Nano Today最新文献

{"title":"Puerarin-loaded hyaluronic acid self-assembled nanoparticles ameliorate hyperuricemic nephropathy by modulating lipid peroxidation and macrophage polarization","authors":"Mu-xuan Wang ,&nbsp;Ying-ying Chen ,&nbsp;Shu-tao Sun ,&nbsp;Mohamed A. Farag ,&nbsp;Zhi-yong Zhao ,&nbsp;Shi-hai Lu ,&nbsp;Min-hsiung Pan ,&nbsp;Ning-yang Li ,&nbsp;Xu Guo ,&nbsp;Chao Liu","doi":"10.1016/j.nantod.2026.102983","DOIUrl":"10.1016/j.nantod.2026.102983","url":null,"abstract":"<div><div>Hyperuricemic nephropathy (HUN) is a chronic kidney disease, as featured by the large amount of uric acid (UA) deposited in the kidney. Lipid peroxidation and macrophage infiltration caused by UA are two prominent risk factors linked in the occurrence of HUN. Puerarin (PEA) has anti-hyperuricemia, antioxidant, and anti-inflammatory activity, albeit the poor water solubility and a short half-life limit its application. To improve the bioavailability of PEA, this study prepared PEA-loaded hyaluronic acid (HA) self-assembled nanoparticles (PEA-HA NPs). Release kinetics showed that PEA-HA NPs achieved the pH-responsive sustained-release in the weakly acidic microenvironment of HUN. <em>In vivo</em> biodistribution indicated that PEA-HA NPs was preferably internalized by renal tubular epithelial cells in HUN, which was attributed to the specific binding between HA and CD44 receptor. <em>In vitro</em> health benefits confirmed that PEA-HA NPs modulated lipid peroxidation though a distinctive four-pronged strategy in UA-induced HK-2 cells, including scavenging ROS, restoration of mitochondrial function, regulation of inflammatory pathways, and inhibition of apoapsis. Likewise, PEA-HA NPs could transform the pro-inflammatory macrophages (M1-type) of into anti-inflammatory macrophages (M2-type), thereby inhibiting UA-caused macrophage infiltration. <em>In vivo</em> analysis also showed that PEA-HA NPs could alleviate renal dysfunction and fibrosis by modulating lipid peroxidation and macrophage polarization. This study improves the bioavailability and long-lasting therapeutic duration of PEA, which provides a convenient strategy for the efficient treatment of HUN.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102983"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward climate-resilient and fire-safe buildings: Multifunctional surface materials integrating radiative cooling and flame retardancy","authors":"Xueyi Zhao ,&nbsp;Yu Lei ,&nbsp;Lulu Xu ,&nbsp;Anthony Chun Yin Yuen ,&nbsp;Ying Pan ,&nbsp;Vipul Agarwal ,&nbsp;Yao Yuan ,&nbsp;Wei Cai ,&nbsp;Kate T.Q. Nguyen ,&nbsp;Guan Heng Yeoh ,&nbsp;Wei Wang","doi":"10.1016/j.nantod.2026.102984","DOIUrl":"10.1016/j.nantod.2026.102984","url":null,"abstract":"<div><div>Amid the escalating urban heat island effects and increasing fire hazards driven by climate change and rapid urbanization, buildings face two parallel challenges: excessive heat accumulation and heightened fire vulnerability. Multifunctional surface materials that integrate passive radiative cooling (PRC) and flame retardant (FR) have emerged as promising solutions for enhancing both energy efficiency and fire safety. By synergistically combining PRC and FR functionalities, these materials can reflect solar radiation and emit heat to reduce surface temperatures, while simultaneously inhibiting ignition, slowing flame spread, and suppressing toxic smoke via gas-phase and condensed-phase mechanisms. This review presents a comprehensive overview of their working principles, performance evaluation methods, and material classifications of such materials, focusing on four main systems: organic polymer-based materials, polymer–inorganic composites, bio-based materials, and other material systems. Particular emphasis is placed on the relationship among materials, structure, and properties, strategies for integrating multifunctionality, and the influence of environmental conditions on long-term performance. Key challenges related to climate adaptability, outdoor durability, and filler dispersion are discussed to guide future research. These materials offer a promising pathway toward energy-efficient, fire-safe, and climate-resilient buildings.