Chemistry & Biodiversity最新文献

Three New Phenyl Ether Derivatives From the Deep-Sea-Derived Fungus Aspergillus sp. SCSIO 41230. 深海真菌曲霉sp.三种新的苯醚衍生物。SCSIO 41230。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-09-30 DOI: 10.1002/cbdv.202502248

Yanchun He, Shuna Xu, Juan Gao, Juan Liu, Xuefeng Zhou, Yonghong Liu, Xiaoyong Zhang, Bin Yang

引用次数: 0

Comparative Study of Antidiabetic and Antioxidant Properties of Viburnum opulus L. and Viburnum lantana L. (Viburnaceae): LC-MS/MS Profiling of Phenolic Compounds. 桃荚苋和蓝荚苋抗糖尿病和抗氧化性能的比较研究：酚类化合物的LC-MS/MS谱分析。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-09-30 DOI: 10.1002/cbdv.202501794

Zahra Effatparvar, Bilge Aydın, Hafize Yuca, Mehmet Önal, Gökhan Zengin, Ayşe Çiçek Kaya, Songül Karakaya, Agnese Santanatoglia, Ahmed Mustafa, Giovanni Caprioli, Zühal Güvenalp

{"title":"Comparative Study of Antidiabetic and Antioxidant Properties of Viburnum opulus L. and Viburnum lantana L. (Viburnaceae): LC-MS/MS Profiling of Phenolic Compounds.","authors":"Zahra Effatparvar, Bilge Aydın, Hafize Yuca, Mehmet Önal, Gökhan Zengin, Ayşe Çiçek Kaya, Songül Karakaya, Agnese Santanatoglia, Ahmed Mustafa, Giovanni Caprioli, Zühal Güvenalp","doi":"10.1002/cbdv.202501794","DOIUrl":"https://doi.org/10.1002/cbdv.202501794","url":null,"abstract":"This study aimed to evaluate antidiabetic and antioxidant properties of Viburnum opulus and Viburnum lantana aerial parts methanolic extracts, alongside identification of their bioactive constituents using LC-MS/MS analysis. LC-MS/MS analysis revealed that V. lantana leaves had the highest total polyphenol content (78.955 µg/g dry extract), followed by V. opulus twigs (67.203 µg/g dry extract), with chlorogenic acid being the predominant compound in both species. Antidiabetic potential was assessed through inhibition of α-amylase and α-glucosidase enzymes, while antioxidant activity was determined via ABTS and DPPH radical scavenging assays. In the α-glucosidase inhibition assay, methanolic extracts from leaves, fine branches, and fruits of both species exhibited greater inhibitory activity than the positive control, acarbose, with the leaf extract of V. lantana displaying the strongest inhibition. Regarding antioxidant capacity, V. lantana leaf extracts demonstrated the highest efficacy, outperforming α-tocopherol and Trolox. Notably, in the ABTS radical scavenging assay, V. lantana leaf extracts exhibited superior inhibitory effects compared to α-tocopherol and Trolox.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01794"},"PeriodicalIF":2.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant, Antidiabetic, and Antiobesity Properties of Stachys cretica subsp. anatolica and Its LC-MS/MS Analysis: In Vitro and In Silico Studies. 石竹的抗氧化、抗糖尿病和抗肥胖特性。安纳托利卡及其LC-MS/MS分析：体外和计算机研究。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-09-30 DOI: 10.1002/cbdv.202502336

Semih Bulut, Ravzagül Toslak, Muhammed Tilahun Muhammed, Ahmet Kahraman, Mustafa Abdullah Yilmaz

