Yasmina Jaouhari, Hamid Kabdy, Ouijdane El Hatimy, Hajar Azraida, Baslam Abdelmounaim, Abdelfattah Aitbaba, Laadraoui Jawad, Yassine Chait, Rachida Aboufatima, Soad Moubtakir, Loubna El Yazouli, Stefania Garzoli, Abderrahman Chait
{"title":"Anti-inflammatory and Gastroprotective Effects of the Chamaerops humilis L. (DOUM) Fruit Aqueous Extract in Experimental Models of Edema and Gastric Ulcer.","authors":"Yasmina Jaouhari, Hamid Kabdy, Ouijdane El Hatimy, Hajar Azraida, Baslam Abdelmounaim, Abdelfattah Aitbaba, Laadraoui Jawad, Yassine Chait, Rachida Aboufatima, Soad Moubtakir, Loubna El Yazouli, Stefania Garzoli, Abderrahman Chait","doi":"10.1002/cbdv.202403241","DOIUrl":"https://doi.org/10.1002/cbdv.202403241","url":null,"abstract":"<p><p>Chronic inflammation can lead to various diseases, including gastric ulcers, highlighting the need for effective therapeutic strategies. The traditional use of Chamaerops humilis in Moroccan folk medicine for treating gastrointestinal disorders underscores its potential as a valuable natural remedy. This study rigorously evaluates the anti-inflammatory and gastroprotective effects of the aqueous extract of Chamaerops humilis (AECH) through a series of well-established animal models, including carrageenan-induced paw edema, xylene-induced ear edema, and ethanol/HCl-induced gastric ulcers. The results reveal that AECH significantly reduces inflammation and ulcer severity in a dose-dependent manner, demonstrating potent efficacy in decreasing paw and ear edema while markedly mitigating ulceration induced by ethanol/HCl exposure. Notably, AECH achieved up to 100% inhibition of ulcer lesions at higher doses. These findings not only validate the traditional applications of Chamaerops humilis but also highlight its promising role as a natural therapeutic agent for managing inflammatory conditions and gastric ulcers.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202403241"},"PeriodicalIF":2.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahathir Mohammad, Fahmida Tasnim Richi, Md Arafat, Pair Ahmed Jiko, Mohammad Rashedul Haque, Md Hemayet Hossain, Md Sakhaoyat Hossain, Sania Ashrafi, Mohammad Abdullah Taher, Safaet Alam
{"title":"Amelioration of hepatic injury through oxidative stress management employing methanolic extract of Crepe- ginger (Cheilocostus speciosus (J. Koenig) C. Specht) flower.","authors":"Mahathir Mohammad, Fahmida Tasnim Richi, Md Arafat, Pair Ahmed Jiko, Mohammad Rashedul Haque, Md Hemayet Hossain, Md Sakhaoyat Hossain, Sania Ashrafi, Mohammad Abdullah Taher, Safaet Alam","doi":"10.1002/cbdv.202500261","DOIUrl":"https://doi.org/10.1002/cbdv.202500261","url":null,"abstract":"<p><strong>Background: </strong>Cheilocostus speciosus (J. Koenig) C. Specht, commonly known as \"Crepe-ginger\", is a traditional plant with edible flowers utilized in folk medicine. This study employs crepe-ginger flowers to evaluate their role in boosting liver immunity, hepatoprotective actions through oxidative stress management.</p><p><strong>Methods: </strong>Cheilocostus speciosus flower's methanolic extract (CSF-ME) was subjected to In-vitro anti-oxidant effects were evaluated using DPPH and ABTS and in-vivo by catalase (CAT) assays which ameliorated CCl4-induced hepatic injury evident by histopathological analysis. The chemical assay was evaluated via phytochemical screening and GC-MS/MS analysis followed by in-silico studies.</p><p><strong>Results: </strong>The antioxidant assay DPPH (IC50 =179.36 µg/ml) and ABTS (IC50 = 198.27 µg/ml) showed remarkable scavenging activity. Hepatotoxicity experiments demonstrated that CSF-ME improved liver function by positively regulating AST, ALT, ALP, bilirubin, creatinine, LDL, CHO, TG, HDL, and catalase levels. Besides, histopathological analysis revealed normal hepatocyte integrity and microstructures after treatment. Besides, phytochemical screening revealed prospective phytochemical groups while GC-MS/MS analysis recognized forty compounds resulting in auspicious outcomes employing computer-aided studies.</p><p><strong>Conclusion: </strong>The findings indicated that the CSF-ME possesses promising hepatoprotective, and antioxidant prospects which demand further extensive research to develop novel lead compounds from this natural source.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202500261"},"PeriodicalIF":2.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khalid Zoghebi, Zia Ur Rehman, Hassan A Alhazmi, Mohammed Albratty, Asim Najmi, Sivakumar S Moni, Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Asaad Khalid, Abdullah Algaissi, Magbool Essa Oraiby, Wafa Ibrahim Qumayri, Faridah Hussain Al-Agsam
