Nano Today最新文献

{"title":"PDMS-based photothermal super-ice-repellent films with bendable stretchability and efficient anti-icing/de-icing properties","authors":"Chen Yang ,&nbsp;Yifan Liu ,&nbsp;Shangzhen Xie ,&nbsp;Zhiguang Guo","doi":"10.1016/j.nantod.2025.102704","DOIUrl":"10.1016/j.nantod.2025.102704","url":null,"abstract":"<div><div>Superhydrophobic surfaces exhibit excellent ice delay performance, but ice formation still occurs under prolonged low-temperature conditions. In this paper, the blending stability of PDMS and nano-TiN and EG particles is utilized, combined with laser processing strategy to form an array-distributed micron-scale papillary structure, to prepare a photothermal flexible superhydrophobic film that is stretchable/bendable and has excellent anti-wetting. After 100 bending and stretching deformations, the SH-PDMS@TiN@EG flexible film still maintains excellent water repellency, with water contact angles of 159 ± 1° (bending) and 157 ± 1° (stretching) and rolling angles of 3.7 ± 0.5° (bending) and 5 ± 0.5° (stretching). Under 1 sun illumination, the SH-PDMS@TiN@EG flexible film can reach a saturation temperature of 63.7 °C. Under low-temperature conditions (-10℃), the SH-PDMS@TiN@EG flexible film exhibits an excellent ice delay time (2826 s, promoting homogeneous nucleation of droplets) and a fast photothermal melting/deicing time (0.5 sun, 57 s). Cables coated with SH-PDMS@TiN@EG flexible film can achieve stable anti-icing and fast photothermal deicing in low temperature environments. Large droplets (0.4 ml) frozen on the surface of the film can fall off in 263 s under 0.5 sun solar radiation. The film has good anti-frost (-10 ℃, delayed frost time is 3018 s) and defrost time (1 sun, 98 s). The SH-PDMS@TiN@EG flexible film has good mechanical durability and can maintain good water repellency in icing-deicing cycles and impact tests. This work provides new ideas for the research of photothermal superhydrophobic film materials, which will be promising for anti-icing/de-icing in the fields of power transmission, aircraft, ships, and road traffic.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102704"},"PeriodicalIF":13.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of buffer layer in epitaxial growth of TMDCs","authors":"Dechun Zhou ,&nbsp;Wenjin Gao ,&nbsp;Andrew Thye Shen Wee ,&nbsp;Miao Zhou ,&nbsp;Tianchao Niu","doi":"10.1016/j.nantod.2025.102718","DOIUrl":"10.1016/j.nantod.2025.102718","url":null,"abstract":"<div><div>This review explores the pivotal role of buffer layers in unidirectional alignment growth of TMDC. We highlight recent experimental and theoretical insights into atomic-scale interfacial structures. Strategies to optimize growth conditions are discussed through integration of vacuum-interconnected systems and machine learning.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102718"},"PeriodicalIF":13.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refined platelet size: Unlocking enhanced mechanics in nacre-mimetic mineralized materials","authors":"Wei Chen ,&nbsp;Yuanyuan Ma ,&nbsp;Shiqing Xu ,&nbsp;Yang Wang ,&nbsp;Pengchao Zhang ,&nbsp;Jingxin Meng ,&nbsp;Zhengyi Fu ,&nbsp;Shutao Wang","doi":"10.1016/j.nantod.2025.102722","DOIUrl":"10.1016/j.nantod.2025.102722","url":null,"abstract":"<div><div>Nacre-mimetic mineralized (NMM) materials with outstanding mechanical properties have been considered as future structural materials. However, replicating nacre's characteristics into artificial ones in mild conditions has been challenging, particularly in controlling the platelet size, which is crucial for mechanical performance. Here, inspired by mollusk biomineralization, we achieve the unprecedented regulation of aragonite platelet sizes (ranging from 76 to 5800 μm²) at the micrometer scale by manipulating amorphous nano calcium carbonate content, thereby enhancing the mechanical properties of NMM materials. Experimental and simulation results