Thi Phuong Le, Thuy Linh Nguyen, Bich Ngan Truong, Marc Litaudon, Thi Mai Huong Doan, Van Cuong Pham
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New Alkaloid and Sesquiterpenoid From the Leaves of Cinnamomum bejolghota.
From the leave of Cinnamomum bejolghota (Buch.- Ham. ex Nees) Sweet, one new alkaloid, 3,6-dimethoxy-9H-pyrido[3,4-b]indole (1) and one new aromadendrane sesquiterpenoid, 4α,10α-dihydroxyaromadendrane-13-oic acid (2) along with seven known compounds, 4β,10α-dihydroxyaromadendrane (3), litseachromolaevane A (4), curcumin (5), pisumionoside (6), quercetin-3-O-α-L-rhamnopyranoside (7), rutin (8), and kaemperol 3-O-neohesperidoside (9) were isolated and structurally determined. Their chemical structures were elucidated through comprehensive spectroscopic analyses, including high-resolution electrospray ionization mass spectrometry, one- and two-dimensional nuclear magnetic resonance, and by comparison with the literature data. Compounds 1-9 were evaluated for their cytotoxic activities against four human cancer cell lines (KB, MCF-7, HepG-2, and SK-LU1), however, only compound 8 displayed weak inhibitory activity on HepG2, A549 cancer cell lines with 50% inhibitory concentration (IC50) values of 97.8 and 68.8 µM, respectively and moderate inhibitory activity on MCF7 cancer cell line with an IC50 value of 49.7 µM.
期刊介绍：
Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level.
Since 2017, Chemistry & Biodiversity is published in an online-only format.
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