{"title":"Computational Insights into the Binding Potential of Natural Products against Pseudomonas aeruginosa Metallo-beta-lactamase VIM-1 to Combat Antibiotic Resistance.","authors":"Khalid Zoghebi, Zia Ur Rehman, Hassan A Alhazmi, Mohammed Albratty, Asim Najmi, Sivakumar S Moni, Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Asaad Khalid, Abdullah Algaissi, Magbool Essa Oraiby, Wafa Ibrahim Qumayri, Faridah Hussain Al-Agsam","doi":"10.1002/cbdv.202500161","DOIUrl":"https://doi.org/10.1002/cbdv.202500161","url":null,"abstract":"<p><p>Metallo-beta-lactamase VIM-1 significantly contributes to bacterial resistance against beta-lactam antibiotics, including carbapenems, in Pseudomonas aeruginosa, leading to high morbidity and mortality, especially in immunocompromised individuals. The bacterium's ability to evade many antibiotics poses a significant challenge, necessitating novel inhibitors to treat such infections. This study uses a computational approach to identify VIM-1 inhibitors from the Molport library of natural compounds. Three promising compounds-ZINC000044404209, ZINC000038140885, and ZINC000037538575-were selected through virtual screening based on high docking scores and Lipinski filter application. Re-docking confirmed their interactions with VIM-1's active site. Molecular Dynamics (MD) simulations revealed that ZINC000044404209 and ZINC000038140885 were structurally more stable than the control, shown by lower RMSD and RMSF values, stable hydrogen bonding, and compact radius of gyration values. Using the MMGBSA method, the calculations of free binding energy confirmed ZINC000038140885 had the most favorable binding energy of -108.13 kcal/mol, followed by ZINC000044404209 with -38.02 kcal/mol. These findings identify compounds with stronger binding and stability than existing controls, potentially serving as potent VIM-1 inhibitors. This in silico study provides valuable leads that warrant further experimental validation to develop new therapies against antibiotic-resistant P. aeruginosa.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202500161"},"PeriodicalIF":2.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"South African Propolis: Anti-Helicobacter pylori Activity, Chemistry, and Toxicity.","authors":"Sandy Van Vuuren, Sarhana Dinat, Ane Orchard, Efficient Ncube, Weiyang Chen, Alvaro Viljoen","doi":"10.1002/cbdv.202403200","DOIUrl":"https://doi.org/10.1002/cbdv.202403200","url":null,"abstract":"<p><p>Propolis, a resin-like substance produced by bees, has previously shown antimicrobial activity against the ulcer-causing gut pathogen, Helicobacter pylori. South African propolis, however, was yet to be investigated. This study aimed to investigate a comprehensive range of South African propolis for its antimicrobial activity against H. pylori and to investigate toxicity. A total of 51 samples were collected from around South Africa, and comparatively analysed with three Brazilian samples. The antimicrobial broth microdilution assay was used to determine the minimum inhibitory concentration (MIC) of ethanolic propolis extracts against three clinical H. pylori strains. A total of 27 South African propolis extracts presented antimicrobial activity better than that of the Brazilian samples (MIC ≤ 0.51 mg/mL). Samples with the best anti-H. pylori activity were selected for chemical analysis using ultra performance liquid chromatography-mass spectrometry. The compounds pinocembrin, 3-O-acetylpinobanksin, and pinobanksin were found to be most abundant. All propolis extracts investigated in this study were considered non-toxic (mortality < 50%) when investigated using the brine shrimp lethality assay. This study demonstrates the in vitro potential of utilizing propolis for treating H. pylori infections and highlights the possible compounds responsible for the activity observed.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202403200"},"PeriodicalIF":2.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Javier E Ortiz, Mauricio E Piñeiro, Marcel Kaiser, Pascal Mäser, Jaume Bastida, Gabriela Egly Feresin
{"title":"Anti-trypanosomatid and Antiplasmodial Activities of Alkaloids from Hippeastrum species.","authors":"Javier E Ortiz, Mauricio E Piñeiro, Marcel Kaiser, Pascal Mäser, Jaume Bastida, Gabriela Egly Feresin","doi":"10.1002/cbdv.202500015","DOIUrl":"https://doi.org/10.1002/cbdv.202500015","url":null,"abstract":"<p><p>Diseases caused by trypanosomatid parasites like human African trypanosomiasis (HAT), Chagas disease (CD), leishmaniasis, and malaria, are persistent health problems in developing countries that still demand for new drug development. The species of the Amaryllidoideae subfamily (Amaryllidaceae) represent a vast source of alkaloids with a wide range of bioactive properties, including antiparasitic effects. The aim of this