Chemistry & Biodiversity最新文献

{"title":"Design, Synthesis, and Insecticidal Activities of Imidazo[4,5-b]Pyridine Compounds Containing Amino Fragment.","authors":"Yunfeng Yao, Xinlin Li, Liqi Zhou, Jiyong Liu, Wenzhou Zhong, Minhua Liu","doi":"10.1002/cbdv.202500514","DOIUrl":"https://doi.org/10.1002/cbdv.202500514","url":null,"abstract":"<p><p>In order to develop new insecticides to solve the problem of pests, a series of imidazo[4,5-b]pyridine compounds containing amino fragments were synthesized and characterized by proton nuclear magnetic resonance (¹H NMR), carbon-13 NMR (¹³C NMR), and high-resolution mass spectrometry. The preliminary bioassay result indicated that most of the synthesized compounds exhibited excellent insecticidal activities against Nilaparvate lugens and Mythimna separata. Especially, 5-(ethylsulfonyl)-6-(3-methyl-6-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl)-N-(4-methylbenzyl)pyridin-2-amine (8n) exhibited 46.85 % mortality against N. lugens at 5 mg/L, better than Oxazosulfyl (0.00 % at 5 mg/L). Meanwhile, 5-(ethylsulfonyl)-6-(3-methyl-6-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl)-3-phenylpyridin-2-amine (10a) exhibited 100.00 % mortality against M. separata and Plutella xylostella at 1 mg/L, better than Oxazosulfyl against M. separata (0.00 % at 1 mg/L) and P. xylostella (96.67 % at 1 mg/L). Further, the preliminary structure-activity relationship was discussed. The work demonstrated that the prepared compounds containing amino fragments imidazo[4,5-b]pyridin can supply certain hints by structure optimization for the development of new insecticides.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00514"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Essence of Nature Can be the Simplest (4)-Adenine: Powerful Reserve for Extracellular Fenton Chemistry.","authors":"Qunfu Wu, Jiao Zhou, Donglou Wang, Xuemei Niu","doi":"10.1002/cbdv.202500941","DOIUrl":"https://doi.org/10.1002/cbdv.202500941","url":null,"abstract":"<p><p>Adenine has long been recognized for its critical roles in cellular metabolism and the storage of genetic information. However, the mechanism by which ATP, derived from adenine, outperforms nucleotides formed from other nucleobases as the primary energy currency remains unclear. In this study, we demonstrate that metabolism of all nucleobases produces hydrogen peroxide (H₂O₂), which serves as a key substrate for extracellular Fenton chemistry, a cellular energy mechanism that facilitates the increase of environmental temperature and the degradation of organic matter. Among the nucleobases, adenine metabolism generates the highest H₂O₂ levels, followed by guanine. Using thermophilic fungi as a model, we found that compared with the mutant without the extracellular Fenton reactions, wild-type strains with the extracellular Fenton chemistry showed downregulation of NTP synthesis and upregulation of nucleoside triphosphate degradation, resulting in H₂O₂ production. The function of nucleosides as crucial reserves for the extracellular Fenton reactions of organisms may offer insights into potential and natural functions of stop codons, poly(A) tails in RNA biosynthesis, junk DNA in the genome, tumor recurrence after chemotherapy or radiotherapy, shortening of telomerase genes with each cell division and the differentiation of long-lived keratinocyte stem cells with a high nucleus-to-cytoplasm ratio into short-lived enucleated keratinocytes.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00941"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects of Curcuminoids and Silymarin, Individually and in Combination, in Patients With Hepatic Impairment.","authors":"Eman M Elgendy, Walid A El Sherbiny, Amal G Sedki, Heba H Gaber","doi":"10.1002/cbdv.202403340","DOIUrl":"https://doi.org/10.1002/cbdv.202403340","url":null,"abstract":"<p><p>This research explores the medicinal potential of curcuminoids (CMNs) from turmeric and silymarin (SIL) from milk thistle for treating liver diseases. The study examines these compounds' individual and synergistic effects on liver dysfunction patients, focusing on their antioxidant, antimicrobial, and anticancer properties. A 4-week clinical trial involving 15 participants diagnosed with nonalcoholic fatty liver disease (NAFLD) was conducted to evaluate the therapeutic benefits of these compounds. Participants were chosen based on specific health criteria, enhancing the research's real-world applicability and instilling confidence in the practicality of the findings. Results indicated considerable antioxidant properties, antimicrobial effectiveness against pathogens like Staphylococcus aureus and Escherichia coli, and anticancer potential against liver and colorectal cancers. Significant improvements in liver enzyme indicators and serum lipid levels were observed. These findings suggest that CMNs and SIL, particularly in combination, may serve as effective natural treatments for liver dysfunction, offering a promising alternative for enhancing liver health in affected individuals.