demonstrate that merely decreasing the aragonite platelets' sizes can significantly increase the flexural strength and modulus by 2.8 and 9.9 times, respectively. Notably, the proposed strategy not only has the potential for large-scale production but also produces refined NMM material that closely resembles natural nacre in terms of microstructure and mechanical properties, showing ca. 26 % improvement in specific strength over previously reported NMM materials. Consequently, this work provides a feasible way for developing advanced biomimetic structural materials with specific functions, such as protective gear and artificial bone grafts.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102722"},"PeriodicalIF":13.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of pyroptosis and immunogenic cell death by targeted liposomal cisplatin for enhanced chemo-immunotherapy for osteosarcoma","authors":"Jingyou Bi ,&nbsp;Yuchen Han ,&nbsp;Xinli Han ,&nbsp;Yanan Wu ,&nbsp;Song Liao ,&nbsp;Yinglong Zhang ,&nbsp;Xiaolu Han ,&nbsp;Zengming Wang ,&nbsp;Jianxiong Li ,&nbsp;Aiping Zheng ,&nbsp;Wenzhi Bi","doi":"10.1016/j.nantod.2025.102717","DOIUrl":"10.1016/j.nantod.2025.102717","url":null,"abstract":"<div><div>Low delivery efficiency and accompanying systematic toxicity of therapeutic agents have affected the efficacy of chemotherapy for osteosarcoma (OS). Meanwhile, the chemotherapy based on cisplatin, as the single modality, has reached the limits. Here, we designed a liposome nanotheranostic platform that combined cisplatin with decitabine to simultaneously activate the pyroptosis and immunogenic cell death in an effective delivery manner. Specifically, we prepared the targeted liposomal therapeutics (NPCD@ALN). NPCD@ALN effectively accumulated at the bone lesion induced by OS <em>in vivo</em>. Meanwhile, NPCD@ALN released NPCD and ALN when reaching the acidic tumor microenvironment, thus the charge reversing from negative to positive and enabling the better endocytosis of NPCD. NPCD activated caspase-3 to cleave GSDME into pore-forming GSDME-N terminal, letting the cancer cell release pro-inflammatory factors into the extracellular microenvironment. Subsequently, the released inflammatory cytokines promoted the maturation of antigen-presenting cells, the infiltration of cytotoxic T cells and the remodeling of immunosuppressive microenvironment. Eventually, NPCD triggered pyroptosis and immunogenic cell death and evoked the adaptive immune response to realize the powerful synergistic chemotherapy and immunotherapy for osteosarcoma. To summarize, this study exemplified rational therapeutics which facilitated the activation of pyroptosis and antitumor immune response by targeted liposomal cisplatin, and provided innovative combined-therapeutic strategies for osteosarcoma.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102717"},"PeriodicalIF":13.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on nanobodies in the diagnosis and treatment of natural toxin poisoning","authors":"Xiwei Wang ,&nbsp;Zenglin Yin ,&nbsp;Nan Liu ,&nbsp;Hui Zhang ,&nbsp;Zengming Wang ,&nbsp;Jinjing Che ,&nbsp;Jianchun Li ,&nbsp;Aiping Zheng","doi":"10.1016/j.nantod.2025.102711","DOIUrl":"10.1016/j.nantod.2025.102711","url":null,"abstract":"<div><div>Natural toxins pose a substantial threat to human health worldwide, with millions of individuals suffering from toxin poisoning annually. Rapid detection and efficient neutralization of these toxins are crucial to ensure human health. Nanobodies (Nbs) are a unique antibody type comprising only variable region fragments of the heavy chain. With properties such as small size, high stability, superior tissue penetration, and ease of production and modification, making Nbs are particularly advantageous in the diagnosis and treatment of natural toxin poisoning. This review outlines the current advancements in the modification of Nbs and highlights the research progress in addressing the diagnosis and treatment of poisoning caused by certain natural toxins. It underscores the potential of Nbs in this field, while also examining their benefits and associated challenges. By doing so, the study lays a robust groundwork for the future application of Nbs in combating natural toxin poisoning. Nbs could play an increasingly important role in diagnosing and treating natural toxin poisoning, contributing to the development of precision medicine.