Nano TodayPub Date : 2024-10-30DOI: 10.1016/j.nantod.2024.102532
Yuye Li , Jing Xia , Xuanze Li , Lifeng Tian , Peiyu Qiao , Jianyu Cao , Zhongshi Zhang , Qing Meng , Jiangtao Li , Chang Liu , Xiangmin Meng
{"title":"Atomic-scale imaging of structural evolution from anatase TiO2 to cubic TiO under electron beam irradiation","authors":"Yuye Li , Jing Xia , Xuanze Li , Lifeng Tian , Peiyu Qiao , Jianyu Cao , Zhongshi Zhang , Qing Meng , Jiangtao Li , Chang Liu , Xiangmin Meng","doi":"10.1016/j.nantod.2024.102532","DOIUrl":"10.1016/j.nantod.2024.102532","url":null,"abstract":"<div><div>The introduction of oxygen vacancies into transition metal oxides can change their phases and electronic structures, subsequently impacting the physical and chemical properties. However, comprehensively understanding the phase transition process at the atomic scale remains challenging. Here, we directly image the atomic structural evolution from anatase TiO<sub>2</sub> to cubic TiO under electron beam irradiation via in-situ scanning transmission electron microscope and electron energy loss spectroscopy, with a detailed analysis of the TiO/TiO<sub>2</sub> interfacial structure. During this process, electron beam irradiation induces the formation of oxygen vacancies on the TiO<sub>2</sub> surface, which drives the migration and rearrangement of Ti atoms. Theoretical and experimental methods are employed to provide insight into possible migration paths. Moreover, the formation of TiO is detected from other directions, but less distinct than that observed on the (010)<sub>TiO2</sub> facet. This demonstrates an interesting facet dependence attributed to variations in the formation energies of surface oxygen vacancies. In addition, subsequent irradiation on TiO does not induce new structural change, but only surface roughening. Our findings offer valuable atomic-scale insights to the complex structural evolution as well as a new method to precisely manipulate phases of the transition metal oxides.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102532"},"PeriodicalIF":13.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2024-10-30DOI: 10.1016/j.nantod.2024.102537
Shanshan Liang , Bing Wang , Wei Chen , Tingfeng Zhang , Hao Fang , Minglu Zhang , Si Xu , Zongyi Su , Lingna Zheng , Meng Wang , Xiao He , Weiyue Feng
{"title":"Tunable multi-responsive N-heterocyclic carbene-gold nanoenzyme for tumor-specific pyroptosis and immune activation in cancer therapy","authors":"Shanshan Liang , Bing Wang , Wei Chen , Tingfeng Zhang , Hao Fang , Minglu Zhang , Si Xu , Zongyi Su , Lingna Zheng , Meng Wang , Xiao He , Weiyue Feng","doi":"10.1016/j.nantod.2024.102537","DOIUrl":"10.1016/j.nantod.2024.102537","url":null,"abstract":"<div><div>Heterogeneity of the tumor microenvironment (TME) poses significant obstacles to effective tumor treatment. Pyroptosis-based immunogenic cell death (ICD) therapy is an ideal strategy to overcome TME heterogeneity and achieve a satisfactory antitumor effect. However, specific activation of pyroptosis in tumors while sparing normal tissue still remains a great challenge. Here, we have developed novel, biocompatible N-heterocyclic carbenes-gold nanoparticles (NHC@AuNPs) as TME-responsive nanoenzyme and potential pyroptosis inducers through an azide-alkyne cycloaddition “click” reaction and direct aurophilic interaction (Au<sup>I</sup>∙∙∙Au<sup>I</sup>). The NHC@AuNPs demonstrated tunable multi-responsive abilities within the TME, including superior peroxidase (POD) activity, GSH depletion through on-site cleavage Au-Au bond, inhibition of thioredoxin reductase and enhancement of ROS. This ROS buildup damages mitochondria, further enhancing H<sub>2</sub>O<sub>2</sub> release and amplifying the catalytic cycle of ROS production. NHC ligation also exhibited enhanced fusion of NPs with the lipid bilayer, promoting high intracellular uptake in cancer cells. <em>In vitro</em> and <em>in vivo</em> experiments demonstrated that NHC@AuNPs effectively trigger pyroptosis in tumor cells through the ROS-modulated NLRP3/caspase-1/GSDMD pathway and activate antitumor immunity, such as the increased infiltration of CD4<sup>+</sup> and CD8<sup>+</sup> T cells, as well as the significant release of proinflammatory cytokines. These findings provide valuable insights for designing pyroptosis-inducer in cancer therapies.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102537"},"PeriodicalIF":13.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2024-10-30DOI: 10.1016/j.nantod.2024.102540
