Chemistry & Biodiversity最新文献

{"title":"Antidiabetic, Antihyperlipidemic Activities of Gelatin Nanoparticles Encapsulated With Murraya koenigii (L.) Spreng. in High Fat Diet-Fed Streptozotocin-Induced Wistar Rats.","authors":"Akurange Sujeevi Dammadinna Wickramasinghe, Anoja Priyadarshani Attanayake, Pabasara Kalansuriya, Liyanage Dona Ashanthi Menuka Arawwawala","doi":"10.1002/cbdv.202402965","DOIUrl":"10.1002/cbdv.202402965","url":null,"abstract":"<p><p>Nanoencapsulation of herbal extracts is an emerging strategy in developing novel therapeutic agents to combat Type 2 diabetes mellitus. The present study aimed to investigate the sub-acute antidiabetic and antihyperlipidemic effects of aqueous ethanol 70% v/v extract of Murraya koenigii (L.) Spreng. (MAE) encapsulated gelatin nanoparticles (MGNP) using a high fat diet fed streptozotocin-induced Wistar rats with Type 2 diabetes mellitus. MGNP (10, 20, and 60 mg kg^-1) and free MAE (85, 255, and 765 mg kg^-1) were orally administered to rats for 28 days, biochemical and histopathological investigations were conducted. Rats treated with MGNP (therapeutic dose:20 mg kg^-1) showed significant (p < 0.05) decrease in glycated hemoglobin (by 61.7%, 16.3%), homeostatic model assessment (HOMA) of insulin resistance (by 64.7%, 49.0%), triglyceride (by 49.2%, 10.4%), very low density lipoprotein-cholesterol (by 49.4%, 10.4%), tumor necrosis factor-alpha (by 75.9%, 41.5%), malondialdehyde (by 67.5%, 27.5%), and increased HOMA of β-cell function (by 949.5%, 449.7%), leptin (by 283.3%, 177.0%), catalase (by 429.8%, 102.9%), and total antioxidant capacity (by 688.0%, 13.4%) compared to diabetic control rats and MAE, respectively, indicating profound antihyperglycemic, antihyperlipidemic, anti-inflammatory, and antioxidant activities. The biochemical findings were corroborated by ameliorating histopathological abnormalities in the pancreas, proving that MGNP is a novel drug lead in pharmaceutical applications.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202402965"},"PeriodicalIF":2.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfonamides as a Promising Scaffold in Drug Discovery: An Insightful Review on FDA-Approved Molecules, Synthesis Strategy, Medical Indication, and Their Binding Mode.","authors":"Ali Abbas Aslam, Mahmood Ahmed, Mohammed H Al Mughram, Mian Habib-Ur-Rahman Mahmood, Sehar Basheer, Riaz Hussain, Eisha Eiman, Mudassar Sanaullah, Hussain Raza, Ahmad Saeed, Muhammad Hassan, Dure Najaf Iqbal","doi":"10.1002/cbdv.202403434","DOIUrl":"10.1002/cbdv.202403434","url":null,"abstract":"<p><p>Sulfonamides have emerged as a versatile and promising scaffold in drug discovery, demonstrating various biological activities and therapeutic applications. Since the discovery of Prontosil in the 1930s, sulfonamide-containing compounds have evolved significantly, leading to numerous Food and Drug Administration (FDA)-approved drugs targeting multiple diseases. This review provides an insightful analysis of FDA-approved sulfonamide-containing molecules from 2011 to 2024, focusing on their synthesis strategies, medical indications, and binding modes. The review highlights the therapeutic potential of sulfonamides in treating viral infections, cancer, inflammatory diseases, ocular diseases, cardiovascular disorders, kidney and liver disorders, and more. The synthesis pathways of sulfonamides are meticulously detailed, showcasing the innovative chemical strategies employed to develop these therapeutic agents. The review also emphasizes the structural diversity of sulfonamide derivatives and their mechanisms of action, including carbonic anhydrase inhibition, Janus kinase (JAK)/signal transducer and activator of the transcription (STAT) pathway modulation, and protease inhibition, among others. This comprehensive review underscores the importance of sulfonamides in modern medicinal chemistry, offering valuable insights into their design, synthesis, and clinical applications. By bridging the gap between chemical synthesis and therapeutic efficacy, this review aims to inspire further research and development in the field, paving the way to discover novel sulfonamide-based drugs with enhanced efficacy and reduced side effects.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202403434"},"PeriodicalIF":2.