Chemistry & Biodiversity最新文献_第2页

Research on the Metabolites and Biological Activities of the Endophytic Fungus Ilyonectria cyclaminicola From Epimedium koreanum Nakai. 韩国淫羊藿内生真菌环氏菌代谢产物及生物活性研究。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202402731

Rui Jiang, Mingxuan Zou, Li Yan, Hanning Liu, Xiaoting Qi, Xiao Lin, Yucui Liu, Jing Lei Xiao

{"title":"Research on the Metabolites and Biological Activities of the Endophytic Fungus Ilyonectria cyclaminicola From Epimedium koreanum Nakai.","authors":"Rui Jiang, Mingxuan Zou, Li Yan, Hanning Liu, Xiaoting Qi, Xiao Lin, Yucui Liu, Jing Lei Xiao","doi":"10.1002/cbdv.202402731","DOIUrl":"https://doi.org/10.1002/cbdv.202402731","url":null,"abstract":"This study aims to optimize the growth conditions of the endophytic fungus Ilyonectria cyclaminicola from the Korean Epimedium Nakai (EK), investigate whether I. cyclaminicola possesses the same anti-osteoporotic effects and kidney-injury effects as its host plant, identify the structure of its monomeric compounds and evaluate their antibacterial and antioxidant effects. The fermentation process was optimized through single-factor experiments, and the biological activity of the strain was assessed using a zebrafish model. Nuclear magnetic resonance was used to determine the structure of the monomeric compounds, and their antibacterial and antioxidant activities were evaluated using the paper disc diffusion method and DPPH free radical scavenging assay. The results showed that the optimal solid-state culture conditions for I. cyclaminicola were as follows: α-lactose as the carbon source, glycine as the nitrogen source, a temperature of 25°C, 12 h of natural light, and a pH of 6. Using wheat bran as the fermentation substrate, the total flavonoid content reached 28.431 mg/g after 60 days. I. cyclaminicola exhibits significant anti-osteoporotic and kidney-injury effects, and the nine isolated compounds all show varying degrees of DPPH radical scavenging and antibacterial activities. Among them, compound (2) 5-methylfurfural achieved a DPPH scavenging rate of 23.71% at 1.0 mg/mL.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02731"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, and Insecticidal Activity of Sulfonamide Structures Containing Methoxyamine as Potential Inhibitors of V-ATPase. 含有甲氧基胺作为v - atp酶抑制剂的磺胺结构的设计、合成和杀虫活性。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202500285

Peixu Wu, Mei Tian, Yi Long, Shaoxiong Wu, Ziguang Shang, Jingxiu Zhang, Yuanyuan Yang, Chaoyu Ren, Wenjun Wu, Jiwen Zhang

{"title":"Design, Synthesis, and Insecticidal Activity of Sulfonamide Structures Containing Methoxyamine as Potential Inhibitors of V-ATPase.","authors":"Peixu Wu, Mei Tian, Yi Long, Shaoxiong Wu, Ziguang Shang, Jingxiu Zhang, Yuanyuan Yang, Chaoyu Ren, Wenjun Wu, Jiwen Zhang","doi":"10.1002/cbdv.202500285","DOIUrl":"https://doi.org/10.1002/cbdv.202500285","url":null,"abstract":"Pesticides that act on unique targets are favored in pesticide research because of their unique mechanism of action and lower proneness to developing cross-resistance. In the previous work, the natural product cingulin V, which was isolated from Celastrus angulatus Maxim in our laboratory, was determined to act on the subunit H on V-ATPase. After homology modeling and virtual docking of the subunit H on V-ATPase, the highest scoring compound was selected for structural modification; two critical functional groups-the sulfonamide and propargyloxy moieties-were ultimately identified as being essential for the significant enhancement of insecticidal activity. On the basis of the previous work, to investigate whether the introduction of oxygen atoms into the sulfonamide structure can enhance the compound's biological activity, we synthesized 25 sulfonamide derivatives and evaluated their insecticidal activity against Mythimna separata. Bioassay results demonstrated that methoxyamine-substituted compounds exhibited significant efficacy at 0.5 mg/mL. Notably, compound 5.3 showed activity with an LC50 of 0.131 mg/mL, representing a 200-fold potency enhancement over celangulin V and a 5.26-fold improvement compared to the lead compound. Compound 5.3 was verified to act on ATPase as well through symptomological analysis and molecular docking. This study provided potential inhibitors of V-ATPase for the M. separata control.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00285"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FTIR Characterization and Bioactivity Assessment of Cinnamomum camphora Essential Oil: Antioxidant, Anti-Enzymatic, and Antifungal Properties Against Phytopathogens. 香樟精油的FTIR表征和生物活性评价：抗氧化、抗酶和抗真菌对植物病原体的作用。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202500720

