Chemistry & Biodiversity最新文献_第4页

Syringa pinnatifolia Lignans Contribute to the Cardioprotective Effect Against Ischemic Injury through the Nrf2/HO-1 Signaling Pathway in Vitro and in Vivo. 在体内和体外通过Nrf2/HO-1信号通路参与对缺血性损伤的心脏保护作用

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-13 DOI: 10.1002/cbdv.202502483

Xiaojing Ma, Guodong Yang, Changxin Liu, Wenfu Ma, Qiuyuan Ding, Xiaojuan Li, Feng Zhou, Jessore Jurat, Xiaoli Gao, Kelsang Norbu, Xingyun Chai

引用次数: 0

C11orf53 Promotes the Progression of Small Cell Lung Cancer by Regulating Glucose Metabolism. C11orf53通过调节葡萄糖代谢促进小细胞肺癌的进展。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-10 DOI: 10.1002/cbdv.202501157

Shuxian Liao, Mengxia Zhang, Shengfen Li, Yuan Gao, Ruilei Huang, Xuhong Zhao, Qian Ning, Shengsong Tang

{"title":"C11orf53 Promotes the Progression of Small Cell Lung Cancer by Regulating Glucose Metabolism.","authors":"Shuxian Liao, Mengxia Zhang, Shengfen Li, Yuan Gao, Ruilei Huang, Xuhong Zhao, Qian Ning, Shengsong Tang","doi":"10.1002/cbdv.202501157","DOIUrl":"https://doi.org/10.1002/cbdv.202501157","url":null,"abstract":"Small cell lung cancer (SCLC), the most malignant subtype of lung cancer, is a major cause of death among lung cancer patients. Drug resistance, high recurrence, and limitations of surgery are all obstacles to SCLC treatment. Consequently, clarifying the underlying mechanism of SCLC progression and identifying potential targets for therapeutic intervention are of paramount significance for improving the clinical outcomes of SCLC patients. C11orf53 has been demonstrated to play a crucial role in the NCI-H526 cell activity. However, few studies have focused on how C11orf53 affects the activity of NCI-H526 cells and the corresponding regulatory pathways. Herein, our study shows that C11orf53 affects the viability and proliferation of SCLC NCI-H526 cells by influencing the glycolytic pathway. We established the C11orf53 overexpression and knockdown systems in the NCI-H526 cell line with C11orf53-specific small-interfering RNA and lentivirus to assess the effects of C11orf53 on the activity and proliferation of NCI-H526 cells. Furthermore, the NCI-H526 cells with C11orf53 knockdown and overexpression were utilized to elucidate the molecular mechanism of C11orf53. Our study shows that C11orf53 knockdown significantly reduced the viability and proliferation of NCI-H526 cells. Additionally, adenosine triphosphate levels, glucose consumption, lactate secretion, and the expression of key enzymes involved in the glycolytic pathway were markedly decreased in NCI-H526 cells. These findings confirmed that the effect of C11orf53 on the activity and proliferation of NCI-H526 cells is mediated by its role in regulating cellular glycolysis.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01157"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioprospecting of Labdane-Type Diterpenes From Austroeupatorium laetevirens: Molecular Networking, Structural Elucidation, and Biological Activity Evaluation. laetevirens中labdane型二萜的生物勘探：分子网络、结构解析和生物活性评价。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-10 DOI: 10.1002/cbdv.202502381

Francielli A P Valeze, Maria Eduarda V de Souza, Beatriz P Moreno, Bianca D B Sahm, Andressa L Ieque, Cleverton S Fernandes, Regiane B L Scodro, Leticia V Costa-Lotufo, Marta R B do Carmo, Andrea N L Batista, João M Batista Junior, Ernani A Basso, Maria H Sarragiotto, Debora C Baldoqui