Yatong Zhu , Wen Ai , Mao Ye , Chen Li , Mingrui Zhou , Fuqiang Chu , Guocai Dong , Yilong Zhou , Xiaohui Hu , Tao Xu , Litao Sun
{"title":"Deriving 2D in-plane heterostructures in TMDC nanosheets via electron beam irradiation","authors":"Yatong Zhu , Wen Ai , Mao Ye , Chen Li , Mingrui Zhou , Fuqiang Chu , Guocai Dong , Yilong Zhou , Xiaohui Hu , Tao Xu , Litao Sun","doi":"10.1016/j.nantod.2024.102540","DOIUrl":"10.1016/j.nantod.2024.102540","url":null,"abstract":"<div><div>2D in-plane heterostructures can enhance the electronic performance of hybrid systems, allowing for a variety of electronic device applications. However, precisely achieving uniform in-plane heterostructures with seamless interfaces at the same atomic planes remains a challenge. In this work, 2D in-plane heterostructures were successfully fabricated through electron beam irradiation-induced phase transformation in transition metal dichalcogenides (TMDCs). The transformed phases were seamlessly connected to the pristine TMDCs, forming ultraclean and atomically sharp interfaces of heterostructures. The phases were stable and determined to be novel tetragonal-like atomic structures by experimental and theoretical analyses. <em>In situ</em> transmission electron microscopy revealed that the phase transition involved atomic loss, lattice contraction, and then significant structural reconstruction in the pristine TMDCs. These results demonstrate that electron irradiation can efficiently achieve precise manufacturing of 2D in-plane heterostructures, offering new opportunities for the development of high-quality 2D in-plane heterostructures and novel 2D devices with high performance.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102540"},"PeriodicalIF":13.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2024-10-29DOI: 10.1016/j.nantod.2024.102535
Yongjuan Li , Xinyan Li , Mengzhe Zhang , Xiao Weng , Jinmeng Yi , Yongjian Cao , Ningjing Lei , Zhihai Qin , Xiaoyuan Chen , Weijing Yang
{"title":"Spatiotemporal orchestration of a ferroptosis-immunotherapy “cycle” via a sequential drug delivery system for antitumor immunity","authors":"Yongjuan Li , Xinyan Li , Mengzhe Zhang , Xiao Weng , Jinmeng Yi , Yongjian Cao , Ningjing Lei , Zhihai Qin , Xiaoyuan Chen , Weijing Yang","doi":"10.1016/j.nantod.2024.102535","DOIUrl":"10.1016/j.nantod.2024.102535","url":null,"abstract":"<div><div>Interferon-gamma (IFN-γ) and iron can induce ferroptosis; however, distinct target sites restrict their synergistic therapeutic efficacy in simple combination therapy. Herein, two nanoplatforms are constructed with the same polymeric skeleton but different payloads to separately target antigen-presenting cells (APCs) and tumor cells for amplified ferroptosis in immunotherapy. Negatively charged 2′,3′-cyclic GMP-AMP is electronically loaded in pH-responsive nanoparticles (PNPs@cGAMP), which activates the stimulator of interferon gene (STING) pathway in APCs, accompanied by an immune response activation cascade with IFN-γ secretion for tumor ferroptosis. Gossypol is conjugated to the polymer chain by forming a pH-sensitive Schiff base that further coordinates with ferric iron (Fe<sup>3+</sup>) to self-assemble into another size-switchable nanoprodrug (PGNPs@Fe). In the acidic tumor microenvironment, PGNPs@Fe shrinks into Gos@Fe for deeper tumor penetration, which disassembles into Fe<sup>3+</sup> and gossypol for lipid peroxide generation, resulting in ferroptosis and immunogenic cell death. Compared to multiple administrations of a single nanoformulation, this ferroptosis-immunotherapy \"cycle\" exhibits notably improved antitumor activity in subcutaneous xenograft and distal metastatic B16F10 tumor models. The mouse survival rate is significantly prolonged after combination with immune checkpoint blockade. This design emphasizes the spatiotemporal orchestration of payloads and provides novel perspectives on intelligent nanotherapeutics combinations for future clinical applications.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102535"},"PeriodicalIF":13.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2024-10-28DOI: 10.1016/j.nantod.2024.102534
