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Dynamics of catalyst nanoparticles quantified from in situ TEM video 从原位 TEM 视频中量化催化剂纳米颗粒的动态变化
IF 13.2 1区 材料科学
Nano Today Pub Date : 2024-09-24 DOI: 10.1016/j.nantod.2024.102505
Shuhui Liu , Qiao Zhao , Shaobo Han , Zhenghao Jia , Xiaoling Hong , Wei Liu
{"title":"Dynamics of catalyst nanoparticles quantified from in situ TEM video","authors":"Shuhui Liu ,&nbsp;Qiao Zhao ,&nbsp;Shaobo Han ,&nbsp;Zhenghao Jia ,&nbsp;Xiaoling Hong ,&nbsp;Wei Liu","doi":"10.1016/j.nantod.2024.102505","DOIUrl":"10.1016/j.nantod.2024.102505","url":null,"abstract":"<div><div>Quantification of the restructuring and migrating behaviors of working nanocatalysts at high spatiotemporal resolution is of a rigorous challenge but of vital significance to provide insights into the microstructural intrinsic of catalytic stability under the stimuli of the reaction environment. In this work, a deep learning-driven <em>in situ</em> TEM video quantification has been developed, capable of identifying and tracking every nanoparticle within the multi-particles video recorded during catalytic reaction. Through this methodology, evolutionary tracks of NiAu particles during catalyzing CO<sub>2</sub> hydrogenation and CuPd particles in a redox environment have been resolved. These quantitative behaviors of reconstruction and migration derived from <em>in situ</em> TEM data, for the first time, unravel the surface-anisotropic catalytic reaction over individual particle, which is consistently measured as multiple changing descriptors including particle diameter/area, circularity, and migration velocity. Such reaction and microstructure inhomogeneity deconstructed from working nanocatalyst offers convincing elucidation about the micro-dynamic mechanism of catalyst coalescence and migration. This paper highlights the merits of interdisciplinary study rooting in artificial intelligence-driven <em>in situ</em> TEM analysis.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102505"},"PeriodicalIF":13.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142316198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A chorismate mutase-targeted, core-shell nanoassembly-activated SERS immunoassay platform for rapid non-invasive detection of Acanthamoeba infection 用于快速无创检测棘阿米巴感染的络氨酸突变酶靶向核壳纳米组装激活型 SERS 免疫测定平台
IF 13.2 1区 材料科学
Nano Today Pub Date : 2024-09-21 DOI: 10.1016/j.nantod.2024.102506
Hyerin Lee , Min-Jeong Kim , Junkyu Chung , Wansun Kim , Hye-Jeong Jo , Tae Gi Kim , Jae-Ho Shin , Gi-Ja Lee , Fu-Shi Quan , Hyun-Hee Kong , Sang Woong Moon , Eun-Kyung Moon , Samjin Choi
{"title":"A chorismate mutase-targeted, core-shell nanoassembly-activated SERS immunoassay platform for rapid non-invasive detection of Acanthamoeba infection","authors":"Hyerin Lee ,&nbsp;Min-Jeong Kim ,&nbsp;Junkyu Chung ,&nbsp;Wansun Kim ,&nbsp;Hye-Jeong Jo ,&nbsp;Tae Gi Kim ,&nbsp;Jae-Ho Shin ,&nbsp;Gi-Ja Lee ,&nbsp;Fu-Shi Quan ,&nbsp;Hyun-Hee Kong ,&nbsp;Sang Woong Moon ,&nbsp;Eun-Kyung Moon ,&nbsp;Samjin Choi","doi":"10.1016/j.nantod.2024.102506","DOIUrl":"10.1016/j.nantod.2024.102506","url":null,"abstract":"<div><p>Contact lens care and early diagnosis of <em>Acanthamoeba</em> keratitis (AK) are very important to prevent progression to blindness due to AK, which develops when <em>Acanthamoeba</em> attaches to contact lens-damaged corneas. Therefore, we propose a novel, non-invasive, immuno-surface-enhanced Raman scattering (SERS) sensing platform for rapid and accurate detection of <em>Acanthamoeba</em> infection in the tears and contact lens solutions of humans. This optic analysis