Chinese Herbal Medicines最新文献

{"title":"Modulative effect of Physalis alkekengi on both gut bacterial and fungal micro-ecosystem","authors":"Yanan Yang ,&nbsp;Xiaohui Zhao ,&nbsp;Yong Xie ,&nbsp;Chongming Wu","doi":"10.1016/j.chmed.2023.02.003","DOIUrl":"10.1016/j.chmed.2023.02.003","url":null,"abstract":"<div><h3>Objective</h3><p>Gut microbiome is an intricate micro-ecosystem mediating the human health and drug efficacy. <em>Physalis alkekengi</em> (PAL) is an edible and time-honored traditional Chinese medicine. Several pharmacological effects of PAL have been verified and gut bacteria are implied in its therapeutic actions. However, the detailed modulation of PAL on gut bacterial species and on gut fungi remains largely unknown. We, therefore, designed a preliminary experiment in normal mice to reveal the modulation effect of PAL on both gut bacteria and fungi, and explore the interaction between them.</p></div><div><h3>Methods</h3><p>Herein, the aqueous extract of PAL was orally administrated to normal C57BL/6 mice for four weeks. The full-length 16S rRNA and ITS1/2 gene sequencing were explored to detect the taxa of gut bacteria and gut fungi after PAL treatment, respectively.</p></div><div><h3>Results</h3><p>Oral administration of PAL notably enriched anti-inflammatory bacterial species such as <em>Duncaniella</em> spp. and <em>Kineothrix alysoides</em>, whereas decreased pro-inflammatory species such as <em>Mucispirillum schaedleri</em>. Simultaneously, PAL increased the abundance of gut fungi <em>Aspergillus ochraceus</em>, <em>Cladosporium</em> sp. and <em>Alternaria</em> sp., and decreased <em>Penicillium janthinellum</em>. Correlation network analysis identified two co-existing microbial groups (groups 1 and 2) that were negatively associated with each other. The group 1 comprised PAL-enriched bacteria and fungi, while group 2 was mainly normal chow-enriched bacteria and fungi. In group 1, <em>Antrodia monomitica</em>, <em>Aspergillus clavatus</em>, <em>Mortierella kuhlmanii</em> and <em>Sarcinomyces</em> sp. MA 4787 were positively correlated with <em>Bifidobacterium globosum</em>, <em>Romboutsia ilealis</em> and so on. In group 2, <em>Chaetomium subspirilliferum</em>, <em>Septoria orchidearum</em> and <em>Cephaliophora tropica</em> were positively related to <em>Lactobacillus</em> spp.</p></div><div><h3>Conclusion</h3><p>Altogether, this preliminary study first demonstrated the modulation effect of PAL on both gut bacteria and gut fungi, which may shed light on the elucidation of PAL’s pharmacological mechanism.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 4","pages":"Pages 564-573"},"PeriodicalIF":3.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000473/pdfft?md5=0a45b635820a35d8842cfb666f287ef0&pid=1-s2.0-S1674638423000473-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45607524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Dark tea: A popular beverage with possible medicinal application” [Chinese Herbal Medicines 15 (2023) 3315036]","authors":"Hongjing Pan ,&nbsp;Miaomiao Le ,&nbsp;Chunnian He ,&nbsp;Chung S. Yang ,&nbsp;Tiejun Ling","doi":"10.1016/j.chmed.2023.03.001","DOIUrl":"10.1016/j.chmed.2023.03.001","url":null,"abstract":"","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 4","pages":"Page 614"},"PeriodicalIF":3.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000175/pdfft?md5=06d462fb90f25fc3babfb1bcdcb7203f&pid=1-s2.0-S1674638423000175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41617016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natto: A medicinal and edible food with health function","authors":"Chunfang Wang ,&nbsp;Jinpeng Chen ,&nbsp;Wenguo Tian ,&nbsp;Yanqi Han ,&nbsp;Xu Xu ,&nbsp;Tao Ren ,&nbsp;Chengwang Tian ,&nbsp;Changqing Chen","doi":"10.1016/j.chmed.2023.02.005","DOIUrl":"10.1016/j.chmed.2023.02.005","url":null,"abstract":"<div><p>Natto is a soybean product fermented by natto bacteria. It is rich in a variety of amino acids, vitamins, proteins and active enzymes. It has a number of biological activities, such as thrombolysis, prevention of osteoporosis, antibacterial, anticancer, antioxidant and so on. It is widely used in medicine, health-care food, biocatalysis and other fields. Natto is rich in many pharmacological active substances and has significant medicinal research value. This paper summarizes the pharmacological activities and applications of natto in and outside China, so as to provide references for further research and development of natto.