Chemistry & Biodiversity最新文献_第6页

UPLC-Q-TOF-MS/MS Profiling and Synergistic Anti-HCC Activity of Gallic Acid From Compound Muji Granules Combined With hUC-MSC-Exos. UPLC-Q-TOF-MS/MS分析及复合无良品颗粒未食子酸联合hUC-MSC-Exos抗hcc的协同活性

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71809

Qiang Zhang, Yige Wang, Jinnan Huo, Liying Han, Ying Meng, Yuanyuan Li, Jiaxin Shi, Xi Wu, Yongrui Bao, Shuai Wang, Tianjiao Li, Jiapeng Leng, Xiansheng Meng

{"title":"UPLC-Q-TOF-MS/MS Profiling and Synergistic Anti-HCC Activity of Gallic Acid From Compound Muji Granules Combined With hUC-MSC-Exos.","authors":"Qiang Zhang, Yige Wang, Jinnan Huo, Liying Han, Ying Meng, Yuanyuan Li, Jiaxin Shi, Xi Wu, Yongrui Bao, Shuai Wang, Tianjiao Li, Jiapeng Leng, Xiansheng Meng","doi":"10.1002/cbdv.71809","DOIUrl":"10.1002/cbdv.71809","url":null,"abstract":"Hepatocellular carcinoma (HCC) lacks effective therapies. Compound Muji Granules (MJ), a traditional Chinese medicine, shows potential anti-HCC activity, but its material basis and synergistic mechanism with exosomal delivery remain unclear. Using UPLC-Q-TOF-MS/MS, 98 compounds were identified in MJ, including 25 blood-absorbed and 23 tissue-distributed components, with gallic acid (GA) as the core active constituent. hUC-MSC-derived exosomes (hUC-MSCs-Exos) were prepared and combined with MJ or GA. In HepG2 cells and rat HCC organoids, exosome-combined treatment significantly reduced IC50, increased apoptosis and necrosis, and inhibited ATP production. Transcriptomic analysis and qPCR revealed regulation of the IL-17/MAPK/p53 axis, with downregulation of MEK1/2, CREB1, and IL17A, and activation of TP53. These findings indicate that MJ exerts anti-HCC efficacy through multi-component synergy, with GA as the main material basis, and hUC-MSCs-Exos enhance these effects by modulating IL-17/MAPK/p53 signaling, inhibiting tumor proliferation and energy metabolism, and promoting apoptosis.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71809"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Review on Ferula oopoda (Boiss. and Buhse) Boiss.: Bioactive Compounds and Pharmacological Significance. 卵阿魏综述。和Buhse) Boiss。生物活性化合物及其药理意义。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71851

Muhammad Ali, Setya Widi Ayuning Permanasari, Shah Iram Niaz, Aizhamal Baiseitova, Abdul Bari Shah, Yuan Bin Cheng

{"title":"A Comprehensive Review on Ferula oopoda (Boiss. and Buhse) Boiss.: Bioactive Compounds and Pharmacological Significance.","authors":"Muhammad Ali, Setya Widi Ayuning Permanasari, Shah Iram Niaz, Aizhamal Baiseitova, Abdul Bari Shah, Yuan Bin Cheng","doi":"10.1002/cbdv.71851","DOIUrl":"https://doi.org/10.1002/cbdv.71851","url":null,"abstract":"Ferula oopoda (Boiss. and Buhse) Boiss. is an ethnomedicinally important species widely used in Central and South Asia for the treatment of gastrointestinal, respiratory, neurological, and parasitic disorders. Despite its extensive traditional applications, comprehensive scientific evaluation of its pharmacological potential remains limited. This review systematically analyzes, for the first time, the available literature on the botany, phytochemical composition, ethnomedicinal uses, and pharmacological activities of F. oopoda, while highlighting current research gaps and future perspectives for drug discovery. To date, thirty-three secondary metabolites have been isolated from F. oopoda, including sesquiterpene lactones (STLs), sesquiterpenoids, monoterpene-phenyl esters, and phenolic acid glucosides. In addition, gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) analyses detected several low-molecular-weight constituents in essential oils and organic extracts. Both crude extracts and isolated compounds have displayed a broad spectrum of biological activities, including antibacterial, anti-plasmodial, antioxidant, anti-inflammatory, antimutagenic, and antiulcer effects. However, detailed mechanistic studies, pharmacokinetic investigations, and in vivo validations remain limited. Future research integrating structure-activity relationship studies and molecular target identification with omics-based approaches (e.g., metabolomics), in silico techniques such as molecular docking, and nano-drug delivery systems will be essential to advance its development into evidence-based therapeutic agents.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71851"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149230852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bombyx mori-Hosted Cordyceps militaris Polysaccharides: Structural Characterization and Antibacterial Activity of Native and Sulfated Derivatives. 桑家蚕寄生的蛹虫草多糖：结构表征和天然和硫酸盐衍生物的抗菌活性。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71798

