Chinese Herbal Medicines最新文献

{"title":"Biotransformation and pharmacological activities of platycosides from Platycodon grandiflorum roots","authors":"Lin Shi ,&nbsp;Tong Cui ,&nbsp;Xinyue Wang ,&nbsp;Rina Wu ,&nbsp;Junrui Wu ,&nbsp;Yanqun Wang ,&nbsp;Weiming Wang","doi":"10.1016/j.chmed.2024.01.004","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.01.004","url":null,"abstract":"<div><p>In Northeast China, Goubao pickle is a popular food fermented from the roots of <em>Platycodon grandiflorum</em> as the main material, offering a unique flavor and rich nutritional value. Platycosides in roots of <em>P. grandiflorum</em> may play a crucial role in determining the quality of Goubao pickle through microorganism fermentation. However, biotransfermation of platycosides has not been reviewed during fermentation. In this study, we reviewed platycosides in chemical diversity, metabolic processes <em>in vivo</em>, biotransformation of platycosides <em>in vitro,</em> and pharmacological effects. Finally, we also discussed how to improve the bioactive secondary platycosides we desire by regulating enzymes from microorganisms in the future.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 392-400"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000388/pdfft?md5=eb1aa15706a1576af4661e204dcd8a22&pid=1-s2.0-S1674638424000388-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative pharmacokinetics of six components in normal and rheumatoid arthritis rats after intragastrical administration of Qianghuo Shengshi Decoction granules by LC-MS/MS","authors":"Xin Li ,&nbsp;Min Wang ,&nbsp;Yuhong Zhong ,&nbsp;Qianqian Yin ,&nbsp;Zheming Hu ,&nbsp;Wenli Tian ,&nbsp;Zhongyan Liu ,&nbsp;Zhidong Liu","doi":"10.1016/j.chmed.2023.07.005","DOIUrl":"10.1016/j.chmed.2023.07.005","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the plasma pharmacokinetics of six representative components (nodakenin, osthole, 5-<em>O</em>-methylvisammioside, ferulic acid, liquiritigenin, and liquiritin), which were the ingredients of Qianghuo Shengshi Decoction (QSD) granules, in normal and rheumatoid arthritis (RA) rats administrated QSD granules intragastrically.</p></div><div><h3>Methods</h3><p>A rapid and accurate ultra-high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of six components in plasma, and it showed a good specificity, linearity, intra-day and inter-day precision, intra-day and inter-day accuracy, extraction recovery, stability, and the less matrix effect.</p></div><div><h3>Results</h3><p>The validated LC-MS/MS method was successfully used to compare the plasma pharmacokinetics of six ingredients between normal and RA rats after intragastrical administration of QSD granules and differences in the pharmacokinetics were found in two types of rats. The absorption rate in the RA rats was lower for nodakenin, osthole, 5-<em>O</em>-methylvisammioside, liquiritigenin and liquiritin than in the normal group, while the absorption rate of ferulic acid remained constant in two groups. In<!--> <!-->comparison<!--> <!-->with the normal rats, the exposure concentration of nodakenin was higher and that of other five components except for nodakenin was lower under pathological conditions. Additionally, the absorptive amount of nodakenin, osthole, 5-<em>O</em>-methylvisammioside and liquiritin was increased and that of ferulic acid and liquiritigenin was reduced in the RA rats than in the normal rats. Compared with the normal rats, the retention time of nodakenin, ferulic acid and liquiritin was reduced <em>in vivo</em>, whereas the retention time of osthole, 5-<em>O</em>-methylvisammioside and liquiritigenin was raised in the body for the RA rats. In contrast to the normal rats, the data demonstrated an increase in the elimination velocity of nodakenin and a decrease in the elimination velocity of the other five components except for nodakenin in the pathological state.</p></div><div><h3>Conclusion</h3><p>This study showed that the pharmacokinetic behavior of the six components, nodakenin, osthole, 5-<em>O</em>-methylvisammioside, ferulic acid, liquiritigenin, and liquiritin, is different <em>in vivo</em> between normal and pathological states of rats, and this research provided the necessary experimental data to explain the pharmacokinetics of QSD granules in both normal and pathological states and provide some references for its clinical application at some level.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 457-465"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000145/pdfft?md5=eaf1505a26431ba6e1e0cb6495d30c55&pid=1-s2.0-S1674638424000145-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140273177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive summary of material basis − Laying a foundation for substances of medicine food homology development","authors":"Wenyuan Gao","doi":"10.1016/j.chmed.