Chemistry & Biodiversity最新文献

{"title":"Anxiolytic and Memory Protective Effects of Withanolide D Isolated From Acnistus arborescens in Adult Zebrafish.","authors":"Cléia Rocha de Sousa Feitosa, Joilna Alves Da Silva, Jéssica Bezerra Maciel, Ivana Carneiro Romão, Thais Rocha Cavalcante, Francisco Anderson Nascimento Barros, Nicole de Abreu Bandeira, Emmanuel Silva Marinho, Jane Eire Silva Alencar De Menezes, Maria Kueirislene Amâncio Ferreira, Antonio Wlisses Da Silva, Márcia Machado Marinho, Matheus Nunes Da Rocha, Otília Deusdênia Loiola Pessoa, Pedro Henrique Jatai Batista, Andreia Ferreira De Castro Gomes, Alexandre Magno Rodrigues Teixeira, Hélcio Silva Dos Santos","doi":"10.1002/cbdv.202502272","DOIUrl":"10.1002/cbdv.202502272","url":null,"abstract":"<p><p>This study evaluated the anxiolytic and memory-protective effects of withanolide D in adult zebrafish (Danio rerio). The compound was administered at doses of 4, 20, and 40 mg/kg and showed no signs of toxicity after 96 h of observation at any of the doses tested. In the open field test, withanolide D reduced locomotor activity, indicating a sedative-like effect. Nevertheless, in the light/dark test, doses of 20 and 40 mg/kg produced an anxiolytic-like response, suggesting that anxiolytic and motor effects may partially overlap depending on dose. The anxiolytic effect observed at the minimum effective dose (20 mg/kg) was reversed by flumazenil (FMZ), supporting the involvement of a benzodiazepine-sensitive GABA_A modulatory domain. Furthermore, withanolide D, at a dose of 4 mg/kg, prevented ethanol-induced memory impairment in the inhibitory avoidance task, suggesting a protective effect on memory consolidation. Molecular docking analyses revealed favorable interactions of withanolide D at the extracellular α1γ2 interface of the GABA_A receptor, supporting a putative allosteric interaction in a functionally related modulatory region rather than definitive occupation of the classical diazepam site. Consistently, normal mode analysis (NMA) showed that withanolide D increases receptor mobility compared to diazepam, with RMSF values reaching up to 0.98 Å, indicating enhanced structural flexibility and dynamic modulation of the protein. Thus, these findings suggest that withanolide D has therapeutic potential for the treatment of anxiety, in addition to providing protective effects on memory.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 5","pages":"e02272"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating UHPLC-Q-TOF-MS, Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations to Reveal the Potential Mechanisms of Yiguanjian Decoction in Treating Liver Cancer.","authors":"Xiaoli Wen, Xinyuan Zhang, Wen Fang, Hongning Liu, Fangyan Cai","doi":"10.1002/cbdv.71293","DOIUrl":"https://doi.org/10.1002/cbdv.71293","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors worldwide. Both experimental and clinical studies confirm the anti-HCC effects of Yiguanjian (YGJ), though its material basis and pharmacological mechanisms remain unclear. This study integrated UHPLC-Q-TOF-MS with network pharmacology, molecular docking, and MDS to explore YGJ's potential anti-HCC mechanisms and active ingredients. In vitro analysis identified 96 chemical constituents in the YGJ extract, while network pharmacology revealed 57 potential targets and 51 bioactive compounds related to HCC treatment. The top nine key targets were AKT1, CTNNB1, EGFR, IL6, STAT3, BCL2, CASP3, MMP9, and TNF-α; the top seven active compounds included kaempferol, quercetin, luteolin, senkyunolide O, jasmolone, azaron, and dihydroartemisinin. These components may regulate HCC cell processes like gene expression, signal transduction, proliferation, apoptosis, and angiogenesis through pathways such as PI3K-Akt, TNF signaling pathway, and HIF-1 signaling pathway. Molecular docking and MDS showed that kaempferol, quercetin, luteolin, and dihydroartemisinin bind favorably to TNF-α, MMP9, BCL2, and IL6 proteins. Therefore, these proteins may serve as YGJ's therapeutic targets, while the compounds contribute to its pharmacological effects.