Chemistry & Biodiversity最新文献_第2页

Chemical Composition and Repellent Activity of Strobilanthes tonkinensis Foliar Extract and Its Fractions Against Tribolium castaneum. 桔梗叶提取物及其组分对蓖麻虫的化学成分及驱避活性研究。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71817

Youwu Hao, Xunyou Wang, Junhua Zhu, Pu Miao, Dongling Wu, Xifa Yang, Jiakai Wu, Xiangyang Liu

{"title":"Chemical Composition and Repellent Activity of Strobilanthes tonkinensis Foliar Extract and Its Fractions Against Tribolium castaneum.","authors":"Youwu Hao, Xunyou Wang, Junhua Zhu, Pu Miao, Dongling Wu, Xifa Yang, Jiakai Wu, Xiangyang Liu","doi":"10.1002/cbdv.71817","DOIUrl":"10.1002/cbdv.71817","url":null,"abstract":"Protecting stored grains from pest infestation (e.g., Tribolium castaneum) is crucial for cereal preservation and food safety. The insecticides commonly used for grain storage can leave toxic residues or byproducts that pollute the environment and harm humans. In this study, the repellent activity of natural products from Strobilanthes tonkinensis Lindau leaves against T. castaneum was investigated. Thirty-five chemical components were tentatively identified, and the repellent activities of the crude extract, its fractions, and estragole were evaluated. At the same concentrations (1%, equivalent to 10 mg/mL or 157.27 µg/cm2), the extracts (after 16 and 24 h of exposure) and Fraction 1 (after 6 h of exposure) exhibited repellency comparable to that of the positive control (DEET) against T. castaneum adults. The repellent activity and mechanism of estragole, a constituent of Fraction 1, were further investigated. The results indicated that estragole exerted dose- and time-dependent repellent effects. Moreover, similar to the commercial repellent DEET, estragole significantly upregulated the expression of the odorant-binding protein TcOBPC11 and chemosensory protein TcCSP9. In conclusion, natural products derived from S. tonkinensis leaves, including both the extracts and specific compound estragole, showed promising repellent activities, suggesting their potential as alternative agents for the management of T. castaneum.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71817"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical Characterisation and In Vitro Bioactivity of Sumac (Rhus coriaria)-Derived Exosome-Like Nanoparticles. 漆树（Rhus coriaria）衍生的外泌体样纳米颗粒的理化特性和体外生物活性。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71833

Dilek Bahar

{"title":"Physicochemical Characterisation and In Vitro Bioactivity of Sumac (Rhus coriaria)-Derived Exosome-Like Nanoparticles.","authors":"Dilek Bahar","doi":"10.1002/cbdv.71833","DOIUrl":"10.1002/cbdv.71833","url":null,"abstract":"Plant-derived exosome-like nanoparticles (PELNs) are attracting increasing interest in biomedical research due to their natural origin and components. In this study, PELNs were isolated from Rhus coriaria and physicochemical properties and in vitro biological activities were evaluated. The isolated PELNs were characterised using FE-SEM, nanoparticle-tracking-analysis (NTA) and flow cytometry; chemical composition was analysed by GC-MS. Biological effects were evaluated in A549, HepG2, MCF-7 and PC-3 tumour cells and normal human fibroblasts (hFib) in terms of proliferation, apoptosis and intracellular reactive oxygen species (ROS). The IC50 values for PELNs were determined to be 55.96, 50.0, 26.0 and 49.0 µg protein equivalent/mL in A549, HepG2, MCF-7 and PC-3 cells, respectively, while in hFib cells, the value was 181.5 µg protein equivalent/mL. This difference indicated that PELNs exerted a greater cytotoxic effect on tumour cells than on normal fibroblasts. PELN treatment altered apoptosis and intracellular ROS levels in tumour cells in a cell line-dependent manner. GC-MS analysis identified tetradecanoic acid, 9-hexadecenoic acid, 9-octadecenoic acid and 9-octadecenamide as the major components. The findings suggest a relationship worth investigating between the chemical composition of PELNs from R. coriaria and their cellular bioactivity and that their selective anti-cancer potential should be examined through further mechanistic studies.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71833"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Antioxidant, Antibacterial, and Cholinesterase-Inhibitory Properties of an Aqueous Euphorbia macroclada Root Extract Obtained by Ultrasound-Assisted Extraction. 超声辅助提取大戟根提取物的体外抗氧化、抗菌和胆碱酯酶抑制特性

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71825

Abdulkadir Gül, Fırat Yılmaz, Fevzi Topal, İnanç Özgen, Ercan Aydoğmuş, Hasan Arslanoğlu