Tien Dat Ngo , Je-Jun Lee , Hyung-Seok Bae , Tuyen Huynh , Kwangro Lee , Myeongjin Lee , Yasir Hassan , Ji-In Park , Hee-Suk Chung , Jin-Hong Park , Won Jong Yoo , Min Sup Choi
{"title":"Opposite synaptic plasticity in oxidation-layer-controlled 2D materials-based memristors for mimicking heterosynaptic plasticity","authors":"Tien Dat Ngo , Je-Jun Lee , Hyung-Seok Bae , Tuyen Huynh , Kwangro Lee , Myeongjin Lee , Yasir Hassan , Ji-In Park , Hee-Suk Chung , Jin-Hong Park , Won Jong Yoo , Min Sup Choi","doi":"10.1016/j.nantod.2024.102534","DOIUrl":"10.1016/j.nantod.2024.102534","url":null,"abstract":"<div><div>Memristors with nonstoichiometric tungsten oxide (WO<sub>x</sub>) as an active layer, derived from the oxidation of atomically thin two-dimensional tungsten diselenide (WSe<sub>2</sub>), enable the creation of the monolithic layered structure of WO<sub>x</sub>/WSe<sub>2</sub>. These devices are promising candidates for emulating various biological synaptic functions in the human brain. In this study, we fabricate monolithic few-layer WO<sub>x</sub>/WSe<sub>2</sub> memristors with precisely controlled WO<sub>x</sub> thickness by UV-ozone treatment from 1 L to 9 L, depending on chuck temperature. The postsynaptic responses of the topmost single-layer (1 L) oxidized WSe<sub>2</sub> and fully (9 L) oxidized WSe<sub>2</sub> memristors exhibit sharply contrasting behaviors, which can be applied to mimic the heterosynaptic plasticity in the CA1 region of the hippocampus. Beyond the significance of emulating the biological synaptic characteristics, we explore the feasibility of using each oxidation-layer-controlled memristor as a hardware accelerator. Their performances are assessed through application in a CIFAR-10 pattern recognition task using a convolutional neural network. Pattern recognition rates of 84 % and 71 % are obtained for the 1 L and 9 L WO<sub>x</sub>-based devices, respectively. We also examine the applicability of a synaptic cell composed of devices with oppositely switched characteristics. Consequently, the synaptic weight—defined as the difference in conductance between two synaptic devices—can be either increased (potentiated) or decreased (depressed) by simultaneously updating both devices with the same voltage signal. This weight update concept achieves a moderate recognition rate of 85.94 % when using an MNIST pattern-based recognition task, simplifying the complex weight-adjustment process.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102534"},"PeriodicalIF":13.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2024-10-28DOI: 10.1016/j.nantod.2024.102538
Yuan Yu , Menggang Li , Miao Sun , Zhaolin Yang , Yifan Liu , Senwei Hu , Jiazuo Zhou , Yudong Li , Haiyue Yang , Chengyu Wang
{"title":"Bone-inspired MXene nano aerogels toward self-electricity generation and capacitive energy storage","authors":"Yuan Yu , Menggang Li , Miao Sun , Zhaolin Yang , Yifan Liu , Senwei Hu , Jiazuo Zhou , Yudong Li , Haiyue Yang , Chengyu Wang","doi":"10.1016/j.nantod.2024.102538","DOIUrl":"10.1016/j.nantod.2024.102538","url":null,"abstract":"<div><div>The exceptional potential of MXene aerogels for practical applications is impeded by the energy-intensive processing and insufficient mechanical stability. Inspired by natural bones, herein, we report the MXene@regenerated nanocellulose aerogel (MRCA) with strong mechanical performance <em>via</em> dual aerogel fabrication to achieve high-performance energy generation and storage. The MRCA achieves a gravimetric capacitance of 1271.16 F g<sup>−1</sup> at 2 mA cm<sup>−2</sup>, and the energy density of the eco-friendly symmetrical MRCA-based solid-state supercapacitor reaches 0.11 mWh cm<sup>−2</sup>, positioning it as a top contender among most state-of-the-art MXene-based electrodes. Additionally, the MRCA exhibits a robust specific tensile strength of 68.35 MPa cm<sup>3</sup> g<sup>−1</sup>, resembling bone-like resilience. Therefore, MRCA can swiftly generate an open-circuit voltage of 181.24 V. The instant high voltage of MRCA transforms into diverse signals, driving MRCA-SC to release energy for electric devices in practical scenarios, paving the way for future sustainable power systems.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102538"},"PeriodicalIF":13.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2024-10-28DOI: 10.1016/j.nantod.2024.102531