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102711"},"PeriodicalIF":13.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal responsive vesicle-INFγ aptamer-PEI/HA system targeted activation of B-CD4T-Tfh-CD8T cells cascade inhibits TNBC progression","authors":"Qi Liang ,&nbsp;Yunbo Luo ,&nbsp;Jiao Zeng ,&nbsp;Shiqi Han ,&nbsp;Yali Wang ,&nbsp;Xiaohan Su ,&nbsp;Xue Li ,&nbsp;Tingting Liang ,&nbsp;Jun Liu ,&nbsp;Peng Qu ,&nbsp;Jiao Shi ,&nbsp;Jinsui Li ,&nbsp;Cui Ma ,&nbsp;Kaijiong Zhang ,&nbsp;Shishan Deng ,&nbsp;Dongsheng Wang ,&nbsp;Panke Cheng ,&nbsp;Lingmi Hou","doi":"10.1016/j.nantod.2025.102708","DOIUrl":"10.1016/j.nantod.2025.102708","url":null,"abstract":"<div><div>Like other tumors, triple-negative breast cancer (TNBC) exhibits immune evasion characteristics, but the activation of an appropriate immune cascade can effectively suppress TNBC progression. This article focuses on enhancing the cytotoxicity of CD8 T cells as an entry point. In TNBC patients and immunodeficient mouse models, it was found that the proportions of specific CD95^hiGL7^hiB (acB), CD44^hiCD69^hiCD4 T (acCD4 T), CD44^hiICOS^hiPSGL1^loPD1^hi CXCR5^hiBCL6^hiTfh (acTfh), and PD1^hiGranzyme B^hiCD8 T (acCD8 T) cells are negatively correlated with tumor progression. Based on the pathological features of localized hypoxia and high lysyl hydroxylase 2(LH2) expression in TNBC, and utilizing the oxygen concentration responsiveness of nitroimidazoles, the homing targeting of cell-derived vesicles, the proteolytic activity of LH2 enzyme on substrate peptides, and the targeted inhibitory effect of nucleic acid aptamers, based on a temporal response strategy, this article designs a composite system of acTfh and primary TNBC cells derived vesicles, interferon gamma (INF-γ) aptamer, hyaluronic acid and polyethyleneimine. This system encapsulates co-stimulatory antigens for acB, acCD4 T, and acCD8 T cells, along with an interleukin 21 (IL21) overexpression plasmid. It can sequentially respond to hypoxia, LH2 enzyme, and IFNγ in TNBC tissues, thereby targeting the promotion of antigen secretion by TNBC cells, activating and expanding acB, acCD4 T, and acCD8 T cells. It activates acB to promote the differentiation of acCD4 T into acTfh cells, inhibits the tumor-promoting escape function of IFNγ produced by acCD4 T cells, targets the promotion of IL21 secretion by acTfh cells, and ultimately activates the cytotoxicity of acCD8 T cells to kill tumor cells. The temporal response strategy of this composite nanosystem offers a potential new approach for the immune treatment of TNBC in the future.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102708"},"PeriodicalIF":13.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143641150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunochemotherapeutic nanoparticles inhibit cancer-promoting fibroblasts subtypes for pancreatic ductal adenocarcinoma","authors":"Xiangyu Chu ,&nbsp;Dongqi Li ,&nbsp;Xiaocui Fang ,&nbsp;Fuming Liang ,&nbsp;Ping Li ,&nbsp;Qing You ,&nbsp;Chen Wang ,&nbsp;Ling Zhu ,&nbsp;Yanlian Yang ,&nbsp;Yinmo Yang ,&nbsp;Xiaodong Tian","doi":"10.1016/j.nantod.2025.102709","DOIUrl":"10.1016/j.nantod.2025.102709","url":null,"abstract":"<div><div>Cancer-associated fibroblasts (CAFs) and immunosuppressive microenvironment play important roles in the progression of pancreatic ductal adenocarcinoma (PDAC). Myofibroblast CAFs (myCAFs) and antigen-presenting CAFs (apCAFs) are cancer-promoting fibroblast (CPF) subtypes which could promote