Nano Today最新文献

{"title":"Photoactivatable MoSx/γ-MnS nanocomposite as redox dyshomeostasis amplifier for polysulfide-intensive chemodynamic cancer therapy","authors":"Yanlong Wang ,&nbsp;Jie Yu ,&nbsp;Hongfei Su ,&nbsp;Zejin Ju ,&nbsp;Jun Chen ,&nbsp;Qiang Wang ,&nbsp;Longgang Wang ,&nbsp;Na Peng ,&nbsp;Lizeng Gao ,&nbsp;Yuliang Zhao ,&nbsp;Wenyan Yin","doi":"10.1016/j.nantod.2024.102609","DOIUrl":"10.1016/j.nantod.2024.102609","url":null,"abstract":"<div><div>Redox homeostasis is a key reason for reactive oxygen species (ROS) tolerance in tumors. Complex reactive species interactome is closely related to the limited effectiveness of ROS-mediated cancer therapy. Engineering redox dyshomeostasis amplifier by disturbing the interactome of ROS with reactive sulfur species (RSS) remains a great challenge. Herein, a gelatin/cRGD–modified redox dyshomeostasis amplifier based on MoS_x/γ-MnS (MMS) hollow nanoflowers polysulfide nanocomposite was constructed by a one-pot solvothermal process for an elevated intracellular ROS level through near-infrared (NIR)-II light–activated cancer-specific polysulfide-intensive chemodynamic therapy (CDT). The NIR-II light accelerated H₂S-H₂S_2–3 (typical RSS) release in acidic tumor microenvironment (TME). Density functional theory calculations divulged that overexpressed H₂O₂ in acidic TME can augment the release of H₂S–H₂S_2–3, triggered by low activation energy of the MMS, consequently depleting glutathione (GSH) level. The form and quantity of H₂S–H₂S_2–3 can be analyzed by the advanced technology of in-situ synchrotron radiation (SR) X-ray absorption near-edge structure spectrum combined with high-performance liquid chromatograph-mass spectrometer. Simultaneously, Mn^2 +-releasing CDT efficiency was enhanced to produce hydroxyl radicals (·OH), breaking redox homeostasis to induce ROS accumulation in the TME. Then, the ROS amplified oxidative stress damage through synchronous ferroptosis–apoptosis, potentially eradicating tumor without metastasis.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102609"},"PeriodicalIF":13.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent fiber-based sensors for continuous monitoring of levodopa concentration and real-time Parkinson management","authors":"Da-Wei Zhou ,&nbsp;Meng Yin ,&nbsp;Chen-Yu Wang ,&nbsp;Xiao-Xue Wang ,&nbsp;Yan-Li Li ,&nbsp;Yun Shen ,&nbsp;Qi Fang ,&nbsp;Ke-Zheng Chen ,&nbsp;Sheng-Lin Qiao","doi":"10.1016/j.nantod.2024.102613","DOIUrl":"10.1016/j.nantod.2024.102613","url":null,"abstract":"<div><div>Current Parkinson's disease (PD) management often fails to account for the complex relationship between fluctuating drug levels and symptom variability. Here, fiber-based biochemical and biomechanical sensors have been engineered for continuous monitoring of levodopa levels and motor symptoms. These biochemical sensors exhibit remarkable selectivity and sensitivity towards levodopa, with a linear detection range spanning from 1 µM to 250 µM and a detection limit as low as 0.13 µM. This high-performance detection capability allows for real-time, non-invasive therapeutic drug monitoring, offering insights into disease progression and patient response. Furthermore, triboelectric nanogenerator sensors are integrated to track subtle motor symptoms, such as tremors, complementing the biochemical data. This dual approach provides a comprehensive assessment of PD, enabling personalized treatment strategies by continuously evaluating both drug levels and symptom fluctuations. The combination of these technologies represents a significant advancement in PD management, offering real-time insights that inform pharmacotherapy adjustments and clinical decisions.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102613"},"PeriodicalIF":13.