Chemistry & Biodiversity最新文献

{"title":"Folic Acid Targeted Selenium-Curcumin Nanoparticles to Enhance Apoptosis in Breast Cancer Cells.","authors":"Fateme Davarani Asl, Pooria Mohammadi Arvejeh, Mehdi Rezaee, Javad Saffari-Chaleshtori, Fatemeh Deris, Atefeh Satari, Samira Asgharzadeh, Pegah Khosravian","doi":"10.1002/cbdv.202500183","DOIUrl":"https://doi.org/10.1002/cbdv.202500183","url":null,"abstract":"<p><p>Despite advancements in drug delivery, breast cancer remains a leading cause of mortality, and creating therapeutic systems that balance efficacy and safety remains a challenge. Selenium (Se) and curcumin (Cur) exhibit antioxidant and anticancer properties, but their efficient application in cancer therapy is complex. This study developed a targeted drug delivery system for 4T1 breast cancer cells using selenium nanoparticles (SeNPs) loaded with curcumin and coated with chitosan-folic acid (Cs-FA) to enhance targeting efficiency. The incorporation of Cs-FA and Cur increased nanoparticle size from 105 to 184.2 nm and reduced 4T1 cell viability by 40% at a concentration of 40 µg/mL. The Cs-FA coating significantly enhanced apoptosis, as evidenced by upregulated p53 and downregulated BCL2 gene expression compared to other formulations. These results suggest that Se@Cur/Cs-FA nanoparticles effectively induce apoptosis, highlighting their potential as a promising cancer therapy.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00183"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a New Benzophenanthridine Alkaloid Suppressed the Growth and Migration of MDA-MB-231 Cells.","authors":"Yuxiang Wan, Yuxin Qi, Xueshuang Huang, Yang Xie, Peng Yang","doi":"10.1002/cbdv.202500936","DOIUrl":"https://doi.org/10.1002/cbdv.202500936","url":null,"abstract":"<p><p>Natural products remain a critical reservoir of lead compounds in the search for effective antimetastatic therapies for breast cancer. In the present study, we evaluated the inhibitory effects of three benzophenanthridine alkaloids against human breast cancer cells. One new benzophenanthridine alkaloid, (6S)-6-β-d-glucopyranosylsanguinarine (SGG, 1), was isolated and identified from Eomecon chionantha, and decreased the cell viability of MDA-MB-231 cells with an IC₅₀ value of 32.688 µM, while showing limited toxicity in normal liver cells. SGG significantly inhibits the migration ability in MDA-MB-231 cells using wound healing assay. Furthermore, molecular docking studies revealed significant interactions between SGG and FN1, COL3A1, DCN, MUC1 with a binding energy of -8.98, -7.79, -7.49, and -7.77 kcal/mol, respectively. According to ADMET and drug-likeness assessment, SGG was identified as a promising candidate lead compound. Collectively, these findings identify SGG as a potential small-molecule inhibitor of breast cancer metastasis.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00936"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UPLC-ESI-QTOF-MS/MS Profiling, Antioxidant, and Cytotoxicity Potentials of Marrubium vulgare L. Extracts: Experimental Analysis and Computational Validation.","authors":"Ines El Mannoubi, Nuha M Alghamdi, Seham H Bashir, Suada Alsaied Mohamed, Hedia Chaabane, Ashraf N Abdalla, Majdi Abid, Adel Kadri, Mozaniel Santana de Oliveira","doi":"10.1002/cbdv.202500400","DOIUrl":"https://doi.org/10.1002/cbdv.202500400","url":null,"abstract":"<p><p>Plant extracts are emerging as valuable options for food additives and therapeutic treatments. This study evaluated the phytochemical profile, antioxidant activity, and cytotoxicity of aerial parts of Marrubium vulgare L. crude extract (MVCE) and its subfractions. The MVCE (80% ethanol) contained steroids, phenolic compounds, flavonoids, terpenes, and cardiac glycosides, with total phenolic content (TPC) and total flavonoid content (TFC) of 14.96 ± 0.12 mg GAE/g DW and 12.27 ± 0.63 mg RE/g DW, respectively. All MV extracts exhibited potent antioxidant activity against DPPH^• (0.106-1.864 mg/mL) and ABTS^+• (0.298-17.084 mg/mL). The MV residual aqueous fraction (MVRF) showed significant cytotoxicity against human cancer cell lines, including MCF7 (IC₅₀ = 5.47 ± 1.32 µg/mL), HT29 (IC₅₀ = 17.48 ± 1.47 µg/mL), and SW480 (IC₅₀ = 7.51 ± 0.36 µg/mL). Ultra-performance liquid chromatography-mass spectrometry identified 26 bioactive compounds, with malic acid, caffeic acid, chlorogenic acid, kaempferol-3-glucuronide, and l-tryptophan as the major ones. Molecular docking revealed strong binding affinities of the above compounds to breast (PDB ID: 6CHZ) and colorectal cancer (PDB ID: 1HVY) proteins. Pharmacokinetic and toxicological studies confirmed their safety and efficacy, supporting MVRF as a potential therapeutic agent. These findings highlight MV as a promising candidate for future anticancer research.