工程技术最新文献

{"title":"Neuroenhancement by repetitive transcranial magnetic stimulation (rTMS) on DLPFC in healthy adults.","authors":"Elias Ebrahimzadeh, Seyyed Mostafa Sadjadi, Mostafa Asgarinejad, Amin Dehghani, Lila Rajabion, Hamid Soltanian-Zadeh","doi":"10.1007/s11571-024-10195-w","DOIUrl":"10.1007/s11571-024-10195-w","url":null,"abstract":"<p><p>The term \"neuroenhancement\" describes the enhancement of cognitive function associated with deficiencies resulting from a specific condition. Nevertheless, there is currently no agreed-upon definition for the term \"neuroenhancement\", and its meaning can change based on the specific research being discussed. As humans, our continual pursuit of expanding our capabilities, encompassing both cognitive and motor skills, has led us to explore various tools. Among these, repetitive Transcranial Magnetic Stimulation (rTMS) stands out, yet its potential remains underestimated. Historically, rTMS was predominantly employed in studies focused on rehabilitation objectives. A small amount of research has examined its use on healthy subjects with the goal of improving cognitive abilities like risk-seeking, working memory, attention, cognitive control, learning, computing speed, and decision-making. It appears that the insights gained in this domain largely stem from indirect outcomes of rehabilitation research. This review aims to scrutinize these studies, assessing the effectiveness of rTMS in enhancing cognitive skills in healthy subjects. Given that the dorsolateral prefrontal cortex (DLPFC) has become a popular focus for rTMS in treating psychiatric disorders, corresponding anatomically to Brodmann areas 9 and 46, and considering the documented success of rTMS stimulation on the DLPFC for cognitive improvement, our focus in this review article centers on the DLPFC as the focal point and region of interest. Additionally, recognizing the significance of theta burst magnetic stimulation protocols (TBS) in mimicking the natural firing patterns of the brain to modulate excitability in specific cortical areas with precision, we have incorporated Theta Burst Stimulation (TBS) wave patterns. This inclusion, mirroring brain patterns, is intended to enhance the efficacy of the rTMS method. To ascertain if brain magnetic stimulation consistently improves cognition, a thorough meta-analysis of the existing literature has been conducted. The findings indicate that, after excluding outlier studies, rTMS may improve cognition when compared to appropriate control circumstances. However, there is also a considerable degree of variation among the researches. The navigation strategy used to reach the stimulation site and the stimulation location are important factors that contribute to the variation between studies. The results of this study can provide professional athletes, firefighters, bodyguards, and therapists-among others in high-risk professions-with insightful information that can help them perform better on the job.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"34"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiplex CRISPR/Cas9-mediated genome editing to address drought tolerance in wheat.","authors":"Naglaa A Abdallah, Hany Elsharawy, Hamiss A Abulela, Roger Thilmony, Abdelhadi A Abdelhadi, Nagwa I Elarabi","doi":"10.1080/21645698.2022.2120313","DOIUrl":"10.1080/21645698.2022.2120313","url":null,"abstract":"<p><p>Genome editing tools have rapidly been adopted by plant scientists for crop improvement. Genome editing using a multiplex sgRNA-CRISPR/Cas9 genome editing system is a useful technique for crop improvement in monocot species. In this study, we utilized precise gene editing techniques to generate wheat 3'(2'), 5'-bisphosphate nucleotidase (<i>TaSal1</i>) mutants using a multiplex sgRNA-CRISPR/Cas9 genome editing system. Five active <i>TaSal1</i> homologous genes were found in the genome of Giza168 in addition to another apparently inactive gene on chromosome 4A. Three gRNAs were designed and used to target exons 4, 5 and 7 of the five wheat <i>TaSal1</i> genes. Among the 120 Giza168 transgenic plants, 41 lines exhibited mutations and produced heritable <i>TaSal1</i> mutations in the M₁ progeny and 5 lines were full 5 gene knock-outs. These mutant plants exhibit a rolled-leaf phenotype in young leaves and bended stems, but there were no significant changes in the internode length and width, leaf morphology, and stem shape. Anatomical and scanning electron microscope studies of the young leaves of mutated <i>TaSal1</i> lines showed closed stomata, increased stomata width and increase in the size of the bulliform cells. <i>Sal1</i> mutant seedlings germinated and grew better on media containing polyethylene glycol than wildtype seedlings. Our results indicate that the application of the multiplex sgRNA-CRISPR/Cas9 genome editing is efficient tool for mutating more multiple TaSal1 loci in hexaploid wheat.