Chemistry & Biodiversity最新文献_第2页

Compositional Analysis of Cultivated and Wild-Harvested Boswellia sacra Frankincense Resin Essential Oils in Oman. 阿曼栽培和野生乳香树脂精油的成分分析。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-22 DOI: 10.1002/cbdv.202502268

Anjanette DeCarlo, Stephen Johnson, Salah Agieb, Prabodh Satyal, Aaron Sorensen, William N Setzer

{"title":"Compositional Analysis of Cultivated and Wild-Harvested Boswellia sacra Frankincense Resin Essential Oils in Oman.","authors":"Anjanette DeCarlo, Stephen Johnson, Salah Agieb, Prabodh Satyal, Aaron Sorensen, William N Setzer","doi":"10.1002/cbdv.202502268","DOIUrl":"https://doi.org/10.1002/cbdv.202502268","url":null,"abstract":"Frankincense is a valuable aromatic resin, used globally for its scent, therapeutic properties, and religious significance. All frankincense is currently harvested from wild Boswellia trees, but recent research has identified serious social and environmental challenges in wild supply chains, including significant population declines in multiple frankincense species. Cultivation of Boswellia trees in commercial plantations could be a possible solution to these challenges, but there have been widespread misgivings amongst harvesting communities and industry whether cultivated plants could produce essential oils of sufficient complexity to match existing wild-harvested stocks. We collected resin samples from both cultivated and wild individual frankincense trees in southern Oman, and compared them with wild harvesting-derived commercial frankincense essential oil samples. The cultivated tree samples were similar to existing wild-derived commercial samples, with no loss of phytochemical complexity. We also found a previously unreported δ-3-carene/α-pinene chemotype in the individual wild tree samples. The results indicate that plantation-produced frankincense could replicate current wild-harvested commercial batches, but that there is under-explored phytochemical diversity in the species, which necessitates caution in plantation stock selection. In addition, movement from wild harvesting to cultivation can have mixed social and conservation impacts, especially for a product with the cultural and livelihood significance of frankincense. Care must therefore be taken to ensure that potential positive impacts are realized, and potential negative impacts are fully mitigated.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02268"},"PeriodicalIF":2.5,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Mechanism Underlying Diyu Shengbai Tablet in Remediating Leukopenia Based on Network Pharmacology, Metabonomics, and Fecal Transcriptomics. 基于网络药理学、代谢组学和粪便转录组学揭示地瘀生白片治疗白细胞减少的机制。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-20 DOI: 10.1002/cbdv.202501772

Erbing Wang, Ying Wang, Tingli Qu, Yan Yang, Yuying Zhao

{"title":"Unveiling the Mechanism Underlying Diyu Shengbai Tablet in Remediating Leukopenia Based on Network Pharmacology, Metabonomics, and Fecal Transcriptomics.","authors":"Erbing Wang, Ying Wang, Tingli Qu, Yan Yang, Yuying Zhao","doi":"10.1002/cbdv.202501772","DOIUrl":"https://doi.org/10.1002/cbdv.202501772","url":null,"abstract":"We aimed to integrate network pharmacology, metabonomics, and fecal transcriptomics to elucidate the mechanism of action of Diyu Shengbai Tablets (DST) in leukopenia treatment. Key bioactive components and core targets of DST in leukopenia were identified using network pharmacology. Spleen metabonomics, fecal transcriptomics, and MetOrigin analysis were employed to investigate potential mechanisms. Molecular docking, molecular dynamics simulations, and enzyme-linked immunosorbent assay were performed to validate findings. Network pharmacology predicted Hypericin and Quercetin-3-galactoside-7-glucoside as major active constituents of DST. metabonomic analysis identified alterations in 133 differential metabolites in the spleen, with linoleic acid metabolism as the primary affected pathway. 16S rRNA sequencing indicated normalization of Lactobacillus abundance. Molecular docking and dynamics simulations showed low binding free energies between active compounds (e.g., Hypericin) and targets such as PIK3CA and SRC. Serum levels of Mouse interleukin-6 and Granulocyte colony-stimulating factor were elevated following DST intervention. DST modulates spleen metabolic profiles in leukopenic mice, restores gut microbial composition, and exerts therapeutic effects by regulating linoleic acid metabolism and influencing the PI3K-Akt signaling pathway. These findings provide a foundation for further exploration of multi-target mechanisms in traditional Chinese medicine for leukopenia management.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01772"},"PeriodicalIF":2.5,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining Molecular Biodiversity Using Aniline Blue to Detect β-1,3-Glucans. 利用苯胺蓝检测β-1,3-葡聚糖检测分子生物多样性。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-20 DOI: 10.1002/cbdv.202501557

