Chemistry & Biodiversity最新文献_第5页

Enzymatic Synthesis of a Novel α-Linolenic Acid-Enriched Phytoceramide From Perilla Seed Oil and Its Multifunctional Bioactivity in Skin Barrier Repair and Anti-Aging. 酶法合成富含α-亚麻酸的紫苏籽油植物神经酰胺及其在皮肤屏障修复和抗衰老中的多功能生物活性

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71808

Jumao Yuan, Ning Hao, Borui Shi, Zhenzhen Wang, Jie Yu, Nuo Shi, Lin Lin

{"title":"Enzymatic Synthesis of a Novel α-Linolenic Acid-Enriched Phytoceramide From Perilla Seed Oil and Its Multifunctional Bioactivity in Skin Barrier Repair and Anti-Aging.","authors":"Jumao Yuan, Ning Hao, Borui Shi, Zhenzhen Wang, Jie Yu, Nuo Shi, Lin Lin","doi":"10.1002/cbdv.71808","DOIUrl":"10.1002/cbdv.71808","url":null,"abstract":"Ceramides are essential lipid components of the skin barrier, accounting for approximately 50% of intercellular lipids in the stratum corneum. Their deficiency is associated with various skin disorders, including atopic dermatitis and xerosis. This study aimed to enzymatically synthesize a novel phytoceramide from perilla seed oil (PSO-Cer) and evaluate its multifaceted bioactivity, including skin barrier enhancement and anti-aging effects, in comparison with oleic acid-derived Ceramide IIIB. PSO-Cer was synthesized enzymatically and characterized by HPLC-CAD and LC-QTOF. Its biological effects were assessed in human keratinocytes (HaCaT) and dermal fibroblasts-adult (HDF-a) through cytotoxicity assays, qPCR of genes related to barrier function and extracellular matrix (ECM) synthesis, western blot, and transcriptome sequencing. HPLC-CAD confirmed PSO-Cer was rich in polyunsaturated fatty acid chains, notably α-linolenic acid (34.49%). Both PSO-Cer and Ceramide IIIB were non-cytotoxic up to 25 µg/mL and significantly upregulated genes critical for epidermal barrier function (FLG, IVL, TGM1, CERS3, and ELOVL4) and ECM components (COL1A1, COL3A1, and ELN) in UVB-irradiated fibroblasts. Transcriptome analysis revealed that while both ceramides shared common mechanisms, namely activation of mTOR signaling and sphingolipid metabolism, PSO-Cer exhibited distinct properties, positioning it as a promising multifunctional active for advanced skincare formulations aimed at comprehensive skin health.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71808"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Argymekosides A-C, Three Undescribed 21α-Hydroxyoleanolic Acid Glycosides From Argyreia mekongensis and Their Cytotoxic Activity. 银杏苷A-C、三种未描述的21α-羟基齐墩果酸苷及其细胞毒活性

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71814

Tran Thi Ngoc Hanh, Nguyen Huu Toan Phan, Nguyen Thi Thu Hien, Pham Van Huyen, Nguyen Huu Huong Duyen, Nguyen Thi Dieu Thuan, Duong Thi Hai Yen, Bui Huu Tai, Phan Van Kiem

