Chemistry & Biodiversity最新文献_第3页

Rosemary Essential Oil Microemulsion for Fungal Keratitis Treatment. 迷迭香精油微乳治疗真菌性角膜炎。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-15 DOI: 10.1002/cbdv.202502124

Saulo Ribeiro, Mariana Coelho Moraes, Denise de Oliveira Scoaris, Jovita Eugênia Gazinelli Cruz Madeira, Silvia Ligório Fialho, Carolina Paula de Souza Moreira

{"title":"Rosemary Essential Oil Microemulsion for Fungal Keratitis Treatment.","authors":"Saulo Ribeiro, Mariana Coelho Moraes, Denise de Oliveira Scoaris, Jovita Eugênia Gazinelli Cruz Madeira, Silvia Ligório Fialho, Carolina Paula de Souza Moreira","doi":"10.1002/cbdv.202502124","DOIUrl":"https://doi.org/10.1002/cbdv.202502124","url":null,"abstract":"This study investigated the use of Rosmarinus officinalis (rosemary) essential oil in a microemulsion (ME) formulation for the treatment of ocular fungal keratitis, a serious infection that can lead to blindness. The ME was characterized in terms of pH, stability, homogeneity, osmolarity, and other physicochemical properties. The Hen's Egg Test-Chorioallantoic Membrane assay was used to assess ocular irritancy, and antifungal efficacy was evaluated using the minimum inhibitory concentration method. The oil extraction yielded 1.2%, with eucalyptol (37.89%) as the major compound. The formulation showed a suitable pH (6.96), particle size of 11.35 nm, good stability, and was classified as non-irritant with an irritation score = 1.5. It exhibited strong antifungal activity against Candida parapsilosis (96.1%), C. krusei (100%), C. albicans (99.1%), Fusarium graminearum (90.5%), and Aspergillus parasiticus (79.5%). The results highlight the potential of rosemary essential oil as a base for developing eye drops for the treatment of fungal keratitis.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02124"},"PeriodicalIF":2.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biotechnological Potential of Seaweeds from Bahia, Brazil: Metabolomic insights, Photoprotection and Antioxidant Activity. 巴西巴伊亚海藻的生物技术潜力：代谢组学见解、光保护和抗氧化活性。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-15 DOI: 10.1002/cbdv.202502708

Keila Almeida Santana, Isadora de Jesus da Silva, Victor Pena Ribeiro, José Marcos de Castro Nunes, Hosana Maria Debonsi, Ian Castro-Gamboa, Lorena Rigo Gaspar, Gustavo Souza Dos Santos, Aníbal de Freitas Santos Júnior

{"title":"Biotechnological Potential of Seaweeds from Bahia, Brazil: Metabolomic insights, Photoprotection and Antioxidant Activity.","authors":"Keila Almeida Santana, Isadora de Jesus da Silva, Victor Pena Ribeiro, José Marcos de Castro Nunes, Hosana Maria Debonsi, Ian Castro-Gamboa, Lorena Rigo Gaspar, Gustavo Souza Dos Santos, Aníbal de Freitas Santos Júnior","doi":"10.1002/cbdv.202502708","DOIUrl":"https://doi.org/10.1002/cbdv.202502708","url":null,"abstract":"Seaweeds have wide biotechnological applications. This study evaluated the chemical profile, photoprotective, and antioxidant potential of Padina sp., Caulerpa sertularioides, and Solieria filiformis collected in Bahia, Brazil. Chemical characterization by gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) confirmed fucosterol in Padina sp., β-sitosterol in C. sertularioides, and cholesterol in S. filiformis alongside fatty acids and aromatic metabolites; multivariate analyses supported species-specific chemical patterns. The extracts exhibited ultraviolet (UV) absorption, in specific the UVA range, and were nonirritant in the Organization for Economic Co-operation and Development (OECD) Test Guideline (TG) 491 assay. In human keratinocytes (HaCaT), C. sertularioides reduced UV-induced reactive oxygen species (ROS) by 75%, whereas Padina sp. and S. filiformis achieved 42% reduction. Conversely, extracts exhibited photodegradation in the UV region and phototoxic potential in the OECD TG 432 (3T3 neutral red uptake, NRU) assay. Because these trials used complex crude extracts, future studies should optimize the extraction process, fractionate bioactive-rich fractions, and isolate key compounds. These results highlight Brazilian algae as promising sources of new compounds and serve as a starting point for further investigations.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02708"},"PeriodicalIF":2.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlights on the Mechanism of Eucalyptus camaldulensis Dehnh. Psyllid Infestation: Insight From Its Relationship With the Chemical Composition of Essential Oil Through Computational Study. 山茶桉（Eucalyptus camaldulensis Dehnh）作用机理研究进展木虱侵扰：通过计算研究从其与精油化学成分的关系中获得启示。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-15 DOI: 10.1002/cbdv.202500435