dense extracellular matrix (ECM) formation to inhibit drug penetration and induce the immunosuppressive microenvironment. The inhibition of CPF subtypes may help improve the PDAC treatment efficacy. Herein the engineered CPF-inhibiting nanoparticles are constructed with BSA-MnO₂-Niclosamide nanoparticles coated with exosomes encapsulating gemcitabine (BMN/GEM@PE) to substantially inhibit the progression and liver metastasis of PDAC by inhibiting the STAT3/p-STAT3 signals. The nanoparticles could significantly reduce the proportion of cancer-promoting CAF subtypes (myCAFs and apCAFs), which induce a shift from immune \"cold\" tumor to \"hot\" tumor phenotype. The reduced myCAFs by nanoparticles could promote the drug penetration and the infiltration of CD8⁺ T cells, and the decreased apCAFs lead to the decrease of the regulatory T cells. The new nanoparticles-based treatment strategies that the CAFs-subtypes modulation may influence the tumor immune microenvironment, which provide an opportunity to improve the immunochemotherapy for PDAC.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102709"},"PeriodicalIF":13.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143641149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cruciferae-based oral selenium delivery system reprograms antitumor response and enhances the anti-tumor potency of natural killer cells","authors":"Shuoshan Li,&nbsp;Guizhen Li,&nbsp;Kexin Guo,&nbsp;Lin Zhou,&nbsp;Haimei Zhang,&nbsp;Haoqiang Lai,&nbsp;Tianfeng Chen","doi":"10.1016/j.nantod.2025.102713","DOIUrl":"10.1016/j.nantod.2025.102713","url":null,"abstract":"<div><div>Natural killer (NK) cell-based immunotherapy represents a promising approach for lung cancer treatment, but its clinical efficacy is limited by poor <em>in vivo</em> persistence and cytotoxicity. Selenium, an essential trace element with immunomodulatory and antitumor properties, offers therapeutic potential, but its application is constrained by low bioavailability. In this study, Chinese Kale (<em>Brassica oleracea</em> var. <em>alboglabra</em>, <em>BOA</em>) was used to construct an oral kale seedlings biotransformation nano-selenium delivery system (Se@<em>BOA</em>). By inducing mitochondrial apoptosis in tumor cells, Se@<em>BOA</em> could effectively reprogram non-small-cell lung cancer immune resistance and enhance the killing abilities of NK cells on A549 cells <em>in vitro</em>, and additionally promote the activation of innate immune cells as well as adoptive NK cells to lyse tumors <em>in vivo</em>. Further mechanistic studies demonstrated that Se@<em>BOA</em> sensitizes tumor cells to NK cells by triggering DNA damage and p53 signaling pathways to induce NKG2DLs and death receptor expression. Additionally, Se@<em>BOA</em> could activate the AHR-STAT3 signaling cascade and promote NKG2D and NKp44 receptor expression on NK cells and thus inhibit tumor immune escape. Taken together, these findings reveal a novel strategy to improve selenium bioavailability and enhance the antitumor efficacy of allogenic human NK cell infusions, potentially informing the development of a plant-derived oral selenium delivery system to support NK cell therapy against lung cancer.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102713"},"PeriodicalIF":13.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143641699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracellular in-situ activated enzyme/prodrug strategy based on tris(triazole)-Cu+ complex for cooperative catalytic cancer therapy","authors":"Tian Qiu ,&nbsp;Lan Yang ,&nbsp;Yupeng Zhu ,&nbsp;Jiajia Wang ,&nbsp;Ziyi Li ,&nbsp;Xinlei Gao ,&nbsp;Qi Shen ,&nbsp;Jiumeng Zhang ,&nbsp;Fengting Lv ,&nbsp;Xuli Feng","doi":"10.1016/j.nantod.2025.102715","DOIUrl":"10.1016/j.nantod.2025.102715","url":null,"abstract":"<div><div>Simultaneously delivering enzymes and prodrugs to the target sites is an attractive anticancer strategy. In this work, we demonstrate that