{"title":"Argymekosides A-C, Three Undescribed 21α-Hydroxyoleanolic Acid Glycosides From Argyreia mekongensis and Their Cytotoxic Activity.","authors":"Tran Thi Ngoc Hanh, Nguyen Huu Toan Phan, Nguyen Thi Thu Hien, Pham Van Huyen, Nguyen Huu Huong Duyen, Nguyen Thi Dieu Thuan, Duong Thi Hai Yen, Bui Huu Tai, Phan Van Kiem","doi":"10.1002/cbdv.71814","DOIUrl":"10.1002/cbdv.71814","url":null,"abstract":"Three previously undescribed 21α-hydroxyoleanolic acid glycosides, designated Argymekosides A-C (1-3), together with eight known compounds (4-11), were isolated from the aerial parts of Argyreia mekongensis Gagnep. & Courchet. Their structures were elucidated by comprehensive spectroscopic analyses, including HRESIMS and 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, as well as comparison with published data. The absolute configurations of three new compounds were determined by electronic circular dichroism (ECD) calculations. The isolated compounds were evaluated for their cytotoxic activities against HepG2, MCF-7, and SK-LU-1 human cancer cell lines. Compound 5 exhibited potent cytotoxicity toward all three cell lines, with IC50 values of 5.06, 5.70, and 5.79 µM, respectively. Compound 4 displayed moderate cytotoxic activity against all tested cell lines (IC50 = 26.73-35.53 µM), whereas compound 6 showed weak activity against HepG2 (IC50 = 72.03 µM) and MCF-7 cells (IC50 = 91.51 µM). The remaining compounds were inactive, with IC50 values exceeding 100 µM.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71814"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Plant Pre-Processing on the Chemical Profile of Psidium guajava L. (Myrtaceae) Essential Oil and Evaluation of Its Bioactive Potential. 植物预处理对番石榴精油化学成分的影响及其生物活性潜力评价

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71843

Tarsila da C Silva, Ari Sérgio de O Lemos, Caio Juan S Fortes, Débora N Eiriz, Elaine S Coimbra, Lucas de A Carvalho, Luciana M Chedier, Lucas M Duarte, Núbia B Andrade, Rodrigo L Fabri, Selma R de Paiva, Alessandra L Valverde

{"title":"Impact of Plant Pre-Processing on the Chemical Profile of Psidium guajava L. (Myrtaceae) Essential Oil and Evaluation of Its Bioactive Potential.","authors":"Tarsila da C Silva, Ari Sérgio de O Lemos, Caio Juan S Fortes, Débora N Eiriz, Elaine S Coimbra, Lucas de A Carvalho, Luciana M Chedier, Lucas M Duarte, Núbia B Andrade, Rodrigo L Fabri, Selma R de Paiva, Alessandra L Valverde","doi":"10.1002/cbdv.71843","DOIUrl":"10.1002/cbdv.71843","url":null,"abstract":"The chemical composition and bioactivity of essential oils depend not only on agronomic and environmental factors but also on the pre-processing of the plant material, a step that is rarely evaluated. Leaf essential oils of Psidium guajava L. were obtained by hydrodistillation from fresh or previously frozen leaves fragmented manually or mechanically, and assessed for GC-MS composition, cytotoxicity and biological activities. Fresh leaves ground in a mixer (EOFH-M) gave a sesquiterpene-rich profile dominated by β-caryophyllene and α-humulene, along with the best cell-viability profile in L929 fibroblasts and BALB/c macrophages. EOFH-M reduced nitric oxide and intracellular reactive oxygen species and showed a fungicidal effect against Candida albicans and the emerging and resistant microorganism Candida auris, whereas isolated β-caryophyllene was fungistatic. Leaf pre-processing therefore substantially influences the composition, safety and antifungal potential of P. guajava essential oil.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71843"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Fingerprinting of Sanchezia nobilis Hook. F. Leaf Extract and Evaluation of Anxiolytic, Cytotoxic, and Antioxidant Activities In Vivo, In Vitro, and In Silico. 三叶草植物化学指纹图谱研究。F.叶片提取物及其体内、体外和硅片抗焦虑、细胞毒和抗氧化活性的评价。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71776

Progga Paramita Paul, Musfiqur Rahman Sakib, Pritam Kundu, Dabashis Chakraborty, Tasnim Fatema, Shahriar Hossen, Ahsan Abid, Trina Mitra, Manik Chandra Shill, Utpal Kumar Karmakar