Yang Chen , Jia Huang , Hanchen Zhang , Fuzhen Hu , Zheng Cao , Zhiying Yang , Haiqin Song , Rong Liu
{"title":"Targeting ferroptosis with polymerized platinum (IV) prodrugs nanoparticles with everolimus for enhancing therapeutic efficacy on cholangiocarcinoma","authors":"Yang Chen , Jia Huang , Hanchen Zhang , Fuzhen Hu , Zheng Cao , Zhiying Yang , Haiqin Song , Rong Liu","doi":"10.1016/j.nantod.2024.102531","DOIUrl":"10.1016/j.nantod.2024.102531","url":null,"abstract":"<div><div>Strategies to induce ferroptosis in tumor cells have been widely adopted for the treatment of cancer. Traditional single-target ferroptosis inducers, however, have shown limited efficacy. Tumor cells often counteract these drugs through mechanisms by high levels of glutathione (GSH) detoxification of lipid peroxidases. To address these challenges, we have developed a GSH-responsive amphiphilic polymer with polymerized platinum(IV) prodrugs (Poly-CisPt (IV)), capable of encapsulating everolimus (a mTORC1 inhibitor) into nanoparticles (NP@Ev). This strategy facilitates the concurrent depletion of GSH and the release of cisplatin and everolimus. On the one hand, the released cisplatin simultaneously induces cell apoptosis and impairs the GPX4 enzyme. On the other hand, everolimus disrupts the mTOR signaling pathway, inhibiting tumor cell proliferation and inducing the production of reactive oxygen species (ROS) and lipid peroxides, which leads to mitochondrial dysfunction and ferroptosis. Our study indicated that NP@Ev effectively induced ferroptosis and significantly inhibited the progression of human cholangiocarcinoma in murine models, with limited toxicity. These findings underscore the potential of NP@Ev as a promising avenue for the clinical multimodal treatment of cholangiocarcinoma.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102531"},"PeriodicalIF":13.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2024-10-28DOI: 10.1016/j.nantod.2024.102530
Zhanhao Zhou , Hongbing Lan , Hongyuan Tan , Yi Wang , Wei Chen , Samira Batur , Chuansheng Fu , Li Kong , Conglian Yang , Boning Niu , Yuanyuan Guo , Zhiping Zhang , Kai Huang
{"title":"ROS-responsive biomimetic nanovesicles to plaque microenvironment in targeted therapy of atherosclerosis","authors":"Zhanhao Zhou , Hongbing Lan , Hongyuan Tan , Yi Wang , Wei Chen , Samira Batur , Chuansheng Fu , Li Kong , Conglian Yang , Boning Niu , Yuanyuan Guo , Zhiping Zhang , Kai Huang","doi":"10.1016/j.nantod.2024.102530","DOIUrl":"10.1016/j.nantod.2024.102530","url":null,"abstract":"<div><div>Atherosclerosis, characterized by the accumulation of inflammatory cells at localised inflammatory sites with a high concentration of reactive oxygen species (ROS), is a leading cause of cardiovascular morbidity and mortality worldwide. There is a paucity of studies that effectively coordinate the targeting of inflammatory microenvironment and the controlled release of biomimetic carriers. Here, in view of the oxidative stress and inflammatory characteristics observed in the plaque microenvironment of atherosclerosis lesions, we propose an anti-inflammatory M2 macrophage membrane-derived nanovesicles co-fused with lipids containing ROS-sensitive thioketal (TK) linker and loaded with rapamycin (Rapa) to form a biomimetic hybrid system (Rapa@TLNVs). Benefiting from the inflammatory tendency of vesicles and ROS response of TK, Rapa@TLNVs can be delivered to plaque lesions and responsively release Rapa to synergistically help suppressing inflammation. Additionally, Rapa@TLNVs can reduce foam cells formation and the proliferation of macrophages. Following the administration of Rapa@TLNVs to ApoE<sup>−/−</sup> mice, a series of effects have been observed, including reductions in the inflammatory response, lipid deposition and increased plaque stability. Consequently, this work exploits the characteristics of the atherosclerosis plaque microenvironment to provide a promising strategy for combating atherosclerosis. This may further enrich the application experience of biomimetic hybrid nanovesicle platforms in atherosclerosis therapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102530"},"PeriodicalIF":13.