{"title":"Bioprospecting of Labdane-Type Diterpenes From Austroeupatorium laetevirens: Molecular Networking, Structural Elucidation, and Biological Activity Evaluation.","authors":"Francielli A P Valeze, Maria Eduarda V de Souza, Beatriz P Moreno, Bianca D B Sahm, Andressa L Ieque, Cleverton S Fernandes, Regiane B L Scodro, Leticia V Costa-Lotufo, Marta R B do Carmo, Andrea N L Batista, João M Batista Junior, Ernani A Basso, Maria H Sarragiotto, Debora C Baldoqui","doi":"10.1002/cbdv.202502381","DOIUrl":"https://doi.org/10.1002/cbdv.202502381","url":null,"abstract":"Labdane-type diterpenes are the main specialized metabolites in the Austroeupatorium genus, known for diverse biological activities. This study employed molecular networking to facilitate the identification of labdanes in Austroeupatorium laetevirens, alongside isolation, structural elucidation, and evaluation of anti-Mycobacterium tuberculosis and antiproliferative activities. Ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry was used for dereplication, with data processed through the Global Natural Products Social Molecular Networking platform and visualized in Cytoscape. Structural elucidation was based on nuclear magnetic resonance spectroscopy, vibrational circular dichroism spectroscopy, and density functional theory calculations. Dereplication analysis led to the putative annotation of nine labdanes, two of which were isolated, including one new compound. Seven known compounds were also isolated, with eupatorin and eupafolin showing moderate antimycobacterial activity. Additionally, 25 compounds were putatively identified through dereplication. These findings reinforce the relevance of labdane-type diterpenes within the Austroeupatorium genus.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02381"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocatalysis and Biomedical Applications of Phytofabricated Nickel Oxide Nanoparticles via Olive Leaf Extract. 橄榄叶提取物制备氧化镍纳米颗粒的光催化及生物医学应用。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-10 DOI: 10.1002/cbdv.202501963

Nasser F Alotaibi, Ahmed Hamad Alanazi, Shaima M N Moustafa, Mohamed F Hasaneen, Hallouma Bilel, Reda Abdel-Hameed, Mohsen A M Alhamami, Jari S Algethami, Amr M Nassar

{"title":"Photocatalysis and Biomedical Applications of Phytofabricated Nickel Oxide Nanoparticles via Olive Leaf Extract.","authors":"Nasser F Alotaibi, Ahmed Hamad Alanazi, Shaima M N Moustafa, Mohamed F Hasaneen, Hallouma Bilel, Reda Abdel-Hameed, Mohsen A M Alhamami, Jari S Algethami, Amr M Nassar","doi":"10.1002/cbdv.202501963","DOIUrl":"https://doi.org/10.1002/cbdv.202501963","url":null,"abstract":"Phytosynthesis of nanoparticles (NPs) is a green, effective, and sustainable method that uses the phytochemicals in the biosynthesis of NPs as reducing and stabilizing agents. In this work, two forms of nickel oxide (NiO) have been synthesized and characterized using different physicochemical tools. The first NiO is NiO-1, which is photosynthesized using olive (Olea europaea L) leaf extract and nickel nitrate as a precursor of nickel ions. The second NiO is NiO-2, which is synthesized via the thermal treatment of NiO-1 at 550°C. The photocatalytic, antioxidant, and antimicrobial activities have been studied. The semiconducting properties of NiO-2 were higher than NiO-1, with energy band gap values of 3.4 eV and 5.2 eV, respectively. When exposed to natural sunlight, NiO-2 broke down 95% of 5 ppm crystal violet dye in 40 min, making it an effective and sustainable photocatalyst. The antioxidant activity has been studied using the 2,2-diphenyl-1-picrylhydrazyl assay and followed the order olive leaf extract > NiO-2 > NiO-1 with IC50 values of 2.3, 7.66, and 14.49, respectively. The antimicrobial activity has been evaluated against pathogenic microbes, Escherichia coli, Staphylococcus aureus, and Candida albicans. The best antimicrobial resulted from NiO-1, which showed more inhibition zones than the extract and NiO-2 against the tested microbes.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01963"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of Taxifolin Against Monochloroacetic Acid-Induced Skin Damage via Inhibition of the cGAS/STING/NF-κB Pathway. 紫杉醇通过抑制cGAS/STING/NF-κB通路对一氯乙酸诱导的皮肤损伤的保护作用

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-10 DOI: 10.1002/cbdv.202502583

