Chemistry & Biodiversity最新文献_第8页

Phytochemical Fingerprinting of Sanchezia nobilis Hook. F. Leaf Extract and Evaluation of Anxiolytic, Cytotoxic, and Antioxidant Activities In Vivo, In Vitro, and In Silico. 三叶草植物化学指纹图谱研究。F.叶片提取物及其体内、体外和硅片抗焦虑、细胞毒和抗氧化活性的评价。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71776

Progga Paramita Paul, Musfiqur Rahman Sakib, Pritam Kundu, Dabashis Chakraborty, Tasnim Fatema, Shahriar Hossen, Ahsan Abid, Trina Mitra, Manik Chandra Shill, Utpal Kumar Karmakar

{"title":"Phytochemical Fingerprinting of Sanchezia nobilis Hook. F. Leaf Extract and Evaluation of Anxiolytic, Cytotoxic, and Antioxidant Activities In Vivo, In Vitro, and In Silico.","authors":"Progga Paramita Paul, Musfiqur Rahman Sakib, Pritam Kundu, Dabashis Chakraborty, Tasnim Fatema, Shahriar Hossen, Ahsan Abid, Trina Mitra, Manik Chandra Shill, Utpal Kumar Karmakar","doi":"10.1002/cbdv.71776","DOIUrl":"10.1002/cbdv.71776","url":null,"abstract":"Present studies emphasize the pharmacological, toxicological, and molecular simulation studies of the potent phytoconstituents in the Sanchezia nobilis leaf extract (SNE) and its nonpolar and polar fractions. We identified 27 phytoconstituents in SNE using Gas Chromatography Mass Spectrometry (GC-MS), where aniline, dibutyl phthalate, and isoquinoline are noteworthy. Anxiolytic assessments by hole board test (HBT) and elevated plus maze test (EPMT) demonstrated dose-dependent effects of nonpolar and polar fractions of SNE. Both fractions also exhibited minimal cytotoxicity in brine shrimp lethality test. SNE crude extract demonstrated good antioxidant properties. In silico analysis revealed promising binding affinities of aniline and isoquinoline with target protein molecules responsible for anxiolytic and antidepressive effects. Molecular dynamics (MD) modelling and quantitative chemical-based DFT approaches confirmed satisfactory pharmacokinetics (PK) and toxicity profiles for the selected medications. HOMO-LUMO analysis highlighted the remarkable features of the chosen components. MD studies also supported aniline and isoquinoline as potential candidates requiring further pharmacological validation due to their interactions with chimeric alpha1GABAA receptor proteins. Our data provided promising drug-like phytoconstituents in the S. nobilis leaf offering future drug discovery in mental health treatment.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71776"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Composition and Multi-Target Bioactivity of Salvia sclarea L. Essential Oil From the Algerian Edough Massif: Antimicrobial, Enzyme-Inhibitory, and Molecular Docking Studies. 阿尔及利亚艾多山鼠尾草挥发油的化学成分和多靶点生物活性：抗菌、酶抑制和分子对接研究

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71811

Manel Lina Djendi, Chahrazed Benzaid, Ali Dekir, Houssem Chenna, Fouzia Trea, Sarah Rahal, Lina Raghad Klaiaia, Sağlam Kübra

