Nano TodayPub Date : 2026-02-01Epub Date: 2025-10-04DOI: 10.1016/j.nantod.2025.102913
Li Xu , Jiaqian Miao , Danni Xu , Xuan Mo , Junjie Wang , Sisi Chen , Bing Liu , Guangbo Ge , Xinyuan Zhu , Hongping Deng
{"title":"Corrigendum to “Macrophage-targeted polysaccharide nano-immunomodulators with spatial- and time-programmed drug release for cancer therapy” [Nano Today 66 (2026) 102893]","authors":"Li Xu , Jiaqian Miao , Danni Xu , Xuan Mo , Junjie Wang , Sisi Chen , Bing Liu , Guangbo Ge , Xinyuan Zhu , Hongping Deng","doi":"10.1016/j.nantod.2025.102913","DOIUrl":"10.1016/j.nantod.2025.102913","url":null,"abstract":"","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102913"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2026-02-01Epub Date: 2026-01-08DOI: 10.1016/j.nantod.2026.102976
Xiaohui Lin , Anshi Chu , Long Chen , Tianchi Zhang , Chenglin He , Ying Huangfu , Wei Li , Zucheng Zhang , Ting Kang , Xidong Duan
{"title":"Controlled epitaxy of perovskite van der waals heterostructures enables advanced self-powered broadband photodetectors","authors":"Xiaohui Lin , Anshi Chu , Long Chen , Tianchi Zhang , Chenglin He , Ying Huangfu , Wei Li , Zucheng Zhang , Ting Kang , Xidong Duan","doi":"10.1016/j.nantod.2026.102976","DOIUrl":"10.1016/j.nantod.2026.102976","url":null,"abstract":"<div><div>The development of high-performance, low-power photodetectors remains a central goal in optoelectronics. Van der Waals heterostructures integrating perovskites with two-dimensional (2D) transition-metal dichalcogenides (TMDs) offer promising potential. However, the efficient and precise integration of three-dimensional (3D) perovskites with 2D TMDs has been limited by poor thickness control and low interfacial quality. Here, the efficient and controllable epitaxy of CsPbBr<sub>3</sub>/WS<sub>2</sub> p-n heterostructures via a two-step chemical vapor deposition is reported. By tuning the growth temperature and employing rapid cooling, ultrathin CsPbBr<sub>3</sub> nanosheets down to 3 nm are achieved with excellent uniformity and interfacial quality. Photoluminescence quenching and shortened decay times confirm efficient interfacial electron transfer, with time-resolved spectra revealing thickness-dependent electron diffusion. The resulting CsPbBr<sub>3</sub>/WS<sub>2</sub> diode exhibits a current rectification ratio of 379, low reverse dark current (4 ×10⁻<sup>13</sup> A), and operates as a self-powered photodetector with high responsivity (12.6 A/W), detectivity (9.32 ×10<sup>13</sup> Jones), fast response (decay time of 498 μs), and broadband sensitivity (375–808 nm). This study not only provides a versatile approach for the controllable synthesis of high-quality perovskite/TMDs heterostructures, but also sets the stage for the development of high-performance optoelectronic devices.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102976"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2026-02-01Epub Date: 2025-12-16DOI: 10.1016/j.nantod.2025.102961
Weili Han , Feng Zeng , Kaikai Fu , Wenjie Lin , Zheng Cheng , Chang Li , Jun Chen , Yuanman Yu , Qiyong Mei
{"title":"A dual-targeting nanozyme platform integrating macrophage hitchhiking and TfR transcytosis for precision therapy of ischemic stroke","authors":"Weili Han , Feng Zeng , Kaikai Fu , Wenjie Lin , Zheng Cheng , Chang Li , Jun Chen , Yuanman Yu , Qiyong Mei","doi":"10.1016/j.nantod.2025.102961","DOIUrl":"10.1016/j.nantod.2025.102961","url":null,"abstract":"<div><div>Ischemic stroke, a critical neurological disorder resulting from abrupt cerebral blood flow interruption, remains a leading cause of global mortality and chronic disability. Despite advancements in reperfusion therapies, many survivors still suffer significant neurological deficits, primarily attributed to ischemia-reperfusion injury-induced oxidative stress and neuroinflammation. To address these challenges, we designed cerium-curcumin hybrid nanoparticles (Ce-Cur NPs) by leveraging the coordination interaction between redox-active cerium ions and curcumin’s β-diketone moiety. These Ce-Cur NPs were engineered to alleviate ROS-mediated secondary injuries and promote neural repair by leveraging their remarkable ROS scavenging capabilities, which mimic enzymatic activities to effectively neutralize superoxide and hydroxyl radicals. Furthermore, M1 polarized macrophage-derived