Chemistry & Biodiversity最新文献

Comprehensive UHPLC-MS/MS and GC-MS Metabolite Profiling and Anti-Inflammatory Effect of the Ethanol Extract and Essential Oil of Cymbopogon citratus (DC.) Staph Grown in Aceh, Indonesia. 枸杞醇提物和精油的UHPLC-MS/MS和GC-MS综合代谢物分析及抗炎作用葡萄球菌生长在印度尼西亚的亚齐。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-20 DOI: 10.1002/cbdv.202500668

Irma Sari, Mustanir Yahya, Ibrahim Jantan, Binawati Ginting, Elfahmi, Marissa Angelina, Hilda Maysarah

{"title":"Comprehensive UHPLC-MS/MS and GC-MS Metabolite Profiling and Anti-Inflammatory Effect of the Ethanol Extract and Essential Oil of Cymbopogon citratus (DC.) Staph Grown in Aceh, Indonesia.","authors":"Irma Sari, Mustanir Yahya, Ibrahim Jantan, Binawati Ginting, Elfahmi, Marissa Angelina, Hilda Maysarah","doi":"10.1002/cbdv.202500668","DOIUrl":"https://doi.org/10.1002/cbdv.202500668","url":null,"abstract":"In this study, a comprehensive chemical profiling of Cymbopogon citratus metabolites grown in Aceh, Indonesia, was performed by UHPLC-ESI-QTOF-MS/MS on its 80% ethanol extract, and GC-MS on its hydrodistilled essential oil. The samples were also investigated for their anti-inflammatory activity through bovine serum albumin (BSA) protein denaturation inhibition and human red blood cell (HRBC) membrane stabilization techniques. LC-MS/MS analysis of the extract putatively identified 54 compounds, represented by 23 phenolic compounds (flavonoids, flavonoid glycosides, lignans, anthraquinone glycosides, coumarins, and a phenolic acid), 7 carboxylic acids and esters, 7 carbohydrates, 5 amino acids, 5 lipids, 2 steroids, 2 lactones, 2 alkaloids, and 1 monoterpenoid. GC-MS analysis of the essential oil indicated it was mainly made up of monoterpenoids with neral (25.89%) and geranial (49.97%) as the major compounds. The chemical contents identified in the extract and essential oil of the plant grown in Aceh were qualitatively and quantitatively different from samples reported elsewhere. Both extract and essential oil exhibited anti-inflammatory activity by stabilizing the HRBC membrane against hypotonicity-induced hemolysis and inhibited the BSA protein denaturation in a concentration-dependent manner. The anti-inflammatory activity of C. citratus was attributed mainly to the presence of bioactive compounds especially phenolic compounds and monoterpenoids.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00668"},"PeriodicalIF":2.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Bioactive Components of Stevia Essential Oil and Their Versatile Applications in the Food, Cosmetic, and Agricultural Domains. 甜菊叶精油的生物活性成分及其在食品、化妆品和农业领域的广泛应用。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-20 DOI: 10.1002/cbdv.202500562

Pooja Sharma, Dharmender Sharma, Ritu Pawan, Denise Fernandes Coutinho, Randolph Arroo, Sonia Malik

{"title":"Exploring the Bioactive Components of Stevia Essential Oil and Their Versatile Applications in the Food, Cosmetic, and Agricultural Domains.","authors":"Pooja Sharma, Dharmender Sharma, Ritu Pawan, Denise Fernandes Coutinho, Randolph Arroo, Sonia Malik","doi":"10.1002/cbdv.202500562","DOIUrl":"https://doi.org/10.1002/cbdv.202500562","url":null,"abstract":"Essential oils have become popularized in various sectors due to their numerous beneficial effects. The global prominence of essential oils is attributed to the synergistic impact of their bioactive constituents. To meet the ever rising demand, industries are looking for the new renewable and natural sources of essential oils or their components. Stevia, primarily known as a natural sweetener, also contains essential oils that possess various biological properties. Different parts of Stevia plant possess essential oils and their components vary depending on the extraction method and physical or geographical conditions. The volatile oil obtained from Stevia contains several active components including aromatics, aldehydes, monoterpenes, and sesquiterpenes with antioxidant and antimicrobial activities, which are important in food preservation. The constituents of Stevia essential oil hold promising potential for application in the agricultural sector as anti-plasmodia, aphicidal, and insecticidal agents. In addition, their anti-inflammatory, antiaging, and skin-brightening effects make them valuable for use in cosmetic formulations. Evaluating the safety assessment of various components of Stevia essential oil is critical to support its potential use in various industries, highlighting its broad spectrum of applications.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00562"},"PeriodicalIF":2.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Bis-sesquiterpenoids From the Lindera glauca With Anti-inflammatory Activity by Inhibiting the Lipopolysaccharide-induced Expression of Inducible Nitric Oxide Synthase. 从青光眼中提取的新型双倍半萜类化合物，通过抑制脂多糖诱导的诱导型一氧化氮合酶的表达而具有抗炎活性。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-20 DOI: 10.1002/cbdv.202501246