Maroua Cheribot Cherif, Hicham Boughendjioua, Lucia Caputo, Ippolito Camele, Tarek Tahraoui, Vincenzo De Feo, Hazem S Elshafie

{"title":"FTIR Characterization and Bioactivity Assessment of Cinnamomum camphora Essential Oil: Antioxidant, Anti-Enzymatic, and Antifungal Properties Against Phytopathogens.","authors":"Maroua Cheribot Cherif, Hicham Boughendjioua, Lucia Caputo, Ippolito Camele, Tarek Tahraoui, Vincenzo De Feo, Hazem S Elshafie","doi":"10.1002/cbdv.202500720","DOIUrl":"https://doi.org/10.1002/cbdv.202500720","url":null,"abstract":"This study explores key biopharmaceutical properties of Cinnamomum camphora essential oil (EO), including antioxidant, anti-enzymatic, and antifungal activities, and evaluates its minimum inhibitory concentration (MIC) against some common phytopathogens. The functional groups of the EO were identified using Fourier-transform infrared (FTIR) spectroscopy. The antioxidant capacity, evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ABTS, and ferric-reducing antioxidant power (FRAP) methods, revealed a moderate activity. The antifungal activity assay showed a complete growth inhibition of Monilinia laxa, Monilinia fructicola, Sclerotinia sclerotiorum, Colletotrichum gloeosporioides, and Botrytis cinerea at a concentration of 10 000 ppm of the tested EO. However, the lowest antifungal activity (17.8%) was observed against Aspergillus niger only at the highest tested concentration. The measured MIC was 7000 ppm for M. laxa and 8000 ppm for C. gloeosporioides. The anti-enzymatic activities of the studied EO demonstrated a low inhibitory effect on cholinesterases (AChE and BChE), but the EO exhibited inhibitory concentration (IC50) values at 7.8 ± 0.6 and 2.78 ± 0.7 mg/mL for α-amylase and α-glucosidase, indicating a promising antidiabetic effect. This research revealed that the studied EO possesses various biological properties, indicating its potential applicability in several agro-pharmaceutical fields.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00720"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brazilian Biomes as Promising Resources of Rhodotorula Yeasts for the Biotechnological Production of Carotenoids. 巴西生物群落是类胡萝卜素生物技术生产的有前途的红酵母资源。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202500469

David Cristian Rodrigues Lucas, Renan Campos Chisté

引用次数: 0

Correction to "Anti-Herpes Simplex Virus Type 1 Activity Evaluation of Natural Derived Phloroglucinol Derivatives and Their Molecular Mechanisms Study". 对“天然衍生间苯三酚衍生物抗1型单纯疱疹病毒活性评价及其分子机制研究”的更正。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202501323

引用次数: 0

The Malaysian Natural Product Database: A Structure Repository of Malaysia's Natural Compounds. 马来西亚天然产物数据库：马来西亚天然化合物的结构储存库。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202501026