Hui Yu, Le Wang, Shuhan Yang, Dan Liu, Xiangyu Cao

{"title":"Protective Effect of Taxifolin Against Monochloroacetic Acid-Induced Skin Damage via Inhibition of the cGAS/STING/NF-κB Pathway.","authors":"Hui Yu, Le Wang, Shuhan Yang, Dan Liu, Xiangyu Cao","doi":"10.1002/cbdv.202502583","DOIUrl":"https://doi.org/10.1002/cbdv.202502583","url":null,"abstract":"Monochloroacetic acid (MCA), a prevalent byproduct of water disinfection, is increasingly detected in aquatic environments, raising concerns about its detrimental effects on skin health. Taxifolin (TAX), a flavonoid with diverse pharmacological properties, has received limited attention in dermatological applications. In this study, TAX significantly alleviated MCA-induced damage in human epidermal keratinocytes (HaCaT cells) was demonstrated. MTT assays revealed that 12.5, 25, and 50 µM concentrations of TAX effectively reversed the MCA-induced decrease in HaCaT cells. Furthermore, immunofluorescence and flow cytometry analyses showed that TAX markedly reduced reactive oxygen species (ROS) levels and apoptosis induced by MCA. In addition, TAX attenuated ROS-mediated DNA damage caused by MCA. Given that DNA damage can activate the cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS), the involvement of the cGAS-stimulator of interferon genes (STING) pathway was further examined. The results showed that TAX inhibited the activation of cGAS-STING pathway, thereby preventing downstream NF-κB activation and the release of proinflammatory cytokines. These findings demonstrate the protective effect of TAX against MCA-induced skin damage and highlight its potential as a candidate for future dermatological applications.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02583"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of Biofilm Formation and Cell Wall Targeting Activity of Endophytic Nocardiopsis Strain KDCGRAW Isolated From the Indian Sundarbans. 印度孙德尔本斯Nocardiopsis内生菌株KDCGRAW生物膜形成和细胞壁靶向活性的抑制

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-10 DOI: 10.1002/cbdv.202501947

Pankaj Paul, Sandip Dolui, Sumee Ireen, Subhadip Bisoi, Sangita Palai, Poulomi Biswas, Kamalika Mazumder, Kaushik Biswas

{"title":"Inhibition of Biofilm Formation and Cell Wall Targeting Activity of Endophytic Nocardiopsis Strain KDCGRAW Isolated From the Indian Sundarbans.","authors":"Pankaj Paul, Sandip Dolui, Sumee Ireen, Subhadip Bisoi, Sangita Palai, Poulomi Biswas, Kamalika Mazumder, Kaushik Biswas","doi":"10.1002/cbdv.202501947","DOIUrl":"https://doi.org/10.1002/cbdv.202501947","url":null,"abstract":"The discovery of new antimicrobials is one of the most crucial approaches to tackling the antimicrobial resistance crisis. Strain KDCGRAW was isolated from the root of Rhizophora apiculata (Garjan tree) from the Bonnie camp subdivision of Sundarbans, West Bengal, India. 16S rRNA gene sequencing analysis revealed that the strain belongs to the genus Nocardiopsis. The strain was subjected to fermentation, and the crude extract was analyzed using GC-MS. The extract inhibited Escherichia coli MTCC 1195 biofilm formation and showed a percentage biofilm remaining of 77.69% for 1/2 MIC, 69.18% for MIC, and 51.56% for 2 MIC, respectively. However, MIC and 2 MIC doses of the extract showed a significant biofilm formation inhibition and the percentage biofilm remaining determined was 51.89% and 43.97%, respectively, as compared to the 1/2 MIC 74.93% against Staphylococcus aureus MTCC 2940. The in silico docking and molecular dynamics study revealed that compound 1 and compound 9 exhibited the best docking energies with the two selected biofilm-associated proteins, achieving binding energies of -6.84 and -7.7 kcal/mol on 5XP0 and 7C7R, respectively. In vivo toxicity analysis using brine shrimp revealed that the extract was nontoxic at all the concentration ranges, namely, 1/2 MIC, MIC, and 2 MIC.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01947"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four New Compounds From Lactuca indica That Inhibit Nitric Oxide Production. 四种抑制一氧化氮生成的新化合物。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-10 DOI: 10.1002/cbdv.202502438

Do Thi Trang, Nguyen Thi Ha, Ngo Anh Bang, Phan Thi T Huong, Nguyen Huy Hoang, Nguyen Viet Dung, Duong Thi Dung, Nguyen Thi Cuc, Pham Hai Yen, Bui Huu Tai, Phan Van Kiem