</p>","PeriodicalId":54282,"journal":{"name":"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain","volume":" ","pages":"1-17"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33490173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial capping agents on silver nanoparticles made via green method using natural products from banana plant waste.","authors":"Jimmy K Kabeya, Nadège K Ngombe, Paulin K Mutwale, Justin B Safari, Gauta Gold Matlou, Rui W M Krause, Christian I Nkanga","doi":"10.1080/21691401.2025.2462335","DOIUrl":"10.1080/21691401.2025.2462335","url":null,"abstract":"<p><p>Herein, we investigated the phytochemical composition and antibacterial activities of the organic layers from biosynthesized silver nanoparticles (AgNPs). AgNPs were synthesized using <i>Musa paradisiaca</i> and <i>Musa sapientum</i> extracts. UV-vis absorption in the 400-450 nm range indicated surface plasmonic resonance peak of AgNPs. Samples analyses using dynamic light scattering and transmission electron microscopy revealed the presence of particles within nanometric ranges, with sizes of 30-140 nm and 8-40 nm, respectively. Fourier transform infrared (FTIR) unveiled the presence of several organic functional groups on the surface of AgNPs, indicating the presence of phytochemicals from plant extracts. Thin layer chromatography (TLC) of the phytochemicals (capping agents) from AgNPs identified multiple groups of secondary metabolites. These phytochemical capping agents exhibited antibacterial activities against <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Pseudomonas aeruginosa</i>, with minimum inhibitory concentrations ranging from 62.5 to 1000 µg/mL. Regardless of the bacterial species or plant parts (leaves or pseudo-stems), capping agents from <i>M. sapientum</i> nanoparticles displayed significantly enhanced antibacterial effectiveness compared to all other samples, including the raw plant extracts and biosynthesized capped and uncapped AgNPs. These results suggest the presence of antimicrobial phytochemicals on biosynthesized AgNPs, highlighting the promise of green nanoparticle synthesis as a valuable approach in bioprospecting antimicrobial agents.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"29-42"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of MicroRNA-31 with Endometrial Receptivity in Patients with Repeated Implantation Failure of <i>In Vitro</i> Fertilization and Embryo Transfer.","authors":"Yan Tan, Bijun Du, Xixi Chen, Minhong Chen","doi":"10.1080/15476278.2025.2460263","DOIUrl":"10.1080/15476278.2025.2460263","url":null,"abstract":"<p><strong>Objective: </strong>This trial probed the correlation between miR-31 expression and endometrial receptivity (ER) in patients with repeated implantation failure (RIF) of in vitro fertilization and embryo transfer (IVF-ET).</p><p><strong>Methods: </strong>A retrospective study of 80 infertility patients who underwent IVF-ET assisted conception treatment were divided into RIF group and normal pregnancy group (control group) according to the pregnancy outcome after embryo transfer. General information of both groups was collected. Endometrial tissues were collected in the middle luteal phase of the menstrual cycle before IVF-ET. miR-31 levels in endometrial tissues were measured, and endometrial tolerance indicator pulsatility index (PI), resistance index (RI), and endometrial thickness (Em) were detected. The correlation between endometrial miR-31 levels and ER indices was evaluated by Pearson method. ROC curves were utilized to analyze the efficacy of miR-31 in predicting RIF occurrence. The influencing factors of RIF were analyzed by binary Logistic regression.</p><p><strong>Results: </strong>RIF patients had increased miR-31 expression level and endometrial tolerance indicator PI, and RI while decreased Em (<i>p</i> < 0.05). miR-31 in RIF patients was positively correlated with PI and RI, and negatively correlated with Em (<i>p</i> < 0.05). The area under the curve for miR-31 to predict the occurrence of RIF was 0.899, with a sensitivity of 0.750 and a specificity of 0.950. PI, RI, and miR-31 were risk factors for developing RIF in IVF-ET women, and Em was a protective factor (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>miR-31 in RIF patients is positively correlated with PI and RI, and negatively correlated with Em.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"21 1","pages":"2460263"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesis of silver nanoparticles for functional cotton fabrics: antimicrobial efficacy against multidrug-resistant bacteria and cytotoxicity evaluation.","authors":"Sérgio Antunes Filho, Clara M Almeida, Maria Teresa Villela Romanos, Bianca Pizzorno Backx, Raquel Regina Bonelli","doi":"10.1080/21691401.2025.2485115","DOIUrl":"https://doi.org/10.1080/21691401.2025.2485115","url":null,"abstract":"<p><p>Bacterial infections associated with healthcare are a challenge on a global scale due to the high morbidity and mortality rates, especially those caused by multidrug-resistant isolates. Hospital textiles are abiotic surfaces that may serve as a means of disseminating and persisting microorganisms in hospitals, as microorganisms can remain viable on these surfaces for up to months. In this study, we employed a green synthesis approach utilizing guava leaf extract (<i>Psidium guajava</i>) to produce silver nanoparticles, which were then incorporated into a cotton fabric. Antimicrobial properties and the cytotoxicity of the functional textile were assessed. The finding indicated that the green synthesis method was efficient and resulted in a predominant population of nanoparticles with diameters ranging from 25 to 84 nm that were uniformly dispersed in the textile. The functional textile exhibited low toxicity and high antimicrobial efficiency, even against multidrug-resistant microorganisms of particular concern in hospital settings. Atomic force microscopy carried out evidenced invaginations in the cell wall of bacteria submitted to this textile, suggesting surface damage as an important mechanism of action silver nanoparticles incorporated.