Chemistry & Biodiversity最新文献_第4页

Detection of the Hepatotoxins, Carboxyparquin and Parquin, in Cestrum, Sessea, and Vestia Species (Solanaceae). 茄科三种植物中肝毒素羧基Parquin和Parquin的检测。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71744

Stephen T Lee, Michael H Nee, Daniel G Ubiali, Franklin Riet-Correa, Mizael Machado, Daniel Cook

{"title":"Detection of the Hepatotoxins, Carboxyparquin and Parquin, in Cestrum, Sessea, and Vestia Species (Solanaceae).","authors":"Stephen T Lee, Michael H Nee, Daniel G Ubiali, Franklin Riet-Correa, Mizael Machado, Daniel Cook","doi":"10.1002/cbdv.71744","DOIUrl":"10.1002/cbdv.71744","url":null,"abstract":"Several species within the tribe Cestreae have been implicated in causing hepatotoxicity in livestock. Cestrum, Sessea, and Vestia are three genera that compose the tribe Cestreae within the family Solanaceae. Herein, we screen 42 Cestrum species in addition to 4 Sessea species and 1 Vestia species for the presence of carboxyparquin and parquin using herbarium specimens by high-performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS). The toxic principles, carboxyparquin and/or parquin, were detected in four Cestrum species, Sessea brasiliensis, Sessea vestioides, and Vestia foetida which are reported to be hepatotoxic to livestock. Additionally, these toxic principles were detected in an additional 18 Cestreae species that have not yet been associated with toxicity in grazing livestock. The presence of carboxyparquin and parquin was sporadic in some species ranging from 25%-100% of the specimens surveyed. No association was found between the phylogenetic relationships of the Cestrum species and the occurrence of carboxyparquin and parquin. Documenting the toxic principles of different species is a critical first step in assessing the poisoning risk of these plants to animals.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71744"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal Variation of Essential Oils Composition in a Genetically Diverse Population of Lippia alba and Its Influence on Antibacterial Activity. 遗传多样性白唇鱼种群精油成分的季节变化及其对抗菌活性的影响

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71745

Marina Erê Almeida Hummel Pimenta Santos, Taila Gomes Botelho, Camila Delarmelina, Walter José Siqueira, Marta Cristina Teixeira Duarte, Marcia Ortiz Mayo Marques, Jorge Maurício Costa Mondego

{"title":"Seasonal Variation of Essential Oils Composition in a Genetically Diverse Population of Lippia alba and Its Influence on Antibacterial Activity.","authors":"Marina Erê Almeida Hummel Pimenta Santos, Taila Gomes Botelho, Camila Delarmelina, Walter José Siqueira, Marta Cristina Teixeira Duarte, Marcia Ortiz Mayo Marques, Jorge Maurício Costa Mondego","doi":"10.1002/cbdv.71745","DOIUrl":"10.1002/cbdv.71745","url":null,"abstract":"Lippia alba is an aromatic plant whose essential oils (EOs) have been characterized as promising antimicrobial agents. It has been established that L. alba chemotypes are influenced by both genetic and environmental factors. We evaluated the EO yield, composition, and antimicrobial activity of 20 genotypes from a sympatric genetically diverse population of L. alba. These analyses were performed over two seasonal periods, during which climate data were collected and leaf nutrients assessed. EO yield was highest on average during summer, although genotype-specific patterns were observed. Gas chromatography-mass spectrometry identified 47 compounds, which 27 were observed to be shared among the 20 genotypes. A total of 10 of the 20 genotypes studied had seasonal shifts in predominant constituents. Minimum inhibitory concentration (MIC) assays showed high antimicrobial activity in summer samples, followed by spring, despite being more effective in the first seasonal data. Micronutrients data suggest that nutrient variation may be associated with changes in essential oil composition. Though exploratory, these results highlight the importance of considering both genotype and harvest season for EO standardization in antimicrobial phytotherapy and other potential applications.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71745"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Investigation of Stachys hissarica: Antioxidant Activity, Flavonoid Characterization, and In Silico Analysis. 毛豆的植物化学研究：抗氧化活性、类黄酮特性和硅分析。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71813

Elbek A Mukhammadiev, Michal Šoral, Francesco Cacciola, Katia Arena, Chao Liu, Mengqi Zhang, Ruirui Zhang, Doniyor R Siddikov, Sobirdjan A Sasmakov, Nilufar Z Mamadalieva

