Nano Today最新文献

{"title":"A nanoscale innate immune multiplier amplifies immunogenic cell death triggered by oxaliplatin via enhancing systemic and trained immunity","authors":"Yang Zhang ,&nbsp;Zhicheng Yan ,&nbsp;Shuo Geng ,&nbsp;Yueheng Wang ,&nbsp;Junji Ren ,&nbsp;Yunhui Jiang ,&nbsp;Liuqing Yang ,&nbsp;Wenbing Dai ,&nbsp;Hua Zhang ,&nbsp;Xueqing Wang ,&nbsp;Nan Zheng ,&nbsp;Qiang Zhang ,&nbsp;Bing He","doi":"10.1016/j.nantod.2025.102835","DOIUrl":"10.1016/j.nantod.2025.102835","url":null,"abstract":"<div><div>Inducing immunogenic cell death (ICD) of cancer cells is the key for cytotoxic drugs to improve the synergy with immunotherapy. However, due to the immunosuppressive microenvironment and the cytotoxicity differences of drugs, ICD effects are often insufficient and difficult to effectively and durably activate anti-tumor immune responses. Here, we performed a network meta-analysis (NMA) based on clinical data of gastrointestinal cancer and identified oxaliplatin (Oxp) as an effective ICD-inducing drug. Meanwhile, to overcome the negative effects of immunosuppressive microenvironment on ICD, we constructed a nanoscale innate immune multiplier (NIIM) composed of nano-granulated manganous zoledronate, and designed a systemic delivery strategy to achieve the superposition of innate immune responses from multiple sites and amplify the ICD effect of Oxp. NIIM was first targeted to the tumor tissue, where it concurrently engaged tumor cells and innate immunocytes to reverse the immunosuppressive microenvironment. Following intravenous administration, NIIM was also distributed to the spleen, where it activated Ly6C⁺ inflammatory monocytes, directly augmenting the phagocytosis and elimination of tumor cells, and inducing the tumor-killing efficacy by cytotoxic T cells. Additionally, NIIM modulated the composition of hematopoietic progenitor cells in the bone marrow, inducing a durable innate immune response through trained immunity. The superposition of these immune effects allowed NIIM to significantly enhance the efficacy of oxaliplatin in gastrointestinal cancers after only one single injection. In summary, this strategy of simultaneously activating intratumoral, systemic, and trained immunity based on intravenous NIIM provides an effective new approach to amplify ICD of cytotoxic drugs and achieve the efficient synergy of chemotherapy with immunotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102835"},"PeriodicalIF":13.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanostructured heterojunctions for magnetoelectric efficiency enhancement and the wireless electrical stimulation in neurogenesis","authors":"Jialu Li ,&nbsp;Yusheng Zhang ,&nbsp;Xiaoyin Liu ,&nbsp;Yuyan Wang ,&nbsp;Rong Li ,&nbsp;Yiyao Pu ,&nbsp;Junzhong Jiang ,&nbsp;Jiamei Xiao ,&nbsp;Peng Liu ,&nbsp;Jie Ding ,&nbsp;Dan Wei ,&nbsp;Jing Sun ,&nbsp;Chengheng Wu ,&nbsp;Liangxue Zhou ,&nbsp;Roman V. Chernozem ,&nbsp;Hongsong Fan","doi":"10.1016/j.nantod.2025.102833","DOIUrl":"10.1016/j.nantod.2025.102833","url":null,"abstract":"<div><div>Wireless deep brain stimulation mediated by magnetoelectric (ME) nanoparticles (NPs) has emerged as a promising alternative to traditional neuromodulation for neurological disorders. However, it is a great challenge to achieve a highly efficient treatment of neural injuries via limited ME conversion efficiency, which highlights the opportunity for further material optimization. Here, we propose a robust strategy to improve the ME efficiency by introducing Au NPs onto the surface of core<img>shell CoFe₂O₄@BaTiO₃ NPs to build Schottky junctions, thereby promoting the separation of electron<img>hole pairs. Moreover, Schottky junctions can be modulated by the piezoelectric field generated by the piezoelectric shell of ME NPs under a magnetic field, allowing electrons to flow continuously. On this basis, we established a wireless ME modulation platform by integrating heterojunction-reinforced ME NPs with a hydrogel matrix that mimics key biochemical and mechanical properties of neural tissue, supporting long-term magnetoelectric stimulation of neural stem cells (NSCs) and promoting their neuronal differentiation <em>in vitro</em>. Furthermore, the therapeutic potential of the ME platform was demonstrated in a traumatic brain injury (TBI) model, in which it significantly enhanced NSC migration and neuronal differentiation, promoted the reconstruction of neural networks, and improved cognitive and memory functions. Overall, this strategy provides new insights for the development of brain stimulation strategies as well as neural tissue repair following injury.