Chemistry & Biodiversity最新文献

{"title":"Three Previously Undescribed Compounds Isolated From the Leaves of Syzygium antisepticum With Their α-Glucosidase and Nitric Oxide Inhibitory Activity.","authors":"Do Thi Trang, Nguyen Viet Dung, Ngo Anh Bang, Vu Kim Thu, Le Thi Thuy Hang, Pham Hai Yen, Bui Huu Tai, Phan Van Kiem","doi":"10.1002/cbdv.202501820","DOIUrl":"https://doi.org/10.1002/cbdv.202501820","url":null,"abstract":"<p><p>Three previously undescribed compounds, 2α,3β,20α,23-tetrahydroxy-nor-30-urs-12-en-28-oic acid 28-O-β-d-glucopyranoside (1), 2α,3β,6β,23-tetrahydroxyoleana-11,13(18)-dien-28-oic acid (2), and 4,6-dihydroxy-3-methyl-2-O-β-d-glucopyranosylbenzophenone (3), together with 11 known compounds (4-14) are isolated from the leaves of Syzygium antisepticum. The isolated compounds are characterized via HR-ESI-MS and NMR spectra. Compounds 1, 2, 6, and 7 exhibited significant inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells with IC₅₀ values of 16.3, 14.9, 25.5, and 24.7 µM, respectively. In addition, compounds 9-12 displayed the most potential α-glucosidase with IC₅₀ values ranging from 23.6 to 162.0 µM.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01820"},"PeriodicalIF":2.5,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Tyrosine Kinase Inhibitors as Antineoplastic Agents in Pharmaceutical and Biological Matrices: An Overview of Recent Analytical Techniques.","authors":"Edoh Nicodème Gabiam, Nevin Erk, Wiem Bouali, Asena Ayşe Genç","doi":"10.1002/cbdv.202501025","DOIUrl":"https://doi.org/10.1002/cbdv.202501025","url":null,"abstract":"<p><p>Tyrosine kinase inhibitors (TKIs), widely used in cancer therapy, comprise diverse classes of therapeutic agents such as alkylating agents, antimetabolites, mitotic inhibitors, and targeted therapies. Due to their therapeutic significance and toxic effects, accurate determination of these drugs in pharmaceutical formulations, biological fluids, and environmental matrices is crucial. However, challenges arise from their complex structures and matrix interferences. This review highlights recent advancements in analytical techniques for TKIs, focusing on liquid chromatography, gas chromatography, capillary electrophoresis, spectroscopic methods, and electrochemical methods employed over the last decade. Innovations in sample preparation, including solid-phase extraction and molecularly imprinted polymers, have led to improved sensitivity and selectivity. Advanced detection systems like mass spectrometry, electrochemical sensors, and fluorescence techniques are emphasized for trace-level analysis and real-time monitoring. Key challenges, including green method development, matrix effect minimization, and method robustness, are discussed. To overcome these challenges, future directions should include the use of nanomaterials, microfluidic devices, and machine learning to enhance analytical efficiency. This review provides insights into emerging strategies for precise TKIs, supporting therapeutic monitoring, environmental safety, and analytical advancements.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01025"},"PeriodicalIF":2.5,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemicals From Hansenia weberbaueriana for Psoriasis and Inflammatory Bowel Disease Comorbidity: Based on Network Pharmacology and In Vitro Analysis.","authors":"Yuhong Tian, Xiujin Xu, Yujie Chen, Nabeel Khalid Bhutta, Xiaoming Chen, Bingnan Han","doi":"10.1002/cbdv.202502476","DOIUrl":"https://doi.org/10.1002/cbdv.202502476","url":null,"abstract":"<p><p>Comorbidities, associated with higher rates of disability and mortality, have emerged as a global focus and a significant challenge. Psoriasis (PSO) and inflammatory bowel disease (IBD) are autoimmune disorders with frequent comorbidity and shared inflammatory pathways, yet targeted therapies remain limited. Utilizing an integrated approach combining network pharmacology, bioinformatics, machine learning, molecular docking, and in vitro experiments, we investigated Hansenia weberbaueriana (HW) for its potential to treat the comorbidity of PSO and IBD. Bioinformatics analysis identified 38 intersecting genes between PSO-IBD comorbidity and HW, predominantly enriched in the advanced glycation end-product (AGE)-receptor for AGE (RAGE) signaling pathway. Combining machine learning, weighted gene co-expression network analysis, and molecular docking prioritized PTGS2 (Cyclooxygenase 2 [COX2]) as the top target, with Cnidilin (HW8), a bioactive coumarin derivative from HW, exhibiting high-affinity binding (binding energy: -6.418 kcal/mol and molecular mechanics-generalized born surface area: -35.43 kcal/mol). Furthermore, 100-ns molecular dynamics (MD) simulations confirmed stable Cnidilin-PTGS2 interactions (root mean square deviation ∼2.3 Å). In vitro analysis demonstrated that Cnidilin (10 µM) significantly suppressed COX2, tumor necrosis factor-alpha, and nitric oxide in RAW 264.7 cells, supporting its multi-target mechanism. This study provided the first evidence supporting the therapeutic role of HW in PSO-IBD comorbidity via COX2 suppression and established a machine learning-driven framework for identifying natural compounds with dual therapeutic potential.