Khai-Lin Hew, Chze-Yin Tan, Yeun-Mun Choo

{"title":"The Malaysian Natural Product Database: A Structure Repository of Malaysia's Natural Compounds.","authors":"Khai-Lin Hew, Chze-Yin Tan, Yeun-Mun Choo","doi":"10.1002/cbdv.202501026","DOIUrl":"https://doi.org/10.1002/cbdv.202501026","url":null,"abstract":"The Malaysian Natural Product (MyNP) Database is a specialized resource designed to support natural product research, drug discovery, and cheminformatics. Developed through extensive data collection from SciFinder searches and manual curation of journal publications, MyNP comprises 1999 unique natural product structures. The database features a detailed classification system, with alkaloids (32%), sesquiterpenoids (10%), and flavonoids (8%) representing the most prominent chemical classes. It also includes key molecular descriptors such as two-dimensional structures, CAS numbers, IUPAC names, molecular weight, physicochemical properties, and safety-related parameters, making it highly suitable for computational analysis. Additionally, an analysis of the database identified 730 drug-like structures that comply with Lipinski's Rule of Five and meet additional safety criteria, including the absence of mutagenic, tumorigenic, reproductive, and irritant effects, as well as the exclusion of unfavorable functional groups and Pan-Assay Interference Compounds patterns. Compared to larger, well-established databases, MyNP offers a regionally focused dataset centered on Malaysia's natural products, effectively integrating biodiversity-driven research with cheminformatics applications. Its offline accessibility, structured classification, and cost-effective design make it a valuable resource for structure-activity relationship studies and computational screening in drug discovery.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01026"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant Secondary Metabolites From Marine-Derived Fungi: Chemical Diversity and Bioactivity Profiling. 海洋真菌的抗氧化次生代谢物：化学多样性和生物活性分析。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202500901

Yao-Yao Zheng, He Zhang, Hao Yin, Jing Jia, Xiao-Qian Liu, Chang-Yun Wang

{"title":"Antioxidant Secondary Metabolites From Marine-Derived Fungi: Chemical Diversity and Bioactivity Profiling.","authors":"Yao-Yao Zheng, He Zhang, Hao Yin, Jing Jia, Xiao-Qian Liu, Chang-Yun Wang","doi":"10.1002/cbdv.202500901","DOIUrl":"https://doi.org/10.1002/cbdv.202500901","url":null,"abstract":"Oxidation is an integral part of the aerobic processes in life and serves as a critical basis for life activities. Reactive oxygen species (ROS), natural by-products of oxygen metabolism, are present at low levels in the organism and play a crucial role in maintaining cell cycle and gene expression in the body. An imbalance in the oxidative-antioxidative system is associated with numerous human diseases. Consequently, exploring natural antioxidants and investigating their impact on human health has become a pivotal research focus. Marine-derived fungi represent a significant resource for discovering natural products due to their structural diversity and broad range of biological activities. This review highlights the potential of marine-derived fungi as sources of antioxidant compounds. A total of 41 studies, describing 168 secondary metabolites with antioxidant properties isolated from 38 marine-derived fungal strains across 19 genera, were reviewed. The sources, unique structures, and bioactivities of these antioxidant compounds were systematically compiled. This review provides a valuable reference for the current research landscape of natural products from marine-derived fungi and reveals that marine natural products have important medicinal values and are worthy of in-depth investigation.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00901"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Target Screening and Validation of the Antitumor Effect of Saponin Extract From Holothuria leucospilota. 白花海棠皂苷提取物抗肿瘤作用的靶点筛选与验证。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202403399

Fuju Xu, Guangchun Liu, Chujie Zhao, Shenglin Zhang, Ruoyan Lin, Xudong Cao, Zonghe Yu, Peng Luo, Wen Huang, Lihong Yuan