Safia Abla, Wafa Tachoua, Ouahid Zanndouche

{"title":"Highlights on the Mechanism of Eucalyptus camaldulensis Dehnh. Psyllid Infestation: Insight From Its Relationship With the Chemical Composition of Essential Oil Through Computational Study.","authors":"Safia Abla, Wafa Tachoua, Ouahid Zanndouche","doi":"10.1002/cbdv.202500435","DOIUrl":"https://doi.org/10.1002/cbdv.202500435","url":null,"abstract":"Glycaspis brimblecombei Moore is an invasive insect pest that primarily targets Eucalyptus species, with a particular preference for Eucalyptus camaldulensis. The mechanism of host selection involves the recognition of host volatiles by odorant binding proteins (OBPs), which play crucial roles in various insect behaviors, including intersexual communication, oviposition, and interactions with host plants. The objective of this study was to identify the phytochemicals responsible for this host preference. The chemical composition of the essential oil extracted from the infested leaves of E. camaldulensis Dehnh. was analyzed using gas chromatography-mass spectrometry, revealing a total of 66 compounds that accounted for approximately 97.218% of the total oil. The major components identified were p-Cymene (29.78%), β-Phellandrene (15.55%), and Crypton (9.34%). Among the 66 volatiles detected, nine compounds, including Farnesol, Nirolidol, (Z,Z)-Farnesal, (Z,E)-Farnesal, Valerenol, β-Cubebene, cis-Linaloloxide, trans-Linalool oxide, and L-Linalool, exhibited the lowest Gibbs free energy (ΔG) values, ranging from -7.74 to -6.84 kcal/mol and favorable interactions with the hydrophobic cavity of the OBP CcapOBP22. Molecular dynamics simulations indicated that the docked models with (Z,E)-Farnesal, cis-Linaloloxide, and β-Cubebene were flexible and stable. This study may inform future pest management strategies targeting G. brimblecombei.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00435"},"PeriodicalIF":2.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Essence of Nature Can Be the Simplest (7)-Plant Growth: Powered by Extracellular Fenton Chemistry. 自然的本质可以是最简单的(7)-植物生长：由细胞外芬顿化学提供动力。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-15 DOI: 10.1002/cbdv.202502886

Xuemei Niu

{"title":"The Essence of Nature Can Be the Simplest (7)-Plant Growth: Powered by Extracellular Fenton Chemistry.","authors":"Xuemei Niu","doi":"10.1002/cbdv.202502886","DOIUrl":"https://doi.org/10.1002/cbdv.202502886","url":null,"abstract":"Plants serve as fundamental engineers of the biosphere, orchestrating processes essential for planetary function and the sustenance of life. They exhibit a notable morphological paradox: Aboveground structures (primarily photosynthetic shoots) display remarkable diversity in architecture and organ specialization, whereas belowground structures (primarily heterotrophic roots) often demonstrate striking conservation and convergence across phylogenetically distant taxa. This article synthesizes current knowledge on the dynamic patterns of ATP in photosynthetic and heterotrophic tissues driven by diurnal cycles, as well as variations in iron concentrations across different plant organs and tissues. By integrating molecular, physiological, and thermodynamic perspectives, the article proposes that shoots transition from ATP synthesis during the day to extensive extracellular Fenton chemistry at night, thereby coping with the substantial temperature decline. In contrast, roots, buffered by the insulating properties of soil, experience relatively minor fluctuations in the intensity of extracellular Fenton chemistry. Furthermore, critical life cycle transitions, including germination and flowering, are strongly influenced by extracellular Fenton chemistry. Elucidating the energetic mechanisms underlying these dynamic processes is essential for understanding plant biodiversity, advancing sustainable resource management, and enhancing plant adaptability in extreme environments, and revealing the chemical and energy rationales underlying the therapeutic principles of Traditional Chinese Medicine for disease treatment.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02886"},"PeriodicalIF":2.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic Insights Into the Effect of the Essential Oil of Ambrosia hispida Pursh. Against Multidrug-Resistant Clinical Isolates of Acinetobacter baumannii. 海参精油作用机理的研究。鲍曼不动杆菌临床多重耐药分离株的研究。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-13 DOI: 10.1002/cbdv.202502050