{"title":"Phytochemical Fingerprinting of Sanchezia nobilis Hook. F. Leaf Extract and Evaluation of Anxiolytic, Cytotoxic, and Antioxidant Activities In Vivo, In Vitro, and In Silico.","authors":"Progga Paramita Paul, Musfiqur Rahman Sakib, Pritam Kundu, Dabashis Chakraborty, Tasnim Fatema, Shahriar Hossen, Ahsan Abid, Trina Mitra, Manik Chandra Shill, Utpal Kumar Karmakar","doi":"10.1002/cbdv.71776","DOIUrl":"10.1002/cbdv.71776","url":null,"abstract":"Present studies emphasize the pharmacological, toxicological, and molecular simulation studies of the potent phytoconstituents in the Sanchezia nobilis leaf extract (SNE) and its nonpolar and polar fractions. We identified 27 phytoconstituents in SNE using Gas Chromatography Mass Spectrometry (GC-MS), where aniline, dibutyl phthalate, and isoquinoline are noteworthy. Anxiolytic assessments by hole board test (HBT) and elevated plus maze test (EPMT) demonstrated dose-dependent effects of nonpolar and polar fractions of SNE. Both fractions also exhibited minimal cytotoxicity in brine shrimp lethality test. SNE crude extract demonstrated good antioxidant properties. In silico analysis revealed promising binding affinities of aniline and isoquinoline with target protein molecules responsible for anxiolytic and antidepressive effects. Molecular dynamics (MD) modelling and quantitative chemical-based DFT approaches confirmed satisfactory pharmacokinetics (PK) and toxicity profiles for the selected medications. HOMO-LUMO analysis highlighted the remarkable features of the chosen components. MD studies also supported aniline and isoquinoline as potential candidates requiring further pharmacological validation due to their interactions with chimeric alpha1GABAA receptor proteins. Our data provided promising drug-like phytoconstituents in the S. nobilis leaf offering future drug discovery in mental health treatment.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71776"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Composition and Multi-Target Bioactivity of Salvia sclarea L. Essential Oil From the Algerian Edough Massif: Antimicrobial, Enzyme-Inhibitory, and Molecular Docking Studies. 阿尔及利亚艾多山鼠尾草挥发油的化学成分和多靶点生物活性：抗菌、酶抑制和分子对接研究

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71811

Manel Lina Djendi, Chahrazed Benzaid, Ali Dekir, Houssem Chenna, Fouzia Trea, Sarah Rahal, Lina Raghad Klaiaia, Sağlam Kübra

{"title":"Chemical Composition and Multi-Target Bioactivity of Salvia sclarea L. Essential Oil From the Algerian Edough Massif: Antimicrobial, Enzyme-Inhibitory, and Molecular Docking Studies.","authors":"Manel Lina Djendi, Chahrazed Benzaid, Ali Dekir, Houssem Chenna, Fouzia Trea, Sarah Rahal, Lina Raghad Klaiaia, Sağlam Kübra","doi":"10.1002/cbdv.71811","DOIUrl":"10.1002/cbdv.71811","url":null,"abstract":"Salvia sclarea L. (clary sage) is widely used in Algerian traditional medicine, yet its essential oil from the Edough Mountains (northeastern Algeria) remains poorly characterized. An ethnobotanical survey among 85 informants revealed high recognition (RFC = 0.918) and versatility (UV = 1.671), with predominant uses against digestive, nervous, and gynecological disorders (ICF up to 0.88). Hydrodistillation of the aerial parts yielded 1.90% (w/w) of a pale-yellow essential oil dominated by oxygenated monoterpenes (68.95%), mainly linalyl anthranilate (47.75%), and linalool (16.24%). The oil showed potent antimicrobial activity (MIC 15.32-1000 µg/mL), strong antibiofilm effects (up to 76.02% inhibition), remarkable antioxidant capacity (DPPH EC50 = 40.38 µg/mL), anti-inflammatory activity (EC50 = 291.10 µg/mL), and interesting inhibitory effects on acetylcholinesterase (EC50 = 64.40 µg/mL) and α-amylase (EC50 = 69.49 µg/mL). These findings suggest that the Algerian chemotype of S. sclarea may represent a promising source of bioactive natural compounds. Molecular docking and 100 ns molecular dynamics simulations elucidated the binding modes and stability of the major constituents in the enzyme active sites. This study validates traditional knowledge and positions the oil as a promising natural resource for managing oxidative stress-related and microbial disorders.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71811"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imidazo[1,2-b]Pyrazole-1,2,4-oxadiazole Linked 1,2,3-Triazoles: Synthesis, Antibacterial, Biofilm, and In Silico Studies. 咪唑[1,2-b]吡唑-1,2,4-恶二唑- 1,2,3-三唑的合成、抗菌、生物膜和硅研究。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71816

