Nano Today最新文献_第6页

Surface micro/nano-biomimetic structures regulate cellular energy metabolism to induce tissue regeneration 表面微纳米仿生结构调节细胞能量代谢，诱导组织再生

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-06 DOI: 10.1016/j.nantod.2025.102789

Yuxiang Zhang , Jingming Li , Linnan Wang , Jiajun Liu , Kai Zhang , Xingdong Zhang , Bo Yuan , Xiangdong Zhu

{"title":"Surface micro/nano-biomimetic structures regulate cellular energy metabolism to induce tissue regeneration","authors":"Yuxiang Zhang , Jingming Li , Linnan Wang , Jiajun Liu , Kai Zhang , Xingdong Zhang , Bo Yuan , Xiangdong Zhu","doi":"10.1016/j.nantod.2025.102789","DOIUrl":"10.1016/j.nantod.2025.102789","url":null,"abstract":"<div><div>Energy metabolism serves as a critical means through which the body modulates cellular differentiation and tissue regeneration processes, while the strategy of using materials to reprogram it for tissue regeneration remains a significant challenge. Here, we utilized plasma-induced technology to develop a hierarchical micro-nano-porous structure with bone-like heterogeneous properties on the surface of bioinert material. The in vitro studies indicated that the biomimetic morphology can influence the mitochondrion around the microtubules in BMSCs via stretching its cytoskeleton, which further triggers the intracellular oxidative phosphorylation pathway, thereby elevating ATP production and inducing cell osteogenic differentiation. Following implantation in rat femoral condyles and goat intervertebral defects, the implants rapidly promote interfacial osseointegration and induce bone regeneration. This study not only presents a novel strategy to address the clinical issue of biomaterials implantation failure but also provides valuable insights into the influence of material morphology on cellular metabolic energy and its underlying mechanisms.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102789"},"PeriodicalIF":13.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microneedle sensor for real-time monitoring of inflammatory cytokine signature 用于实时监测炎症细胞因子信号的微针传感器

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-03 DOI: 10.1016/j.nantod.2025.102777

Ziqi Gao , Ziyi Lu , Sheng Zhao , Jiahuan You , Junxia Wang , Shukun Gao , Wentao Zhang , Ruisi Cai , Shiqi Wang , Yingke Wu , Zexiang Wang , Junlin Li , Yuhang Bao , Qi Han , Yunlei Xianyu , Jicheng Yu , Zhen Gu , Yuqi Zhang

{"title":"Microneedle sensor for real-time monitoring of inflammatory cytokine signature","authors":"Ziqi Gao , Ziyi Lu , Sheng Zhao , Jiahuan You , Junxia Wang , Shukun Gao , Wentao Zhang , Ruisi Cai , Shiqi Wang , Yingke Wu , Zexiang Wang , Junlin Li , Yuhang Bao , Qi Han , Yunlei Xianyu , Jicheng Yu , Zhen Gu , Yuqi Zhang","doi":"10.1016/j.nantod.2025.102777","DOIUrl":"10.1016/j.nantod.2025.102777","url":null,"abstract":"<div><div>Monitoring of inflammatory levels provides crucial evaluation of pathology, facilitating the diagnosis of inflammatory diseases such as infection, allergy, and severe conditions like cytokine storms. Traditionally, the detection of cytokines and other inflammatory proteins requires blood sampling, a procedure that demands skilled personnel, poses infection risks, and can reduce patient compliance. Their low concentration, rapid degradation and complexity of sample preparation lead to false negatives and compromised detection sensitivity. In this study, we introduce a multi-target microneedle sensor capable of blood-free detection of multiple cytokines such as IL-6, IL-1<em>β</em>, TNF-<em>α</em> and C-reactive protein (CRP), offering a relatively comprehensive judgement of the inflammatory cytokine signature. The detection performance was assessed both <em>in vitro</em> and <em>in vivo</em>, with results visually observable at a semi-quantitative level within 30 minutes. This portable and minimally invasive sensor harnesses real-time, at-home monitoring of inflammatory status.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102777"},"PeriodicalIF":13.2,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-infrared light-induced self-assembled lanthanide nanoparticles for boosted radiosensitization and persistent tumor therapy monitoring 近红外光诱导的自组装镧系纳米粒子增强放射增敏和持续肿瘤治疗监测