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 5","pages":"e71293"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manganese Porphyrin-Catalyzed One-Pot Oxidation of Lupeol: Efficient Conversion of Its Terminal Alkene Into Carboxylic Acids.","authors":"Leila Renan Oliveira, Pedro Fonseca-Pinheiro, Lucienir Pains Duarte, Diogo Montes Vidal, Grasiely Faria de Sousa, Dayse Carvalho da Silva Martins","doi":"10.1002/cbdv.71239","DOIUrl":"https://doi.org/10.1002/cbdv.71239","url":null,"abstract":"<p><p>The PhI(OAc)₂-oxidation of the triterpene lupeol by manganese porphyrin was achieved, leading to 94% of lupeol conversion. Conditions aligned with principles of green chemistry, including the use of ethyl acetate as a solvent and iodobenzene diacetate as an oxidant, were studied. This approach led to the production of eight products from lupeol, notably achieving transformations at the C20 olefin moiety; six lupeol's products were isolated whereas the other two had their structures proposed supported on basic chemical tests (e.g., Fehling's test) and well‑established reactivity patterns in organic chemistry. These modifications were performed without the typical preceding protection of the C3 hydroxyl of lupeol, simplifying the synthetic route. Besides, the isopropenyl group of lupeol was converted to carboxylic acids through one-pot oxidation. This study reinforces the promising use of manganese porphyrins as catalysts for the oxidative transformation of other natural products of biological interest.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 5","pages":"e71239"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Chemical Constituents of Euphorbia tibetica and Their Bioactivities.","authors":"Tong Shen, Yunao Jin, Yinzhi Han, Zheng Gong, Zhaocai Li, Yilin He","doi":"10.1002/cbdv.71287","DOIUrl":"https://doi.org/10.1002/cbdv.71287","url":null,"abstract":"<p><p>In the phytochemical study of Euphorbia tibetica, one undescribed ring-opening secoiridoid ether terpenoid, named compound 1, along with 13 known compounds 2-14, was isolated. Their structures were elucidated by comprehensive spectroscopic analysis (HRESIMS, 1D, and 2D NMR) and comparison with published literature data. Biological research discovered that compounds 9 and 12 exhibited potent antichlamydial activity at 200 µM, while compounds 7 and 8 showed moderate activity against three different pathogenic fungi at 30 µg/mL. The results suggested that compounds 9 and 12 might be a promising class of therapeutic agents for chlamydial infections.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 5","pages":"e71287"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Evaluation of Isatin Analogs as Potential Urease and Tyrosinase Inhibitors: An Approach of Molecular Docking.","authors":"Guoyang Ma, Yawen Li, Shaohong Xu, Muhammad Tariq Javid, Naveed Ahmed, Usman Farooq","doi":"10.1002/cbdv.71285","DOIUrl":"https://doi.org/10.1002/cbdv.71285","url":null,"abstract":"<p><p>A series of isatin-based Schiff base derivatives (1-12) was synthesized via a two-step reaction and characterized using spectroscopic techniques such as ¹H-NMR and mass spectrometry. The urease and tyrosinase inhibitory activities of the synthesized compounds were evaluated using thiourea (IC50 = 21.25 ± 0.15 µM) and kojic acid (IC50 = 121 ± 0.5 µM) as standard inhibitors. Among the synthesized analogs, only three compounds-1 (IC50 = 38.9 ± 0.06 µM), 3 (IC50 = 56.7 ± 0.02 µM), and 10 (IC50 = 71 ± 0.09 µM) showed moderate urease inhibition, while the remaining compounds were inactive. All compounds were inactive against tyrosinase inhibition. The structure-activity relationship (SAR) of the active analogs was established based on the nature, position, and number of substituents on the phenyl ring of the basic nucleus of the compounds. Molecular docking studies were performed to confirm the binding interactions of the most potent analogs with the active site of urease. The docking results revealed that compound 1 formed six strong intermolecular interactions with the binding site residues of urease, exhibiting the lowest docking score of -4.8944. The findings suggest that the synthesized isatin-based Schiff base derivatives, particularly compounds 1, 3, and 10, could serve as potential lead compounds for developing novel urease inhibitors.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 5","pages":"e71285"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Origanum majorana L. Essential Oil in Diabetes Mellitus: Insights From GC-MS Characterization, In Vivo Hypoglycaemic Studies, and In Silico Analyses.","authors":"Mahmoud Houas, Mohammed Larbi Benamor, Elhafnaoui Lanez, Yahia Bekkar, Lotfi Bourougaa, Ouafa Boudebia, Rania Bouraoui, Aicha Adaika, Nafila Zouaghi, Salah Neghmouche Nacer, Lazhar Bechki, Touhami Lanez, Stefania Garzoli","doi":"10.1002/cbdv.71277","DOIUrl":"https://doi.org/10.1002/cbdv.71277","url":null,"abstract":"<p><p>Diabetes mellitus is a widespread metabolic disorder characterized by impaired glucose regulation. This study investigated the chemical composition and