Chinese Herbal Medicines最新文献

{"title":"Germplasm resources and secondary metabolism regulation in Reishi mushroom (Ganoderma lucidum)","authors":"Xinyu He ,&nbsp;Yiwen Chen ,&nbsp;Zhenhao Li ,&nbsp;Ling Fang ,&nbsp;Haimin Chen ,&nbsp;Zongsuo Liang ,&nbsp;Ann Abozeid ,&nbsp;Zongqi Yang ,&nbsp;Dongfeng Yang","doi":"10.1016/j.chmed.2023.01.005","DOIUrl":"https://doi.org/10.1016/j.chmed.2023.01.005","url":null,"abstract":"<div><p><em>Ganoderma lucidum</em> is a valuable medical macrofungus with a myriad of diverse secondary metabolites, in which triterpenoids are the major constituents. This paper introduced the germplasm resources of genus <em>Ganoderma</em> from textual research, its distribution and identification at the molecular level. Also we overviewed <em>G. lucidum</em> in the components, the biological activities and biosynthetic pathways of ganoderic acid, aiming to provide scientific evidence for the development and utilization of <em>G. lucidum</em> germplasm resources and the biosynthesis of ganoderic acid.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 376-382"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49803943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical constituents from leaves of Jatropha curcas","authors":"Yingjie Wang ,&nbsp;Di Zhou ,&nbsp;Xiaolin Bai ,&nbsp;Qingqi Meng ,&nbsp;Haihui Xie ,&nbsp;Guojiang Wu ,&nbsp;Gang Chen ,&nbsp;Yue Hou ,&nbsp;Ning Li","doi":"10.1016/j.chmed.2022.08.010","DOIUrl":"https://doi.org/10.1016/j.chmed.2022.08.010","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the chemical constituents from the leaves of <em>Jatropha curcas</em> and evaluate their inhibition on lipopolysaccharide (LPS)-activated BV-2 microglia cells.</p></div><div><h3>Methods</h3><p>The <em>n</em>-BuOH extract of the leaves of <em>J. curcas</em> was isolated by macroporous adsorption resin, silica gel, ODS, column chromatography and semi-preparative HPLC. The structures of the compounds were identified by MS, NMR, ECD, and other spectroscopic methods. In addition, anti-neuroinflammatory effects of isolated compounds were evaluated by measuring the production of nitric oxide (NO) in over-activated BV-2 cells.</p></div><div><h3>Results</h3><p>Seventeen compounds, including (7<em>R</em>,8<em>S</em>)-crataegifin A-4-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranoside (<strong>1</strong>), (8<em>R</em>,8′<em>R</em>)-arctigenin (<strong>2</strong>), arctigenin-4′-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranoside (<strong>3</strong>), (-)-syringaresinol (<strong>4</strong>), syringaresinol-4′-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranoside (<strong>5</strong>), (-)-pinoresinol (<strong>6</strong>), pinoresinol-4′-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranoside (<strong>7</strong>), buddlenol D (<strong>8</strong>), (2<em>R</em>,3<em>R</em>)-dihydroquercetin (<strong>9</strong>), (2<em>S</em>,3<em>S</em>)-epicatechin (<strong>10</strong>), (2<em>R</em>,3<em>S</em>)-catechin (<strong>11</strong>), isovitexin (<strong>12</strong>), naringenin-7-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranoside (<strong>13</strong>), chamaejasmin (<strong>14</strong>), neochamaejasmin B (<strong>15</strong>), isoneochamaejasmin A (<strong>16</strong>), and tomentin-5-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranoside (<strong>17</strong>) were isolated and identified. Compounds <strong>2</strong>, <strong>4</strong> and <strong>8</strong> significantly inhibited the release of NO in BV-2 microglia activated by LPS, with IC₅₀ values of 18.34, 29.33 and 26.30 μmol/L, respectively.</p></div><div><h3>Conclusion</h3><p>Compound <strong>1</strong> is a novel compound, and compounds <strong>2</strong>, <strong>3</strong>, <strong>8</strong>, <strong>14</strong>–<strong>17</strong> are isolated from <em>Jatropha</em> genus for the first time. In addition, the lignans significantly inhibited NO release and the inhibitory activity was decreased after glycosylation.