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-02 DOI: 10.1016/j.nantod.2025.102782

Chunxiang Mo , Liping Fu , Hanxun Zou , Chuqiao Liu , Kang Zhu , Jingjing Cao , Jimei Wang , Huiqin Zhou , Dengxia Wang , Yan Sun , Ying Wu , Qunsheng Li , Jibin Song

{"title":"Near-infrared light-induced self-assembled lanthanide nanoparticles for boosted radiosensitization and persistent tumor therapy monitoring","authors":"Chunxiang Mo , Liping Fu , Hanxun Zou , Chuqiao Liu , Kang Zhu , Jingjing Cao , Jimei Wang , Huiqin Zhou , Dengxia Wang , Yan Sun , Ying Wu , Qunsheng Li , Jibin Song","doi":"10.1016/j.nantod.2025.102782","DOIUrl":"10.1016/j.nantod.2025.102782","url":null,"abstract":"<div><div>Cancer radiotherapy resistance is a significant barrier to achieving optimal radiotherapy outcomes, prompting the continuous emergence of radiation sensitizing agents. To enhance the retention of radiosensitizers at tumor sites and thereby amplify their radiosensitizing effects, a novel nanoparticle aggregation platform (DH&UH NPs) responsive to second near-infrared light was developed, integrating radiosensitization and biological imaging functionalities. The platform is comprised of hyaluronic acid derivatives modified lanthanide-doped down-conversion nanoparticles (DH NPs) and lanthanide-doped upconversion nanoparticles (UH NPs). Under 980 nm laser irradiation, UH NPs efficiently generate UV light, which induces a tramsformation of the hydroxyl groups on the surface-bound NB molecules of the UH NPs into aldehyde groups. The aldehyde groups would react with the amino groups on UH NPs and the hydrazine groups of DH NPs, forming stable nanoparticle aggregates. This innovative design not only prolongs the duration of tumor imaging but also ensures sustained retention of the radiosensitizer at the tumor site. Furthermore, the organic diselenide bond in HA derivatives, serving as a radiosensitizer, generated abundant reactive oxygen species under X-ray radiation, thereby significantly enhancing the radiosensitization effect. Therefore, this innovative approach holds great promise as a versatile tool for long-term tumor imaging and achieving ideal radiation therapy effects.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102782"},"PeriodicalIF":13.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering inhalable nanomedicines to navigate lung barriers for effective pulmonary fibrosis therapy 设计可吸入的纳米药物以穿越肺屏障，有效治疗肺纤维化

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-05-02 DOI: 10.1016/j.nantod.2025.102778

