Chinese Herbal Medicines最新文献

{"title":"Astragalus polysaccharides inhibit arsenic trioxide-induced BMSCs damage through inhibition of Jnk and p38 signaling pathways","authors":"Wei Wu ,&nbsp;Djibril Bamba ,&nbsp;Zheng Zhang ,&nbsp;Feng Wu ,&nbsp;Yuan Li ,&nbsp;Wenyi Qi ,&nbsp;Yingzhe Liu ,&nbsp;Tingting Zhang ,&nbsp;Ying Su ,&nbsp;Xinyue Wang ,&nbsp;Hongbo Wang ,&nbsp;Shuqin Duan ,&nbsp;Jingwen Ne ,&nbsp;Wenbo Wang ,&nbsp;Jingwei Liu ,&nbsp;Jianyong Tang ,&nbsp;Fengda Li ,&nbsp;Qingchao Wu ,&nbsp;Yang Li ,&nbsp;Fan Yang ,&nbsp;Lei Yang","doi":"10.1016/j.chmed.2025.03.007","DOIUrl":"10.1016/j.chmed.2025.03.007","url":null,"abstract":"<div><h3>Objective</h3><div>Arsenic trioxide (ATO) is a clinically effective anticancer agent used in the treatment of leukemia. However, it exerts adverse effects on non-tumor cells, including bone marrow mesenchymal stem cells (BMSCs). This study aims to investigate the protective role and molecular mechanism of traditional Chinese medicine Astragalus polysaccharides (APS) in mitigating ATO-induced apoptosis in BMSCs.</div></div><div><h3>Methods</h3><div>BMSCs exposed to ATO (0.5 μmol/L) were treated with APS (20, 40, 100, and 200 μg/mL). Cell viability, proliferation, and migration were assessed by using MTT, EdU staining, Transwell, and scratch wound healing assays. Apoptosis was evaluated via TUNEL assay, Hoechst 33258 staining, and flow cytometry. Intracellular reactive oxygen species (ROS) and mitochondrial membrane potential were measured by using DCFH-DA and JC-1 staining. Apoptotic protein expression was analyzed by Western blotting.</div></div><div><h3>Results</h3><div>ATO exposure significantly inhibited the proliferation and migration of BMSCs and induced apoptosis, while APS markedly attenuated the apoptosis of BMSCs induced by ATO, and significantly improved cell proliferation and migration (<em>P</em> &lt; 0.01). Mechanistically, APS effectively reduced ATO-induced ROS (<em>P</em> &lt; 0.01), while the protein expression of Bcl-2-associated X protein (Bax) and cleaved Caspase-3 was significantly decreased (<em>P</em> &lt; 0.05), and the protein expression of Bcl-2 was significantly increased (<em>P</em> &lt; 0.01). In addition, APS markedly decreased the protein expression of c-Jun <em>N</em>-terminal kinase (Jnk) and p38 in ATO-activated BMSCs (<em>P</em> &lt; 0.05), and significantly decreased the protein expression of p16 and p53 (<em>P</em> &lt; 0.01), and increased the protein expression of phosphorylated protein kinase B (p-Akt) and phosphorylated extracellular signal-regulated kinase (p-Erk) (<em>P</em> &lt; 0.01, 0.05).</div></div><div><h3>Conclusion</h3><div>Our study reveals that APS exert significant protective effects against ATO-induced apoptosis in BMSCs. The mechanisms involve suppressing ROS generation, maintaining mitochondrial membrane stability, enhancing cell viability, migration, and proliferation, as well as inhibiting Jnk and p38 mitogen-activated protein kinase (p38 MAPK) signaling pathways. The findings highlight potential molecular targets and novel strategies for the clinical prevention and treatment of ATO-related toxicity<strong><em>.</em></strong></div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"18 1","pages":"Pages 178-187"},"PeriodicalIF":8.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein S-acylation: Pathological mechanisms and novel therapeutic targets for diabetic complications","authors":"Ruiting Liu ,&nbsp;Nuo Xu ,&nbsp;Xuejiao Song ,&nbsp;Yanying Li ,&nbsp;Jie Bu ,&nbsp;Runtao Su ,&nbsp;Hong Guo ,&nbsp;Chen Jiang ,&nbsp;Pengwei Zhuang ,&nbsp;Yanjun Zhang ,&nbsp;Qingsheng Yin","doi":"10.1016/j.chmed.2025.02.009","DOIUrl":"10.1016/j.chmed.2025.02.009","url":null,"abstract":"<div><div>Diabetes involves multi-organ complications that seriously threaten human life and health, and has become a major public health problem of global concern. Unfortunately, clinical management strategies for diabetic complications are still in their “infancy”, restricted by a limited understanding of their complex pathological mechanism. As is well established, lipid metabolism disorder is the characteristic pathological factors of diabetes, but the detailed molecular mechanisms driving the progression of multi-organ complications remain obscure. Protein S-acylation (often referred to as S-palmitoylation) is a reversible lipid modification that reversibly binds fatty acids to protein-specific cysteine (Cys) residues through palmitoyl acyl transferases (PATs, also known as DHHCs) and deacylation enzymes, which is involved in the pathological progression of a variety of complex