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 463-469"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49803941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative chemical characters of Pseudostellaria heterophylla from geographical origins of China","authors":"Miao Sha,&nbsp;Xiaohuan Li,&nbsp;Yu Liu,&nbsp;Hongyue Tian,&nbsp;Xu Liang,&nbsp;Xia Li,&nbsp;Wenyuan Gao","doi":"10.1016/j.chmed.2022.10.005","DOIUrl":"https://doi.org/10.1016/j.chmed.2022.10.005","url":null,"abstract":"<div><h3>Objective</h3><p><em>Pseudostellaria heterophylla</em> has been paid more attention in recent years, mainly as a medicine food homology plant. The content determination of <em>P. heterophylla</em> is not specified in the <em>Chinese Pharmacopoeia</em> (version 2020). The environmental conditions in different production areas could exert an influence on the quality of <em>P. heterophylla</em>. The purpose of this study is to discriminate <em>P. heterophylla</em> collected from different geographical origins of China.</p></div><div><h3>Methods</h3><p>In this study, the content of polysaccharide in 28 batches of <em>P. heterophylla</em> was determined using phenol–sulfuric acid. HPLC fingerprints were established under optimised HPLC-PDA methods. Subsequently, the similarity analysis (SA) and the quantification of heterophyllin B were analyzed. The metabolites of <em>P. heterophylla</em> were identified and evaluated using UHPLC-Q Exactive HF orbitrap MS system. Principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), hierarchical cluster analysis (HCA) and orthogonal PLS-DA (OPLS-DA) were performed based on all peak areas.</p></div><div><h3>Results</h3><p>The polysaccharide content in Guizhou and Jiangsu was higher than that of other production areas, which varied significant from different origins. While the content of heterophyllin B in Anhui and Jiangsu was high. The correlation coefficients of HPLC fingerprints for 28 batches samples ranged from 0.877 to 0.990, and the characteristic map can be used to identify and evaluate the quality of <em>P. heterophylla</em>. The samples from Fujian, Guizhou, Jiangsu provinces can be relatively separated using multivariate statistical analysis including PCA, PLS-DA, HCA, OPLS-DA, indicating that their metabolic compositions were significantly different. Ultimately, a total of 15 metabolites which were filtrated by a VIP-value &gt; 1 and a <em>P</em>-value &lt; 0.05 associated with the separation of different origins were identified.</p></div><div><h3>Conclusion</h3><p>HPLC fingerprint was established to evaluate the quality and authenticity of <em>P. heterophylla</em>. The present work showed that the difference of geographic distributions had an influence on the internal chemical compositions. A sensitive and rapid untargeted metabolomics approach by UHPLC-Q Exactive HF orbitrap MS was utilized to evaluate <em>P. heterophylla</em> from different origins in China for the first time. Overall, this study provides insights to metabolomics of <em>P. heterophylla</em> and supplies important reference values for the development of functional foods.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 439-446"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49838741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Essential role of medicine and food homology in health and wellness","authors":"Junshi Chen","doi":"10.1016/j.chmed.2023.05.001","DOIUrl":"10.1016/j.chmed.2023.05.001","url":null,"abstract":"","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 347-348"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9941924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical constituents from leaves of Jatropha curcas","authors":"Yingjie Wang ,&nbsp;Di Zhou ,&nbsp;Xiaolin Bai ,&nbsp;Qingqi Meng ,&nbsp;Haihui Xie ,&nbsp;Guojiang Wu ,&nbsp;Gang Chen ,&nbsp;Yue Hou ,&nbsp;Ning Li","doi":"10.1016/j.chmed.2022.08.010","DOIUrl":"https://doi.org/10.1016/j.chmed.2022.08.010","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the chemical constituents from the leaves of <em>Jatropha curcas</em> and evaluate their inhibition on lipopolysaccharide (LPS)-activated BV-2 microglia cells.</p></div><div><h3>Methods</h3><p>The <em>n</em>-BuOH extract of the leaves of <em>J. curcas</em> was isolated by macroporous adsorption resin, silica gel, ODS, column chromatography and semi-preparative HPLC. The structures of the compounds were identified by MS, NMR, ECD, and other spectroscopic methods. In addition, anti-neuroinflammatory effects of isolated compounds were evaluated by measuring the production of nitric oxide (NO) in over-activated BV-2 cells.