Nano Today最新文献_第4页

Nanomedicine as core enablers: Mechanisms of mitophagy and theranostic strategies in ischemia-reperfusion injury 纳米医学作为核心推手：缺血再灌注损伤的线粒体自噬机制和治疗策略

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-04-01 Epub Date: 2026-02-13 DOI: 10.1016/j.nantod.2026.103005

Siyu Zhou , Xiaowen Wang , Jiangling Zhu , Jingcun Zheng , Xinran Song , Bingcang Huang , Yu Chen

{"title":"Nanomedicine as core enablers: Mechanisms of mitophagy and theranostic strategies in ischemia-reperfusion injury","authors":"Siyu Zhou , Xiaowen Wang , Jiangling Zhu , Jingcun Zheng , Xinran Song , Bingcang Huang , Yu Chen","doi":"10.1016/j.nantod.2026.103005","DOIUrl":"10.1016/j.nantod.2026.103005","url":null,"abstract":"<div><div>Ischemia-reperfusion (I/R) injury poses a significant clinical challenge in cardiovascular medicine, cerebrovascular disorders, and organ transplantation. Central to its pathology are mitochondrial dysfunction and aberrant mitophagy. Evidence indicates that moderate activation of mitophagy facilitates the clearance of damaged mitochondria and attenuates oxidative stress, thereby conferring neuroprotection and ameliorating injury in organs such as the brain. However, excessive or insufficient mitophagy activation, as well as autophagy dysregulation, may result in secondary injury, rendering precise mitophagy control a pivotal goal in current research. The advent of nanomedicine has provided new strategies by designing intelligent nanoplatforms that exploit the I/R microenvironment to trigger targeted drug release, achieve mitochondrial delivery, and regulate autophagy activity. In addition, mitophagy probes have enabled real-time monitoring, allowing accurate determination of the optimal timing and dosage for mitophagy intervention. This review systematically outlines the pathological mechanisms through which mitophagy contributes to I/R injury, surveys recent advances in mitophagy research across multiple organ systems, and highlights innovative nanomedicine-based strategies for therapeutic intervention. Looking forward, we emphasize the need to achieve spatiotemporally precise modulation of mitophagy, develop targeted therapeutics, and implement integrated nanotheranostic systems. These efforts are critical to advancing individualized and precision medicine approaches for I/R injury.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"68 ","pages":"Article 103005"},"PeriodicalIF":10.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle-enabled enhancement of plant photosynthesis: Mechanisms and applications 纳米粒子增强植物光合作用：机制和应用

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-04-01 Epub Date: 2026-02-12 DOI: 10.1016/j.nantod.2026.103003

Thi Linh Chi Tran , Lingxue Kong , Wenrong Yang , David Cahill

{"title":"Nanoparticle-enabled enhancement of plant photosynthesis: Mechanisms and applications","authors":"Thi Linh Chi Tran , Lingxue Kong , Wenrong Yang , David Cahill","doi":"10.1016/j.nantod.2026.103003","DOIUrl":"10.1016/j.nantod.2026.103003","url":null,"abstract":"<div><div>Enhancing photosynthesis, a fundamental process to convert light energy into chemical energy, is a frontier approach to increasing crop productivity. In recent years, nanoparticles (NPs) have emerged as promising tools to modulate photosynthetic performance, yet the mechanistic pathways connecting NP-plant interactions to photosynthetic responses remain unclear. Here, we provide an integrated synthesis of recent research on the impacts of NPs on photosynthesis from subcellular to whole plant level, an across-scale perspective that has been less systematically addressed in prior reviews. The effects of most investigated non-organic NP classes, including carbon-based such as carbon dots and carbon nanotubes and metal-based NPs such as SiO<sub>2</sub>, MoO<sub>3</sub>, ZnO, and Ag NPs are examined. Across both crop species such as lettuce and rice and model plants such as Arabidopsis and tobacco, we compare reported optimal concentrations (typically 10–100 mg/L) and emphasize the importance of appropriate controls, including untreated plants, bulk-material and ionic counterparts. Notably, this review delves into how NPs can enhance photosynthesis through both direct and indirect mechanism. It involves deeper consideration of how NPs influence light harvesting and photoconversion, excitation-energy regulation, electron transport, and thereby downstream impacts on CO<sub>2</sub> assimilation and the Calvin-Benson-Bassham (CBB) cycle. Common methods used to evaluate photosynthetic performance following NP treatments, as well as the relationship between NP uptake and their effects on photosynthesis, were also critically assessed. Overall, this review highlights how NP application and the rational design of targeted NP-based systems could improve photosynthesis and, in turn, enhance crop productivity and resilience under a changing climate.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"68 ","pages":"Article 103003"},"PeriodicalIF":10.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering hybrid nanodevices composed of DNA tetrahedrons and upconversion nanoparticles for spatiotemporally controlled imaging of multiple RNAs 由DNA四面体和上转换纳米颗粒组成的工程混合纳米器件，用于多rna的时空控制成像