Jingchun Yang, Jiani Cheng, Gaoyang Li, Wenpu Shi, Yaqi Liu, Tingyu Luo, Lixue Zheng

{"title":"Bombyx mori-Hosted Cordyceps militaris Polysaccharides: Structural Characterization and Antibacterial Activity of Native and Sulfated Derivatives.","authors":"Jingchun Yang, Jiani Cheng, Gaoyang Li, Wenpu Shi, Yaqi Liu, Tingyu Luo, Lixue Zheng","doi":"10.1002/cbdv.71798","DOIUrl":"https://doi.org/10.1002/cbdv.71798","url":null,"abstract":"Polysaccharides from Bombyx mori-hosted Cordyceps militaris are abundant but exhibit limited bioactivity, necessitating exploration of sulfated derivatives. In this study, crude polysaccharides (Bm-CMP) were extracted and further sulfated to obtain four derivatives (Bm-sCMP-1∼4). Physicochemical and structural analyses indicated that sulfation significantly modified the characteristics of Bm-CMP, notably reducing the molecular weight (Mw) and particle size while enhancing the negative surface charge and altering the monosaccharide profile. All sulfated derivatives exerted enhanced inhibitory effects against Escherichia coli and Bacillus subtilis, which were closely dependent on the degree of substitution (DS), sulfate content, and negative charge density. Notably, Bm-sCMP-2, with a moderate DS, displayed the optimal antibacterial efficacy. Collectively, this work demonstrates that sulfation is a feasible strategy to valorize polysaccharides from B. mori-hosted C. militaris, transforming them into promising candidates for novel antibacterial agents, although their in vivo efficacy and safety require further validation.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71798"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13628141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemistry, Pharmacological Potential, and Future Prospects of Abietane-Type Diterpenoids From Salvia rosmarinus. 迷迭香中abietane型二萜的植物化学、药理潜力及前景展望

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71841

Rida Siddiqui, Vipin Singh, Kapil Dev

{"title":"Phytochemistry, Pharmacological Potential, and Future Prospects of Abietane-Type Diterpenoids From Salvia rosmarinus.","authors":"Rida Siddiqui, Vipin Singh, Kapil Dev","doi":"10.1002/cbdv.71841","DOIUrl":"10.1002/cbdv.71841","url":null,"abstract":"Salvia rosmarinus, formerly known as Rosmarinus officinalis, is a medicinal plant known as one of the sources of abietane-type diterpenoids. The largest family of chemical constituents from the Salvia genus is abietanes and rearranged abietanes. Since 1976, 365 of the 545 known diterpenoids have been recognized as abietane diterpenoids. Carnosic acid, carnosol, rosmanol, epirosmanol, and their derivatives are among the bioactive abietanes that have gained much attention because of the wide spectrum of pharmacological activities. This review presents information on the distribution, isolation, biosynthesis, structural variation, degradation, semi-synthetic strategies, pharmacokinetics, and bioactivities of abietane-type diterpenoids from S. rosmarinus. Recent developments in eco-friendly extraction techniques, namely, supercritical fluid extraction, microwave-assisted extraction, ultrasound-assisted extraction, and pressurized liquid extraction, are also described in this review. The biosynthetic pathway from geranylgeranyl diphosphate to main diterpenoids, such as carnosic acid and carnosol, is also presented. Moreover, newly isolated compounds, structure-activity relationships, and antioxidant, antimicrobial, anti-inflammatory, neuroprotective, and anticancer activities are included. Moreover, the pharmacokinetics of abietane diterpenoids isolated from S. rosmarinus and their medicinal applications are also covered in this review.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71841"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valorization of Hot Trub: Extraction and Nanoparticle Encapsulation for Antitumor Applications. 热结核的增值：抗肿瘤应用的提取和纳米颗粒包封。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71827

Lilian Tatiani Dusman Tonin, Isabella Salvat Luccas, Gabriela Barbosa da Silva, Giovanna Martins Domingos, Grazielle Jesus Dos Santos, Elisângela Düsman, Ana Beatriz Sousa Santana, Patricia Aline Bressiani, Ágatha Giovanna Fragoso, Angélica Priscila Parussolo Tonin, Eduardo César Meurer