membranes were employed to enhance the targeted delivery of Ce-Cur NPs to ischemic regions, while transferrin receptor (TfR)-activated peptides enabled efficient receptor-mediated transcytosis across the blood-brain barrier. In vivo studies using a middle cerebral artery occlusion (MCAO) model demonstrated that TfR-M<sub>1</sub>-Ce-Cur NPs successfully localized to the ischemic brain, significantly reduced infarct volume, and preserved neuronal integrity. Enhanced neurogenesis and improved functional recovery were observed, underscoring the therapeutic potential of Ce-Cur NPs as a versatile platform for ischemic stroke treatment. This approach provides a robust and evidence-based solution to enhance clinical outcomes for patients with ischemic stroke.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102961"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2026-02-01Epub Date: 2025-09-10DOI: 10.1016/j.nantod.2025.102897
Kexuan Zou , Yan Liu , Linlin Tang , Yuqi Wang , Jianming Wang , Jie Song
{"title":"Nucleic acid nanomaterials: Mechanisms and strategies for regulating innate immune activation","authors":"Kexuan Zou , Yan Liu , Linlin Tang , Yuqi Wang , Jianming Wang , Jie Song","doi":"10.1016/j.nantod.2025.102897","DOIUrl":"10.1016/j.nantod.2025.102897","url":null,"abstract":"<div><div>Nucleic acid nanomaterials (NA-NMat) are rapidly emerging as pivotal tools in precision medicine and therapeutic interventions, with their immunomodulatory roles attracting frontier research focuses. As key triggers of innate immunity, nucleic acids orchestrate complex immune regulations through their distinct structural motifs and sequence-dependent molecular recognition. Elucidating the molecular mechanisms by which nucleic acids activate the innate immune system not only helps to reveal their central roles in immune regulation, but also lays the theoretical foundation for developing innovative nucleic acid-based therapeutic strategies. In this review, we systematically summarize current knowledge regarding the activation pathways, sequence specificity, and conformational effects of nucleic acids including the primary, secondary, tertiary, and artificially designed structures of DNA and RNA in innate immunity. We further review recent advancements in utilizing NA-NMat integrated with oligonucleotides, proteins, and small molecules to co-regulate innate immunity. To conclude, we critically evaluate current challenges in the field and propose future directions for the development of nucleic acid nanotechnology (NA-NTech) in immunotherapy, offering insights and references for designing next-generation immune-regulatory nanoplatforms.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102897"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2026-02-01Epub Date: 2025-09-29DOI: 10.1016/j.nantod.2025.102904
Avital Ella Ben-Haim , Reut Amar Feldbaum , Uri Perry , Antolin Jesila Jesu Amalraj , Karthik Ananth Mani , Einat Zelinger , Einat Native-Roth , Mohamed Samara , Aviv Dombrovsky , Guy Mechrez
{"title":"Stimuli-responsive halloysite colloidosomes for active delivery of antiviral agents in plant protection","authors":"Avital Ella Ben-Haim , Reut Amar Feldbaum , Uri Perry , Antolin Jesila Jesu Amalraj , Karthik Ananth Mani , Einat Zelinger , Einat Native-Roth , Mohamed Samara , Aviv Dombrovsky , Guy Mechrez","doi":"10.1016/j.nantod.2025.102904","DOIUrl":"10.1016/j.nantod.2025.102904","url":null,"abstract":"<div><div>This study introduces a novel root protection method against Tobamovirus, using thermally responsive water-in-oil colloidosomes stabilized by halloysite nanotubes (HNTs). These colloidosomes are formed <em>in situ</em> through a cost-effective process using HNTs, canola oil, water, and two trietoxysilanes: (3-aminopropyl)trietoxysilanes (APTES) and Dodecyltriethoxysilane (DTES). The combination of hydrophilic APTES and hydrophobic DTES allows precise control over emulsion type and enables the formation of stable colloidosomes. A key feature of this system is the solar-triggered release of chlorinated trisodium phosphate (Cl-TSP), an antiviral agent that disinfects the root area and inactivates viral particles. The amount and timing of Cl-TSP release were measured, demonstrating controlled and localized delivery. The formulation provided high protection in tomato plants, while remaining biofriendly and environmentally safe. This work offers a smart-release platform for effective and sustainable crop protection.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102904"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2026-02-01Epub Date: 2025-11-15DOI: 10.1016/j.nantod.2025.102930