Jieyi Long, Zhonghui Qiao, Yuan Wang, Andong Zhou, Yibing Wang, Mengshan Zhang, Yong Zhou, Kevin H Mayo, Lin Sun, Yifa Zhou

{"title":"Examining Molecular Biodiversity Using Aniline Blue to Detect β-1,3-Glucans.","authors":"Jieyi Long, Zhonghui Qiao, Yuan Wang, Andong Zhou, Yibing Wang, Mengshan Zhang, Yong Zhou, Kevin H Mayo, Lin Sun, Yifa Zhou","doi":"10.1002/cbdv.202501557","DOIUrl":"https://doi.org/10.1002/cbdv.202501557","url":null,"abstract":"β-1,3-Glucans are widely used in food and pharmaceuticals, such that testing for them is crucial to their appropriate application. Using the aniline blue method is a convenient way to test for β-1,3-glucans. However, the conditions used to detect them are quite varied and need to be standardized for all investigators. Here, we established a protocol that optimizes key parameters, including NaOH concentration (0.6 M), depolymerization temperature (40°C), reaction time (10 min), and dye-binding temperature (30°C) using curdlan as a reference. We found that the fluorescence intensity of aniline blue binding was negatively correlated with branching in β-1,3-glucans and positively correlated with molecular weight. A correction factor CF = -0.471 + 0.163·ln(a) × (1 - 0.550b), with a for molecular weight and b for branching degree, was developed to correct for structural diversity. This enabled accurate quantification among structurally different β-1,3-glucans. Overall, our results will greatly improve the accuracy and precision to detect β-1,3-glucans and provide a reliable method for their analysis.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01557"},"PeriodicalIF":2.5,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two New Epimeric Decalinoylspirotetramic Acid Derivatives From the Acanthus ilicifolius-Derived Fungus Trichoderma sp. RSF-1. 从棘木霉衍生真菌中分离出的两个新的十烷酰螺戊酸衍生物。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-20 DOI: 10.1002/cbdv.202501954

Jiao-Jiao Li, Hao-Wei Liu, Guang-Shan Yao, Yao-Yao Zheng, Ya-Hui Zhang, Pingyuan Wang, Chang-Yun Wang

引用次数: 0

Exploring the Antidiabetic Mechanisms of Taraxacum farinosum and Taraxacum mirabile Extracts: Enzyme Inhibition, Insulin Secretion, and LC-HRMS-Based Phytochemical Analysis. 探究粉蒲公英和奇异蒲公英提取物的抗糖尿病机制：酶抑制、胰岛素分泌和基于lc - hrms的植物化学分析

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-18 DOI: 10.1002/cbdv.202501160

Leyla Paşayeva, Ayşe Kübra Karaboğa Arslan, Hanifa Fatullayev, Esra Köngül Şafak, Osman Tugay, Mükerrem Betül Yerer