</p></div><div><h3>Results</h3><p>Seventeen compounds, including (7<em>R</em>,8<em>S</em>)-crataegifin A-4-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranoside (<strong>1</strong>), (8<em>R</em>,8′<em>R</em>)-arctigenin (<strong>2</strong>), arctigenin-4′-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranoside (<strong>3</strong>), (-)-syringaresinol (<strong>4</strong>), syringaresinol-4′-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranoside (<strong>5</strong>), (-)-pinoresinol (<strong>6</strong>), pinoresinol-4′-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranoside (<strong>7</strong>), buddlenol D (<strong>8</strong>), (2<em>R</em>,3<em>R</em>)-dihydroquercetin (<strong>9</strong>), (2<em>S</em>,3<em>S</em>)-epicatechin (<strong>10</strong>), (2<em>R</em>,3<em>S</em>)-catechin (<strong>11</strong>), isovitexin (<strong>12</strong>), naringenin-7-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranoside (<strong>13</strong>), chamaejasmin (<strong>14</strong>), neochamaejasmin B (<strong>15</strong>), isoneochamaejasmin A (<strong>16</strong>), and tomentin-5-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranoside (<strong>17</strong>) were isolated and identified. Compounds <strong>2</strong>, <strong>4</strong> and <strong>8</strong> significantly inhibited the release of NO in BV-2 microglia activated by LPS, with IC₅₀ values of 18.34, 29.33 and 26.30 μmol/L, respectively.</p></div><div><h3>Conclusion</h3><p>Compound <strong>1</strong> is a novel compound, and compounds <strong>2</strong>, <strong>3</strong>, <strong>8</strong>, <strong>14</strong>–<strong>17</strong> are isolated from <em>Jatropha</em> genus for the first time. In addition, the lignans significantly inhibited NO release and the inhibitory activity was decreased after glycosylation.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 463-469"},"PeriodicalIF":3.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49703161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucuronic acid metabolites of phenolic acids target AKT-PH domain to improve glucose metabolism","authors":"Jie Gao ,&nbsp;Manqian Zhang ,&nbsp;Xingwang Zu ,&nbsp;Xue Gu ,&nbsp;Erwei Hao ,&nbsp;Xiaotao Hou ,&nbsp;Gang Bai","doi":"10.1016/j.chmed.2022.11.005","DOIUrl":"10.1016/j.chmed.2022.11.005","url":null,"abstract":"<div><h3>Objective</h3><p>Phenolic acids widely exist in the human diet and exert beneficial effects such as improving glucose metabolism. It is not clear whether phenolic acids or their metabolites play a major role <em>in vivo</em>. In this study, caffeic acid (CA) and ferulic acid (FA), the two most ingested phenolic acids, and their glucuronic acid metabolites, caffeic-4′-<em>O</em>-glucuronide (CA4G) and ferulic-4′-<em>O</em>-glucuronide (FA4G), were investigated.</p></div><div><h3>Methods</h3><p>Three insulin resistance models <em>in vitro</em> were established by using TNF-α, insulin and palmitic acid (PA) in HepG2 cells, respectively. We compared the effects of FA, FA4G, CA and CA4G on glucose metabolism in these models by measuring the glucose consumption levels. The potential targets and related pathways were predicted by network pharmacology. Fluorescence quenching measurement was used to analyze the binding between the compounds and the predicted target. To investigate the binding mode, molecular docking was performed. Then, we performed membrane recruitment assays of the AKT pleckstrin homology (PH) domain with the help of the PH-GFP plasmid. AKT enzymatic activity was determined to compare the effects between the metabolites with their parent compounds. Finally, the downstream signaling pathway of AKT was investigated by Western blot analysis.</p></div><div><h3>Results</h3><p>The results showed that CA4G and FA4G were more potent than their parent compounds in increasing glucose consumption. AKT was predicted to be the key target of CA4G and FA4G by network pharmacology analysis. The fluorescence quenching test confirmed the more potent binding to AKT of the two metabolites compared to their parent compounds. The molecular docking results indicated that the carbonyl group in the glucuronic acid structure of CA4G and FA4G might bind to the PH domain of AKT at the key Arg-25 site. CA4G and FA4G inhibited the translocation of the AKT PH domain to the membrane, while increasing the activity of AKT. Western blot analysis demonstrated that the metabolites could increase the phosphorylation of AKT and downstream glycogen synthase kinase 3β in the AKT signaling pathway to increase glucose consumption.