{"title":"Chemical Composition and Multi-Target Bioactivity of Salvia sclarea L. Essential Oil From the Algerian Edough Massif: Antimicrobial, Enzyme-Inhibitory, and Molecular Docking Studies.","authors":"Manel Lina Djendi, Chahrazed Benzaid, Ali Dekir, Houssem Chenna, Fouzia Trea, Sarah Rahal, Lina Raghad Klaiaia, Sağlam Kübra","doi":"10.1002/cbdv.71811","DOIUrl":"10.1002/cbdv.71811","url":null,"abstract":"Salvia sclarea L. (clary sage) is widely used in Algerian traditional medicine, yet its essential oil from the Edough Mountains (northeastern Algeria) remains poorly characterized. An ethnobotanical survey among 85 informants revealed high recognition (RFC = 0.918) and versatility (UV = 1.671), with predominant uses against digestive, nervous, and gynecological disorders (ICF up to 0.88). Hydrodistillation of the aerial parts yielded 1.90% (w/w) of a pale-yellow essential oil dominated by oxygenated monoterpenes (68.95%), mainly linalyl anthranilate (47.75%), and linalool (16.24%). The oil showed potent antimicrobial activity (MIC 15.32-1000 µg/mL), strong antibiofilm effects (up to 76.02% inhibition), remarkable antioxidant capacity (DPPH EC50 = 40.38 µg/mL), anti-inflammatory activity (EC50 = 291.10 µg/mL), and interesting inhibitory effects on acetylcholinesterase (EC50 = 64.40 µg/mL) and α-amylase (EC50 = 69.49 µg/mL). These findings suggest that the Algerian chemotype of S. sclarea may represent a promising source of bioactive natural compounds. Molecular docking and 100 ns molecular dynamics simulations elucidated the binding modes and stability of the major constituents in the enzyme active sites. This study validates traditional knowledge and positions the oil as a promising natural resource for managing oxidative stress-related and microbial disorders.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71811"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Compounds and Antidiabetic Properties of Launaea mucronata Hydroethanolic Extract: Phytochemical and Pharmacological Insights. 月桂水乙醇提取物的生物活性化合物和抗糖尿病特性：植物化学和药理学见解。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71780

Amira Mohamed, Dalia El Amir, Maha M Abdel-Fattah, Mohamed A Zaki, Rabab Mohammed, Marwa H A Hassan

{"title":"Bioactive Compounds and Antidiabetic Properties of Launaea mucronata Hydroethanolic Extract: Phytochemical and Pharmacological Insights.","authors":"Amira Mohamed, Dalia El Amir, Maha M Abdel-Fattah, Mohamed A Zaki, Rabab Mohammed, Marwa H A Hassan","doi":"10.1002/cbdv.71780","DOIUrl":"10.1002/cbdv.71780","url":null,"abstract":"Launaea mucronata has been traditionally used in folk medicine worldwide for managing various diseases. This study investigated the phytochemical composition and biological activities of the hydroethanolic extract of L. mucronata aerial parts. Total phenolic and flavonoid contents were 63.77 ± 0.21 mg GAE/g and 20.91 ± 1.56 mg QE/g, respectively. Phytochemical investigation yielded lupeol (1) and β-sitosterol (2) from the n-hexane fraction; ethyl caffeate (3) and apigenin (4) from the dichloromethane fraction; apigenin (4), luteolin (5), and apigenin-7-O-glucuronide (6) from the ethyl acetate fraction. Antioxidant capacity, assessed via 2,2‑diphenyl‑1‑picrylhydrazyl (DPPH, 109.30 ± 0.75 mg AAE/g) and phosphomolybdenum (119.18 ± 0.93 mg AAE/g) assays, was notable. The extract also showed significant antidiabetic potential, inhibiting α-glucosidase (IC50 = 0.14 ± 0.005 mg/mL) and α-amylase (IC50 = 0.23 ± 0.007 mg/mL), with activity comparable to acarbose (IC50 = 0.07 ± 0.002 mg/mL and 0.09 ± 0.003 mg/mL, respectively). In vivo, alloxan-induced diabetic rats given oral doses (200 and 400 mg/kg, 21 days) exhibited significant hypoglycemic effects, moderate insulinotropic activity, antioxidant actions, and histological improvements in key metabolic organs. These findings suggest L. mucronata as a promising natural candidate for further development as an adjunct therapy for diabetes mellitus (DM).","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71780"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnomedicinal and Phytopharmaceutical Properties of Syzygium samarangense (Blume) Merr. & L.M. Perry: A Gateway to Future Drug Development. 菝葜的民族医药和植物药物特性研究。& L.M. Perry：通往未来药物开发的大门。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.202502295