Xiangyu Zhang , Yongnan Jiang , Bin Liu , Xinlu Yu , Bo Jia , Yulong Dong , Xinquan Gu , Jinru Xue , Kelong Fan , Yuhan Zhang
{"title":"Engineering nanozymes for theranostics in urological cancer","authors":"Xiangyu Zhang , Yongnan Jiang , Bin Liu , Xinlu Yu , Bo Jia , Yulong Dong , Xinquan Gu , Jinru Xue , Kelong Fan , Yuhan Zhang","doi":"10.1016/j.nantod.2025.102930","DOIUrl":"10.1016/j.nantod.2025.102930","url":null,"abstract":"<div><div>Urological malignancies are highly prevalent and lethal, with recurrence, late diagnosis, and therapeutic resistance compromising patient survival and quality of life. To address these challenges, tumor microenvironment (TME)-responsive strategies—particularly nanozyme-based catalytic systems—have emerged as promising solutions. Cascade catalytic nanozymes can be selectively activated within the TME to generate reactive oxygen species (ROS) through sequential enzyme-mimicking reactions. Moreover, they catalyze the depletion of intracellular antioxidants, amplifying oxidative stress and enhancing redox-driven therapeutic efficacy. These processes induce regulated cell death pathways such as ferroptosis and cuproptosis while reinforcing tumor immunogenicity. In addition, certain metal-based nanozymes act as imaging contrast agents, integrating diagnosis and therapy within a single platform. The diagnostic potential extends beyond traditional imaging and tissue assays, with urine emerging as a valuable, non-invasive biofluid for complementary analysis. This review summarizes recent progress in nanozyme-based catalytic nanomedicine for urological cancers, focusing on cascade catalytic mechanisms, material design, and multifunctional theranostic applications. Finally, the challenges and future directions of intelligent, urine-compatible, imaging-assisted, and clinically translatable nanozyme systems are discussed toward precision urologic oncology.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102930"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2026-02-01Epub Date: 2026-01-16DOI: 10.1016/j.nantod.2026.102980
Yi Hu , Chen Jiang , Mengran Xu , Zijian Hu , Wei Jiang , Yexiang Sun , Junhui Song , Yanbin Zhang , Delin Hu , Kun Qu , Yunjiao Zhang , Jun Lin
{"title":"ZIF-8 nanoparticles alleviate cytokine release syndrome","authors":"Yi Hu , Chen Jiang , Mengran Xu , Zijian Hu , Wei Jiang , Yexiang Sun , Junhui Song , Yanbin Zhang , Delin Hu , Kun Qu , Yunjiao Zhang , Jun Lin","doi":"10.1016/j.nantod.2026.102980","DOIUrl":"10.1016/j.nantod.2026.102980","url":null,"abstract":"<div><div>Cytokine release syndrome (CRS) is a critical condition involving an excessive immune response that can result in multiple organ dysfunction and potentially fatal outcomes. Here, we revealed that monocytes from CRS patients highly expressed multiple proinflammatory cytokines in single-cell RNA sequencing data. ZIF-8, a widely employed nanodrug carrier, effectively inhibits the release of diverse pro-inflammatory cytokines and suppresses NLRP3, AIM2, and NLRC4 inflammasome activation. Mechanistic studies using ATAC-seq showed that ZIF-8 inhibited the lipopolysaccharide (LPS)-induced inflammation by preventing nuclear entry of pNF-κB and IRF2. Additionally, ZIF-8 inhibited the activation of NLRP3, NLRC4, and AIM2 inflammasomes by reducing ASC specks formation. In two mouse models of CRS induced by anti-CD3 antibody therapy and LPS, ZIF-8 extends the survival of CRS mice by reducing pro-inflammatory cytokine levels. This study highlights the potential of ZIF-8 in modulating inflammation for therapeutic purposes. Additionally, it also emphasizes the consideration of ZIF-8’s immunomodulatory properties when utilizing it as a carrier in the formulation of nanomedicine.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102980"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145972873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2026-02-01Epub Date: 2025-09-12DOI: 10.1016/j.nantod.2025.102894
Xiangjun Ou , Xiong Liu , Qi Qiao , Xiaonan Li , Zhangxi Xu , Tianyi Tian , Yang Li , Ling Tang , Tianzi Shi , Li Kong , Zhiping Zhang
