Nano Today最新文献_第5页

Single-molecule light-scattering imaging for in situ counting circular RNA 单分子光散射成像原位计数环状RNA

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102743

Hao Wang , Xin Liu , Pengbo Zhang , Ke Qin , Shen Ling , Xiaoyu Wang , Fangfang Wang , Zhengping Li

{"title":"Single-molecule light-scattering imaging for in situ counting circular RNA","authors":"Hao Wang , Xin Liu , Pengbo Zhang , Ke Qin , Shen Ling , Xiaoyu Wang , Fangfang Wang , Zhengping Li","doi":"10.1016/j.nantod.2025.102743","DOIUrl":"10.1016/j.nantod.2025.102743","url":null,"abstract":"<div><div>The detection of circular RNA (circRNA) at the single-molecule level is essential for the elucidation of circRNA-mediated signaling pathways and its association with disease. Although many fluorescence-based methods have been used for the <em>in situ</em> imaging of circRNA, the inherent defects of fluorescent dyes, including high background signal and photobleaching, preclude sensitivity to the single-molecule level. Herein, leveraging the microRNA sponge feature of circRNA and the strong light-scattering signals of gold nanoparticles (AuNPs), we develop a circRNA-induced assembling of plasmon-coupled spherical nucleic acids (SNAs) strategy for in situ light-scattering imaging and counting of circRNA at the single-molecule level. The SNAs were constructed by modifying sponge probes on AuNPs, which were small and initially invisible. The microRNA sponge nature of circRNA led to the assembly of SNAs to form AuNP aggregates with enhanced light-scattering signals, which could be visualized as diffraction-limited spots irrespective of the interference signals produced by the intracellular environment. This method enabled the accurate quantification of the circRNA by counting the number of spots from a zero background, facilitating the <em>in situ</em> imaging and counting of individual circRNAs at the single-molecule level.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102743"},"PeriodicalIF":13.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphology-driven UV photodetection in self-powered Pt/ZnO Schottky devices 自供电Pt/ZnO肖特基器件中形貌驱动的紫外光探测

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102754

Xiaohu Chen , Binesh Puthen Veettil , Noushin Nasiri

{"title":"Morphology-driven UV photodetection in self-powered Pt/ZnO Schottky devices","authors":"Xiaohu Chen , Binesh Puthen Veettil , Noushin Nasiri","doi":"10.1016/j.nantod.2025.102754","DOIUrl":"10.1016/j.nantod.2025.102754","url":null,"abstract":"<div><div>Emerging nanostructured materials have opened new frontiers in the design of high-performance optoelectronic devices, particularly for self-powered photodetection applications. Here, we present the novel self-powered UV photodetection capabilities of Pt/ZnO Schottky barrier devices that fabricated with two distinct ZnO morphologies: dendrite-like nanoclusters (DNCs) and nano- micro-cluster arrays (NMCAs). Both architectures demonstrate robust self-powered UV photodetection performance, albeit with significant differences in their optoelectronic behavior. The DNC-based UV photodetector (Pt/ZnO<sub>DNCs</sub>), characterized by weak inter-nanoparticle connections and smaller structural dimensions, exhibits reduced photocurrent, higher noise levels, and non-linear photoresponse dynamics under elevated UV illumination. Conversely, the NMCA-based devices (Pt/ZnO<sub>NMCAs</sub>), formed through capillary-driven self-assembly of DNCs using a single ethanol droplet, achieve a dramatic enhancement in performance, with a nearly thousand-fold increase in photocurrent, alongside excellent repeatability and long-term stability. Furthermore, the Pt/ZnO<sub>NMCAs</sub> exhibit a 3.5-fold improvement in response time, with a rise time of 9.6 s compared to 51.9 s for the DNC-based variant under a UV light intensity of 2.5 mW·cm<sup>-</sup>² in self-powered mode. These findings underscore the significant potential of NMCA-structured ZnO nanomaterials as high-performance candidates for photoconductive devices, advancing the development of self-powered optoelectronic technologies.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102754"},"PeriodicalIF":13.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of signaling pathways by metal and metal-doped nanozymes in inflammatory bowel disease: A therapeutic perspective 炎症性肠病中金属和金属掺杂纳米酶的信号通路调控：治疗角度

