Chemistry & Biodiversity最新文献_第4页

Exploring the Anticancer and Antimicrobial Activities of Transition Metal Chelates Derived From Hydrazones: Synthesis, Spectral Investigation, Molecular Docking, and ADMET Profiling 从腙衍生的过渡金属螯合物的抗癌和抗菌活性研究：合成、光谱研究、分子对接和ADMET分析。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2026-04-08 DOI: 10.1002/cbdv.202502755

Manju Rani, Jai Devi, Binesh Kumar, Jai Kumar, Bhanu Gupta

{"title":"Exploring the Anticancer and Antimicrobial Activities of Transition Metal Chelates Derived From Hydrazones: Synthesis, Spectral Investigation, Molecular Docking, and ADMET Profiling","authors":"Manju Rani, Jai Devi, Binesh Kumar, Jai Kumar, Bhanu Gupta","doi":"10.1002/cbdv.202502755","DOIUrl":"10.1002/cbdv.202502755","url":null,"abstract":"<div>\u0000 \u0000 In this study, hydrazine ligands were synthesized from thiophene-2-carboxylic acid/benzo[b]thiophene-2-carboxylic acid hydrazides and 1,3-diphenyl-1H-pyrazole-4-carbaldehyde, along with their Co(II), Ni(II), Cu(II), and Zn(II) complexes. The synthesized compounds were thoroughly characterized and originally evaluated for their anticancer and antimicrobial potentials. Building on these findings, the compounds were evaluated against A549 and DU145 cancer cells, the IMR-90 cell line, and clinically relevant microbial strains. Among them, the Cu(II) and Zn(II) complexes (9, 10) emerged as most active, with the Cu(II) complex (9) showing pronounced anticancer efficacy against both cancer cell lines while maintaining lower sensitivity toward IMR-90 cells. Remarkably, the Cu(II) (9) and Zn(II) (6, 10) complexes exhibited outstanding antimicrobial activity, with MIC values (0.0052–0.0104 µmol/mL) comparable to those of established reference drugs, underscoring their strong therapeutic potential. Molecular docking supported the observed bioactivities, with compound (9) showing strong binding to the 4ZXT protein (−9.98 kcal/mol). Similarly, compound (10) revealed favorable binding with target protein, yielding docking scores of –9.43 kcal/mol. These interactions confirm the compounds’ strong biological affinity and therapeutic potential. ADMET results indicate favorable pharmacokinetics, supporting their drug-likeness. Their broad bioactivity provides a solid basis for future clinical studies and novel drug development.\u0000 </div>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Signaling Pathway Involved in Macrophage Activation by Fructose-Enriched Polysaccharides From Baizhu Shaoyao Powder 白术少药散富含果糖多糖活化巨噬细胞的信号通路

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2026-04-08 DOI: 10.1002/cbdv.202503456

Jiaqi Wang, Shiyue Qin, Ming Zhao, Sichun Zheng, Xiaodan Ma, Ran Guan, Wei Xu

{"title":"Signaling Pathway Involved in Macrophage Activation by Fructose-Enriched Polysaccharides From Baizhu Shaoyao Powder","authors":"Jiaqi Wang, Shiyue Qin, Ming Zhao, Sichun Zheng, Xiaodan Ma, Ran Guan, Wei Xu","doi":"10.1002/cbdv.202503456","DOIUrl":"10.1002/cbdv.202503456","url":null,"abstract":"<div>\u0000 \u0000 This study optimized ultrasound-assisted extraction (UAE) parameters for polysaccharides from Baizhu Shaoyao powder (BSP), characterized the structure of purified BSP polysaccharides (BSPP) and investigated their immunomodulatory effects on RAW264.7 macrophages. The optimal conditions yielded BSPP at 16.695 ± 0.23%. BSPP was characterized as fructose-enriched polysaccharides with a molecular weight (Mw) of 2.786 kDa, and exhibited amorphous morphology along with characteristic polysaccharide functional groups. BSPP enhanced macrophage pinocytosis and phagocytosis, upregulated antigen-presenting molecules/costimulatory markers, and stimulated inflammatory mediator production. RNA-seq revealed 1,832 DEGs, 66 GO terms, and 97 KEGG pathways with integrated network analysis identifying TNF and IL-1β as hub genes. Western blot analysis confirmed p38 MAPK/NF-κB pathway activation, and inhibitor experiments established TLR2/TLR4-mediated recognition and MyD88-dependent p38 MAPK/NF-κB signaling as essential for BSPP-induced macrophage activation. These findings provide a theoretical basis for enriching the pharmacodynamic material basis of BSP and expanding its clinical applications.\u0000 </div>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marine Chemical Diversity in Soft Corals of the Genus Heteroxenia: Ecological Significance, Metabolite Architecture, 13C-NMR Characteristics, and Biomedical Prospects 异质性软珊瑚的海洋化学多样性：生态学意义、代谢物结构、13c - nmr特征和生物医学前景

