

{"title":"Engineered protein corona by Bispecific Antibody endows liposome with enhanced tumor targeting ability and mitigated accelerated blood clearance effect","authors":"Xiaoli Wei , Tianhao Ding , Meili Xi , Kristofer J. Thurecht , Christopher B. Howard , Jiwei Cui , Changyou Zhan , Zui Zhang","doi":"10.1016/j.nantod.2025.102923","DOIUrl":"10.1016/j.nantod.2025.102923","url":null,"abstract":"<div><div>One of the major challenges in the development of active targeting nanomedicines is the plasma protein corona (PC), which might interfere with or diminish the targeting function. A novel strategy has emerged by precisely regulating the PC through the utilization of endogenous proteins, which is possible to transform the PC into an integral component that enhances targeting ability. However, the individual variability and fluctuating concentrations of endogenous proteins in plasma limit its practical application. In this study, we employed a bispecific antibody (BsAb) integrating mPEG-scFv (a single chain variable fragment to methoxy polyethylene glycol) and HER2-scFv (human epidermal growth factor receptor 2 scFv) to assembly with liposome. By pre-engineering the PC of liposomes, the targeting function to HER2<sup>+</sup> cells could be preserved during circulation. Notably, the PC formed by BsAb competitively inhibited the binding of endogenous anti-PEG antibodies, thereby reducing subsequent complement activation and alleviating the accelerated blood clearance (ABC) effect. In tumor-bearing mice, BsAb-sLip demonstrated significant accumulation in HER2<sup>+</sup> human ovarian cancer cells (SKOV3). In the presence of anti-PEG antibodies after liposome stimulation in mice, BsAb significantly mitigated the ABC effect with prolonged liposome circulation. Consistently, in human serum containing pre-existing anti-PEG antibodies, BsAb suppressed liposome-induced complement activation, inhibited macrophage phagocytosis, and maintained the targeting ability toward HER2<sup>+</sup> tumor cells. These findings indicated that the engineered PC strategy via BsAb represented an effective targeting approach improving the overall <em>in vivo</em> performance of nanomedicines.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102923"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145462487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Size dependent nephrotoxicity of polystyrene microplastics revealed by single-cell transcriptomics profiling 通过单细胞转录组学分析揭示聚苯乙烯微塑料的大小依赖性肾毒性

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-11-08 DOI: 10.1016/j.nantod.2025.102924

Chen Wang , Tong Yang , Xueling He , Cui Liu , Ang Ma , Chao Chen , Yunmeng Bai , Huiying Li , Peng Gao , Lirun Zhou , Da Chen , Jigang Wang , Huan Tang

{"title":"Size dependent nephrotoxicity of polystyrene microplastics revealed by single-cell transcriptomics profiling","authors":"Chen Wang , Tong Yang , Xueling He , Cui Liu , Ang Ma , Chao Chen , Yunmeng Bai , Huiying Li , Peng Gao , Lirun Zhou , Da Chen , Jigang Wang , Huan Tang","doi":"10.1016/j.nantod.2025.102924","DOIUrl":"10.1016/j.nantod.2025.102924","url":null,"abstract":"<div><div>Microplastics (MPs) are emerging environmental contaminants with growing concern over their potential nephrotoxicity. However, their size-dependent effects on kidney function remain poorly understood. Here, we employed single-cell RNA sequencing (scRNA-seq) to systematically investigate the renal cellular responses to polystyrene microplastics (PS-MPs) of different sizes (50 nm, 500 nm, and 5 μm). Our results revealed that proximal tubular (PT) cells and renal immune cells are the primary targets of PS-MPs, exhibiting distinct transcriptomic and functional alterations. Medium- and large-sized particles induced stronger inflammatory responses, oxidative stress, ATP depletion, and apoptosis compared to smaller ones. STAT1 was identified as a key regulator mediating size-dependent inflammation in PT cells, and its knockdown significantly attenuated PS-MPs-induced injury. Immune cells profiling further showed particle size-specific activation patterns, with macrophages and cytotoxic T cells displaying pronounced pro-inflammatory and cytotoxic responses. These findings highlight the importance of particle size in dictating microplastic toxicity and underscore the need for size-specific safety evaluations. This study provides novel mechanistic insights into MPs-induced renal injury and identifies STAT1 as a potential therapeutic target.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102924"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145462483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Improvement of radiotherapy with an ozone-carried liposome nano-system for synergizing cancer immune checkpoint blockade” [Nano Today 47 (2022) 101675] “臭氧携带的脂质体纳米系统用于协同癌症免疫检查点阻断的放射治疗的改进”的更正[Nano Today 47 (2022) 101675]

