Chemistry & Biodiversity最新文献_第9页

A Comprehensive Review on Ferula oopoda (Boiss. and Buhse) Boiss.: Bioactive Compounds and Pharmacological Significance. 卵阿魏综述。和Buhse) Boiss。生物活性化合物及其药理意义。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71851

Muhammad Ali, Setya Widi Ayuning Permanasari, Shah Iram Niaz, Aizhamal Baiseitova, Abdul Bari Shah, Yuan Bin Cheng

{"title":"A Comprehensive Review on Ferula oopoda (Boiss. and Buhse) Boiss.: Bioactive Compounds and Pharmacological Significance.","authors":"Muhammad Ali, Setya Widi Ayuning Permanasari, Shah Iram Niaz, Aizhamal Baiseitova, Abdul Bari Shah, Yuan Bin Cheng","doi":"10.1002/cbdv.71851","DOIUrl":"10.1002/cbdv.71851","url":null,"abstract":"Ferula oopoda (Boiss. and Buhse) Boiss. is an ethnomedicinally important species widely used in Central and South Asia for the treatment of gastrointestinal, respiratory, neurological, and parasitic disorders. Despite its extensive traditional applications, comprehensive scientific evaluation of its pharmacological potential remains limited. This review systematically analyzes, for the first time, the available literature on the botany, phytochemical composition, ethnomedicinal uses, and pharmacological activities of F. oopoda, while highlighting current research gaps and future perspectives for drug discovery. To date, thirty-three secondary metabolites have been isolated from F. oopoda, including sesquiterpene lactones (STLs), sesquiterpenoids, monoterpene-phenyl esters, and phenolic acid glucosides. In addition, gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) analyses detected several low-molecular-weight constituents in essential oils and organic extracts. Both crude extracts and isolated compounds have displayed a broad spectrum of biological activities, including antibacterial, anti-plasmodial, antioxidant, anti-inflammatory, antimutagenic, and antiulcer effects. However, detailed mechanistic studies, pharmacokinetic investigations, and in vivo validations remain limited. Future research integrating structure-activity relationship studies and molecular target identification with omics-based approaches (e.g., metabolomics), in silico techniques such as molecular docking, and nano-drug delivery systems will be essential to advance its development into evidence-based therapeutic agents.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71851"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13684308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149230852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response Surface Optimization of Ultrasound-Assisted Deep Eutectic Solvent Extraction of Bioactive Polysaccharides From Sword Bean (Canavalia gladiata (Jacq.) DC.) Pods. 超声辅助深度共晶溶剂萃取剑豆生物活性多糖的响应面优化直流)。豆荚。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71766

Jieyu Xing, Linjing Zhang, Zhaoxuan Liang, Zheng Liu, Haiyun Chen, Xian Fu

{"title":"Response Surface Optimization of Ultrasound-Assisted Deep Eutectic Solvent Extraction of Bioactive Polysaccharides From Sword Bean (Canavalia gladiata (Jacq.) DC.) Pods.","authors":"Jieyu Xing, Linjing Zhang, Zhaoxuan Liang, Zheng Liu, Haiyun Chen, Xian Fu","doi":"10.1002/cbdv.71766","DOIUrl":"https://doi.org/10.1002/cbdv.71766","url":null,"abstract":"Safe and functional natural active ingredients are a research hotspot in early intervention studies of chronic diseases. This study focuses on a polysaccharide (CGPs‑1) from sword bean (Canavalia gladiata (Jacq.) DC.) pods. Its optimal ultrasound-assisted extraction conditions were achieved with choline chloride/oxalic acid DES (2:1), 34% water, 21 mL/g, 65°C, 29 min at 280 W; the actual yield (33.24%) was consistent with the predicted value (33.96%). CGPs‑1 was identified as a pyran‑type polysaccharide, comprising rhamnose (Rha), glucuronic acid (GlcA), and galacturonic acid (GalA) in a molar ratio of 1.08:1:1.78. CGPs‑1 had IC50 values of 0.157 mg/mL (α‑glucosidase), 0.083 mg/mL (α‑amylase), 31.18 mg/mL (DPPH radicals), and 2.264 mg/mL (ABTS radicals), inhibited LPS‑triggered inflammatory response and LPS‑mediated neurotoxicity in BV2 cells, and also suppressed MPTP-induced inflammatory response in zebrafish larvae. Results indicate that CGPs‑1 exhibits antioxidant, hypoglycemic, anti‑neuroinflammatory and neuroprotective potentials, providing preliminary experimental support for further research and the development of functional‑food‑related products derived from sword bean pods.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71766"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of 1,2,3-Triazole Derivatives of N,N-Dimethyltryptamine Isolated From Mimosa tenuiflora Root Bark: Antiplasmodial Activity In Silico and In Vitro. 含羞草根皮中N，N-二甲基色胺1,2,3-三唑衍生物的合成及其体外抗疟原虫活性研究