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02476"},"PeriodicalIF":2.5,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Workflow for Selecting, Profiling, and Optimizing Plant Extracts for Cosmetic Applications.","authors":"Maria Viéytez, Aline Robert-Hazotte, Amélie Thomas, Véronique Nardello-Rataj, Xavier Fernandez","doi":"10.1002/cbdv.202502397","DOIUrl":"https://doi.org/10.1002/cbdv.202502397","url":null,"abstract":"<p><p>In response to the growing demand for innovative natural ingredients in cosmetics, this study proposes a structured approach to identifying bioactive plant species available in France. From 1614 species screened for regulatory acceptability and innovation potential, 18 were shortlisted for phytochemical profiling (high-performance liquid chromatography [HPLC]-diode array detector [DAD]/evaporative light scattering detector [ELSD]) and in vitro antioxidant and enzymatic assays. A dual scoring system combining bioactivity and novelty metrics highlighted four promising species for cosmetic development. To explore how cultivation methods can optimize ingredient performance, Borago officinalis L., a fifth species with moderate initial scores, was selected for a case study based on its agronomic feasibility, identified with an industrial partner. Cultivated indoors under controlled conditions using a rotational geoponics system, borage showed improved antioxidant properties under low-temperature conditions. These findings provide a replicable workflow for sourcing plant-based natural active ingredients and illustrate how tailored cultivation can unlock the potential of well-known but underexploited species.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02397"},"PeriodicalIF":2.5,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green-Synthesized Metal Nanoparticles Coated With Chitosan: Enhanced Stability and Antimicrobial Potential Against ESKAPE Pathogens.","authors":"Susrita Sharma, Anindya Bose, Prafful P Kothari, Sri Ganga Padaga, Swati Biswas","doi":"10.1002/cbdv.202501885","DOIUrl":"https://doi.org/10.1002/cbdv.202501885","url":null,"abstract":"<p><p>The global challenge of multidrug resistance and the rapid spread of ESKAPE bacteria necessitate the urgent development of safe and effective antimicrobial agents. Metal nanoparticles (MNPs) offer promise due to their unique properties but are hindered by challenges, such as agglomeration, which reduces their stability and efficacy. Surface coating with chitosan is a promising solution that synergistically enhances stability and antimicrobial activity. This study explored the green synthesis of silver (Ag), gold (Au), zinc oxide (ZnO), and copper (Cu) nanoparticles using Cyperus rotundus extract, followed by surface coating with chitosan, to assess improvements in stability and antimicrobial activity against two representative ESKAPE bacteria-Pseudomonas aeruginosa and Staphylococcus aureus. The results varied, with chitosan affecting the agglomeration and stability of each metal differently. Although agglomeration significantly influenced stability, it did not strongly affect antimicrobial activity. This study highlights that preventing agglomeration is crucial for ensuring the stability of MNPs, and chitosan coating plays a critical role in preventing agglomeration and enhancing nanoparticle stability without necessarily dictating antimicrobial efficacy. Importantly, CH@AgNPs show significant potential as an alternative to antibiotics against multidrug-resistant ESKAPE pathogens, supporting their further development for pharmaceutical applications.