{"title":"Antioxidant, Antidiabetic, and Antiobesity Properties of Stachys cretica subsp. anatolica and Its LC-MS/MS Analysis: In Vitro and In Silico Studies.","authors":"Semih Bulut, Ravzagül Toslak, Muhammed Tilahun Muhammed, Ahmet Kahraman, Mustafa Abdullah Yilmaz","doi":"10.1002/cbdv.202502336","DOIUrl":"https://doi.org/10.1002/cbdv.202502336","url":null,"abstract":"For many years, Stachys species have been traditionally used against various diseases. This study was carried out to analyze the chemical content of the aerial parts of Stachys cretica subsp. anatolica and to investigate its antioxidant, antidiabetic, and antiobesity effects. Moreover, it was aimed to carry out a molecular modeling study between the strongest activity shown by the extract and its main chemical component. Although the antidiabetic and antiobesity effects of the extract were evaluated by enzyme inhibition tests, its chemical content was analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). Molecular modeling studies based on the major component of the extract were investigated by molecular docking and molecular dynamics simulation methods. The extract had significant antioxidant activity and α-glucosidase inhibitory activity (IC50: 24.18 ± 1.44 µg/mL). The extract was found to be rich in quinic acid (55.708 mg/g extract). On the other hand, the computational study disclosed that the major phytocomponents could bind to the α-glucosidase structure and form a stable complex. In conclusion, this extract may be an important resource for pharmaceutical industries.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02336"},"PeriodicalIF":2.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Extraction Method on Physicochemical Properties, Fatty Acid Profile, and Tocol Content of Pistacia lentiscus Oil From the Hodna Subarid Region (Algeria). 提取方法对阿尔及利亚霍德纳半干旱区黄连木油理化性质、脂肪酸谱及油醇含量的影响

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-09-29 DOI: 10.1002/cbdv.202501018

Lamia Derradji, Abderrahim Benkhaled, Kıvılcım Yıldız, Zeynep Aksoylu Özbek, Ahmed Nouasri, Pelin Günç Ergönül

{"title":"Influence of Extraction Method on Physicochemical Properties, Fatty Acid Profile, and Tocol Content of Pistacia lentiscus Oil From the Hodna Subarid Region (Algeria).","authors":"Lamia Derradji, Abderrahim Benkhaled, Kıvılcım Yıldız, Zeynep Aksoylu Özbek, Ahmed Nouasri, Pelin Günç Ergönül","doi":"10.1002/cbdv.202501018","DOIUrl":"https://doi.org/10.1002/cbdv.202501018","url":null,"abstract":"The main objective of this study was to assess the influence of the subarid origin and extraction process (traditional hot and cold methods) on the physicochemical properties, fatty acid (FA) composition, and tocol profile of Pistacia lentiscus fruit oil from the Hodna region of Algeria. According to the physicochemical characteristics, differences were observed between oils obtained through cold pressing and hot extraction. The fruit of P. lentiscus yielded an edible oil that is abundant in unsaturated FAs (UFAs), specifically oleic (52.36%-57.94%) and linoleic acids (16.03%-19.57%). The major tocol of HLHO (Hodna lentisk hot oil) was α-tocopherol at 59.96 mg/kg, whereas γ-tocopherol was the predominant tocol of HLCO (Hodna lentisk cold oil) at 19.64 mg/kg. β-Tocotrienol (8.11 mg/kg) and γ-tocotrienol (8.02 mg/kg) were the main tocotrienols of HLHO and HLCO, respectively. The subarid origin of P. lentiscus and the extraction method considerably influenced the physicochemical properties and the FA and tocol compositions of Hodna lentisk oils, especially HLCO, which were rich in UFAs and proved to be valuable sources of vitamin E. These oils could serve as alternatives to synthetic ingredients in the health, culinary, and personal care industries.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01018"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncovering Anti-Inflammatory Mechanisms of Elaeagnus angustifolia Extract via Metabolomic and Phytochemical Analyses. 通过代谢组学和植物化学分析揭示刺叶提取物的抗炎机制。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-09-29 DOI: 10.1002/cbdv.202502170

Amer Imraish, Marwa Seif, Lina Dahabiyeh, Afnan Al-Hunaiti, Mohammad Semreen, Malek Zihlif