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-04-01 Epub Date: 2026-02-04 DOI: 10.1016/j.nantod.2026.102999

Limin Yang , Qian Gao , Xiangyu Meng , Ting Hou , Panpan Gai , Juewen Liu , Feng Li

{"title":"Engineering hybrid nanodevices composed of DNA tetrahedrons and upconversion nanoparticles for spatiotemporally controlled imaging of multiple RNAs","authors":"Limin Yang , Qian Gao , Xiangyu Meng , Ting Hou , Panpan Gai , Juewen Liu , Feng Li","doi":"10.1016/j.nantod.2026.102999","DOIUrl":"10.1016/j.nantod.2026.102999","url":null,"abstract":"<div><div>Despite progress in reconfiguring DNA nanostructures for bioimaging, spatiotemporally controlled amplified RNA imaging remains challenging. In this work, we present a NIR light-activated, DNA-based hybrid nanodevice for spatiotemporally amplified imaging of multiple RNA species. This hybrid platform is constructed through engineering of photoactivatable catalytic hairpin assembly functional units integrated to a DNA tetrahedron, and further combination with upconversion nanoparticles that can convert NIR to UV light. The resulting nanosystem enables multiple RNAs imaging with improved detection sensitivity and biostability, and high spatiotemporal precision upon NIR light control. We further demonstrate the utility of this nanodevice for monitoring the fluctuation in microRNA-221 (miR-221) and PTEN mRNA levels induced by therapeutics, thereby providing insights into the abnormal activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. This advancement offers a promising strategy for controllable regulation of DNA nanodevices for diverse biomedical applications.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"68 ","pages":"Article 102999"},"PeriodicalIF":10.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LED light inhibits malignant tumors via high-density nanolocalized photothermal effects on cell membranes LED光通过对细胞膜的高密度纳米定位光热效应抑制恶性肿瘤

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-04-01 Epub Date: 2026-02-06 DOI: 10.1016/j.nantod.2026.103000

Yujie Qi , Hailang Dai , Yi Lai , Haojian Qiu , Yilin Huang , Ru Dan , Nan Zhang , You Wang , Xianfeng Chen

{"title":"LED light inhibits malignant tumors via high-density nanolocalized photothermal effects on cell membranes","authors":"Yujie Qi , Hailang Dai , Yi Lai , Haojian Qiu , Yilin Huang , Ru Dan , Nan Zhang , You Wang , Xianfeng Chen","doi":"10.1016/j.nantod.2026.103000","DOIUrl":"10.1016/j.nantod.2026.103000","url":null,"abstract":"<div><div>In traditional photothermal therapy (PTT), the collateral damage to surrounding normal tissues caused by strong laser radiation, and the cellular anti-apoptosis and cytoprotection mechanisms of cancer cells in mild hyperthermia PTT, severely limit the therapeutic efficacy of tumor treatment. Here, we present a targeted folic acid-modified Au-Ag nanoparticle-nanowire construct (FA-Au-Ag NPs-NW) that specifically targets and binds to the folate receptor-overexpressing membranes of cancer cells. This construct enables efficient high-density nanoscale photothermal conversion under mild conventional LED irradiation, a property derived from the enhanced local surface plasmon resonance (LSPR) effect of the bimetallic Au-Ag heterostructure. Both in vitro and in vivo studies demonstrate that the construct avoids collateral damage to normal tissues, effectively inhibits the cellular anti-apoptotic and cytoprotective pathways, and induces tumor cell apoptosis through light-matter interactions, without the need for therapeutic drugs. This work offers a promising strategy for tumor treatment and broadens the application of LED-induced mild-temperature PTT for disease management.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"68 ","pages":"Article 103000"},"PeriodicalIF":10.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inspired by ion-specific effects: Repurposing metformin to tackle protein crystallopathy 受到离子特异性效应的启发：重新利用二甲双胍来解决蛋白质晶体病变

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-04-01 Epub Date: 2026-02-27 DOI: 10.1016/j.nantod.2026.103017

Wenbo Zhang , Shuyuan Li , Yang Wang , Xin Wang , Shanshan Mo , Longxin Xu , Zhongyi Jian , Shuli Liu , Zhenlin Liu , Yanlian Yang , Chen Wang , Yuxing Yao , Xiaoping Bao , Lanlan Yu , Xiaoguang Wang , Chenxuan Wang