{"title":"Valorization of Hot Trub: Extraction and Nanoparticle Encapsulation for Antitumor Applications.","authors":"Lilian Tatiani Dusman Tonin, Isabella Salvat Luccas, Gabriela Barbosa da Silva, Giovanna Martins Domingos, Grazielle Jesus Dos Santos, Elisângela Düsman, Ana Beatriz Sousa Santana, Patricia Aline Bressiani, Ágatha Giovanna Fragoso, Angélica Priscila Parussolo Tonin, Eduardo César Meurer","doi":"10.1002/cbdv.71827","DOIUrl":"10.1002/cbdv.71827","url":null,"abstract":"The brewing industry generates large amounts of waste containing bioactive compounds with potential applications in the pharmaceutical and cosmetic industries. This study optimized the extraction of bioactive compounds from hot trub using 70:30 (v/v) ethanol:water as the extraction solvent, with time and temperature optimized through an experimental design. The optimized extract exhibited high antioxidant activity and was rich in phenolic acids, flavonoids, and xanthohumol. The extract demonstrated promising photoprotective properties, with a sun protection factor of 13.84, suggesting its potential for dermocosmetic use. The extract was encapsulated in zein nanoparticles, including chitosan-coated and sodium caseinate-coated variants, to enhance stability, bioavailability, and bioactivity. The effect of the encapsulated extract on cell viability was evaluated against the MCF-7 breast cancer cell line. Results indicated that encapsulation in zein nanoparticles improved the in vitro effect of the extract on MCF-7 cell viability, with chitosan and sodium caseinate coatings enhancing this effect. These findings highlight hot trub as a sustainable source of bioactive compounds with potential for dermocosmetic applications and as a basis for further investigation in cancer research. Future studies should focus on evaluating the long-term stability of the nanoparticles and on assessing their biological activity in more complex models.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71827"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxicity and α-Amylase Inhibitory Activities of Limonoids From the Leaves of Azadirachta indica. 印楝叶柠檬素的细胞毒性及α-淀粉酶抑制活性。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71835

Ying Yang, Yu-Xin Yan, Ming-Hua Qiu

引用次数: 0

Design and Synthesis of Novel Biginelli Adducts: Anticancer Activity and In Silico Study. 新型Biginelli加合物的设计和合成：抗癌活性和硅研究。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71810

Aida Iraji, Sara Moghadam Farid, Mohammadreza Eftekharian, Paniz Naseri, Mohammad Mahdavi, Mina Saeedi, Tahmineh Akbarzadeh

引用次数: 0

Biological Activities and Phytochemical Composition of Arum rupicola var. rupicola: An In Vitro and In Silico Study. 红豆海芋的生物活性和植物化学成分：体外和硅片研究。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71785

Selim Can Kamalak, Ela Nur Şimşek Sezer, Erdoğan Güneş

{"title":"Biological Activities and Phytochemical Composition of Arum rupicola var. rupicola: An In Vitro and In Silico Study.","authors":"Selim Can Kamalak, Ela Nur Şimşek Sezer, Erdoğan Güneş","doi":"10.1002/cbdv.71785","DOIUrl":"10.1002/cbdv.71785","url":null,"abstract":"The phytochemical composition and biological activities of extracts obtained from the aerial parts (ARA), fruits (ARF), and rhizomes (ARR) of Arum rupicola var. rupicola (Araceae) were investigated using in vitro and in silico approaches. Phenolic and volatile profiles were characterized by HPLC and GC/MS. Antioxidant (DPPH), antimicrobial (MIC), and cytotoxic (MTT) activities were evaluated. Molecular docking, MM-GBSA, and ADME analyses were performed using Schrödinger Maestro. HPLC revealed that rutin (35,001 µg/mL) and coumaric acid (13,145 µg/mL) were the dominant phenolics in ARA, while quercetin (18,256 µg/mL) predominated in ARF. ARA showed the strongest cytotoxic activity against HL-60 cells with an IC50 value of 141 µg/mL and a selectivity index of 3.8. The strongest antimicrobial activity was observed in ARR against Bacillus cereus (MIC: 90 µg/mL). Molecular docking indicated that rutin exhibited high binding affinity toward cancer-related and antimicrobial targets, with docking scores of -9.24 and -9.32 kcal/mol against KRAS G12D and β-lactamase, respectively. ADME analysis showed that most compounds complied with Lipinski's Rule of Five. These findings highlight the potential of A. rupicola var. rupicola as a source of anticancer and antimicrobial agents.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71785"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Biotransformation of Low-Rank Coal Into Chemical Feedstocks by Indigenous Fungi and Chemical Pretreatment. 乡土真菌与化学预处理协同转化低阶煤为化工原料。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71826