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 349-359"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9941915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cassiae Semen improves non-alcoholic fatty liver disease through autophagy-related pathway","authors":"Mingning Ding ,&nbsp;Fei Zhou ,&nbsp;Yijie Li ,&nbsp;Chuanyang Liu ,&nbsp;Yiqing Gu ,&nbsp;Jianzhi Wu ,&nbsp;Guifang Fan ,&nbsp;Yajing Li ,&nbsp;Xiaojiaoyang Li","doi":"10.1016/j.chmed.2022.09.006","DOIUrl":"https://doi.org/10.1016/j.chmed.2022.09.006","url":null,"abstract":"<div><h3>Objective</h3><p><em>Cassiae Semen</em> (CS, Juemingzi in Chinese) has been used for thousands of years in ancient Chinese history for relieving constipation, improving liver function as well as preventing myopia. Here we aimed to elucidate the anti-steatosis effect and underlying mechanism of CS against non-alcoholic fatty liver disease (NAFLD).</p></div><div><h3>Methods</h3><p>High-performance liquid chromatography (HPLC) was used to identify the major components of CS water extract. Mice were fed with a high-fat and sugar-water (HFSW) diet to induce hepatic steatosis and then treated with CS. The anti-NAFLD effect was determined by measuring serum biomarkers and histopathology staining. Additionally, the effects of CS on cell viability and lipid metabolism in oleic acid and palmitic acid (OAPA)-treated HepG2 cells were measured. The expression of essential genes and proteins involved in lipid metabolism and autophagy signalings were measured to uncover the underlying mechanism.</p></div><div><h3>Results</h3><p>Five compounds, including aurantio-obtusin, rubrofusarin gentiobioside, cassiaside C, emodin and rhein were simultaneously identified in CS extract. CS not only improved the diet-induced hepatic steatosis <em>in vivo</em>, as indicated by decreased number and size of lipid droplets, hepatic and serum triglycerides (TG) levels, but also markedly attenuated the OAPA-induced lipid accumulation in hepatocytes. These lipid-lowering effects induced by CS were largely dependent on the inhibition of fatty acid synthase (FASN) and the activation of autophagy-related signaling, including AMP-activated protein kinase (AMPK), light chain 3-II (LC3-II)/ LC3-1 and autophagy-related gene5 (ATG5).</p></div><div><h3>Conclusion</h3><p>Our study suggested that CS effectively protected liver steatosis via decreasing FASN-related fatty acid synthesis and activating AMPK-mediated autophagy, which might become a promising therapeutic strategy for relieving NAFLD.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 421-429"},"PeriodicalIF":3.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49702981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perilla frutescens: A traditional medicine and food homologous plant","authors":"Xinling Wu ,&nbsp;Shuting Dong ,&nbsp;Hongyu Chen ,&nbsp;Miaoxian Guo ,&nbsp;Zhiying Sun ,&nbsp;Hongmei Luo","doi":"10.1016/j.chmed.2023.03.002","DOIUrl":"https://doi.org/10.1016/j.chmed.2023.03.002","url":null,"abstract":"<div><p><em>Perilla frutescens</em>, an annual herb of the Labiatae family, has been cultivated in China for more than 2000 years. <em>P. frutescens</em> is the one of the first medicinal and edible plant published by the Ministry of Health. Its leaves, stems and seeds can be used as medicine and edible food. Because of the abundant nutrients and bioactive components in this plant, <em>P. frutescens</em> has been studied extensively in medicine, food, health care and chemical fields with great prospects for development. This paper reviews the cultivation history, chemical compositions and pharmacological activities of <em>P. frutescens</em>, which provides a reference for the development and utilization of <em>P. frutescens</em> resources.