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71849

Renato Pinto de Sousa, William Cezar de Lima Silva, Caíque Lopes Duarte, Ana Claudia de Souza Pinto, Amanda Luisa da Fonseca, Fernanda Alice de Oliveira, Fernando de Pilla Varotti, Bruno Antônio Marinho Sanchez, Mahendra Rai, Maurício Pires de Moura do Amaral, Mariana Helena Chaves, João Sammy Nery de Souza, Warley de Souza Borges, Gerardo Magela Vieira Júnior

{"title":"Synthesis of 1,2,3-Triazole Derivatives of N,N-Dimethyltryptamine Isolated From Mimosa tenuiflora Root Bark: Antiplasmodial Activity In Silico and In Vitro.","authors":"Renato Pinto de Sousa, William Cezar de Lima Silva, Caíque Lopes Duarte, Ana Claudia de Souza Pinto, Amanda Luisa da Fonseca, Fernanda Alice de Oliveira, Fernando de Pilla Varotti, Bruno Antônio Marinho Sanchez, Mahendra Rai, Maurício Pires de Moura do Amaral, Mariana Helena Chaves, João Sammy Nery de Souza, Warley de Souza Borges, Gerardo Magela Vieira Júnior","doi":"10.1002/cbdv.71849","DOIUrl":"https://doi.org/10.1002/cbdv.71849","url":null,"abstract":"Malaria is a severe parasitic disease, with Plasmodium falciparum as one of the main etiological agents. The growing resistance to antimalarial drugs underscores the urgent need for the development of new therapeutic agents. This study describes the semisynthesis of eight new 1,4-disubstituted 1,2,3-triazole derivatives (3-10) from N,N-dimethyltryptamine (1), isolated from Mimosa tenuiflora. The derivatives were obtained through copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reactions and characterized by NMR and mass spectrometry. Compound 1 showed low in vitro activity against the W2 strain of P. falciparum (IC50 = 288.4 ± 28.53 µM), whereas compound 4 demonstrated promising activity (IC50 = 4.8 ± 0.32 µM), with higher selectivity toward the TOV-21G cell line. In in silico studies, all derivatives showed more favorable binding energy values compared to compound 1, particularly compound 7 (-9.8 kcal/mol) relative to the crystallographic ligand (-6.9 kcal/mol). These results highlight the importance of structural modifications in the development of new antimalarial agents.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71849"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wuguchong Bioactive Peptides Promote Wound Healing via Hedgehog Pathway‑Mediated Fibroblast Modulation. 五骨冲生物活性肽通过刺猬通路介导的成纤维细胞调节促进伤口愈合。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71671

Kun Li, Yunpu Sun, Lijie Pang, Tiantian Gao, Yunpeng Diao, Shuyuan Fan

{"title":"Wuguchong Bioactive Peptides Promote Wound Healing via Hedgehog Pathway‑Mediated Fibroblast Modulation.","authors":"Kun Li, Yunpu Sun, Lijie Pang, Tiantian Gao, Yunpeng Diao, Shuyuan Fan","doi":"10.1002/cbdv.71671","DOIUrl":"10.1002/cbdv.71671","url":null,"abstract":"The skin undertakes multiple critical physiological functions, including barrier protection and thermoregulation. However, chronic nonhealing ulcers have emerged as a major clinical challenge. In wound repair, skin healing is a highly coordinated, time-sequential process wherein fibroblasts-key dermal cells-play irreplaceable roles in proliferation, migration, differentiation, and extracellular matrix (ECM) synthesis. When external environmental factors induce fibroblast dysfunction, this can lead to impaired epithelialization, thereby resulting in persistent wound nonclosure, which may represent a key mechanism underlying the pathogenesis of this condition. Yet current clinical treatments (debridement, anti-infection, negative pressure drainage, and growth factors) fail to resolve this, with high recurrence and poorly understood molecular mechanisms. To this end, we identified in this study a low‑molecular‑weight bioactive peptide (< 10 kDa) originating from Wuguchong (JY), which is capable of specifically regulating fibroblasts in the wound microenvironment. By modulating the Hedgehog (Hh) signaling pathway, this peptide restores fibroblast function, thereby promoting wound healing and effectively ameliorating the challenge of impaired wound repair. This study not only offers promise for the development of new drugs for treating ulcers, but also provides novel insights and strategies for cell‑based therapies targeting other types of wound healing.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71671"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health Beneficial Chemo Diversity and Antioxidant Potential of Philonotis revoluta Bosch & Sande Lac (A-Moss). 对健康有益的化学多样性和博世和桑迪湖（A-Moss）的抗氧化潜力。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71838

