Chinese Herbal Medicines最新文献

{"title":"Mechanism of action of protopanaxadiol ginsenosides on hepatocellular carcinoma and network pharmacological analysis","authors":"Yue Zhou ,&nbsp;Zi Wang ,&nbsp;Shen Ren ,&nbsp;Wei Li","doi":"10.1016/j.chmed.2024.06.002","DOIUrl":"10.1016/j.chmed.2024.06.002","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally, posing a major challenge to global health care. Protopanaxadiol ginsenosides (PDs) have been believed to significantly improve liver diseases. PDs, such as Rg₃, have been developed as a new class of anti-cancer drugs. Ginsenosides Rb₁, Rd, Rg₃, and Rh₂ exhibit effective anti-inflammatory and anti-tumor activities. Studies have confirmed that PDs could be used to treat HCC. However, the mechanism of action of PDs on HCC remains unclear. In the study, we reviewed the anti-HCC effects and mechanisms of PDs including Rb₁, Rd, Rg₃, Rg₅, Rh₂, Rk₁, and Compound K (CK). Then, we searched for relevant targets of PDs and HCC from databases and enriched them for analysis. Subsequently, molecular docking was simulated to reveal molecular mechanisms. We found that PDs may treat HCC through multiple signaling pathways and related targets. PDs could inhibit the proliferation, invasion, and metastasis of HCC while promoting apoptosis and inducing differentiation. In conclusion, this review and network pharmacological analysis might offer a direction for in-depth research on related mechanisms. These insights will aid in the direction of further pharmacological studies and the development of safe and effective clinical drugs.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 4","pages":"Pages 548-557"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative analysis of metabolome and transcriptome provides new insights into functional components of Lilii Bulbus","authors":"Wenjun Wei ,&nbsp;Tao Guo ,&nbsp;Wenguang Fan ,&nbsp;Mengshan Ji ,&nbsp;Yu Fu ,&nbsp;Conglong Lian ,&nbsp;Suiqing Chen ,&nbsp;Wenjing Ma ,&nbsp;Wenfang Ma ,&nbsp;Shuying Feng","doi":"10.1016/j.chmed.2023.10.004","DOIUrl":"10.1016/j.chmed.2023.10.004","url":null,"abstract":"<div><h3>Objective</h3><p><em>Lilium brownii</em> var. <em>viridulum</em> (LB) and <em>L. lancifolium</em> (LL) are the main sources of medicinal lily (<em>Lilii Bulbus</em>, Baihe in Chinese) in China. However, the functional components of these two species responsible for the treatment efficacy are yet not clear. In order to explore the therapeutic material basis of <em>Lilii Bulbus</em>, we selected <em>L. davidii</em> var. <em>willmottiae</em> (LD) only used for food as the control group to analyze the differences between LD and the other two (LB and LL).</p></div><div><h3>Methods</h3><p>Metabolome and transcriptome were carried out to investigate the differences of active components in LD <em>vs</em> LB and LD <em>vs</em> LL. Data of metabolome and transcriptome was analysed using various analysis methods, such as principal component analysis (PCA), hierarchical cluster analysis (HCA), and so on. Differentially expressed genes (DEGs) were enriched through KEGG and GO enrichment analysis.</p></div><div><h3>Results</h3><p>The PCA and HCA of the metabolome indicated the metabolites were clearly separated and varied greatly in LL and LB contrasted with LD. There were 318 significantly differential metabolites (SDMs) in LD <em>vs</em> LB group and 298 SDMs in LD <em>vs</em> LL group. Compared with LD group, the significant up-regulation of steroidal saponins and steroidal alkaloids were detected both in LB and LL groups, especially in LB group. The HCA of transcriptome indicated that there was significant difference in LB <em>vs</em> LD group, while the difference between LL and LD varied slightly. Additionally, 47 540 DEGs in LD <em>vs</em> LB group and 18 958 DEGs in LD <em>vs</em> LL group were identified. Notably, CYP450s involving in the biosynthesis of steroidal saponins and steroidal alkaloids were detected, and comparing with LD, <em>CYP724</em>, <em>CYP710A</em>, and <em>CYP734A1</em> in LB and <em>CYP90B</em> in LL were all up-regulated.