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01885"},"PeriodicalIF":2.5,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioid and Nitrergic Pathways Mediate Antinociception by Pectis elongata Kunth. Essential Oil.","authors":"Angela Palma Amorin, Sandra Layse Ferreira Sarrazin, Leomara Andrade da Silva, Thaiana Neves Coelho, Adriele Pantoja Cunha, Vitória Albuquerque de Lima, Domingas Machado da Silva, Pablo Luis Baia Figueiredo, Ricardo Bezerra de Oliveira","doi":"10.1002/cbdv.202501962","DOIUrl":"https://doi.org/10.1002/cbdv.202501962","url":null,"abstract":"<p><p>In the present study, we aimed to evaluate the antinociceptive potential of the Pectis elongata essential oil (PeEO) and to understand its mechanism of action by identifying possible pain inhibition pathways. PeEO was analyzed using gas chromatography coupled with mass spectrometry. Male Swiss mice were subjected to the hot plate test to assess analgesic activity, determine the effective dose, and elucidate the pharmacological pathways involved, using specific blockers of the opioid, cholinergic, and nitric oxide pathways. Chemical analysis identified 23 compounds accounting for 95.57% of the sample, with citral (86.4%-Geranial and Neral) as the major constituent. The antinociceptive activity of PeEO was observed at a dose of 600 mg/kg, and this effect was mediated by the opioid and nitrergic pathways, as evidenced by pretreatment with L-NAME and naloxone. These findings reinforce the analgesic potential of PeEO, possibly related to its high citral content.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01962"},"PeriodicalIF":2.5,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Inflammatory, Antioxidant, Molecular Docking and Pharmacokinetics Properties of Cycloeucalenone Isolated From Musa × paradisiaca L. Fruit Peels.","authors":"Ibeabuchi J Ali, Kolawole A Olofinsan, Goodnews O Ikeh, Ndidiamaka H Okorie, Cyril C Adonu, Romanus C Omeh, Blessing C Idoko, Pamela E Nnamani","doi":"10.1002/cbdv.202502342","DOIUrl":"https://doi.org/10.1002/cbdv.202502342","url":null,"abstract":"<p><p>This study isolated a compound with anti-inflammatory properties from Musa × paradisiaca fruit peels. The methanol extract was partitioned, and the hexane fraction with the best bioactivity was subjected to column chromatography before characterization via Fourier transform infrared (FTIR), UV-visible (UV-VIS) and NMR analysis. The in vivo anti-inflammatory properties of the methanol extract and hexane fraction were investigated using the formalin-induced oedema model in rats. The compound's antioxidant, red blood cell (RBC) membrane stabilization and phospholipase-A2 (PL-A2) inhibitory effects were evaluated in vitro. The UV-VIS spectrum at 222 nm absorbance and FTIR absorption at 2922, 2855, 1707, 1643, 1453 and 1375 cm^-1 with proton and carbon-13 spectra suggest the compound is a steroid. The in vivo anti-inflammatory assay showed significant oedema reduction of the hexane fraction at 200 mg/kg. The compound also displayed Fe³⁺ reduction and scavenged free radical molecules while showing PL-A2 inhibition and the ability to limit RBC haemolysis. The compound also presented stronger affinities for PL-A2 (-7.6 kcal/mol) and NF-κB (-6.0 kcal/mol) than indomethacin and ibuprofen drugs, with a favourable pharmacokinetic model. Though M. × paradisiaca fruit peels are often discarded as waste, our study highlights a sustainable approach to the reutilization of this plant material as a source of a lead molecule for inflammatory disease management.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02342"},"PeriodicalIF":2.5,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytofabrication of Zinc Oxide Nanoparticle for Wound Management: Insights From In Vitro, In Vivo, and In Silico Studies.","authors":"Munaza Khan, Zainab Maqbool, Arusa Aftab, Zubaida Yousaf, Awais Khalid, Aneela Zameer Durrani","doi":"10.1002/cbdv.202501742","DOIUrl":"https://doi.org/10.1002/cbdv.202501742","url":null,"abstract":"<p><p>Various diseases emerge from inflammation, which are indicated by pain, swelling, and redness. The conventional method to overcome inflammation is use of synthetic drugs, that is, diclofenac, ibuprofen, naproxen, and aspirin. These synthetic drugs not only reduce pain at that time but also cause drastic effects on the vital organs like the kidney, liver, and digestive tract. There is a serious need to develop herbal remedies because the world is returning into natural, safe, and organic medicines. The present study was proposed to attain sustainable development goal 3 (good health and well-being). Plant-mediated nanoparticles (NPs) offer regulated drug release, being sustainable, target-specific, small sized, and eco-friendly. Current study evaluated the in vivo and in vitro anti-inflammatory, antibacterial, and antioxidant properties of aqueous leaf extract of Solanum nigrum L. and Solanum americanum M. Biofabricated zinc oxide NPs and formulation of wound healing herbal bandage as well as in silico studies, were also performed. Their efficacy was also explored through in vitro anti-inflammatory activity (hemolysis assays and protein denaturation inhibition assay) and in vivo anti-inflammatory activity (wound healing in rabbits), including histopathological analysis. In vitro results depicted that S. nigrum aqueous leaf extract exhibited lowest % age of hemolysis (0.1 ± 0.0005) at 50 µL concentration, whereas