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 369-375"},"PeriodicalIF":3.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49756908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research and application of leek roots in medicinal field","authors":"Huaijian Wang ,&nbsp;Ying Tian ,&nbsp;Hao Tan ,&nbsp;Mengru Zhou ,&nbsp;Miao Li ,&nbsp;Yuchen Zhi ,&nbsp;Yanbin Shi ,&nbsp;Xuefeng Li","doi":"10.1016/j.chmed.2023.05.002","DOIUrl":"10.1016/j.chmed.2023.05.002","url":null,"abstract":"<div><p>Some Chinese herbs have been used to prevent and treat diseases, and are also used as common food ingredients. These Chinese herbs are potential resource for research and development of new drugs. Leek roots is a typical medicine of food and medicine continuum. It has a long history of medicinal applications and edible food in China. In this paper, the origin, biological active components, pharmacological action and clinical application of leek roots were introduced. We hope that this review will contribute to the development of leek roots for pharmaceutical research and clinical applications, as well as related health products.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 391-397"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9935819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An online automatic sorting system for defective Ginseng Radix et Rhizoma Rubra using deep learning","authors":"Qilong Xue ,&nbsp;Peiqi Miao ,&nbsp;Kunhong Miao ,&nbsp;Yang Yu ,&nbsp;Zheng Li","doi":"10.1016/j.chmed.2023.01.001","DOIUrl":"https://doi.org/10.1016/j.chmed.2023.01.001","url":null,"abstract":"<div><h3>Objective</h3><p>To establish a deep-learning architecture based on faster region-based convolutional neural networks (Faster R-CNN) algorithm for detection and sorting of red ginseng (<em>Ginseng Radix</em> et <em>Rhizoma Rubra</em>) with internal defects automatically on an online X-ray machine vision system.</p></div><div><h3>Methods</h3><p>A Faster R-CNN based classifier was trained with around 20 000 samples with mean average precision value (mAP) of 0.95. A traditional image processing method based on feedforward neural network (FNN) obtained a bad performance with the accuracy, recall and specificity of 69.0%, 68.0%, and 70.0%, respectively. Therefore, the Faster R-CNN model was saved to evaluate the model performance on the defective red ginseng online sorting system.</p></div><div><h3>Results</h3><p>An independent set of 2 000 red ginsengs were used to validate the performance of the Faster R-CNN based online sorting system in three parallel tests, achieving accuracy of 95.8%, 95.2% and 96.2%, respectively.</p></div><div><h3>Conclusion</h3><p>The overall results indicated that the proposed Faster R-CNN based classification model has great potential for non-destructive detection of red ginseng with internal defects.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 447-456"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49838742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phyllanthi Fructus: A modal medicinal and food homologous item in quality evaluation","authors":"Gefei Li ,&nbsp;Yurou Jiang ,&nbsp;Dingkun Zhang ,&nbsp;Li Han ,&nbsp;Taigang Mo ,&nbsp;Sanhu Fan ,&nbsp;Haozhou Huang ,&nbsp;Junzhi Lin","doi":"10.1016/j.chmed.2022.10.006","DOIUrl":"https://doi.org/10.1016/j.chmed.2022.10.006","url":null,"abstract":"<div><p><em>Phyllanthi Fructus</em> is a highly unique medicine and food homologous item, which exhibits distinctive flavor, notable nutritional value, and abundant pharmacological activity. It has enormous potential in the creation of health products and pharmaceuticals. However, due to the unique laws of quality formation and transfer of <em>Phyllanthi Fructus</em>, its appearance, shape, chemical compositions, nutrients, and sensory flavors are frequently greatly influenced by botanical resources, the processing and storage conditions.<!--> <!