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-09-02 DOI: 10.1016/j.nantod.2025.102881

Dan Zheng , Yanchu Li , Linlin Song , Tianyue Xu , Xian Jiang , Xiaomeng Yin , Yinbo He , Jinshun Xu , Xuelei Ma , Li Chai , Jie Xu , Jianping Hu , Peng Mi , Jing Jing , Hubing Shi

引用次数: 0

Straight to the core: Intratumoral delivery of pitavastatin and miR-338–5p through lipid nanoparticles inhibits glioblastoma growth 直达核心：瘤内通过脂质纳米颗粒递送匹伐他汀和miR-338-5p可抑制胶质母细胞瘤的生长

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1016/j.nantod.2025.102954

João Basso , José Sereno , Ana Miguel Matos , Rui Oliveira , Maria Luísa Ramos , Miguel Castelo-Branco , Ana Fortuna , Rui Vitorino , Carla Vitorino

{"title":"Straight to the core: Intratumoral delivery of pitavastatin and miR-338–5p through lipid nanoparticles inhibits glioblastoma growth","authors":"João Basso , José Sereno , Ana Miguel Matos , Rui Oliveira , Maria Luísa Ramos , Miguel Castelo-Branco , Ana Fortuna , Rui Vitorino , Carla Vitorino","doi":"10.1016/j.nantod.2025.102954","DOIUrl":"10.1016/j.nantod.2025.102954","url":null,"abstract":"<div><div>Over the last decades, only minimal therapeutic advances in the field of glioblastoma have been achieved. In spite of the approval of temozolomide, the 2-year survival rate of these patients is below 30 %. In this work, the development of cationic nanostructured lipid carriers (NLCs) for the co-delivery of pitavastatin and miR-338–5p, termed <sub>PT</sub>NLCs:PAH:miR-338–5p, is explored. The results show an intracellular delivery of the cargo with subsequent transfection, target gene (NDFIP1, RHEB and PPP2R5A) knockdown and cytotoxicity at low µM concentrations of the carrier. This prototype also blocks spheroids growth within 72 h of treatment, resulting in the smallest cell aggregates (524 ± 40 µm <em>vs</em>. 1089 ± 29 µm for the control) at day 17. Biodistribution studies show an increased brain permeation for <sub>PT</sub>NLCs after intravenous administration and a significant brain accumulation of <sub>PT</sub>NLCs:PAH:miR-338–5p up to 48 h after one intracerebral injection. Lastly, the efficacy of the carriers was assessed in an orthotopic glioblastoma model through magnetic resonance imaging. After three local injections, the carrier was able to promote tumor regression, leading to 80 % of long-term survivors with a median survival over 60 days, contrasting to saline and temozolomide (12 and 41 days, respectively). Altogether, this preclinical proof of concept study opens new perspectives and supports the use of this prototype as a functional and effective tool for drug and gene delivery, with ability to respond to the aggressiveness of glioblastoma.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102954"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoengineered living macrophages as ultrasound imaging-trackable cell extinguishers inhibit pyroptosis in atherosclerotic plaque 纳米工程活巨噬细胞作为超声成像可追踪细胞灭火剂抑制动脉粥样硬化斑块的焦亡

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2026-01-05 DOI: 10.1016/j.nantod.2025.102972

Zheng Zhang , Jiahuan Xu , Meiqi Chang , Xinran Song , Wei Feng , Li Ding , Yu Chen , Bo Zhang