Sheela Parihar, G S Deora, Jagrati Agrawal, Sarswati, Monika K Shekhawat, Sandhya Deora

{"title":"Health Beneficial Chemo Diversity and Antioxidant Potential of Philonotis revoluta Bosch & Sande Lac (A-Moss).","authors":"Sheela Parihar, G S Deora, Jagrati Agrawal, Sarswati, Monika K Shekhawat, Sandhya Deora","doi":"10.1002/cbdv.71838","DOIUrl":"10.1002/cbdv.71838","url":null,"abstract":"The current study evaluated the phytochemical composition and antioxidant potential of Philonotis revoluta using methanolic, ethyl acetate, and n-hexane extracts through analytical techniques. Preliminary qualitative analysis revealed secondary metabolites such as flavonoids, phenols, terpenoids, glycosides, alkaloids, and saponins. UV-visible analysis supported the occurrence of compounds, and FTIR analysis confirmed the presence of diverse functional groups. GC-MS identified various bioactive compounds, including ergost-5-en-3-ol, stigmasta-5,22-dien-3-ol, and other secondary metabolites. Quantitative analysis showed that the methanol extract had the highest total phenolic (21.97 ± 0.06 mg GAE/g) and total flavonoid content (38.97 ± 0.04 mg QE/g) compared to the ethyl acetate and n-hexane extracts. Antioxidant assays (DPPH, ABTS, and FRAP) showed a solvent polarity-dependent effect, with methanol showing stronger scavenging activity (IC50 229 ± 1.036 µg/mL ABTS; 568 ± 3.963 µg/mL DPPH), followed by the ethyl acetate and hexane extracts, while ethyl acetate (41.42 ± 0.000 µg FeSO4 eq/mL) showed comparatively higher ferric-reducing power than methanol and hexane extracts. All extracts showed significant antioxidant activity (p < 0.05). The study suggested P. revoluta contains numerous biologically active phytochemicals with promising antioxidant activity; therefore, there remains scope for this study to explore the therapeutic potential for the development of new drugs.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13687913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, and Antifungal Structure-Activity Relationship of Hydrazide Derivatives Containing a Cyclopropyl Group Against Phytopathogenic Fungi. 含环丙基酰肼衍生物的设计、合成及其对植物病原真菌的抑菌构效关系

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71820

Shanshan Yang, Xinyuan Wang, Bixi Yin, Weiting Yan, Lei Wang, Yunying Sha, Lizhong Wang, Zhuyun Liu

{"title":"Design, Synthesis, and Antifungal Structure-Activity Relationship of Hydrazide Derivatives Containing a Cyclopropyl Group Against Phytopathogenic Fungi.","authors":"Shanshan Yang, Xinyuan Wang, Bixi Yin, Weiting Yan, Lei Wang, Yunying Sha, Lizhong Wang, Zhuyun Liu","doi":"10.1002/cbdv.71820","DOIUrl":"https://doi.org/10.1002/cbdv.71820","url":null,"abstract":"To discover novel antifungal agents with unique scaffolds for crop protection, a series of 23 hydrazide derivatives containing a cyclopropyl group, including 14 new chemical entities, were designed, synthesized, and evaluated for their antifungal activity against eight phytopathogenic fungi. The in vitro bioassay results at 50 µg/mL revealed that most target compounds exhibited moderate to excellent antifungal activities. Notably, three compounds (4, 6, 7) displayed the most potent broad-spectrum activity with inhibition rates of 95.0%-100.0% against all eight tested fungi. Their EC50 values were below 10 µg/mL against most fungi. SEM analysis revealed that the parent compound 1 caused pronounced morphological alterations in A. alternata mycelia, including shrinkage, collapse, and irregular distortion, providing a preliminary indication of the cellular effect of the series. Molecular docking of compound 1 with succinate dehydrogenase (SDH) generated a plausible binding model, suggesting SDH as a potential target candidate for this series, pending direct enzymatic validation. SAR analysis demonstrated that the phenyl ring was consistently associated with high activity, and para-substitution with halogen atoms is favorable for enhancing antifungal activity. These findings suggest that cyclopropyl-containing hydrazide derivatives, particularly compounds 4, 6, and 7, represent promising lead candidates for the development of novel antifungal agents.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Thiochroman-4-One Derivatives Bearing a Sulfonyl Hydrazone Moiety: Synthesis, Bioactivity, Molecular Simulation, and Drug-Likeness Evaluation. 新型磺酰腙基硫代铬-4- 1衍生物：合成、生物活性、分子模拟和药物相似性评价。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71884

