Chuan Tang, Rui Gao, Xiaoyuan Tang, Yu Zhang, Weixing Feng, Baomin Feng, Xuan Lu
{"title":"东北红豆杉内生真菌青霉HDS-Z-1E的代谢产物及其对过氧化氢酶的激活作用","authors":"Chuan Tang, Rui Gao, Xiaoyuan Tang, Yu Zhang, Weixing Feng, Baomin Feng, Xuan Lu","doi":"10.1016/j.chmed.2022.12.009","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To study the compounds isolated from <em>Penicillium</em> HDS-Z-1E, an endophytic fungal strain isolated from <em>Taxus cuspidata</em> and their activation effect of catalase (CAT).</p></div><div><h3>Methods</h3><p>The chemical constituents were isolated from <em>Penicillium</em> HDS-Z-1E, by using silica gel, Sephadex LH-20 and HPLC. The structural elucidations of five metabolites were elucidated on the basis of spectroscopic including <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, HMBC and HSQC. Their activation sites of catalase have been investigated by molecular docking.</p></div><div><h3>Results</h3><p>Five metabolites, compounds (<strong>1</strong>–<strong>5</strong>) were isolated from <em>Penicillium</em> HDS-Z-1E and identified as 4-hydroxy-4-methyltetrahydro-2<em>H</em>-pyran-2-one (<strong>1</strong>), 4-hydroxymethyl-5, 6-dihydro-pyran-2-one (<strong>2</strong>), 5, 6-dihydro-2-oxo-2<em>H</em>-pyran-4-carboxylic (<strong>3</strong>), <em>N</em>-acetyl-hydrazinobenzoic acid (<strong>4</strong>), and methyl 2-(2, 5-dihydroxyphenyl) acetate (<strong>5</strong>).</p></div><div><h3>Conclusion</h3><p>Compound <strong>3</strong> is a new compound. Compounds <strong>3</strong> and <strong>4</strong> may have potential activators of catalase, providing a theoretical basis for the development of CAT activators.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 2","pages":"Pages 227-230"},"PeriodicalIF":4.7000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000515/pdfft?md5=33e6a3b81bc02850668e73681a37affc&pid=1-s2.0-S1674638423000515-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Metabolites isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase\",\"authors\":\"Chuan Tang, Rui Gao, Xiaoyuan Tang, Yu Zhang, Weixing Feng, Baomin Feng, Xuan Lu\",\"doi\":\"10.1016/j.chmed.2022.12.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To study the compounds isolated from <em>Penicillium</em> HDS-Z-1E, an endophytic fungal strain isolated from <em>Taxus cuspidata</em> and their activation effect of catalase (CAT).</p></div><div><h3>Methods</h3><p>The chemical constituents were isolated from <em>Penicillium</em> HDS-Z-1E, by using silica gel, Sephadex LH-20 and HPLC. The structural elucidations of five metabolites were elucidated on the basis of spectroscopic including <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, HMBC and HSQC. Their activation sites of catalase have been investigated by molecular docking.</p></div><div><h3>Results</h3><p>Five metabolites, compounds (<strong>1</strong>–<strong>5</strong>) were isolated from <em>Penicillium</em> HDS-Z-1E and identified as 4-hydroxy-4-methyltetrahydro-2<em>H</em>-pyran-2-one (<strong>1</strong>), 4-hydroxymethyl-5, 6-dihydro-pyran-2-one (<strong>2</strong>), 5, 6-dihydro-2-oxo-2<em>H</em>-pyran-4-carboxylic (<strong>3</strong>), <em>N</em>-acetyl-hydrazinobenzoic acid (<strong>4</strong>), and methyl 2-(2, 5-dihydroxyphenyl) acetate (<strong>5</strong>).</p></div><div><h3>Conclusion</h3><p>Compound <strong>3</strong> is a new compound. Compounds <strong>3</strong> and <strong>4</strong> may have potential activators of catalase, providing a theoretical basis for the development of CAT activators.</p></div>\",\"PeriodicalId\":9916,\"journal\":{\"name\":\"Chinese Herbal Medicines\",\"volume\":\"16 2\",\"pages\":\"Pages 227-230\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1674638423000515/pdfft?md5=33e6a3b81bc02850668e73681a37affc&pid=1-s2.0-S1674638423000515-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Herbal Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1674638423000515\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Herbal Medicines","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1674638423000515","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Metabolites isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase
Objective
To study the compounds isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase (CAT).
Methods
The chemical constituents were isolated from Penicillium HDS-Z-1E, by using silica gel, Sephadex LH-20 and HPLC. The structural elucidations of five metabolites were elucidated on the basis of spectroscopic including 1H-NMR, 13C-NMR, HMBC and HSQC. Their activation sites of catalase have been investigated by molecular docking.
Results
Five metabolites, compounds (1–5) were isolated from Penicillium HDS-Z-1E and identified as 4-hydroxy-4-methyltetrahydro-2H-pyran-2-one (1), 4-hydroxymethyl-5, 6-dihydro-pyran-2-one (2), 5, 6-dihydro-2-oxo-2H-pyran-4-carboxylic (3), N-acetyl-hydrazinobenzoic acid (4), and methyl 2-(2, 5-dihydroxyphenyl) acetate (5).
Conclusion
Compound 3 is a new compound. Compounds 3 and 4 may have potential activators of catalase, providing a theoretical basis for the development of CAT activators.
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