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102833"},"PeriodicalIF":13.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Back Cover - Graphical abstract TOC/TOC in double column continued from OBC if required, otherwise blank page","authors":"","doi":"10.1016/S1748-0132(25)00199-9","DOIUrl":"10.1016/S1748-0132(25)00199-9","url":null,"abstract":"","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102827"},"PeriodicalIF":13.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outside Back Cover - Graphical abstract TOC/TOC in double column/Cover image legend if applicable, Bar code, Abstracting and Indexing information","authors":"","doi":"10.1016/S1748-0132(25)00200-2","DOIUrl":"10.1016/S1748-0132(25)00200-2","url":null,"abstract":"","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"64 ","pages":"Article 102828"},"PeriodicalIF":13.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanogels confined superactive LOx-CPO for TME-responsive enzyme-gene therapy","authors":"Xueting Liu ,&nbsp;Dingze Zhou ,&nbsp;Yuxi Zhang ,&nbsp;Zonghui Zhao ,&nbsp;Wenhao Zhao ,&nbsp;Xia Wang ,&nbsp;Qigang Wang","doi":"10.1016/j.nantod.2025.102821","DOIUrl":"10.1016/j.nantod.2025.102821","url":null,"abstract":"<div><div>Tumor cells, due to their reliance on aerobic glycolysis, contribute to the tumor microenvironment (TME), which is characterized by lactate accumulation and redox imbalances. Targeting lactate, a key metabolic substrate in the TME, a novel strategy combining gene therapy with enzyme dynamic therapy (EDT) has been proposed. This strategy utilizes a cascade oxidase-peroxidase system, which induces tumor DNA damage while simultaneously inhibiting repair mechanisms. By mimicking the construction of multienzyme complexes, a highly active and well-ordered oxidase-peroxidase and gene platform (ASO-miR21/DLC-NGs) has been developed. The platform is based on dextran-confined lactate oxidase (LOx) and chloroperoxidase (CPO) pairs, followed by small molecule monomer-induced diffusion-controlled self-terminating polymerization for efficient loading of Antisense Oligonucleotide targeting microRNA-21 (ASO-miR21). By precisely regulating the dimensions (nanoscale to microscale) and crosslinking density, this approach overcomes the limitations of traditional multi-enzyme systems, such as poor stability and inefficient substrate diffusion. The synergistic effects of DNA damage and anti-repair are achieved by catalytically regulating reactive oxygen species (ROS), which reverses the redox balance and downregulates miR21 expression, inhibiting tumor cell proliferation. The catalytic transformation research of metabolic substrates of abnormal tumor microenvironment and the multi-pathway design with the metabolic regulation can provide important insights for specialized or interdisciplinary researchers on the multipathway cancer therapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102821"},"PeriodicalIF":13.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocatalytic antioxidation synergizes cardioprotection and antifibrosis in cardiac injury","authors":"Ruixuan He ,&nbsp;Bowen Yang ,&nbsp;Jianlin Shi","doi":"10.1016/j.nantod.2025.102820","DOIUrl":"10.1016/j.nantod.2025.102820","url":null,"abstract":"<div><div>Myocardial injury and fibrosis are two important features of acute cardiac ischemia, both lead to heart failure. Clinical data indicate that targeting myocardial injury or fibrosis alone are not sufficient to improve myocardial infraction patient prognosis. Notably, reactive oxygen species (ROS) play a critical role in both myocardial injury and fibrosis, through disrupting redox homeostasis within cardiomyocytes, and mediating profibrotic signaling within fibroblasts as well. Herein, a nanocatalytic antioxidative therapeutic methodology is developed for synergistic treatment of post-ischemic cardiac injury, by using zeolitic imidazolate framework-67 nanoparticles (ZIF-67 NPs) as paradigmatic antioxidative nanocatalysts, to efficiently scavenge ROS for concurrent cardioprotection and antifibrosis. ZIF-67 NPs are capable of efficiently catalyzing hydrogen peroxide disproportionation owing to the enriched Co-N₄ active sites, which can restore redox homeostasis in cardiomyocytes to inhibit apoptosis/ferroptosis. More intriguingly, the catalytic ROS-scavenging effect can further suppress redox signaling within fibroblasts to inhibit their transition to myofibroblast. In vivo results further demonstrate the significant efficacy of nanocatalytic antioxidation for cardioprotection and antifibrosis. This study provides a feasible approach for synergistic treatment of post-ischemic cardiac injury by nanocatalytic antioxidation.