study was to evaluate the antiparasitic activity of the alkaloids hamayne, 7-hydroxyclivonine, 4-O-methylnangustine, and candimine against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, and Plasmodium falciparum parasites. The alkaloids were isolated from the leaves of Hippeastrum argentinum and H. escoipense using several chromatographic techniques then identified by GC-MS, UPLC-MS/MS, and NMR data. The compounds were assessed against different life cycle stages of these four parasites. Furthermore, the cytotoxic activity of the alkaloids against L6 rat skeletal myoblast cells, was tested. P. falciparum was very sensible to 7-hydroxyclivonine. Candimine showed significant antiparasitic activity against all the evaluated parasites, especially T. brucei rhodesiense. Candimine merits deeper research regarding its effect against trypanosomatid parasites as a lead compound for the development of alternative treatments for HAT, CD, and malaria.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202500015"},"PeriodicalIF":2.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diversity of Endophytic Fungi Isolated from Huperzia Serrata and Research on the Secondary Metabolites of Penicillium panissanguineum SZSS 4-2-2.","authors":"Ya-Shuai Kang, Hao-Wen Zhu, Xue Zhao, Hao Ma, Yu Yang, Rui Xu, Fu-Yao Luo, Er-Wei Li, Qian Luo, You-Zhi Zhang, Chang-Wei Li","doi":"10.1002/cbdv.202500701","DOIUrl":"https://doi.org/10.1002/cbdv.202500701","url":null,"abstract":"<p><p>A total of 46 endophytic fungi were isolated from Huperzia serrata and then cultured in standard liquid medium and PDB medium. Cytotoxicity and antimicrobial activity assays revealed that seven crude extracts exhibited significant inhibitory effects on MCF-7 and SH-SY5Y cell lines; four crude extracts effectively inhibited the growth of Candida albicans, and 12 crude extracts demonstrated potent inhibition effect on Staphylococcus aureus. Strains displaying antimicrobial activity or potential for producing novel metabolites were selected for identification. In total, 14 strains representing 7 genera were identified, 5 of which had not been previously documented regarding their secondary metabolites. A fungus, Penicillium panissanguineum SZSS 4-2-2 was preliminarily selected for further chemical investigation. From the fermentation extract of P. panissanguineum SZSS 4-2-2, one new compound (1), one new natural product (2), and two known compounds (3 and 4) were isolated. The structures of these compounds were elucidated through spectral analysis and calculated NMR, ECD data. Compound 1 demonstrated a significantly stronger inhibitory effect on lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages, with an IC50 value of 64.91 μM. By contrast, compounds 2, 3 and 4 exhibited only moderate inhibitory effects on the NO production.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202500701"},"PeriodicalIF":2.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Merve Saylam, Fadime Aydın Kose, Gunes Coban, Huseyin Istanbullu
{"title":"Novel Triazolopyrimidinone Compounds as Inhibitors of Adipocyte Fatty Acid Binding Protein (FABP4).","authors":"Merve Saylam, Fadime Aydın Kose, Gunes Coban, Huseyin Istanbullu","doi":"10.1002/cbdv.202500205","DOIUrl":"https://doi.org/10.1002/cbdv.202500205","url":null,"abstract":"<p><p>Metabolic syndrome, characterized by a combination of high blood pressure, elevated blood glucose levels, high triglycerides, low HDL cholesterol, and abdominal obesity, significantly increases the risk of coronary heart disease, diabetes, and stroke. Fatty acid binding proteins (FABPs), particularly FABP4, play a crucial role in these processes, serving as lipid chaperones that regulate lipid responses in adipocytes and macrophages. Recent advances in FABP4 inhibitor (FABP4i) development have shown potential in improving insulin resistance and related metabolic conditions in experimental models. The design of new FABP4i compounds, particularly those based on the [1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one core structure, offers promising strategies for treating obesity-related metabolic disorders. In this study, a group of triazolopyrimidine-7-on derivatives was synthesized, and their FABP4 inhibitory activity was evaluated. Compound 1 was found to be the most active, with one-third the activity of arachidonic acid.\"</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202500205"},"PeriodicalIF":2.