{"title":"Uncovering Anti-Inflammatory Mechanisms of Elaeagnus angustifolia Extract via Metabolomic and Phytochemical Analyses.","authors":"Amer Imraish, Marwa Seif, Lina Dahabiyeh, Afnan Al-Hunaiti, Mohammad Semreen, Malek Zihlif","doi":"10.1002/cbdv.202502170","DOIUrl":"https://doi.org/10.1002/cbdv.202502170","url":null,"abstract":"Inflammation is a vital immune response that eliminates harmful stimuli. Building on our previous findings demonstrating the anti-inflammatory activity of Elaeagnus angustifolia (E. ang) aqueous crude extract at 20-80 µg/mL, this study explores its underlying mechanisms and potential biomarkers. Phytochemical profiling via liquid chromatography-tandem mass spectrometry (LC-MS/MS) identified key compounds, primarily quercetin and oleic acid. To further investigate its effects, we used an LC-MS-based metabolomics approach to analyze metabolic alterations in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells treated with 80 µg/mL of the extract. The treatment significantly altered cellular metabolism, revealing 156 differential metabolites, including amino acids, lipids, and nucleotides (pyrimidines and purines). Pathway analysis showed modulation of several metabolic routes, notably the TCA cycle, beta-oxidation, tyrosine metabolism, niacinamide salvage, and nucleotide metabolism. These results highlight the extract's capacity to modulate inflammation-related pathways at the metabolic level. Overall, our findings support the potential of E. ang aqueous extract as an antioxidant and anti-inflammatory agent. Furthermore, the study demonstrates the utility of metabolomics as a powerful tool for elucidating therapeutic mechanisms and identifying bioactive compounds in natural products.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02170"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pollenkitt From Narcissus tazetta: Evaluation of Its UV-Protective Potential as a Plant-Based Biomaterial Source. 水仙花粉基：作为植物基生物材料源的防紫外线潜力评价。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-09-29 DOI: 10.1002/cbdv.202502122

Aslıhan Çetinbaş-Genç, Orçun Toksöz, Özkan Kilin, Nüzhet Cenk Sesal, Giampiero Cai

{"title":"Pollenkitt From Narcissus tazetta: Evaluation of Its UV-Protective Potential as a Plant-Based Biomaterial Source.","authors":"Aslıhan Çetinbaş-Genç, Orçun Toksöz, Özkan Kilin, Nüzhet Cenk Sesal, Giampiero Cai","doi":"10.1002/cbdv.202502122","DOIUrl":"https://doi.org/10.1002/cbdv.202502122","url":null,"abstract":"Pollenkitt, the lipid-rich coating of pollen grains, is a promising natural ultraviolet (UV)-protective source rich in phenolic and flavonoid compounds. This study assessed the UV protection capacity of pollenkitt extracted from Narcissus tazetta using six solvents (dH2O, acetone, diethyl ether, ethanol, chloroform, and methanol). Methanol extracts showed the highest UV absorbance and sun protection factor (SPF) (17.8), despite 35% lower phenolics than ethanol, suggesting specific compounds like rutin and ferulic acid may drive UV protection. Surprisingly, although the dH2O extracts yielded less pollenkitt, they exhibited strong UV absorption SPF (19.1) and antioxidant activity from water-soluble compounds such as gentisic acid. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis predicted favorable bioavailability and low toxicity for most phenolics, with rosmarinic acid being predicted to possess properties associated with anticarcinogenic potential. However, rutin and naringenin were predicted to exhibit a skin sensitization risk. These findings underscore the potential of pollenkitt, specifically methanol and ethanol extracts, as a safe, natural UV shield for cosmetic, packaging, and coating applications.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02122"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Characterization, In Vitro Antidiabetic Activity, and Molecular Docking Studies of Isolated Compounds From Allamanda cathartica. 泻泻草中分离化合物的结构表征、体外抗糖尿病活性及分子对接研究。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-09-29 DOI: 10.1002/cbdv.202501183

Ritu Tomar, Shashank Shekher Mishra, Vivek Sahu, Jagannath Sahoo, Mandeep K Arora, Santosh Kumar Rath