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.05.001","url":null,"abstract":"","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 311-312"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000509/pdfft?md5=2732d4acbd6b3aeaa19ee4eba0412798&pid=1-s2.0-S1674638424000509-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical constituents, pharmacological activities and quality evaluation methods of genus Hippocampus: A comprehensive review","authors":"Zhiyong Zhang ,&nbsp;Xiaoyang Zhang ,&nbsp;Xi Wang ,&nbsp;Xuting Guo ,&nbsp;Xinhao Yan ,&nbsp;Zheng Li ,&nbsp;Wenlong Li","doi":"10.1016/j.chmed.2023.04.001","DOIUrl":"10.1016/j.chmed.2023.04.001","url":null,"abstract":"<div><p>The genus <em>Hippocampus</em> is a multi-origin animal species with high medicinal and healthcare values. About 57 species of <em>Hippocampus</em> spread worldwide, of which about 14 species can be used as medicine, showing anti-oxidation, anti-inflammation, anti-depressant, anti-hypertension, anti-prostatic hyperplasia, antivirus, anti-apoptotic, antifatigue, and so on. And those pharmacological effects are mainly related to their active ingredients, including amino acids, abundant proteins (peptides and oligopeptides), fatty acids, nucleosides, steroids, and other small molecular compounds. The main means of authentication of <em>Hippocampus</em> species are morphological identification, microscopic identification, thin layer chromatography method, fingerprint method and genomics method. This review will provide useful insight for exploration, further study and precise medication of <em>Hippocampus</em> in the future.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 344-357"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000758/pdfft?md5=7d393b3e1d7cb7ad98f133b791592db0&pid=1-s2.0-S1674638423000758-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46497095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnopharmacology, chemical composition and functions of Cymbopogon citratus","authors":"Xiqin Du ,&nbsp;Meng Zhang ,&nbsp;Shuping Wang ,&nbsp;Jingyang Li ,&nbsp;Jingze Zhang ,&nbsp;Dailin Liu","doi":"10.1016/j.chmed.2023.07.002","DOIUrl":"10.1016/j.chmed.2023.07.002","url":null,"abstract":"<div><p><em>Cymbopogon citratus</em> in the gramineous family, also known as lemongrass (LG), is a perennial herb. LG, a drug and food homologous medicine, has a widely recorded medicinal value and food applications. To date, 158 LG compounds have been reported, including terpenoids, flavonoids, phenolic acids. Pharmacological and clinical studies have indicated that LG has antibacterial, neuroprotective, hypoglycemic, hypotensive, anti-inflammatory, and anti-tumor effects. This article reviews LG in ethnopharmacology, chemical composition, pharmacology, food, medicine, and daily chemical applications to provide a basis for the subsequent development of food and medicine.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 358-374"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423001028/pdfft?md5=d2d8916343465fcb851d609b65726f5f&pid=1-s2.0-S1674638423001028-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139305520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review","authors":"Jianying Liu ,&nbsp;Binzhi Zhang ,&nbsp;Leqi Wang ,&nbsp;Shasha Li ,&nbsp;Qinqiang Long ,&nbsp;Xue Xiao","doi":"10.1016/j.chmed.2023.09.007","DOIUrl":"10.1016/j.chmed.2023.09.007","url":null,"abstract":"<div><p><em>Ganoderma lucidum</em> is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. <em>G. lucidum</em> spores (GLS) are tiny germ cells released from the mushroom cap during the mature stage of growth. They contain all the genetic active substances of <em>G. lucidum</em>. <em>G. lucidum</em> spore oil (GLSO) is a lipid component extracted from broken-walled <em>Ganoderma</em> spores using supercritical CO₂ extraction technology. GLSO contains fatty acids, <em>Ganoderma</em> triterpenes, sterols and other bioactive compounds. Previous studies have demonstrated that GLSO has a wide range of pharmacological properties, including anti-tumor, anti-aging, neuroprotection, immunomodulation, hepatoprotection and modulation of metabolic diseases. This review summarizes the research progress of GLSO over the past two decades in terms of its bioactive components, extraction and processing techniques, pharmacological effects and safety evaluation. This provides a solid foundation for further research and application of GLSO.