</p></div><div><h3>Conclusion</h3><p>In conclusion, our results suggested that the metabolites of phenolic acids, which contain glucuronic acid, are the key active substances and that they activate AKT by targeting the PH domain, thus improving glucose metabolism.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 398-406"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/79/a6/main.PMC10394347.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10305882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of Longxue Tongluo Capsule on ischemic stroke rats revealed by LC-MS/MS-based metabolomics approach","authors":"Jing Sun ,&nbsp;Xianyang Chen ,&nbsp;Yongru Wang ,&nbsp;Yuelin Song ,&nbsp;Bo Pan ,&nbsp;Bei Fan ,&nbsp;Fengzhong Wang ,&nbsp;Xiaonan Chen ,&nbsp;Pengfei Tu ,&nbsp;Jiarui Han ,&nbsp;Huixia Huo ,&nbsp;Jun Li","doi":"10.1016/j.chmed.2022.12.010","DOIUrl":"10.1016/j.chmed.2022.12.010","url":null,"abstract":"<div><h3>Objective</h3><p>The present study aimed to evaluate the therapeutic effect and explore the underlying mechanisms of Longxue Tongluo Capsule (LTC) on ischemic stroke rats.</p></div><div><h3>Methods</h3><p>Twenty-six rats were randomly divided into four groups, including sham group, sham + LTC group, MCAO group, and MCAO + LTC group. Ischemic stroke rats were simulated by middle cerebral artery occlusion (MCAO), and LTC treatment group were orally administrated with 300 mg/kg of LTC once daily for seven consecutive days. LTC therapy was validated in terms of neurobehavioral abnormality evaluation, cerebral infarct area, and histological assessments. The plasma metabolome comparisons amongst different groups were conducted by UHPLC-Q Exactive MS in combination with subsequent multivariate statistical analysis, aiming to finding the molecules in respond to the surgery or LTC treatment.</p></div><div><h3>Results</h3><p>Intragastric administration of LTC significantly decreased not only the neurobehavioral abnormality scores but also the cerebral infarct area of MCAO rats. The interstitial edema, atrophy, and pyknosis of glial and neuronal cells occurred in the infarcted area, core area, and marginal area of cerebral cortex were improved after LTC treatment. A total of 13 potential biomarkers were observed, and Youden index of 11 biomarkers such as LysoPC, SM, and PE were more than 0.7, which were involved in neuroprotective process. The correlation and pathway analysis showed that LTC was beneficial to ischemic stroke rats via regulating glycerophospholipid and sphingolipid metabolism, together with nicotinate and nicotinamide metabolism. Heatmap and ternary analysis indicated the synergistic effect of carbohydrates and lipids may be induced by flavonoid intake from LTC.</p></div><div><h3>Conclusion</h3><p>The present study could provide evidence that metabolomics, as systematic approach, revealed its capacity to evaluate the holistic efficacy of TCM, and investigate the molecular mechanism underlying the clinical treatment of LTC on ischemic stroke.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 430-438"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9935826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phyllanthi Fructus: A modal medicinal and food homologous item in quality evaluation","authors":"Gefei Li ,&nbsp;Yurou Jiang ,&nbsp;Dingkun Zhang ,&nbsp;Li Han ,&nbsp;Taigang Mo ,&nbsp;Sanhu Fan ,&nbsp;Haozhou Huang ,&nbsp;Junzhi Lin","doi":"10.1016/j.chmed.2022.10.006","DOIUrl":"https://doi.org/10.1016/j.chmed.2022.10.006","url":null,"abstract":"<div><p><em>Phyllanthi Fructus</em> is a highly unique medicine and food homologous item, which exhibits distinctive flavor, notable nutritional value, and abundant pharmacological activity. It has enormous potential in the creation of health products and pharmaceuticals. However, due to the unique laws of quality formation and transfer of <em>Phyllanthi Fructus</em>, its appearance, shape, chemical compositions, nutrients, and sensory flavors are frequently greatly influenced by botanical resources, the processing and storage conditions.<!--> <!-->As a result, the current quality evaluation model is difficult to meet the needs of <em>Phyllanthi Fructus</em> as a medicine and food homologous item in the development of diversified products. This paper constructs the hierarchical utilization mode of <em>Phyllanthi Fructus</em> based on its unique quality formation and transmission laws, explores the quality evaluation model for food-oriented use and medicinal-oriented use, respectively, and systematically describes the quality evaluation idea under diversified application scenarios. This paper aims to serve as a reference for the construction of a quality evaluation model suitable for the medicine and food homologous item of <em>Phyllanthi Fructus</em>.