diseases such as cancer, neurological disorders and metabolic syndrome. Notably, recent studies have shown that protein S-acylation drives the progression of diabetes and its multiple complications, and targeted intervention in the protein S-acylation process significantly alleviates the progression of diabetes and its complications, suggesting that protein S-acylation may be a common pathological link and intervention target of diabetes complications. Therefore, this review systematically comprehends the contribution of protein S-acylation to the progression of diabetes and its complications, summarizes the influence of the diabetic environment on S-acylation related enzymes, as well as providing an in-depth analysis of current drugs, measures, and challenges in targeting S-acylation. Finally, the accessibility of targeting protein S-acylation to prevent diabetes and its complications and the focus of future in-depth studies are envisioned, with a view to providing comprehensive and in-depth references and rationale for future novel strategies targeting protein S-acylation to prevent and treat diabetes and its multi-organ complications.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"18 1","pages":"Pages 110-123"},"PeriodicalIF":8.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbgenomics: Unraveling natural product biosynthesis in traditional Chinese medicine","authors":"Jing Wang ,&nbsp;Jingyuan Song ,&nbsp;Shilin Chen ,&nbsp;Zhichao Xu","doi":"10.1016/j.chmed.2025.11.008","DOIUrl":"10.1016/j.chmed.2025.11.008","url":null,"abstract":"<div><div>Medicinal plants synthesize structurally diverse pharmacologically active natural products through conserved precursor pathways, which are further diversified by lineage-specific tailoring enzymes. Although the biosynthetic pathways of well-studied compounds (e.g., berberine, paclitaxel, and ginsenosides) have been extensively characterized, most bioactive components in Traditional Chinese Medicine (TCM) remain poorly understood. The emerging discipline of Herbgenomics has significantly advanced biosynthetic gene discovery and pathway elucidation. By employing genomics-driven strategies such as biosynthetic gene cluster mining, co-expression analysis, and integrated transcriptome-metabolome profiling, Herbgenomics enables systematic identification of key biosynthetic enzymes and uncovers evolutionary mechanisms (e.g., whole-genome and tandem gene duplications) driving metabolic innovation. Furthermore, it provides a foundation for drug development by leveraging gene-encoded natural diverse components and genome-wide pan-receptor platforms (e.g., pan-GPCR). Through the integration of pathway analysis, regulatory mechanisms, molecular breeding, and synthetic biology, Herbgenomics establishes a comprehensive framework for exploring and engineering TCM natural product biosynthesis, offering a sustainable pathway to the discovery and production of bioactive compounds.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"18 1","pages":"Pages 3-10"},"PeriodicalIF":8.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced applications of synthetic biology technology in biosynthesis of bioactive compounds from medicinal plants","authors":"Yingjun Liu ,&nbsp;Anying Ji ,&nbsp;Haiyang Jia ,&nbsp;Huan Sun","doi":"10.1016/j.chmed.2025.11.006","DOIUrl":"10.1016/j.chmed.2025.11.006","url":null,"abstract":"<div><div>Medicinal plants serve as valuable sources of bioactive compounds with critical applications across pharmaceutical, agricultural, and industrial sectors. Compared to chemical synthesis and plant extraction, synthetic biology offers a green, efficient, and sustainable alternative for producing bioactive compounds, which represents a state of art technology. However, this technology still faces several challenges, including overly long metabolic pathways, inadequate catalytic efficiency of key enzymes in the pathway, and incompatibility between gene elements and host cells, leading to low yields of target bioactive compounds. The development and application of regulatory tools in synthetic biology hold great promise for overcoming these obstacles. This review first summarizes the classification and biosynthesis of bioactive compounds based on structural types. Subsequently, recent advancements are outlined in regulation tools and their application in the heterologous production of bioactive compounds. This review aims to establish a foundation for the efficient production of bioactive compounds based on microbial cell factories. This not only has significant practical implications for reducing the resource consumption and environmental impact of traditional production methods, but also highlights the central role of synthetic biology in promoting the sustainable production of bioactive compounds derived from medicinal plants.