{"title":"Structural Characterization, In Vitro Antidiabetic Activity, and Molecular Docking Studies of Isolated Compounds From Allamanda cathartica.","authors":"Ritu Tomar, Shashank Shekher Mishra, Vivek Sahu, Jagannath Sahoo, Mandeep K Arora, Santosh Kumar Rath","doi":"10.1002/cbdv.202501183","DOIUrl":"https://doi.org/10.1002/cbdv.202501183","url":null,"abstract":"Allamanda cathartica is a perennial shrub, traditionally used for the treatment of several ailments, including jaundice, malaria, and enlargement of the spleen. Besides ornamental values, the plant also possesses a wide variety of medicinal properties due to the presence of bioactive secondary metabolites of different chemical classes. The present work describes the phytochemical investigation of the leaf part of A. cathartica, which resulted in the isolation of five secondary metabolites (ACL 1-5) of different classes, including β-sitosterol (ACL-1), β-sitosterol glucoside (ACL-2), ursolic acid (ACL-3), plumieride (ACL-4), and pinitol (ACL-5). The compound ACL-5 was reported for the first time from the species. All the compounds were characterized by 1H NMR, 13C NMR, 2D NMR, and HRMS spectral analysis. Further to the plant extract, all the fractions and five isolated compounds were screened for in vitro α-amylase and α-glucosidase activity. The isolated compounds exhibited notable inhibitory activity against carbohydrate-hydrolyzing enzymes. For α-amylase inhibition, IC50 values ranged from 522.95 to 662.67 µg/mL, with plumieride showing the highest potency at a concentration of 522.95 µg/mL and pinitol acetate the lowest at 662.67 µg/mL. Similarly, for α-glucosidase inhibition, IC50 values ranged from 576.82 to 691.12 µg/mL, where plumieride again demonstrated the strongest activity at 576.82 µg/mL and pinitol acetate the lowest at 662.67 µg/mL. In support, all isolated compounds were taken further for molecular modelling studies to observe the rationale of our in vitro studies. Therefore, this work concludes that the isolated compounds ACL-4 and ACL-5 have demonstrated strong antidiabetic potential, with ACL-4 having a somewhat more powerful antidiabetic effect than ACL-5, according to both in vitro and docking experiments.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01183"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico and Experimental Evaluation of Myricetin in Insulin Resistance-Associated PCOS in Rats. 杨梅素对胰岛素抵抗相关性多囊卵巢综合征大鼠的影响。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-09-27 DOI: 10.1002/cbdv.202502165

Priya Aswal, Nitish Singh Jangwan, Swati Dobhal, Shradha Bisht, Mamta F Singh

{"title":"In Silico and Experimental Evaluation of Myricetin in Insulin Resistance-Associated PCOS in Rats.","authors":"Priya Aswal, Nitish Singh Jangwan, Swati Dobhal, Shradha Bisht, Mamta F Singh","doi":"10.1002/cbdv.202502165","DOIUrl":"https://doi.org/10.1002/cbdv.202502165","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a prevalent endocrinal disease characterized by hyperandrogenism, insulin resistance, cardiometabolic dysfunction, and hormonal disturbances, often leading to infertility. IR, a hallmark feature of PCOS, is observed in 30%-95% of women with PCOS. Current therapies are associated with potential side effects, necessitating exploration of alternative strategies. The present study aimed to identify and evaluate natural phytoconstituents targeting insulin receptor substrate-1 (IRS-1), a critical mediator in insulin signaling. In silico molecular docking of 22 phytoconstituents against IRS-1 revealed myricetin (MYR) has a binding energy of -9.3 kcal/mol, and favorable ADMET characteristics. MYR also showed significant binding affinity against PI3K and NF-κB (-8.6 and -7.0 kcal/mol, respectively), indicating its potential to improve insulin sensitivity. Subsequently, the therapeutic efficacy of MYR was assessed in a high-fat diet and letrozole induced PCOS in rats. MYR treatment at varying doses significantly (p < 0.001) reversed PCOS associated with metabolic and reproductive abnormalities. MYR (300 mg/kg) demonstrated substantial improvements in body weight, BMI, estrous cycle, restored hormonal balance, and improved IR. MYR significantly improved β-cell functions, serum lipid profile, oxidative stress, and histology in ovarian tissues. The findings of the study underscore the potential of MYR as safe and effective candidate for PCOS management.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02165"},"PeriodicalIF":2.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Next Generation of Integrated Eco-Friendly Anti-Biofouling and Anti-Biocorrosion Marine Natural Products. 新一代集成环保抗生物污染和抗生物腐蚀的海洋天然产品。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-09-27 DOI: 10.1002/cbdv.202502263