</p></div><div><h3>Conclusion</h3><p>This study suggested that steroidal saponins and steroidal alkaloids maybe the representative functional components of <em>Lilii Bulbus</em>, which can provide new insights for <em>Lilii Bulbus</em> used in the research and development of classic famous formula.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 435-448"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000078/pdfft?md5=36e4859dc837025c25ed32688316af0b&pid=1-s2.0-S1674638424000078-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic diversity of food-medicinal Lycium spp. in China: Insights from chloroplast genome","authors":"Ruyu Yao ,&nbsp;Bin Wang ,&nbsp;Michael Heinrich ,&nbsp;Qiuling Wang ,&nbsp;Peigen Xiao","doi":"10.1016/j.chmed.2024.02.003","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.02.003","url":null,"abstract":"<div><h3>Objective</h3><p>Goji (fruits of <em>Lycium</em> spp.) is commonly consumed as food and medicine. The increasing market demand for goji has led to its wide cultivation and broad breeding, which might cause loss of genetic diversity. This study aims to uncover the genetic diversity of the cultivated and wild <em>Lycium</em>.</p></div><div><h3>Methods</h3><p>The chloroplast genome (CPG) of 34 accessions of Chinese food-medicinal <em>Lycium</em> spp., including the popular cultivars and their wild relatives, was re-sequenced and assembled, based on which the genetic diversity was evaluated.</p></div><div><h3>Results</h3><p>Sequence structural comparison shows that CPG is comparatively conserved within species. Phylogenetic analysis indicates that CPG is sufficient for the discrimination of <em>Lycium</em> species; combined with nuclear ribosomal internal transcribed spacer (Nr ITS) sequences, materials with mixed genetic backgrounds can be identified. Nucleotide diversity analysis reveals that the modern cultivars are probably with a common maternal parent, while the wild accessions are with higher level of genetic diversity.</p></div><div><h3>Conclusion</h3><p>For the first time this study reveals the intraspecies genetic diversity of <em>Lycium</em> spp. using CPG, highlighting the urgent conservation demand of wild genetic resources of <em>Lycium</em>. Our study also demonstrates that CPG provides crucial evidence for identification of <em>Lycium</em> species with mixed genetic backgrounds and highlights the importance of the wild relatives in genetic diversity conservation. This CPG-based technology will contribute to the sustainable development of medicinal plants broadly.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 401-411"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000376/pdfft?md5=cc5496423b5c8e51dc44c581353ef450&pid=1-s2.0-S1674638424000376-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis on patents of health care products with substances of medicine food homology in China","authors":"Haibo Liu ,&nbsp;Yanfeng Wang ,&nbsp;Jiali Huang ,&nbsp;Zhengqi Dong ,&nbsp;Peigen Xiao","doi":"10.1016/j.chmed.2024.03.005","DOIUrl":"10.1016/j.chmed.2024.03.005","url":null,"abstract":"<div><h3>Objective</h3><p>The concept of substances of medicine food homology (SMFH) has garnered significant attention in recent years. This study conducts a systematic analysis of patent literature related to SMFH, and elucidates the development trends, technical hotspots, and the overall patent protection landscape of SMFH in China over the past two decades.</p></div><div><h3>Methods</h3><p>The patent search focused on the SMFH varieties as the objects of inquiry, with retrieval conducted in patent databases. Subsequently, the acquired data underwent processing, analysis, and visualization.</p></div><div><h3>Results</h3><p>While the technical threshold for pharmaceutical applications surpasses that of the food service sector, the former may assume a prominent role in the future. Research and development (R&amp;D) activities in the southeast of China demonstrate robust activity than other regions. Colleges and scientific research institutions exhibit substantial advantages in patent applications compared with individuals and hold greater potential for future development.