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2026-04-04 DOI: 10.1002/cbdv.202503725

Ahmed K. B. Johani, Fahd M. Abdelkarem

{"title":"Marine Chemical Diversity in Soft Corals of the Genus Heteroxenia: Ecological Significance, Metabolite Architecture, 13C-NMR Characteristics, and Biomedical Prospects","authors":"Ahmed K. B. Johani, Fahd M. Abdelkarem","doi":"10.1002/cbdv.202503725","DOIUrl":"10.1002/cbdv.202503725","url":null,"abstract":"<div>\u0000 \u0000 Marine organisms are considered as a reservoir of diverse metabolites with unique skeletons and multifaceted biological activities. Marine organisms, including Xenia, Cespitularia, and Heteroxenia, have been extensively studied in recent decades to explore their activities. Species of the genus Heteroxenia play a robust ecological role and afford a wide array of metabolites, including steroids, sesquiterpenoids, diterpenoids, and lipid derivatives with notable bioactivities as cytotoxic, antiviral, antimicrobial, and anti-inflammatory properties primarily based on in vitro studies. Fourteen compounds were isolated and their structures were elucidated based on NMR data and mass spectrometry. Most of these metabolites possess rare or uncommon structural frameworks such as gorgostane- and androstane-type steroids, and verticillane diterpenoids with an unusual C-6/C-12 skeleton, which are infrequently reported from marine sources. This review provides a comprehensive overview of Heteroxenia corals, highlighting their ecological role, metabolites isolated from Heteroxenia species, with emphasis on their 13C NMR spectroscopic features and reported bioactivities. This integrative approach provides a chemotaxonomic spectroscopic framework and identifies research gaps, that support future natural product discovery and pharmacological investigations of Heteroxenia species, while acknowledging that ecological function and general bioactivity do not necessarily predict direct therapeutic applicability and require further validation of selectivity and safety.\u0000 </div>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colorimetric Determination of Hydrogen Peroxide Based on the Enzymatic Properties of Garlic and Cuscuta campestris Extract Plants 用比色法测定大蒜和菟丝子提取物中过氧化氢的酶学性质。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2026-04-04 DOI: 10.1002/cbdv.202503419

Maryam Saadat, Gity Mirzaei, Mahsa Morvaridi, Jamal Hallajzadeh

{"title":"Colorimetric Determination of Hydrogen Peroxide Based on the Enzymatic Properties of Garlic and Cuscuta campestris Extract Plants","authors":"Maryam Saadat, Gity Mirzaei, Mahsa Morvaridi, Jamal Hallajzadeh","doi":"10.1002/cbdv.202503419","DOIUrl":"10.1002/cbdv.202503419","url":null,"abstract":"<div>\u0000 \u0000 Addressing the increasing demand for efficient enzyme-based catalysis and biomarkers, this study investigates garlic (Allium sativum, AS) and Cuscuta campestris (CC) extracts as potent biocatalysts. For the first time, their potential in hydrogen peroxide (H2O2) detection and quantification is explored through catalytic activity, substrate affinity, and sensor development. AS and CC extracts were prepared via stirring and sonication, then employed as peroxidase-mimicking enzymes. Their catalytic ability was assessed by oxidizing 3,3,5,5-tetramethylbenzidine (TMB) in the presence of H2O2. Kinetic analysis revealed that both extracts followed Michaelis-Menten behavior, exhibiting high affinity for TMB and H2O2. A novel colorimetric H2O2 sensor was developed using these plant extracts. The AS-based sensor showed a linear detection range of 11.29–148 µM with a detection limit of 39 nM, while the CC-based sensor achieved a 0.6–168 µM range with a 4.5 nM detection limit. Practical applicability was demonstrated through successful H2O2 detection in human serum and disinfectant samples, yielding accurate and reliable results. This simple, sensitive extract/TMB/H2O2 colorimetric system offers significant promise for applications in clinical diagnostics and food environment monitoring.\u0000 </div>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosorption of Pb²⁺ From Wastewater Solution Using Material Derived From Cleistocalyx operculatus Leaves: Kinetics, Isotherms, and Thermodynamic Studies. 闭锁叶源材料对废水中Pb2+的生物吸附：动力学、等温线和热力学研究。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2026-04-01 DOI: 10.1002/cbdv.202503049