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 375-391"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000042/pdfft?md5=bffb6cf10a5e0c6d1b55b33bbfaae425&pid=1-s2.0-S1674638424000042-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139634417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnopharmacology, phytochemistry, pharmacology and product application of Platycodon grandiflorum: A review","authors":"Lanying Zhang ,&nbsp;Xinrui Wang ,&nbsp;Jingze Zhang ,&nbsp;Dailin Liu ,&nbsp;Gang Bai","doi":"10.1016/j.chmed.2024.01.005","DOIUrl":"10.1016/j.chmed.2024.01.005","url":null,"abstract":"<div><p><em>Platycodonis Radix</em> (Jiegeng in Chinese) is a well-known traditional Chinese medicine used for both medicinal and culinary purposes. Its historical use as an antitussive and expectorant has been extensively documented. Researchers, to date, have identified 219 chemical constituents in <em>Platycodon grandiflorum</em> (Jacq.) A. DC, encompassing 89 saponins, 11 flavonoids, 21 polysaccharides, 14 phenolic acids, six polyacetylenes, five sterols, 34 fatty acids, 17 amino acids, and 22 trace elements. Jiegeng exhibits diverse pharmacological effects, including antitussive and anti-phlegm properties, anti-cancer activity, anti-inflammatory effects, immune regulation, antioxidant properties, anti-obesity, and antidiabetic effects. Additionally, Jiegeng shows potential in protecting the heart and liver. Beyond its medicinal benefits, Jiegeng is highly esteemed in culinary applications, and its global demand is on the rise. Its utilization has expanded beyond medicine and food to encompass daily necessities, cosmetics, agricultural supplies, and other fields. Currently, there are 18 272 patents related to <em>P. grandiflorum.</em> This comprehensive review summarizes the latest research published over the past 20 years, providing a robust foundation for further exploration of the medicinal and health benefits of <em>P. grandiflorum</em>.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 327-343"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000406/pdfft?md5=81b1a4c46c1b7409e6f2332dc91f8e8b&pid=1-s2.0-S1674638424000406-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair","authors":"Junjie Li ,&nbsp;Ming Dong ,&nbsp;Qing Yao ,&nbsp;Xu Dong ,&nbsp;Yuanyuan Chen ,&nbsp;Jincai Wen ,&nbsp;Yingjie Xu ,&nbsp;Zhixin Wu ,&nbsp;Xiaomei Zhao ,&nbsp;Ye Xiu ,&nbsp;Xiaoyan Zhan ,&nbsp;Zhaofang Bai ,&nbsp;Xiaohe Xiao","doi":"10.1016/j.chmed.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.04.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;Acute lung injury (ALI) is characterized by inflammation and currently lacks an efficacious pharmacological intervention. The medicine combination of &lt;em&gt;Lonicerae Japonicae Flos&lt;/em&gt; (LJF) and &lt;em&gt;Forsythiae Fructus&lt;/em&gt; (FF) demonstrates combined properties in its anti-infective, anti-inflammatory, and therapeutic effects, particularly in alleviating respiratory symptoms. In previous studies, Chinese medicine has shown promising efficacy in lipopolysaccharides (LPS)-induced ALI. However, there have been no reports of LJF and FF pairing for lung injury. The aim of this study is to compare the efficacy of herb pair &lt;em&gt;Lonicerae Japonicae Flos&lt;/em&gt;-&lt;em&gt;Forsythiae Fructus&lt;/em&gt; (LF) with LJF or FF alone in the treatment of ALI, and to explore whether LJF and FF have a combined effect in the treatment of lung injury, along with the underlying mechanism involved.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;A total of 36 mice were divided into six groups (control, model, LJF, FF, LF, dexamethasone) based on the treatments they received after undergoing sham-operation/LPS tracheal instillation. H&amp;E staining and pulmonary edema indexes were used to evaluate lung injury severity. Alveolar exudate cells (AECs) were counted based on cell count in bronchoalveolar lavage fluid (BALF), and neutrophil percentage in BALF was measured using flow cytometry. Myeloperoxidase (MPO) activity in BALF was measured using enzyme-linked immunosorbent assay (ELISA), while the production of IL-1β, TNF-α, and IL-6 in the lung and secretion level of them in BALF were detected by quantitative polymerase chain reaction (qPCR) and ELISA. The effect of LJF, FF, and LF on the expression of Caspase-1 and IL-1β proteins in bone marrow derived macrophages (BMDMs) supernatant was assessed using Western blot method under various inflammasome activation conditions. In addition, the concentration of IL-1β and changes in lactatedehydrogenase (LDH) release levels in BMDMs supernatant after LJF, FF, and LF administration, respectively, were measured using ELISA. Furthermore, the effects of LJF, FF and LF on STING and IRF3 phosphorylation in BMDMs were detected by Western blot, and the mRNA changes of IFN-β, TNF-α, IL-6 and CXCL10 in BMDMs were detected by qPCR.