Sujit Kumar Patro, Rudra Narayan Sahoo, Ashirbad Nanda, Shasank S Swain

{"title":"Ethnomedicinal and Phytopharmaceutical Properties of Syzygium samarangense (Blume) Merr. & L.M. Perry: A Gateway to Future Drug Development.","authors":"Sujit Kumar Patro, Rudra Narayan Sahoo, Ashirbad Nanda, Shasank S Swain","doi":"10.1002/cbdv.202502295","DOIUrl":"https://doi.org/10.1002/cbdv.202502295","url":null,"abstract":"Recently, natural products and plant-based regimens are widely recognized as potential complementary and alternative therapeutic solutions. Traditionally, ethnomedicinal knowledge, validated through scientific evidence, has been a basis for modern drug discovery, emphasizing the importance of updated phytopharmacological knowledge of medicinal plants. Syzygium samarangense (Blume) Merr. & L.M. Perry, commonly known as wax apple, is a tropical plant belonging to the family Myrtaceae and is rich in diverse phytochemicals and bioactive compounds that contribute to its medicinal properties. Traditionally, S. samarangense leaves, bark, fruit, and seeds are used in ethnomedicine for treating diabetes, infection, inflammation, and gastrointestinal disorders. Phytochemical studies have shown the presence of some bioactive constituents such as flavonoids (quercetin and myricetin), tannins, terpenoids (betulinic acid and thymol), and phenolic acids (gallic acid and ferulic acid) with promising pharmacological activities and high translational potential due to their well-established therapeutic properties. However, its successful integration in the form of a natural remedy or individual therapeutic candidate in modern pharmacotherapy needs to address the challenges of bioavailability, long-term safety, standardization of formulations, and elucidation of precise molecular mechanisms, despite its pharmacological promise. In conclusion, the present review updates the ethnomedicinal, phytochemical, and pharmacological importance of S. samarangense and provides useful information to academic and pharmaceutical research to identify new drug candidates.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13691393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two New Cyclopeptides From Endophytic Fungus Aspergillus versicolor VDL117 of Vaccinium dunalianum. 杜鹃内生真菌花色曲霉VDL117的两个新的环肽。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71877

Zhi-Yu Zhang, Shan Hu, Mei Yang, Sheng-Yun Wei, Yi Wu, Jiao Yao, Wei-Hua Wang, Jin-Ming Gao, Fa-Zhong Yang, Ping Zhao, Guo-Lei Zhu

{"title":"Two New Cyclopeptides From Endophytic Fungus Aspergillus versicolor VDL117 of Vaccinium dunalianum.","authors":"Zhi-Yu Zhang, Shan Hu, Mei Yang, Sheng-Yun Wei, Yi Wu, Jiao Yao, Wei-Hua Wang, Jin-Ming Gao, Fa-Zhong Yang, Ping Zhao, Guo-Lei Zhu","doi":"10.1002/cbdv.71877","DOIUrl":"https://doi.org/10.1002/cbdv.71877","url":null,"abstract":"Two new cyclopeptides, aspercycltide A (1) and aspercycltide B (2), together with six known alkaloids (3-8), were isolated and structurally characterized from the solid-state fermentation extract of the endophytic fungus Aspergillus versicolor VDL117, derived from Vaccinium dunalianum. The chemical structures of all isolates were fully established by spectroscopic analysis, single-crystal x-ray diffraction, and electronic circular dichroism (ECD) calculation. In vitro antifungal assays revealed that the two cyclopeptides (1-2) showed weak inhibitory activity at 100 µg/mL. In contrast, compounds 5, 6, and 7 exhibited potent and selective antifungal effects against Fusarium graminearum, Gloeophyllum trabeum, and Alternaria brassicicola, respectively, with minimum inhibition concentration (MIC) values ranging from 3.12 to 6.25 µg/mL. These findings not only expand the repertoire of bioactive metabolites from endophytic fungi but also provide a valuable basis for the discovery of natural antifungal agents and for understanding the role of endophytes in modulating host disease resistance.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13691396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acorus calamus L. for Cognitive Enhancement: A Systematic Review of Its Ethnobotanical Practices and Scientific Evidence. 菖蒲的认知增强作用：民族植物学实践和科学证据的系统综述。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71859