{"title":"Four New Compounds From Lactuca indica That Inhibit Nitric Oxide Production.","authors":"Do Thi Trang, Nguyen Thi Ha, Ngo Anh Bang, Phan Thi T Huong, Nguyen Huy Hoang, Nguyen Viet Dung, Duong Thi Dung, Nguyen Thi Cuc, Pham Hai Yen, Bui Huu Tai, Phan Van Kiem","doi":"10.1002/cbdv.202502438","DOIUrl":"https://doi.org/10.1002/cbdv.202502438","url":null,"abstract":"Nitric oxide (NO) is produced by both endothelial and neuronal cells and is involved in various biological processes, including vasodilation, neuromodulation, the immune response, and platelet aggregation. Excessive NO production can trigger the progression of pathological conditions, including inflammation and oxidative stress. Lactuca indica L. is a well-known oriental medicinal plant used to treat several inflammatory diseases. To clarify the active ingredients thereof, four new compounds, (7R,8S,11S)-ferulin 15-O-β-D-glucopyranoside (1), (2R,3R)-2,3-dihydro-2-ethyl-3-methylmaleimide N-β-D-glucopyranoside (2), 7S,7S,8R,8R-(-)-neo-olivil-4-O-β-D-glucopyranoside (3), and (1R,4S,7R,5E)-1,4-dihydroxy-germacra-5,10(14)-diene (4), and six known compounds (5-10) were isolated from the plant and their NO inhibitory activities evaluated. The chemical structures of the new compounds, including the absolute configurations, were fully determined via high-resolution electrospray ionization mass spectrometry, nuclear magnetic resonance, and both experimental and time-dependent density functional theory-calculated electronic circular dichroism spectra. The new compounds and the known sesquiterpenoids were chemically diverse, major components of L. indica extracts. Compounds 2 and 10 potentially inhibit NO production (half-maximal inhibitory concentration of 25.3 and 21.4 µM), suggesting that maleimide derivatives could serve as both therapeutic inhibitors and lead compounds for the discovery of anti-inflammatory agents.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02438"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epifriedelinol From Aster tataricus Suppresses Osteoclast Differentiation and Bone Resorption via MAPK-Mediated Inhibition of NFATc1/c-Fos in RAW264.7 and BMM Cells: An In Vitro Study. 紫菀Epifriedelinol通过mapk介导的抑制RAW264.7和BMM细胞中NFATc1/c-Fos抑制破骨细胞分化和骨吸收：一项体外研究

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-10 DOI: 10.1002/cbdv.202501044

Xiangdong Su, Nguyen Viet Phong, Badmaarag-Altai Chuluunbaatar, Yunjo Soh, Seo Young Yang

{"title":"Epifriedelinol From Aster tataricus Suppresses Osteoclast Differentiation and Bone Resorption via MAPK-Mediated Inhibition of NFATc1/c-Fos in RAW264.7 and BMM Cells: An In Vitro Study.","authors":"Xiangdong Su, Nguyen Viet Phong, Badmaarag-Altai Chuluunbaatar, Yunjo Soh, Seo Young Yang","doi":"10.1002/cbdv.202501044","DOIUrl":"https://doi.org/10.1002/cbdv.202501044","url":null,"abstract":"Osteoporosis, characterized by excessive osteoclast-mediated bone resorption, necessitates innovative therapies to overcome the limitations of current treatments. This study explores the effects of epifriedelinol (EFD), a triterpene obtained from Aster tataricus L.fil., on RANKL-induced osteoclastogenesis in RAW264.7 cells and bone marrow-derived macrophages. Concentrations up to 10 µM of EFD exhibited no cytotoxicity but strongly impeded RANKL-induced osteoclast differentiation, as indicated by a decrease in TRAP-positive multinucleated cells in both cell types. EFD at least partially inhibited the activation of the MAPK signaling pathways (ERK, JNK, p38) and suppressed key transcription factors NFATc1 and c-Fos, essential for osteoclast-specific gene expression (TRAP, RANK, MMP-9, cathepsin K). Moreover, EFD reduced RANKL-induced bone resorption in BMMs, demonstrating decreased resorption pit area in a dose-dependent manner. These findings indicate that EFD inhibits osteoclast differentiation and function by targeting the MAPK-mediated NFATc1/c-Fos pathway, highlighting its potential as a natural treatment for osteoclast-related disorders such as osteoporosis.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01044"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality Assessment of Crude and Vinegar-Processed Bupleuri Radix Using High-Performance Liquid Chromatography Fingerprint and Chemometric Analysis. 用高效液相色谱指纹图谱和化学计量分析评价粗柴胡和醋制柴胡的质量。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-10 DOI: 10.1002/cbdv.202501653

Ruimeng Zhao, Zicheng Ma, Chuang Li, Meiqi Liu, Lili Sun, Rui Huang, Meiling Chen, Yanan Liu, Xiaoliang Ren

