深海真菌曲霉sp.三种新的苯醚衍生物。SCSIO 41230。

IF 2.5 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-09-30 DOI:10.1002/cbdv.202502248

Yanchun He, Shuna Xu, Juan Gao, Juan Liu, Xuefeng Zhou, Yonghong Liu, Xiaoyong Zhang, Bin Yang

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引用次数: 0

摘要

从深海源真菌Aspergillus sp. SCSIO 41230中分离得到3个新的苯醚衍生物（1-3）和11个已知化合物（4-14）。通过核磁共振（NMR）分析、高分辨率电喷雾质谱分析和核磁共振计算对新化合物的结构进行了鉴定。生物实验表明，化合物6对PC-3和22Rv1细胞具有较弱的细胞毒活性，化合物4对耐甲氧西林金黄色葡萄球菌具有较强的抑菌活性，最低抑菌浓度为4.13µg/mL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Three New Phenyl Ether Derivatives From the Deep-Sea-Derived Fungus Aspergillus sp. SCSIO 41230.

Three new phenyl ether derivatives (1-3) and 11 known compounds (4-14) were isolated from the deep-sea-derived fungus Aspergillus sp. SCSIO 41230. The structures of the new compounds were elucidated by analysis of the nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry, and NMR calculations. The bioassays indicated that compound 6 showed weak cytotoxic activity against PC-3 and 22Rv1 cells, and compound 4 exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration value of 4.13 µg/mL.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.