Jihan Azmi Miftah, Novriyandi Hanif, Lik Tong Tan, Sri Muljani, Nisa Rachmania Mubarik

{"title":"The Next Generation of Integrated Eco-Friendly Anti-Biofouling and Anti-Biocorrosion Marine Natural Products.","authors":"Jihan Azmi Miftah, Novriyandi Hanif, Lik Tong Tan, Sri Muljani, Nisa Rachmania Mubarik","doi":"10.1002/cbdv.202502263","DOIUrl":"https://doi.org/10.1002/cbdv.202502263","url":null,"abstract":"Marine organisms are known to biosynthesize complex anti-biofouling secondary metabolites offering a direct source of inspiration for scalable eco-friendly anti-biofouling and anti-biocorrosion agents for maritime industry-related applications. Biofouling and biocorrosion are interconnected issues that cannot be effectively addressed using traditional single-function antifouling or anticorrosion materials. To address these issues, a new approach is needed to search for dual eco-friendly anti-biofouling and anti-biocorrosion marine natural products. Such approach focuses on identifying molecules that aim to meet three key criteria: (1) environmentally friendly and biodegradable molecules with minimal toxicity, (2) biosurfactant properties to prevent microbial adhesion, and (3) disruption of bacterial biofilm formation by interfering with bacterial quorum-sensing (QS) systems, thereby reducing the risk of resistance development. This review explores the challenges and mechanisms driving biofouling and biocorrosion, and evaluates eco-friendly strategies, particularly those based on marine natural products, for antifouling and anticorrosion applications. It also highlights emerging sustainable solutions by outlining the rigorous criteria needed to guide the discovery of the next generation of environmentally friendly antifouling and anticorrosion agents.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02263"},"PeriodicalIF":2.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Characterization, Protective Effect on Diabetic Nephropathy of a Novel Polysaccharide From Trichosanthes kirilowii Maxim. Pericarp. 栝楼多糖的结构表征及对糖尿病肾病的保护作用。果皮。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-09-27 DOI: 10.1002/cbdv.202403380

Kunpeng Zhang, Qiaoying Song, Hankui Wu

{"title":"Structural Characterization, Protective Effect on Diabetic Nephropathy of a Novel Polysaccharide From Trichosanthes kirilowii Maxim. Pericarp.","authors":"Kunpeng Zhang, Qiaoying Song, Hankui Wu","doi":"10.1002/cbdv.202403380","DOIUrl":"https://doi.org/10.1002/cbdv.202403380","url":null,"abstract":"In this research, crude polysaccharide (Trichosanthes kirilowii Maxim. Pericarp polysaccharide [TMPP]) was extracted from T. kirilowii Maxim. pericarp by water extraction and alcohol precipitation, and the homogeneous polysaccharide (TMPP-1) was purified by Sephadex G-100 column. Subsequently, the structure of TMPP-1 was characterized by Fourier transform infrared spectroscopy (FT-IR), high-performance liquid chromatography (HPLC), gas chromatography, and nuclear magnetic resonance (NMR). After that, the effect and mechanism of TMPP-1 on kidney function injury in diabetic nephropathy (DN) mice were investigated. TMPP-1 structure analysis results showed that the TMPP-1 with molecular weight (MW) 4.52 kDa was composed of Man, Glc, and Gal with a molar ratio of 2.06:3.02:1.00. The methylation results showed that TMPP-1 was mainly composed of T-d-Glcp(1→, →4)-d-Glcp(1→, →4)-d-Galp(1→, →3)-α-d-Manp-(1→ and →3,6)-d-Glcp(1→ in a ratio of 0.62:2.0:1.0:2.06:0.2. The results of animal experiments showed that TMPP-1 could alleviate hyperglycemia symptoms and improve lipid levels, oxidative stress, and immune response in DN mice. These results revealed that TMPP had the potential to improve the clinical symptoms of DN. This study provided a theoretical basis for the utilization of the by-products of T. kirilowii Maxim.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e03380"},"PeriodicalIF":2.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0