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuned amphiphilic assembly in water for 100 % [2 + 2] photocycloaddition and highly efficient isomeric separation","authors":"Yanyu Zhao ,&nbsp;Xiaodie Zhang ,&nbsp;Hongyu Dai ,&nbsp;Tao Wang ,&nbsp;Weijiang Guan ,&nbsp;Peifa Wei","doi":"10.1016/j.nantod.2024.102619","DOIUrl":"10.1016/j.nantod.2024.102619","url":null,"abstract":"<div><div>Photoresponsive smart materials suffer from elusive reaction pathways and complicated purification processes, which contradicts the principles of green chemistry and atomic economy chemistry. Herein, based on simply tuned self- and co-assembly of an amphiphile in water, a \"one stone, two birds\" function is achieved in a controllable photoresponsive system, that is quantitative photocycloaddition and efficient <em>E</em>/<em>Z</em> isomeric separation. Self-assembly driven by hydrophobicity refines the photochemical process to a single pathway with remarkable 100 % conversion. The synergy of thermal responsiveness and ion-induced co-assembly enables selective crystallization, facilitating highly efficient <em>E/Z</em> isomeric separation. This study demonstrates the host-guest interactions between open linear oligoethylene glycol chains and cations by single crystal. The tunable transparency and the inherent aggregated emission allow for visible tracking of both the photocycloaddition and separation processes, providing valuable insights into the underlying mechanisms. This work offers a new paradigm for the development of green and controllable photoresponsive systems.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102619"},"PeriodicalIF":13.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visually invisible multimode anti-counterfeiting based on highly transparent superamphiphobic/superhydrophilic pattern","authors":"Qingqing Jin ,&nbsp;Haojun Li ,&nbsp;Yue He ,&nbsp;Yu Wang ,&nbsp;Yang Chai ,&nbsp;Yudong Li ,&nbsp;Xizhe Huang ,&nbsp;Haibo Li ,&nbsp;Shuoran Chen ,&nbsp;Yanan Li ,&nbsp;Zuankai Wang ,&nbsp;Mingmei Wu","doi":"10.1016/j.nantod.2024.102621","DOIUrl":"10.1016/j.nantod.2024.102621","url":null,"abstract":"<div><div>Anti-counterfeiting technology can identify the authenticity of products, which plays an increasingly important role in combating piracy and protecting intellectual property. For optical products or devices, such as optical lens, glasses, screens and photovoltaic components, optical transparency and visual invisibility are highly necessary for the applied anti-counterfeiting technology. Herein, a visually invisible multimode anti-counterfeiting material was designed by constructing highly transparent superamphiphobic/superhydrophilic wetting pattern. The anti-counterfeiting pattern was invisible under normal conditions due to the high transparency of the wetting pattern, which enables the camouflage advantages of the anti-counterfeiting pattern. While under the treatment of fog by steam or halitus, the pattern can become visible in seconds due to the transmittance difference between the superamphiphobic and superhydrophilic area, owing to the distinct light scattering behavior between liquid droplets on the superamphiphobic area and liquid film on the superhydrophilic area. The excellent lyophobicity of the superamphiphobic area and its distinct surface energy gap to the superhydrophilic areas endow excellent pattern stability and robust in practical applications. With additional invisible fluorescent molecules on the superhydrophilic area, the multimode anti-counterfeiting pattern also becomes visible under ultraviolet light, which can further improve the security of the anti-counterfeiting pattern. Owing to the visual camouflage, simple writing/reading procedure and function expansibility, we believe that this transparent wetting pattern based visually invisible multimode anti-counterfeiting material will be attractive for the areas of optical surfaces and devices.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102621"},"PeriodicalIF":13.