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Synthetic Strategy and Field Testing Tomato Pinworm Pheromone in Armenia.","authors":"Nina G Hobosyan, Kristine V Balyan, Lusine A Movsisyan, Varduhi S Hovsepyan, Hmayak B Sargsyan, Haykanush R Pogosyan, Harutyun R Harutyunyan, Armine A Manvelyan, Margarit H Ghazaryan, Samvel S Asatryan, Hrant L Terlemezyan","doi":"10.1002/cbdv.202403455","DOIUrl":"10.1002/cbdv.202403455","url":null,"abstract":"<p><p>Two synthon C10 + C3 strategy syntheses of tomato pinworm sex pheromone- (E)-, (Z)-tridec-4-en-1-yl acetates- were illustrated. The iodinated dec-1-yn was successfully applied as a substrate in the synthesis of sex pheromone. The C10-component-1-iododec-1-yne was first obtained by the electrophilic iodination of dec-1-yne in the presence of cadmium (II) acetate. Additionally, the C3 component was produced from 2-(3-bromopropoxy) tetrahydro-2H-pyran by the Grignard reaction. The most important stage was the coupling of C10 and C3 components, and condensation in tetrahydrofuran in the presence of dilithium tetrachlorocuprate was carried out due to the great reactivity of the 1-iododec-1-yne. The dispensers were made based on the target sex pheromone and located in the traps. The active preparative forms were tested in field conditions in some regions of Armenia in 2024. Based on the field studies Keiferia lycopersicella belonging to the family Gelechiidae was recorded in Armenia (Armavir, Ararat, Tavush, and Kotayk regions) for the first time.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202403455"},"PeriodicalIF":2.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of the Chemical Constituents and Hypoglycemic Activities of Two Chinese Juhua Teas (Chrysanthemum morifolium Ramat. and Coreopsis tinctoria Nutt.).","authors":"Yiyi Ye, Hongbing Liu, Manman Xin, Yingwei Liu, Jun Tong, Jichao Liang, Lijuan Sun","doi":"10.1002/cbdv.202500008","DOIUrl":"https://doi.org/10.1002/cbdv.202500008","url":null,"abstract":"<p><p>Chrysanthemum morifolium Ramat. (CM) and Coreopsis tinctoria Nutt. (CT), known as \"Juhua\" in China, are frequently consumed as tea. However, comparative studies on their chemical composition and biological activity are lacking. This study analyzed the chemical constituents of CM and CT aqueous extracts using high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (HPLC-DAD-ESI-QTOF-MS) and assessed their hypoglycemic and antioxidant activities. Both extracts primarily contained flavonoids and phenolic acids; CM contained 35 flavonoids (27 flavones, 4 flavonols, 3 flavanones, and 1 flavanonol) and 14 caffeoylquinic acids (CQAs), while CT contained 41 flavonoids (3 flavones, 6 flavonols, 20 flavanones, 5 flavanonols, and 7 chalcones) and 12 CQAs. CT demonstrated significantly higher total phenolics and flavonoids-three times more phenolics and two times more flavonoids than CM. It showed greater α-glucosidase inhibition, glycosylation reduction, and 2-NBDG uptake enhancement compared to CM. Additionally, CT's antioxidant capacity was superior to that of CM. These findings indicate that while both CM and CT are rich in flavonoids and phenolic acids, their compositions differ significantly. The higher concentration of these compounds in CT contributes to its more pronounced hypoglycemic and antioxidative effects, providing valuable insights for the future use of Juhua in diabetes treatment.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202500008"},"PeriodicalIF":2.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Profiling, Bioactive Potential and In Silico Analysis of Kydia calycina Roxb. Leaf Extracts.","authors":"Nayan Kumar Sishu, Chinnadurai Immanuel Selvaraj","doi":"10.1002/cbdv.202403132","DOIUrl":"10.1002/cbdv.202403132","url":null,"abstract":"<p><p>Kydia calycina Roxb. has therapeutic properties, and it cures boils, skin infections, arthritis, ulcers, jaundice and lumbago. The leaf sample was extracted using methanol, ethanol and ethyl acetate. Phytochemical analyses, antioxidant, antibacterial, anti-inflammatory, antidiabetic and anticancer assays were performed. The effect of K. calycina leaf extract on the germination of radish and amaranth seeds was determined. The HRLC-MS analysis revealed that the ethanol, methanol and ethyl acetate extracts showed the presence of 46, 64 and 44 compounds, respectively. The ethanolic extract of K. calycina leaf exhibited the highest DPPH scavenging (IC₅₀ value = 28.37 ± 0.03 µg/mL), phosphomolybdenum reduction (IC₅₀ value = 62.11 ± 0.14 µg/mL), anti-inflammatory activity (IC₅₀ value = 60.38 ± 0.47 µg/mL), α-amylase inhibition (IC₅₀ value = 63.94 ± 0.55 µg/mL), α-glucosidase inhibition (IC₅₀ value = 25.54 ± 0.38 µg/mL) and antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus in comparison to the other extracts. The ethyl acetate extract showed cytotoxicity towards A549 cells with an IC₅₀ value of 22.06 ± 0.9 µg/mL. The germination percentage for radish and amaranth seeds were 63.33% ± 0.2% and 76.66% ± 0.1%, respectively. The in silico studies showed the binding affinity of the phytocompounds towards the protein targets for antibacterial, antidiabetic and anticancer activity.