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102747

Mydhili Govindarasu , Jomon George Joy , Garima Sharma , Jin-Chul Kim

{"title":"Regulation of signaling pathways by metal and metal-doped nanozymes in inflammatory bowel disease: A therapeutic perspective","authors":"Mydhili Govindarasu , Jomon George Joy , Garima Sharma , Jin-Chul Kim","doi":"10.1016/j.nantod.2025.102747","DOIUrl":"10.1016/j.nantod.2025.102747","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD) is a chronic condition driven by oxidative stress and dysregulated immune responses. Key pathways like nuclear factor-kappa B (NF-κB) and Janus kinase/signal transducer and activator of transcription (JAK/STAT) play pivotal roles in IBD pathogenesis. By altering these pathways, pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β are suppressed, lowering inflammation and re-establishing immunological balance. Novel treatments for IBD have been developed using metal-based nanozymes that are designed to replicate natural enzymatic processes. These nanozymes, including iron-doped, zinc-doped, ceria-doped, transition metal-doped, and noble metal-doped variants, exhibit robust catalytic activities, such as superoxide dismutase (SOD)-like, catalase (CAT)-like, and peroxidase (POD)-like functions. By scavenging reactive oxygen species (ROS) and restoring redox balance, they mitigate oxidative stress, a key driver of IBD progression. These nanozymes interact with important signaling pathways linked to IBD in addition to their enzymatic roles. They inhibit NF-κB signaling, reducing the release of pro-inflammatory cytokines, and regulate the JAK/STAT pathway to balance immunological responses. Their therapeutic potential is increased by this dual action, which concurrently addresses immunological dysregulation and oxidative stress. Metal-doped nanozymes are a promising substitute for conventional anti-inflammatory and immunosuppressive therapies due to their precise, targeted action. The review article explores the latest developments in metal based nanozyme research, their catalytic characteristics, and how they affect IBD treatment, as well as potential future paths for the area.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102747"},"PeriodicalIF":13.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Administration route-commended concise organ-selective mRNA transfection (ACCOST) by cyclic disulfide-primed short polyethylenimine 给药途径推荐的简明器官选择性mRNA转染（ACCOST）由环二硫醚引发的短聚亚胺

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102741

Ruonan Ye , Qiongzhe Ren , Limin Chang , Siqi Zhang , Changchang Deng , Li Cao , Meng Shi , Bo Lou , Fenghua Meng , Shi Du , Keyun Ren , Xijun Piao , Congcong Xu , Zhiyuan Zhong

{"title":"Administration route-commended concise organ-selective mRNA transfection (ACCOST) by cyclic disulfide-primed short polyethylenimine","authors":"Ruonan Ye , Qiongzhe Ren , Limin Chang , Siqi Zhang , Changchang Deng , Li Cao , Meng Shi , Bo Lou , Fenghua Meng , Shi Du , Keyun Ren , Xijun Piao , Congcong Xu , Zhiyuan Zhong","doi":"10.1016/j.nantod.2025.102741","DOIUrl":"10.1016/j.nantod.2025.102741","url":null,"abstract":"<div><div>mRNA technology holds great promise for addressing a spectrum of diseases. Achieving widespread clinical utility of mRNA therapeutics requires effective transfection of mRNA to specific organs. Here we introduce a cyclic disulfide-primed short polyethyleneimine (CD-PEI) polymer that demonstrates administration route-commended concise organ-selective mRNA transfection (ACCOST) <em>in vivo</em>. The cyclic disulfide groups on the PEI polymer facilitate thiol-mediated cytosolic mRNA delivery and high transfection of different types of cells including hard-to-transfect immune cells. Remarkably, CD-PEI-mRNA complex achieves nearly 100 % organ-specific transfection in pancreas, lymph nodes, brain/spinal cord, and spleen <em>via</em> intraperitoneal, subcutaneous, intrathecal injection, and intravenous injections, respectively, with negligible accumulation in non-target organs. The intravenous injection to pregnant mice results in selective mRNA expression in the placenta instead. The spleen targeting occurs likely <em>via</em> erythrocyte-hijacking mechanism and systemically administered mRNA vaccines elicit robust antigen-specific anti-tumor immunity in murine B16-OVA model. Therefore, our ACCOST technology presents a novel strategy for organ-specific mRNA transfection.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102741"},"PeriodicalIF":13.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visualizing the substrate-dependent structural evolution of Na2WO4 via in-situ transmission electron microscopy 通过原位透射电镜观察Na2WO4的结构演变