method was based on the proven biological performance of chorismate mutase (CM)<em>-</em>specific monoclonal and polyclonal antibodies on trophozoite and cyst forms of <em>Acanthamoeba castellanii,</em> and its conditioned media. SERS-based, ultra-low concentration detection was achieved by the anisotropic fanblade-shaped core-shell nanoassembly (Ag@AuFNP) embedded with 4-fluorobenzenethiol Raman reporter. The immuno-SERS platform combining Ag@AuFNP and CM-specific antibody complexes was evaluated <em>in vitro</em> and <em>in vivo</em>. The non-invasive SERS-activated biosensing platform indicates strong feasibility for AK detection in human tears and contact lens solutions.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102506"},"PeriodicalIF":13.2,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A cationic hydrogel with anti-IL-17A-specific nanobodies for rheumatoid arthritis treatment via inhibition of inflammatory activities of neutrophils 一种含有抗 IL-17A 特异性纳米抗体的阳离子水凝胶,可通过抑制中性粒细胞的炎症活动治疗类风湿性关节炎
IF 13.2 1区 材料科学
Nano Today Pub Date : 2024-09-20 DOI: 10.1016/j.nantod.2024.102507
Qiaoxuan Wang , Qi Cheng , Guangshuai Yao , Zhaolong Wang , Lingjiang Zhu , Zhiru Zeng , Lingyun Jia , Yan Du , Jing Xue , Changyou Gao
{"title":"A cationic hydrogel with anti-IL-17A-specific nanobodies for rheumatoid arthritis treatment via inhibition of inflammatory activities of neutrophils","authors":"Qiaoxuan Wang ,&nbsp;Qi Cheng ,&nbsp;Guangshuai Yao ,&nbsp;Zhaolong Wang ,&nbsp;Lingjiang Zhu ,&nbsp;Zhiru Zeng ,&nbsp;Lingyun Jia ,&nbsp;Yan Du ,&nbsp;Jing Xue ,&nbsp;Changyou Gao","doi":"10.1016/j.nantod.2024.102507","DOIUrl":"10.1016/j.nantod.2024.102507","url":null,"abstract":"<div><p>Rheumatoid arthritis (RA) is a chronic inflammatory joint disease primarily driven by inappropriate infiltration and activation of immune cells and pro-inflammatory cytokines. Among them, neutrophils with high plasticity play a pathogenic role in RA by abnormal neutrophil immune activities. As anti-IL-17A therapies failed to achieve long-term ideal therapeutic outcomes in clinical trials, we speculated that the underlying cause may be associated with the abnormal activity of neutrophils that have a direct link to IL-17A. Herein, we created a cationic hydrogel loaded with anti-IL-17A nanobodies (Nbs) capable of synergistically weakening the inflammatory activities of neutrophils and relieving inflammation in RA. Based on the host-guest interaction, the hydrogel was comprised of β-cyclodextrin-modified hyperbranched polylysine (HBPL-CD) and adamantane-modified hyaluronic acid (HA-Ad). The physical properties were adjusted to match the mechanical environment of joints and enable injection. The hydrogel with Nbs could adsorb cell-free DNA (cfDNA) persistently and slowly release anti-IL-17A Nbs, which synergistically alleviated the inflammatory activities of neutrophils via inhibiting the IL-17A stimulated neutrophil extracellular traps (NETs) of neutrophils from RA patients and mice with collagen-induced arthritis (CIA), reducing the level of pro-inflammatory cytokines, and suppressing the inflammatory phenotype of neutrophils <em>in vitro</em>. The ankle injection of the hydrogel with Nbs into a mouse model of CIA could alleviate the RA symptoms <em>in vivo</em>. This novel platform is believed to provide a guideline for treating IL-17A-related diseases by combining Nbs with the immunoregulation of neutrophils.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102507"},"PeriodicalIF":13.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thermoelectric catalysis overcomes tumour “marginalization” of cytotoxic T-lymphocytes to boost immune checkpoint blockade therapy 热电催化克服肿瘤对细胞毒性 T 淋巴细胞的 "边缘化",促进免疫检查点阻断疗法的发展