S. americanum mediated ZnO NPs displayed highest % of hemolysis (0.08 ± 0.0055) at 100 µL concentration. In vivo results indicated that bandages coated with S. nigrum aqueous extract and S. americanum significantly improved wound healing. ZnO nanocoated bandage exhibited the paramount anti-inflammatory properties, suggesting it could be a viable alternative to conventional allopathic drugs. In silico results identified 112 inflammation-associated gene targets, whereas tumor necrosis factor (TNF), IL6, and AKT1 were identified as top hub genes. Gas chromatography-mass spectrometry (GC-MS) and network pharmacology analysis identified key phytochemicals like kaempferol and quercetin. These phytochemicals target TNF, IL6, and AKT1 for drug repurposing, particularly to manage inflammation.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01742"},"PeriodicalIF":2.5,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Biochanin A Carbamate Derivatives as Multifunctional Anti-Alzheimer's Disease Metal Chelators: Design, Synthesis, and Activity Evaluation.","authors":"Yiyi Sun, Xinjie Jiang, Xiaoyue Yi, Caiyun Wang, Xiangyu Zhang, Rui Shen, Aihong Yang, Xiaodi Kou","doi":"10.1002/cbdv.202501827","DOIUrl":"https://doi.org/10.1002/cbdv.202501827","url":null,"abstract":"<p><p>Considerable evidence suggests that metal ions play crucial roles in Alzheimer's disease (AD) progression, spurring the development of metal-involved therapeutic strategies. In this study, biochanin A, a bioactive ingredient derived fromTrifolium pratense L. (a traditional Chinese medicine [TCM]), was identified as a lead compound for the rational design of multifunctional metal chelators. A series of biochanin A derivatives (compounds a-e) was synthesized through a one-step carbamate introduction reaction. Their drug-likeness and pharmacokinetic profiles were assessed using an online prediction server. The bioactivities, including metal ion chelation, β-amyloid aggregation regulation, reactive oxygen species elimination, cholinesterase inhibition, and neurocytotoxicity were evaluated. The results indicated that compounds (a-e) possessed favorable pharmacokinetic profiles and potential as multifunctional metal chelators with minimal neurocytotoxicity, with compound d emerging as a particularly promising candidate. These findings may provide meaningful information for developing novel multifunctional metal chelators for AD treatment and innovative drugs derived from TCM.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01827"},"PeriodicalIF":2.5,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compositional Analysis of Cultivated and Wild-Harvested Boswellia sacra Frankincense Resin Essential Oils in Oman.","authors":"Anjanette DeCarlo, Stephen Johnson, Salah Agieb, Prabodh Satyal, Aaron Sorensen, William N Setzer","doi":"10.1002/cbdv.202502268","DOIUrl":"https://doi.org/10.1002/cbdv.202502268","url":null,"abstract":"<p><p>Frankincense is a valuable aromatic resin, used globally for its scent, therapeutic properties, and religious significance. All frankincense is currently harvested from wild Boswellia trees, but recent research has identified serious social and environmental challenges in wild supply chains, including significant population declines in multiple frankincense species. Cultivation of Boswellia trees in commercial plantations could be a possible solution to these challenges, but there have been widespread misgivings amongst harvesting communities and industry whether cultivated plants could produce essential oils of sufficient complexity to match existing wild-harvested stocks. We collected resin samples from both cultivated and wild individual frankincense trees in southern Oman, and compared them with wild harvesting-derived commercial frankincense essential oil samples. The cultivated tree samples were similar to existing wild-derived commercial samples, with no loss of phytochemical complexity. We also found a previously unreported δ-3-carene/α-pinene chemotype in the individual wild tree samples. The results indicate that plantation-produced frankincense could replicate current wild-harvested commercial batches, but that there is under-explored phytochemical diversity in the species, which necessitates caution in plantation stock selection. In addition, movement from wild harvesting to cultivation can have mixed social and conservation impacts, especially for a product with the cultural and livelihood significance of frankincense. Care must therefore be taken to ensure that potential positive impacts are realized, and potential negative impacts are fully mitigated.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02268"},"PeriodicalIF":2.5,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}