Jinyang Lu , Lin Sun , Dong Mei , Chao Liu , Tian Xia , Jiulong Li , Huan Meng

{"title":"Engineering inhalable nanomedicines to navigate lung barriers for effective pulmonary fibrosis therapy","authors":"Jinyang Lu , Lin Sun , Dong Mei , Chao Liu , Tian Xia , Jiulong Li , Huan Meng","doi":"10.1016/j.nantod.2025.102778","DOIUrl":"10.1016/j.nantod.2025.102778","url":null,"abstract":"<div><div>Pulmonary fibrosis (PF) is a chronic and progressive interstitial lung disease characterized by abnormal scarring of lung tissue, which severely impairs respiratory function and diminishes quality of life. Despite the availability of antifibrotic and immunosuppressive treatments, therapeutic outcomes remain limited. Inhalable nanomedicines represent a promising approach to address the limitations of traditional therapies by overcoming the lung’s complex physiological and pathological barriers, such as respiratory airflow dynamics, mucus absorption, macrophage clearance, surfactant interactions, and the influence of the lung microbiome. This review delves into the intricate interactions between inhalable nanoparticles and the lung environment, exploring recent advancements in nanotechnology that enable efficient and targeted drug delivery to the fibrotic lung. Key areas of focus include optimizing nanoparticle design, overcoming lung barriers, addressing the challenges of fibrotic pathology, and leveraging biomimetic and “smart” approaches for targeted therapies. This work aims to provide insights into the future of inhalable nanomedicines, paving the way for more effective, personalized treatments for pulmonary fibrosis with improved therapeutic outcomes and minimal side effects.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102778"},"PeriodicalIF":13.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial of low-concentration antisite defects LiFePO4 for boosting lithium ion capture 微生物对低浓度反位缺陷LiFePO4促进锂离子捕获

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-30 DOI: 10.1016/j.nantod.2025.102781

Jianhua Yuan , Xiaosong Gu , Xing Zhilin , Xiaochen Zhang , Jianglin Cao , Hong Chen , Fei Yu , Jie Ma

{"title":"Microbial of low-concentration antisite defects LiFePO4 for boosting lithium ion capture","authors":"Jianhua Yuan , Xiaosong Gu , Xing Zhilin , Xiaochen Zhang , Jianglin Cao , Hong Chen , Fei Yu , Jie Ma","doi":"10.1016/j.nantod.2025.102781","DOIUrl":"10.1016/j.nantod.2025.102781","url":null,"abstract":"<div><div>LiFePO<sub>4</sub> (LFP) is recognized as a promising electrode material for capturing lithium ions (Li<sup>+</sup>); however, the presence of antisite defects in LFP crystals blocks the one-dimensional (1D) diffusion channel along the b-axis, thereby slowing down Li<sup>+</sup> diffusion and compromising cycling stability. Herein, we propose a “microbial enzyme-catalyzed” green synthesis strategy, successfully preparing polymorphic LFPs characterized by a low concentration of antisite defects (< 3 %), resulting in enhanced ion transport and stable cycling performance. The low-concentration antisite defective LFP provided a smooth ion diffusion channel, enhancing both Li<sup>+</sup> diffusion and electron transport to effectively improve kinetics. Additionally, the carbon shell derived from <em>polyphosphorus</em> bacteria improved electrical conductivity and provided space to accommodate the volume expansion of LFP, ultimately enhancing cycling stability. Consequently, LFP@C-7 exhibited excellent Li<sup>+</sup> capture capacity (3.05 mmol g<sup>−1</sup>) and rate (1.01 mmol g<sup>−1</sup>min<sup>−1</sup>), with a high separation factor of 212 (Mg/Li ratio of 60) and excellent cycling stability (capacity retention exceeding 83.3 % over 100 cycles). Electrochemical quartz crystal microbalance (EQCM-D) analysis confirmed the three-stage reaction of hydration, ion exchange, and desorption during Li<sup>+</sup> capture by LFP@C-7. Furthermore, in-situ X-ray diffraction (XRD) demonstrated a reversible phase transition mechanism (FePO<sub>4</sub>→LiFePO<sub>4</sub>→FePO<sub>4</sub>) throughout the Li<sup>+</sup> insertion and extraction cycles. This study provides a new feasible solution for the green synthesis of low-concentration antisite defects LFP.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102781"},"PeriodicalIF":13.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetically-drivable, pH-responsive Fe3O4/ZIF-8 coating on implant for biofilm prevention and treatment 磁性驱动、ph响应的Fe3O4/ZIF-8植入物涂层用于生物膜的预防和治疗

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-30 DOI: 10.1016/j.nantod.2025.102772

Kecheng Quan , Yupu Lu , Ting Zhang , Shuren Wang , Hao Tang , Chunhao Yu , Yongsheng Zhou , Yunsong Liu , Dandan Xia , Yufeng Zheng