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202403132"},"PeriodicalIF":2.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry Combined With Network Pharmacology to Elucidate the Bioactive Ingredients and Potential Mechanism of Wu-Teng Decoction for Treatment of Rheumatoid Arthritis.","authors":"Wei Zou, Bangyong Wang, Xiaoqing Feng, Chunhua Lai, Qingang Tan","doi":"10.1002/cbdv.202403454","DOIUrl":"10.1002/cbdv.202403454","url":null,"abstract":"<p><p>Wu-Teng Decoction (WTD) is a significant in-hospital preparation widely used in clinical practice to treat rheumatoid arthritis (RA) in China, however, its active substances and underlying mechanisms remain unclear. In this study, the chemical constituents of WTD were analyzed using ultra-high-performance liquid chromatography-tandem mass spectrometry, identifying a total of 120 compounds, including flavonoids, phenylpropanoids, phenolic acids, alkaloids, etc. Subsequently, network pharmacology analyses revealed that 29 compounds were potential active compounds in WTD for the treatment of RA, as well as 48 core anti-RA targets, including tumor necrosis factor-α, V-Akt murine thymoma viral oncogene homolog 1, and albumin. Further analysis suggested that WTD treats RA via the phosphoinositide 3-kinase-Akt, mitogen-activated protein kinase, and Ras signaling pathways. Molecular docking analysis of the top five pivotal targets with the core active ingredients demonstrated suitable binding interactions at the active site of target proteins. The significant reduction of nitric oxide levels in lipopolysaccharides-induced RAW264.7 cells validated the anti-inflammation activity of WTD.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202403454"},"PeriodicalIF":2.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Pharmacology Combining Network Pharmacology to Discover the Mechanism of Total Flavonoids in Aronia melanocarpa Fruit for Acute Lung Injury.","authors":"Kairui Sheng, Jiancheng Li, YingJie Yang, Yu Zhang, Yang Ping, Jin Su, Lihong Wang","doi":"10.1002/cbdv.202403278","DOIUrl":"10.1002/cbdv.202403278","url":null,"abstract":"<p><p>In this study, we used in vitro antioxidant assay and in vivo anti-inflammatory assay to comprehensively evaluate the activity of total flavonoids of Aronia melanocarpa fruit (AMF) in the treatment of acute lung injury (ALI) and explored the mechanism of action of total flavonoids of AMF in the treatment of ALI based on the method of serum medicinal chemistry combined with network pharmacology. In the present study, 107.37 mg g^-1 alcoholic extract of total flavonoids was used for the determination of in vitro antioxidant activity by UV spectrophotometric method; the ALI model mice were induced by lipopolysaccharide (LPS), and the organ index of mice, the wet-to-dry ratio of lungs, and the histopathological sections of lungs were measured; the levels of inflammatory factors (interleukin-1β [IL-1β], TL-6, and tumor necrosis factor-α [TNF-α]) were determined in serum and alveolar lavage fluid of mice by ELISA; the composition of AMF total flavonoids and the migratory components of blood were analyzed on the basis of UHPLC-MS/MS. We analyzed the composition of AMF total flavonoids and the migratory components in blood based on UHPLC-MS/MS technology as well as analyzed the active compounds, targets and mechanism of action of AMF total flavonoids in the treatment of ALI through serum medicinal chemistry combined with network pharmacology. The in vitro antioxidant combined with in vivo anti-inflammatory assays showed that AMF total flavonoids exhibited excellent therapeutic efficacy for the treatment of ALI. A total of 31 flavonoids were identified by UHPLC-MS/MS, and 21 compounds were identified from the serum samples of mice after the administration of AMF total flavonoids, including 11 prototypical compositions and 10 metabolites; 11 blood-migratory prototypical compositions and relevant targets for ALI were collected by network pharmacology. Finally, 77 intersecting targets were obtained, including AKT1, interleukin-6 [IL-6], TNF, EGFR, and IL-1β. These overlapping targets mainly corresponded to quercetin, 5-hydroxy-3,3',4',6,7,8-hexamethoxyflavone, and kaempferol, which regulate inflammatory responses through the PI3K/AKT signaling pathway. The mechanism of action of total flavonoids from AMF fruits for the treatment of ALI provided a new way to utilize AMF as a new food resource and new ideas for the research of new drugs for the prevention and treatment of ALI.