{"title":"Exploring the Antidiabetic Mechanisms of Taraxacum farinosum and Taraxacum mirabile Extracts: Enzyme Inhibition, Insulin Secretion, and LC-HRMS-Based Phytochemical Analysis.","authors":"Leyla Paşayeva, Ayşe Kübra Karaboğa Arslan, Hanifa Fatullayev, Esra Köngül Şafak, Osman Tugay, Mükerrem Betül Yerer","doi":"10.1002/cbdv.202501160","DOIUrl":"https://doi.org/10.1002/cbdv.202501160","url":null,"abstract":"Taraxacum farinosum and Taraxacum mirabile are endemic species traditionally used to treat diabetes. This study investigated the antidiabetic, antioxidant, and phytochemical properties of methanol extracts of aerial and root parts of both species and sub-extracts (n-hexane, dichloromethane, ethyl acetate, n-butanol, and water) derived from the active T. farinosum methanol extract. Enzyme inhibition assays revealed that the methanol extract (TFA) and ethyl acetate sub-extract (TFAEA) of T. farinosum showed superior α-amylase inhibition compared to the standard drug acarbose. In contrast, moderate inhibition was observed against α-glucosidase. The same extracts also demonstrated high total phenolic and flavonoid contents and exhibited vigorous radical scavenging activity in DPPH, 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), and FRAP assays. In cell line studies, the extracts showed a noncytotoxic effect at 1000 µg/mL on β-TC6 cell proliferation and enhanced insulin secretion in a glucose concentration-dependent manner (0-25 mM). LC-HRMS analysis identified ferulic acid as the major compound, along with luteoloside and liquiritigenin, which may contribute to the observed bioactivities. These results suggest that T. farinosum possesses multifaceted antidiabetic potential through enzyme inhibition, β-cell stimulation, and antioxidant mechanisms, supporting its traditional use and highlighting its potential for further pharmacological development.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01160"},"PeriodicalIF":2.5,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Burn Wound Healing and Anti-inflammatory Potential of Semi-synthetic Bergenia ciliata-loaded Carboxymethyl Cellulose Hydrogel: A Biochemical Perspective. 半合成纤毛草负载羧甲基纤维素水凝胶对烧伤创面愈合和抗炎潜力的评价：生化视角。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-18 DOI: 10.1002/cbdv.202500925

Anfah Riaz, Shaukat Ali, Muhammad Summer

{"title":"Evaluation of Burn Wound Healing and Anti-inflammatory Potential of Semi-synthetic Bergenia ciliata-loaded Carboxymethyl Cellulose Hydrogel: A Biochemical Perspective.","authors":"Anfah Riaz, Shaukat Ali, Muhammad Summer","doi":"10.1002/cbdv.202500925","DOIUrl":"https://doi.org/10.1002/cbdv.202500925","url":null,"abstract":"The present work evaluated the wound healing capacity of Bergenia ciliata (BC) loaded carboxymethyl cellulose (CMC) hydrogel and its various components in a mouse model. In comparison to treatment groups, CMC-BC nanoparticles (CMC-BCNPs) significantly promoted wound contraction in burn injuries. The levels of glutathione (5.0 ± 0.3 µmol/L), glutathione peroxidase (179.4 ± 7.8 U/L), superoxide dismutase (194.6 ± 4.0 U/mL), catalase (6.2 ± 0.4 mmol/mL), malondialdehyde (3.5 ± 0.2 mmol/L), tumor necrosis factor-α (19.8 ± 2.2 pg/mL), interleukin-6 (15.8 ± 1.5 pg/mL), and interleukin-8 (18.4 ± 1.9 pg/mL) were significantly restored in the CMC-BCNPs treatment group. Furthermore, the normal re-epithelialization, angiogenesis, and maturation of wounds in treatment groups supported the justification that CMC, coupled with BC extract and CMC-BC-based silver NPs, can operate synergistically to improve therapeutic effects. In carrageenan-induced paw edema, in the multiple treatment group, the inflammation inhibition was 38.17% at the fourth hour. Other treatment groups, BC 300 mg/kg, BC 200 mg/kg, and BCNPs-CMC, inhibition rates were 36.43%, 30.40%, and 24.97%, respectively. At the same time, BC-CMC and BC 100 mg/kg showed inhibition of 23.40% and 22.10%, respectively. In summary, BC 300 mg/kg shown the most anti-inflammatory effects compared to the other concentrations and combinations of BC. Conclusively, BC showed significant anti-inflammatory and wound healing effects, paving the way for mechanistic biomedical research.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00925"},"PeriodicalIF":2.5,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Essential Oils From Bougainvillea glabra Stem Barks and Leaves: Chemical Profile, Biological Activity, and Computational Approaches. 九重葛茎、皮和叶精油：化学特征、生物活性和计算方法。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-18 DOI: 10.1002/cbdv.202502210

