Biotechnological Potential of Seaweeds from Bahia, Brazil: Metabolomic insights, Photoprotection and Antioxidant Activity.

IF 2.5 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-10-15 DOI:10.1002/cbdv.202502708

Keila Almeida Santana, Isadora de Jesus da Silva, Victor Pena Ribeiro, José Marcos de Castro Nunes, Hosana Maria Debonsi, Ian Castro-Gamboa, Lorena Rigo Gaspar, Gustavo Souza Dos Santos, Aníbal de Freitas Santos Júnior

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引用次数: 0

Abstract

Seaweeds have wide biotechnological applications. This study evaluated the chemical profile, photoprotective, and antioxidant potential of Padina sp., Caulerpa sertularioides, and Solieria filiformis collected in Bahia, Brazil. Chemical characterization by gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (¹H NMR) confirmed fucosterol in Padina sp., β-sitosterol in C. sertularioides, and cholesterol in S. filiformis alongside fatty acids and aromatic metabolites; multivariate analyses supported species-specific chemical patterns. The extracts exhibited ultraviolet (UV) absorption, in specific the UVA range, and were nonirritant in the Organization for Economic Co-operation and Development (OECD) Test Guideline (TG) 491 assay. In human keratinocytes (HaCaT), C. sertularioides reduced UV-induced reactive oxygen species (ROS) by 75%, whereas Padina sp. and S. filiformis achieved 42% reduction. Conversely, extracts exhibited photodegradation in the UV region and phototoxic potential in the OECD TG 432 (3T3 neutral red uptake, NRU) assay. Because these trials used complex crude extracts, future studies should optimize the extraction process, fractionate bioactive-rich fractions, and isolate key compounds. These results highlight Brazilian algae as promising sources of new compounds and serve as a starting point for further investigations.

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巴西巴伊亚海藻的生物技术潜力：代谢组学见解、光保护和抗氧化活性。

海藻具有广泛的生物技术应用。本研究评价了采自巴西巴伊亚的Padina sp.， Caulerpa sertularioides和Solieria filiformis的化学特征、光防护和抗氧化潜力。通过气相色谱-质谱联用（GC-MS）和质子核磁共振（1H NMR）的化学表征，证实了Padina sp.中的focusterol， C. sertularioides中的β-谷甾醇，S. filiformis中的胆固醇以及脂肪酸和芳香代谢物；多变量分析支持物种特有的化学模式。在经济合作与发展组织（OECD）测试指南（TG） 491中，提取物具有紫外线（UV）吸收，特别是UVA范围内，并且无刺激性。在人角质形成细胞（HaCaT）中，C. sertularioides减少了75%的紫外线诱导的活性氧（ROS），而Padina sp.和S. filiformis则减少了42%。相反，提取物在UV区表现出光降解，在OECD TG 432 （3T3中性红色摄取，NRU）试验中表现出光毒性。由于这些试验使用了复杂的粗提取物，未来的研究应该优化提取工艺，提取富含生物活性的部分，并分离出关键化合物。这些结果突出了巴西藻类作为新化合物的有希望的来源，并作为进一步研究的起点。

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.