Pei Li, Wenming Pan, Tiantian Zhuang, Xiang Wang

{"title":"Novel Thiochroman-4-One Derivatives Bearing a Sulfonyl Hydrazone Moiety: Synthesis, Bioactivity, Molecular Simulation, and Drug-Likeness Evaluation.","authors":"Pei Li, Wenming Pan, Tiantian Zhuang, Xiang Wang","doi":"10.1002/cbdv.71884","DOIUrl":"https://doi.org/10.1002/cbdv.71884","url":null,"abstract":"Herein, a series of novel thiochroman-4-one derivatives bearing sulfonyl hydrazone moiety were rationally designed and synthesized via molecular hybridization strategy. The sulfonyl hydrazone pharmacophore with excellent hydrogen-bonding interaction ability was first introduced into the thiochroman-4-one parent skeleton to construct dual-active functional molecules, aiming to achieve synergistic α-glucosidase inhibition and antioxidant activity for antidiabetic therapy. All target compounds were structurally characterized by 1H NMR, 1 3C NMR, and HRMS. Bioactivity results showed that multiple derivatives exhibited excellent α-glucosidase inhibitory activity and antioxidant capacity, among which compound 5k displayed the optimal comprehensive pharmacological performance with IC50 value of 4.57 µg/mL against α-glucosidase, which was significantly superior to the positive control acarbose (237.48 µg/mL). Molecular docking and molecular dynamics (MD) simulation verified that the optimal compound 5k could stably bind to the active pocket of α-glucosidase through multiple hydrogen bonds and hydrophobic interactions, with lower binding energy and better complex stability. Drug-likeness evaluation demonstrated that all synthesized derivatives complied with Lipinski's rule of five and had favorable pharmacokinetic properties. This work provides a novel structural scaffold for the development of high-efficiency antioxidant, α-glucosidase, and antibacterial inhibitors, and demonstrates its potential as a lead compound for pharmaceutical and agrochemical development.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LC-MS-Based Annotation of Bioactive Metabolites From Streptomyces fimicarius-ghR Against the Common Scab Pathogen Using Molecular Networking. 基于lc - ms的真菌链霉菌ghr抗常见结痂病原体生物活性代谢物的分子网络注释

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71772

Maryam Ramezani-Moghadam, Sareh Baghaee-Ravari, Abolghasem Danesh, Mohsen Taghavi, Karel Nesměrák, Martin Štícha, Maryam Akaberi

{"title":"LC-MS-Based Annotation of Bioactive Metabolites From Streptomyces fimicarius-ghR Against the Common Scab Pathogen Using Molecular Networking.","authors":"Maryam Ramezani-Moghadam, Sareh Baghaee-Ravari, Abolghasem Danesh, Mohsen Taghavi, Karel Nesměrák, Martin Štícha, Maryam Akaberi","doi":"10.1002/cbdv.71772","DOIUrl":"https://doi.org/10.1002/cbdv.71772","url":null,"abstract":"Natural products have long served as a cornerstone for the discovery of antimicrobial drugs. Members of the genus Streptomyces are particularly noteworthy for their ability to produce structurally diverse metabolites, occupy diverse ecological niches, and enhance soil nutrient availability in agricultural systems. They also represent a major reservoir of antibiotics with strong antagonistic activity against plant pathogens. In an ongoing study, Streptomyces fimicarius-ghR demonstrated antimicrobial activity, particularly against the potato common scab pathogen (Streptomyces sp.). To elucidate the chemical basis underlying its biocontrol efficacy, we employed a computational metabolomics-based bioprospecting strategy to characterize the chemical diversity of potential anti-scab metabolites in the antagonist's fermentation broth. The ethyl acetate (EtOAc) extract of S. fimicarius-ghR exhibited inhibitory activity against Streptomyces sp. FG1, with a minimum inhibitory concentration (MIC) of 0.3 mg/mL. The EtOAc extract was subjected to liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (LC-QTOF-ESI-MS/MS), followed by molecular networking-based data analysis. This approach enabled the annotation of 13 metabolites, including multiple isomers of mycosubtilins as well as both linear and cyclic surfactins. These findings suggest that lipopeptide antibiotics, particularly surfactins and mycosubtilins produced by S. fimicarius-ghR, may play a central role in suppressing the potato common scab pathogen.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bombyx mori-Hosted Cordyceps militaris Polysaccharides: Structural Characterization and Antibacterial Activity of Native and Sulfated Derivatives. 桑家蚕寄生的蛹虫草多糖：结构表征和天然和硫酸盐衍生物的抗菌活性。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71798