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extreme environment-resistant high performance triboelectric nanogenerator for energy harvesting and self-powered positioning system","authors":"Yangjiu Zhao ,&nbsp;Haoran Yu ,&nbsp;Ruirui Cao ,&nbsp;Ying Liu ,&nbsp;Shaowei Shen ,&nbsp;Xin Li ,&nbsp;Haoyi Wu ,&nbsp;Dequan Sun ,&nbsp;Haihui Liu ,&nbsp;Caofeng Pan","doi":"10.1016/j.nantod.2024.102616","DOIUrl":"10.1016/j.nantod.2024.102616","url":null,"abstract":"<div><div>Ensuring the effectiveness of triboelectric devices under extreme environmental temperatures is essential for the global implementation of TENG-driven self-powered electronics in various regions worldwide, but achieving this is substantial challenging. In this work, a thermally stable and flexible PVDF-HFP/SEBS (PH_SS_O) composite membrane doped with stearic acid (SA) and octanoic acid (OA) is constructed by the method of electrostatic spraying-assisted electrospinning. Compared with the original PHS membrane, the PH_SS_O membrane not only exhibits enhanced triboelectric output (<em>V</em>_<em>oc</em>, <em>I</em>_<em>sc</em>, and <em>Q</em>_<em>sc</em> increased by 61.48 %, 77.11 %, and 46.16 % respectively), but also maintains a relatively stable triboelectric output from room temperature to a high-temperature environment of 60°C, highlighting its remarkable reliability and stable power supply capability. Furthermore, the fabricated PH_S1.5S_O1.5 triboelectric membrane exhibits outstanding hydrophobicity, flexibility, stretchability, and cyclic stability. These qualities render PH_S1.5S_O1.5 based TENG to be an appealing self-powered positioning device, offering critical data such as time and location to adventurers and scientists operating in extreme Earth environments, thereby ensuring their safety. In summary, this study has developed a triboelectronegative fibrous membrane materials with excellent overall performance, which to some extent ensures the effective operation of TENG-driven self-powered devices in extreme temperature environments, providing good feasibility and successful case for applications in energy harvesting and human-machine interaction fields under harsh environments.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102616"},"PeriodicalIF":13.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing wearable nature-skin-derived materials encompassing fireproofing, intelligent early fire-detection, and health-management functionalities","authors":"Xinhua Liu ,&nbsp;Fengqian Yang ,&nbsp;Lijuan Chen ,&nbsp;Qian Zhang ,&nbsp;Jiamin Zhang ,&nbsp;Suqiu Zhao ,&nbsp;Guodong Liu ,&nbsp;Huie Jiang","doi":"10.1016/j.nantod.2024.102622","DOIUrl":"10.1016/j.nantod.2024.102622","url":null,"abstract":"<div><div>The incidence of global fires has been steadily increasing, driven by factors such as climate conditions, geographical features, and human activities. To address this challenge, next-generation wearable firefighting fabrics are developed to provide essential fireproofing properties while ensuring wearer comfort, enabling real-time healthcare monitoring, and facilitating early fire-detection for enhanced safety and survival in fire incidents. Herein, a versatile smart nature-skin-derived wearable firefighting fabric (MA-skin) with robustly-integrated functionalities of fireproofing origins, healthcare monitoring, and rapid early-fire-alarming was nano-engineered through straightforward interfacial interactions of the functional building-blocks of MXene and ammonium polyphosphate (APP) and basal skin collagen-fibers. The resulting MA-skin demonstrates exceptional comfort, lightweight properties, biodegradability, and mechanical strength, with measured tensile strength of 9.4 MPa. Importantly, MA-skin shows gratifying flame retardant properties, ultra-fast fire detection (∼1 s), and prolonged alarm duration (&gt;180 s). expectedly, promising to provide effectively desired rapid fire-alarming. Furthermore, MA-skin could subtly convert motion signals into electrical-signal output stably and uninterruptedly as a precise resistive strain-sensor for real-time healthcare monitoring. The integration of MA-skin into firefighting suits enables continuous monitoring of firefighter movement and health status. This study introduces innovative approaches in the development of firefighting fabrics, encompassing fireproofing, intelligent fire detection, and health management functionalities.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102622"},"PeriodicalIF":13.