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102751

Kunkun Wei , Yutao Ren , Yilin Zhao , Fangwei Liu , Xutao Chen , Yue Wang , Shihui Zou , Chengyuan Liu , Yang Pan , Jianguo Huang , Wentao Yuan , Zhongkang Han , Yong Wang , Jie Fan

{"title":"Visualizing the substrate-dependent structural evolution of Na2WO4 via in-situ transmission electron microscopy","authors":"Kunkun Wei , Yutao Ren , Yilin Zhao , Fangwei Liu , Xutao Chen , Yue Wang , Shihui Zou , Chengyuan Liu , Yang Pan , Jianguo Huang , Wentao Yuan , Zhongkang Han , Yong Wang , Jie Fan","doi":"10.1016/j.nantod.2025.102751","DOIUrl":"10.1016/j.nantod.2025.102751","url":null,"abstract":"<div><div>Supported nanocatalysts often undergo sintering at elevated temperatures, whereas the dispersion of large particles into small particles is uncommon. Here, we discover that Na<sub>2</sub>WO<sub>4</sub> evolves from large bulk particles to evenly distributed high-concentration nanoclusters on the ZrO<sub>2</sub> surface but remains as large particles on the TiO<sub>2</sub> surface at high temperatures. This substrate-dependent structural evolution is visualized by in-situ transmission electron microscopy and rationalized by the differing interactions between Na<sub>2</sub>WO<sub>4</sub> and the substrates. The great potential of this substrate-dependent structural evolution in developing advanced Na<sub>2</sub>WO<sub>4</sub> cluster catalysts is demonstrated using methyl chloride-to-vinyl chloride as a probe reaction. Benefiting from the presence of high-concentration Na<sub>2</sub>WO<sub>4</sub> nanoclusters that effectively couple ·CH<sub>2</sub>Cl radicals, Na<sub>2</sub>WO<sub>4</sub>/ZrO<sub>2</sub> exhibits a C<sub>2</sub>H<sub>3</sub>Cl selectivity of 31.9 % and a yield of 20.0 % at 700 °C, which is much higher than those of Na<sub>2</sub>WO<sub>4</sub>/TiO<sub>2</sub>.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102751"},"PeriodicalIF":13.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nuclei bombing nano-system improves STING-activated cancer immunotherapy 核轰炸纳米系统改善了针刺激活的癌症免疫治疗

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102749

Shuai Guo , Tianwang Guan , Rundong Tai , Long Ma , Yushen Ke , Jujian Ye , Huiwan Chen , Yuxuan Pan , Xiaodong Ning , Xueqin Shi , Zhilin Deng , Yafang Xiao , Shaohui Deng , Peier Chen , Zhenhua Li , Xiaozhong Qiu , Kelong Fan , Zheyu Shen , Caiwen Ou