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"18 1","pages":"Pages 11-28"},"PeriodicalIF":8.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological, physiological and biochemical changes and effects of polyamines on regulation of Anoectochilus roxburghii during flowering period","authors":"Weiwei Jiang ,&nbsp;Xiaoyun Yan ,&nbsp;Chenfei Lu ,&nbsp;Xiaowei Xu ,&nbsp;Enting Xu ,&nbsp;Dandan Chen ,&nbsp;Yuqiu Huang ,&nbsp;Qingsong Shao ,&nbsp;Aimin Lv","doi":"10.1016/j.chmed.2025.05.007","DOIUrl":"10.1016/j.chmed.2025.05.007","url":null,"abstract":"<div><h3>Objective</h3><div><em>Anoectochilus roxburghii</em> is a valuable medicinal and ornamental plant. The aim of this study is to investigate the morphological and biochemical responses during the flower development stages of <em>A. roxburghii</em>, and to assess the effects of exogenous polyamines (PAs) on bud differentiation and metabolism, thereby providing a theoretical basis for understanding the flowering form and physiology of <em>A. roxburghii</em>.</div></div><div><h3>Methods</h3><div>In this study, morphological and biochemical responses in flower development stages of <em>A. roxburghii</em> were investigated using paraffin sections and stereomicroscope. <em>A. roxburghii</em> was divided into five periods, including vegetative growth period, flower bud period, flowering period, late flowering period and fruiting period. During the flowering phase, specific biochemical parameters were measured, including soluble sugar content, superoxide dismutase (SOD) activity, soluble protein content, peroxidase (POD) activity, and catalase (CAT) activity. These measurements were conducted to understand the biochemical changes occurring within <em>A. roxburghii</em> during its flowering process. Furthermore, the effects of PAs on bud differentiation were examined. Additionally, the activities of <em>S</em>-adenosylmethionine decarboxylase (SAMDC) and polyamine oxidase (PAO), as well as the content of polyphenols, polysaccharides, and flavonoids in <em>A. roxburghii</em>, were measured after PA treatment to evaluate the metabolic changes induced by exogenous PAs.</div></div><div><h3>Results</h3><div>During the flowering phase of <em>A. roxburghii</em>, soluble sugar content and SOD activity were steadily declining. Soluble protein content was initially increasing and then reducing, and POD and CAT activities showed opposite pattern. In addition, the effects of exogenous PAs on bud differentiation were investigated. Results showed that 3 mmol/L putrescine or 0.3 mmol/L spermidine significantly promoted the bud differentiation of <em>A. roxburghii</em> and advanced the flowering. The activities of SAMDC, PAO, and the content of polyphenols, polysaccharides and flavonoids in <em>A. roxburghii</em> significantly increased after PA treatment, demonstrating that exogenous PA can accelerate metabolism and improved the active ingredients content.</div></div><div><h3>Conclusion</h3><div>The flower development of <em>A. roxburghii</em> was divided into five stages, with significant changes in soluble sugar, protein, POD, SOD, CAT, MDA, and PRO levels. Exogenous putrescine and spermidine enhanced bud differentiation and accelerated flowering, increasing SAMDC and PAO activities, suggesting accelerated PA metabolism. PAs also improved active component content. These findings provide a theoretical basis for studying flower morphology and PA-induced flowering regulation of <em>A. roxburghii</em>.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"18 1","pages":"Pages 212-224"},"PeriodicalIF":8.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of proteomics and metabolomics data to understanding of health benefits of tea","authors":"Danicke Willemse,&nbsp;Mariam Rado,&nbsp;Mariska Lilly","doi":"10.1016/j.chmed.2025.11.009","DOIUrl":"10.1016/j.chmed.2025.11.009","url":null,"abstract":"<div><div>Tea is the second most widely consumed non-alcoholic beverage globally. While most teas originate from <em>Camellia sinensis</em> (L.) Kuntze plants, rooibos and honeybush teas are produced from <em>Aspalathus linearis</em> (Burm.f.) R.Dahlgren and <em>Cyclopia</em> species tea plants. Interest in tea and tea-derived components, has increased due to their well-known health benefits. The mechanisms of these health benefits are however poorly understood. Proteomics and metabolomics provide valuable tools to assess the mechanisms of the therapeutic effects of tea in disease treatment. This review summarizes the role played by proteomic and metabolomic studies in investigating the health benefits of <em>C. sinensis</em>, <em>A. linearis,</em> and <em>Cyclopia</em> spp<em>.