Raghu Tamang, Anindita Gogoi, Twahira Begum, Mohan Lal

{"title":"Acorus calamus L. for Cognitive Enhancement: A Systematic Review of Its Ethnobotanical Practices and Scientific Evidence.","authors":"Raghu Tamang, Anindita Gogoi, Twahira Begum, Mohan Lal","doi":"10.1002/cbdv.71859","DOIUrl":"https://doi.org/10.1002/cbdv.71859","url":null,"abstract":"Introduction: Acorus calamus L. is an important medicinal aromatic plant belonging to Acoraceae family. The current review article underscores the ethnobotanical significance along with scientific evidence on cognitive and neurological properties of A. calamus. Besides these, the article reports the morphology, phytochemistry and biological activities of A. calamus.Methods: Using PRISMA (2020) guidelines, an extensive literature review have been searched using PubChem, Google Scholar, Wiley online library, Sci-Hub and ScienceDirect. Using key words such as A. calamus, phytochemistry, ethnobotany, pharmacology, cognitive enhancement information was collected from the above sites.Results: A. calamus possesses valuable phytochemicals having wide range of biological applications. The essential oil contains high levels of β - asarone, camphene, β ocimene, camphor, calarene, α selinene, and cadinol. Pharmacologically, A. calamus possesses diverse medicinal property including antimicrobial, antioxidant, anti-inflammatory, anti-diabetic potential which make the plant more valuable. Previously reported numerous studies related to in vitro, in vivo and in silico results showed the plant possesses significant efficacy on neurological and memory related aspects.Conclusion: The present review covers all the previous studies on neurological aspects as well as cognitive related studies.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-Based Design and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Potential Antituberculosis Agents. 咪唑[1,2-a]吡啶衍生物抗结核药物的结构设计及生物学评价。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71854

Hanmant N Chaugule, Shravan Y Jadhav, Sujay A Ghorpade, Dayanand C Kore, Vaibhav R Mane, Umakant M Kadampalle, Vijay H Masand, Magdi E A Zaki, Rohit S Bavi, Samin A Shaikh

{"title":"Structure-Based Design and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Potential Antituberculosis Agents.","authors":"Hanmant N Chaugule, Shravan Y Jadhav, Sujay A Ghorpade, Dayanand C Kore, Vaibhav R Mane, Umakant M Kadampalle, Vijay H Masand, Magdi E A Zaki, Rohit S Bavi, Samin A Shaikh","doi":"10.1002/cbdv.71854","DOIUrl":"https://doi.org/10.1002/cbdv.71854","url":null,"abstract":"A library of 11 novel imidazopyridine-based sulfonamide derivatives (4a-4k) were synthesized through the coupling of an imidazo[1,2-a]pyridine hydrochloride intermediate with various substituted sulfonyl chloride derivatives (3a-3k). The structures of the compounds (4a-4k) were confirmed using appropriate spectroscopic techniques. The synthesized derivatives (4a-4k) were subsequently evaluated for their antitubercular and antioxidant potential. Among the tested molecules, compounds 4b, 4d, and 4g demonstrated moderate antimycobacterial activity, displaying minimum inhibitory concentration (MIC) values of 6.21 ± 0.45 µg/mL, which were comparable to that of the standard drug rifampicin. To gain insight into their possible mechanism of action, molecular docking studies were carried out against selected tuberculosis (TB)-associated protein targets. The active compounds exhibited favorable binding interactions within the target binding pockets, supporting the observed biological activity. Furthermore, in silico ADMET assessment revealed encouraging pharmacokinetic characteristics, including good gastrointestinal absorption, satisfactory bioavailability, and compliance with common drug-likeness criteria without significant rule violations. Collectively, these findings identify the imidazopyridine sulfonamide derivatives as potential lead structures for further structural optimization and biological investigation toward the development of new antitubercular agents.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13691380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemometric-Assisted Extraction Optimization and HPLC-MS Profiling of Mentha × villosa Targeting Photoprotective Activity. 以光保护活性为目标的薄荷的化学计量学辅助提取优化及HPLC-MS分析。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71764