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e03340"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and Variability Analysis of Volatile Metabolites From Acer saccharum Leaves From Québec Region.","authors":"Jean-Christophe Séguin, Chelsea Mahannah, Normand Voyer","doi":"10.1002/cbdv.202501201","DOIUrl":"https://doi.org/10.1002/cbdv.202501201","url":null,"abstract":"<p><p>Volatile secondary metabolites in plants can serve as valuable biomarkers for the plant's health, stress response, and pest or disease detection. We have investigated the volatilome of Acer saccharum (sugar maple) leaves using two complementary extraction techniques: headspace-solid phase micro-extraction coupled with gas chromatography-mass spectrometry (HS-SPME-GC-MS) and hydrodistillation followed by gas chromatography with flame ionization and mass spectrometry detection. HS-SPME-GC-MS revealed variability in green leaf volatiles and terpenoids associated with tree diameter and maturity level, with (E)-hex-2-enal and (Z)-hex-3-enyl acetate as the major compounds. The abundance of certain compounds in HS-SPME-GC-MS spectra correlates closely with the tree diameter and is notably different between harvesting sites. Hydrodistillation allowed us to observe and identify 147 volatile compounds and a broad range of metabolites, including fatty acid derivatives and monoterpenoids, but demonstrated low extraction yields. Correlations between volatile profiles and tree traits suggest such compounds may serve as health and stress biomarkers. Our results suggest that volatile compound analysis may be useful for monitoring sugar maple health and provide a foundation for developing in vivo diagnostic tools to detect afflictions before physical symptoms arise.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01201"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marine Fungi-Derived Compounds as Promising KRas Localization Blockers: Structural Insights Into PDE6δ Inhibition.","authors":"Perwez Alam, Nikhil Kirtipal, Pradeep Sharma, Ali Akhtar, Mohammed Faiz Arshad","doi":"10.1002/cbdv.202500079","DOIUrl":"https://doi.org/10.1002/cbdv.202500079","url":null,"abstract":"<p><p>Cancer, often driven by genetic mutations like KRas activation, is a leading global cause of mortality. This study identified potential inhibitors of PDE6δ, a key chaperone required for KRas membrane localization, from marine fungi-derived compounds. Through molecular docking, molecular dynamics (MD) simulations, MMGBSA free energy calculations, and free energy landscape (FEL) analyses, three promising compounds were identified: CMNPD29003, CMNPD9449, and CMNPD30443. Among these, CMNPD29003 exhibited the highest stability, with RMSD values stabilizing between 1 and 2 Å during 500-ns MD simulations, reflecting strong and consistent binding. CMNPD9449 showed moderate stability (RMSD 1-3 Å with slight end-phase increases), whereas CMNPD30443 displayed weaker binding, with significant fluctuations (RMSD 2-6 Å). Despite stable binding (RMSD 1.5-2 Å), the control compound violated Lipinski's molecular weight rules and had poor solubility. MMGBSA calculations revealed CMNPD29003 as the most promising candidate, with a binding free energy of -106.35 ± 22.59 kcal/mol, supported by strong van der Waals and non-polar solvation contributions. CMNPD9449 showed a binding energy of -91.78 ± 11.03 kcal/mol, benefiting from favorable electrostatic interactions. FEL analysis confirmed CMNPD29003's consistent low-energy states. These findings suggest CMNPD29003 and CMNPD9449 as promising PDE6δ inhibitors, warranting further experimental validation for KRas-driven cancer therapies.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00079"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Chemometric Analysis With Acute Toxicity Tests of Zebrafish and Network Pharmacology for Comparison of Different Species: Rhubarb as an Example.","authors":"Wei Chen, Yu Yin, Fanghao Zhang, Bingyu Hao, Ying Liang, Huijie Zhang, Meng Wang, Yi Liu, Xiaoliang Ren","doi":"10.1002/cbdv.202501000","DOIUrl":"https://doi.org/10.1002/cbdv.202501000","url":null,"abstract":"<p><p>This study systematically evaluated the quality variations of Rheum spp. from different botanical origins through an integrated approach combining chemical characterization and biological validation. Chemometric analysis of chromatographic profiles effectively categorized the samples into