</em> teas. Surprisingly, no proteomic and metabolomic studies investigating the health benefits of <em>A. linearis</em> and <em>Cyclopia</em> spp<em>.</em> teas and/or their components were identified in a literature search. However, 25 studies using proteomics and 16 studies using metabolomics to investigate the health benefits of <em>C. sinensis</em> teas and/or their components were identified in a literature search. Proteomics and metabolomics have been valuable tools for investigating the health benefits of <em>C. sinensis</em> teas and tea components, and will likely also prove valuable for investigating the effects of <em>A. linearis</em> and <em>Cyclopia</em> spp. teas on human health.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"18 1","pages":"Pages 124-141"},"PeriodicalIF":8.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precise subcellular organelle-targeted analyses of hepatotoxicity of Polygonum multiflorum","authors":"Yijie Li ,&nbsp;Shuni Duan ,&nbsp;Yinhao Zhang ,&nbsp;Runping Liu ,&nbsp;Rong Sun ,&nbsp;Jianzhi Wu ,&nbsp;Zhi Ma ,&nbsp;Xiaojiaoyang Li","doi":"10.1016/j.chmed.2025.03.001","DOIUrl":"10.1016/j.chmed.2025.03.001","url":null,"abstract":"<div><h3>Objective</h3><div>Drug-induced liver injury (DILI) is an undesirable reaction caused by drugs, herbal medicines or supplements and may lead to acute liver failure. <em>Polygoni Multiflori Radix</em> (PMR, Heshouwu in Chinese) originated from the roots of <em>Polygonum multiflorum</em> is a popular traditional Chinese medicine (TCM) while potential hepatotoxicity limits its clinical application. The present study aims to elucidate the in-depth mechanism of PMR-induced organelle heterogeneity of hepatotoxicity.</div></div><div><h3>Methods</h3><div>Network pharmacology and available TCM transcriptomics databases including Integrated Traditional Chinese Medicine (ITCM) and HERB databases were conducted to identify the active ingredients of PMR with the potent ability to injure organelles including microsome, mitochondria, endoplasmic reticulum (ER), Golgi apparatus (GA), and lysosome. Organelles were isolated and cultured with adenosine triphosphate (ATP)-supplemented system. Western blotting and particle size characterization techniques were further performed to clarify the organelle heterogeneity of PMR-induced hepatotoxicity.</div></div><div><h3>Results</h3><div>Five representative organelles were isolated from mouse livers or hepatocytes and administrated with PMR-derived active components and monomers. The results of network pharmacology and virtual screening initially identified the components of PMR that may damage different organelles. By combining experimental verification, we found that five organelles studied in this research were the target organelles for flavonoid (FVN)’s affiliated compound quercetin (QC). Mitochondria were damaged mainly by kaempferol, anthraquinone (AQ) and its monomeric components. Meanwhile, QC and emodin showed effective toxicity on endoplasmic reticulum. For microsome, QC remained the most toxic monomer. For Golgi apparatus, <em>trans</em>-stilbene glycosides (<em>trans-</em>SG), AQ and emodin were the major toxic components in PMR. For lysosomes, total-SG, emodin and QC were the major toxic components in PMR.</div></div><div><h3>Conclusion</h3><div>Collectively, our findings revealed the organelle heterogeneity of PMR-induced hepatotoxicity and identified quercetin as a potential toxic component in PMR. This study provides a novel conjunct strategy to screen and discover potential toxic components and shapes the understanding of toxicity warning and clinically safe use of herbal medicines such as PMR.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"18 1","pages":"Pages 153-166"},"PeriodicalIF":8.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chelidonine overcomes P-gp-mediated adriamycin resistance in MCF-7/ADR cells by inhibiting PDGFRβ/PI3K/Akt pathway","authors":"Xiang Zou ,&nbsp;Yuhang Zhang ,&nbsp;Kaili Liu ,&nbsp;Liyue Zhang ,&nbsp;Jianli Li ,&nbsp;Yue Zhang ,&nbsp;Xuerui Zhang ,&nbsp;Lei Yu ,&nbsp;Zhongyuan Qu","doi":"10.1016/j.chmed.2025.01.005","DOIUrl":"10.1016/j.chmed.2025.01.005","url":null,"abstract":"<div><h3>Objective</h3><div>Chemoresistance represents a major obstacle in breast cancer (BC) treatment. Chelidonine could prevent various tumor cell types. However, the effect and mechanism of chelidonine against BC chemotherapy resistance have not been elucidated. This paper aimed to explore the effect and mechanism of chelidonine on BC chemoresistance.