{"title":"Target Screening and Validation of the Antitumor Effect of Saponin Extract From Holothuria leucospilota.","authors":"Fuju Xu, Guangchun Liu, Chujie Zhao, Shenglin Zhang, Ruoyan Lin, Xudong Cao, Zonghe Yu, Peng Luo, Wen Huang, Lihong Yuan","doi":"10.1002/cbdv.202403399","DOIUrl":"https://doi.org/10.1002/cbdv.202403399","url":null,"abstract":"This paper aimed to isolate and characterize the saponins from Holothuria leucospilota and investigate their potential antitumor effects and antitumor targets using network pharmacology and bioinformatics. The purified saponins were analyzed using electrospray ionization-tandem mass spectrometry (ESI-MS/MS). Ten saponins were identified. The in vitro experiments demonstrated that H. leucospilota saponins exhibited significant dose-dependent inhibition on HepG2, Panc02, and UM-UC-3 cell proliferation and differentiation. In addition, through network pharmacology, bioinformatics, and molecular docking, a total of 22 key tumor targets of H. leucospilota saponins were identified. Then, the reverse-transcription quantitative polymerase chain reaction (RT-qPCR) results showed that the saponins from H. leucospilota can inhibit the expression of target genes AURKB, BIRC5, CHEK1, PTGS2, and MMP9, and may affect the neuroactive ligand-receptor signaling pathway, thereby suppressing tumor proliferation and migration. In conclusion, we have demonstrated that the saponin extract from H. leucospilota has potential application value in tumor therapy.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e03399"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory and Immunomodulatory Phytochemicals for Management of Oral Lichen Planus: A Multi-Omics System Biology and Experimental Assessment. 抗炎和免疫调节植物化学物质对口腔扁平苔藓的治疗：多组学系统生物学和实验评估。

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202500662

Alaka Sahoo, Shasank S Swain, Satya R Singh, Ajaya K Jena, Sudhir K Paidesetty, Maitreyee Panda

{"title":"Anti-Inflammatory and Immunomodulatory Phytochemicals for Management of Oral Lichen Planus: A Multi-Omics System Biology and Experimental Assessment.","authors":"Alaka Sahoo, Shasank S Swain, Satya R Singh, Ajaya K Jena, Sudhir K Paidesetty, Maitreyee Panda","doi":"10.1002/cbdv.202500662","DOIUrl":"https://doi.org/10.1002/cbdv.202500662","url":null,"abstract":"Oral lichen planus (OLP) is a chronic autoimmune inflammatory disorder where the exact pathophysiology remains unclear, posing challenges to effective treatment. The accumulative evidence suggested that anti-inflammatory and immunomodulatory phytochemicals showed alternative therapeutic effects. Accordingly, the present study selected 28 multimodal phytochemicals (P1 to P28) and further assessed their potency and drug-ability using computer-aided drug design (CADD) and experimental methods. At first, the putative targets for OLP were selected through network pharmacology, and then molecular docking scores with predicted drug-ability profiles recommended that P12 (epicatechin gallate/ECG) be the lead candidate among all. Furthermore, the protein-ligand stability of ECG against the nonsteroidal target cyclooxygenase-2 (COX-2) and the steroidal target glucocorticoid receptor (GR) was investigated using molecular dynamics (MD) simulations over 200 ns, and free energy calculations (MM/PBSA) were performed with GROMACS-2020 software. The nontoxic dose for ECG was observed to be > 100 µM in three cell lines (HEK293, Huh7, and THP-1). The gene expression results demonstrated that the COX-2 and the proinflammatory cytokine IL-1β significantly reduced, and the anti-inflammatory cytokine IL-10 slightly increased in a concentration-dependent manner in inflammation-induced (LPS-treated) THP-1 cells. Overall, the systematic computational and experimental results suggested that ECG could be a potent therapeutic option for managing OLP among the listed treatments.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00662"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Investigation of the Thermostable Branched-Chain Transaminase From Aeribacillus pallidus: Identification, Characterization, and Application (Chem. Biodiversity 5/2025) 封面：白芽孢杆菌耐热支链转氨酶的研究：鉴定、表征和应用（化学）。生物多样性的5/2025)

IF 2.3 3区化学

Chemistry & Biodiversity Pub Date : 2025-06-16 DOI: 10.1002/cbdv.202570601

Mengze Zheng, Xiaole Yang, Jiahuan Li, Chuanzhi Zhang, Shaojie Ma, Dahua Shi, Yang Cao, Tingting Li

引用次数: 0