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"153-165"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvesicles and exosomes isolated from murine bone marrow-derived mesenchymal stromal cells primed with p38MAPK inhibitor differentially regulate hematopoietic stem cell function.","authors":"Pallavi Budgude, Vaijayanti Kale, Anuradha Vaidya","doi":"10.1080/21691401.2025.2475095","DOIUrl":"https://doi.org/10.1080/21691401.2025.2475095","url":null,"abstract":"<p><p>The signaling mechanisms active within mesenchymal stromal cells (MSCs) influence the composition of microvesicles (MVs) and exosomes (Exos) secreted by them. Previously, we showed that priming MSCs with a p38 pharmacological inhibitor (pMSCs) rejuvenates them and improves their ability to promote <i>ex vivo</i> hematopoietic stem cell (HSC) expansion. This study examined whether pMSCs exerted HSC-supportive ability via MVs (pMVs) and Exos (pExos). Our findings demonstrate distinct regulation of HSC fate by pMVs and pExos. pMVs promoted the expansion of long-term HSCs (LT-HSCs), distinguished by their robust self-renewal capacity and superior engraftment ability. In contrast, pExos facilitated expansion of short-term HSCs (ST-HSCs) with high proliferative and differentiation potential. Infusing a combination of pMVs- and pExos-expanded HSCs as a composite graft resulted in significantly higher HSC engraftment, emphasizing the synergistic interaction between LT- and ST-HSC populations. Gene expression studies, functional and phenotypic experiments showed that pMVs regulate HSC quiescence via the <i>Egr1/Cdkn1a</i> axis, while pExos control HSC proliferation via the <i>Nfya/Cdkn1a</i> axis. These findings provide insights into the molecular mechanisms underlying the differential regulation of HSC function by pMVs and pExos. It also proposes a composite graft strategy of using pMVs and pExos as \"MSC-derived biologics\" for improving the HSC transplantation success.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"122-137"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dynamic impact of adult neurogenesis on pattern separation within the dentate gyrus neural network.","authors":"Kai Yang, Xiaojuan Sun, Zengbin Wang","doi":"10.1007/s11571-025-10244-y","DOIUrl":"10.1007/s11571-025-10244-y","url":null,"abstract":"<p><p>Pattern separation in the dentate gyrus (DG) is crucial for distinguishing similar memories. The DG continues to undergo neurogenesis throughout the lifespan, and adult hippocampus neurogenesis leads to the incorporation of thousands of adult-born granule cells (adult-born GCs) into the existing DG circuitry. These newborn GCs exhibit high excitability and are easier to respond to novel stimuli, which seems to be contrary to the requirement of pattern separation for high input specificity. Meanwhile, the changes brought about by the growth of adult-born GCs can not be ignored. Here, we build a biologically relevant model of the DG containing adult-born GCs and test it using the Modified National Institute of Standards and Technology (MNIST) database. By analyzing this model, the results show that the net effect of adult-born GCs to GCs is inhibition, thereby improving the sparsity of GCs and pattern separation. This provides computational evidence for \"indirect encoding\" of adult-born GCs. In addition, as adult-born GCs transition toward maturity, they have the following growth characteristics: decreased activity, increased coupling strength with feedback inhibition, and enhanced synaptic plasticity. We find that the decreased activity reduces pattern separation efficiency while the other characteristics increase pattern separation efficiency. Finally, given that the firing rate of entorhinal cortex (EC) neurons is influenced by numerous factors (such as the complexity of memory tasks), the input frequency to the DG should be within a range rather than being fixed. To address this, we gradually increase the input frequency and notice that the presence of adult-born GCs increases the adaptability of the DG neural network and thus improves the robustness of pattern separation.