Mai Phuong Thanh, Phan Hong Minh, Ty Viet Pham, Nguyen Thi Huong, Nguyen Xuan Ha, Ninh The Son

{"title":"Essential Oils From Bougainvillea glabra Stem Barks and Leaves: Chemical Profile, Biological Activity, and Computational Approaches.","authors":"Mai Phuong Thanh, Phan Hong Minh, Ty Viet Pham, Nguyen Thi Huong, Nguyen Xuan Ha, Ninh The Son","doi":"10.1002/cbdv.202502210","DOIUrl":"https://doi.org/10.1002/cbdv.202502210","url":null,"abstract":"This study first investigates the chemical composition and biological activities of essential oils extracted from the stem barks and leaves of Bougainvillea glabra Choisy cultivated in Vietnam. The gas chromatography-mass spectrometry (GC-MS) analysis revealed cis-phytol as the major compound, especially in the leaf essential oil (75.5%). Both essential oils exhibited notable cytotoxicity against HepG2 cells, with the stem bark oil showing stronger effects. The samples also displayed significant antioxidant activity, xanthine oxidase (XO) inhibition, nitric oxide (NO) suppression, and enzyme inhibitory properties against α-glucosidase, protein tyrosine phosphatase 1B (PTP1B), and acetylcholinesterase (AChE), with the leaf oil generally outperforming the stem bark oil. B. glabra showed anti-inflammation via the inhibition of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions. Especially, the studied oils (IC50 198.43-227.18 µg/mL) are better than the standard acarbose (IC50 241.76 µg/mL) against the α-glucosidase enzyme. Antimicrobial assays revealed moderate inhibition of two samples against both Gram (+) and Gram (-) bacteria, but limited antifungal activity. The findings were further supported by computational analyses. Molecular docking and toxicity prediction of the three major oil constituents, linalool, cis-phytol, and neophytadiene, revealed notable binding affinities to α-glucosidase and favorable safety profiles.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02210"},"PeriodicalIF":2.5,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis and Antitumor Evaluation of Novel Dehydroabietic Acid Derivatives Bearing an α,β-Unsaturated Ketone Moiety. 含有α，β-不饱和酮段的新型脱氢枞酸衍生物的设计、合成及抗肿瘤评价

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-16 DOI: 10.1002/cbdv.202501583

Zihan Fan, Xinyu Zhao, Meishan Li, Hengshan Wang, Rizhen Huang

引用次数: 0

New Bioactive Eudesmane-type Sesquiterpenoids From the Red Sea Soft Coral Nephthea sp. 红海软珊瑚中新的生物活性尤达斯曼型倍半萜类化合物。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-16 DOI: 10.1002/cbdv.202502473