antidiabetic potential of Origanum majorana essential oil (EO) using integrated in vitro, in vivo, and computational approaches. GC-MS analysis identified 42 constituents representing 96.28% of the oil, with trans-thujone (33.30%), santolina triene (16.42%), and cis-verbenyl acetate (15.05%) as the dominant components. In vitro assays revealed strong inhibitory activity against carbohydrate-hydrolyzing enzymes, with IC₅₀ values of 3.68 µg/mL for α-amylase and 4.71 µg/mL for α-glucosidase, which were lower than those of the reference drug acarbose (11.17 and 9.68 µg/mL, respectively). In vivo evaluation in alloxan-induced diabetic rats demonstrated a significant reduction in fasting blood glucose levels from 1.47 ± 0.04 g/L in the diabetic group to 0.94 ± 0.03 g/L after EO treatment, accompanied by improvements in biochemical and histopathological parameters. Molecular docking identified several major EO constituents with strong binding affinities toward α-amylase and α-glucosidase, particularly cis-verbenyl acetate (-6.64 and -7.27 kcal/mol) and β-pinene oxide (-5.40 and -6.46 kcal/mol), exceeding the affinity of acarbose. ADMET analysis predicted favorable pharmacokinetic profiles and low toxicity risks for these compounds. Molecular dynamics simulations confirmed stable protein-ligand interactions, while MM-PBSA calculations supported strong binding free energies. Density functional theory (DFT) analysis further revealed moderate reactivity and enhanced stability in aqueous environments. Overall, the combined experimental and computational findings suggest that O. majorana EO, particularly its constituents cis-verbenyl acetate and β-pinene oxide, represents a promising natural source of antidiabetic agents warranting further pharmacological investigation.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 5","pages":"e71277"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depigmenting Effects of Vitex rotundifolia Cone Essential Oil in Melanocytes and Its Chemical Composition.","authors":"Da Yeon Yoo, Kyung Jong Won, Yoon Yi Kim, Do Yoon Kim, Ji Hye Bae, Ji Seong Yun, Hwan Myung Lee","doi":"10.1002/cbdv.202503740","DOIUrl":"https://doi.org/10.1002/cbdv.202503740","url":null,"abstract":"<p><p>Vitex rotundifolia L.f. (VRL) is a plant belonging to the Verbenaceae family with antipyretic, analgesic, and anti-inflammatory properties, but research on the melanocyte-targeted skin depigmenting-related responses of VRL is lacking. In this study, VRL cone essential oil (VRLCEO) was obtained through steam distillation, and its effects on melanin synthesis and transport-related responses were investigated. Gas chromatography-mass spectrometry analysis identified 15 components from VRLCEO. In all biological activity experiments, VRLCEO was used at noncytotoxic concentrations (≤ 50 µg/mL) to ensure cell viability. VRLCEO inhibited serum-induced cell proliferation of B16BL6 mouse melanoma cells. VRLCEO suppressed tyrosinase enzyme activity and melanin synthesis in B16BL6 melanoma cells induced by α-MSH. VRLCEO also reduced the expression of MITF, tyrosinase, and TRP-2 proteins in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16BL6 cells, but did not affect TRP-1 protein expression. Moreover, it increased the p38 MAPK and ERK1/2 phosphorylation levels in α-MSH-exposed B16BL6 cells, but not the JNK phosphorylation level. Furthermore, VRLCEO decreased α-MSH-upregulated Rab27a and melanophilin expression in B16BL6 cells. Therefore, VRLCEO may exert an anti-pigmentation effect by inhibiting melanin production and transfer in melanocytes. Accordingly, VRLCEO may be a natural material for the development of skin whitening agents.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 5","pages":"e03740"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical and Nutritional Characterization of Porophyllum linaria: Novel Cyclopropane-Containing Waxes and Comparative Analysis With P. macrocephalum.","authors":"Sebastián Martínez-Flores, María Guadalupe Martínez-Villarreal, Fernando Domínguez-Martínez, Mariana Lozano-González, Isabel Rivero-Cruz, Laura Flores-Bocanegra, Paulina Del Valle-Pérez, Martha Macías-Rubalcava, Robert Bye, Edelmira Linares, Omar Emiliano Aparicio-Trejo, Rachel Mata","doi":"10.1002/cbdv.71245","DOIUrl":"https://doi.org/10.1002/cbdv.71245","url":null,"abstract":"<p><p>An integrative phytochemical investigation of Porophyllum linaria was conducted in comparison with Porophyllum macrocephalum, combining structural elucidation, volatilome profiling, analytical method development, bioactivity, and nutritional assessment. Chromatographic