{"title":"Phytochemical Investigation of Stachys hissarica: Antioxidant Activity, Flavonoid Characterization, and In Silico Analysis.","authors":"Elbek A Mukhammadiev, Michal Šoral, Francesco Cacciola, Katia Arena, Chao Liu, Mengqi Zhang, Ruirui Zhang, Doniyor R Siddikov, Sobirdjan A Sasmakov, Nilufar Z Mamadalieva","doi":"10.1002/cbdv.71813","DOIUrl":"10.1002/cbdv.71813","url":null,"abstract":"Evaluating Stachys hissarica extracts via DPPH, FRAP, and ABTS assays revealed that the aqueous methanolic fraction exhibited strong, ascorbic acid-comparable antioxidant activity. This high potency confirms that hydrophilic phenolic compounds are the primary drivers of its radical-scavenging effect. HPLC-PDA/ESI-MS/MS analysis of the aqueous methanolic extract led to the tentative annotation of 35 metabolites, including hydroxycinnamic acid derivatives, flavonoid glycosides, acetylated and methoxylated flavones, consistent with the phytochemical profile of the Stachys genus. The antioxidant activities of these polyphenolic constituents likely support the strong radical-scavenging activity observed. In addition, five compounds were isolated from the polar extract of S. hissarica, and their chemical structures were elucidated using NMR and high-resolution mass spectrometry. Computer simulations showed that hydrophilic phenolics, such as naringenin and hesperidin, possess favorable oral bioavailability, low toxicity, and strong, stable binding affinities to the target protein. However, these computational predictions require experimental validation through biochemical and pharmacological assays.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71813"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Composition, Antioxidant and Antimicrobial Activities of Moroccan Equisetum ramosissimum Essential Oil and Butanolic Extract. 摩洛哥木犀草精油和丁醇提取物的化学成分、抗氧化和抗菌活性

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71853

Saida Sissi, Ilham Dilagui, Soukaina Ouhaddou, Sara Bellioua, Nabila Soraa, Khalid Bekkouche, Mustapha Larhsini, Mohamed Markouk

{"title":"Chemical Composition, Antioxidant and Antimicrobial Activities of Moroccan Equisetum ramosissimum Essential Oil and Butanolic Extract.","authors":"Saida Sissi, Ilham Dilagui, Soukaina Ouhaddou, Sara Bellioua, Nabila Soraa, Khalid Bekkouche, Mustapha Larhsini, Mohamed Markouk","doi":"10.1002/cbdv.71853","DOIUrl":"10.1002/cbdv.71853","url":null,"abstract":"For the first time, the chemical profile and biological activities of Moroccan Equisetum ramosissimum essential oil (EO) were investigated, alongside comparative antioxidant and antimicrobial evaluation of a previously characterized butanolic extract (BE) and molecular docking of selected constituents. Hydrodistillation yielded 0.067% (v/w, dry weight) EO, characterized by gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detection (GC-FID) and dominated by oxygenated monoterpenes and sesquiterpenes, with (+)-pulegone, γ-eudesmol, cyperotundone, viridiflorol, and carvone as major constituents. Antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power, and β-carotene bleaching assays. The EO exhibited an effective concentration producing an absorbance of 0.5 (EC50) of 50.0 µg/mL in the reducing power assay, whereas the BE showed lower IC50 (50% inhibitory concentration) values than the EO in the DPPH and β-carotene bleaching assays. Antimicrobial testing against 15 microbial strains revealed minimum inhibitory concentration (MIC) values of 0.19-12.5 mg/mL, with the lowest values against Candida albicans and Candida glabrata. Molecular docking provided complementary insights into potential interactions of selected major compounds with microbial targets. Overall, these in vitro and in silico findings support further investigation of Moroccan E. ramosissimum through toxicological and in vivo studies.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71853"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Synthesis of Novel Caudatin Derivatives Containing Arylacryloyl and Quinolyl Substituents With Anticancer Activity. 具有抗癌活性的新型芳基丙烯酰和喹啉取代尾蛋白衍生物的设计与合成。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71821

Xiao-San Li, He-Hui Zhan, Xin-Hong Wang, Tong-Xin Zheng, Bing-Bing Li, Hui-Ting Chen, An-Yu Su, Li Liu, Xue-Mei Yang, Hui Luo