{"title":"Inspired by ion-specific effects: Repurposing metformin to tackle protein crystallopathy","authors":"Wenbo Zhang , Shuyuan Li , Yang Wang , Xin Wang , Shanshan Mo , Longxin Xu , Zhongyi Jian , Shuli Liu , Zhenlin Liu , Yanlian Yang , Chen Wang , Yuxing Yao , Xiaoping Bao , Lanlan Yu , Xiaoguang Wang , Chenxuan Wang","doi":"10.1016/j.nantod.2026.103017","DOIUrl":"10.1016/j.nantod.2026.103017","url":null,"abstract":"<div><div>The spontaneous crystallization of galectin-10 (gal-10) <em>in vivo</em> is closely associated with the pathological mechanisms of certain intractable diseases, including eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP), for which targeted therapies are currently lacking. Gal-10 crystals have been identified as a promising target for clinical intervention against these diseases. However, the development of small-molecule drugs that target gal-10 crystallization has remained elusive. In this study, we discover an FDA-approved drug, metformin, which effectively induces the dissociation of gal-10 crystals <em>in vitro</em> by exploiting ion-specific effects that modulate the stability of protein crystals. We assess the therapeutic efficacy of metformin through both intratracheal and oral administration in a mouse model with gal-10 crystal-induced lung inflammation. Our results, including proinflammatory cytokine release and pathology tests, highlight the potency of metformin in ameliorating the symptoms of gal-10 crystallopathy <em>in vivo</em>. This work demonstrates a drug repurposing strategy that can guide the discovery of lead compounds for the treatment of protein crystallopathies.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"68 ","pages":"Article 103017"},"PeriodicalIF":10.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NIR-II-responsive violet phosphorus nanoplatform converts intratumoral bacteria into immunoadjuvants for enhanced photothermal immunotherapy nir - ii反应性紫磷纳米平台将肿瘤内细菌转化为增强光热免疫治疗的免疫佐剂

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1016/j.nantod.2026.103012

Xinyi Wang , Wen Li , Yiqiu Fu , Juntao Xie , Liu Yu , Rourou Miao , Jiahui Cao , Ting Chen , Xin Zhang , Yihai Chen , Zhuo Mao , Hanjie Zhang , Shouping Xu , Dunwan Zhu , Lin Mei , Meitong Ou

{"title":"NIR-II-responsive violet phosphorus nanoplatform converts intratumoral bacteria into immunoadjuvants for enhanced photothermal immunotherapy","authors":"Xinyi Wang , Wen Li , Yiqiu Fu , Juntao Xie , Liu Yu , Rourou Miao , Jiahui Cao , Ting Chen , Xin Zhang , Yihai Chen , Zhuo Mao , Hanjie Zhang , Shouping Xu , Dunwan Zhu , Lin Mei , Meitong Ou","doi":"10.1016/j.nantod.2026.103012","DOIUrl":"10.1016/j.nantod.2026.103012","url":null,"abstract":"<div><div>Intratumoral pathogenic bacteria influence tumor progression and affect responses to therapy, however, conventional antibacterial strategies face challenges including antibiotic resistance and nonspecific microbial disruption. Here, we report a NIR-II-responsive nanoplatform (VP-R@PEG-FA) that integrates violet phosphorus nanosheets (VPNSs) with the Toll-like receptor 7 (TLR7) agonist imiquimod (R837) and folate targeting for synergistic photothermal immunotherapy. Under 1064 nm laser irradiation, VP-R@PEG-FA generates localized hyperthermia that simultaneously eradicates tumor cells and intratumoral bacteria. This dual ablation strategy not only eliminates intratumoral pathogenic bacteria but also ingeniously converts them into in situ immunoadjuvants, as bacterial debris releases pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharides (LPS) which acts as an endogenous TLR4 agonist. The combination of bacterially derived TLR4 ligands and nanoparticle-delivered TLR7 agonist R837 induces potent combined immune activation, driving robust maturation of dendritic cells (DCs) and increasing CD8⁺ T cell infiltration. In 4T1 Triple-negative Breast Cancer (TNBC) models, this approach demonstrates significant primary tumor suppression and, notably, elicits abscopal effects in bilateral tumor models, indicating the enhanced systemic antitumor immunity. This work presents a “waste-to-wealth” strategy that repurposes intratumoral bacteria from immunosuppressive agents into immunostimulants, offering a promising strategy for advancing cancer immunotherapy through rational manipulation of the tumor microenvironment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"68 ","pages":"Article 103012"},"PeriodicalIF":10.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetics control of bilayer WSe2 growth for high-performance transistors by precursor modulation 基于前驱体调制的高性能晶体管双层WSe2生长动力学控制