fractionation of a MeOH-CH₂Cl₂ (1:1) extract of P. linaria afforded two undescribed long-chain cyclopropyl alcohol waxes, identified as cis-8,9-methylenuntriacontan-5-ol and cis-7,8-methylenuntriacontan-5-ol, whose structures were established by extensive spectroscopic analysis (1D and 2D NMR, HRESIMS) and chemical derivatization. Volatile constituents of both species were characterized, revealing interspecific differences. P. linaria essential oil was dominated by β-myrcene, d-limonene, nonanal, decanal, and (E)-2-dodecenal, whereas P. macrocephalum showed a limonene-rich profile with lower aldehyde content. LC-ESI-MS analysis of infusion extracts demonstrated distinct flavonoid patterns, with avicularin as the major marker of P. linaria and quercetin derivatives predominant in P. macrocephalum. Two validated UHPLC-MS methods were developed for the quantification of avicularin and quercetin in the respective species. Aqueous extracts exhibited antihyperglycemic and radical-scavenging activities. Nutrient analysis revealed their high fiber and mineral content. This study expands the chemical diversity of the genus Porophyllum, reports new cyclopropane-derived wax constituents, and provides analytical markers to support species differentiation and quality control. Chemical diversity of plant wax constituents contributes novel structural motifs to the genus Porophyllum.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 5","pages":"e71245"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Coumarins Galbanic Acid and Auraptene Improved the Efficacy of Alkeran on Human Osteosarcoma Cells by Targeting ABC Transporters.","authors":"Parastoo Azadbeigi, Sara Seyedshazileh, Ahmadreza Gharaiean-Morshed, Mehrdad Iranshahi, Fatemeh B Rassouli","doi":"10.1002/cbdv.202502926","DOIUrl":"https://doi.org/10.1002/cbdv.202502926","url":null,"abstract":"<p><p>Osteosarcoma is a severe bone malignancy, and current chemotherapeutic strategies often struggle to effectively halt disease progression. Galbanic acid (GBA) and auraptene (AUR) are natural sesquiterpene coumarins known for their diverse pharmacological activities. This study is the first to evaluate the ability of GBA and AUR to enhance Alkeran-induced toxicity in osteosarcoma cells. GBA and AUR were isolated from Ferula szowitsiana, and the viability and apoptosis of osteosarcoma cells were assessed following treatments with GBA, AUR, and Alkeran-alone and in combination. An efflux assay was conducted to determine the functional interactions of AUR and GBA with ABC transporters, and molecular docking and dynamics simulations were performed to explore their potential interactions. Single treatment of cells with each agent did not induce significant toxicity: however, combination treatments of GBA or AUR with Alkeran significantly (p < 0.0001) reduced cell viability. Synergistic interaction was strong for both coumarins and Alkeran, supported by flow cytometry detection of apoptosis and ABC transporter activity. Molecular docking and dynamics simulations demonstrated favorable and stable interactions of coumarins with ABC transporters. In conclusion, this study provides strong support that GBA and AUR enhanced Alkeran efficacy in osteosarcoma cells by targeting ABC transporters.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 5","pages":"e02926"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Talaroindiones A-C, New Polyketides Characterized From the Cold-Seep-Derived Talaromyces indigoticus CS-469.","authors":"Ruo-Xi Deng, Xiao-Ming Li, Bin-Gui Wang, Ling-Hong Meng","doi":"10.1002/cbdv.71316","DOIUrl":"https://doi.org/10.1002/cbdv.71316","url":null,"abstract":"<p><p>Three novel polyketides, talaroindiones A-C (1-3), along with two known diphenyl ether derivatives (4 and 5) were isolated from the rice culture medium extract of the marine-derived fungus Talaromyces indigoticus CS-469. The structures of 1-3 were determined by comprehensive spectroscopic analysis and confirmed by single-crystal x-ray diffraction. Their absolute configurations were assigned using TDDFT-ECD calculations, while those of 4 and 5 were established by comparison of their experimental optical rotations with literature values. All compounds were evaluated for their antibacterial activity. Compound 4 exhibited broad-spectrum inhibitory activities against six bacterial strains, showing particularly potent activity against Vibrio harveyi and Vibrio parahaemolyticus with MIC values of 2 µg/mL.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 5","pages":"e71316"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}