Binglin Chang, Zelin Chen, Jingnan Li, Yingming Luo, Jingxin He, Yena Liu, Hui Cui

引用次数: 0

Ultrasound-Assisted Synthesis of Novel Chromone-Based Thiosemicarbazone Derivatives as Potential Anticancer Agents and Their Apoptotic, Cell Cycle, Autophagy, Molecular Docking, and ADMET Prediction Studies. 超声辅助合成新型铬基硫代氨基脲类抗癌药物及其凋亡、细胞周期、自噬、分子对接和ADMET预测研究

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-19 DOI: 10.1002/cbdv.202501342

Wafa A Bawazir, Tarik E Ali, Mohammed A Assiri, Ali A Shati, Mohammad Y Alfaifi, Serag E I Elbehairi, Hatoon S Alamri

{"title":"Ultrasound-Assisted Synthesis of Novel Chromone-Based Thiosemicarbazone Derivatives as Potential Anticancer Agents and Their Apoptotic, Cell Cycle, Autophagy, Molecular Docking, and ADMET Prediction Studies.","authors":"Wafa A Bawazir, Tarik E Ali, Mohammed A Assiri, Ali A Shati, Mohammad Y Alfaifi, Serag E I Elbehairi, Hatoon S Alamri","doi":"10.1002/cbdv.202501342","DOIUrl":"https://doi.org/10.1002/cbdv.202501342","url":null,"abstract":"A series of novel chromone derivatives bearing a thiosemicarbazone moiety (3a-i and 5) at the C-3 position was efficiently synthesized using ultrasound irradiation. The compounds were evaluated for in vitro cytotoxicity against T24 (bladder transitional cell carcinoma) and PC3 (human prostate adenocarcinoma) cell lines. Compounds 3b (R ═ Me) and 3g (R ═ benzyl) exhibited the most potent cytotoxicity, outperforming doxorubicin. These two compounds significantly induced late apoptosis and necrosis, arrested the cell cycle at distinct phases in both cell lines, and demonstrated potential for autophagic induction. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) predictions for them indicated favorable drug-like properties for these compounds, supporting their potential as anticancer agents. Molecular docking studies for both 3b and 3g revealed strong interactions with VEGFR-2 receptor, further highlighting their promise as scaffolds for novel antitumor drug development.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01342"},"PeriodicalIF":2.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Synthesis and Self-Healing Properties of Zwitterionic Hydrogels: Recent Trends and Applications. 两性离子水凝胶的合成及自愈性能研究：最新进展及应用。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-18 DOI: 10.1002/cbdv.202403431

Hany F Nour, Zarah Alqarni, Yasser M A Mohamed

{"title":"Exploring the Synthesis and Self-Healing Properties of Zwitterionic Hydrogels: Recent Trends and Applications.","authors":"Hany F Nour, Zarah Alqarni, Yasser M A Mohamed","doi":"10.1002/cbdv.202403431","DOIUrl":"https://doi.org/10.1002/cbdv.202403431","url":null,"abstract":"Self-healing zwitterionic hydrogels (ZIHs) have sparked widespread attention because of their intriguing properties and potential applications. One of the key features of ZIHs is their inherent antifouling properties, making them appealing for various biomedical applications. A notable characteristic of ZIHs is their self-healing capability, enabling them to mend damage and restore their mechanical properties, hence prolonging their lifespans and enhancing their functionality. Self-healing ZIHs exhibit excellent properties as wound-dressing materials by creating a moist environment that promotes the healing process. In addition to their antifouling, self-healing, wound-healing, and wound-dressing applications, zwitterionic self-healing hydrogels have shown promise in cardiac tissue engineering and cell encapsulation. In cell encapsulation, ZIHs provide promising platforms for the encapsulation and delivery of numerous cell types, including stem cells and therapeutic cells, as well as enable controlled release and protection during transplantation. The self-healing feature of ZIHs provides long-term stability and durability of these materials. This review focuses on state-of-the-art advancements in the synthesis strategies, self-healing mechanisms, and applications of ZIHs, offering an integrated perspective not previously addressed in the literature.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e03431"},"PeriodicalIF":2.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New α-Pyrones From Endophytic Fusarium Sp. L46 Isolated From Dioscorea opposita. 薯蓣内生镰刀菌L46新α-吡啶酮的分离纯化