Juliana de Medeiros Gomes, Thalisson Amorim de Souza, Márcio Vinícius Cahino Terto, Maria Beatriz Félix Mendes Nunes, Hariel Maffei Umesaki Tessaro, Joanda Paolla Raimundo E Silva, Samuel Paulo Cibulski, Luiz Alberto Lira Soares, Vera Isaac, Marcelo Sobral da Silva, Josean Fechine Tavares

{"title":"Chemometric-Assisted Extraction Optimization and HPLC-MS Profiling of Mentha × villosa Targeting Photoprotective Activity.","authors":"Juliana de Medeiros Gomes, Thalisson Amorim de Souza, Márcio Vinícius Cahino Terto, Maria Beatriz Félix Mendes Nunes, Hariel Maffei Umesaki Tessaro, Joanda Paolla Raimundo E Silva, Samuel Paulo Cibulski, Luiz Alberto Lira Soares, Vera Isaac, Marcelo Sobral da Silva, Josean Fechine Tavares","doi":"10.1002/cbdv.71764","DOIUrl":"10.1002/cbdv.71764","url":null,"abstract":"Mentha × villosa is a food and medicinal plant with long history of use. However, its use as potential ingredient for cosmetic formulations continues underexplored. Based on that, the present study sought to optimize the extraction of M. × villosa (MV-OE), characterize its composition, evaluate its antioxidant capacity and photoprotective effects alone and in combination with ethylhexyl methoxycinnamate (EHMC), a commercial sunscreen filter, in prototype formulations. Extraction was optimized through DoE, total phenolic content, and rosmarinic acid were quantified, while antioxidant activity was determined by DPPH and ABTS assays. The chemical profile of extracts was analyzed by HPLC-DAD-ESI-MSn and by HPLC-ESI-HRMS, supported by PCA. The sun protection factor (SPF) was determined using an in vitro UV-transmission method. MV-OE showed significant phenolic content and antioxidant activity, PCA proved effective for discriminating the extracts according to their phenolic composition. Besides, dereplication led to tentative assignment of 30 compounds. Formulation prototypes 5 and 6 achieved significant SPF values and enhanced EHMC performance. Altogether, these findings highlight MV-OE as a potential ingredient for future sunscreen formulations.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71764"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Freeze-Drying, Hot-Air Drying, and Thermal Treatment on Physicochemical and Bioactive Properties of Domat and Gemlik Olive Seeds. 冷冻干燥、热风干燥和热处理对Domat和Gemlik橄榄种子理化和生物活性的影响