{"title":"Design and Synthesis of Novel Caudatin Derivatives Containing Arylacryloyl and Quinolyl Substituents With Anticancer Activity.","authors":"Xiao-San Li, He-Hui Zhan, Xin-Hong Wang, Tong-Xin Zheng, Bing-Bing Li, Hui-Ting Chen, An-Yu Su, Li Liu, Xue-Mei Yang, Hui Luo","doi":"10.1002/cbdv.71821","DOIUrl":"10.1002/cbdv.71821","url":null,"abstract":"Caudatin (1) represents one of major C21-steroids isolated from Cynanchum otophyllum. Thirty-one novel caudatin derivatives with arylacryloyl (1a-1w) and quinolyl (2a-2h) substituents were synthesized and structurally characterized by spectroscopic analysis. Their anticancer activities were evaluated against four human cancer cell lines (MCF-7, H1299, HeLa, and HepG2). Most compounds exhibit significant antiproliferative effects, among which 1b and 2h demonstrated broad-spectrum activity with IC50 values of 8.54-12.12 and 11.43-14.25 uM, respectively. Further mechanistic studies showed that 1b induced marked apoptosis in HepG2 cells and modulated cell cycle distribution, with a higher percentage of cells accumulating in the G0/G1 phase at increased concentrations. Overall, these findings indicate that caudatin derivatives bearing arylacryloyl and quinolyl moieties constitute a preliminary chemical framework for the development of antitumor candidates for caudatin-like natural products.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71821"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, and Insecticidal Activity of Imidazo[4, 5-b]pyridine Compounds Containing Iodine. 含碘咪唑[4,5 -b]吡啶类化合物的设计、合成及其杀虫活性

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71795

Xufu Liu, Mingming Dang, Daoxin Wu, Juncheng Xiang, Liang Lv, Yunfeng Yao, Pengmian Huang, Minhua Liu

{"title":"Design, Synthesis, and Insecticidal Activity of Imidazo[4, 5-b]pyridine Compounds Containing Iodine.","authors":"Xufu Liu, Mingming Dang, Daoxin Wu, Juncheng Xiang, Liang Lv, Yunfeng Yao, Pengmian Huang, Minhua Liu","doi":"10.1002/cbdv.71795","DOIUrl":"10.1002/cbdv.71795","url":null,"abstract":"To develop new insecticides to solve the problem of pests, a series of imidazo[4,5-b]pyridine compounds containing iodine were synthesized through the active fragment splicing method. These compounds were characterized by proton nuclear magnetic resonance (1H NMR), carbon-13 nuclear magnetic resonance (13C NMR), and high-resolution mass spectrometry (HRMS). The preliminary bioassay results indicated that most of the synthesized compounds exhibited excellent insecticidal activity against Plutella xylostella (P. xylostella), Mythimna separata (M. separata), and Aphis craccivora (A. craccivora). Especially, 10a and 12a showed outstanding insecticidal activity against P. xylostella, M. separata, and A. craccivora, which was superior to oxazosulfyl. Meanwhile, the structure-activity relationship was preliminarily discussed. The work demonstrated that the prepared compounds containing imidazo[4,5-b]pyridine and iodine could provide certain hints by structural optimization for the development of new insecticides.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71795"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triterpenes with α-Glucosidase Inhibitory Activity from Euphorbia antiquorum. 大戟中具有α-葡萄糖苷酶抑制活性的三萜。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71823

Ren-Fen Ma, Chen-Yu Wang, Kai-Yue Liu, Hua Zhang

引用次数: 0

Bioengineered Iron Nanoparticles From Canavalia cathartica Seeds: A Promising Nanobiosorbent for Cr (VI) Remediation. 植物种子生物工程铁纳米颗粒：一种有前途的Cr （VI）修复纳米生物吸附剂。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71847

Neethu Cyril, James Baben George, Sylas Variyattel Paulose, Laigi Joseph

{"title":"Bioengineered Iron Nanoparticles From Canavalia cathartica Seeds: A Promising Nanobiosorbent for Cr (VI) Remediation.","authors":"Neethu Cyril, James Baben George, Sylas Variyattel Paulose, Laigi Joseph","doi":"10.1002/cbdv.71847","DOIUrl":"https://doi.org/10.1002/cbdv.71847","url":null,"abstract":"This study reports the green synthesis of iron nanoparticles (FeNP-CC) using aqueous seed extract of Canavalia cathartica, a less explored mangrove associate, and evaluates their efficacy in the remediation of hexavalent chromium (Cr(VI)) from aqueous systems. Phytochemical and spectroscopic analyses using LC-MS/MS, UV-visible spectroscopy, FTIR, HR-TEM, and XRD confirmed that bioactive constituents such as polyphenols and L-canavanine acted as both reducing and stabilizing agents during the synthesis of FeNP-CC, resulting in nanoparticles with a nanocrystalline core-shell morphology. Adsorption experiments revealed that Cr(VI) removal followed pseudo-second-order kinetics, suggesting a chemisorption-dominated mechanism. Equilibrium studies fitted best to the Freundlich isotherm model (R2 = 0.99), indicating multilayer adsorption on a heterogeneous surface. Optimal removal (100%) was achieved for 10 mg/L Cr(VI) within 50 min under acidic conditions. Furthermore, FeNP-CC successfully remediated complex, real-world laboratory wastewater containing 30 mg/L Cr(VI) despite competitive matrix interferences. Overall, this biogenic nanobiosorbent represents a highly sustainable, low-cost, and efficient candidate for practical wastewater purification.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71847"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149230927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditional Uses, Phytochemistry, and Multi-Target Pharmacological Activities of Senna alexandrina. 山番泻的传统用途、植物化学及多靶点药理活性。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71789