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102984"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Nanoparticle-inhibited neutrophil elastase prevents neutrophil extracellular trap and alleviates rheumatoid arthritis in C57BL/6 mice” [Nano Today 50 (2023) 101880]","authors":"Min Liu,&nbsp;Siyi Liu,&nbsp;Lin Liu,&nbsp;Jingya Xiu,&nbsp;Tian Zhang,&nbsp;Dawei Chen,&nbsp;Mingxi Qiao,&nbsp;Haiyang Hu,&nbsp;Jiulong Zhang,&nbsp;Xiuli Zhao","doi":"10.1016/j.nantod.2025.102919","DOIUrl":"10.1016/j.nantod.2025.102919","url":null,"abstract":"","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102919"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Real-time ROS monitoring-guided tumor electrodynamic therapy using a metal microneedle array system” [Nano Today 63 (2025) 102731]","authors":"Xiaoxue Xie ,&nbsp;Jing Liu ,&nbsp;Zhengjie Liu ,&nbsp;Huiye Wei ,&nbsp;Minzhao Lin ,&nbsp;Gengjia Chen ,&nbsp;Zhibo Liu ,&nbsp;Mengyi He ,&nbsp;Xinshuo Huang ,&nbsp;Shuang Huang ,&nbsp;Yunuo Wang ,&nbsp;Ji Wang ,&nbsp;Huijiuan Chen ,&nbsp;Qi Chen ,&nbsp;Xi Xie ,&nbsp;Xintao Shuai","doi":"10.1016/j.nantod.2025.102933","DOIUrl":"10.1016/j.nantod.2025.102933","url":null,"abstract":"","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102933"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights into therapeutic strategies against Zika virus from virus–host interactions","authors":"Qiqi Li ,&nbsp;Yuhan Dong ,&nbsp;Zehong Chen ,&nbsp;Hui Zhang ,&nbsp;Zengming Wang ,&nbsp;Nan Liu ,&nbsp;Mei Lu ,&nbsp;Wei Zhu ,&nbsp;Haonan Xing ,&nbsp;Aiping Zheng","doi":"10.1016/j.nantod.2025.102902","DOIUrl":"10.1016/j.nantod.2025.102902","url":null,"abstract":"<div><div>Global climate change has created favorable conditions for the transmission and expansion of the Zika virus (ZIKV), with the risk of ZIKV re-emergence posing an ongoing biosecurity threat. However, the lack of effective anti-Zika drugs makes the clinical application of symptom-relieving therapies the only available option. Recent progress in understanding virus–host interactions has significantly accelerated the development of innovative antiviral strategies against ZIKV infection. This review examines the challenges encountered in the development of anti-ZIKV drugs and explores potential therapeutic strategies through a novel ZIKV–host interaction perspective. Moreover, this review systematically outlines novel anti-ZIKV drug strategies, including promising molecular mechanisms and potential targets derived from ZIKV, replication-associated host factors, and immune system elements for drug design. Targeting ZIKV structural components to disrupt its life cycle remains a conventional antiviral strategy, while targeting replication-associated host factors and developing drugs that modulate host cellular processes represent promising therapeutic approaches. The frequently neglected antagonistic effect of ZIKV on innate host immunity and corresponding antiviral strategies are also examined in this review. More importantly, recent progress in antiviral strategies during pregnancy and anti-ZIKV drug delivery strategies are examined, with a focus on potential challenges and future directions for anti-Zika drugs. Further, regulating key placental blood barrier targets represents a promising therapeutic strategy against ZIKV during pregnancy. The progress of anti-ZIKV drug delivery systems enable maximum therapeutic efficacy. This review proposes an integration of potential intervention strategies from the perspective of ZIKV–host interactions, thereby aiming to establish a foundation for future anti-ZIKV research while accelerating the translation of anti-ZIKV therapeutics into clinical practice.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102902"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing role of magnetic field-guided MnFe2O4@ZIF-8@retinoic acid in DUCA conduits for inflammation inhibition and peripheral nerve regeneration","authors":"Majid Sharifi ,&nbsp;Majid Salehi ,&nbsp;Somayeh Ebrahimi-Barough ,&nbsp;Mohammad Kamalabadi-Farahani","doi":"10.1016/j.nantod.2025.102910","DOIUrl":"10.1016/j.nantod.2025.102910","url":null,"abstract":"<div><div>Neuroma formation following the repair of nerve injuries exceeding 0.9 cm in length severely impedes functional recovery. To overcome this challenge, we engineered magnetically responsive core-shell nanoparticles (MnFe₂O₄@ZIF-8@Retinoic acid, MFZR; 90–360 nm) to guide regeneration within a decellularized umbilical cord artery (DUCA) conduit. We investigated the synergistic effect of MFZR under an external magnetic field (MF) on Schwann cell behavior in vitro and on sciatic nerve repair in a rat model. Under MF exposure, MFZR significantly enhanced Schwann cell migration, alignment, and elongation on DUCA conduits. <em>In-vivo</em>, the MFZR+MF combination potently