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-04-01 Epub Date: 2026-02-04 DOI: 10.1016/j.nantod.2026.102998

Xiaojia Yin , Hui Wang , Biyuan Zheng , Penghui Guo , Yulong Yuan , Yihan Liao , Haitao Zhang , Jieyuan Liang , Haokai Zhou , Ke Luo , Yifan Zheng , Yu Zhou , Qitao Wu , Li Xiang , Anlian Pan

{"title":"Kinetics control of bilayer WSe2 growth for high-performance transistors by precursor modulation","authors":"Xiaojia Yin , Hui Wang , Biyuan Zheng , Penghui Guo , Yulong Yuan , Yihan Liao , Haitao Zhang , Jieyuan Liang , Haokai Zhou , Ke Luo , Yifan Zheng , Yu Zhou , Qitao Wu , Li Xiang , Anlian Pan","doi":"10.1016/j.nantod.2026.102998","DOIUrl":"10.1016/j.nantod.2026.102998","url":null,"abstract":"<div><div>The development of high-performance p-type two-dimensional (2D) semiconductors (<em>e.g.</em>, WSe<sub>2</sub>) is critical for complementary electronics beyond silicon-based technology. While bilayer WSe<sub>2</sub>, indicates superior electrical potential over its monolayer counterpart, owing to reduced contact resistance and suppressed Fermi-level pinning, its scalable synthesis remains challenging due to uncontrolled nucleation and limited understanding of vertical growth mechanisms. Herein, elucidate the atomic-scale pathway of bilayer WSe<sub>2</sub> growth in a molten salt-assisted chemical vapor deposition (CVD) process. Density functional theory (DFT) calculations reveal that WO<sub>2</sub>Cl<sub>2</sub> intermediates promote vertical stacking by cooperatively adsorbing on monolayer template centers, while W<sub>1</sub>Se<sub>1</sub> clusters facilitate epitaxial nucleation. By precisely controlling the Se/WO₃ vapor ratio, we achieve the epitaxial growth of uniform equal-bilayer (EB) WSe<sub>2</sub> with high crystallinity and clean interfaces. Back-gated transistors based on EB- WSe<sub>2</sub> exhibit a high on/off ratio of 10⁷ and a hole mobility of 50.1 cm²V⁻¹s⁻¹ , significantly outperforming the monolayer devices with 14.7-fold enhancement. This work provides a mechanistic foundation for the controlled synthesis of 2D heterostructures and advances the application of 2D semiconductors in post-Moore electronics.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"68 ","pages":"Article 102998"},"PeriodicalIF":10.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical strength and biomechanics of extracellular vesicles 细胞外囊泡的机械强度和生物力学

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-09-27 DOI: 10.1016/j.nantod.2025.102905

Yuewen Zhai , Ji Fang , Fang He , Ziyuan Qin , Jun Liu , Siwen Li

{"title":"Mechanical strength and biomechanics of extracellular vesicles","authors":"Yuewen Zhai , Ji Fang , Fang He , Ziyuan Qin , Jun Liu , Siwen Li","doi":"10.1016/j.nantod.2025.102905","DOIUrl":"10.1016/j.nantod.2025.102905","url":null,"abstract":"<div><div>Extracellular vesicles (EVs) serve as essential mediators of intercellular communication and play a pivotal role in both physiological and pathological processes. Their mechanical strength and biomechanical properties not only dictate structural stability, in vivo delivery efficiency, and biological functionality but also have significant implications for disease diagnosis and targeted therapy. This review systematically summarizes the methodologies and key parameters used to assess the mechanical strength of EVs, and synthesizes current evidence identifying the internal protein network, membrane cholesterol and phospholipid composition, AQP1 and other membrane protein expression levels, and vesicle size differences as primary structural determinants of EV elasticity. Furthermore, the physiological state of the source cells, production processes, and external mechanical forces are also recognized as critical factors shaping EV mechanical properties. In addition, this review comprehensively discusses the adaptive behaviors of EVs with distinct mechanical characteristics in complex biological environments, with a particular focus on their transmembrane transport, circulation dynamics, and targeted delivery capabilities, and delineates the mechanistic principles by which EVs with varying elasticity achieve prolonged circulation and subsequent uptake by recipient cells. Based on recent advances, this review also explores the potential applications of the mechanical properties and biomechanical principles of EVs in quality control assessment, disease diagnostics, and drug delivery, while offering a forward-looking perspective on their future development in the biomedical field.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102905"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactolytic and TGFβ-inhibiting nanoplatform overcomes immunosuppression to enhance radiosensitivity in osteosarcoma 乳酸溶解和tgf β抑制纳米平台克服免疫抑制，增强骨肉瘤的放射敏感性