{"title":"Pulmonary delivery of dynamic size-switching microspheres for regulation of neutrophils and macrophages in the acute respiratory distress syndrome","authors":"Xiangjun Ou , Xiong Liu , Qi Qiao , Xiaonan Li , Zhangxi Xu , Tianyi Tian , Yang Li , Ling Tang , Tianzi Shi , Li Kong , Zhiping Zhang","doi":"10.1016/j.nantod.2025.102894","DOIUrl":"10.1016/j.nantod.2025.102894","url":null,"abstract":"<div><div>Modulation of the interaction between neutrophils and macrophages is pivotal for controlling the inflammatory response in acute respiratory distress syndrome (ARDS). To enhance pulmonary drug deposition efficiency and simultaneously regulate macrophages and neutrophils, dynamic size-switching microsphere complexes (DNMP) were synthesized based on a double emulsion formulation strategy, utilizing acetalated dextran (Ac-Dextran) as the matrix material and co-encapsulated roflumilast-loaded albumin nanoparticles (BNP) and dexamethasone (DEX). DNMP exhibited high uniformity and encapsulation efficiency. Upon pulmonary administration, the micron-sized DNMP demonstrated remarkable deposition efficiency in the lungs, with a pulmonary retention time exceeding 48 h. Within the acidic microenvironment of inflamed lung, DNMP rapidly disintegrated, thereby releasing the co-encapsulated BNP and DEX. The BNP exhibited specific targeting towards neutrophils, subsequently releasing roflumilast to exert potent anti-inflammatory effects. Meanwhile, DEX modulated macrophage polarization and the overall inflammatory microenvironment, thereby contributing to a comprehensive and synergistic therapeutic strategy for mitigating pulmonary inflammation. As expected, DNMP alleviated lung injury by reducing neutrophil infiltration, decreasing the proportion of pro-inflammatory M1-like macrophages, suppressing inflammatory cytokine and ROS levels, and inhibiting neutrophil extracellular traps (NETs) formation. This innovative acid-responsive dual-drug delivery system provided a promising therapeutic strategy for ARDS.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102894"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2026-02-01Epub Date: 2025-09-13DOI: 10.1016/j.nantod.2025.102891
Pengchen Wang , Jintong Na , Xiyu Liu , Minhui Cui , Ganghao Liang , Xinyue He , Haihua Xiao , Yongxiang Zhao , Yuan Liao , Liping Zhong
{"title":"Sonodynamic biodegradable pseduo-conjugate polymer delivery of warfarin for inducing generation of cancerous ROS and ferroptosis","authors":"Pengchen Wang , Jintong Na , Xiyu Liu , Minhui Cui , Ganghao Liang , Xinyue He , Haihua Xiao , Yongxiang Zhao , Yuan Liao , Liping Zhong","doi":"10.1016/j.nantod.2025.102891","DOIUrl":"10.1016/j.nantod.2025.102891","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, characterized by low immune response rates and high recurrence. This underscores an urgent need for more effective treatment strategies for liver cancer patients. Ferroptosis, a type of cell death associated with iron-dependent lipid peroxidation, has shown significant potential in HCC treatment. However, the efficacy of this monotherapy for tumor treatment remains limited. Enhancing reactive oxygen species (ROS) accumulation and lipid peroxide formation by inhibiting the tumor cell antioxidant system has emerged as a promising anti-tumor strategy. In this study, we developed a nanoplatform, NP (nanoparticle)-BSD@WFR, specifically tailored for HCC treatment. This system combines a biodegradable sonodynamic polymer (BSD) with warfarin (WFR), a VKORC1L1 inhibitor that prevents intracellular peroxide elimination and enhances ferroptosis. Under ultrasound irradiation, NP-BSD@WFR generates ROS and releases WFR, directly targeting cancer cells. Concurrently, ROS and WFR synergistically enhance lipid peroxide production in cancer cells, triggering ferroptosis and activating the immune system. Animal studies further demonstrate that combining sonodynamic therapy with WFR-induced ferroptosis produces a synergistic anti-tumor effect, promoting a strong immune response in vivo. This study introduces an innovative therapeutic approach combining sonodynamic therapy and WFR for HCC treatment and highlights its promising efficacy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102891"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}