{"title":"In Vitro Antioxidant, Antibacterial, and Cholinesterase-Inhibitory Properties of an Aqueous Euphorbia macroclada Root Extract Obtained by Ultrasound-Assisted Extraction.","authors":"Abdulkadir Gül, Fırat Yılmaz, Fevzi Topal, İnanç Özgen, Ercan Aydoğmuş, Hasan Arslanoğlu","doi":"10.1002/cbdv.71825","DOIUrl":"10.1002/cbdv.71825","url":null,"abstract":"In the present study, the aqueous extract obtained from the roots of Euphorbia macroclada via ultrasound-assisted extraction (Ult-ER) was evaluated for its anticholinesterase (AChE and BChE), antioxidant, and antibacterial activities. While the extract exhibited weak inhibition against AChE (IC50: 507.69 ± 17.95 mg/mL), it showed relatively greater inhibitory activity against BChE (IC50: 22.41 ± 0.49 mg/mL). In antioxidant assays, Ult-ER exhibited measurable antioxidant responses, with DPPH and ABTS+ radical-scavenging capacities of 18.33 ± 0.49 and 119.59 ± 1.86 mg TE/L, respectively. Its Fe3 + and Cu2 + reducing capacities were 128.51 ± 12.57 and 670.33 ± 11.59 mg TE/L, respectively. The total phenolic and flavonoid contents were 84.80 ± 3.31 mg GAE/g and 60.67 ± 2.29 mg QE/g, while the total antioxidant capacity was 9.78 ± 0.44 mg TE/g and 15.62 ± 1.85 mg BHAE/g. In the antibacterial evaluation, Ult-ER at the highest tested concentration of 8 mg/mL exhibited inhibitory activity against all tested strains, including Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853, whereas no detectable inhibition was observed at lower concentrations.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71825"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review of Antidiabetic Mechanisms of Passiflora edulis: Beyond Glycemic Control. 西番莲抗糖尿病机制的系统综述：超越血糖控制。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71700

Luiz Ricardo Teixeira de Farias, Mariáurea Matias Sarandy, Reggiani Vilela Gonçalves, Emanuella de Aragão Tavares, Silvana Maria Zucolotto

{"title":"A Systematic Review of Antidiabetic Mechanisms of Passiflora edulis: Beyond Glycemic Control.","authors":"Luiz Ricardo Teixeira de Farias, Mariáurea Matias Sarandy, Reggiani Vilela Gonçalves, Emanuella de Aragão Tavares, Silvana Maria Zucolotto","doi":"10.1002/cbdv.71700","DOIUrl":"https://doi.org/10.1002/cbdv.71700","url":null,"abstract":"Passiflora edulis, commonly known as passion fruit, is traditionally used in various cultures for its calming and antidiabetic effects. This systematic review aimed to evaluate the potential of P. edulis on DM based on preclinical evidence from in vivo studies. This review was performed according to the PRISMA guide, using a structured search on the Embase, PubMed-Medline, Web of Science, Cochrane and Scopus platforms. Twenty-two studies met the inclusion criteria, and 18 reported antihyperglycemic effects of the plant, either alone or as an adjunct to insulin. Additional benefits included improvements in lipid and antioxidant profiles. The fruit was used in 16 studies, with the peel being the most frequent and effective part (11 studies), likely related to its high content of pectin, phenolics, and flavonoids. Proposed mechanisms include delayed intestinal glucose absorption, stimulation of insulin secretion, partial regeneration of pancreatic β-cells, activation of the PI3K/AKT and AMPK pathways, and antioxidant and hypolipidemic actions. Despite these promising findings, significant methodological limitations, such as lack of dose and extraction process standardization and insufficient phytochemical characterization, affect reproducibility. Nevertheless, the data suggest that passion fruit peel, an often-discarded agro-industrial by-product, may represent a promising source of bioactive compounds for diabetes research.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71700"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Activity of Cotula cinerea Essential Oil: Integrated Chemical, In Vivo, Histological, and Computational Evaluation. 药膏精油的抗炎活性：综合化学、体内、组织学和计算评价。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71793

Habiba Haddad, Mohammed Larbi Benamor, Yahia Bekkar, Ouafa Boudebia, Salah Neghmouche Nacer, Elhafnaoui Lanez, Aicha Adaika, Taher M Abdelhameed, Lazhar Bechki, Touhami Lanez, Stefania Garzoli