</p></div><div><h3>Conclusion</h3><p>The findings of this patent analysis indicate that China’s SMFH industry are presently undergoing a transition from an extensive model to a high-quality model. The quality and technical standards of SMFH products are consistently improving. Consequently, there is a need for more stringent patent application requirements to align with the evolving development needs.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 412-421"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000455/pdfft?md5=a235d223dac22c014eec3f7f9990f79b&pid=1-s2.0-S1674638424000455-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141137132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical composition, pharmacological activity and development strategies of Rubus chingii: A review","authors":"Xiangmei Xiong ,&nbsp;Zheng Liu ,&nbsp;Xiance Che ,&nbsp;Xuemin Zhang ,&nbsp;Xia Li ,&nbsp;Wenyuan Gao","doi":"10.1016/j.chmed.2024.01.007","DOIUrl":"10.1016/j.chmed.2024.01.007","url":null,"abstract":"<div><p>Raspberries are used for both food and medicine, but it has not yet attracted widespread attention. In this paper, the chemical constituen of the original plant raspberry. <em>R. chingii</em> is one of the new “Zhe Bawei” medicinal materials selected in 2017. “Zhe Bawei” refers to eight kinds of genuine medicinal materials in Zhejiang Province. The chemical constituents, pharmacological effects, processing, and application of <em>Rubus chingii</em> Hu were reviewed to provide a reference for its further development. Relevant literature in recent years was collected in databases such as China Knowledge Network, Web of Science, Elsevier, PubMed, and X-Mol, using “raspberry”, “<em>Rubus chingii</em>”, “traditional use”, “chemical composition”, “pharmacology”, etc. as keywords individually or in combination. The summary of pharmacological activities shows that the relationship between the pharmacological activities of raspberry is still not deep enough. More in-depth research should be carried out in this direction to explore the mechanism of action of its active ingredients and provide effective reference for the further development of the raspberry industry. In the future, with the participation of more researchers, it is expected to develop innovative drugs based on raspberry for the treatment of diseases.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 313-326"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000480/pdfft?md5=f5c10511ebcf7e1ecf6aae89412b6265&pid=1-s2.0-S1674638424000480-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141142192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constituents from leaves of Macaranga hemsleyana","authors":"Joseph Sakah Kaunda ,&nbsp;Jia Liu ,&nbsp;Yaojun Xu ,&nbsp;Yuansi Chen ,&nbsp;Chenfang Yue ,&nbsp;Xingjie Zhang ,&nbsp;Ruihan Zhang ,&nbsp;Muhammad Amin ,&nbsp;Weilie Xiao ,&nbsp;Hongliang Li ,&nbsp;Xiaoli Li","doi":"10.1016/j.chmed.2023.03.006","DOIUrl":"10.1016/j.chmed.2023.03.006","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;To study constituents of the leaves of &lt;em&gt;Macaranga hemsleyana&lt;/em&gt;, and evaluate their inhibitory effects against NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation, and antiproliferative activity.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;The constituents were isolated and purified by column chromatography on MCI gel CHP20P/P120, silica gel, Sephadex LH-20, and HPLC. The structures of compounds were determined by 1D, 2D NMR, and HR-ESI-MS data. The inhibitory effect of compounds on inflammasome activation was determined by lactate dehydrogenase (LDH) procedure. The antiproliferative activity was evaluated using MTT assay.