IF 13.2 1区 材料科学
Nano Today Pub Date : 2024-09-19 DOI: 10.1016/j.nantod.2024.102500
Chang Liu , Xuwu Zhang , Wenkang Tu , Kelong Fan , Xiyun Yan , Yuchu He , Dawei Gao
{"title":"Thermoelectric catalysis overcomes tumour “marginalization” of cytotoxic T-lymphocytes to boost immune checkpoint blockade therapy","authors":"Chang Liu ,&nbsp;Xuwu Zhang ,&nbsp;Wenkang Tu ,&nbsp;Kelong Fan ,&nbsp;Xiyun Yan ,&nbsp;Yuchu He ,&nbsp;Dawei Gao","doi":"10.1016/j.nantod.2024.102500","DOIUrl":"10.1016/j.nantod.2024.102500","url":null,"abstract":"<div><p>Although immune checkpoint blockade (ICB) therapy enhances the tumour recognition of cytotoxic T lymphocytes (CTLs), the limited infiltration of CTLs into the centre of solid tumours significantly restricts the effect of ICB therapy. Herein, we showed that increased tumour interstitial fluid pressure (TIFP) is a critical factor in the tumour “marginalization” of CTLs. Additionally, we utilized a spatiotemporally controllable thermoelectric catalytic nanodrug (BF@M) to decompose water from the tumour interstitial fluid into oxygen, effectively reducing the TIFP and leading to enhanced infiltration of CTLs from the periphery to the interior of the solid tumour. The results revealed that BF@M significantly increased the intratumor infiltration of CTLs in three different tumour-bearing mouse models, with a maximum increase of 18.1 times. Overall, this study highlighted the intrinsic relationship between TIFP and CTLs infiltration and the mechanism underlying the effect of the TIFP, successfully addressing the tumour “marginalization” of CTLs to enhance ICB therapy.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":""},"PeriodicalIF":13.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brillouin light scattering spectral fingerprinting of magnetic microstates in artificial spin ice 人工自旋冰中磁性微态的布里渊光散射光谱指纹图谱
IF 13.2 1区 材料科学
Nano Today Pub Date : 2024-09-18 DOI: 10.1016/j.nantod.2024.102497
Amrit Kumar Mondal , Avinash Kumar Chaurasiya , Kilian D. Stenning , Alex Vanstone , Jack C. Gartside , Will R. Branford , Anjan Barman
{"title":"Brillouin light scattering spectral fingerprinting of magnetic microstates in artificial spin ice","authors":"Amrit Kumar Mondal ,&nbsp;Avinash Kumar Chaurasiya ,&nbsp;Kilian D. Stenning ,&nbsp;Alex Vanstone ,&nbsp;Jack C. Gartside ,&nbsp;Will R. Branford ,&nbsp;Anjan Barman","doi":"10.1016/j.nantod.2024.102497","DOIUrl":"10.1016/j.nantod.2024.102497","url":null,"abstract":"<div><p>The family of nanomagnetic arrays termed artificial spin ice (ASI) possess a vast range of metastable microstates. These states exhibit both exotic fundamental physics and more recently applied functionality, garnering attention as reconfigurable magnonic circuits and neuromorphic computing platforms. However, open questions remain on the role of microstate imperfections or angular disorder – particularly in the GHz response of the system. We report a study on the GHz dynamics of a series of five carefully prepared microstates in the same ASI sample, with both coexistence of vortex and uniformly magnetized macrospins, and disorder in the orientation of the macrospins at different vertices. We observe microstate-specific mode frequency shifting, mode creation and mode crossing. This versatility of characteristic spin-wave (SW) peaks for specific magnetic microstates in ASI enables identification of microstate configurations via SW spectral characterization. The wide reconfigurability of microstate-specific SW dynamics also opens avenues for developing rich magnonic devices operating in the GHz frequency regime and advances the understanding of ASI physics.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102497"},"PeriodicalIF":13.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Layer-by-layer growth of bilayer graphene single-crystals enabled by proximity catalytic activity 通过近距离催化活性实现双层石墨烯单晶的逐层生长