Suresh Kumar Murahari, Kavitha Siddoju

{"title":"Imidazo[1,2-b]Pyrazole-1,2,4-oxadiazole Linked 1,2,3-Triazoles: Synthesis, Antibacterial, Biofilm, and In Silico Studies.","authors":"Suresh Kumar Murahari, Kavitha Siddoju","doi":"10.1002/cbdv.71816","DOIUrl":"10.1002/cbdv.71816","url":null,"abstract":"The growing incidence of bacterial resistance, especially in gram-positive infections, emphasizes how urgently new antibacterial medicines must be developed. This study presents the rational design and synthesis of a series of fused imidazo[1,2-b]pyrazole-1,2,4-oxadiazole-1,2,3-triazole hybrids (8a-8n) employing a multi-step synthetic approach that includes oxidative cyclisation, amidoxime formation, Vilsmeier-mediated cyclodehydration, and Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The synthesized compounds were assessed for their in vitro antibacterial efficacy against Bacillus subtilis, Staphylococcus aureus, and Staphylococcus epidermidis. Multiple derivatives displayed notable antibacterial activity, with compounds 8j and 8l identified as the most effective (MIC = 1.56 µg/mL), exhibiting antibacterial efficacy comparable to or surpassing that of the reference medication dicloxacillin. Biofilm inhibition tests further indicated that compounds 8j and 8l exhibit substantial antibiofilm action. Molecular docking analyses targeting penicillin-binding protein (PDB ID: 1MWT) demonstrated advantageous binding affinities, with compound 8k displaying the most favorable binding score (-9.10 kcal/mol), corroborating the experimental results. Structure-activity relationship (SAR) research revealed that the inclusion of electron-withdrawing substituents, especially dihalogen groups, markedly increases antibacterial efficacy. These results underscore the therapeutic potential of fused imidazo[1,2-b]pyrazole-1,2,4-oxadiazole-1,2,3-triazole hybrids as effective antibacterial and antibiofilm agents against gram-positive bacterial infections.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71816"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Compounds and Antidiabetic Properties of Launaea mucronata Hydroethanolic Extract: Phytochemical and Pharmacological Insights. 月桂水乙醇提取物的生物活性化合物和抗糖尿病特性：植物化学和药理学见解。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71780

Amira Mohamed, Dalia El Amir, Maha M Abdel-Fattah, Mohamed A Zaki, Rabab Mohammed, Marwa H A Hassan