triskelion lysine containing a tris(triazole)-Cu⁺ complex (TLTC) can be employed to concurrently load horseradish peroxidase (HRP) and a prodrug (indole-3-acetic acid, IAA) within a single TLTC nanoparticle. This design utilizes Cu⁺-mediated HRP inhibition to prevent premature activation of IAA, addressing a critical limitation in conventional HRP/IAA systems. Due to the responsion of Cu⁺ to H₂O₂, the HRP/IAA system is activated by the high-concentration H₂O₂ in tumors to generate reactive oxygen species (ROS) for killing tumor cells. The controlled activation of the HRP/IAA system within the tumor microenvironment, mediated by Cu⁺/H₂O₂ interaction, represents a significant advancement over conventional enzyme/prodrug therapies. Moreover, the self-supply of H₂O₂ from the HRP/IAA reaction and the Fenton reaction mediated by Cu⁺/Cu²⁺ redox cycling further amplifies the therapeutic effect, creating a self-sustaining cycle of ROS production. This dual mechanism of ROS generation, combining enzyme/prodrug activation and Fenton effect, significantly improves therapeutic outcomes. Thus, our triskelion-based architectures offer the opportunity to activate the enzyme/prodrug therapy (EPT) within the tumor mass while evading systemic toxicity, which represents a promising strategy for developing novel EPT based on triskelion peptide self-assembly.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102715"},"PeriodicalIF":13.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143641148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembly Mn-R837 nanosheet sensitized hollow prussian blue for STING activation and ferroptosis co-enhanced sono-immunotherapy","authors":"Nan Wang ,&nbsp;Xiaoyu Fu ,&nbsp;Yanan Wu ,&nbsp;Lang Yan ,&nbsp;Xinyi Zhao ,&nbsp;Jinfeng Li ,&nbsp;Bijiang Geng ,&nbsp;Jiaming Guo ,&nbsp;Jikuai Chen","doi":"10.1016/j.nantod.2025.102716","DOIUrl":"10.1016/j.nantod.2025.102716","url":null,"abstract":"<div><div>Promoting the maturation of dendritic cells (DCs) play crucial roles in the effectiveness of activating of adaptive immune response. However, the immunosuppressive tumor microenvironments (TME) are thought to impede DC maturation and inhibit antigen presentation, significantly reducing the therapeutic efficacy of immunotherapy. Herein, to realize the cascade activation of DC maturation, we report the first time the integration of reactive oxygen species (ROS)/ferroptosis-mediated immunogenic cell death (ICD) effect, cGAS-STING activation, and tumor-specific delivery of immune adjuvants. To demonstrate this technique, we utilized FDA-approved hollow Prussian Blue (HPB) with good sonodynamic and chemodynamic activities as the template for the self-assembly of Mn-R837. HPB/Mn-R837 not only possesses enhanced US-activated ROS generation capability owing to the construction of heterojunctions, but also exhibits TME-responsive degradation behaviors, achieving the tumor-specific release of Fe^2 +, Fe³⁺, Mn²⁺, Mn⁴⁺, and R837. HPB/Mn-R837-triggered cascade activation of DC maturation were elucidated, including (1) heterojunction fabrication, GSH consumption, and in-situ CDT co-amplified ROS generation as well as ferroptosis could significantly induce robust ICD effect; (2) activation of the cGAS-STING pathway by the released Mn²⁺ serves to stimulate DC maturation; (3) direct promotion of DC maturation can be achieved by the tumor-specific released R837. As a result, significant antitumor effects have been discovered to completely eradicate primary tumors and effectively inhibit the growth of distant tumors without side effects. This work establishes a novel strategy for the integration of ROS/ferroptosis-induced ICD effect, STING activation, and tumor-specific delivery of immune adjuvants into a single nanostructure for establishing lasting and effective immune responses.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102716"},"PeriodicalIF":13.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}