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"57"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrated <i>in vitro</i> and <i>in silico</i> approach to assess targeted cytotoxicity against MDA-MB-231 triple-negative breast cancer cells with <i>Psidium guajava</i> peel-derived chitosan nanoparticles.","authors":"Vino Udappusamy, Rajan Thinagaran, Vijayakumar Mayakrishnan, Janani Balakarthikeyan, Priya Kannappan, Sameer Al-Ghamdi, Naif Abdurhman Alrudian, Mohammed Saad Alqahtani, Khalid Albasheer, Chandrabose Sureka, Mahmoud H El-Bidawy, Nesreen Alsanousi, Sahar Gamil, Thiyagarajan Ramesh","doi":"10.1080/21691401.2025.2462333","DOIUrl":"https://doi.org/10.1080/21691401.2025.2462333","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) is a significant global health issue, with high mortality rates. The chemotherapeutic drugs currently used for TNBC have significant side effects, impacting both normal and cancer cells. In this study, we investigated a potential use of fruit peel extract of <i>Psidium guajava</i> (PGP) encapsulated with chitosan nanoparticles (CSNPs) to combat TNBC. The synthesized PGP-CSNPs were characterized using UV-vis spectroscopy, Fourier transform infra-red (FTIR) spectroscopy, TEM and GC-MS. The maximum loading capacity and encapsulation efficacy of PGP-CSNPs were found to be 72.5 ± 0.49% and 92.9 ± 0.10%, respectively. Furthermore, <i>in vitro</i> cytotoxicity was assessed, and the IC₅₀ value for PGP-CSNPs was 50.13 µg/mL. It was observed that PGP-CSNPs could induce apoptosis in MDA-MB-231 cells in dose-dependent manner. Furthermore, molecular docking was performed for bioactive compounds retrieved from PGP-CSNPs against human tumour suppressor proteins Bcl2, and results showed that the PGP-CSNPs had lower binding energy than cisplatin. This suggests that, the synthesized PGP-CSNPs have the potential to serve as a therapeutic agent for tackling TNBC. However, to validate its efficacy in human therapy, furthermore pre-clinical and clinical procedures should be examined, as this is an ongoing and significant step towards developing an effective and safe anticancer drug.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"43-55"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ClaPEPCK4: target gene for breeding innovative watermelon germplasm with low malic acid and high sweetness.","authors":"Congji Yang, Jiale Shi, Yuanyuan Qin, ShengQi Hua, Jiancheng Bao, Xueyan Liu, Yuqi Peng, Yige Gu, Wei Dong","doi":"10.1080/21645698.2025.2452702","DOIUrl":"10.1080/21645698.2025.2452702","url":null,"abstract":"<p><p>Malic acid markedly affects watermelon flavor. Reducing the malic acid content can significantly increase the sweetness of watermelon. An effective solution strategy is to reduce watermelon malic acid content through molecular breeding technology. In this study, we measured the TSS and pH of six watermelon varieties at four growth nodes. The TSS content was very low at 10 DAP and accumulated rapidly at 18, 26, and 34 DAP. Three phosphoenolpyruvate carboxykinase (<i>PEPCK</i>) genes of watermelon were identified and analyzed. The <i>ClaPEPCK4</i> expression was inversely proportional to malate content variations in fruits. In transgenic watermelon plants, overexpressing the <i>ClaPEPCK4</i> gene, malic acid content markedly decreased. In the knockout transgenic watermelon plants, two SNP mutations and one base deletion occurred in the <i>ClaPEPCK4</i> gene, with the malic acid content in the leaves increasing considerably and the PEPCK enzyme activity reduced to half of the wild-type. It is interesting that the <i>ClaPEPCK4</i> gene triggered the closure of leaf stomata under dark conditions in the knockout transgenic plants, which indicated its involvement in stomatal movement. In conclusion, this study provides a gene target <i>ClaPEPCK4</i> for creating innovative new high-sweetness watermelon varieties.</p>","PeriodicalId":54282,"journal":{"name":"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain","volume":"16 1","pages":"156-170"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of transcutaneous auricular vagus nerve stimulation (taVNS) on motor planning: a multimodal signal study.","authors":"Long Chen, Yihao Hu, Zhongpeng Wang, Lei Zhang, Chuxiang Jian, Shengcui Cheng, Dong Ming","doi":"10.1007/s11571-025-10220-6","DOIUrl":"10.1007/s11571-025-10220-6","url":null,"abstract":"<p><p>Motor planning plays a pivotal role in daily life. Transcutaneous auricular vagus nerve stimulation (taVNS) has been demonstrated to enhance decision-making efficiency, illustrating its potential use in cognitive modulation. However, current research primarily focuses on behavioral and single-modal electrophysiological signal, such as electroencephalography (EEG) and electrocardiography (ECG). To investigate the effect of taVNS on motor planning, a total of 21 subjects were recruited for this study and were divided into two groups: active group (n = 10) and sham group (n = 11). Each subject was required to be involved in a single-blind, sham-controlled, between-subject end-state comfort (ESC) experiment. The study compared behavioral indicators and electrophysiological features before and following taVNS. The results indicated a notable reduction in reaction time and an appreciable increase in the proportion of end-state comfort among the participants following taVNS, accompanied by notable alterations in motor-related cortical potential (MRCP) amplitude, low-frequency power of HRV (LF), and cortico-cardiac coherence, particularly in the parietal and occipital regions. These findings show that taVNS may impact the brain and heart, potentially enhancing their interaction, and improve participants' ability of motor planning.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"35"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}