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;The study led to the isolation of 23 compounds, including one new compound, identified as (2&lt;em&gt;Z&lt;/em&gt;)-3-[4-(&lt;em&gt;β&lt;/em&gt;-&lt;em&gt;D&lt;/em&gt;-glucopyranosyloxy)-2′-hydroxy-5′-methoxyphenyl]-2-propenoic acid (&lt;strong&gt;1&lt;/strong&gt;), together with 22 known compounds recognized as 1,4-dihydro-4-oxo-3-pyridinecarbonitrile (&lt;strong&gt;2&lt;/strong&gt;), methyl 4-methoxynicotinate (&lt;strong&gt;3&lt;/strong&gt;), 4-methoxynicotinonitrile (&lt;strong&gt;4&lt;/strong&gt;), 1-(3-&lt;em&gt;O&lt;/em&gt;-&lt;em&gt;β&lt;/em&gt;-&lt;em&gt;D&lt;/em&gt;-glucopyranosyl-4,5-dihydroxyphenyl)-ethanone (&lt;strong&gt;5&lt;/strong&gt;), neoisoastilbin (&lt;strong&gt;6&lt;/strong&gt;), isoastilbin (&lt;strong&gt;7&lt;/strong&gt;), aromadendrin &lt;strong&gt;(8&lt;/strong&gt;), neoastilbin (&lt;strong&gt;9&lt;/strong&gt;), astilbin (&lt;strong&gt;10&lt;/strong&gt;), quercitrin (&lt;strong&gt;11&lt;/strong&gt;), neoschaftoside (&lt;strong&gt;12&lt;/strong&gt;), apigenin 6,8-bis-&lt;em&gt;C&lt;/em&gt;-&lt;em&gt;α&lt;/em&gt;-&lt;em&gt;L&lt;/em&gt;-arabinoside (&lt;strong&gt;13&lt;/strong&gt;), vitexin (&lt;strong&gt;14&lt;/strong&gt;), bergenin (&lt;strong&gt;15&lt;/strong&gt;), scopoletin (&lt;strong&gt;16&lt;/strong&gt;), glucopyranoside salicyl (&lt;strong&gt;17&lt;/strong&gt;), koaburside (&lt;strong&gt;18&lt;/strong&gt;), benzyl &lt;em&gt;β&lt;/em&gt;-&lt;em&gt;D&lt;/em&gt;-glucoside (&lt;strong&gt;19&lt;/strong&gt;), icariside B5 (&lt;strong&gt;20&lt;/strong&gt;), roseoside (&lt;strong&gt;21&lt;/strong&gt;), loliolide (&lt;strong&gt;22&lt;/strong&gt;), and adenosine (&lt;strong&gt;23&lt;/strong&gt;). The tested compounds did not show LDH inhibition nor antiproliferative activity.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;Compound &lt;strong&gt;1&lt;/strong&gt; was a new glycoside. Compounds &lt;strong&gt;2&lt;/strong&gt; and &lt;strong&gt;3&lt;/strong&gt; were obtained for the first time from natural source. The 22 known compounds constituted of alkaloids (&lt;strong&gt;2&lt;/strong&gt;–&lt;strong&gt;4&lt;/strong&gt;, &lt;strong&gt;23&lt;/strong&gt;), phenolics (&lt;strong&gt;5&lt;/strong&gt;, &lt;strong&gt;15&lt;/strong&gt;, &lt;strong&gt;17&lt;/strong&gt;, &lt;strong&gt;18&lt;/strong&gt;), flavonoids (&lt;strong&gt;6&lt;/strong&gt;–&lt;strong&gt;14&lt;/strong&gt;), coumarin (&lt;strong&gt;16&lt;/strong&gt;), benzyl glycoside (&lt;strong&gt;19&lt;/strong&gt;), and norsesquiterpenes (&lt;strong&gt;20&lt;/strong&gt;–&lt;strong&gt;22&lt;/strong&gt;). All the compounds, &lt;strong&gt;1&lt;/strong&gt;–&lt;strong&gt;23&lt;/strong&gt;, were revealed from &lt;em&gt;M. hemsleyana&lt;/em&gt; for the first time. This is the initial uncovering of molecules &lt;strong&gt;1&lt;/strong&gt;–&lt;strong&gt;10&lt;/strong&gt;, &lt;strong&gt;12&lt;/strong&gt;, &lt;strong&gt;13&lt;/strong&gt;, &lt;strong&gt;17&lt;/strong&gt;–&lt;strong&gt;19&lt;/strong&gt;, and &lt;strong&gt;23&lt;/strong&gt; from the genus &lt;em&gt;Macaranga&lt;/em&gt;. The isolated compounds","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 481-486"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000746/pdfft?md5=fd934d08969499d988ae88f6a2d4dadf&pid=1-s2.0-S1674638423000746-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44776875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPLC combined with chemometrics for quality control of Huamoyan Granules or Capsules","authors":"Minhang Dou ,&nbsp;Jiayi Huang ,&nbsp;Mimi Yu ,&nbsp;Huahua Li ,&nbsp;Yang Song ,&nbsp;Ziwei Peng ,&nbsp;Shouying Du ,&nbsp;Jie Bai","doi":"10.1016/j.chmed.2023.03.005","DOIUrl":"10.1016/j.chmed.2023.03.005","url":null,"abstract":"<div><h3>Objective</h3><p>Huamaoyan Granules (HMYG) and Huamaoyan Capsules (HMYC) are Chinese patent medicines with different dosage forms of the same prescription. Due to the different preparation process, the chemical composition of these Chinese patent medicines varies greatly among different forms, but there were few studies on the difference comparison and quality control of them. In order to improve the effectiveness and safety in its clinical application, an idea combining high performance liquid chromatography (HPLC) and chemometrics was put forward to study the quality control of Chinese patent medicines in different dosage forms of the same prescription.</p></div><div><h3>Methods</h3><p>The differential markers of HMYG and HMYC were explored based on HPLC fingerprint and chemometrics including orthogonal projections to latent structures-discriminant analysis (OPLS-DA), principal component analysis (PCA), and hierarchical cluster analysis (HCA). Finally, the quantitative analysis method of related components was established by HPLC.