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-18 DOI: 10.1002/cbdv.202500223

Ruo-Dan Tian, Ying-Fei Zhao, Fei-Fan Wang, Song-Jie Zhan, Chun-Nan Wen, Miao Liu, Bing-Ji Ma

引用次数: 0

Antibiotic Resistance: Revisiting Older Antibiotics for Modern Bacterial Challenges. 抗生素耐药性：重新审视现代细菌挑战的旧抗生素。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202400813

Alberto Boretti, Bimal Banik

{"title":"Antibiotic Resistance: Revisiting Older Antibiotics for Modern Bacterial Challenges.","authors":"Alberto Boretti, Bimal Banik","doi":"10.1002/cbdv.202400813","DOIUrl":"https://doi.org/10.1002/cbdv.202400813","url":null,"abstract":"The growing challenge of antibiotic resistance necessitates a strategic re-evaluation of older antibiotics as vital antimicrobial tools. This re-assessment, while facing hurdles, reveals promising possibilities. Understanding bacterial resistance mechanisms is fundamental for effectively utilizing these legacy drugs. Older antibiotics typically have a narrower spectrum than modern ones, emphasizing careful antimicrobial stewardship to prevent overuse and further resistance. Strategies to improve their clinical value include combination therapies with newer antibiotics to overcome resistance and boost efficacy. Furthermore, repurposing and reformulating older antibiotics can enhance their activity against contemporary bacterial strains. Targeted treatment regimens focusing on specific clinical niches or bacterial species where older antibiotics remain effective, are crucial. Streptothricin F exemplifies this renewed potential, particularly against Gram-negative bacteria, a recent research focus. Despite prior concerns about its limited spectrum and resistance potential, recent findings indicate streptothricin F's re-emerging utility. This antibiotic's ability to target highly resistant Gram-negative pathogens, such as carbapenem-resistant Enterobacterales, highlights its potential as a valuable therapeutic option. This encouraging discovery underscores the need for further research into streptothricin F's role in combating drug-resistant Gram-negative pathogens, opening avenues for future investigation.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00813"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant and Anti-Acetylcholinesterase Activities of Three Lippia L. Species: A Chemometric Approach. 三种Lippia的抗氧化和抗乙酰胆碱酯酶活性：化学计量学方法

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202500914

Carla de Fatima Alves Nonato, Emerson Vinicius Silva de Melo, Cicera Janaine Camilo, Débora Odília Duarte Leite, Irwin Rose Alencar de Menezes, Daniela Ribeiro Alves, Selene Maia de Morais, José Galberto Martins da Costa

{"title":"Antioxidant and Anti-Acetylcholinesterase Activities of Three Lippia L. Species: A Chemometric Approach.","authors":"Carla de Fatima Alves Nonato, Emerson Vinicius Silva de Melo, Cicera Janaine Camilo, Débora Odília Duarte Leite, Irwin Rose Alencar de Menezes, Daniela Ribeiro Alves, Selene Maia de Morais, José Galberto Martins da Costa","doi":"10.1002/cbdv.202500914","DOIUrl":"https://doi.org/10.1002/cbdv.202500914","url":null,"abstract":"The aim of this study was to compare the antioxidant and anti-acetylcholinesterase (anti-AChE) activities of certain species from the Lippia genus, relating them to previously identified metabolites by chemometric calculations. The antioxidant potentials were determined by DPPH, ABTS, deoxyribose protection, β-carotene, iron chelation, and reduction. The AChE inhibition activity was also evaluated. The data were related through multivariate analyses. All extracts showed significant antioxidant activity, especially Lippia gracilis, with an IC50 of 0.59 ± 0.08 µg/mL for Fe2+ chelation and also demonstrated the best AChE inhibition. Multivariate analyses proved the effectiveness of Lippia sidoides constituents in Fe2+ chelation, DPPH radical reduction, deoxyribose protection, and anti-AChE. It is concluded that the results demonstrate important activities of the extracts, and further studies are needed to confirm the correlations between Lippia secondary metabolites and their use in food preservation.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00914"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Phenoxy Substituted Imidazo[1,2-b]Pyridazine-Based Amide Derivatives for Antibacterial and Anti-Tubercular Activities. 苯氧基取代咪唑[1,2-b]吡啶嗪类酰胺衍生物的合成及其抗菌和抗结核活性。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202500474