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102820"},"PeriodicalIF":13.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of optimizing cellular uptake and excretion of nanoparticles by aggregation and de-aggregation mediated size changes","authors":"Miao Feng ,&nbsp;Stefan Werner ,&nbsp;Bing Qi ,&nbsp;Jinrui Li ,&nbsp;Florian Schulz ,&nbsp;Wolfgang J. Parak","doi":"10.1016/j.nantod.2025.102819","DOIUrl":"10.1016/j.nantod.2025.102819","url":null,"abstract":"<div><div>Gold nanoclusters of around 1.7 nm diameter were encapsulated in a matrix of the biodegradable polymer poly-L-arginine (PLAG), leading to nanoparticles (NPs) of around 70 nm diameter. It was shown that in order to achieve the same amount of endocytosed Au after 24 h exposure of HeLa cells to the NPs, for the encapsulated nanoclusters around 3 times less Au needed to be added to the cells, minimizing the necessary exposure concentration. On the other hand, due to the degradability of the PLAG, the intracellular Au could be exocytosed by around 3.5 times faster than for non-degradable Au NPs of similar initial size. This study thus quantified the effect of size-variable NPs on endo- and exocytosis. Aggregation of small NPs to bigger NPs in biodegradable matrices allows for improved endocytosis. De-aggregation of endocytosed aggregated NPs upon degradation of the biodegradable matrix allows for improved exocytosis, which is an important prerequisite for NPs clearance from cells, avoiding long-term toxicity.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102819"},"PeriodicalIF":13.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the morphology-driven pathogenicity of nanofibers through proteomic profiling","authors":"Tobias Stobernack ,&nbsp;Antje Vennemann ,&nbsp;Dirk Broßell ,&nbsp;Oliver Gräb ,&nbsp;Mario Pink ,&nbsp;Andrea Haase ,&nbsp;Martin Wiemann ,&nbsp;Verónica I. Dumit","doi":"10.1016/j.nantod.2025.102812","DOIUrl":"10.1016/j.nantod.2025.102812","url":null,"abstract":"<div><div>The shape and durability of inhalable fibers is connected with their potential to cause lung cancer. Especially toxicological effects of nanofibers and their derivatives are still incompletely understood. Currently, their safety evaluation is performed under <em>in vivo</em> settings. However, as nanofiber applications continue to expand, alternative approaches are urgently needed that align with the 3 R principles (Replacement, Reduction, Refinement). To this end, silicon carbide (SiC) and titanium dioxide (TiO₂) nanofibers as well as their ground fragments were tested in the NR8383 alveolar macrophage assay. Intact nanofibers induced dose-dependent cytotoxicity, oxidative stress, and the release of pro-inflammatory cytokines, while their ground counterparts elicited minimal effects. The subsequent proteomic profiling of cells exposed to a sub-cytotoxic nanofiber concentration revealed significant alterations in the levels of 32 % (SiC) and 8 % (TiO₂) of all detected proteins compared to untreated cells. Besides protein modifications induced by oxidative stress, key alterations comprised protein clusters attributed to inflammation (n_proteins=9), vesicular trafficking (n = 22), metabolic changes (n = 32) and apoptosis (n = 5). Cells treated with equal amounts of ground nanofibers exhibited only negligible changes, highlighting the morphology-driven nature of the effects. Finally, a set of 58 proteins are proposed as a proteomic fingerprint of nanofiber-related toxicity at the cellular level. Overall, the study substantiates fiber morphology-driven effects of nanofibers in alveolar macrophages and outlines concrete protein biomarkers to describe nanofiber pathogenicity along with underlying mechanisms. This work contributes to the development of a robust <em>in vitro</em> testing strategy required for the Safe-and-Sustainable-by-Design demand of the European Commission.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102812"},"PeriodicalIF":13.