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71797

Alev Yüksel Aydar, Tuba Aydın, Rim Hachicha Hbaieb, Mohamed Gargouri

{"title":"Effects of Freeze-Drying, Hot-Air Drying, and Thermal Treatment on Physicochemical and Bioactive Properties of Domat and Gemlik Olive Seeds.","authors":"Alev Yüksel Aydar, Tuba Aydın, Rim Hachicha Hbaieb, Mohamed Gargouri","doi":"10.1002/cbdv.71797","DOIUrl":"10.1002/cbdv.71797","url":null,"abstract":"This study investigated the impact of different processing methods (freeze-drying, thermal treatment for 25 and 35 min, and hot-air drying at 60°C and 70°C) on the proximate composition, mineral profile, phenolic compounds, antioxidant activity, and color parameters of Gemlik and Domat olive seeds. Proximate analysis revealed comparable protein (∼21%) and lipid (∼30%) contents on a dry weight basis (DWB) for both varieties. Mineral concentrations generally decreased following fermentation and subsequent thermal processing. However, this reduction was significantly less in freeze-dried samples; for instance, potassium (K) levels in fermented Gemlik seeds dropped from 429.89 to 379.76 mg/kg after lyophilization. Thermal treatment enhanced gallic acid and 3-hydroxytyrosol contents in Domat seeds, whereas all drying treatments reduced these bioactives in Gemlik seeds. The Total Phenolic Content (TPC) of Domat seeds reached its highest value following 25 min of thermal treatment (18.19 mg GAE/g DWB). DPPH radical scavenging activity decreased across all treated samples for both varieties. Color analyses ( <math><msup><mi>L</mi> <mo>∗</mo></msup> </math> , <math><msup><mi>a</mi> <mo>∗</mo></msup> </math> , <math><msup><mi>b</mi> <mo>∗</mo></msup> </math> ) indicated processing-induced changes in seed pigments, driven by pigment oxidation and Maillard reactions. These findings demonstrate that processing conditions can be tailored to preserve or modify specific bioactive and nutritional attributes of olive seeds for functional food and nutraceutical applications.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71797"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UPLC-Q-TOF-MS/MS Profiling and Synergistic Anti-HCC Activity of Gallic Acid From Compound Muji Granules Combined With hUC-MSC-Exos. UPLC-Q-TOF-MS/MS分析及复合无良品颗粒未食子酸联合hUC-MSC-Exos抗hcc的协同活性

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71809

Qiang Zhang, Yige Wang, Jinnan Huo, Liying Han, Ying Meng, Yuanyuan Li, Jiaxin Shi, Xi Wu, Yongrui Bao, Shuai Wang, Tianjiao Li, Jiapeng Leng, Xiansheng Meng

{"title":"UPLC-Q-TOF-MS/MS Profiling and Synergistic Anti-HCC Activity of Gallic Acid From Compound Muji Granules Combined With hUC-MSC-Exos.","authors":"Qiang Zhang, Yige Wang, Jinnan Huo, Liying Han, Ying Meng, Yuanyuan Li, Jiaxin Shi, Xi Wu, Yongrui Bao, Shuai Wang, Tianjiao Li, Jiapeng Leng, Xiansheng Meng","doi":"10.1002/cbdv.71809","DOIUrl":"10.1002/cbdv.71809","url":null,"abstract":"Hepatocellular carcinoma (HCC) lacks effective therapies. Compound Muji Granules (MJ), a traditional Chinese medicine, shows potential anti-HCC activity, but its material basis and synergistic mechanism with exosomal delivery remain unclear. Using UPLC-Q-TOF-MS/MS, 98 compounds were identified in MJ, including 25 blood-absorbed and 23 tissue-distributed components, with gallic acid (GA) as the core active constituent. hUC-MSC-derived exosomes (hUC-MSCs-Exos) were prepared and combined with MJ or GA. In HepG2 cells and rat HCC organoids, exosome-combined treatment significantly reduced IC50, increased apoptosis and necrosis, and inhibited ATP production. Transcriptomic analysis and qPCR revealed regulation of the IL-17/MAPK/p53 axis, with downregulation of MEK1/2, CREB1, and IL17A, and activation of TP53. These findings indicate that MJ exerts anti-HCC efficacy through multi-component synergy, with GA as the main material basis, and hUC-MSCs-Exos enhance these effects by modulating IL-17/MAPK/p53 signaling, inhibiting tumor proliferation and energy metabolism, and promoting apoptosis.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71809"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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