{"title":"Bioactive Compounds and Antidiabetic Properties of Launaea mucronata Hydroethanolic Extract: Phytochemical and Pharmacological Insights.","authors":"Amira Mohamed, Dalia El Amir, Maha M Abdel-Fattah, Mohamed A Zaki, Rabab Mohammed, Marwa H A Hassan","doi":"10.1002/cbdv.71780","DOIUrl":"10.1002/cbdv.71780","url":null,"abstract":"Launaea mucronata has been traditionally used in folk medicine worldwide for managing various diseases. This study investigated the phytochemical composition and biological activities of the hydroethanolic extract of L. mucronata aerial parts. Total phenolic and flavonoid contents were 63.77 ± 0.21 mg GAE/g and 20.91 ± 1.56 mg QE/g, respectively. Phytochemical investigation yielded lupeol (1) and β-sitosterol (2) from the n-hexane fraction; ethyl caffeate (3) and apigenin (4) from the dichloromethane fraction; apigenin (4), luteolin (5), and apigenin-7-O-glucuronide (6) from the ethyl acetate fraction. Antioxidant capacity, assessed via 2,2‑diphenyl‑1‑picrylhydrazyl (DPPH, 109.30 ± 0.75 mg AAE/g) and phosphomolybdenum (119.18 ± 0.93 mg AAE/g) assays, was notable. The extract also showed significant antidiabetic potential, inhibiting α-glucosidase (IC50 = 0.14 ± 0.005 mg/mL) and α-amylase (IC50 = 0.23 ± 0.007 mg/mL), with activity comparable to acarbose (IC50 = 0.07 ± 0.002 mg/mL and 0.09 ± 0.003 mg/mL, respectively). In vivo, alloxan-induced diabetic rats given oral doses (200 and 400 mg/kg, 21 days) exhibited significant hypoglycemic effects, moderate insulinotropic activity, antioxidant actions, and histological improvements in key metabolic organs. These findings suggest L. mucronata as a promising natural candidate for further development as an adjunct therapy for diabetes mellitus (DM).","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71780"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Untargeted Metabolomics-Based Analysis of Metabolic Differences in Different Parts of Bidens bipinnata L. 基于非靶向代谢组学的针山楂不同部位代谢差异分析

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71819

Shuya Xu, Jiaxin Dong, Fayin Tang, Lihong Li, Yunze Guo, Lijie Zuo

{"title":"Untargeted Metabolomics-Based Analysis of Metabolic Differences in Different Parts of Bidens bipinnata L.","authors":"Shuya Xu, Jiaxin Dong, Fayin Tang, Lihong Li, Yunze Guo, Lijie Zuo","doi":"10.1002/cbdv.71819","DOIUrl":"10.1002/cbdv.71819","url":null,"abstract":"Bidens bipinnata L. is a medicinal plant widely used in traditional Chinese medicine, yet the metabolic differences among its aerial parts remain largely unexplored. In this study, untargeted metabolomics based on ultra‑performance liquid chromatography‑-mass spectrometry (UPLC‑-MS) was employed to comprehensively compare the metabolite profiles of stems, leaves, and fruits, with six biological replicates per tissue. A total of 1028 metabolites were putatively annotated. Multivariate analysis, including principal component analysis (PCA) and orthogonal partial least‑squares discriminant analysis (OPLS‑DA), revealed distinct tissue-specific metabolic profiles. Flavonoids such as luteolin, kaempferol-3-O-rutinoside, and quercetin were significantly enriched in leaves. Differential metabolites were primarily enriched in flavone and flavonol biosynthesis, phenylpropanoid biosynthesis, and aromatic amino acid metabolism pathways, with distinct enrichment patterns across the three pairwise comparisons. These findings elucidate the tissue-specific accumulation patterns of secondary metabolites in B. bipinnata, providing a theoretical basis for the targeted utilization of different plant parts and supporting its potential development as a functional feed additive in animal husbandry.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71819"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemometric-Assisted Extraction Optimization and HPLC-MS Profiling of Mentha × villosa Targeting Photoprotective Activity. 以光保护活性为目标的薄荷的化学计量学辅助提取优化及HPLC-MS分析。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71764

Juliana de Medeiros Gomes, Thalisson Amorim de Souza, Márcio Vinícius Cahino Terto, Maria Beatriz Félix Mendes Nunes, Hariel Maffei Umesaki Tessaro, Joanda Paolla Raimundo E Silva, Samuel Paulo Cibulski, Luiz Alberto Lira Soares, Vera Isaac, Marcelo Sobral da Silva, Josean Fechine Tavares