{"title":"Magnetically-drivable, pH-responsive Fe3O4/ZIF-8 coating on implant for biofilm prevention and treatment","authors":"Kecheng Quan , Yupu Lu , Ting Zhang , Shuren Wang , Hao Tang , Chunhao Yu , Yongsheng Zhou , Yunsong Liu , Dandan Xia , Yufeng Zheng","doi":"10.1016/j.nantod.2025.102772","DOIUrl":"10.1016/j.nantod.2025.102772","url":null,"abstract":"<div><div>Antimicrobial coatings with the capabilities to prevent and treat biofilm infections on implant are promising surface treatment strategies, but it is difficult to eradicate an already-formed biofilm by the coating. Magnetically-drivable coatings can physically destruct the surface-attached biofilm to enhance antimicrobial killing. However, current magnetic coatings cannot inhibit the initial bacteria growth and the demand of coating stability restricts their magnetic controllability. Herein, a magnetically-drivable, pH-responsive coating is developed by simply mixing Fe<sub>3</sub>O<sub>4</sub> and ZIF-8 nanoparticles on titanium surface. In physiological pH, Fe<sub>3</sub>O<sub>4</sub> nanoparticles are stable and non-magnetically drivable on surface due to charge attractions and electrostatic interactions. While in acidic pH caused by bacterial growth, ZIF-8 degradation is significantly accelerated, releasing Zn<sup>2 +</sup> and recovering the magnetic controllability of Fe<sub>3</sub>O<sub>4</sub> nanoparticles. The released Zn<sup>2+</sup> kills the initially-attached bacteria, inhibiting subsequent biofilm formation. Once a biofilm has formed, Fe<sub>3</sub>O<sub>4</sub> nanoparticles can be magnetically pulled-off to destruct the biofilm structure and then enhance antibiotic killing. The Fe<sub>3</sub>O<sub>4</sub>/ZIF-8 coating shows excellent biocompatibility and osteogenesis to compare with bare Ti disc. Animal experiments further proved the <em>in-vivo</em> antimicrobial and osteogenic performances of the coating. Therefore, this work put forward a new surface strategy to solve biofilm-related infections on implants.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102772"},"PeriodicalIF":13.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A hierarchically programmable DNA nanodevice for spatiotemporally selective imaging of mitochondrial microRNA in cells and animals 用于细胞和动物线粒体microRNA时空选择性成像的分层可编程DNA纳米器件

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-30 DOI: 10.1016/j.nantod.2025.102779

Lie Li , Shuo Xu , Mingxuan Chen , Peifen Lu , Yu Wang , Chang Liu , Jianwei Jiao , Peng Miao , Jin Jiao

{"title":"A hierarchically programmable DNA nanodevice for spatiotemporally selective imaging of mitochondrial microRNA in cells and animals","authors":"Lie Li , Shuo Xu , Mingxuan Chen , Peifen Lu , Yu Wang , Chang Liu , Jianwei Jiao , Peng Miao , Jin Jiao","doi":"10.1016/j.nantod.2025.102779","DOIUrl":"10.1016/j.nantod.2025.102779","url":null,"abstract":"<div><div>DNA nanodevices remain at the forefront of bioimaging efforts within living cells, yet most are constrained by the undesired off-site activation and the insufficient subcellular precision. Herein, we sought to overcome this limitation by developing a hierarchically programmable DNA nanodevice (HPDN) that enables spatiotemporally selective imaging of mitochondrial microRNA (miRNA) with improved detection accuracy. Specifically, the sensing function of HPDN is silent by the elaborate introduction of an abasic site and a photocleavable linker, but can be hierarchically activated by endogenous human apurinic/apyrimidinic endonuclease 1 (APE1) in the cytoplasm and exogenous ultraviolet light after targeted mitochondrial localization, allowing for mitochondria-specific miRNA imaging in cells and animals. It is demonstrated that the HPDN system promises a robust mitochondrial miRNA imaging with reduced off-tumor signal leakage, thus enhancing the tumor-to-background ratio. Moreover, this system is employed for the visualizing the APE1-mediated drug resistance in tumor cells, facilitating the advancement of tumor diagnosis and therapeutic evaluation. Therefore, this work illustrates a comprehensive and powerful biosensing toolbox with great potential for precise biomedical applications.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102779"},"PeriodicalIF":13.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-imaging the inhibition of breast cancer cell migration by maduramicin via surface charge alteration using scanning ion conductance microscopy 利用扫描离子电导显微镜通过表面电荷改变观察马杜拉米霉素对乳腺癌细胞迁移的抑制作用