IF 13.2 1区 材料科学
Nano Today Pub Date : 2024-09-17 DOI: 10.1016/j.nantod.2024.102482
Zhihong Zhang , Linwei Zhou , Zhaoxi Chen , Antonín Jaroš , Miroslav Kolíbal , Petr Bábor , Quanzhen Zhang , Changlin Yan , Ruixi Qiao , Qing Zhang , Teng Zhang , Wei Wei , Yi Cui , Jingsi Qiao , Liwei Liu , Lihong Bao , Haitao Yang , Zhihai Cheng , Yeliang Wang , Enge Wang , Zhu-Jun Wang
{"title":"Layer-by-layer growth of bilayer graphene single-crystals enabled by proximity catalytic activity","authors":"Zhihong Zhang ,&nbsp;Linwei Zhou ,&nbsp;Zhaoxi Chen ,&nbsp;Antonín Jaroš ,&nbsp;Miroslav Kolíbal ,&nbsp;Petr Bábor ,&nbsp;Quanzhen Zhang ,&nbsp;Changlin Yan ,&nbsp;Ruixi Qiao ,&nbsp;Qing Zhang ,&nbsp;Teng Zhang ,&nbsp;Wei Wei ,&nbsp;Yi Cui ,&nbsp;Jingsi Qiao ,&nbsp;Liwei Liu ,&nbsp;Lihong Bao ,&nbsp;Haitao Yang ,&nbsp;Zhihai Cheng ,&nbsp;Yeliang Wang ,&nbsp;Enge Wang ,&nbsp;Zhu-Jun Wang","doi":"10.1016/j.nantod.2024.102482","DOIUrl":"10.1016/j.nantod.2024.102482","url":null,"abstract":"<div><p>Direct growth of large-area vertically stacked two-dimensional (2D) van der Waal (vdW) materials is a prerequisite for their high-end applications in integrated electronics, optoelectronics and photovoltaics. Currently, centimetre- to even metre-scale monolayers of single-crystal graphene (MLG) and hexagonal boron nitride (<em>h</em>-BN) have been achieved by epitaxial growth on various single-crystalline substrates. However, in principle, this success in monolayer epitaxy seems extremely difficult to be replicated to bi- or few-layer growth, as the full coverage of the first layer was believed to terminate the reactivity of those adopting catalytic metal surfaces. Here, we report an exceptional layer-by-layer chemical vapour deposition (CVD) growth of large size bi-layer graphene single-crystals, enabled by proximity catalytic activity from platinum (Pt) surfaces to the outermost graphene layers. <em>In-situ</em> growth and real-time surveillance experiments, under well-controlled environments, unambiguously verify that the growth does follow the layer-by-layer mode on open surfaces of MLG/Pt(111). First-principles calculations indicate that the transmittal of catalytic activity is allowed by an appreciable electronic hybridisation between graphene overlayers and Pt surfaces, enabling catalytic dissociation of hydrocarbons and subsequently direct graphitisation of their radicals on the outermost sp<sup>2</sup> carbon surface. This proximity catalytic activity is also proven to be robust for tube-furnace CVD in fabricating single-crystalline graphene bi-, tri- and tetra-layers, as well as <em>h</em>-BN few-layers. Our findings offer an exceptional strategy for potential controllable, layer-by-layer and wafer-scale growth of vertically stacked few-layered 2D single crystals.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102482"},"PeriodicalIF":13.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unravelling nanometallurgy with in situ transmission electron microscopy: A case-study with copper nanowires 利用原位透射电子显微镜揭示纳米冶金学:纳米铜线案例研究
IF 13.2 1区 材料科学
Nano Today Pub Date : 2024-09-17 DOI: 10.1016/j.nantod.2024.102485
D.S.R. Coradini , M.A. Tunes , C. Quick , P.D. Willenshofer , T.M. Kremmer , S. Luidold , P.J. Uggowitzer , S. Pogatscher