Diana Afrina Rella, Khai-Lin Hew, Yeun-Mun Choo

{"title":"Traditional Uses, Phytochemistry, and Multi-Target Pharmacological Activities of Senna alexandrina.","authors":"Diana Afrina Rella, Khai-Lin Hew, Yeun-Mun Choo","doi":"10.1002/cbdv.71789","DOIUrl":"https://doi.org/10.1002/cbdv.71789","url":null,"abstract":"Senna alexandrina has been widely used in traditional medicine for gastrointestinal, dermatological, metabolic, and musculoskeletal disorders. Despite extensive ethnobotanical knowledge, a comprehensive integration of its chemical constituents with pharmacological evidence remains limited. This review aimed to synthesize the traditional uses, pharmacological activities, and chemical constituents of S. alexandrina, highlighting the alignment between ethnobotanical applications and experimental evidence. Literature on ethnomedicinal usage, in vitro and in vivo pharmacological studies, and chemical characterization of S. alexandrina was systematically reviewed. A total of 219 chemical structures were compiled, along with the reported bioactivities and traditional applications. Extracts of leaves, pods, and aerial parts exhibit dose-dependent laxative, anticancer, anti-inflammatory, hepatoprotective, antioxidant, antimicrobial, antiviral, and metabolic regulatory activities. Anthraquinones, flavonoids, polysaccharides, and other secondary metabolites underpin these effects. The integration of 219 chemical structures, pharmacological data and traditional uses is rare and provides a unique resource for future mechanistic studies and drug discovery. The alignment between traditional usage and experimental pharmacology is promising, though the available evidence remains largely preclinical and extract based. Future research should isolate and characterize specific bioactive compounds to enable precise dosing, elucidate mechanisms, and advance clinical translation.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71789"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13626968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Plant Pre-Processing on the Chemical Profile of Psidium guajava L. (Myrtaceae) Essential Oil and Evaluation of Its Bioactive Potential. 植物预处理对番石榴精油化学成分的影响及其生物活性潜力评价

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71843

Tarsila da C Silva, Ari Sérgio de O Lemos, Caio Juan S Fortes, Débora N Eiriz, Elaine S Coimbra, Lucas de A Carvalho, Luciana M Chedier, Lucas M Duarte, Núbia B Andrade, Rodrigo L Fabri, Selma R de Paiva, Alessandra L Valverde

{"title":"Impact of Plant Pre-Processing on the Chemical Profile of Psidium guajava L. (Myrtaceae) Essential Oil and Evaluation of Its Bioactive Potential.","authors":"Tarsila da C Silva, Ari Sérgio de O Lemos, Caio Juan S Fortes, Débora N Eiriz, Elaine S Coimbra, Lucas de A Carvalho, Luciana M Chedier, Lucas M Duarte, Núbia B Andrade, Rodrigo L Fabri, Selma R de Paiva, Alessandra L Valverde","doi":"10.1002/cbdv.71843","DOIUrl":"10.1002/cbdv.71843","url":null,"abstract":"The chemical composition and bioactivity of essential oils depend not only on agronomic and environmental factors but also on the pre-processing of the plant material, a step that is rarely evaluated. Leaf essential oils of Psidium guajava L. were obtained by hydrodistillation from fresh or previously frozen leaves fragmented manually or mechanically, and assessed for GC-MS composition, cytotoxicity and biological activities. Fresh leaves ground in a mixer (EOFH-M) gave a sesquiterpene-rich profile dominated by β-caryophyllene and α-humulene, along with the best cell-viability profile in L929 fibroblasts and BALB/c macrophages. EOFH-M reduced nitric oxide and intracellular reactive oxygen species and showed a fungicidal effect against Candida albicans and the emerging and resistant microorganism Candida auris, whereas isolated β-caryophyllene was fungistatic. Leaf pre-processing therefore substantially influences the composition, safety and antifungal potential of P. guajava essential oil.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71843"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0