promoted functional recovery, as measured by the sciatic functional index, muscle compound action potential, and nerve conduction velocity, without inducing DUCA-related inflammation. Histological analysis demonstrated robust regeneration, characterized by increased axon diameter, an improved G-ratio, and elevated expression of S100 and NF-200. This regeneration was facilitated by a healing-promoting M2 macrophage polarization at the injury site. Critically, the strategy exhibited no systemic toxicity. These findings establish that magnetically guided MFZR effectively prevents neuroma in the DUCA conduits, orchestrates a pro-regenerative microenvironment, and achieves significant functional recovery, offering a promising translatable strategy for nerve repair.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102910"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated DNA logic gate-driven cell membrane confined amplification system for imaging cellular events","authors":"Zhenzhen Guo ,&nbsp;Yue Qiu ,&nbsp;Yang Wang ,&nbsp;Jiali Zhang ,&nbsp;Xiaotong Jiang ,&nbsp;Danyu Wang ,&nbsp;Hua Yi ,&nbsp;Mengyu Huang ,&nbsp;Peiru Chen ,&nbsp;Fangmei Zhang ,&nbsp;Yan Liang ,&nbsp;Fengming Chen ,&nbsp;Hua Gao ,&nbsp;Qiuxia Yang ,&nbsp;Kaixiang Zhang","doi":"10.1016/j.nantod.2025.102934","DOIUrl":"10.1016/j.nantod.2025.102934","url":null,"abstract":"<div><div>The spatiotemporal profiling of membrane-localized biomarkers of cellular events is pivotal for unraveling disease pathogenesis and advancing precision medicine. However, the current inefficient multi-target discrimination, due to the limited computational capacity of monovalent logic elements and diffusion-limited signal amplification strategies, has hindered its advancement. Here, we present an innovative platform that enables integrated DNA logic gate-driven, spatially confined signal amplification at membrane interfaces. In the design, by encoding traditional monovalent DNA logic units into multivalent tandem architectures, we developed next-generation integrated DNA logic gate elements (iLGE), enabling parallel Boolean operations on multiple biomarkers with threefold enhanced computation efficiency and reduced spatial dependency. Additionally, embedding DNAzyme-mediated signal switches and substrates within a multivalent amphiphilic DNA scaffold enabled the engineering of a DNA walker device (DWD) that stably anchors to the cell membrane, facilitating a dual spatially confined signal amplification strategy. This platform possesses high sensitivity and precision in detecting localized nucleic acids, proteins, and specific cells at the engineered cell membrane interface, thereby enabling precise capture and analysis of events, including cell damage, cellular oncogenesis, and interactions between NK cells and tumor cells. It offers a new, comprehensive diagnostic and analytical platform for exploring membrane-localized events and their related disease mechanisms.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102934"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A glucose-activated cascade oxygen release hydrogel wound dressing for microenvironment regulation of MRSA-infected diabetic wounds","authors":"Huiru Xu ,&nbsp;Xin Zhao ,&nbsp;Jiaxin Wang ,&nbsp;Yutong Yang ,&nbsp;Shengfei Huang ,&nbsp;Meng Li ,&nbsp;Baolin Guo","doi":"10.1016/j.nantod.2025.102962","DOIUrl":"10.1016/j.nantod.2025.102962","url":null,"abstract":"<div><div>Diabetic wounds are faced with a severe microenvironment of hyperglycemia, excessive ROS, and hypoxia. Developing targeted diabetic wound dressings that can improve this microenvironment to achieve efficient wound healing is highly anticipated. Here, a glucose-activated oxygen-release hydrogel loaded with cascaded nanozymes is designed to regulate wound microenvironment and promote MRSA-infected diabetic wound healing. Specifically, GOx@Zn-MOF-74 and MnO₂ are loaded into a hydrogel (HP-LT/G/M) formed by phenyl borate-grafted hyaluronic acid (HP) and 3,4,5-trihydroxybenzoic acid-grafted lysozyme (LT) via phenyl borate-ester bonds. In response to the hyperglycemia and excessive ROS wound microenvironment, the hydrogel releases these two nanozymes. GOx@Zn-MOF-74 can oxidize glucose into gluconic acid and H₂O₂ under the action of O₂, while MnO₂ converts endogenous and generated H₂O₂ into O₂. The cascade reaction can provide oxygen for subsequent glucose oxidation, accelerate the reaction process, improve wound hypoxia, consume glucose, and scavenge excessive ROS. In MRSA-infected full-skin defect model of diabetic mice, HP-LT/G/M hydrogel significantly accelerated wound closure, reduced inflammation, alleviated hypoxia, and promoted collagen deposition and angiogenesis. In summary, the glucose-activated oxygen release hydrogel with nanozyme cascade reaction responds to the wound microenvironment to achieve glucose decomposition, ROS scavenge, and oxygen release, showing great potential in diabetic wound management.