{"title":"Anti-Inflammatory Activity of Cotula cinerea Essential Oil: Integrated Chemical, In Vivo, Histological, and Computational Evaluation.","authors":"Habiba Haddad, Mohammed Larbi Benamor, Yahia Bekkar, Ouafa Boudebia, Salah Neghmouche Nacer, Elhafnaoui Lanez, Aicha Adaika, Taher M Abdelhameed, Lazhar Bechki, Touhami Lanez, Stefania Garzoli","doi":"10.1002/cbdv.71793","DOIUrl":"10.1002/cbdv.71793","url":null,"abstract":"The anti-inflammatory activity of Cotula cinerea essential oil (EO) was evaluated using integrated chemical, in vivo, histological, and computational approaches. Gas chromatography-mass spectrometry (GC-MS) identified trans-thujone (51.86%), santolina triene (10.60%), and sabinene (6.17%) as the most abundant constituents. In benzylthiouracil (BTU)-treated Wistar rats, EO administration reduced the liver and kidney indices from 4.36% to 2.70% and from 0.65% to 0.52%, respectively; red blood cell count increased from 4.90 to 7.17 × 1012/L and hemoglobin from 9.40 to 15.40 g/dL. Aspartate aminotransferase decreased from 226.06 to 111.10 U/L and alanine aminotransferase from 116.00 to 71.56 U/L. C-reactive protein and renal markers also moved toward control values, and histological examination showed improved liver and kidney architecture. Computational analyses were used as hypothesis-generating complements to the experimental findings. Molecular docking predicted the most favorable cyclooxygenase-2 (COX-2) scores for cis-verbenyl acetate (CVA; -7.01 kcal/mol) and camphor (CAM; -6.66 kcal/mol). Molecular dynamics (MD) trajectories and molecular mechanics/Poisson-Boltzmann surface area (MM-PBSA) estimates indicated persistent simulated interactions, with COX-2 binding free energies of -43.67 ± 3.80 and -39.93 ± 2.59 kcal/mol, respectively. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) outputs were favorable for CVA and CAM but remain predictive.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71793"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Characterization and Biological Activity of Stachys pinardii Extracts. 木竹提取物的植物化学特性及生物活性研究。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71812

Zeyneb Karakus, Cengiz Sarikurkcu, Arzuhan Sihoglu

{"title":"Phytochemical Characterization and Biological Activity of Stachys pinardii Extracts.","authors":"Zeyneb Karakus, Cengiz Sarikurkcu, Arzuhan Sihoglu","doi":"10.1002/cbdv.71812","DOIUrl":"10.1002/cbdv.71812","url":null,"abstract":"The study investigated how solvent choice affects the extraction of bioactive phytochemicals from Stachys pinardii. Methanol and aqueous extracts of aerial parts were obtained using ultrasound-assisted extraction and analyzed for phytochemical content, antioxidant capacity, and enzyme inhibition. The methanol extract showed higher total phenolic (52.56 mg GAEs/g) and flavonoid contents (18.19 mg REs/g) than the aqueous extract (15.62 mg GAEs/g and 8.25 mg REs/g). Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) analysis identified verbascoside and chlorogenic acid as major compounds in methanol, while aqueous extract was richer in caffeic acid and hydroxycinnamic derivatives. Despite lower phenolic content, the aqueous extract demonstrated stronger antioxidant activity across 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), cupric ion reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, with lower IC50/EC50 values. It also exhibited superior enzyme inhibitory effects, particularly against α-amylase (2.52 mg/mL) and α-glucosidase (1.58 mg/mL), although its inhibitory activity remained lower than that of the standard acarbose. Overall, solvent polarity significantly influences both phytochemical composition and biological activity. The aqueous extract, despite its lower total quantified phenolic content, shows promising multifunctional bioactivity. Further studies should focus on bioactivity-guided fractionation and mechanistic insights into individual compounds.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71812"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlorothiophene-Substituted N-Phenylpyrazolines: Synthesis, Anticancer Evaluation, and Computational Insight into COX-2 Inhibition. 氯噻吩取代的n -苯基吡唑啉：合成、抗癌评价和对COX-2抑制的计算洞察。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71787

Nikma Farismatur Riza, Fia Fathiana Wulan, Tegar Asanda Ghifari, Endang Astuti, Tutik Dwi Wahyuningsih

{"title":"Chlorothiophene-Substituted N-Phenylpyrazolines: Synthesis, Anticancer Evaluation, and Computational Insight into COX-2 Inhibition.","authors":"Nikma Farismatur Riza, Fia Fathiana Wulan, Tegar Asanda Ghifari, Endang Astuti, Tutik Dwi Wahyuningsih","doi":"10.1002/cbdv.71787","DOIUrl":"10.1002/cbdv.71787","url":null,"abstract":"Cancer remains a leading cause of mortality worldwide, highlighting the need for novel anticancer agents. Pyrazoline derivatives have attracted considerable interest due to their structural flexibility, enabling modifications, including bioisosteric replacement, to enhance anticancer potential. In this study, eight N-phenylpyrazoline analogs bearing chlorothiophene moieties were synthesized via cyclocondensation of chalcone intermediates with phenylhydrazine, yielding 59%-94%. Structural characterization was confirmed using ATR-IR, GC-MS, 1H-, and 13C-NMR analyses. The synthesized derivatives (2a-2h) were assessed for cytotoxicity against the T47D, MCF7, and WiDr cancer cell lines, along with normal Vero cells, using the MTT assay. Selectivity was determined by comparing cytotoxic effects on cancer versus normal cells. Among the compounds, 5-(benzo[d][1,3]dioxol-5-yl)-3-(5-chlorothiophen-2-yl)-1-phenyl-4,5-dihydro-1H-pyrazole (2g) exhibited the most potent cytotoxicity against WiDr cells (IC50 = 19.63 µg/mL) and the highest selectivity index (SI = 665.88). Molecular docking revealed strong binding affinities of compound 2g to COX-2 (-10.5 kcal/mol), supported by favorable pharmacokinetic properties.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71787"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenols as Natural Therapeutics for Dental Infections and Oral Inflammation: Mechanisms and Clinical Perspectives. 多酚作为牙齿感染和口腔炎症的天然疗法：机制和临床前景。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71818