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruption of self-protection pathways enables endogenous copper-evoked cuproptosis via bioorthogonal nanoblocker","authors":"Jiawei Zhu ,&nbsp;Wenting Zhang ,&nbsp;Yawen You ,&nbsp;Minhao Jiang ,&nbsp;Fang Pu ,&nbsp;Jinsong Ren ,&nbsp;Xiaogang Qu","doi":"10.1016/j.nantod.2024.102608","DOIUrl":"10.1016/j.nantod.2024.102608","url":null,"abstract":"<div><div>Cuproptosis, a novel form of copper-dependent cell death, exhibits broad prospects in cancer therapy. However, the application of cuproptosis-based tumor therapy still remains challenging due to the inherent self-protection mechanisms of tumor cells, including copper efflux mediated by copper-transporting proteins and copper-induced protective autophagy. Herein, we construct a safe and efficient bioorthogonal nanoblocker, which can disrupt the self-protection pathways to enable endogenous copper-evoked cuproptosis. The gene silencing-mediated blockage of copper efflux leads to the accumulation of endogenous copper, thereby inducing mitochondrial protein aggregation to efficiently trigger cuproptosis. Meanwhile, the bioorthogonal synthesis of an autophagy inhibitor blocks the resistance of cancer cells to copper overload-mediated cuproptosis. The combination of endogenous copper accumulation and tumor self-protection destruction leads to the death of tumor cells with minimal side effects, thereby achieving a safe and effective cuproptosis-based cancer treatment. This work offers a new avenue for developing cuproptosis-based therapeutic strategies by using endogenous copper and overcoming intrinsic self-protection pathways.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102608"},"PeriodicalIF":13.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Super-resolution fluorescence microscopy and cryogenic soft X-ray tomography enable intracellular localization of stable nanoparticles","authors":"Iris R.S. Ribeiro ,&nbsp;Maria Harkiolaki ,&nbsp;Tomás S. Plivelic ,&nbsp;Leandro R.S. Barbosa","doi":"10.1016/j.nantod.2024.102599","DOIUrl":"10.1016/j.nantod.2024.102599","url":null,"abstract":"<div><div>Cubosomes have emerged as a powerful platform for cancer treatment due to their biocompatibility and ability to encapsulate hydrophilic/lipophilic drugs, providing controlled drug release. While investigating these nanoparticles' stability and intracellular localization is essential for advancing them as clinically efficient nanomedicine, such studies are still lacking, and those available do not provide a reliable and comprehensive understanding. Here, we analyze cubosomes stability in complex media and conduct a pioneering study on visualizing their intracellular localization using a combination of correlative high-resolution three-dimensional fluorescence microscopy and soft X-ray tomography (synchrotron-based technique) at cryogenic temperatures, leveraging natural cellular contrast. Our studies revealed that cubosomes were stable in complex media, confirming their localization within lysosomes. In addition to being crucial for ensuring the advancement of cubosomes for therapeutic purposes, this study paves the way for defining the intracellular localization of other nanoparticles in greater detail, utilizing synchrotron-based 3D imaging techniques. Finally, we confirm the efficacy of doxorubicin-incorporated cubosomes against breast cancer cells.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102599"},"PeriodicalIF":13.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiologically compatible MWCNT-incorporated PNCPG self-healed ionic breathable hydrogel for wearable smart strain sensor application","authors":"Animesh Sinha ,&nbsp;Doheon Koo ,&nbsp;Junho Kim ,&nbsp;Hongyun So","doi":"10.1016/j.nantod.2024.102606","DOIUrl":"10.1016/j.nantod.2024.102606","url":null,"abstract":"<div><div>The demand for wearable and flexible strain gauges is gradually increasing owing to their ease of integration with the human body. However, despite technological advancements, these sensors face challenges such as environmental factors, durability concerns, and calibration difficulties. Hydrogels