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 360-368"},"PeriodicalIF":3.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49729060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perilla frutescens: A traditional medicine and food homologous plant","authors":"Xinling Wu ,&nbsp;Shuting Dong ,&nbsp;Hongyu Chen ,&nbsp;Miaoxian Guo ,&nbsp;Zhiying Sun ,&nbsp;Hongmei Luo","doi":"10.1016/j.chmed.2023.03.002","DOIUrl":"https://doi.org/10.1016/j.chmed.2023.03.002","url":null,"abstract":"<div><p><em>Perilla frutescens</em>, an annual herb of the Labiatae family, has been cultivated in China for more than 2000 years. <em>P. frutescens</em> is the one of the first medicinal and edible plant published by the Ministry of Health. Its leaves, stems and seeds can be used as medicine and edible food. Because of the abundant nutrients and bioactive components in this plant, <em>P. frutescens</em> has been studied extensively in medicine, food, health care and chemical fields with great prospects for development. This paper reviews the cultivation history, chemical compositions and pharmacological activities of <em>P. frutescens</em>, which provides a reference for the development and utilization of <em>P. frutescens</em> resources.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 369-375"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49884357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seven new 3,4-dihydro-furanocoumarin derivatives from Angelica dahurica","authors":"Yang Wang ,&nbsp;Fanyu Shi ,&nbsp;Zihan Lu ,&nbsp;Mingliang Zhang ,&nbsp;Zekun Zhang ,&nbsp;Fangfang Jia ,&nbsp;Beibei Zhang ,&nbsp;Lishan Ouyang ,&nbsp;Zhixiang Zhu ,&nbsp;Shepo Shi","doi":"10.1016/j.chmed.2023.02.001","DOIUrl":"https://doi.org/10.1016/j.chmed.2023.02.001","url":null,"abstract":"<div><h3>Objective</h3><p>To study the chemical constituents of the roots of <em>Angelica dahurica</em>, a well-known Chinese herbal medicine named Baizhi in Chinese.</p></div><div><h3>Methods</h3><p>Compounds were separated by various chromatographies, and the structures of new compounds were elucidated based on the analysis of their spectroscopic and spectrometric data (1D, 2D NMR, HRESI MS, IR, and UV). The absolute configurations of new compounds were determined by the calculated electronic circular dichroism and chemical derivatization. The inhibitory activities of all isolates against nitric oxide (NO) production were evaluated using lipopolysaccharide-activated RAW 264.7 macrophage cells.</p></div><div><h3>Results</h3><p>Seven new 3,4-dihydro-furanocoumarin derivatives (<strong>1a</strong>/<strong>1b</strong>, <strong>2a</strong>/<strong>2b</strong>, <strong>3a</strong>/<strong>3b</strong>, <strong>4</strong>) together with a known furanocoumarin (<strong>5</strong>) were isolated from the roots of <em>A. dahurica</em>. The new compounds included three pairs of enantiomers, (4<em>S</em>, 2′′<em>R</em>)-angelicadin A (<strong>1a</strong>)/(4<em>R</em>, 2′′<em>S</em>)-angelicadin A (<strong>1b</strong>), (4<em>S</em>, 2′′<em>S</em>)-angelicadin A (<strong>2a</strong>)/(4<em>R</em>, 2′′<em>R</em>)-angelicadin A (<strong>2b</strong>), and (4<em>S</em>, 2′′<em>S</em>)-secoangelicadin A (<strong>3a</strong>)/(4<em>R</em>, 2′′<em>R</em>)-secoangelicadin A (<strong>3b</strong>), together with (4<em>R</em>, 2′′<em>R</em>)-secoangelicadin A methyl ester (<strong>4</strong>). The known xanthotoxol (<strong>5)</strong> inhibited the NO production with the half-maximal inhibitory concentration (IC₅₀) value of (32.8 ± 0.8) µmol/L, but all the new compounds showed no inhibitory activities at the concentration of 100 µmol/L.</p></div><div><h3>Conclusion</h3><p>This is the first report of the discovery of 3,4-dihydro-furanocoumarins from <em>A. dahurica</em>. The results are not only meaningful for the understanding of the chemical constituents of <em>A. dahurica</em>, but also enrich the reservoir of natural products.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 3","pages":"Pages 457-462"},"PeriodicalIF":3.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49702939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}