-->As a result, the current quality evaluation model is difficult to meet the needs of <em>Phyllanthi Fructus</em> as a medicine and food homologous item in the development of diversified products. This paper constructs the hierarchical utilization mode of <em>Phyllanthi Fructus</em> based on its unique quality formation and transmission laws, explores the quality evaluation model for food-oriented use and medicinal-oriented use, respectively, and systematically describes the quality evaluation idea under diversified application scenarios. This paper aims to serve as a reference for the construction of a quality evaluation model suitable for the medicine and food homologous item of <em>Phyllanthi Fructus</em>.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 360-368"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49846944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteins: Neglected active ingredients in edible bird’s nest","authors":"Man Yuan ,&nbsp;Xiaoxian Lin ,&nbsp;Dongliang Wang ,&nbsp;Jianye Dai","doi":"10.1016/j.chmed.2023.02.004","DOIUrl":"10.1016/j.chmed.2023.02.004","url":null,"abstract":"<div><p>Edible bird’s nest (EBN) is a kind of natural invigorant with a long history of consumption in Asia, especially in China. EBN is formed by mixing the saliva of swiftlets (<em>Aerodramus</em>) with feathers and other components during the breeding season. Proteins are the most important nutrient in EBN. By studying proteins in EBN, we can not only elucidate their components at the molecular level, but also study their bioactivities. Therefore, it is of great significance to study the proteins in EBN. Previous research on the proteins in EBN was preliminary and cursory, and no one has summarized and analyzed the proteins in EBN and correlated the bioactivities of these proteins with the biological functions of EBN. This article focused on the proteins in EBN, listed the proteins identified in different proteomic studies, and introduced the sources, structures and bioactivities of the most frequently identified proteins, including acidic mammalian chitinase, lysyl oxidase homolog 3, mucin-5AC, ovoinhibitor, nucleobindin-2, calcium-binding protein (MW: 4.5 × 10⁴) and glucose-regulated protein (MW: 7.8 × 10⁴). The properties of these proteins are closely related to the bioactivities of EBN. Therefore, this article can provide inspiration for further research on the efficacy of EBN.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 383-390"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9941925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three new sesquiterpenes from roots of Curcuma longa","authors":"Jie Zhang ,&nbsp;Xiaorui Ma ,&nbsp;Wei Wang ,&nbsp;Caixia Wu ,&nbsp;Ben Ma ,&nbsp;Chong Yu ,&nbsp;Haifeng Wang","doi":"10.1016/j.chmed.2022.11.007","DOIUrl":"https://doi.org/10.1016/j.chmed.2022.11.007","url":null,"abstract":"<div><h3>Objective</h3><p>To study the chemical constituents from the roots of <em>Curcuma longa</em>.</p></div><div><h3>Methods</h3><p>The structures of the compounds were elucidated based on extensive spectral analysis, including 1D and 2D NMR, MS, UV, and CD analysis.</p></div><div><h3>Results</h3><p>Two new sesquiterpene compounds (1<em>S</em>,2<em>R</em>,5<em>R</em>,7<em>S</em>,8<em>R</em>)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (<strong>1</strong>), (1<em>R</em>,2<em>R</em>,5<em>R</em>,7<em>S</em>,8<em>R</em>)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (<strong>2</strong>), and a new natural product 6-(4-Hydroxymethylphenyl)-2-methyl-hept-2-ene-4-one (<strong>3</strong>) together with three known compounds <em>ar</em>-turmerone (<strong>4</strong>), 2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one (<strong>5</strong>) and 2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one (<strong>6</strong>) were isolated from <em>C. longa</em> root extract with 95% ethanol.</p></div><div><h3>Conclusion</h3><p>In the study, three new compounds were isolated from <em>C. longa</em>, and their absolute configurations were determined.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 470-474"},"PeriodicalIF":3.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49703162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}