{"title":"A nuclei bombing nano-system improves STING-activated cancer immunotherapy","authors":"Shuai Guo , Tianwang Guan , Rundong Tai , Long Ma , Yushen Ke , Jujian Ye , Huiwan Chen , Yuxuan Pan , Xiaodong Ning , Xueqin Shi , Zhilin Deng , Yafang Xiao , Shaohui Deng , Peier Chen , Zhenhua Li , Xiaozhong Qiu , Kelong Fan , Zheyu Shen , Caiwen Ou","doi":"10.1016/j.nantod.2025.102749","DOIUrl":"10.1016/j.nantod.2025.102749","url":null,"abstract":"<div><div>The activation of the stimulator of interferon genes (STING) pathway presents a promising therapeutic strategy for pancreatic cancer by enhancing immune responses and reprogramming the immunosuppressive tumor microenvironment (TME). Ferroptosis, an iron-dependent form of cell death, can synergize with STING activation through reactive oxygen species (ROS)-induced DNA damage. However, its efficacy is hindered by poor vascularization, inefficient delivery of STING agonists, and tumor resistance mechanisms that suppress ROS levels. To overcome these limitations, we developed a \"nuclei bombing\" nano-system using extremely small cuprous oxide modified magneto-human heavy chain ferritin (ES-CO@M-HFn). This system targets pancreatic cancer cells overexpressing transferrin receptor 1 (TfR1) and releases Cu<sup>+</sup> and Fe<sup>3+</sup> ions in response to the acidic (pH 6.8) and glutathione (GSH)-rich TME. These ions form a Cu-Fe catalytic cycle under high H₂O₂ levels, continuously generating Fe<sup>2+</sup>, Cu<sup>+</sup>, and robust ROS, thereby inducing ferroptosis and cuproptosis. This creates a synergistic feedback loop that amplifies oxidative damage, leading to extensive DNA damage and tumor cell destruction—termed the \"nuclei bombing\" effect. The resulting DNA fragments activate the STING pathway, reprogramming the TME by maturing dendritic cells, repolarizing macrophages, and activating CD8<sup>+</sup> T cells. This comprehensive approach generates a potent immune response, significantly suppressing tumor growth and metastasis, and offers a transformative strategy for pancreatic cancer treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102749"},"PeriodicalIF":13.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The peptide-Au clusters inhibit EGFR exon 19 deletion mutant non-small cell lung cancer 肽- au簇抑制EGFR外显子19缺失突变体非小细胞肺癌

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102744

Wencong Zhao , Wendi Huo , Haoran Dang , Zhongying Du , Qing Yuan , Kai Cao , Xueyun Gao

{"title":"The peptide-Au clusters inhibit EGFR exon 19 deletion mutant non-small cell lung cancer","authors":"Wencong Zhao , Wendi Huo , Haoran Dang , Zhongying Du , Qing Yuan , Kai Cao , Xueyun Gao","doi":"10.1016/j.nantod.2025.102744","DOIUrl":"10.1016/j.nantod.2025.102744","url":null,"abstract":"<div><div>Epidermal growth factor receptor (EGFR) exon 19 deletions are a common mutation that can lead to non-small cell lung cancer (NSCLC). Here, we designed and synthesized Au clusters coated with EGFR-target peptides to treat EGFR exon 19 deletions mutated NSCLC. Two sequences of peptides (namely P1 and P2 peptide) were designed for synthesis two Au clusters (namely P1-Au and P2-Au), respectively. These two clusters specifically target the extracellular region of EGFR and enter cancer cells through endocytosis. ICP-MS measurements, enzyme activity experiments and cytotoxicity studies in H1650 cells (exon 19 deletions of EGFR) demonstrated that P1-Au clusters have stronger targeting ability towards EGFR, well inhibits EGFR phosphorylation and outcome a better anti-tumor effect than that of P2-Au clusters. Further experiments revealed that the P1-Au clusters enter H1650 cells through the clathrin-mediated endocytosis pathway, escape from lysosomes to the cytoplasm, and inhibit the phosphorylation of EGFR exon 19 deletions and its downstream protein to induce cancer cell apoptosis. P1-Au clusters significantly inhibited the tumor growth in an H1650 xenograft model via suppress EGFR exon 19 deletions mutant activation.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102744"},"PeriodicalIF":13.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing Zn-volatility for compositional tuning in PtZn nanoalloy catalysts 利用锌挥发性调整PtZn纳米合金催化剂的组成

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-04 DOI: 10.1016/j.nantod.2025.102746

Bingqing Yao , Chaokai Xu , Yaxin Tang , Yankun Du , Shengdong Tan , Sheng Dai , Guangfu Luo , Qian He