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Virus-mimicking nanodrug active crossing of the blood-brain barrier via transcytosis against central nervous system leukemia","authors":"Xue Dong , Wei Wu , Cheng-Ling Zhang , Rui-Hao Huang , Qin Wen , Xi Zhang","doi":"10.1016/j.nantod.2024.102536","DOIUrl":"10.1016/j.nantod.2024.102536","url":null,"abstract":"<div><div>The poor central nervous system leukemia (CNSL) clinical efficacy of conventional doses of chemotherapy is mainly attributed to the limited permeability of chemotherapy agents caused by the blood-brain barrier (BBB). Effectively enhancing the accumulation of drugs across the BBB in the central nervous system is one of the key challenges in improving patient compliance and clinical efficacy of CNSL. Here, we find that the VP1 protein, the functional module of the John Cunningham (JC) virus, can safely penetrate the BBB through a sialic acid receptor-mediated transcytosis mechanism. Based on this, we develop a JC virus-mimicking nanodrug delivery platform based on VP1 protein-conjugated self-assembled nanoparticles (MFHV), which can active target and cross the BBB <em>via</em> a receptor-mediated transcytosis for safe and effective low-dose chemotherapy against CNSL after systemic administration. The results demonstrate that such a platform can penetrate the BBB through the dual mechanism of clathrin-mediated endocytosis and micropinocytosis pathway. When further synergistic with ferroptosis and histamine metabolism, the long-term survivors of low-dose MTX are significantly enhanced by 83.3 % and 56.7 % in two CNSL mice models. Collectively, this study takes a new perspective on natural living materials and molecule targeting of the BBB to present a promising strategy for low-dose chemotherapy against CNSL with safety and efficacy, which might provide a clinically translatable option for the prevention and treatment of CNSL.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102536"},"PeriodicalIF":13.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TodayPub Date : 2024-10-24DOI: 10.1016/j.nantod.2024.102528
Yifan Yin , Zifan Pei , Chengyu Hu , Yixuan Sun , Qinyuan Jia , Hongfei Yao , Yuheng Zhu , Zonghao Duan , Feng Yu , Dejun Liu , Yongwei Sun , Nan Jiang , Fei Gong , Nailin Yang , Liang Cheng , Wei Liu
{"title":"A potent nano-strategy for dual energy deprivation to inhibit pancreatic cancer progression","authors":"Yifan Yin , Zifan Pei , Chengyu Hu , Yixuan Sun , Qinyuan Jia , Hongfei Yao , Yuheng Zhu , Zonghao Duan , Feng Yu , Dejun Liu , Yongwei Sun , Nan Jiang , Fei Gong , Nailin Yang , Liang Cheng , Wei Liu","doi":"10.1016/j.nantod.2024.102528","DOIUrl":"10.1016/j.nantod.2024.102528","url":null,"abstract":"<div><div>Pancreatic cancer is a highly malignant tumor that poses significant threats to public health, and glycolysis plays a crucial role in its energy metabolism. Here, glycolysis was confirmed to be directly associated with poor prognosis through the use of clinical samples from 130 patients with pancreatic ductal adenocarcinoma (PDAC), and the effectiveness of zinc ions (Zn<sup>2+</sup>) in inhibiting glycolysis-related genes was further validated. Therefore, polyvinyl pyrrolidone (PVP)-modified zinc sulfide nanomedicines (ZnS-PVP) were developed for dual energy suppression by targeting glycolysis and mitochondrial respiration in pancreatic cancer. On the one hand, the released Zn<sup>2+</sup> efficiently inhibited glycolysis in pancreatic cancer cells through the PI3K-Akt-mTOR-HIF-1α signaling axis. On the other hand, acid-responsive release of hydrogen sulfide (H<sub>2</sub>S) gas damaged mitochondria and further reduced energy compensation by inhibiting oxidative phosphorylation. This two-pronged energy deprivation nano-strategy effectively eliminated pancreatic cancer cells and was proven to overcome chemotherapeutic resistance. Moreover, ZnS-PVP administration combined with immune checkpoint blockade (ICB) therapy significantly suppressed tumor progression in mouse orthotopic pancreatic tumor models, as also demonstrated in a pancreatic cancer patient-derived xenograft (PDX) model. Our work highlights the positive role of bioactive metal ions in targeting tumor energy metabolism and the great potential of nano-strategy for energy deprivation in the treatment of pancreatic cancer.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"59 ","pages":"Article 102528"},"PeriodicalIF":13.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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