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-29 DOI: 10.1016/j.nantod.2025.102774

Xinhao Song , Yao Song , Mengjuan Lin , Moran Wang , Tianqi Jia , Juan Jin , Jingjing Sun , Genhua Duan , Xiuge Gao , Shanxiang Jiang , Feng Chen , Ning Gu , Dawei Guo

{"title":"Nano-imaging the inhibition of breast cancer cell migration by maduramicin via surface charge alteration using scanning ion conductance microscopy","authors":"Xinhao Song , Yao Song , Mengjuan Lin , Moran Wang , Tianqi Jia , Juan Jin , Jingjing Sun , Genhua Duan , Xiuge Gao , Shanxiang Jiang , Feng Chen , Ning Gu , Dawei Guo","doi":"10.1016/j.nantod.2025.102774","DOIUrl":"10.1016/j.nantod.2025.102774","url":null,"abstract":"<div><div>Cancer cells possess a negatively charged surface that significantly influences key biological processes, including motility and invasiveness. Understanding the cellular membrane at the nanoscale level, especially in deciphering tumor migration mechanisms, is crucial yet complex. In this study, we explored the impact of maduramicin (MAD), a polyether ionophore antibiotic, on the surface charge distribution in tumor cell membranes. Our findings demonstrated that modulating calcium channels and disrupting charge distributions, imaged by a current difference-based scanning ion conductance microscopy (ΔI-SICM) method, resulted in significant reductions in both cell invasiveness and viability. These results emphasize the cell membrane's considerable role at the nano-bio interface, highlighting the intricate relationship between biophysical properties and cellular behaviors. Our research suggests that targeting the charge distribution of cell membrane may offer a novel therapeutic strategy to mitigate cell migration and enhance treatment outcomes in cancer therapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102774"},"PeriodicalIF":13.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precise delivery of 10B at cellular resolution in vivo enhances boron neutron capture therapy effect 在体内以细胞分辨率精确递送10B提高硼中子捕获治疗效果

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-28 DOI: 10.1016/j.nantod.2025.102773

Linwen Lv , Qiuyang Liu , Wenxi Su , Haojun Liang , Xin Pan , Junhui Zhang , Ranran Chen , Ziteng Chen , Zhijie Wang , Ruyu Yan , Mingxin Yang , Yanan Chang , Juan Li , Gengmei Xing , Kui Chen