Anh-Tuan Vu, Van Doan Nguyen

{"title":"Biosorption of Pb2+ From Wastewater Solution Using Material Derived From Cleistocalyx operculatus Leaves: Kinetics, Isotherms, and Thermodynamic Studies.","authors":"Anh-Tuan Vu, Van Doan Nguyen","doi":"10.1002/cbdv.202503049","DOIUrl":"https://doi.org/10.1002/cbdv.202503049","url":null,"abstract":"Despite the extensive use of bio-based materials for heavy metal removal, the adsorption potential of Cleistocalyx operculatus leaves (CO) remains unexplored. In this study, CO leaves were converted for the first time into a low-cost, efficient biosorbent for Pb2+ removal from aqueous solutions, addressing both performance and sustainability requirements in wastewater treatment. Characterization by FT-IR, EDX, and SEM revealed that CO has a porous structure with nitrogen- and oxygen-containing functional groups, which facilitate metal ion binding. Batch adsorption experiments evaluated the effects of pH, contact time, initial Pb2 + concentration, and temperature. The results showed that Pb2 + removal efficiency reached 86.82% after 60 min at pH of 6 and 303 K. Adsorption kinetics followed the pseudo-second-order model, while the isotherm data fit the Langmuir model, with a maximum uptake capacity of 64.59 mg/g, indicating monolayer biosorption on a homogeneous surface. Thermodynamic analysis confirmed that the Pb2 + adsorption process is spontaneous and exothermic. The CO material maintained nearly 70% efficiency after three adsorption-desorption cycles under acidic conditions. When applied to real wastewater from battery recycling and electroplating processes, removal efficiencies of 63.50% and 71.41% were achieved, demonstrating promising applicability in complex environments.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 4","pages":"e03049"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Targeted Hepatoprotection: A Combined Extract of Moringa oleifera and Urtica dioica (MU) Combats Drug-Induced Oxidative Stress and Inflammation via Antioxidant and Molecular Modulatory Effects. 多靶点肝脏保护：辣木和荨麻（MU）联合提取物通过抗氧化和分子调节作用对抗药物诱导的氧化应激和炎症。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2026-04-01 DOI: 10.1002/cbdv.202502542

Nassima Boutaoui, Nesrine Lariche, Mohamed Zakaria Stiti, Katia Mohand Saidi, Walid Bousbaa, Khellaf Rebbas, Kamel Harrouche, Smail Khelili