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00400"},"PeriodicalIF":2.3,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Soil Characteristics on the Phytochemistry of Evergreen Ivy (Hedera helix L.) Leaves in Deciduous Forests.","authors":"Elif Begüm Yıldırım, Gülçin Özer, Nisa Beril Sen, Emrah Özdemir, Ender Makineci, Durmuş Özdemir, Etil Guzelmeric","doi":"10.1002/cbdv.202403044","DOIUrl":"https://doi.org/10.1002/cbdv.202403044","url":null,"abstract":"<p><p>The evergreen ivy (Hedera helix L.), traditionally used to treat respiratory conditions, contains triterpene saponins, primarily hederacoside C, and various phenolic compounds. This study investigated the relationships between the chemical composition of ivy leaves and their natural growing conditions (moisture, temperature, pH, and electrical conductivity of soil). Ivy leaves were collected monthly over 1 year from oak and beech forests. Hederacoside C, rutin, chlorogenic acid (ChA), neoChA, 4,5-dicaffeoylquinic acid (DCQA), and 3,5-DCQA were analyzed by high-performance thin-layer chromatography (HPTLC) and high-performance liquid chromatography (HPLC). Soil parameter data, along with the quantitative HPLC results of ivy leaves, were first subjected to bivariate analysis, which revealed significant correlations, particularly between soil moisture, soil temperature, and the chemical composition of ivy leaves. In addition, ivy samples were classified and clustered based on seasons by principal component analysis (PCA) and hierarchical cluster analysis (HCA), regardless of their collection sites. Digitized HPTLC chromatograms were evaluated by PCA and partial least squares discriminant analysis (PLS-DA) analyses; PCA enabled the grouping of ivy leaves based on their collection sites, and PLS-DA categorized the samples by seasons. The evaluation of the relationships between the phytochemistry of ivy leaves and their natural growing conditions has been reported for the first time.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e03044"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Synthesis and Anticancer Activity of Naphthoquinone Fused Dihydropyridine Derivatives: In Silico and In Vitro Studies.","authors":"Ujjain Chaurasia, Tasneem Parvin, H M Chandra Mouli, Ramalingam Peraman, Abhishek Sahu","doi":"10.1002/cbdv.202500417","DOIUrl":"https://doi.org/10.1002/cbdv.202500417","url":null,"abstract":"<p><p>In pursuit of novel anticancer agents, herein we have designed and synthesized novel benzoyl-linked dihydropyridine derivatives fused with naphthoquinone moiety (4a-4h) through a one-pot multicomponent reaction of aryl glyoxal, acyclic 1,3-dicarbonyl compounds and 2-amino-1,4-naphthoquinone in acetic acid under reflux condition. Characterization was done by Fourier-transform infrared, proton nuclear magnetic resonance (¹H NMR), carbon-13 NMR (¹³C NMR), high-resolution mass spectrometry and single crystal X-ray diffraction. Subsequently, we conducted comprehensive molecular docking studies, focusing primarily on the STAT pathway, an important signalling cascade associated with breast cancer. The Protein Data Bank provided the structural coordinates for the pertinent proteins in this work, which were 2J6M, 3ERT, 4DRH, 1M17, 5ZAD and 1H6V. Our results offer strong scientific support for compounds 4a, 4c and 4d as promising candidates for breast cancer treatment. The synthesized compounds were then rigorously evaluated in vitro for their inhibitory effects on MCF-7 breast cancer cell lines. Among the tested compounds, 4c and 4d showed the most promise, exhibiting strong potency with notable inhibitory activity. Their half-maximal inhibitory concentration (IC₅₀) values were determined to be 4.54 and 17.48 µM, respectively, whereas the standard drug tamoxifen exhibited an IC₅₀ of 9.25 µM. These results highlight the significant potential of these compounds as therapeutic agents for breast cancer treatment.