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Four Undescribed Sesquiterpenes from the Rhizomes of Curcuma wenyujin.","authors":"Lijia Chen, Hui Wang, Hong Wang, Shuyu Song, Yiming Li, Jingwen Liu, Fujiang Guo","doi":"10.1002/cbdv.202500068","DOIUrl":"https://doi.org/10.1002/cbdv.202500068","url":null,"abstract":"<p><p>A total of 16 sesquiterpenes were isolated from the rhizomes of Curcuma wenyujin, including four undescribed sesquiterpenes, namely wenyujinone J - M (1 - 4), and twelve known molecules (5 - 16). The structures of undescribed compounds were elucidated based on spectroscopic and spectrometric data analyses. Among them, wenyujinones J (1) and L (3) possessed undescribed sesquiterpenoid skeletons. In addition, all the isolated compounds were evaluated for their protective effect against hydrogen peroxide (H2O2)-induced injury in human hepatic L02 cells and for agonistic effect on farnesoid X receptors (FXR) situated with human embryonic kidney (HEK) 293T cells. As a result, compounds 7 and 9 (25 μM) markedly weakened the oxidative damage induced by H2O2 in L02 cells strengthening the cell viability of 72.28% and 74.14%, respectively. Compounds 1, 4 and 16 had a significant agonistic effect at 25 μM, while compounds 5, 7, 9, and 11-14 possessed moderate to weak agonistic effects at same concentration.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202500068"},"PeriodicalIF":2.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vibha Joshi, Vishwajeet Bachhar, Shashank Shekher Mishra, Ravi K Shukla, Neeraj Kumar, Manisha Duseja
{"title":"Identification of Potential Anticancer Phytochemicals of Piper chaba by Comprehensive Molecular Docking, Molecular Dynamics Simulation and In-Vitro Studies.","authors":"Vibha Joshi, Vishwajeet Bachhar, Shashank Shekher Mishra, Ravi K Shukla, Neeraj Kumar, Manisha Duseja","doi":"10.1002/cbdv.202403269","DOIUrl":"https://doi.org/10.1002/cbdv.202403269","url":null,"abstract":"<p><p>Human colon cancer and prostate cancer are the most common malignancy globally. Despite the availability of many treatments, resistance to traditional medicines, such as chemotherapy and radiotherapy, remains a severe obstacle in cancer treatment. Hence, searching for new therapeutic options is of utmost priority. The present investigation evaluates the in-silico and in-vitro anticancer potential of phytochemicals of Piper chaba. The cytotoxicity results demonstrated that the plant extract exhibited significant anticancer activity, with IC<sub>50</sub> values of 12.66 ± 0.25 µg/mL for HCT-116 and 19.49 ± 0.37 µg/mL for DU-145. Molecular docking and molecular dynamics simulations were performed to explore the interaction of potential drug targets with the phytochemicals. Subsequently, pharmacokinetic parameters calculations were performed to evaluate the drug-likeness. Piperine exhibits the highest binding affinity for vascular endothelial growth factor receptor-2 (VEGFR2) protein with a docking score of -9.71 kcal/mol. Sylvatine had a greater binding affinity for human epidermal growth factor receptor 3 (HER3) protein than the other phytochemicals. Isopiperine, chabamide, Piperlonguminine, Santamarine and Versalide only exhibited ligand activity for human IKK beta protein (inhibitor of kappa B kinase). Additionally, a principal component analysis was performed to strengthen the investigation's scope. These proposed phytochemicals are reported to possess potential VEGFR2, HER2 and human IKK beta inhibition. The best phytochemical hits have excellent binding affinity and hold a massive anticancer potential, opening up new avenues for prospective future investigations in cancer treatment.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202403269"},"PeriodicalIF":2.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Silu Hua, Ping Liu, Li Miao, Likui Zhang, Haibo Wang, Yanqing Liu, Dongdong Wang, Wei Jiang
{"title":"Neolignan and 3-Benzylchroman Derivatives From Celastrus orbiculatus Thunb.","authors":"Silu Hua, Ping Liu, Li Miao, Likui Zhang, Haibo Wang, Yanqing Liu, Dongdong Wang, Wei Jiang","doi":"10.1002/cbdv.202500273","DOIUrl":"https://doi.org/10.1002/cbdv.202500273","url":null,"abstract":"<p><p>Phytochemical investigation of the ethyl acetate extract of the stems of Celastrus orbiculatus Thunb. led to the isolation of a new neolignan, celastorbiol A (1), and two new homoisoflavones, celastrones A and B (2 and 3), along with five known 3-benzylchroman derivatives, including 7,4'-dihydrohomoisoflavanone (4), 3-deoxysappanone B (5), 3'-deoxysappanone A (6), bonducelin (7), and sappanone A (8). Their structures were determined based on extensive spectroscopic and spectrometric data analyses, and computational studies. Compounds 1, 6, and 8 exhibited cytotoxic activities against human gastric cancer AGS and HGC-27 cell lines with IC<sub>50</sub> values that ranged from 42.82 ± 0.98 to 98.04 ± 1.33 µM.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202500273"},"PeriodicalIF":2.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}