{"title":"Unravelling nanometallurgy with in situ transmission electron microscopy: A case-study with copper nanowires","authors":"D.S.R. Coradini ,&nbsp;M.A. Tunes ,&nbsp;C. Quick ,&nbsp;P.D. Willenshofer ,&nbsp;T.M. Kremmer ,&nbsp;S. Luidold ,&nbsp;P.J. Uggowitzer ,&nbsp;S. Pogatscher","doi":"10.1016/j.nantod.2024.102485","DOIUrl":"10.1016/j.nantod.2024.102485","url":null,"abstract":"<div><p>Technological advances constantly set new challenges for materials development. The miniaturisation of electronic devices demands the migration of metallurgy from macro/micro to the nanoscale, thus requiring a re-definition of existing and classical concepts in this field. The present study reports on the behaviour of pure Cu nanowires with diameters ranging from 40 to 140 nm heated in a low-pressure environment within a transmission electron microscope. The response of Cu nanowires was investigated at different temperatures up to 1123 K and analysed using electron-microscopy techniques, revealing both volumetric and shape changes over time. Sublimation, with a steady-state length reduction of the nanowires, was identified as the dominant effect of such heating. Additionally, it was detected that sublimation occurred not only at temperatures above ≈ 1023 K, where Cu has a higher vapour pressure than the column pressure of the electron-microscope, but also at temperatures as low as 923 K. This behaviour is explained by the presence of active regions at sharply curved regions at the nanowire tip and the imbalance of evaporation and redeposition rates of Cu atoms due to the experimentally-induced loss of vapor atoms. The study of Cu nanowires at the nanoscale with the electron microscope facilitates the elucidation of some fundamental aspects of the emerging science of nanometallurgy.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102485"},"PeriodicalIF":13.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1748013224003414/pdfft?md5=b09f94ef5aedfbdb7ae8d45362740f79&pid=1-s2.0-S1748013224003414-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of porous Se@SiO2 nanospheres and docetaxel exhibits anti-castration-resistant prostate cancer activity by downregulating ATG14-dependent autophagy 多孔Se@SiO2纳米球与多西他赛的组合通过下调ATG14依赖性自噬作用显示出抗前列腺癌的活性
IF 13.2 1区 材料科学
Nano Today Pub Date : 2024-09-16 DOI: 10.1016/j.nantod.2024.102499
Boyu Yang , Shiyun Liu , Tianming Cheng , Xijian Liu , Jian Song , Xuanhao Li , Fangzhou Zhao , Jingcheng Lv , Meishan Zhao , Mingjun Shi , Jun Li , Yanchun Quan , Guangjian Fan , Song Guo Zheng , Bangmin Han , Lianhui Sun
{"title":"Combination of porous Se@SiO2 nanospheres and docetaxel exhibits anti-castration-resistant prostate cancer activity by downregulating ATG14-dependent autophagy","authors":"Boyu Yang ,&nbsp;Shiyun Liu ,&nbsp;Tianming Cheng ,&nbsp;Xijian Liu ,&nbsp;Jian Song ,&nbsp;Xuanhao Li ,&nbsp;Fangzhou Zhao ,&nbsp;Jingcheng Lv ,&nbsp;Meishan Zhao ,&nbsp;Mingjun Shi ,&nbsp;Jun Li ,&nbsp;Yanchun Quan ,&nbsp;Guangjian Fan ,&nbsp;Song Guo Zheng ,&nbsp;Bangmin Han ,&nbsp;Lianhui Sun","doi":"10.1016/j.nantod.2024.102499","DOIUrl":"10.1016/j.nantod.2024.102499","url":null,"abstract":"<div><p>Chemotherapy remains the core anticancer treatment for castration-resistant prostate cancer (CRPC). However, drug resistance still poses a major obstacle, leading to shorter survival times. Given the biosafety of porous Se@SiO<sub>2</sub> nanospheres in normal tissues, their combination with chemotherapeutic drugs has emerged as an effective treatment for cancer. It is unknown whether porous