{"title":"Quality Assessment of Crude and Vinegar-Processed Bupleuri Radix Using High-Performance Liquid Chromatography Fingerprint and Chemometric Analysis.","authors":"Ruimeng Zhao, Zicheng Ma, Chuang Li, Meiqi Liu, Lili Sun, Rui Huang, Meiling Chen, Yanan Liu, Xiaoliang Ren","doi":"10.1002/cbdv.202501653","DOIUrl":"https://doi.org/10.1002/cbdv.202501653","url":null,"abstract":"Bupleuri Radix (BR), a principal botanical drug in traditional Chinese medicine, is valued for its multifaceted pharmacological activities, including anti-inflammatory, analgesic, and hepatoprotective properties. Nevertheless, critical challenges persist concerning the ambiguous botanical authentication of crude origins and inconsistent quality control in processed BR materials. In this study, high-performance liquid chromatography fingerprints were successfully established, and the similarity was 0.814-0.923. Subsequently, through hierarchical cluster analysis and principal component analysis, the samples were initially classified into two origins: Bupleurum chinense DC. and Bupleurum scorzonerifolium Willd. Within each origin group, the specimens were further stratified into two subgroups: crude and vinegar-processed BR. Orthogonal partial least squares-discriminant analysis was applied to confirm classification results and obtain the chemical markers. The content determination results showed that Saikosaponin a (SSa) and Saikosaponin d (SSd) in both origins exhibited notable reductions following the vinegar-processing procedure, while Saikosaponin b1 (SSb1) and Saikosaponin b2 (SSb2) demonstrated marked increases. Network pharmacology and molecular docking techniques demonstrated that active molecules have a higher affinity for ALB and CASP3. The methods and results of this study provide a reliable basis for the identification and rational utilization of BR.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01653"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pesticidal Potency With Dynamic Chemical Profiles: A Comprehensive Seasonal Study of Alpinia nigra (Gaertn.) Burtt Essential Oils With Possible Mechanistic Approach. 具有动态化学特征的杀虫效力：黑高梅（Alpinia nigra）季节性综合研究伯特精油与可能的机械方法。

IF 2.5 3区化学

Chemistry & Biodiversity Pub Date : 2025-10-08 DOI: 10.1002/cbdv.202501784

Shailja Singh, Om Prakash, Stuti Arya, Tanuja Kabdal, Ravendra Kumar, Sonu Kumar Mahawer, Shiv Kumar Dubey, Dharmendra Singh Rawat, Satya Kumar

{"title":"Pesticidal Potency With Dynamic Chemical Profiles: A Comprehensive Seasonal Study of Alpinia nigra (Gaertn.) Burtt Essential Oils With Possible Mechanistic Approach.","authors":"Shailja Singh, Om Prakash, Stuti Arya, Tanuja Kabdal, Ravendra Kumar, Sonu Kumar Mahawer, Shiv Kumar Dubey, Dharmendra Singh Rawat, Satya Kumar","doi":"10.1002/cbdv.202501784","DOIUrl":"https://doi.org/10.1002/cbdv.202501784","url":null,"abstract":"This study investigates the seasonal variation in chemical composition, yield, and biological activities of Alpinia nigra essential oil (ANEO) collected monthly from October 2021 to September 2022. The highest oil yield (0.40%) was recorded in January. GC-MS analysis identified 1,8-cineole as the dominant compound, alongside seasonal fluctuations in β-pinene, α-caryophyllene, and caryophyllene oxide. The biological activities exhibited significant seasonal variation: nematicidal activity against Meloidogyne incognita peaked in September, October and February, achieving up to 100% mortality at 1.0 µL/mL within 96 h; herbicidal activity against Raphanus raphanistrum was strongest in winter, with 100% inhibition of seed germination, root, and shoot growth; while antifeedant activity against Spodoptera litura was maximum in February, March and September (up to 82% feeding inhibition). Molecular docking studies highlighted strong binding of caryophyllene oxide to target proteins-acetylcholinesterase for nematicidal activity (8.6 kcal/mol), acyl-ACP thioesterase for herbicidal activity (7.3 kcal/mol), and ACh-binding protein for antifeedant activity (7.0 kcal/mol)-underscoring its broad-spectrum bioactivity. Based on these findings, it can be inferred that linking ANEO into integrated pest management systems could revolutionize sustainable agriculture by offering a possible effective alternative to synthetic agrochemicals, which can contribute to global efforts in reducing chemical pesticide reliance and to the development of eco-friendly botanical pesticides.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e01784"},"PeriodicalIF":2.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0