{"title":"Multi-Targeted Hepatoprotection: A Combined Extract of Moringa oleifera and Urtica dioica (MU) Combats Drug-Induced Oxidative Stress and Inflammation via Antioxidant and Molecular Modulatory Effects.","authors":"Nassima Boutaoui, Nesrine Lariche, Mohamed Zakaria Stiti, Katia Mohand Saidi, Walid Bousbaa, Khellaf Rebbas, Kamel Harrouche, Smail Khelili","doi":"10.1002/cbdv.202502542","DOIUrl":"https://doi.org/10.1002/cbdv.202502542","url":null,"abstract":"This study investigated the hepatoprotective effects of a combined ethanolic extract of Moringa oleifera and methanolic extract of Urtica dioica (MU), F3 (2:1 w/w), against isoniazid (INH) and rifampicin (RIF)-induced liver toxicity in rats. Formulation F3, characterized by high total phenolic (246.45 ± 1.80 µg GAE/mg) and flavonoid (67.07 ± 0.21 µg QE/mg) contents, exhibited potent in vitro antioxidant activity (e.g., DPPH IC50 of 42.66 ± 0.59 µg/mL for F3). Significantly, oral administration of F3 alone (200, 400 mg/kg) did not induce liver toxicity, maintaining normal histopathology similar to controls. Conversely, INH-RIF treatment significantly increased serum liver markers (AST, ALT, ALP, bilirubin, and triglycerides), elevated MDA levels, reduced CAT and GSH activities, and caused severe histopathological damage. The combined extract F3, particularly at 400 mg/kg, significantly reversed these biochemical and histopathological alterations. In silico ADMET, DFT, and docking analyses elucidated multi-targeted mechanisms: DFT predicted high reactivity for compounds such as riboflavin (5a), correlating with antioxidant effects. Docking showed strong binding of oleuropein (3a) and riboflavin (5a) to CYP2E1 and TNF-α, suggesting inhibition of toxic metabolite formation and inflammation. These findings highlight this natural combination's potential as an adjunctive therapy for anti-tuberculosis drug-induced liver injury.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 4","pages":"e02542"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Diversity and Distribution of Specialized Metabolites Across Different Organs of Gentiana rigescens Franch. 龙胆不同器官代谢物的化学多样性及分布。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2026-04-01 DOI: 10.1002/cbdv.202503731

Liping Ruan, Siman Gu, Juan Yao, Jiao Yin, Fusheng Wang, Anzhong Peng, Haifeng Li, Shizhi Jiang

{"title":"Chemical Diversity and Distribution of Specialized Metabolites Across Different Organs of Gentiana rigescens Franch.","authors":"Liping Ruan, Siman Gu, Juan Yao, Jiao Yin, Fusheng Wang, Anzhong Peng, Haifeng Li, Shizhi Jiang","doi":"10.1002/cbdv.202503731","DOIUrl":"10.1002/cbdv.202503731","url":null,"abstract":"<div>\u0000 \u0000 This study comprehensively investigated the distribution and diversity of specialized metabolites in different parts of Gentiana rigescens Franch. (G. rigescens). Ultra-performance liquid chromatography (UPLC) was utilized to quantify the major active constituents, while UPLC–electrospray ionization–quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q-TOF-MS/MS) enabled rapid putative identification and structural characterization of specialized metabolites. The results revealed that the gentiopicroside content in all plant parts met the minimum requirement of 1.5% stipulated in the Pharmacopoeia of the People's Republic of China (2020 edition). Notably, the concentrations of loganic acid, sweroside, mangiferin, and amarogentin were significantly higher (p < 0.01) in the flowers, whereas swertiamarin and gentiopicroside were more abundant in the roots and rhizomes. The UPLC chromatographic profiles of the different parts exhibited high similarity, sharing 29 characteristic peaks. In total, 26 compounds were putatively identified across the plant, comprising 13 iridoids, 7 flavonoids, 3 triterpenoids, and 3 xanthones, including four compounds reported for the first time within the G. rigescens. Principal component analysis (PCA) further indicated that the chemical profiles of the leaves and flowers were closely related, yet distinct from those of the roots, rhizomes, and stems. Collectively, these findings elucidate the compositional variation and distribution patterns of specialized metabolites among different plant parts, providing a scientific foundation for the comprehensive utilization of G. rigescens in ethnic and traditional medicinal practices in Yunnan, China.\u0000 </div>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Activity of Carbazole Derivatives: An In Vitro and In Vivo Study. 咔唑衍生物的抗炎活性：体外和体内研究。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2026-04-01 DOI: 10.1002/cbdv.202503786

Chao Ye, Xueqian Bai, Yijie Xue, Jianuo Song, Chuntian Cai, Xianmin Feng, Tianyi Zhang