Haziel Eleazar Dzib-Baak, Gloria María Molina-Salinas, Andrés Humberto Uc-Cachón, Sergio Nemorio Hidalgo-Figueroa, Ángel Dzul-Beh, Carlos Javier Quintal-Novelo, Jesús Alfredo Araujo-León, Luz María Calvo-Irabien

{"title":"Mechanistic Insights Into the Effect of the Essential Oil of Ambrosia hispida Pursh. Against Multidrug-Resistant Clinical Isolates of Acinetobacter baumannii.","authors":"Haziel Eleazar Dzib-Baak, Gloria María Molina-Salinas, Andrés Humberto Uc-Cachón, Sergio Nemorio Hidalgo-Figueroa, Ángel Dzul-Beh, Carlos Javier Quintal-Novelo, Jesús Alfredo Araujo-León, Luz María Calvo-Irabien","doi":"10.1002/cbdv.202502050","DOIUrl":"https://doi.org/10.1002/cbdv.202502050","url":null,"abstract":"The emergence of antimicrobial-resistant bacteria has significantly compromised global public health. The World Health Organization has identified priority pathogens for research and new therapeutic strategies, highlighting carbapenem-resistant Acinetobacter baumannii as a critical priority. Ambrosia hispida essential oil (EO) from the Yucatan Peninsula was investigated for its anti-A. baumannii properties. GC-MS analysis identified 27 metabolites, predominantly sesquiterpenes and oxygenated sesquiterpenes, with spathulenol, caryophyllene oxide, and α-pinene as major compounds. This EO exhibited antibacterial activity against A. baumannii strains, strong inhibition of biofilm formation, and anti-quorum-sensing activity. Moreover, the EO also decreased bacterial survival in response to H2O2, indicating anti-catalase activity. Scanning electron microscopy (SEM) analysis confirmed the EO's ability to inhibit biofilm formation and cause morphological alterations in bacterial cells. Molecular docking studies revealed that kaurene, a diterpene in the EO, had the strongest interaction with bacterial targets involved in biofilm formation. The study highlights the potential of A. hispida EO as a promising candidate for developing agents to combat carbapenem-resistant A. baumannii.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02050"},"PeriodicalIF":2.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organ-Specific Profiling of Secondary Metabolites in Gentiana scabra Bunge via Molecular Networking-based Liquid Chromatography/Mass Spectrometry. 基于分子网络的液相色谱/质谱分析龙胆次生代谢物的器官特异性分析。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-13 DOI: 10.1002/cbdv.202501457

Siman Gu, Rui Li, Jiao Yin, Liping Ruan, Qing Shu, Anzhong Peng, Haifeng Li

{"title":"Organ-Specific Profiling of Secondary Metabolites in Gentiana scabra Bunge via Molecular Networking-based Liquid Chromatography/Mass Spectrometry.","authors":"Siman Gu, Rui Li, Jiao Yin, Liping Ruan, Qing Shu, Anzhong Peng, Haifeng Li","doi":"10.1002/cbdv.202501457","DOIUrl":"https://doi.org/10.1002/cbdv.202501457","url":null,"abstract":"Gentiana scabra Bunge (G. scabra), a perennial herb of Gentianaceae, has long been valued in East Asian medicine for its dried roots used to treat various ailments. However, root-based utilization alone cannot meet the growing clinical demand. This study systematically investigated the diversity and organ-specific distribution of secondary metabolites in G. scabra to support the sustainable use of the non-medicinal parts. Six bioactive compounds were quantified in roots and rhizomes (R), stems (S), leaves (L), and flowers (F) by ultra-performance liquid chromatography (UPLC), while UPLC coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry enabled qualitative profiling. Significant organ-specific variations were observed: mangiferin was abundant in L, amarogentin was not detected in all parts of the organs, and other compounds were concentrated in R. In total, 33 metabolites were identified. Iridoids were primarily distributed in R, though a small proportion was also detected in S, while flavonoids, triterpenoids, and xanthones were mainly found in the aerial parts (S, L, and F, respectively). These findings reveal pronounced metabolic differentiation among the organs of G. scabra and provide a scientific basis for the rational exploitation of non-medicinal parts, supporting the broader application of whole-plant utilization in traditional medicine.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01457"},"PeriodicalIF":2.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Elucidation of the Biochemical Activity and Phytochemical Content of an Uninvestigated Valuable Species: Anthemis tricornis Eig. 一种未被研究的珍贵物种——三角菊的生化活性和植物化学成分的综合研究。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-13 DOI: 10.1002/cbdv.202500890