</p></div><div><h3>Results</h3><p>A quality control method for HMYG and HMYC was established. Firstly, the chemical components of HMYG and HMYC were systematically analyzed by HPLC fingerprinting. Further exploration showed that there were 20 characteristic peaks and 57 common peaks. Then, the potential differential markers between HMYG and HMYC were explored by chemometrics, and the differential markers were screened after intersection with the 20 characteristic peaks. Finally, HPLC quantitative analysis methods for nine components were established, including seven differential markers (neochlorogenic acid, protocatechualdehyde, chlorogenic acid, cryptochlorogenic acid, caffeic acid, rosmarinic acid and salvianolic acid A). The results of HPLC quantitative analysis showed that the contents of eight components in HMYG and HMYC samples were significantly different. According to the above results, the differential markers between HMYG and HMYC screened based on HPLC fingerprint and chemometrics can effectively characterize the differences between the two dosage forms.</p></div><div><h3>Conclusion</h3><p>The present work provides a rapid and effective method for routine quality evaluation and control of HMYG and HMYC. This work also provides feasible methods for the quality evaluation and control of Chinese patent medicines with different dosage forms of the same prescription.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 449-456"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000722/pdfft?md5=cdb74b0fbddd8abb2d541fd9031160c6&pid=1-s2.0-S1674638423000722-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41446455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and characterization of chemical constituents in Mahuang Guizhi Decoction and their metabolites in rat plasma and brain by UPLC-Q-TOF/MS","authors":"Ping Wei ,&nbsp;Shiying Huang ,&nbsp;Juan Yang ,&nbsp;Mo Zhao ,&nbsp;Qiugu Chen ,&nbsp;Xiaoyu Deng ,&nbsp;Jianping Chen ,&nbsp;Yisheng Li","doi":"10.1016/j.chmed.2024.01.006","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.01.006","url":null,"abstract":"<div><h3>Objective</h3><p>Mahuang Guizhi Decoction (MGD), an essential herbal pair in traditional Chinese medicine, is able to release cold, fever and asthma, mainly containing alkaloids, flavonoids, phenylpropanoids and amino acids. However, the absorption and distribution of these four category compounds <em>in vivo</em> still remained unclearly.</p></div><div><h3>Methods</h3><p>In our research, we utilized UPLC-Q-TOF-MS technique to identify the constituents within MGD, as well as the prototypes of MGD and their metabolites absorbed in plasma and brain. We further profiled the drug-time curve of prototypes and metabolites of MGD both in plasma and brain.</p></div><div><h3>Results</h3><p>Our results showed that 105 constituents were characterized in MGD. Thirty of them could be absorbed into blood, and ten of them could be distributed into brain. We also discovered eight new bio-transformed metabolites in blood, and a half of which could pass through the blood–brain barrier. In addition, all components detected <em>in vivo</em> could be absorbed and distributed immediately.</p></div><div><h3>Conclusion</h3><p>These findings provide an approachable method to analyze the potential bio-active compounds in MGD and their <em>in vivo</em> behaviors, which could promote the efficacious material basis study of MGD and the security of clinical utilization.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 466-480"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000479/pdfft?md5=65c0244ee53b36a8b86b7af6cc5fb975&pid=1-s2.0-S1674638424000479-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biotransformation and pharmacological activities of platycosides from Platycodon grandiflorum roots","authors":"Lin Shi ,&nbsp;Tong Cui ,&nbsp;Xinyue Wang ,&nbsp;Rina Wu ,&nbsp;Junrui Wu ,&nbsp;Yanqun Wang ,&nbsp;Weiming Wang","doi":"10.1016/j.chmed.2024.01.004","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.01.004","url":null,"abstract":"<div><p>In Northeast China, Goubao pickle is a popular food fermented from the roots of <em>Platycodon grandiflorum</em> as the main material, offering a unique flavor and rich nutritional value. Platycosides in roots of <em>P. grandiflorum</em> may play a crucial role in determining the quality of Goubao pickle through microorganism fermentation. However, biotransfermation of platycosides has not been reviewed during fermentation. In this study, we reviewed platycosides in chemical diversity, metabolic processes <em>in vivo</em>, biotransformation of platycosides <em>in vitro,</em> and pharmacological effects. Finally, we also discussed how to improve the bioactive secondary platycosides we desire by regulating enzymes from microorganisms in the future.