{"title":"Anti-Inflammatory Activity of Carbazole Derivatives: An In Vitro and In Vivo Study.","authors":"Chao Ye, Xueqian Bai, Yijie Xue, Jianuo Song, Chuntian Cai, Xianmin Feng, Tianyi Zhang","doi":"10.1002/cbdv.202503786","DOIUrl":"https://doi.org/10.1002/cbdv.202503786","url":null,"abstract":"In this study, we present the anti-inflammatory effects of three sets of compounds synthesized by attaching an aminoguanidine, dihydrotriazine, or isonicotinic group to carbazole, evaluated through an ear edema model. Most of the synthesized compounds showed pronounced anti-inflammatory activity. Notably, compound 3a exhibited the most potent anti-inflammatory activity among all synthesized compounds, with 95.52% inhibition following intraperitoneal administration, and was more active than the reference drug celecoxib. Furthermore, compound 3a effectively suppressed LPS-induced NO production in RAW264.7 cells in a concentration-dependent manner, while significantly decreasing NO levels in xylene-induced mouse ear edema, demonstrating consistent NO inhibitory effects across both in vitro and in vivo inflammatory models. Molecular docking was employed to explore the binding mode of representative compound 3a with COX-1 and COX-2 enzymes. Additionally, ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) predictive assays were employed to conduct a preliminary assessment of the in vivo pharmacokinetic characteristics of the optimized derivatives. This work thereby lays a crucial theoretical groundwork for subsequent in-depth preclinical studies.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 4","pages":"e03786"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four New Naphthalene Glycosides From the Green Walnut Husks of Juglans mandshurica Maxim. 从山核桃青核桃壳中提取四种新萘苷。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2026-04-01 DOI: 10.1002/cbdv.202503601

Jie Sun, Mei Yi, Yue Yao, Dao-Shen Wang, Mei-Qi Cao, Hao-Hua Bai, Yan Liu, Xiao-Juan Zhang, Zhen-Xing Fang, Yuan-Yuan Zhou

引用次数: 0

HPLC-MS/MS Profiling and Evaluation of Antioxidant and Enzyme Inhibitory Activities of Glycyrrhiza glabra L. Crude Extracts. 甘草粗提物抗氧化和酶抑制活性的HPLC-MS/MS分析及评价

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2026-04-01 DOI: 10.1002/cbdv.71208

Hekmat B Al-Hmadi, Haïfa Debbabi, Siwar Majdoub, Simone Angeloni, Ahmed M Mustafa, Giovanni Caprioli, Gokhan Zengin, Filippo Maggi, Saoussen Hammami

{"title":"HPLC-MS/MS Profiling and Evaluation of Antioxidant and Enzyme Inhibitory Activities of Glycyrrhiza glabra L. Crude Extracts.","authors":"Hekmat B Al-Hmadi, Haïfa Debbabi, Siwar Majdoub, Simone Angeloni, Ahmed M Mustafa, Giovanni Caprioli, Gokhan Zengin, Filippo Maggi, Saoussen Hammami","doi":"10.1002/cbdv.71208","DOIUrl":"https://doi.org/10.1002/cbdv.71208","url":null,"abstract":"The present study aimed to investigate the phytochemical and biological screening of Glycyrrhiza glabra L. aerial parts and roots. Extracts were obtained by maceration using solvents of increasing polarity (chloroform, ethyl acetate, and methanol). HPLC-MS/MS analysis led to the identification of 26 phenolic compounds, with hyperoside followed by delphinidin-3,5-diglucoside and isoquercitrin identified as the main constituents of the aerial parts methanolic extract. The total phenolic and flavonoid contents varied in the range of 54.39-144.09 mg GAE/g and 16.47-65.19 mg RE/g, respectively. The phosphomolybdenum assay yielded a total antioxidant capacity of 1.64-3.40 mmol TE/g. The ability of the extracts to neutralize free radicals ranged between 45.27 and 171.00 mg TE/g for DPPH and 94.51 to 454.14 mg TE/g for ABTS assays. Furthermore, the reducing power assays, evinced that the extracts display significant activity with values ranging from 58.48 to 291.61 mg TE/g (FRAP) and 110.12 to 472.24 mg TE/g (CUPRAC). Moreover, G. glabra L. exhibited notable inhibitory effects against several enzymes (acetylcholinesterase, butyrylcholinesterase, α-tyrosinase, α-glucosidase, and α-amylase). Overall, the obtained results provide scientific evidence supporting the traditional use of the plant and suggest its potential as a promising source of bioactive compounds for further pharmacological investigation.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 4","pages":"e71208"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0