two distinct groups, successfully differentiating Rheum tanguticum Maxim. ex Balf. from Rheum officinale Baill., and Rheum palmatum L., though the latter two species showed overlapping chemical characteristics. In the zebrafish acute toxicity test, the half-death rate of R. tanguticum was much lower than that of R. officinale and R. palmatum, further indicating that the classification was reasonable and reliable. Based on chemometrics and toxicity test results of zebrafish, four components of sennoside B, sennoside A, aloe-emodin 8-O-glucoside, and chrysophanol were selected as potential toxicity markers of rhubarb. Our findings suggest that rhubarb-induced hepatotoxicity likely results from multicomponent/multi-target synergistic interactions, particularly through modulation of PI3K-AKT/mTOR signaling, matrix remodeling, and stress response modulation. Molecular docking confirmed differential binding affinities, with chrysophanol and aloe-emodin 8-O-glucoside demonstrating strong target engagement. This integrated approach not only establishes a reliable quality assessment protocol for rhubarb species differentiation but also provides mechanistic insights into the complex toxicological profile of these medicinal plants, advancing our understanding of their pharmacotoxicological characteristics.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01000"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Compounds From Rosa canina L. Roots With Anti-Collagenase, Anti-Tyrosinase, and Antioxidant Activities: In Vitro and In Silico Approaches.","authors":"Tuğba Subaş, Ufuk Özgen, Şeyda Kanbolat, Merve Badem, Uğur Uzuner, Gonca Özdemir, Şule Zeytineli, Şeyma Altunışık, Halide Cangul, Özgür Eminağaoğlu","doi":"10.1002/cbdv.202500357","DOIUrl":"https://doi.org/10.1002/cbdv.202500357","url":null,"abstract":"<p><p>The study aimed to investigate the anti-aging, skin-whitening, and antioxidant capacities of the extracts and constituents from the roots of Rosa canina L. by anti-collagenase, anti-tyrosinase activity, ferric-reducing antioxidant power (FRAP), cupric-reducing antioxidant capacity (CUPRAC) assays, and the Folin-Ciocalteu method (for the extracts). Enzyme inhibitory activities, pharmacokinetics, and drug-likeness properties of the compounds were evaluated in silico. According to the results of activity studies, the ethyl acetate subextract exhibited the highest anti-tyrosinase activity, and the remaining aqueous subextract demonstrated the highest anti-collagenase activity. The isolation studies led to the purification of euscaphic acid (1), tormentic acid (2), kaji-ichigoside F1 (3), rosamultin (4), 2-oxopomolic acid (5), and (+)-catechin (6) for the first time from the roots of this plant. Isolated compounds exhibited anti-collagenase and anti-tyrosinase activities. The extracts and (+)-catechin had higher antioxidant capacities than other compounds. R. canina roots and their compounds can be included in dermocosmetic products after further studies.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00357"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing the Inhibitory Potential of Halogenated Symmetrical Formamidine Against MAO-A and MAO-B: Structural Elucidation, Molecular Dynamic Simulation and DFT Computational Studies.","authors":"Segun D Oladipo, Robert C Luckay, Samuel O Olalekan, Abosede A Badeji, Tunde L Yusuf, Adesola A Adeleke, Nonkosi Matinise","doi":"10.1002/cbdv.202500886","DOIUrl":"https://doi.org/10.1002/cbdv.202500886","url":null,"abstract":"<p><p>A halogenated symmetrical formamidine, N,N'-bis(3-chloro-4-fluorophenyl)formamidine (FCF) was synthesized by the condensation reaction between triethyl orthoformate and 3-chloro-4-fluoroaniline in 1:2 ratio. The compound FCF was characterized by FT-IR, mass, NMR (¹H and ¹³C) spectroscopic techniques and the purity was confirmed by elemental analysis. Crystal structural elucidation of FCF showed that it conformed to an E-anti-molecular isomer. In the crystal packing system of FCF, there exists N─H⋯N hydrogen bonding intermolecular interactions between the azomethine nitrogen (N-azomethine) and amine hydrogen (H-amine) atoms of neighboring molecules resulting in the formation of dimers with an R <math> <semantics><mfrac><mn>2</mn> <mn>2</mn></mfrac> <annotation>$frac{2}{2}$</annotation></semantics> </math> 8 graph set motif. Hirshfeld surface analysis unraveled that, H⋯H and Cl⋯H intermolecular contacts contributed equally and the most with each of them contributing 14.6% in crystal packing. The geometrical and electronic properties of FCF were investigated using DFT/B3LYP/6-311++G(d,p) basis sets. Mulliken and MESP analyses identified reactive sites, while FMO studies revealed a HOMO-LUMO gap (4.62 