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202403278"},"PeriodicalIF":2.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piperine as Potential Anti-Inflammatory Agent: In-Silico Studies Along With In-Vitro Anti-Cathepsin B Activity, and Serum Protein Protection Validation.","authors":"Manishita R Sharma, Parveen K Sharma, Brij Mohan, Surendra P Bhatti, Anjaneyulu Bendi, Neera Raghav","doi":"10.1002/cbdv.202500144","DOIUrl":"10.1002/cbdv.202500144","url":null,"abstract":"<p><p>Piperine reported to have diverse pharmacological potentials has been screened towards a number of anti-inflammatory molecular targets such as Cox-2, interleukin-1β (IL-1β), IL-4, IL-13, matrix metallopeptidase-3 (MMP-3), MMP-8; in-silico using the various computational tools like variable nearest neighbour absorption, distribution, metabolism, excretion, and toxicity (vNN-ADMET), SWISS ADME, Spartan-14, iGemdock, and DS-Visualizer. The results when compared with commercial drugs exhibited parallel anti-inflammatory potential with ibuprofen and naproxen. In addition, we here report in-vitro anti-cathepsin B and serum protein-protecting activities. Complete inhibition of cathepsin B was observed at 200 µM of piperine and 250 µM for both indomethacin and naproxen, respectively. And, 100% anti-denaturation was observed at 10 µM of piperine, and 15 µM of indomethacin and naproxen. The results validated the anti-inflammatory potential of piperine, with both in silico and in vitro studies targeting previously unreported mechanisms.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202500144"},"PeriodicalIF":2.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pearl Millet: Nutritional composition, Phytochemical Profile and Functional Potential- A Comprehensive Review.","authors":"Ronak Tanwar, Anil Panghal, Anju Kumari, Navnidhi Chhikara","doi":"10.1002/cbdv.202402437","DOIUrl":"https://doi.org/10.1002/cbdv.202402437","url":null,"abstract":"<p><p>Climate change presents a growing challenge to global food systems, particularly in regions vulnerable to drought and water scarcity. This shows the urgent need to explore and promote climate-resilient crops that offer both resilience and high nutritional value. Pearl millet (Pennisetum glaucum), a drought-tolerant grain with ancient roots in Africa and Asia, presents a compelling solution for global food security amidst climate change. This review aims to highlight the unrevealed potential of Pennisetum glaucum as a sustainable and nutritious food source including its naturally gluten-free profile, high dietary fiber content surpassing rice, a lipid profile comparable to maize, and a superior essential amino acid profile compared to wheat and rye. The diverse functional properties of millets emphasizes low glycaemic index, potential role in weight management and mitigating the risk of chronic diseases like diabetes, aligning with contemporary health concerns.  By promoting its cultivation, processing, and consumption through research, policy support, and market development, we can contribute to building more resilient and equitable food systems while promoting dietary diversity and improved nutrition for growing population.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202402437"},"PeriodicalIF":2.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asptertides A-H, C₁₃-Polyketides From a Marine-Derived Aspergillus terreus.","authors":"Yue-Wei Xu, Zhi-Pu Yu, Xiang-Yu Liu, Ying Li, Chu-Hong Fang, Jian-Min Yue, Jin-Hai Yu, Chang-Yun Wang, Bin Zhou","doi":"10.1002/cbdv.202500494","DOIUrl":"10.1002/cbdv.202500494","url":null,"abstract":"<p><p>In the present study, 11 C₁₃-polyketides comprising a monocyclic skeleton of an aromatic (1-6 and 11) or a cyclohexanone moiety (7) and an oxygenated bicyclic nucleus (8-10) were isolated from a mutated strain of endophytic fungus Aspergillus terreus RA2905. Five pairs of enantiomers (2a/b-5a/b and 7a/b) were achieved by chiral-phase HPLC separation. The structures of previously unreported asptertides A-H (1-8) were determined by analysis of the spectroscopic data and electronic circular dichroism (ECD) calculations. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging bioassays revealed that some compounds showed moderate antioxidant effects, with IC₅₀ values ranging from 13.7 to 35.6 µM.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202500494"},"PeriodicalIF":2.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}