Mustafa Abdullah Yilmaz, Alaa Hasan, Oguz Cakir

{"title":"Comprehensive Elucidation of the Biochemical Activity and Phytochemical Content of an Uninvestigated Valuable Species: Anthemis tricornis Eig.","authors":"Mustafa Abdullah Yilmaz, Alaa Hasan, Oguz Cakir","doi":"10.1002/cbdv.202500890","DOIUrl":"https://doi.org/10.1002/cbdv.202500890","url":null,"abstract":"This study presents the first comprehensive investigation of the Turkish endemic species Anthemis tricornis Eig, encompassing the quantitative profiling of its bioactive phytochemicals using a validated LC-MS/MS method, along with the assessment of its antioxidant properties and enzyme inhibitory activities. Quercetin (1.47 mg/g extract), cosmosiin (6.45 mg/g extract), chlorogenic acid (5.89 mg/g extract), quinic acid (24.01 mg/g extract), cynaroside (14.13 mg/g extract), and luteolin (1.92 mg/g extract) were found in the species' EtOH extract at surprisingly high concentrations, as shown by LC-MS/MS data. In addition, the species' total phenolic and flavonoid contents were found to be significantly high (57.88 ± 0.53 mg GAEs/g extract and 41.16 ± 0.21 mg REs/g extract, respectively). Fe3+-Fe2+, CUPRAC, Fe3+-TPTZ, DPPH, ABTS, and DMPD radical scavenging tests were used to measure antioxidant activity. The study found that the ethanol extract of A. tricornis had intermediate reducing power and radical-scavenging properties compared to natural and synthetic counterparts such as Trolox, α-tocopherol, BHA, and BHT. Inhibitory studies were conducted on acetylcholinesterase (AChE), α-amylase, and human carbonic anhydrase II (hCA II) enzymes, with IC50 values obtained for each enzyme. The study demonstrated that the extract moderately reduced hCA II, AChE, and α-amylase activity, with higher IC50 values than acetazolamide, tacrine, and acarbose.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00890"},"PeriodicalIF":2.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antifungal Activity of Polyalthic Acid Analogs Against Cryptococcus neoformans Involves Production of Reactive Oxygen Species (ROS) and Disruption of Cell Membrane Integrity. 聚胆酸类似物对新生隐球菌的抗真菌活性涉及活性氧（ROS）的产生和细胞膜完整性的破坏。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-13 DOI: 10.1002/cbdv.202502678

Thomas A Mennella, Kyung U Hong, Joshua Bojito, Thomas R Roche, Eun-Jung Park, Ariana B Souza, Rodrigo C S Veneziani, Sérgio R Ambrósio, Jairo K Bastos, Suresh Annam, Cassia S Mizuno

{"title":"Antifungal Activity of Polyalthic Acid Analogs Against Cryptococcus neoformans Involves Production of Reactive Oxygen Species (ROS) and Disruption of Cell Membrane Integrity.","authors":"Thomas A Mennella, Kyung U Hong, Joshua Bojito, Thomas R Roche, Eun-Jung Park, Ariana B Souza, Rodrigo C S Veneziani, Sérgio R Ambrósio, Jairo K Bastos, Suresh Annam, Cassia S Mizuno","doi":"10.1002/cbdv.202502678","DOIUrl":"https://doi.org/10.1002/cbdv.202502678","url":null,"abstract":"Invasive fungal infections have a high mortality rate, and the current antifungal arsenal is limited by toxicity, resistance, and the small number of available drugs. Polyalthic acid is a natural product with modest antifungal activity and low toxicity. Therefore, it is a suitable candidate for structural modification to enhance its antifungal activity. Six polyalthic acid analogs were synthesized, and their activity was tested against Candida albicans and Cryptococcus neoformans. The best compound was 2b with MICs of 21.8 and 12.3 µg/mL, respectively. We further investigated the mechanism of action of 2b by assessing its effects on ROS production and plasma membrane integrity in C. neoformans. Intracellular ROS levels were measured using H2DCFH-DA, while membrane integrity was evaluated using DAPI staining. A significant increase in ROS generation was detected at concentrations ≥ 4 µg/mL as early as 1 h after treatment. DAPI intensity and focal staining pattern were observed at all concentrations tested after 7.5 h of treatment. These findings indicated that the antifungal activity of 2b involves reactive oxygen species production and disruption of membrane integrity. The current study supports 2b as a potential lead compound for the development of new antifungal agents to address the limitations of current therapies.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02678"},"PeriodicalIF":2.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenolic Profiles, Mineral Compositions, and Solvent-Driven Antioxidant Potentials of Two Robinia Species. 两种刺槐的酚类特征、矿物组成和溶剂驱动的抗氧化电位。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-13 DOI: 10.1002/cbdv.202500547