Se@SiO<sub>2</sub> nanospheres can protect CRPC cells from drug resistance. In our study, we synthesized porous Se@SiO<sub>2</sub> nanospheres and confirmed their characteristics in line with previous studies. We discovered that porous Se@SiO<sub>2</sub> nanospheres sensitize CRPC to docetaxel (DTX) treatment, both <em>in vitro</em> and <em>in vivo</em>. Mechanistically, the nanospheres induce dephosphorylation of autophagy-related 14 (ATG14) at Y357 by upregulating the expression of the cellular form of prostatic acid phosphatase (cPAP) protein, which prevents the induction of autophagy and the survival of prostate cancer cells after DTX treatment. Furthermore, there is a negative correlation between cPAP and autophagy in CRPC. Our results suggest that the combination of porous Se@SiO<sub>2</sub> nanospheres with DTX could be a potentially effective treatment for CRPC.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102499"},"PeriodicalIF":13.2,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1748013224003554/pdfft?md5=10bece42a14811e866fd7cec1aca59ff&pid=1-s2.0-S1748013224003554-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic fractal ice nano-nucleators for cancer cryotherapy 用于癌症冷冻疗法的动态分形冰纳米核子
IF 13.2 1区 材料科学
Nano Today Pub Date : 2024-09-16 DOI: 10.1016/j.nantod.2024.102501
Min Jun Ko , Sanghee Lee , Yoo Sang Jeon , Dong-Hyun Kim
{"title":"Dynamic fractal ice nano-nucleators for cancer cryotherapy","authors":"Min Jun Ko ,&nbsp;Sanghee Lee ,&nbsp;Yoo Sang Jeon ,&nbsp;Dong-Hyun Kim","doi":"10.1016/j.nantod.2024.102501","DOIUrl":"10.1016/j.nantod.2024.102501","url":null,"abstract":"<div><p>We present cryo-responsive dynamic fractal ice nano-nucleators (DF-INNs) for cryo-cancer therapy applications. Our development of DF-INNs leverages their structural advantages, which inherently maximizes the number of active sites for heterogeneous ice nucleation. Owing to their radially attached nanocrystalline structure, DF-INNs expose an extensive array of grain boundaries. The rapid precipitation and subsequent radial attachments of nanocrystallites promote the exposure of facets with high Miller indices, intrinsically strained, five-fold twinned nanocrystals, and increasing point defects due to kinetically-limited precipitation. This unique fractal structure culminates in the elevating of freezing temperature compared to Euclidean-shaped ice nucleators. Additionally, the branched fractal structure of DF-INNs facilitates heterogenic ice formation within its nanoconfined region, leading to the production of numerous self-similar small fractal fragments. This fragmentation is primarily driven by nanoconfinement-induced delayed ice nucleation, similar to frost heaving. The shear stress can be easily relieved through grain boundary sliding within the radially stacked DF-INN, making itself prone to cryo-responsive fragmentation. Such dynamic attributes significantly enhance ice nucleating activity, presenting a powerful strategy to increase the efficacy of cryotherapy by enhancing cellular ice formation and <em>in vivo</em> tumor coverage.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102501"},"PeriodicalIF":13.2,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calibrated absolute optical contrast for high-throughput characterization of horizontally aligned carbon nanotube arrays 用于高通量鉴定水平排列碳纳米管阵列的校准绝对光学对比度
IF 13.2 1区 材料科学
Nano Today Pub Date : 2024-09-14 DOI: 10.1016/j.nantod.2024.102502
Yue Li , Ying Xie , Jianping Wang , Yang Xu , Shurui Wang , Yunbiao Zhao , Liu Qian , Ziqiang Zhao , Jin Zhang
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