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00417"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Inflammatory Activity of Sarcoaldosterol A Isolated From Heteroxenia fuscescens: Insights From In Vitro, In Silico, and Spectroscopic Studies.","authors":"Rwaida A Al Haidari, Fahd M Abdelkarem, Bandar D Alrehaili, Aisha Alhaddad, Abdelaziz A A El-Sayed, Waad A Samman, Mahmoud A H Mostafa","doi":"10.1002/cbdv.202501069","DOIUrl":"https://doi.org/10.1002/cbdv.202501069","url":null,"abstract":"<p><p>Chronic inflammation is a key factor in the progression of many diseases, driving ongoing efforts to identify new and effective anti-inflammatory agents. Sarcoaldosterol A, a polyhydroxylated gorgostane steroid isolated from Heteroxenia fuscescens, was evaluated for its anti-inflammatory activity using in vitro studies, molecular docking, and quantum chemical calculations. Its structure was elucidated on the basis of 1D NMR, HR-ESI-MS, and comparison with literature. Sarcoaldosterol A significantly inhibited pro-inflammatory mediators nuclear factor-kappa B (NF-κB), tumor necrosis factor (TNF-α), interleukin-1 beta (IL-1β), and Toll-like receptor 4 (TLR-4), while upregulating the anti-inflammatory cytokine interleukin-10 (IL-10). It also showed moderate inhibition of cyclooxygenase-2 (COX-2) (IC₅₀ = 18.57 ± 0.61 µg/mL). Molecular docking confirmed COX-2 binding affinity, and quantum calculations elucidated its chemical stability and reactivity. As the first reported polyhydroxylated gorgostane steroid with such activity, Sarcoaldosterol A holds promising candidate for future exploration as a molecular scaffold in inflammation-related drug discovery.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01069"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Synthesis, Biological Evaluation, and Computational Studies of Pyrazine-1,3,4-Oxadiazole Analogs as Potential Antitubercular Agents.","authors":"Asha Ganesh Suryawanshi, Chandni Pathak, Pratik Khona, Ashish Jain, Uma Dhiraj Kabra","doi":"10.1002/cbdv.202500777","DOIUrl":"https://doi.org/10.1002/cbdv.202500777","url":null,"abstract":"<p><p>Tuberculosis (TB) remains a major global health threat, with Mycobacterium tuberculosis (Mtb) causing high morbidity and mortality. The rise of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) necessitates novel therapeutics with improved efficacy and safety. Among heterocyclic frameworks, pyrazine and oxadiazole derivatives have shown promising antimycobacterial activity. Pyrazinamide is a key pyrazine-based drug, whereas 1,3,4-oxadiazoles exhibit strong enzyme inhibition. In this study, a series of pyrazine-1,3,4-oxadiazole derivatives were synthesized and characterized using infrared (IR), mass spectrometry, nuclear magnetic resonance (NMR), and elemental analysis. Their antitubercular activity was evaluated against the Mtb H₃₇Rv strain using the microplate alamar blue assay (MABA). The compounds exhibited minimum inhibitory concentration (MIC) values ranging from 3.13 to 12.5 µg/mL (9.39-55.75 µM). Notably, compounds 2e, 2f, and 2n exhibited the highest potency, attributed to halogen substitutions that enhanced lipophilicity and target interactions. Molecular docking studies reinforced these results, with compound 2f demonstrating a strong binding affinity (-9.0 kcal/mol) for the DprE1 enzyme, surpassing standard anti-TB drugs, isoniazid (-5.3 kcal/mol) and rifampicin (-7.9 kcal/mol). In addition, molecular dynamics (MD) simulation results revealed that compound 2f exhibits superior structural stability, compactness, and consistent binding interactions with DprE1. These findings highlight the potential of pyrazine-oxadiazole hybrids as promising scaffolds for developing novel antitubercular agents.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00777"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clerodane Diterpenoids and Ecdysteroids From the Fruits of Tinospora sagittata (Oliv.) Gagnep.","authors":"Rong-Qing Yuan, Hai-Yin Wang, Zhou Liu, Lin Jia, Ya-Xuan Ma, Run-Cheng Yan, Shi-Huan Yin, Wen-Chao Tu, Ming Hu, Lin-Fen Ding, Xing-De Wu","doi":"10.1002/cbdv.202501502","DOIUrl":"https://doi.org/10.1002/cbdv.202501502","url":null,"abstract":"<p><p>A new clerodane-type diterpenoid, tinosaginoside A (1), and two new ecdysteroids, tinosagisterones A and B (8 and 9), were isolated from the fruits of Tinospora sagittata (Oliv.) Gagnep., as well as and nine previously reported compounds (2-7 and 10-12). The structures and absolute configurations of 1, 8, and 9 were elucidated through comprehensive spectroscopic analyses, including two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and infrared spectroscopy, as well as electronic circular dichroism calculations. Structurally, compound 8 is a rare ecdysteroid featuring a hexadienone unit, and 9 is an unprecedented ecdysteroid characterized by an oxygen bridge between C-2 and C-9. Additionally, compound 7 exhibited moderate inhibitory activity against nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells, with an IC₅₀ value of 35.78 ± 0.37 µM, compared to the positive control, N^G-monomethyl-L-arginine, which had an IC₅₀ value of 40.28 ± 0.48 µM.