Deepa Subramanian, Divya Krishnamoorthi, Gowtham Kannan, Benedict Mathews Paul

{"title":"Polyphenols as Natural Therapeutics for Dental Infections and Oral Inflammation: Mechanisms and Clinical Perspectives.","authors":"Deepa Subramanian, Divya Krishnamoorthi, Gowtham Kannan, Benedict Mathews Paul","doi":"10.1002/cbdv.71818","DOIUrl":"10.1002/cbdv.71818","url":null,"abstract":"Oral diseases such as dental caries, periodontitis, denture-related stomatitis, and oral mucositis are prevalent global health concerns primarily driven by microbial dysbiosis and chronic inflammation. Conventional treatments, including antibiotics and mechanical plaque control, have limitations due to antimicrobial resistance and adverse effects. Polyphenols, a diverse class of bioactive phytochemicals, exhibit promising antimicrobial, anti-inflammatory, and antioxidant properties that can be leveraged for oral health management. This review explores the therapeutic potential of polyphenols in targeting key pathogenic mechanisms associated with oral diseases. Polyphenols exert antimicrobial effects by disrupting bacterial membrane integrity, inhibiting biofilm formation, and interfering with quorum sensing pathways of oral pathogens such as Streptococcus mutans and Porphyromonas gingivalis. Additionally, their anti-inflammatory properties involve modulation of NF-κB signaling, suppression of pro-inflammatory cytokines (IL-1β, TNF-α, COX-2), and attenuation of oxidative stress through upregulation of endogenous antioxidants. Polyphenols also influence oral microbiota composition, promoting a balanced microbial ecosystem that supports oral health. However, challenges such as poor bioavailability, stability, and interindividual variability in response remain major hurdles. Advances in nanotechnology and controlled-release systems offer promising strategies to enhance polyphenol efficacy in dental applications. Further research is needed to optimize their formulation, delivery, and clinical validation to establish evidence-based polyphenol-based interventions in dentistry.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71818"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Detection Probes for Vanin-1: Development and Biological Applications in Various Inflammatory Diseases. Vanin-1检测探针的研究进展及其在各种炎症疾病中的生物学应用

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71837

Shumei Wang, Xing Li

{"title":"A Review of Detection Probes for Vanin-1: Development and Biological Applications in Various Inflammatory Diseases.","authors":"Shumei Wang, Xing Li","doi":"10.1002/cbdv.71837","DOIUrl":"10.1002/cbdv.71837","url":null,"abstract":"Vascular non-inflammatory molecule-1 (Vanin-1), also known as pantetheinase, is a key enzyme that regulates oxidative stress, inflammatory responses, and metabolic processes by catalyzing the hydrolysis of pantetheine into cysteamine and pantothenic acid. Recent studies have progressively elucidated its pivotal role in various pathological processes, including acute kidney injury (AKI), inflammatory bowel disease (IBD), liver injury, and rheumatoid arthritis (RA). As an important biomarker for early diagnosis and assessment of treatment efficacy, it has attracted widespread attention and driven the rapid development of highly sensitive and specific detection tools. This article provides a systematic review of Vanin-1 probes developed in recent years, covering fluorescent, chemiluminescent, bioluminescent, and electrochemical sensors, with a focus on their molecular design principles, detection mechanisms, performance characteristics, and biological applications. In addition, this article outlines future trends in Vanin-1 probe technologies, providing a comprehensive theoretical and methodological reference to support further basic research and clinical translation applications related to Vanin-1.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71837"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic Dihydroagarofuran Sesquiterpenoids Isolated From the Roots of Tripterygium wilfordii. 雷公藤根中细胞毒性双氢木脂呋喃倍半萜类化合物的分离。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71803

Ya-Lin Hu, Yi-Ping Xie, Jing-Yi Huang, Chong Wang, Jia-Li Huang, Wen-Jie Chen, Zhen Li, Zuo-Dong Qin

引用次数: 0