Samia Anjum, Muhammad Adnan Sabar, Javed Khan, Aneela Younas Malik, Asif Jamal, Zaixing Huang, Ahsan Habib, Muhammad Ishtiaq Ali, Yusuf Tutar

{"title":"Synergistic Biotransformation of Low-Rank Coal Into Chemical Feedstocks by Indigenous Fungi and Chemical Pretreatment.","authors":"Samia Anjum, Muhammad Adnan Sabar, Javed Khan, Aneela Younas Malik, Asif Jamal, Zaixing Huang, Ahsan Habib, Muhammad Ishtiaq Ali, Yusuf Tutar","doi":"10.1002/cbdv.71826","DOIUrl":"10.1002/cbdv.71826","url":null,"abstract":"Fungal biotransformation of subbituminous coal into chemical feedstocks provides an eco-friendly and cost-effective approach for sustainable coal utilization. In this study, the fungal isolates AD-3 (Neurospora crassa) and AD-5 (Penicillium simplicissimum) from a Pakistani subbituminous coal, optimization, and enhancing agents play a valuable role in the enhanced biodegradation processes. Optimal conditions yielded substantial organic release with 1% and 1.5% (w/v) glucose, 0.5% pulverized coal within 7 and 17 days of incubation. NaOH and sodium acetate enhanced fungal coal degradation by modifying coal structure and promoting organic compound release. The GC-MS analysis of the solubilized black liquid showed a more diverse variety of organic compounds in chemically treated coal than the virgin coal. The analyses showed 31.29% ± 0.23% (AD-3) and 44.9% ± 0.26% (AD-5) solubilization of virgin coal, increasing to 50.9% ± 0.23% (AD-3) and 68.4% ± 0.30% (AD-5) after chemical pretreatment. The solubilized fraction and residual coal were analyzed with FTIR to explore the functional group aroused by the conjugative effect of the chemical and fungal attacks. This analysis showed that the combination of chemical treatment and biotransformation by indigenous fungi from coal environments has the potential to exploit the low-rank coal for chemical feedstock production.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71826"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated Biological Evaluation of Benzimidazolium-Chalcone Derivatives: Antioxidant, Anti-AChE, Anticancer, and Anti-MRSA Activities With Docking Insights. 苯并咪唑-查尔酮衍生物的综合生物学评价：抗氧化、抗乙酰胆碱酯酶、抗癌和抗mrsa活性与对接见解。

IF 2.9 3区化学

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI: 10.1002/cbdv.71828

Mehmet Çimentepe, Hakan Ünver, Adem Necip, Mehmet Ersatir, Burcu Demirbağ, Özge Öztürk Çimentepe, Metin Yildirim

{"title":"Integrated Biological Evaluation of Benzimidazolium-Chalcone Derivatives: Antioxidant, Anti-AChE, Anticancer, and Anti-MRSA Activities With Docking Insights.","authors":"Mehmet Çimentepe, Hakan Ünver, Adem Necip, Mehmet Ersatir, Burcu Demirbağ, Özge Öztürk Çimentepe, Metin Yildirim","doi":"10.1002/cbdv.71828","DOIUrl":"10.1002/cbdv.71828","url":null,"abstract":"Four new benzimidazolium-chalcone salt derivatives were synthesized and successfully characterized using 1H NMR, 13C NMR, and FT-IR spectroscopy. Their antioxidant activity, acetylcholinesterase (AChE) inhibitory potential, antibacterial and antibiofilm activities against MRSA and MSSA strains, as well as their anticancer and apoptosis-inducing properties in human colon adenocarcinoma (HT-29) cells, were comprehensively evaluated. Among the synthesized compounds, 3a exhibited the strongest antioxidant activity, with IC50 values of 10.13 ± 0.30 µg/mL in the ABTS assay and 79.40 µg/mL in the DPPH assay, and demonstrated the highest AChE inhibitory effect. Molecular docking analysis further supported these findings, revealing a favorable binding affinity of compound 3a toward the 4EY7 target protein, with a docking score of -8.619 kcal/mol. Antibacterial evaluation using the agar well diffusion method showed that compound 3b produced the largest inhibition zone (19.2 ± 0.6 mm). Consistently, MIC analysis confirmed that 3b displayed potent antibacterial activity against MRSA (MIC: 1 µg/mL) and exhibited the most pronounced antibiofilm effect among the tested derivatives. In cytotoxicity assays, compound 3c demonstrated the highest anticancer activity against HT-29 cells, with an IC50 value of 16.7 ± 2.09 µM. Apoptosis analysis revealed that 3c predominantly induced early-stage apoptosis.","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":"e71828"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0