Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review

IF 4.7 4区医学 Q1 CHEMISTRY, MEDICINAL

Chinese Herbal Medicines Pub Date : 2024-07-01 DOI:10.1016/j.chmed.2023.09.007

Jianying Liu , Binzhi Zhang , Leqi Wang , Shasha Li , Qinqiang Long , Xue Xiao

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Abstract

Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. G. lucidum spores (GLS) are tiny germ cells released from the mushroom cap during the mature stage of growth. They contain all the genetic active substances of G. lucidum. G. lucidum spore oil (GLSO) is a lipid component extracted from broken-walled Ganoderma spores using supercritical CO₂ extraction technology. GLSO contains fatty acids, Ganoderma triterpenes, sterols and other bioactive compounds. Previous studies have demonstrated that GLSO has a wide range of pharmacological properties, including anti-tumor, anti-aging, neuroprotection, immunomodulation, hepatoprotection and modulation of metabolic diseases. This review summarizes the research progress of GLSO over the past two decades in terms of its bioactive components, extraction and processing techniques, pharmacological effects and safety evaluation. This provides a solid foundation for further research and application of GLSO.

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灵芝孢子油的生物活性成分、药理特性和基本机制：综述

灵芝是一种中药真菌，用于保健和疾病治疗的历史悠久。灵芝孢子（GLS）是蘑菇伞在生长成熟阶段释放出的微小生殖细胞。它们含有所有的灵芝基因活性物质。灵芝孢子油（GLSO）是利用超临界二氧化碳萃取技术从破壁灵芝孢子中提取的脂质成分。GLSO 含有脂肪酸、灵芝三萜类、甾醇和其他生物活性化合物。以往的研究表明，GLSO 具有广泛的药理特性，包括抗肿瘤、抗衰老、神经保护、免疫调节、保肝和调节代谢性疾病。本综述总结了过去二十年来 GLSO 在生物活性成分、提取和加工技术、药理作用和安全性评价等方面的研究进展。这为进一步研究和应用 GLSO 提供了坚实的基础。

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来源期刊

Chinese Herbal Medicines CHEMISTRY, MEDICINAL-

CiteScore

4.40

自引率

5.30%

发文量

629

审稿时长

10 weeks