{"title":"Chemometric-Assisted Extraction Optimization and HPLC-MS Profiling of Mentha × villosa Targeting Photoprotective Activity.","authors":"Juliana de Medeiros Gomes, Thalisson Amorim de Souza, Márcio Vinícius Cahino Terto, Maria Beatriz Félix Mendes Nunes, Hariel Maffei Umesaki Tessaro, Joanda Paolla Raimundo E Silva, Samuel Paulo Cibulski, Luiz Alberto Lira Soares, Vera Isaac, Marcelo Sobral da Silva, Josean Fechine Tavares","doi":"10.1002/cbdv.71764","DOIUrl":"10.1002/cbdv.71764","url":null,"abstract":"Mentha × villosa is a food and medicinal plant with long history of use. However, its use as potential ingredient for cosmetic formulations continues underexplored. Based on that, the present study sought to optimize the extraction of M. × villosa (MV-OE), characterize its composition, evaluate its antioxidant capacity and photoprotective effects alone and in combination with ethylhexyl methoxycinnamate (EHMC), a commercial sunscreen filter, in prototype formulations. Extraction was optimized through DoE, total phenolic content, and rosmarinic acid were quantified, while antioxidant activity was determined by DPPH and ABTS assays. The chemical profile of extracts was analyzed by HPLC-DAD-ESI-MSn and by HPLC-ESI-HRMS, supported by PCA. The sun protection factor (SPF) was determined using an in vitro UV-transmission method. MV-OE showed significant phenolic content and antioxidant activity, PCA proved effective for discriminating the extracts according to their phenolic composition. Besides, dereplication led to tentative assignment of 30 compounds. Formulation prototypes 5 and 6 achieved significant SPF values and enhanced EHMC performance. Altogether, these findings highlight MV-OE as a potential ingredient for future sunscreen formulations.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71764"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Freeze-Drying, Hot-Air Drying, and Thermal Treatment on Physicochemical and Bioactive Properties of Domat and Gemlik Olive Seeds. 冷冻干燥、热风干燥和热处理对Domat和Gemlik橄榄种子理化和生物活性的影响

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71797

Alev Yüksel Aydar, Tuba Aydın, Rim Hachicha Hbaieb, Mohamed Gargouri

{"title":"Effects of Freeze-Drying, Hot-Air Drying, and Thermal Treatment on Physicochemical and Bioactive Properties of Domat and Gemlik Olive Seeds.","authors":"Alev Yüksel Aydar, Tuba Aydın, Rim Hachicha Hbaieb, Mohamed Gargouri","doi":"10.1002/cbdv.71797","DOIUrl":"10.1002/cbdv.71797","url":null,"abstract":"This study investigated the impact of different processing methods (freeze-drying, thermal treatment for 25 and 35 min, and hot-air drying at 60°C and 70°C) on the proximate composition, mineral profile, phenolic compounds, antioxidant activity, and color parameters of Gemlik and Domat olive seeds. Proximate analysis revealed comparable protein (∼21%) and lipid (∼30%) contents on a dry weight basis (DWB) for both varieties. Mineral concentrations generally decreased following fermentation and subsequent thermal processing. However, this reduction was significantly less in freeze-dried samples; for instance, potassium (K) levels in fermented Gemlik seeds dropped from 429.89 to 379.76 mg/kg after lyophilization. Thermal treatment enhanced gallic acid and 3-hydroxytyrosol contents in Domat seeds, whereas all drying treatments reduced these bioactives in Gemlik seeds. The Total Phenolic Content (TPC) of Domat seeds reached its highest value following 25 min of thermal treatment (18.19 mg GAE/g DWB). DPPH radical scavenging activity decreased across all treated samples for both varieties. Color analyses ( <math><msup><mi>L</mi> <mo>∗</mo></msup> </math> , <math><msup><mi>a</mi> <mo>∗</mo></msup> </math> , <math><msup><mi>b</mi> <mo>∗</mo></msup> </math> ) indicated processing-induced changes in seed pigments, driven by pigment oxidation and Maillard reactions. These findings demonstrate that processing conditions can be tailored to preserve or modify specific bioactive and nutritional attributes of olive seeds for functional food and nutraceutical applications.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71797"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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