</div></div><div><h3>Methods</h3><div>A CCK-8 assay, flow cytometry and fluorescence microscopy were applied to evaluate the resistance reversal effect of chelidonine on MCF-7/ADR cells. The signaling pathways by which chelidonine suppresses BC were predicted by network pharmacology and validated by Western blotting. The chemoresistant reversal mechanism of chelidonine was clarified using platelet-derived growth factor receptor-<em>β</em> (PDGFR<em>β</em>) silencing with small interfering RNA (siRNA), platelet-derived growth factor-BB (PDGF-BB) stimulation, Western blotting and real-time quantitative polymerase chain reaction (RT-qPCR).</div></div><div><h3>Results</h3><div>Chelidonine remarkably reversed adriamycin (ADR) resistance by decreasing P-glycoprotein (P-gp) expression and the efflux of ADR in MCF-7/ADR cells. Additionally, PDGFR<em>β</em> expression in MCF-7/ADR cells was markedly higher than that in MCF-7 cells (<em>P</em> &lt; 0.01), and PDGFR<em>β</em> knockdown prevented P-gp expression and intracellular ADR accumulation. Network pharmacology identified phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) as a primary pathway of chelidonine-inhibiting BC, which was verified by the marked underexpression of phosphorylated kappa B inhibitor protein kinase (p-IKK), phosphorylated inhibitor of nuclear factor-<em>κ</em>B (p-IKB), and nuclear factor-<em>κ</em>B (NF-<em>κ</em>B) and phosphatase and tensin homolog (PTEN) hyperexpression by chelidonine treatment (<em>P</em> &lt; 0.01). Notably, PDGFR<em>β</em> silencing enhanced the inhibitory effect of chelidonine on the activation of the PI3K/Akt pathway. Moreover, chelidonine suppressed PDGF-BB stimulation of the PDGFR<em>β</em>/PI3K/Akt axis.</div></div><div><h3>Conclusion</h3><div>These findings underscore the potential role of PDGFR<em>β</em> in regulating chemotherapy resistance in BC. Chelidonine could effectively overcome the resistance of MCF-7/ADR cells to ADR by targeting the PDGFR<em>β</em>/PI3K/Akt axis. Meanwhile, these findings highlight the potential of chelidonine as a promising natural chemoresistant agent for BC treatment.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"18 1","pages":"Pages 167-177"},"PeriodicalIF":8.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of Siraitia grosvenorii: Applications, breeding, and biosynthesis of mogrosides","authors":"Zuliang Luo ,&nbsp;Yimei Zang ,&nbsp;Jiaxian Su ,&nbsp;Qi Tang ,&nbsp;Limei Pan ,&nbsp;Xiaojun Ma ,&nbsp;Chongnan Wang ,&nbsp;Changming Mo","doi":"10.1016/j.chmed.2025.11.005","DOIUrl":"10.1016/j.chmed.2025.11.005","url":null,"abstract":"<div><div><em>Siraitia grosvenorii</em> is a premier food-medicine homologous species recognised by China’s National Health Commission and produces mogrosides as its primary active component. These compounds exhibit biological activities, including the regulation of blood sugar, fat metabolism, and immune function regulation. They are classified as high-intensity, non-nutritive sweeteners with significant medicinal potential and nutritional value. This review systematically explores the applications of <em>S. grosvenorii</em> in traditional medicine and foods, with a focus on advances in the conservation of germplasm resources and the traditional breeding of elite varieties, mogroside biosynthetic pathways and the characterization of key genes, and synthetic biology platforms for mogroside production. We have identified the low content of mogroside V in <em>S. grosvenorii</em> as the main reason for its limited application. To address this issue, we propose two strategic approaches: enhancing mogroside content <em>in vivo</em> through molecular design breeding and developing three synthetic biology platforms for mogrosides synthesis to increase yields. These solutions offer viable ways to reduce production costs and expand the commercial use of <em>S. grosvenorii</em> medicines and sweeteners.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"18 1","pages":"Pages 59-76"},"PeriodicalIF":8.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic biology empowers development of traditional Chinese medicine","authors":"Chun Li","doi":"10.1016/j.chmed.2025.11.010","DOIUrl":"10.1016/j.chmed.2025.11.010","url":null,"abstract":"","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"18 1","pages":"Pages 1-2"},"PeriodicalIF":8.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}