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102962"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MgFe-LDH-doped GelMA hydrogel scaffold repaired spinal cord injury via immunoregulation and enhancement of neuronal differentiation","authors":"Shasha Zheng ,&nbsp;Ruiqi Huang ,&nbsp;Xugang Zhuang ,&nbsp;Qian Zhu ,&nbsp;Qingyue Cui ,&nbsp;Hong Cheng ,&nbsp;Wenyu Liang ,&nbsp;Chenyu Du ,&nbsp;Jing Li ,&nbsp;Bin Zhang ,&nbsp;Xin Gao ,&nbsp;Yusong Wang ,&nbsp;Pan Feng ,&nbsp;Lei Tian ,&nbsp;Yangnan Hu ,&nbsp;Zuhong He ,&nbsp;Rongrong Zhu ,&nbsp;Renjie Chai","doi":"10.1016/j.nantod.2025.102944","DOIUrl":"10.1016/j.nantod.2025.102944","url":null,"abstract":"<div><div>Spinal cord injury (SCI) is a traumatic condition of the nervous system that leads to severe disability. Its poor prognosis is largely attributed to uncontrolled inflammation and the intrinsically limited regenerative capacity of the spinal cord, which together severely restrict functional recovery. Hydrogel-based scaffolds represent a prospective strategy for SCI repair, offering structural support and a conducive microenvironment for regeneration. Here, we developed a gelatin methacrylate (GM) hydrogel scaffold incorporating MgFe-layered double hydroxide (LDH) nanoparticles functionalized with brain-derived neurotrophic factor (BDNF). This multifunctional GM-BDNF-LDH scaffold enables sustained release of BDNF, which promotes neuronal survival and regeneration, while LDH contributes additional therapeutic benefits through immunomodulation and neurogenic support. In both <em>in vivo</em> and <em>in vitro</em> experiments, LDH promoted the differentiation of neural stem cells (NSCs) while suppressing the expression of M1 markers and promoting the expression of M2 markers in microglia. Furthermore, the functional scaffold significantly improved motor function restoration, inflammation suppression, and neural differentiation in rats. Together, these results demonstrate that the LDH-functionalized scaffold we proposed can simultaneously modulate the immune microenvironment and promote neuronal regeneration, offering a potential treatment strategy for SCI recovery.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102944"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannosylated siRNA/PERKi nanoassemblies reprogram macrophages to block tumor metastasis","authors":"Junjie Ren ,&nbsp;Shiyin Zhao ,&nbsp;Dali Wang ,&nbsp;Yao Wang ,&nbsp;Wei Huang ,&nbsp;Feng Zhu ,&nbsp;Lijuan Zhu ,&nbsp;Deyue Yan","doi":"10.1016/j.nantod.2026.102975","DOIUrl":"10.1016/j.nantod.2026.102975","url":null,"abstract":"<div><div>Tumor-associated macrophages (TAMs) are pivotal mediators of the immunosuppressive tumor microenvironment (TME), promoting immune evasion and tumor progression. Current TAM-targeted therapies, which aim to repolarize immunosuppressive M2-polarized TAMs into tumoricidal M1 phenotype, face limitations due to the complex immunosuppressive networks within the TME. To address this challenge, we developed a mannosylated nanodrug for TAM targeting through the co-assembly of an inhibitor of protein kinase RNA-like endoplasmic reticulum kinase (PERKi) and mannoseylated PD-L1 siRNA (Man-siPDL1). This dual-targeting nanodrug simultaneously disrupts PERK-mediated immunosuppression and PD-L1 checkpoint signaling, effectively inducing M2-to-M1 repolarization and enhancing cytotoxic T lymphocytes (CTLs) infiltration. In Hepa1–6 tumor models, the mannosylated nanodrug demonstrated superior tumor targeting and TME remodelling, evidenced by an increased M1/M2 TAM ratio, elevated CTLs populations, superior PD-L1 downregulation, and enhanced immunostimulatory cytokine expression. This strategy not only overcomes key immunosuppressive barriers in solid tumors but also provides a versatile platform for RNAi-based immunotherapy, with potential applications across diverse cancer types.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102975"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145972871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}