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;LF significantly attenuated the damage to alveolar structures, pulmonary hemorrhage, and infiltration of inflammatory cells induced by LPS. This was evidenced by a decrease in lung index score and wet/dry weight ratio. Treatment with LF significantly reduced the total number of neutrophil infiltration by 75% as well as MPO activity by 88%. The efficacy of LF in reducing inflammatory factors IL-1β, TNF-α, and IL-6 in the lungs surpasses that of LJF or FF, approaching the effectiveness of dexamethasone. In BMDMs, the co-administration of 0.2 mg/mL of LJF and FF demonstrated superior inhibitory effects on the expression of nigericin-stimulated Caspase-1 and IL-1β, as well as the releas","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 422-434"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S167463842400039X/pdfft?md5=991836f0d90df0541e74f54a21582387&pid=1-s2.0-S167463842400039X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in research and utilization of botanical pesticides for agricultural pest management in Inner Mongolia, China","authors":"Chunyan Guo ,&nbsp;Lingfei Wang ,&nbsp;Namuhan Chen ,&nbsp;Mingxu Zhang ,&nbsp;Junying Jia ,&nbsp;Lijuan Lv ,&nbsp;Minhui Li","doi":"10.1016/j.chmed.2023.04.002","DOIUrl":"10.1016/j.chmed.2023.04.002","url":null,"abstract":"<div><p>Traditional Chinese herbal medicines not only cure human diseases, but also play an important role as insecticides. Compared with conventional chemical agents, traditional Chinese herbal medicines are characterized by low toxicity, low residues, and being eco-friendly, and they have become a research hotspot. Traditional Chinese herbal medicines have tremendous flexibility and indefinite potential. Therefore, this paper reviewed the types of insecticides belonging to traditional Chinese herbal medicines in Inner Mongolia, China, including their traditional uses, secondary metabolites, biological activities, action mechanisms, application methods, and development status. In addition, the most relevant issues involved in the development of traditional Chinese herbal medicines was discussed. We believe that traditional Chinese herbal medicines can be better implemented and developed; such that its other advantages, such as an insect repellent, can be promoted. Moreover, this study lays a solid foundation for further research on traditional Chinese herbal medicines in Inner Mongolia, China.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 2","pages":"Pages 248-262"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S167463842300076X/pdfft?md5=54e01ba5fc1c8fc0a0d426ce0a67c9d1&pid=1-s2.0-S167463842300076X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49275715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shouhui Tongbian Capsule in treatment of constipation: Treatment and mechanism development","authors":"Liping Gong ,&nbsp;Hang Du ,&nbsp;Xin Guo ,&nbsp;Jianchao Li ,&nbsp;Xiaomin Zhu ,&nbsp;Xianhui Shen ,&nbsp;Zhiyan Huang ,&nbsp;Kaiyi Wu ,&nbsp;Guimin Zhang ,&nbsp;Rong Sun","doi":"10.1016/j.chmed.2023.05.006","DOIUrl":"10.1016/j.chmed.2023.05.006","url":null,"abstract":"<div><p>Constipation is common in the diseases of the digestive system in clinics. With the change in diet structure and the increase in life pressure, the prevalence rate increases year by year. In traditional Chinese medicine (TCM), the location of the disease of constipation is in the large intestine, which is related to the dysfunction of lung, spleen, liver, kidney and other viscera. Its pathogenesis is conductive dysfunction of large intestine. Based on the theory, Shouhui Tongbian Capsule (SHTB) is composed of eight traditional Chinese medicines, including <em>Polygoni multiflori Radix</em> (Heshouwu in Chinese), <em>Aloe</em> (Luhui in Chinese), <em>Cassiae Semen</em> (Juemingzi in Chinese), <em>Ginseng Radix</em> et <em>Rhizoma</em> (Renshen in Chinese), <em>Lycii Fructus</em> (Gouqizi in Chinese), <em>Asini Corii Colla</em> (Ejiao in Chinese), <em>Aurantii Fructus Immaturus</em> (Zhishi in Chinese), and <em>Atractylodis Macrocephalae Rhizoma</em> (Baizhu in Chinese), which could help to release excessive turbid, and nourishing <em>yin</em> and supplementing <em>qi</em> in the treatment. This study has been carried out to review the latest advances of SHTB in the treatment of constipation. The results showed that significant effect of SHTB was found in the treatment of constipation, such as functional constipation, and constipation associated with tumor chemotherapy, colitis, type 2 diabetes and chronic cardiac failure. Besides, obvious adverse reactions were not observed. SHTB could effectively treat five types of constipation, provide direction for the future exploration of SHTB in the treatment of other types of constipation.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 2","pages":"Pages 239-247"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423001016/pdfft?md5=c9267d87e671fb0e3527725e7a8dd717&pid=1-s2.0-S1674638423001016-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139297098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}