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-12-09 DOI: 10.1016/j.nantod.2025.102953

Linbang Wang , Jiaruo Tang , Rui Dou , Heng Zhang , Xiaomeng Cai , Yu Liu , Jingkun Liu , Xiaoguang Liu , Jiayu Zhang , Jun Chen

{"title":"Lactolytic and TGFβ-inhibiting nanoplatform overcomes immunosuppression to enhance radiosensitivity in osteosarcoma","authors":"Linbang Wang , Jiaruo Tang , Rui Dou , Heng Zhang , Xiaomeng Cai , Yu Liu , Jingkun Liu , Xiaoguang Liu , Jiayu Zhang , Jun Chen","doi":"10.1016/j.nantod.2025.102953","DOIUrl":"10.1016/j.nantod.2025.102953","url":null,"abstract":"<div><div>Osteosarcoma, the most prevalent malignant bone tumor in adolescents, presents significant clinical challenges due to its aggressive nature and resistance to conventional therapies including radiotherapy. Through analysis of human osteosarcoma specimens, we identified lactate and TGFβ as key regulators of the tumor microenvironment (TME), which collectively induce an immunosuppressive osteosarcoma microenvironment. To address this, we developed a novel multifunctional nanosystem constructed by genetically engineering lactate oxidase (LOX)-anchored platelet membranes to encapsulate manganese dioxide (MnO<sub>2</sub>) nanoparticles and the TGFβ inhibitor SB525334. This system demonstrates tumor-selective accumulation while simultaneously enabling lactate catabolism and TGFβ suppression. In vitro and in vivo studies confirmed that this synergistic approach effectively inhibits TGFβ-mediated signaling pathways and enhances T cell-mediated anti-tumor immunity. Furthermore, combination therapy with PD-L1 blockade significantly suppressed tumor growth and reduced recurrence rates, demonstrating robust adaptive immune responses. These findings highlight the transformative potential of engineered platelet membrane nanosystems in integrating metabolic modulation with immune regulation to improve current osteosarcoma treatment paradigms.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"67 ","pages":"Article 102953"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Layered GaPS4 dielectric for two-dimensional transistors 用于二维晶体管的层状GaPS4介电介质

IF 10.9 1区材料科学

Nano Today Pub Date : 2026-02-01 Epub Date: 2025-10-13 DOI: 10.1016/j.nantod.2025.102915

Liqun Niu , Zhiren Chen , Guorui Xiao , Zhaowei Zhang , Yinning Zhou , Yu Zhou , Huamin Li , Shen Lai

{"title":"Layered GaPS4 dielectric for two-dimensional transistors","authors":"Liqun Niu , Zhiren Chen , Guorui Xiao , Zhaowei Zhang , Yinning Zhou , Yu Zhou , Huamin Li , Shen Lai","doi":"10.1016/j.nantod.2025.102915","DOIUrl":"10.1016/j.nantod.2025.102915","url":null,"abstract":"<div><div>Developing van der Waals (vdW) high-k dielectric layers is a key factor in achieving high-performance two-dimensional (2D) semiconductor field effect transistors (FETs). Here, we experimentally reveal that layered GaPS<sub>4</sub> flakes exhibit a high dielectric constant of up to 35 and a high capacitance density (∼2.95 μF/cm²), along with a bandgap larger than 4.15 eV. Band alignment of MoS<sub>2</sub>/GaPS<sub>4</sub> heterostructure indicates a unipolar-like barrier between MoS<sub>2</sub> and GaPS<sub>4</sub> for electrons of ∼1.92 eV. We employed GaPS<sub>4</sub> as gate dielectric with an equivalent oxide thickness (EOT) of 1 nm in a MoS<sub>2</sub> FET, and the device shows a low gate leakage current of 10<sup>−13</sup> A, a high on/off ratio of ∼3 × 10<sup>8</sup>, and minimal hysteresis (∼20 mV). Theoretical modeling confirms that weak interactions preserve the MoS<sub>2</sub> channel’s inherent electronic properties. Compared to other layered dielectrics, GaPS<sub>4</sub> in MoS<sub>2</sub> FETs demonstrates superior properties in terms of bandgap, dielectric constant, EOT and on/off ratio. These advantages highlight the potential of GaPS<sub>4</sub> for integration into 2D semiconductor FETs.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"66 ","pages":"Article 102915"},"PeriodicalIF":10.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0