Betül Kara Aktürk, Nesibe Arslan Burnaz

{"title":"Phenolic Profiles, Mineral Compositions, and Solvent-Driven Antioxidant Potentials of Two Robinia Species.","authors":"Betül Kara Aktürk, Nesibe Arslan Burnaz","doi":"10.1002/cbdv.202500547","DOIUrl":"https://doi.org/10.1002/cbdv.202500547","url":null,"abstract":"The genus Robinia, which belongs to the Fabaceae family, is a source of polyphenols and may be medicinally and pharmacologically effective against life-threatening diseases. This study investigated and compared the phenolic profiles, mineral contents, and antioxidant activities of two Robinia species. The antioxidant activities and phenolic/flavonoid contents of aerial parts of Robinia pseudoacacia and Robinia × ambigua plants at various solvents and concentrations were investigated in detail for the first time. The findings revealed that 50% acetone leaf extracts are promising sources of high phenol/flavonoid contents and antioxidant activity. Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) analysis allowed the identification of nine flavonoids and seven phenolic acids. Pelargonidin chloride, a common anthocyanidin with estrogenic activity, was the major component in all samples. Moreover, inductively coupled plasma-mass spectrometry (ICP-MS) shows that all samples were rich in K (12 886.70-26 078.11 mg/kg), Ca (1550.51-6011.03 mg/kg), and Mg (1676.13-3115.10 mg/kg). Leaves stand out compared to flowers. It is considered that the results obtained may guide studies in the fields of medicine, cosmetics, pharmacology, and so forth.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00547"},"PeriodicalIF":2.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Terpenoid Compounds From Montanoa tomentosa Cerv. With Anti-inflammatory Potential. 蒙大拿毛茛属植物的萜类化合物。具有抗炎潜能。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-13 DOI: 10.1002/cbdv.202501896

Eric Jaziel Medrano-Sánchez, Ammy Joana Gallegos-García, Ricardo López-Rodríguez, Patricia Álvarez-Fitz, Manasés González-Cortazar, Maribel Herrera-Ruíz, Alejandro Zamilpa, Carlos Ernesto Lobato-García, Cristian Octavio Barredo-Hernández, Abraham Gómez-Rivera

{"title":"Terpenoid Compounds From Montanoa tomentosa Cerv. With Anti-inflammatory Potential.","authors":"Eric Jaziel Medrano-Sánchez, Ammy Joana Gallegos-García, Ricardo López-Rodríguez, Patricia Álvarez-Fitz, Manasés González-Cortazar, Maribel Herrera-Ruíz, Alejandro Zamilpa, Carlos Ernesto Lobato-García, Cristian Octavio Barredo-Hernández, Abraham Gómez-Rivera","doi":"10.1002/cbdv.202501896","DOIUrl":"https://doi.org/10.1002/cbdv.202501896","url":null,"abstract":"Montanoa tomentosa has been used in Mexican traditional medicine as a labor inducer and contraceptive, as well as for the treatment of pain after childbirth. In this sense, M. tomentosa is an important source of metabolites with potent anti-inflammatory activity. The objective of this work was to evaluate the anti-inflammatory activity of extracts: n-hexane (MtHex), ethyl acetate (MtAc), and methanol (MtMe), and compounds isolated from leaves of M. tomentosa. The anti-inflammatory effect was evaluated in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema model in mice. The compounds were structurally characterized using one- and two-dimensional nuclear magnetic resonance spectroscopy. The MtHex (1 mg/ear) reduced edema (61.16 ± 3.8%), showing a similar effect to indomethacin (70.02 ± 1.24%). From the MtHex extract, the following compounds were isolated and identified: β-sitosterol (1), stigmasterol (2), kaurenoic acid (3), grandiflorenic acid (4), taraxasterol (5), and 15-cinnamoylkaurenic acid (6). Compounds 5, 6, and the mixture of 3 and 4 were evaluated; compound 6 showed the most significant effect in the TPA model (79.05 ± 3.07%). These exploratory results demonstrate that M. tomentosa could be an important source of terpene-type metabolites such as kaurenoic acid derivatives and sterols with potential anti-inflammatory effects.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01896"},"PeriodicalIF":2.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0