are semi-solids, contain more water than metals or polymers, and are known for their viscoelasticity, ionic conductivity, and shapeability. One of the drawbacks of hydrogel-based sensors is the reduction in conductivity owing to faster dehydration. Herein, we introduce a material combination of poly (vinyl alcohol) (PVA)/NaCl/carbon nanotube (CNT)/polyethylene glycol (PEG)/glycerol (PNCPG) to synthesize an ionic hydrogel that improves electromechanical properties and reduces the pores present in the hydrogel structure. The ionic hydrogel exhibited self-healing properties, allowing the strain sensor to be reused even after tampering. Furthermore, the relative alteration in resistance demonstrated remarkable consistency and dependability when subjected to cyclic strain conditions for successful real-time human motion detection in addition to smart, wearable, flexible strain sensors. The hydrogel exhibited excellent sensitivity to mechanical deformation; as a result, exceptionally efficient stretchy ionic-hydrogel strain sensors offer substantial opportunities for use in flexible human health motions, soft robotics applications, and wearable electronics.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102606"},"PeriodicalIF":13.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering mucus-penetrating and enzyme-responsive nanostructured carriers for precision targeting of curcumin's pharmacokinetics and colitis-alleviating pathways","authors":"Wenni Tian ,&nbsp;Yuan Li ,&nbsp;Mingzhen Zhang ,&nbsp;Hang Xiao ,&nbsp;Ye Peng ,&nbsp;Mingyue Song ,&nbsp;Yong Cao ,&nbsp;Jie Xiao","doi":"10.1016/j.nantod.2024.102602","DOIUrl":"10.1016/j.nantod.2024.102602","url":null,"abstract":"<div><div>The development of advanced delivery systems that precisely control the absorption, metabolism, and therapeutic efficacy of bioactive compounds is a burgeoning area in nanomedicine. This study introduced an innovative strategy for modulating the pharmacokinetics and therapeutic pathways of curcumin through engineered mucus-penetrating nanostructured lipid carriers (CUR-NLC) and colon-targeted microparticles (CUR-MC). These nanocarriers are designed with hierarchical structures and enzyme-responsive materials to achieve site-specific drug delivery. CUR-NLCs demonstrated superior adhesion and penetration through the ileal mucosa, facilitating curcumin metabolism via host enzymes, while CUR-MCs enhanced colonic targeting, enabling enzyme-responsive curcumin release at inflamed lesion and promoting microbiota-mediated metabolism. In this vein, CUR-NLC achieved the highest peak concentration C_{<strong>max</strong>(<em>CUR</em>)} and absorption rate (K_{<strong>a</strong>}) for curcumin, while CUR-MC improved hepatoenteral circulation and optimized the oral bioavailability and plasma concentrations of its active metabolite tetrahydrocurcumin (THC). Western-blot analysis revealed that CUR-NLC facilitated anti-colitis effect by suppressing inflammatory response through the NF-κB/TLR₄ pathway. Furthermore, our research uncovered a positive correlation between the mucoadhesive efficiency of nanocarriers and their cellular uptake by macrophages. Notably, CUR-MCs demonstrated an increase in colon mucoadhesive capacity (18.35 folds) and macrophage internalization efficiency (28.74 folds) at the colonic mucosa, triggering a superior restoration effect on colonic mucosal inflammation. CUR-MC mitigated colitis by repairing the epithelial physical barrier and enhancing colonic mucosal immunity through the promotion of goblet cell proliferation and the production of occludin and mucin 2. This work highlights the potential of precisely engineered nanostructured carriers in facilitating drug adhesion and permeability efficiency across intestinal mucosa, extending pharmacokinetics of host-microbiome mediated metabolism and enhancing therapeutic efficacy, contributing to the development of site-specific drug delivery techniques in nanomedicine.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102602"},"PeriodicalIF":13.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}