Metabolites isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase

IF 4.7 4区医学 Q1 CHEMISTRY, MEDICINAL

Chinese Herbal Medicines Pub Date : 2024-04-01 DOI:10.1016/j.chmed.2022.12.009

Chuan Tang, Rui Gao, Xiaoyuan Tang, Yu Zhang, Weixing Feng, Baomin Feng, Xuan Lu

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引用次数: 0

Abstract

Objective

To study the compounds isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase (CAT).

Methods

The chemical constituents were isolated from Penicillium HDS-Z-1E, by using silica gel, Sephadex LH-20 and HPLC. The structural elucidations of five metabolites were elucidated on the basis of spectroscopic including ¹H-NMR, ¹³C-NMR, HMBC and HSQC. Their activation sites of catalase have been investigated by molecular docking.

Results

Five metabolites, compounds (1–5) were isolated from Penicillium HDS-Z-1E and identified as 4-hydroxy-4-methyltetrahydro-2H-pyran-2-one (1), 4-hydroxymethyl-5, 6-dihydro-pyran-2-one (2), 5, 6-dihydro-2-oxo-2H-pyran-4-carboxylic (3), N-acetyl-hydrazinobenzoic acid (4), and methyl 2-(2, 5-dihydroxyphenyl) acetate (5).

Conclusion

Compound 3 is a new compound. Compounds 3 and 4 may have potential activators of catalase, providing a theoretical basis for the development of CAT activators.

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东北红豆杉内生真菌青霉HDS-Z-1E的代谢产物及其对过氧化氢酶的激活作用

方法利用硅胶、Sephadex LH-20 和 HPLC 从青霉 HDS-Z-1E 中分离出化学成分。通过 1H-NMR、13C-NMR、HMBC 和 HSQC 等光谱分析，阐明了五种代谢物的结构。通过分子对接研究了它们对过氧化氢酶的激活位点。结果从青霉 HDS-Z-1E 中分离出五种代谢物化合物（1-5），并鉴定为 4-羟基-4-甲基四氢-2H-吡喃-2-酮（1）、4-羟甲基-5、6-二氢吡喃-2-酮 (2)、5, 6-二氢-2-氧代-2H-吡喃-4-羧酸 (3)、N-乙酰基肼基苯甲酸 (4) 和 2-(2,5-二羟基苯基) 乙酸甲酯 (5)。结论化合物 3 是一种新化合物。化合物 3 和 4 可能是过氧化氢酶的潜在激活剂，为开发 CAT 激活剂提供了理论依据。

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来源期刊

Chinese Herbal Medicines CHEMISTRY, MEDICINAL-

CiteScore

4.40

自引率

5.30%

发文量

629

审稿时长

10 weeks

期刊介绍： Chinese Herbal Medicines is intended to disseminate the latest developments and research progress in traditional and herbal medical sciences to researchers, practitioners, academics and administrators worldwide in the field of traditional and herbal medicines. The journal's international coverage ensures that research and progress from all regions of the world are widely included. CHM is a core journal of Chinese science and technology. The journal entered into the ESCI database in 2017, and then was included in PMC, Scopus and other important international search systems. In 2019, CHM was successfully selected for the “China Science and Technology Journal Excellence Action Plan” project, which has markedly improved its international influence and industry popularity. CHM obtained the first impact factor of 3.8 in Journal Citation Reports (JCR) in 2023.