Neelam Yesubabu, Dharmarajan Sriram, Boddu Rama Krishna, Jyothi Prashanth, Koya Prabhakara Rao

{"title":"Synthesis of Phenoxy Substituted Imidazo[1,2-b]Pyridazine-Based Amide Derivatives for Antibacterial and Anti-Tubercular Activities.","authors":"Neelam Yesubabu, Dharmarajan Sriram, Boddu Rama Krishna, Jyothi Prashanth, Koya Prabhakara Rao","doi":"10.1002/cbdv.202500474","DOIUrl":"https://doi.org/10.1002/cbdv.202500474","url":null,"abstract":"A series of 10 phenoxy-substituted imidazo[1,2-b]pyridazine amide derivatives were synthesized from 6-chloro-2-methyl-8-phenoxyimidazo[1,2-b]pyridazine-3-carboxylic acid and respective amines. All these 10 compounds were characterized using spectroscopic analysis (1H, 13C, HPLC, and ESI). Furthermore, the molecular structure obtained with spectroscopic analysis was confirmed by single-crystal x-ray diffraction (SXRD) analysis with a compound 12. All the 10 newly synthesized compounds were screened for in vitro antibacterial activities with the agar dilution method against two Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). Compounds 11 and 13 both showed MIC values, 6.25 µg/mL, and comparable antibacterial activity to the positive control with the reference drug. Similarly, Mycobacterium tuberculosis H37Rv using the Microplate Alamar Blue Assay (MABA) and compounds 9 and 12 displayed moderate tubercular activities at a concentration of 25 µg/mL. The molecular docking studies correlated with biological activity against the active sites of PDB ID: 5JZX.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00474"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, and Anticancer Evaluation of Novel 6-Alkynylated Harmine Derivatives. 新型6-炔基化鼠胺衍生物的设计、合成及抗癌评价。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202500130

Dongyan Hu, Guangtian Han, Sha Yu, Huazhong Ren, Xi'an Li, Jiao Xu, Jiafu Feng, Dong Yi

{"title":"Design, Synthesis, and Anticancer Evaluation of Novel 6-Alkynylated Harmine Derivatives.","authors":"Dongyan Hu, Guangtian Han, Sha Yu, Huazhong Ren, Xi'an Li, Jiao Xu, Jiafu Feng, Dong Yi","doi":"10.1002/cbdv.202500130","DOIUrl":"https://doi.org/10.1002/cbdv.202500130","url":null,"abstract":"In order to explore the effect of alkynyl introduction at the 6-position of harmine on the antitumor activity, 23 novel 6-alkynylated harmine derivatives (3a-3w) were synthesized and investigated for their anti-proliferative activity on a panel of cancer cell lines. Compound 3u demonstrated the most potent anti-proliferative activity, with IC50 = 0.77 µM against MDA-MB-231 cell lines. Further mechanistic investigations revealed that compound 3u could induce apoptosis in a concentration-dependent manner and arrest the cell cycle in the G2/M phase in MDA-MB-231 cells. In addition, compound 3u significantly suppressed cell migration in the wound healing assay and reduced the mitochondrial membrane potential of MDA-MB-231 cell lines. Furthermore, molecular docking studies revealed that compound 3u exhibited strong binding affinity to the active site of EGFR through hydrogen bonding and hydrophobic interaction. Moreover, the cytotoxic study of compound 3u on the BEAS-2B, a normal human lung epithelial cell line, further highlights the potential of compound 3u molecule as an anticancer agent for breast cancer with a selectivity index of 45.70.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00130"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0