Ahmed H Eissa, Helnan A Aboseada, Seif-Eldin N Ayyad

{"title":"New Bioactive Eudesmane-type Sesquiterpenoids From the Red Sea Soft Coral Nephthea sp.","authors":"Ahmed H Eissa, Helnan A Aboseada, Seif-Eldin N Ayyad","doi":"10.1002/cbdv.202502473","DOIUrl":"https://doi.org/10.1002/cbdv.202502473","url":null,"abstract":"Two previously unreported eudesmane-class sesquiterpenes, (4R*,5S*,6Z,10R*)-11-hydroperoxy-8-oxo-eudesm-6-en-5α-ol (1) and (4R*,5S*,6Z,10R*)-5-acetoxy-11-methoxy-8-oxo-eudesm-6-en (2), were obtained through fractionation of the CH2Cl2/MeOH (1:1) extract derived from the Red Sea-derived soft coral Nephthea sp., along with three known sesquiterpenes (3-5). The structural determination of the new compounds was achieved through comprehensive analysis of spectroscopic data, including one- and two-dimensional nuclear magnetic resonance techniques and high-resolution electrospray ionisation mass spectrometry measurements. The cytotoxic activities of the newly isolated compounds (1 and 2) were evaluated using the Sulforhodamine B assay against three human carcinoma cell lines: MCF-7, HT-29 and HepG2, with doxorubicin serving as the reference drug. Metabolite 2 showed moderate cytotoxicity towards MCF-7 and HT-29 cell lines, with IC50 values of 51.5 ± 2.1 and 64.1 ± 1.9 µM, respectively, and weak activity against HepG2 (IC50 = 71.3 ± 2.5 µM). In contrast, compound 1 displayed weak cytotoxic effects across all tested cell lines, with IC50 values of 72.8 ± 2.3 µM (MCF-7), 85.4 ± 2.7 µM (HT-29) and 95.6 ± 3.2 µM (HepG2). These findings contribute to the chemical and biological characterisation of Nephthea sp. metabolites and support further exploration of eudesmane-type sesquiterpenes as potential anticancer agents.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02473"},"PeriodicalIF":2.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Profile, Antioxidant, Anticholinesterase, and Antiproliferative Activities of Endemic Onosma discedens: In Vitro and In Silico Approaches. 地方性瘤病的植物化学特征、抗氧化、抗胆碱酯酶和抗增殖活性：体外和计算机方法。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-16 DOI: 10.1002/cbdv.202502147

Tugrul Cagri Akman, Samed Simsek, İrem Nisa Erken, Kübra Gizem Yildiztekin, Hayrunnisa Tasci, Halil İbrahim Türkoğlu, Esra Dilek

{"title":"Phytochemical Profile, Antioxidant, Anticholinesterase, and Antiproliferative Activities of Endemic Onosma discedens: In Vitro and In Silico Approaches.","authors":"Tugrul Cagri Akman, Samed Simsek, İrem Nisa Erken, Kübra Gizem Yildiztekin, Hayrunnisa Tasci, Halil İbrahim Türkoğlu, Esra Dilek","doi":"10.1002/cbdv.202502147","DOIUrl":"https://doi.org/10.1002/cbdv.202502147","url":null,"abstract":"This study presents the first comprehensive analysis of the phytochemical profile and biological activities of root and stalk extracts from endemic Onosma discedens Hausskn. ex Bornm. (OD). The extracts of OD were analyzed by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS), and 16 phenolics, including vanillic acid (2077.1332 µg/g extract in root) and hesperidin (1185.3621 µg/g extract in stalk), were detected. In antioxidant activity tests, DPPH• radical scavenging activity of root extract (IC50: 60.69 µg/mL) was found to be higher than stalk extract (IC50: 95.66 µg/mL), but both extracts showed lower activity than standard antioxidants. In antiproliferative activity assays, the OD extract exhibited low cytotoxicity against MCF7 cell lines, with an IC50 value exceeding 500 µg/mL. The stem extract was more effective on the butyrylcholinesterase (BChE) enzyme (IC50: 546.09 ± 0.533 µg/mL) than on the acetylcholinesterase (AChE) enzyme (IC50: 721.156 ± 0.410 µg/mL). When the plant is evaluated as a whole, it has a dual inhibitory effect on both cholinesterase enzymes. Molecular docking analyses confirmed the interactions of vanillic acid and hesperidin with target enzymes. As a result, it was revealed that OD, which has a rich structure in phenolic compounds and significant bioactivity due to its cholinesterase inhibitory effect, can be utilized to treat neurodegenerative illnesses like Alzheimer's.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02147"},"PeriodicalIF":2.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0