三种未被报道的抗氧化合穗叶片中α-葡萄糖苷酶和一氧化氮抑制活性的化合物。

IF 2.5 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-10-22 DOI:10.1002/cbdv.202501820

Do Thi Trang, Nguyen Viet Dung, Ngo Anh Bang, Vu Kim Thu, Le Thi Thuy Hang, Pham Hai Yen, Bui Huu Tai, Phan Van Kiem

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引用次数: 0

摘要

从鸢尾叶中分离到3个已知化合物，分别为2α，3β,20α，23-四羟基-no -30-urs-12-en-28-oic acid 28-O-β-d-glucopyranoside (1), 2α,3β,6β，23-四羟基齐oleea -11,13(18)-dien-28-oic acid(2)和4,6-二羟基-3-甲基-2- o -β-d-glucopyranosylbenzophenone(3)，以及11个已知化合物（4-14）。分离得到的化合物通过HR-ESI-MS和NMR谱进行了表征。化合物1、2、6和7对脂多糖（LPS）激活的小鼠巨噬细胞RAW264.7细胞的NO生成有显著抑制作用，IC50值分别为16.3、14.9、25.5和24.7µM。化合物9 ~ 12的α-葡萄糖苷酶潜力最大，IC50值为23.6 ~ 162.0µM。

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Three Previously Undescribed Compounds Isolated From the Leaves of Syzygium antisepticum With Their α-Glucosidase and Nitric Oxide Inhibitory Activity.

Three previously undescribed compounds, 2α,3β,20α,23-tetrahydroxy-nor-30-urs-12-en-28-oic acid 28-O-β-d-glucopyranoside (1), 2α,3β,6β,23-tetrahydroxyoleana-11,13(18)-dien-28-oic acid (2), and 4,6-dihydroxy-3-methyl-2-O-β-d-glucopyranosylbenzophenone (3), together with 11 known compounds (4-14) are isolated from the leaves of Syzygium antisepticum. The isolated compounds are characterized via HR-ESI-MS and NMR spectra. Compounds 1, 2, 6, and 7 exhibited significant inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells with IC₅₀ values of 16.3, 14.9, 25.5, and 24.7 µM, respectively. In addition, compounds 9-12 displayed the most potential α-glucosidase with IC₅₀ values ranging from 23.6 to 162.0 µM.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.