{"title":"Precise delivery of 10B at cellular resolution in vivo enhances boron neutron capture therapy effect","authors":"Linwen Lv , Qiuyang Liu , Wenxi Su , Haojun Liang , Xin Pan , Junhui Zhang , Ranran Chen , Ziteng Chen , Zhijie Wang , Ruyu Yan , Mingxin Yang , Yanan Chang , Juan Li , Gengmei Xing , Kui Chen","doi":"10.1016/j.nantod.2025.102773","DOIUrl":"10.1016/j.nantod.2025.102773","url":null,"abstract":"<div><div>Boron neutron capture therapy (BNCT) is a promising binary radiotherapy that uses the isotope <sup>10</sup>B and thermal neutron irradiation to induce lethal nuclear reactions in tumor cells. However, the effectiveness of BNCT often relies on the precise match between <sup>10</sup>B and thermal neutrons. In this study, we developed a boron delivery system, integrating boron nitride (<sup>10</sup>BN) nanoparticles with microneedle (MN) patches (referred to as BN-MN). At equivalent dosages, BN-MN was able to maintain an intratumoral boron concentration above 20 ppm for over two hours, effectively aligning with the neutron irradiation time window. BN-MN also demonstrated efficient penetration and uniform distribution throughout the entire tumor tissue, with a tumor-to-normal tissue ratio (T/N) of 42 and a tumor-to-blood ratio (T/B) of 150, significantly superior to clinical boron drugs. More importantly, BN-MN efficiently delivered boron into tumor tissues at a precise cellular resolution, achieving an intracellular boron concentration 6.8 times higher than that obtained by BPA-loaded microneedles (BPA-MN). In vivo experiments demonstrated that the BN-MN system effectively inhibited tumor growth under neutron irradiation, with minimal systemic side effects. In summary, BN-MN perfectly matched neutron irradiation in terms of sufficient concentration, optimal retention time, and uniform spatial distribution, thereby enhancing the therapeutic efficacy and safety of BNCT.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102773"},"PeriodicalIF":13.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-assembled Gold@silver-ZIF structure-induced dual-enhancement luminescence synergized with interpretable machine learning empower precise monitoring of inflammatory homeostasis 自组装Gold@silver-ZIF结构诱导的双增强发光与可解释的机器学习协同，使炎症稳态的精确监测成为可能

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-26 DOI: 10.1016/j.nantod.2025.102776

Gaoxiang Xu , Mengke Wang , Qing Li , Lianghui Fan , Runpu Shen , Zhikang Xiao , Jianzhong Xu , Kun Wang , Junyang Chen

{"title":"Self-assembled Gold@silver-ZIF structure-induced dual-enhancement luminescence synergized with interpretable machine learning empower precise monitoring of inflammatory homeostasis","authors":"Gaoxiang Xu , Mengke Wang , Qing Li , Lianghui Fan , Runpu Shen , Zhikang Xiao , Jianzhong Xu , Kun Wang , Junyang Chen","doi":"10.1016/j.nantod.2025.102776","DOIUrl":"10.1016/j.nantod.2025.102776","url":null,"abstract":"<div><div>The maintenance of an optimal inflammatory homeostasis within the body is crucial for its sustained viability within a natural environment replete with pathogenic factors. The real-time, precise detection of two antagonistic cytokines (pro- and anti-inflammatory) in an inflammatory state is fundamental to the guidance of precise clinical treatments and thus the achievement of inflammatory homeostasis. Herein, we synthesized AuAg-ZIF, which resulted in a dual enhancement of the fluorescence properties of AuNCs (35-fold increase in fluorescence intensity and 18.5-fold increase in quantum yield) by the anti-galvanic reaction between the surface Ag(I) and core Au (0), as well as by the confinement effect of ZIF-8. Furthermore, a generalized fluorescence immunoassay utilizing liposome-mediated Cu<sup>2 +</sup>-induced fluorescence quenching of AuAg-ZIF has been developed, resulting in amplification of the antigenic signal. Additionally, an interpretable machine learning prediction algorithm was constructed, comprising feature extraction, feature dimensionality reduction, model construction and validation, and model interpretation. This algorithm achieves immediate and accurate detection of factors related to anti-inflammatory, pro-inflammatory, and inflammatory levels in the human inflammatory homeostasis (R<sup>2</sup> > 0.95), which is in line with the accuracy of the current commercial assay kits. This integration of dual-enhanced fluorescent nanoscale materials, amplification strategies, and interpretable machine learning enables the real-time, accurate observation of inflammatory homeostasis, thereby facilitating the delivery of precision clinical treatments.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102776"},"PeriodicalIF":13.2,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0