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01502"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-Based Copper Oxide Nanocatalyst for Sustainable High-Quality Biofuel Production: RSM-Facilitated Optimization and Kinetics Study.","authors":"K V Pradeep, K P Ravikumar, K Santhosh, C S Kavitha, T P Jeevan, K V Yatish","doi":"10.1002/cbdv.202500621","DOIUrl":"https://doi.org/10.1002/cbdv.202500621","url":null,"abstract":"<p><p>The Michelia champaca plant's leaves and seeds are used in this study as environmentally acceptable resources to produce copper oxide nanoparticles (CuO NPs) and biodiesel, respectively. M. champaca leaf extract is used as a reducing and fuel agent in the solution combustion process to synthesize the CuO NPs. Fourier transform infrared (FTIR) spectroscopy, x-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM) and Brunauer-Emmett-Teller (BET) methods were used to characterize the CuO NPs and used as an effective catalyst in the manufacture of biodiesel utilizing M. champaca oil (MCO) as the feedstock under various reaction conditions. The results exhibited a monoclinic crystal structure with a spherical shape. The surface area of CuO NPs was found to be 13.27 m²/g, the pore diameter was 23.4 nm and the pore volume was 0.04725 cm³/g. Two-step transesterification, that is, esterification followed by transesterification, is conducted for MCO. To optimize the biodiesel production parameters, response surface methodology (RSM) with the central composite design algorithm is used. The maximum yield of M. champaca methyl ester (MCME), 97.35%, was obtained at 60°C, stirring at 650 rpm, with a reaction period of 64 min, a CuO concentration of 3 wt.% and a methanol-to-oil (M/O) molar ratio of 8.94:1 predicted through RSM. For up to four cycles, the CuO NPs exhibited excellent catalytic stability, with only a little reduction in biodiesel output (86.3%). An activation energy (Ea) of 41.69 kJ/mol and a frequency factor (A) of 1.5 × 10⁵ min^-1 obtained through pseudo-first-order reaction, which is the result of kinetic analysis of MCME synthesis. ¹H NMR and FTIR were used to further evaluate the MCME. It was discovered that MCME's fuel qualities met ASTM requirements. Metrics related to green chemistry are also included. Green chemistry measures, such as environmental factor (E-factor), atom efficiency, atom economy and solvent and catalyst environmental effect parameter, have been investigated.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00621"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Compounds and Biological Activities of Sarcomphalus joazeiro (Mart.) Hauenschild.","authors":"Natália Kelly Gomes de Carvalho, Mariana Pereira da Silva, Débora Odília Duarte Leite, Fabiola Fernandes Galvão Rodrigues, José Galberto Martins da Costa","doi":"10.1002/cbdv.202500700","DOIUrl":"https://doi.org/10.1002/cbdv.202500700","url":null,"abstract":"<p><p>Sarcomphalus joazeiro (Mart.) Hauenschild (Rhamnaceae), commonly referred to as \"juá\" or \"joazeiro,\" is a native and endemic species of the Brazilian semiarid region. This review aims to compile all information on the ethnobotanical, chemical, biological, and biotechnological aspects of the species, including data on patents. The methodology employed involved an integrative review of all published literature from 1984 to 2024. As a result, 25 articles and 18 patents were selected for this study. The species demonstrated antioxidant, antimicrobial, anxiolytic, and gastroprotective activities, among others. These bioactivities are attributed to the presence of saponins and flavonoids, main constituents of its bark and leaves, respectively. Pharmacokinetic studies suggest that nanoformulation systems can increase the solubility and absorption of these bioactive compounds. Notably, patented products derived from S. joazeiro are targeted at the food, cosmetic, and personal hygiene industries. Future research on this species is necessary to evaluate the toxicological profile, isolation of compounds, mechanisms of action, and bioavailability.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00700"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}