eV) indicative of intermediate reactivity and stability. Molecular docking and molecular dynamics simulations (MDS) were performed to evaluate the inhibitory potential of FCF against monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B), both are protein targets for managing Parkinson's disease. Docking studies revealed that FCF exhibited superior binding affinity towards both MAO-A and MAO-B compared to the reference drugs (harmine and rasagiline) as reflected in its more negative docking scores. MDS analysis was conducted over 100 ns and we found out that FCF demonstrated superior inhibitory potential against MAO-A and MAO-B compared to the reference drugs, as indicated by its stronger binding free energies (-38.78 ± 2.62 kcal mol^-1 for MAO-A and -34.15 ± 3.29 kcal mol^-1 for MAO-B) relative to harmine (-32.43 ± 2.26 kcal mol^-1) and rasagiline (-32.44 ± 2.65 kcal mol^-1). Furthermore, MDS analysis also confirmed the stability of FCF-protein complexes, with lower RMSD values suggesting greater structural stability. In addition, pharmacokinetic analysis revealed that FCF possesses favorable drug-like properties, including high gastrointestinal absorption, blood-brain barrier permeability, and a nontoxic profile, reinforcing its potential as a promising therapeutic agent for targeting neurodegenerative disorders such as Parkinson's disease.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00886"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Rosane and Podocarpane Diterpenoids From the Whole Plant of Jatropha curcas L.","authors":"Zhong-Dan Liang, Yan-Ling Tang, Chao-Jun Li, Yan-Fang Li, Muhammad Aurang Zeb, Xue-Wen Wu, Qi Li, Bo Li, Xiao-Li Li, Xing-Jie Zhang, Wei-Lie Xiao","doi":"10.1002/cbdv.202500956","DOIUrl":"https://doi.org/10.1002/cbdv.202500956","url":null,"abstract":"<p><p>One previously undescribed rosane diterpenoid (1) and 13 known ones (2-14) were isolated from the whole plant of Jatropha curcas L. The relative configuration 1 was determined by NMR calculation combined with DP4+ probability analysis, and its absolute configuration (AC) was further determined by ECD calculation. The final structure was further confirmed by single crystal x-ray diffraction. The biological testing revealed that compounds 5 and 14 possessed inhibitory effects on NLRP3 inflammasome with IC₅₀ values of 8.1 ± 0.3 and 9.7 ± 0.4 µM. Further investigation exhibited that compound 5 has an obvious effect on inhibiting pyroptosis.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00956"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Analysis of Hedysarum nitidum: Identification Phytochemical Contents, Antioxidant Potential, Antimicrobial Properties, Cytotoxic Effects, and Enzyme Inhibition Activities.","authors":"Nuray Baltürk, Merve Badem, Seyda Kanbolat, Sercan Yıldırım, Tuğba Mazlum Şen, Gözde Bozdal, Can Özgür Yalçın, Ali Kandemir, Nuriye Korkmaz, Sengul Alpay Karaoglu, Rezzan Aliyazicioglu","doi":"10.1002/cbdv.202500992","DOIUrl":"https://doi.org/10.1002/cbdv.202500992","url":null,"abstract":"<p><p>Hedysarum species play a crucial agronomic role due to their high feed quality and ability to enhance soil fertility through nitrogen fixation. Traditionally, they have been used in medicine to boost energy, support the immune system, and benefit the peripheral nervous system. However, the biological activity and phytochemical composition of Hedysarum nitidum remain unexplored. This study aimed to evaluate the bioactivity of methanol (HNM) and water (HNW) extracts from the aerial parts of H. nitidum. Antioxidant (total polyphenol and flavonoid contents, 2,2-diphenyl-2-picrylhydrazyl hydrate [DPPH], ferric-reducing antioxidant power [FRAP], Cu (II) ion reducing antioxidant capacity [CUPRAC]), antimicrobial, cytotoxic, and enzyme inhibitory (tyrosinase, cholinesterase, α-glucosidase, α-amylase) activities were assessed. Phytochemical and essential oil compositions were analyzed using high-performance liquid chromatography (HPLC) and gas chromatography-mass spectroscophy (GC-MS). HPLC identified p-hydroxybenzoic acid, caffeic acid, and 2-hydroxycinnamic acid, whereas GC-MS detected n-octanal, hexahydrofarnesyl acetone, humulene epoxide-II, α-terpineol, and eicosane. HNW and HNM exhibited strong antioxidant activity and enzyme inhibition, suggesting potential applications in hyperpigmentation, diabetes, and Alzheimer's treatment. HNM showed selective antibacterial activity against Gram-positive bacteria, whereas neither extract exhibited cytotoxicity against A549 cells. These findings highlight H. nitidum as a promising candidate for therapeutic applications.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e00992"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}