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 392-400"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000388/pdfft?md5=eb1aa15706a1576af4661e204dcd8a22&pid=1-s2.0-S1674638424000388-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative pharmacokinetics of six components in normal and rheumatoid arthritis rats after intragastrical administration of Qianghuo Shengshi Decoction granules by LC-MS/MS","authors":"Xin Li ,&nbsp;Min Wang ,&nbsp;Yuhong Zhong ,&nbsp;Qianqian Yin ,&nbsp;Zheming Hu ,&nbsp;Wenli Tian ,&nbsp;Zhongyan Liu ,&nbsp;Zhidong Liu","doi":"10.1016/j.chmed.2023.07.005","DOIUrl":"10.1016/j.chmed.2023.07.005","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the plasma pharmacokinetics of six representative components (nodakenin, osthole, 5-<em>O</em>-methylvisammioside, ferulic acid, liquiritigenin, and liquiritin), which were the ingredients of Qianghuo Shengshi Decoction (QSD) granules, in normal and rheumatoid arthritis (RA) rats administrated QSD granules intragastrically.</p></div><div><h3>Methods</h3><p>A rapid and accurate ultra-high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of six components in plasma, and it showed a good specificity, linearity, intra-day and inter-day precision, intra-day and inter-day accuracy, extraction recovery, stability, and the less matrix effect.</p></div><div><h3>Results</h3><p>The validated LC-MS/MS method was successfully used to compare the plasma pharmacokinetics of six ingredients between normal and RA rats after intragastrical administration of QSD granules and differences in the pharmacokinetics were found in two types of rats. The absorption rate in the RA rats was lower for nodakenin, osthole, 5-<em>O</em>-methylvisammioside, liquiritigenin and liquiritin than in the normal group, while the absorption rate of ferulic acid remained constant in two groups. In<!--> <!-->comparison<!--> <!-->with the normal rats, the exposure concentration of nodakenin was higher and that of other five components except for nodakenin was lower under pathological conditions. Additionally, the absorptive amount of nodakenin, osthole, 5-<em>O</em>-methylvisammioside and liquiritin was increased and that of ferulic acid and liquiritigenin was reduced in the RA rats than in the normal rats. Compared with the normal rats, the retention time of nodakenin, ferulic acid and liquiritin was reduced <em>in vivo</em>, whereas the retention time of osthole, 5-<em>O</em>-methylvisammioside and liquiritigenin was raised in the body for the RA rats. In contrast to the normal rats, the data demonstrated an increase in the elimination velocity of nodakenin and a decrease in the elimination velocity of the other five components except for nodakenin in the pathological state.</p></div><div><h3>Conclusion</h3><p>This study showed that the pharmacokinetic behavior of the six components, nodakenin, osthole, 5-<em>O</em>-methylvisammioside, ferulic acid, liquiritigenin, and liquiritin, is different <em>in vivo</em> between normal and pathological states of rats, and this research provided the necessary experimental data to explain the pharmacokinetics of QSD granules in both normal and pathological states and provide some references for its clinical application at some level.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 457-465"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000145/pdfft?md5=eaf1505a26431ba6e1e0cb6495d30c55&pid=1-s2.0-S1674638424000145-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140273177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}