{"title":"Harnessing Zn-volatility for compositional tuning in PtZn nanoalloy catalysts","authors":"Bingqing Yao , Chaokai Xu , Yaxin Tang , Yankun Du , Shengdong Tan , Sheng Dai , Guangfu Luo , Qian He","doi":"10.1016/j.nantod.2025.102746","DOIUrl":"10.1016/j.nantod.2025.102746","url":null,"abstract":"<div><div>Bimetallic nanoalloys have gained extensive attention due to their tunable properties and wide range of catalytic applications. However, achieving good compositional control in nanoalloy catalysts remains a formidable challenge. In this work, we demonstrate that heat treatment can be used to tune the composition of Pt-Zn nanoalloy catalysts, leveraging the volatile nature of zinc to enhance their performance in propane dehydrogenation. Through identical location scanning transmission electron microscopy (IL-STEM) using an <em>in situ</em> gas cell, as well as other complementary techniques, we observed that the zinc content of the Pt-Zn nanoalloy particles can be tuned <em>via</em> heat treatment under hydrogen. The extent of change appeared to be influenced by experimental details such as the original composition of the particles, as well as heat treatment conditions such as temperature and flow rate. Our experimental results, supported by theoretical calculations, suggest that Zn volatilization can be controlled when the alloys reach certain compositions such as the intermetallic phase. This approach offers a new strategy for developing better Pt-Zn catalysts.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102746"},"PeriodicalIF":13.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Building high-contrast afterglow nanoprobe using semiconducting polymer nanoparticles and CuRu nanozyme for prolonged surgical navigation 利用半导体聚合物纳米颗粒和CuRu纳米酶构建高对比度余辉纳米探针，用于手术导航

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-04 DOI: 10.1016/j.nantod.2025.102750

Di Zhao , Aifang Zhou , Tengfei Zhang , Chen Han , Hong-Min Meng , Yuehe Lin , Zhaohui Li

{"title":"Building high-contrast afterglow nanoprobe using semiconducting polymer nanoparticles and CuRu nanozyme for prolonged surgical navigation","authors":"Di Zhao , Aifang Zhou , Tengfei Zhang , Chen Han , Hong-Min Meng , Yuehe Lin , Zhaohui Li","doi":"10.1016/j.nantod.2025.102750","DOIUrl":"10.1016/j.nantod.2025.102750","url":null,"abstract":"<div><div>Precise real-time imaging of tumor boundary is critical for effectively and thoroughly eliminating tumor residuals during surgery to prevent recurrence. Organic afterglow luminescent probes, well known for their high signal-to-background ratio (SBR), are particularly promising for imaging <em>in vivo</em>. However, current afterglow imaging systems still face limitations in surgical navigation: \"always-on\" probes offer poor contrast between the tumor area and surrounding normal tissues, and lack the enduring imaging capability needed for complete tumor excision. In this work, we developed a novel tumor microenvironment-activated afterglow nanoprobe, denoted as FMCR, by integrating the semiconducting polymer 2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene (MEHPPV) with CuRu nanozyme for enhanced intravital afterglow imaging. The CuRu nanozyme component of FMCR exhibits robust catalase-like activity, continuously catalyzing the conversion of overexpressed hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) present in the tumor microenvironment to oxygen (O<sub>2</sub>), which increased the aerobic afterglow signal distinctly. More importantly, this CuRu nanozyme could sustainably and stably produce O<sub>2</sub> by catalyzing endogenous H<sub>2</sub>O<sub>2</sub> over the long term, greatly prolonging the decay time of afterglow imaging. <em>In vivo</em> experiments revealed that FMCR facilitated the imaging of subcutaneously xenografted 4T1 tumors in living mice, with a remarkable SBR of 20.18. Furthermore, guided by afterglow imaging of FMCR, surgery was performed to effectively remove intraperitoneal tumor nodules, including those as smaller as 2–4.5 mm in diameter, which demonstrated the immense potential of FMCR for precise surgical navigation.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102750"},"PeriodicalIF":13.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corneal endothelial dysfunction treatments: Recent advances in non-invasive treatment strategies 角膜内皮功能障碍治疗：非侵入性治疗策略的最新进展

IF 13.2 1区材料科学

Nano Today Pub Date : 2025-04-02 DOI: 10.1016/j.nantod.2025.102740

Nataliia Gnyliukh , Rabah Boukherroub , Sabine Szunerits

引用次数: 0