桃荚苋和蓝荚苋抗糖尿病和抗氧化性能的比较研究:酚类化合物的LC-MS/MS谱分析。

IF 2.5 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zahra Effatparvar, Bilge Aydın, Hafize Yuca, Mehmet Önal, Gökhan Zengin, Ayşe Çiçek Kaya, Songül Karakaya, Agnese Santanatoglia, Ahmed Mustafa, Giovanni Caprioli, Zühal Güvenalp
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引用次数: 0

摘要

本研究旨在评价柞蚕豆和柞蚕豆部位甲醇提取物的抗糖尿病和抗氧化性能,并采用LC-MS/MS分析方法鉴定其生物活性成分。LC-MS/MS分析结果显示,花楸叶片的总多酚含量最高(78.955µg/g干提取物),其次是白杨枝条(67.203µg/g干提取物),绿原酸是两种植物的主要化合物。通过抑制α-淀粉酶和α-葡萄糖苷酶来评估抗糖尿病潜力,通过ABTS和DPPH自由基清除试验来评估抗氧化活性。在α-葡萄糖苷酶抑制实验中,两种植物叶片、细枝和果实的甲醇提取物的α-葡萄糖苷酶抑制活性均高于阳性对照阿卡波糖,其中花楸叶片提取物的抑制作用最强。在抗氧化能力方面,花叶提取物表现出最高的抗氧化能力,优于α-生育酚和Trolox。值得注意的是,在ABTS自由基清除实验中,与α-生育酚和Trolox相比,花楸叶提取物具有更强的抑制作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Study of Antidiabetic and Antioxidant Properties of Viburnum opulus L. and Viburnum lantana L. (Viburnaceae): LC-MS/MS Profiling of Phenolic Compounds.

This study aimed to evaluate antidiabetic and antioxidant properties of Viburnum opulus and Viburnum lantana aerial parts methanolic extracts, alongside identification of their bioactive constituents using LC-MS/MS analysis. LC-MS/MS analysis revealed that V. lantana leaves had the highest total polyphenol content (78.955 µg/g dry extract), followed by V. opulus twigs (67.203 µg/g dry extract), with chlorogenic acid being the predominant compound in both species. Antidiabetic potential was assessed through inhibition of α-amylase and α-glucosidase enzymes, while antioxidant activity was determined via ABTS and DPPH radical scavenging assays. In the α-glucosidase inhibition assay, methanolic extracts from leaves, fine branches, and fruits of both species exhibited greater inhibitory activity than the positive control, acarbose, with the leaf extract of V. lantana displaying the strongest inhibition. Regarding antioxidant capacity, V. lantana leaf extracts demonstrated the highest efficacy, outperforming α-tocopherol and Trolox. Notably, in the ABTS radical scavenging assay, V. lantana leaf extracts exhibited superior inhibitory effects compared to α-tocopherol and Trolox.

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来源期刊
Chemistry & Biodiversity
Chemistry & Biodiversity 环境科学-化学综合
CiteScore
3.40
自引率
10.30%
发文量
475
审稿时长
2.6 months
期刊介绍: Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.
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