{"title":"Nanoengineered living macrophages as ultrasound imaging-trackable cell extinguishers inhibit pyroptosis in atherosclerotic plaque","authors":"Zheng Zhang , Jiahuan Xu , Meiqi Chang , Xinran Song , Wei Feng , Li Ding , Yu Chen , Bo Zhang","doi":"10.1016/j.nantod.2025.102972","DOIUrl":"10.1016/j.nantod.2025.102972","url":null,"abstract":"<div><div>Pyroptosis is a form of programmed cell death (PCD) that bolsters local and systemic inflammatory responses, which is closely associated with atherosclerosis (AS) progression and plaque vulnerability. Although current treatments have achieved satisfactory progress in suppressing pyroptosis, there are significant challenges remaining in effectively alleviating plaque burden due to issues including poor site specificity, extensive systemic distribution, and undesirable side effects. Herein, intelligent living cell-based drug delivery systems (LC-DDSs) targeting AS intervention with distinct functions was designed by loading disulfiramand (DSF) and the phase-transition perfluorohexane (PFH) onto the bovine serum albumin (BSA)-modified Co<sub>2</sub>Mo<sub>3</sub>O<sub>8</sub> nanosheets, followed by phagocytosis into macrophages to construct PDCos@Ms. Upon ultrasonic irradiation, these nanoengineered PDCos@Ms can generate microbubbles, enabling controlled release of their therapeutic payloads. This mechanism effectively ameliorates AS progression and enhances plaque stability by suppressing programmed cell pyroptosis and promoting an anti-inflammatory macrophage phenotype through scavenging reactive oxygen species, reducing the expression of pyroptosis-associated proteins and diminishing the leakage of inflammatory factors. Meanwhile, the PFH integrated within the system facilitate real-time ultrasonic imaging, allowing for image-guided atherosclerotic therapy. The proposed biomimetic therapeutic strategy holds significant potential for efficient plaque diminishing and provides a distinct paradigm of LC-DDSs for AS management.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102972"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold nanoclusters - A promising atomically precise atomic aggregation-based drug and its biomedical applications 金纳米团簇——一种很有前途的基于原子精确原子聚集的药物及其生物医学应用

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2026-01-21 DOI: 10.1016/j.nantod.2026.102985

Chao Xu , Yuan Zhang , Chunyu Zhang , Xueyun Gao

{"title":"Gold nanoclusters - A promising atomically precise atomic aggregation-based drug and its biomedical applications","authors":"Chao Xu , Yuan Zhang , Chunyu Zhang , Xueyun Gao","doi":"10.1016/j.nantod.2026.102985","DOIUrl":"10.1016/j.nantod.2026.102985","url":null,"abstract":"<div><div>Gold nanoclusters (Au NCs) are regarded as the most promising nanomedicine due to their precise structure composition, good biocompatibility, faster kidney clearance, and distinctive biological effects. They have demonstrated excellent potential in inhibiting tumors, antiviral, and antibacterial activities, as well as immunomodulatory effects. Simultaneously, the biological effects of Au NCs are significantly impacted by the synthetic strategies employed during their fabrication. In this review article, we have summarized the synthetic strategy used to achieve good biocompatibility of atomically precise Au NCs and highlight their biological effect and potential applications as biomedical drugs. The biological effects of Au NCs can be determined by their structure and composition. Therefore, various synthesis strategies for obtaining biocompatible Au NCs are summarized. Their physicochemical properties, biosafety, and metabolic characteristics are also discussed. Secondly, we explore the biomedical applications of Au NCs in therapeutics and drug delivery, highlighting the opportunities they present for antitumor, antiviral, antibacterial, and immune regulation applications. Finally, we provide an outlook on the current status and future efforts surrounding the synthesis and biomedical applications of Au NCs. We hope this review article will provide a comprehensive synthetic strategy to obtain the atomically precise Au NCs with good biocompatibility and give a comprehensive understanding of their biomedical application.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102985"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outside Back Cover - Graphical abstract TOC/TOC in double column/Cover image legend if applicable, Bar code, Abstracting and Indexing information 封底外-图形摘要TOC/双栏TOC/封面图例（如适用），条形码，摘要和索引信息

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-12-01 DOI: 10.1016/S1748-0132(25)00314-7

引用次数: 0