Jingchun Yang, Jiani Cheng, Gaoyang Li, Wenpu Shi, Yaqi Liu, Tingyu Luo, Lixue Zheng

{"title":"Bombyx mori-Hosted Cordyceps militaris Polysaccharides: Structural Characterization and Antibacterial Activity of Native and Sulfated Derivatives.","authors":"Jingchun Yang, Jiani Cheng, Gaoyang Li, Wenpu Shi, Yaqi Liu, Tingyu Luo, Lixue Zheng","doi":"10.1002/cbdv.71798","DOIUrl":"https://doi.org/10.1002/cbdv.71798","url":null,"abstract":"Polysaccharides from Bombyx mori-hosted Cordyceps militaris are abundant but exhibit limited bioactivity, necessitating exploration of sulfated derivatives. In this study, crude polysaccharides (Bm-CMP) were extracted and further sulfated to obtain four derivatives (Bm-sCMP-1∼4). Physicochemical and structural analyses indicated that sulfation significantly modified the characteristics of Bm-CMP, notably reducing the molecular weight (Mw) and particle size while enhancing the negative surface charge and altering the monosaccharide profile. All sulfated derivatives exerted enhanced inhibitory effects against Escherichia coli and Bacillus subtilis, which were closely dependent on the degree of substitution (DS), sulfate content, and negative charge density. Notably, Bm-sCMP-2, with a moderate DS, displayed the optimal antibacterial efficacy. Collectively, this work demonstrates that sulfation is a feasible strategy to valorize polysaccharides from B. mori-hosted C. militaris, transforming them into promising candidates for novel antibacterial agents, although their in vivo efficacy and safety require further validation.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71798"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13628141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemistry, Pharmacological Potential, and Future Prospects of Abietane-Type Diterpenoids From Salvia rosmarinus. 迷迭香中abietane型二萜的植物化学、药理潜力及前景展望

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71841

Rida Siddiqui, Vipin Singh, Kapil Dev

{"title":"Phytochemistry, Pharmacological Potential, and Future Prospects of Abietane-Type Diterpenoids From Salvia rosmarinus.","authors":"Rida Siddiqui, Vipin Singh, Kapil Dev","doi":"10.1002/cbdv.71841","DOIUrl":"10.1002/cbdv.71841","url":null,"abstract":"Salvia rosmarinus, formerly known as Rosmarinus officinalis, is a medicinal plant known as one of the sources of abietane-type diterpenoids. The largest family of chemical constituents from the Salvia genus is abietanes and rearranged abietanes. Since 1976, 365 of the 545 known diterpenoids have been recognized as abietane diterpenoids. Carnosic acid, carnosol, rosmanol, epirosmanol, and their derivatives are among the bioactive abietanes that have gained much attention because of the wide spectrum of pharmacological activities. This review presents information on the distribution, isolation, biosynthesis, structural variation, degradation, semi-synthetic strategies, pharmacokinetics, and bioactivities of abietane-type diterpenoids from S. rosmarinus. Recent developments in eco-friendly extraction techniques, namely, supercritical fluid extraction, microwave-assisted extraction, ultrasound-assisted extraction, and pressurized liquid extraction, are also described in this review. The biosynthetic pathway from geranylgeranyl diphosphate to main diterpenoids, such as carnosic acid and carnosol, is also presented. Moreover, newly isolated compounds, structure-activity relationships, and antioxidant, antimicrobial, anti-inflammatory, neuroprotective, and anticancer activities are included. Moreover, the pharmacokinetics of abietane diterpenoids isolated from S. rosmarinus and their medicinal applications are also covered in this review.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71841"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0