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered nanoparticle transformations: Rethinking toxicity in water","authors":"Mikołaj Feculak ,&nbsp;Susana Loureiro ,&nbsp;Jason C. White ,&nbsp;Baoshan Xing ,&nbsp;Kevin C.-W. Wu ,&nbsp;Mohamed Salah Sheteiwy ,&nbsp;Yanzheng Gao ,&nbsp;Patryk Oleszczuk ,&nbsp;Izabela Jośko","doi":"10.1016/j.nantod.2025.102804","DOIUrl":"10.1016/j.nantod.2025.102804","url":null,"abstract":"<div><div>The burgeoning production and utilization of engineered nanoparticles (ENPs) in recent years has precipitated the intentional and inadvertent discharge of ENPs into the environment, where undergo different transformations. Extensive research has investigated the mechanisms underlying the environmental transformations of metal-based ENPs, with a focus on alterations in the properties of their transformation products. It is widely recognized that ENP-biota interactions are influenced by various ENP characteristics, such as size, shape, surface area, chemical composition, surface charge, and chemistry. As a result of transformations, changes in ENP properties are anticipated to affect biotic interactions, including cellular recognition and trafficking, thus impacting organismal responses. This hypothesis has only recently been subjected to experimental scrutiny, mainly within simplified ENP-organism systems. Major studies indicate that the acute toxicity of transformed ENPs is largely driven by the rate and yield of metal ion release, similar to pristine ENPs. However, when transformations reduce ENP dissolution, they may enhance environmental persistence, rendering other toxicity mechanisms more significant. We meticulously examine available data on the toxicity of various transformed ENPs, aiming to systematically assess the actual responses of aquatic biota concerning altered ENP properties and differing environmental factors. In this context, we highlight scenarios involving multiple ENP transformations and specific local environmental modifications. These research directions warrant further exploration, especially under real-world conditions. Such efforts will expand the database, which, through the application of modern machine learning and artificial intelligence tools, can aid in predicting the fate of ENPs released from the increasing array of nano-products.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102804"},"PeriodicalIF":13.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breathable palladium hydride hydrogels mediated “head and tail” co-blocking HMGB1-RAGE axis strategy for diabetic foot ulcer treatment","authors":"Weidi Wang ,&nbsp;Xueling Liu ,&nbsp;Jiali Xiao ,&nbsp;Yunning Zhang ,&nbsp;Yu Hao ,&nbsp;Ruidong Hou ,&nbsp;Liang Fang ,&nbsp;Qing You ,&nbsp;Yilin Song","doi":"10.1016/j.nantod.2025.102815","DOIUrl":"10.1016/j.nantod.2025.102815","url":null,"abstract":"<div><div>Diabetes patients suffer from severe chronic consequences known as diabetic foot ulcers (DFUs), for which there are no particular therapy options. The inflammatory and oxidative microenvironments in DFUs stimulate the secretion of high mobility group box-1 (HMGB1), which binds with the receptor of advanced glycation endproducts (RAGE), causing inflammatory cascade reactions and immune microenvironment (IME) disorder, further exacerbating DFUs damage. Strategies targeting the HMGB1-RAGE axis to end this vicious loop are still lacking. This study proposes a novel strategy based on “breathable hydrogels” to achieve HMGB1-RAGE axis “head and tail” co-blocking to regulate the IME for DFUs treatments. Specifically, with palladium hydride (PdH) nanocubes as the functional structure, a hydrogel dressing was prepared from a double cross-linking network of biocompatible alginate and polyacrylamide and modified with trehalose as the network-repairing agent. Mechanistically, the obtained hydrogels can “inhale” the excess accumulated reactive oxygen species, inhibiting HMGB1 secretion, the “head” of the HMGB1-RAGE axis. Meanwhile, H₂ “exhaled” from the hydrogels can suppress the expression of intracellular RAGE, thus blocking the HMGB1-RAGE axis and breaking the vicious cycle. The proposed “head and tail” co-blocking strategy based on “breathable hydrogels” offers a highly efficient, safe, and facile therapeutic protocol for DFUs.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"65 ","pages":"Article 102815"},"PeriodicalIF":13.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}